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https://www.readbyqxmd.com/read/29332257/kynurenic-acid-and-its-derivatives-are-able-to-modulate-the-adhesion-and-locomotion-of-brain-endothelial-cells
#1
Eszter Lajkó, Bernadett Tuka, Ferenc Fülöp, István Krizbai, József Toldi, Kálmán Magyar, László Vécsei, László Kőhidai
The neuroprotective actions of kynurenic acid (KYNA) and its derivatives in several neurodegenerative disorders [characterized by damage to the cerebral endothelium and to the blood-brain barrier (BBB)] are well established. Cell-extracellular matrix (ECM) adhesion is supposedly involved in recovery of impaired cerebral endothelium integrity (endothelial repair). The present work aimed to investigate the effects of KYNA and its synthetic derivatives on cellular behaviour (e.g. adhesion and locomotion) and on morphology of the GP8 rat brain endothelial cell line, modeling the BBB endothelium...
January 13, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29331762/suppression-of-capn4-by-microrna-1271-impedes-the-proliferation-and-invasion-of-colorectal-cancer-cells
#2
Jibin Li, Jian Xu, Xiaofei Yan, Keer Jin, Wenya Li, Rui Zhang
Accumulating evidence has suggested that calpain small subunit 1 (Capn4) plays an important role in the development and progression of malignant tumors. However, little is known about the role of Capn4 in colorectal cancer (CRC). In this study, we aimed to investigate the potential role of Capn4 in CRC and the regulation of Capn4 by microRNAs (miRNAs). Here, we found that Capn4 expression was highly up-regulated in CRC cell lines. Knockdown of Capn4 by siRNA significantly inhibited the proliferation and invasion of CRC cell lines...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29331268/the-population-biology-and-transmission-dynamics-of-loa-loa
#3
REVIEW
Charles Whittaker, Martin Walker, Sébastien D S Pion, Cédric B Chesnais, Michel Boussinesq, María-Gloria Basáñez
Endemic to Central Africa, loiasis - or African eye worm (caused by the filarial nematode Loa loa) - affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public health relevance because it impedes mass drug administration-based interventions against onchocerciasis and lymphatic filariasis in co-endemic areas. Recent research has challenged this conception, demonstrating excess mortality associated with high levels of infection, implying that loiasis warrants attention as an intrinsic public health problem...
January 10, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29331094/solvent-impedes-co2-cycloaddition-on-metal-organic-frameworks
#4
Dan Shao, Jinbiao Shi, Jianling Zhang, Xiuniang Tan, Tian Luo, Xiuyan Cheng, Bingxing Zhang, Buxing Han
The catalytic performance of metal-organic frameworks (MOFs) for the synthesis of cyclic carbonate from carbon dioxide and epoxides has been explored in solvent and solvent-free conditions, respectively. It was found that MOF catalysts have significantly improved catalytic activities in solvent-free CO2 cycloaddition reactions than those in solvent. The mechanism was discussed from the competition of solvent with substrate to adhere MOF catalysts during reaction process.
January 13, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29330962/skin-conformal-polymer-electrodes-for-clinical-ecg-and-eeg-recordings
#5
Flurin Stauffer, Moritz Thielen, Christina Sauter, Séverine Chardonnens, Simon Bachmann, Klas Tybrandt, Christian Peters, Christofer Hierold, Janos Vörös
Preparation-free and skin compliant biopotential electrodes with high recording quality enable wearables for future healthcare and the Internet of Humans. Here, super-soft and self-adhesive electrodes are presented for use on dry and hairy skin without skin preparation or attachment pressure. The electrodes show a skin-contact impedance of 50 kΩ cm2 at 10 Hz that is comparable to clinical standard gel electrodes and lower than existing dry electrodes. Microstructured electrodes inspired by grasshopper feet adhere repeatedly to the skin with a force of up to 0...
