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https://www.readbyqxmd.com/read/28550489/impedance-ph-monitoring-for-diagnosis-of-reflux-disease-new-perspectives
#1
REVIEW
Marzio Frazzoni, Nicola de Bortoli, Leonardo Frazzoni, Salvatore Tolone, Vincenzo Savarino, Edoardo Savarino
Heartburn is the most specific symptom of gastroesophageal reflux disease (GERD). In clinical practice, heartburn relief by a proton pump inhibitor (PPI) trial does suffice to confirm GERD. However, an objective diagnosis of GERD is required before anti-reflux endoscopic or surgical interventions, independently from PPI response. Thus, since normal findings at upper endoscopy are detected in the majority of patients with heartburn, reflux monitoring is often required. When traditional catheter-based or wireless pH tests are used, reflux episodes are conventionally identified by pH drops below 4...
May 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28550439/baseline-anthropometric-and-metabolic-parameters-correlate-with-weight-loss-in-women-1-year-after-laparoscopic-roux-en-y-gastric-bypass
#2
Sans Arnaud, Bailly Laurent, Anty Rodolphe, Sielezenef Igor, Gugenheim Jean, Tran Albert, Gual Philippe, Iannelli Antonio
BACKGROUND: In this study, we explored in a prospective cohort of morbidly obese women undergoing laparoscopic Roux-en-Y gastric bypass (LRYGP) correlations between baseline anthropometrics, metabolic parameters, resting energy expenditure (REE), body composition, and 1-year % excess body mass index loss (%EBMIL). We also investigated risk factors for insufficient %EBMIL. METHODS: One hundred three consecutive women were prospectively evaluated at baseline (age 40...
May 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28550425/cpg-oligonucleotide-mediated-co-stimulation-of-mouse-invariant-natural-killer-t-cells-negatively-regulates-their-activation-status
#3
Raveendra R Kulkarni, Alexander Ian Villanueva, Leah R Read, Jennifer T Brisbin, Siddhartha Kumar Bhaumik, Jonathan LaMarre, Kaja Murali-Krishna, Shayan Sharif
Invariant natural killer T (iNKT) cells play important roles in antimicrobial defense and immune-regulation. We have previously shown that iNKT cells express certain toll-like receptors (TLR), and that TLR co-stimulation of iNKT cells in the presence of suboptimal concentrations of T cell receptor (TCR) agonists enhances cellular activation. In the present study, we investigated the regulatory effects of CpG oligonucleotides in mouse primary hepatic and splenic iNKT cells and in DN32.D3 iNKT cells. We show that CpG treatment of iNKT cells in the presence of higher concentrations of TCR agonists (α-GalCer or anti-CD3 mAb) results in the up-regulation of TLR9 in iNKT cells with a concurrent reduction in their cellular activation, as assessed by their production of IL-2, IL-4 and IFN-γ compared with controls...
May 27, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28550300/experimental-quantum-chemical-and-molecular-dynamic-simulations-studies-on-the-corrosion-inhibition-of-mild-steel-by-some-carbazole-derivatives
#4
Henry U Nwankwo, Lukman O Olasunkanmi, Eno E Ebenso
Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The carbazole derivatives were found to be mixed type inhibitors with predominantly cathodic inhibitive effects for mild steel in 1 M HCl...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550154/an-amperometric-h2o2biosensor-based-on-hemoglobin-nanoparticles-immobilized-onto-a-gold-electrode
#5
Vinay Narwal, Neelam Yadav, Manisha Thakur, Chandra Shekhar Pundir
The nanoparticles (NPs) of hemoglobin (Hb) were prepared by desolvation method and characterized by transmission electron microscopy (TEM), ultraviolet (UV) spectroscopy and Fourier-transform infrared spectroscopy (FTIR). An amperometric H2O2 biosensor was constructed by immobilizing HbNPs covalently onto a polycrystalline Au electrode (AuE). HbNPs/AuE was characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) before and after immobilization of HbNPs...
May 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28549455/inter-act-prevention-of-pregnancy-complications-through-an-e-health-driven-interpregnancy-lifestyle-intervention-study-protocol-of-a-multicentre-randomised-controlled-trial
#6
Annick Bogaerts, Lieveke Ameye, Margriet Bijlholt, Kelly Amuli, Dorine Heynickx, Roland Devlieger
BACKGROUND: Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy. METHODS: INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Eligible women are recruited for the study at day 2 or 3 postpartum...
