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https://www.readbyqxmd.com/read/28231628/the-lived-experience-of-recovery-during-the-first-six-months-after-colorectal-cancer-surgery
#1
Jenny Jakobsson, Ewa Idvall, Christine Kumlien
AIMS AND OBJECTIVES: The objective of this study was to describe the lived experience of recovery during the first six months after colorectal cancer surgery. BACKGROUND: Colorectal cancer is the third most common cancer-diagnose worldwide. Early discharge places demands on health care professionals to prepare patients for their return home and to provide them with appropriate support throughout the recovery process. This requires knowledge of what it is like to recover from colorectal cancer surgery...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28231624/targets-and-mechanisms-in-prevention-of-parkinson-s-disease-through-immunomodulatory-treatments
#2
REVIEW
Marianne von Euler Chelpin, Thomas Vorup-Jensen
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the world, however, there is no cure for it. Current treatments only relieve some of the symptoms, without ceasing the disease, and lose efficacy with prolonged treatment. Considerable evidence shows that persistent inflammatory responses, involving T cell infiltration and glial cell activation, are common characteristics of human patients and play a crucial role in the degeneration of dopaminergic neurons. Therefore, it is important to develop therapeutic strategies that can impede or halt the disease through the modulation of the peripheral immune system by aiming at controlling the existing neuroinflammation...
February 23, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28231422/adiponitrile-litfsi-solution-as-alkylcarbonate-free-electrolyte-for-lto-nmc-li-ion-batteries
#3
Douaa Farhat, Fouad Ghamouss, Julia Maibach, Kristina Edström, Daniel Lemordant
Recently, dinitriles (NC(CH2)nCN) and especially adiponitrile (ADN, n=4) have attracted the attention as secure electrolyte solvents due to their chemical stability, high boiling points, high flash points and low vapor pressure. The good solvating properties of ADN toward lithium salts and its high electrochemical stability (~ 6V vs. Li/Li+) make it suitable for safer Li-ions cells without performances loss. In this study, ADN is used as a single electrolyte solvent with lithium bis(trimethylsulfonyl)imide (LiTFSI)...
February 23, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28231406/fungal-adaptation-to-contemporary-fungicide-applications-the-case-of-botrytis-cinerea-populations-from-champagne-vineyards-france
#4
A-S Walker, V Ravigne, A Rieux, S Ali, F Carpentier, E Fournier
In addition to being one of the most acute problems impeding chemical control of fungal diseases, the evolution of fungicide resistance is an emblematic case of local adaptation to spatially heterogeneous and temporally variable selection pressures. Here we dissected the adaptation of Botrytis cinerea (the causal agent of grey mould) populations on grapes to several fungicides. We carried out a two-year survey (four collection dates) on three treated/untreated pairs of plots from vineyards in Champagne (France), and monitored the frequency of four resistant phenotypes that are unambiguously associated to four distinct genotypes...
February 23, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28231273/periovulatory-follicular-fluid-levels-of-estradiol-trigger-inflammatory-and-dna-damage-responses-in-oviduct-epithelial-cells
#5
Sergio E Palma-Vera, Jennifer Schoen, Shuai Chen
OBJECTIVE: Ovarian steroid hormones (mainly E2 and P4) regulate oviduct physiology. Serum-E2 acts on the oviduct epithelium from the basolateral cell compartment. Upon ovulation, the apical compartment of the oviduct epithelium is temporarily exposed to follicular fluid, which contains much higher levels of E2 than serum. The aim of this study was to evaluate the effects of human periovulatory follicular fluid levels of E2 on oviduct epithelial cells using two porcine in vitro models...
2017: PloS One
https://www.readbyqxmd.com/read/28231270/correction-htlv-1-bzip-factor-enhances-t-cell-proliferation-by-impeding-the-suppressive-signaling-of-co-inhibitory-receptors
#6
Haruka Kinosada, Jun-Ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka
[This corrects the article DOI: 10.1371/journal.ppat.1006120.].
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28231031/different-serological-profiles-to-cooccurring-pathogenic-and-nonpathogenic-caliciviruses-in-wild-european-rabbits-oryctolagus-cuniculus-across-australia
#7
Tanya E Cox, June Liu, Remy van de Ven, Tanja Strive
Rabbit hemorrhagic disease virus (RHDV) was released in Australia as a biocontrol agent for wild European rabbits ( Oryctolagus cuniculus ) in 1995-96; however, its effects were variable across Australia with the greatest population reductions seen in lower annual rainfall areas (<400 mm). There is speculation that the reduced effectiveness observed at higher annual rainfall sites is at least partially due to the presence of a nonpathogenic calicivirus (RCV-A1). The RCV-A1 is related to RHDV and confers partial and transient protection against lethal RHDV infection in laboratory tests...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28230991/electron-accumulation-on-naphthalene-diimide-photosensitized-by-ru-2-2-bipyridine-3-2
#8
Michael Skaisgirski, Xingwei Guo, Oliver S Wenger
In a molecular triad comprised of a central naphthalene diimide (NDI) unit flanked by two [Ru(bpy)3](2+) (bpy = 2,2'-bipyridine) sensitizers, NDI(2-) is formed after irradiation with visible light in deaerated CH3CN in the presence of excess triethylamine. The mechanism for this electron accumulation involves a combination of photoinduced and thermal elementary steps. In a structurally related molecular pentad with two peripheral triarylamine (TAA) electron donors attached covalently to a central [Ru(bpy)3](2+)-NDI-[Ru(bpy)3](2+) core but no sacrificial reagents present, photoexcitation only leads to NDI(-) (and TAA(+)), whereas NDI(2-) is unattainable due to rapid electron transfer events counteracting charge accumulation...