January 13, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29330571/impact-of-motor-task-execution-on-an-individual-s-ability-to-mirror-forearm-positions
#6
Netta Gurari, Justin M Drogos, Shawn Lopez, Julius P A Dewald
This work is motivated by our goal of determining why individuals with stroke are impaired when locating their arms in space. We assessed the ability of individuals without neurological impairments to mirror their forearms during various motor tasks so that we could identify baseline performance in an unimpaired population. Nine right-hand dominant participants without neurological impairments mirrored forearm positions bi-directionally (i.e., right forearm mirrors left forearm, vice versa) for three motor tasks (i...
January 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29330182/fluorescence-recovery-allows-the-implementation-of-a-fluorescence-reporter-gene-platform-applicable-for-the-detection-and-quantification-of-horizontal-gene-transfer-in-anoxic-environments
#7
Rafael Pinilla, Leise Riber, Søren J Sørensen
The study of horizontal gene transfer (HGT) in microbial communities has been revolutionized by significant advances in cultivation-independent methods based on fluorescence reporter gene technologies. Recently, the combination of these novel approaches with flow cytometry has presented itself as one of the most powerful tools to study the spread of mobile genetic elements (MGEs) in the environment. However, the use of fluorescent markers like green fluorescent protein (GFP) and mCherry is limited by environmental constraints that affect the correct maturation of their fluorophores, such as oxygen availability and pH levels...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29330145/mbd2-ablation-impairs-lymphopoiesis-and-impedes-progression-and-maintenance-of-t-all
#8
Mi Zhou, Kuangguo Zhou, Ling Cheng, Xing Chen, Jue Wang, Xiao-Min Wang, Yingchi Zhang, Qilin Yu, Shu Zhang, Di Wang, Liang Huang, Mei Huang, Ding Ma, Tao Cheng, Cong-Yi Wang, Weiping Yuan, Jianfeng Zhou
Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of the methylated DNA binding protein MBD2 in normal and malignant hematopoiesis. MBD2 ablation led to diminished lymphocytes. Functional defects of the lymphoid compartment were also observed after in vivo reconstitution of MBD2-deficient hematopoietic stem cells (HSC). In an established model of Notch1-driven T cell acute lymphoblastic leukemia (T-ALL), MBD2 ablation impeded malignant progression and maintenance by attenuating the Wnt signaling pathway...
January 12, 2018: Cancer Research
https://www.readbyqxmd.com/read/29329704/a-detailed-electrochemical-impedance-spectroscopy-study-of-a-bismuth-film-glassy-carbon-electrode-for-trace-metal-analysis
#9
Barbara Petovar, Klodian Xhanari, Matjaž Finšgar
A systematic electrochemical impedance spectroscopy (EIS) analysis at different potentials of an in situ-prepared bismuth-film glassy carbon electrode (BiFE) in 0.1 M acetate buffer solution is reported. This electrode is employed in the square-wave anodic stripping voltammetry (SWASV) technique for the determination of trace amounts of the heavy metals Zn, Cd, and Pb. The method was first validated for detection limit, linear range, sensitivity, precision and accuracy to clearly prove the superior action of BiFE compared with the bare glassy carbon electrode (GCE)...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29329555/exercise-during-and-after-neoadjuvant-rectal-cancer-treatment-the-exert-trial-study-protocol-for-a-randomized-controlled-trial
#10
Andria R Morielli, Nawaid Usmani, Normand G Boulé, Diane Severin, Keith Tankel, Tirath Nijjar, Kurian Joseph, Alysa Fairchild, Kerry S Courneya
BACKGROUND: Standard treatment for locally advanced rectal cancer includes 5-6 weeks of neoadjuvant chemoradiotherapy (NACRT) followed by total mesorectal excision 6-8 weeks later. NACRT improves local disease control and surgical outcomes but also causes side effects including fatigue, diarrhea, hand-foot syndrome, and physical deconditioning that may impede quality of life (QoL), treatment completion, treatment response, and long-term prognosis. Interventions to improve treatment outcomes and manage side effects that are safe, tolerable and low-cost are highly desirable...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29329018/corrosion-effect-of-bacillus-cereus-on-x80-pipeline-steel-in-a-beijing-soil-environment
#11
Hongxia Wan, Dongdong Song, Dawei Zhang, Cuiwei Du, Dake Xu, Zhiyong Liu, De Ding, Xiaogang Li
The corrosion of X80 pipeline steel in the presence of Bacillus cereus (B. cereus) was studied through electrochemical and surface analyses and live/dead staining. Scanning electron microscopy and live/dead straining results showed that a number of B. cereus adhered to the X80 steel. Electrochemical impedance spectroscopy showed that B. cereus could accelerate the corrosion of X80 steel. In addition, surface morphology observations indicated that B. cereus could accelerate pitting corrosion in X80 steel. The depth of the largest pits due to B...