May 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28549374/metabolic-engineering-of-escherichia-coli-to-high-efficient-synthesis-phenylacetic-acid-from-phenylalanine
#7
Lihua Zhang, Qian Liu, Hong Pan, Xun Li, Daoyi Guo
Phenylacetic acid (PAA) is a fine chemical with a high industrial demand for its widespread uses. Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28549353/crowding-visual-awareness-and-their-respective-neural-loci
#8
Kilho Shin, Susana T L Chung, Bosco S Tjan
In peripheral vision, object identification can be impeded when a target object is flanked by other objects. This phenomenon of crowding has been attributed to basic processes associated with image encoding by the visual system, but the neural origin of crowding is not known. Determining whether crowding depends on subjective awareness of the flankers can provide information on the neural origin of crowding. However, recent studies that manipulated flanker awareness have yielded conflicting results. In the current study, we suppressed flanker awareness with two methods: interocular suppression (IOS) and adaptation-induced blindness (AIB)...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28548972/assessment-of-adult-malnutrition-and-prognosis-with-bioelectrical-impedance-analysis-phase-angle-and-impedance-ratio
#9
Henry C Lukaski, Ursula G Kyle, Jens Kondrup
PURPOSE OF REVIEW: Malnutrition affects prognosis in many groups of patients. Although screening tools are available to identify adults at risk for poor nutritional status, a need exists to improve the assessment of malnutrition by identifying the loss of functional tissues that can lead to frailty, compromised physical function, and increased risk of morbidity and mortality, particularly among hospitalized and ill patients and older adults. Bioimpedance analysis (BIA) offers a practical approach to identify malnutrition and prognosis by assessing whole-body cell membrane quality and depicting fluid distribution for an individual...
May 25, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28548823/atmosphere-and-voltage-dependent-electronic-conductivity-of-oxide-ion-conducting-zr1-xyxo2-x-2-ceramics
#10
Marc Jovaní, Héctor Beltrán-Mir, Eloisa Cordoncillo, Anthony R West
Cubic, fluorite-structured solid solutions Zr1-xYxO2-x/2 (YSZ; x = 0.4-0.7) were prepared by sol-gel synthesis. Impedance measurements on pellets of 85% approximate density sintered at 1300 °C for 24 h showed strong evidence of oxide ion conduction with an inclined Warburg spike at low frequencies and capacitance values of ∼10(-6) F cm(-1) at 40 Hz. Arrhenius plots of total pellet conductivities were linear with activation energies of 1.4-1.56 eV. The conductivity decreased with x and was 2-4 orders of magnitude lower than that with optimized YSZ, x = 0...
May 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28548480/d-retro-enantiomer-of-quorum-sensing-peptides-modified-polymeric-micelles-for-brain-tumor-targeted-drug-delivery
#11
Danni Ran, Jiani Mao, Changyou Zhan, Cao Xie, Huitong Ruan, Man Ying, Jianfen Zhou, Wan-Liang Lu, Weiyue Lu
In comparison to other tumors, various barriers such as the blood-brain barrier (BBB), enzymatic barriers and the blood-brain tumor barrier (BBTB) severely impede the successful treatment of glioma. Peptide ligands were frequently used as targeting moieties to mediate brain tumor targeted drug delivery. LWSW (SYPGWSW) is a recently reported quorum sensing peptide which is able to efficiently cross the BBB. Even though the linear LWSW traverses the BBB in vitro, its' in vivo targeting ability has been greatly impaired due to proteolysis...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28547861/effects-of-organic-and-inorganic-nitrate-on-aortic-and-carotid-haemodynamics-in-heart-failure-with-preserved-ejection-fraction
#12
Julio A Chirinos, Francisco Londono-Hoyos, Payman Zamani, Melissa Beraun, Philip Haines, Izzah Vasim, Swapna Varakantam, Timothy S Phan, Thomas P Cappola, Kenneth B Margulies, Raymond R Townsend, Patrick Segers
AIMS: To assess the haemodynamic effects of organic vs. inorganic nitrate administration among patients with heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We assessed carotid and aortic pressure-flow relations non-invasively before and after the administration of 0.4 mg of sublingual nitroglycerin (n = 26), and in a separate sub-study, in response to 12.9 mmoL of inorganic nitrate (n = 16). Nitroglycerin did not consistently reduce wave reflections arriving at the proximal aorta (change in real part of reflection coefficient, 1st harmonic: -0...
May 25, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28546825/efficient-isolation-of-magnolia-protoplasts-and-the-application-to-subcellular-localization-of-mdehsf1
#13
Yamei Shen, Dong Meng, Kim McGrouther, Junhong Zhang, Lailiang Cheng
BACKGROUND: Magnolia is a woody ornamental plant, which is widely used in urban landscaping. However, its lengthy juvenile period and recalcitrance to regeneration impedes functional characterization of its genes. RESULTS: We developed an efficient protoplast isolation and transient expression system for Magnolia denudata × Magnolia acuminata 'Yellow River'. The highest yield of protoplasts was obtained from young leaves digested in 3% Cellulase R10, 0.8% Macerozyme R10, 0...
2017: Plant Methods
https://www.readbyqxmd.com/read/28546376/noninvasive-monitoring-of-oxygen-and-ventilation
#14
Craig D Smallwood, Brian K Walsh
Noninvasive monitoring of oxygenation and ventilation is an essential part of pediatric respiratory care. Carbon dioxide, gas exchange monitoring, transcutaneous monitoring, near-infrared spectroscopy, pulse oximetry, and electrical impedance tomography are examined. Although some of these technologies have been utilized for decades, incorporation into mechanical ventilators and recently developed methods may provide important clinical insights in a broader patient range. Less mature technologies (electrical impedance tomography and near-infrared spectroscopy) have been of particular interest, since they offer easy bedside application and potential for improved care of children with respiratory failure and other disorders...