February 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28230846/best-practices-in-data-analysis-and-sharing-in-neuroimaging-using-mri
#9
Thomas E Nichols, Samir Das, Simon B Eickhoff, Alan C Evans, Tristan Glatard, Michael Hanke, Nikolaus Kriegeskorte, Michael P Milham, Russell A Poldrack, Jean-Baptiste Poline, Erika Proal, Bertrand Thirion, David C Van Essen, Tonya White, B T Thomas Yeo
Given concerns about the reproducibility of scientific findings, neuroimaging must define best practices for data analysis, results reporting, and algorithm and data sharing to promote transparency, reliability and collaboration. We describe insights from developing a set of recommendations on behalf of the Organization for Human Brain Mapping and identify barriers that impede these practices, including how the discipline must change to fully exploit the potential of the world's neuroimaging data.
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28230794/structural-determinant-and-its-underlying-molecular-mechanism-of-stpc2-related-to-anti-angiogenic-activity
#10
Min Hu, Ning Cui, Zhixiang Bo, Feixiang Xiang
In this study, we aimed to use different strategies to further uncover the anti-angiogenic molecular mechanism of a fucoidan-like polysaccharide STPC2, isolated from brown alga Sargassum thunbergii. A desulfated derivative, STPC2-DeS, was successfully prepared and identified. The native polysaccharide and desulfated product were subjected to evaluate their anti-angiogenic effects. In the tube formation assay, STPC2 showed dose-dependent inhibition. In addition, STPC2 could distinctly inhibit the permeation of HUVEC cells into the lower chamber...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28230635/valproic-acid-modulates-platelet-and-coagulation-function-ex-vivo
#11
Ted Bambakidis, Simone E Dekker, Ihab Halaweish, Baoling Liu, Vahagn C Nikolian, Patrick E Georgoff, Patryk Piascik, Yongqing Li, Martin Sillesen, Hasan B Alam
Trauma-induced coagulopathy is associated with adverse patient outcome. Animal models demonstrate that histone deacetylase inhibitors, such as valproic acid (VPA), improve survival following injury. While in-vivo data suggest that improved survival may in part be because of an attenuation of coagulopathy, it remains unknown whether this is a direct effect of the drug, or the establishment of an overall prosurvival phenotype. We thus conducted an ex-vivo experiment to determine if VPA has an effect on coagulation and platelet function...
February 21, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28230616/validating-the-postdischarge-surgical-recovery-scale-13-as-a-measure-of-perceived-postoperative-recovery-after-laparoscopic-sacrocolpopexy
#12
Janet S Carpenter, Michael Heit, Chen X Chen, Ryan Stewart, Jennifer Hamner, Kevin L Rand
OBJECTIVES: No postoperative recovery measurement tools have been validated among women undergoing laparoscopic sacrocolpopexy for pelvic organ prolapse, which impedes development and testing of strategies to improve recovery. The purpose of this study was to evaluate the performance of the Postdischarge Surgical Recovery Scale (PSR) as a measure of perceived recovery in laparoscopic sacrocolpopexy patients. METHODS: Women (N = 120) with stage 2 or higher pelvic organ prolapse undergoing laparoscopic sacrocolpopexy completed a 15-minute postoperative survey (days 7, 14, 42, and 90 [each ± 3 days]) which included the 15-item PSR...
March 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28230080/demonstrating-the-potential-of-yttrium-doped-barium-zirconate-electrolyte-for-high-performance-fuel-cells
#13
Kiho Bae, Dong Young Jang, Hyung Jong Choi, Donghwan Kim, Jongsup Hong, Byung-Kook Kim, Jong-Ho Lee, Ji-Won Son, Joon Hyung Shim
In reducing the high operating temperatures (≥800 °C) of solid-oxide fuel cells, use of protonic ceramics as an alternative electrolyte material is attractive due to their high conductivity and low activation energy in a low-temperature regime (≤600 °C). Among many protonic ceramics, yttrium-doped barium zirconate has attracted attention due to its excellent chemical stability, which is the main issue in protonic-ceramic fuel cells. However, poor sinterability of yttrium-doped barium zirconate discourages its fabrication as a thin-film electrolyte and integration on porous anode supports, both of which are essential to achieve high performance...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229957/origins-and-mechanisms-of-hysteresis-in-organometal-halide-perovskites
#14
Cheng Li, Antonio Guerrero, Yu Zhong, Sven Huettner
Inorganic-organic organometal halide perovskites, such as CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> or CsPbI<sub>3</sub>, etc., are an unprecedented rising star in the field of photovoltaics since 2009, owing to its exceptionally high power conversion efficiency (PCE) and simple fabrication processability. Despite its relatively short history of development, intensive investigations have been concentrating on this material, ranging from crystal structure analysis and photophysical characterization, to performance optimization and device integration, etc...