December 24, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29328969/poly-3-6-diamino-9-ethylcarbazole-based-molecularly-imprinted-polymer-sensor-for-ultra-sensitive-and-selective-detection-of-17-%C3%AE-estradiol-in-biological-fluids
#12
Weilu Liu, Haifeng Li, Shangmin Yu, Jiaxing Zhang, Weihua Zheng, Liting Niu, Gengen Li
In this work, we reported the synthesis of 3, 6-diamino-9-ethylcarbazole and its application as a new monomer for preparation of molecularly imprinted polymer (MIP) electrochemical sensor. The as prepared MIP sensor exhibited ultrahigh sensitivity and selectivity for the detection of 17-β-estradiol in attomolar levels (1 × 10-18molL-1). The sensor works by detecting the change of the interfacial impedance that is derived from recognition of 17-β-estradiol on the MIP layer. The MIP sensor based on 3, 6-diamino-9-ethylcarbazole monomer revealed better performance than that of unmodified carbazole monomer...
January 4, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29328676/stabilizing-leaf-and-branch-compost-cutinase-lcc-with-glycosylation-mechanism-and-effect-on-pet-hydrolysis
#13
Abhijit N Shirke, Christine White, Jacob A Englaender, Allison Sophie Zwarycz, Glenn L Butterfoss, Robert J Linhardt, Richard A Gross
Cutinases are polyester hydrolases that show a remarkable capability to hydrolyze polyethylene terephthalate (PET) to its monomeric units. This revelation has stimulated research aimed at developing sustainable and green cutinase-catalyzed PET recycling methods. Leaf and branch compost cutinase (LCC) is particularly suited towards these ends given its relatively high PET hydrolysis activity and thermostability. Any practical enzymatic PET recycling application will require that the protein have kinetic stability at or above the PET glass transition temperature (Tg, i...
January 12, 2018: Biochemistry
https://www.readbyqxmd.com/read/29328630/effects-of-secondary-phases-on-the-high-performance-colossal-permittivity-in-titanium-dioxide-ceramics
#14
Chunlin Zhao, Jiagang Wu
The intensive demands of microelectronics and energy-storage applications are driving the increasing investigations on the colossal permittivity (CP) materials. In this study, we designed a new system of Dy and Nb co-doped TiO2 ceramics [(Dy0.5Nb0.5)xTi1-xO2] with the formation of secondary phases, and then the enhancement of overall dielectric properties (εr~5.0-6.5×104 and tan δ<8%) was realized in the broad composition range of 0.5%≤x≤5%. More importantly, effects of secondary phases on microstructure, dielectric properties, and stability were explored from the views of defect dipoles and internal barrier layer capacitance (IBLC) effect...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29328076/analysis-of-3d-plasmonic-circuits-by-using-surface-impedance-models
#15
Hoda Ameri, Reza Faraji-Dana
Novel and accurate global and local surface impedance models have been developed to analyze plasmonic circuits fast and efficiently. In the analysis procedure, first the metal strip in the plasmonic circuit is modeled by a surface impedance. Then, the calculated surface impedance is employed in the surface integral equation to analyze the plasmonic circuit such as a through line and line coupler. Accuracy of the numerical results is shown in comparison with a commercial simulation software. The number of unknowns as well as the computational time are also compared with the volume integral equation, and it is obvious that, using our proposed surface impedance models, the analysis will be much faster and more efficient...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29328010/-guideline-the-chronically-ill-and-work
#16
H Wind, I van der Heide, M Vooijs, D Bossen, J L Hoving, M H W Frings-Dresen