June 2017: Respiratory Care
https://www.readbyqxmd.com/read/28546282/disease-activity-in-eosinophilic-esophagitis-is-associated-with-impaired-esophageal-barrier-integrity
#15
Marijn J Warners, Bram D van Rhijn, Joanne Verheij, Andreas J P M Smout, Albert J Bredenoord
BACKGROUND: In eosinophilic esophagitis (EoE) the esophageal barrier integrity is impaired. Integrity can be assessed with different techniques. AIMS: To assess the correlations between esophageal eosinophilia and various measures of mucosal integrity, and to evaluate whether endoscopic impedance measurements can predict disease activity. METHODS: Endoscopies and mucosal integrity measurements were performed in adult EoE patients with active disease (≥15 eosinophils/HPF) at baseline (n=32), after fluticasone (n=15) and elemental dietary treatment (n=14) and in controls (n=19)...
May 25, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28546047/an-impedance-based-approach-using-human-ipsc-derived-cardiomyocytes-significantly-improves-in-vitro-prediction-of-in-vivo-cardiotox-liabilities
#16
Bryan Koci, Gregory Luerman, Anika Duenbostell, Ralf Kettenhofen, Heribert Bohlen, Luke Coyle, Brian Knight, Warren Ku, Walter Volberg, Joseph R Woska, Martha P Brown
Current in vitro approaches to cardiac safety testing typically focus on mechanistic ion channel testing to predict in vivo proarrhythmic potential. Outside of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, structural and functional cardiotoxicity related to chronic dosing effects are of great concern as these effects can impact compound attrition. Development and implementation of an in vitro cardiotoxicity screening platform that effectively identifies these liabilities early in the discovery process should reduce costly attrition and decrease preclinical development time...
May 22, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28545875/regional-volume-characteristics-of-the-preterm-infant-receiving-first-intention-continuous-positive-airway-pressure
#17
Risha Bhatia, Peter G Davis, David G Tingay
OBJECTIVE: To determine whether applying nasal continuous positive airway pressure (CPAP) using systematic changes in continuous distending pressure (CDP) results in a quasi-static pressure-volume relationship in very preterm infants receiving first intention CPAP in the first 12-18 hours of life. STUDY DESIGN: Twenty infants at <32 weeks' gestation with mild respiratory distress syndrome (RDS) managed exclusively with nasal CPAP had CDP increased from 5 to 8 to 10 cmH2O, and then decreased to 8 cmH2O and returned to baseline CDP...
May 22, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28545405/genetic-complexity-of-miscanthus-cell-wall-composition-and-biomass-quality-for-biofuels
#18
Tim van der Weijde, Claire L Alvim Kamei, Edouard I Severing, Andres F Torres, Leonardo D Gomez, Oene Dolstra, Chris A Maliepaard, Simon J McQueen-Mason, Richard G F Visser, Luisa M Trindade
BACKGROUND: Miscanthus sinensis is a high yielding perennial grass species with great potential as a bioenergy feedstock. One of the challenges that currently impedes commercial cellulosic biofuel production is the technical difficulty to efficiently convert lignocellulosic biomass into biofuel. The development of feedstocks with better biomass quality will improve conversion efficiency and the sustainability of the value-chain. Progress in the genetic improvement of biomass quality may be substantially expedited by the development of genetic markers associated to quality traits, which can be used in a marker-assisted selection program...
May 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28545172/femoral-nerve-block-versus-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty
#19
REVIEW
In Jun Koh, Young Jun Choi, Man Soo Kim, Hyun Jung Koh, Min Sung Kang, Yong In
Inadequate pain management after total knee arthroplasty (TKA) impedes recovery, increases the risk of postoperative complications, and results in patient dissatisfaction. Although the preemptive use of multimodal measures is currently considered the principle of pain management after TKA, no gold standard pain management protocol has been established. Peripheral nerve blocks have been used as part of a contemporary multimodal approach to pain control after TKA. Femoral nerve block (FNB) has excellent postoperative analgesia and is now a commonly used analgesic modality for TKA pain control...
June 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28544998/chronic-toxicity-of-five-metals-to-the-polar-marine-microalga-cryothecomonas-armigera-application-of-a-new-bioassay
#20
Darren J Koppel, Francesca Gissi, Merrin S Adams, Catherine K King, Dianne F Jolley
The paucity of ecotoxicological data for Antarctic organisms is impeding the development of region-specific water quality guidelines. To address this limitation, toxicity testing protocols need to be developed to account for the unique physiology of polar organisms, in particular their slow growth rates. In this study, a toxicity test protocol was developed to investigate the toxicities of five metals to the polar marine microalga Cryothecomonas armigera. The concentrations which reduced population growth rate by 10% (EC10) after 24-d for Cu, Pb, Zn, Cd and Ni were 21...
May 22, 2017: Environmental Pollution
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