February 23, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28229432/spontaneous-torsion-of-the-right-upper-lung-lobe-a-case-report
#15
Yusuke Kita, Tetsuhiko Go, Kazuhito Nii, Natsumi Matsuura, Hiroyasu Yokomise
BACKGROUND: Pulmonary torsion is usually caused by thoracic surgery or trauma. Spontaneous pulmonary torsion caused by tumor and pleural effusion is very rare. CASE PRESENTATION: A 76-year-old Asian male with a chronic cough and suspected lung or pleural tumor presented with sudden dyspnea. Computed tomography showed that the right upper lung lobe contained a large tumor in the region of S1-3; the tumor had shifted to the posterior thoracic space and rotated 90° counterclockwise, potentially impeding blood flow...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28229330/the-involvement-of-the-myelin-associated-inhibitors-and-their-receptors-in-cns-plasticity-and-injury
#16
REVIEW
Anthony G Boghdadi, Leon Teo, James A Bourne
The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair...
February 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28229244/prevalence-and-correlates-of-use-of-safer-conception-methods-in-a-prospective-cohort-of-ugandan-hiv-affected-couples-with-fertility-intentions
#17
Glenn J Wagner, Sebastian Linnemayr, Kathy Goggin, Deborah Mindry, Jolly Beyeza-Kashesya, Sarah Finocchario-Kessler, Eric Robinson, Josephine Birungi, Rhoda K Wanyenze
We examined the prevalence and correlates of safer conception methods (SCM) use in HIV-affected couples with fertility intentions. A prospective cohort of 400 HIV clients in Uganda who had fertility intentions with their partner was surveyed every 6 months for 24 months. Logistic regression analysis was used to determine individual, relationship and provider level predictors of SCM use. Over one-third (35%) reported any use of timed unprotected intercourse (TUI) during the study; use of other SCM was rare...
February 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28228623/elucidation-of-mechanism-of-blood-brain-barrier-damage-for-prevention-and-treatment-of-vascular-dementia
#18
Masaki Ueno
It is well-known that the blood-brain barrier (BBB) plays significant roles in transporting intravascular substances into the brain. The BBB in cerebral capillaries essentially impedes the influx of intravascular compounds from the blood to the brain, while nutritive substances, such as glucose, can be selectively transported through several types of influx transporters in endothelial cells. In the choroid plexus, intravascular substances can invade the parenchyma as fenestrations exist in endothelial cells of capillaries...
February 22, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28228510/non-glandular-trichomes-of-solanum-carolinense-deter-feeding-by-manduca-sexta-caterpillars-and-cause-damage-to-the-gut-peritrophic-matrix
#19
Rupesh R Kariyat, Jason D Smith, Andrew G Stephenson, Consuelo M De Moraes, Mark C Mescher
Plant trichomes constitute a first line of defence against insect herbivores. The pre- and post-ingestive defensive functions of glandular trichomes are well documented and include direct toxicity, adhesion, antinutrition and defence gene induction. By contrast, the defensive functions of non-glandular trichomes are less well characterized, although these structures are thought to serve as physical barriers that impede herbivore feeding and movement. We experimentally varied the density of stellate non-glandular trichomes in several ways to explore their pre- and post-ingestive effects on herbivores...
February 22, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28228254/control-of-mitochondrial-remodeling-by-the-atpase-inhibitory-factor-1%C3%A2-unveils-a-pro-survival-relay-via-opa1
#20
Danilo Faccenda, Junji Nakamura, Giulia Gorini, Gurtej K Dhoot, Mauro Piacentini, Masusuke Yoshida, Michelangelo Campanella
The ubiquitously expressed ATPase inhibitory factor 1 (IF1) is a mitochondrial protein that blocks the reversal of the F1Fo-ATPsynthase, preventing dissipation of cellular ATP and ischemic damage. IF1 suppresses programmed cell death, enhancing tumor invasion and chemoresistance, and is expressed in various types of human cancers. In this study, we examined its effect on mitochondrial redox balance and apoptotic cristae remodeling, finding that, by maintaining ATP levels, IF1 reduces glutathione (GSH) consumption and inactivation of peroxiredoxin 3 (Prx3) during apoptosis...
February 21, 2017: Cell Reports
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