- The guideline 'The chronically ill and work' gives insight into disease-overarching factors and interventions that can promote or impede the participation in the work process of workers and those looking for work who have a chronic condition. - In particular, the guideline focuses on the role taken on by workers or those looking for work themselves during the process of keeping or resuming work. - The guideline gives recommendations for the daily practice of healthcare providers which are based on knowledge from disease-specific guidelines, the international literature and the experiences of healthcare providers, and workers and those looking for work with a chronic condition...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29327581/direct-measurement-of-large-electrocaloric-effect-in-ba-zrxti1-x-o3-ceramics
#17
Xiaodong Jian, Biao Lu, Dandan Li, Yingbang Yao, Tao Tao, Bo Liang, Jin-Hong Guo, Yi-Jiang Zeng, Jia-Le Chen, Sheng-Guo Lu
Barium zirconate titanate (Ba(ZrxTi1-x)O3-BZT) ceramics with Zr4+ content x of 5, 10, 15, 20, 25 and 30 mol%, were prepared using a solid-state-reaction approach. The microstructures, morphologies, and electric properties were characterized using XRD, SEM and impedance analysis methods, respectively. The dielectric analyses indicate that the BZT bulk ceramics show characteristics of phase transition from a normal ferroelectric to a relaxor ferroelectric with the increasing Zr4+ ionic content. The electrocaloric effect (ECE) adiabatic temperature change decreases with the increasing Zr4+ content...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327380/effects-of-deficiency-and-surplus-dietary-threonine-on-reproductive-performance-of-primiparous-pregnant-gilts
#18
M Shi, T Liu, T Li, H Wang, T Yuan, D Li, J Wang
Dietary threonine imbalance is known to impair reproductive performances of gestating sows, but the underlying mechanisms are largely unknown. In this study, effects of deficiency and surplus dietary threonine during gestation on reproductive performance, serum metabolites and hormones concentration, and colostral nutrient and immunoglobulin contents of primiparous sows were investigated. Ninety primiparous pregnant gilts were assigned to one of the three dietary treatments with different standardized ileal digestible threonine/lysine ratios at 0...
January 11, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29327023/a-step-towards-understanding-the-beneficial-influence-of-a-lipon-based-artificial-sei-on-silicon-thin-film-anodes-in-lithium-ion-batteries
#19
A Reyes Jiménez, R Nölle, R Wagner, J Hüsker, M Kolek, R Schmuch, M Winter, T Placke
In this work, we present a comprehensive study on the influence of lithium phosphorus oxynitride (LIPON) as a possible "artificial SEI layer" on the electrochemical performance of pure silicon (Si) thin film electrodes for a possible application in microbatteries or on-chip batteries. Si thin film anodes (140 nm) with and without an additional amorphous LIPON surface layer of different thicknesses (100-300 nm) were prepared by magnetron sputter deposition. The LIPON surface coating was characterized thoroughly by means of electrochemical impedance spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy and atomic force microscopy...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29326161/sumo2-3-modification-of-activating-transcription-factor-5-atf5-controls-its-dynamic-translocation-at-the-centrosome
#20
Yunsheng Yuan, Kari Gaither, Eugene Kim, Edward Liu, Ming Hu, Kathy Lengel, Dongmeng Qian, Yidi Xu, Bin Wang, Henning Knipprath, David Liu
Activating transcription factor 5 (ATF5) is a member of the ATF/CREB family of transcription factors. ATF5 regulates stress responses and cell survival, proliferation, and differentiation and also plays a role in viral infections, cancer, diabetes, schizophrenia, and the olfactory system. Moreover, it was found to also have a critical, cell cycle-dependent structural function at the centrosome. However, the mechanism that controls ATF5's localization at the centrosome is unclear. Here, we report that ATF5 is SUMO2/3- modified at a conserved SUMO-targeting consensus site in various types of mammalian cells...
January 11, 2018: Journal of Biological Chemistry
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