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https://www.readbyqxmd.com/read/28325021/evaluation-of-lung-ventilation-distribution-in-chronic-obstructive-pulmonary-disease-patients-using-the-global-inhomogeneity-index
#1
F Trenk, L Mendes, P Carvalho, R P Paiva, J Henriques, N Maglaveras, I Chouvarda, V Tsara, C A Teixeira
The global inhomogeneity (GI) index is a electrical impedance tomography (EIT) parameter that quantifies the tidal volume distribution within the lung. In this work the global inhomogeneity index was computed for twenty subjects in order to evaluate his potential use in the detection and follow up of chronic obstructive pulmonary disease (COPD) patients. EIT data of 17 subjects were acquired: 14 patients with the main diagnoses of COPD and 3 healthy subjects which served as a control group. Two or three datasets of around 30 seconds were acquired at 33 scans/s and analysed for each subject...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324964/gastric-mucosa-injury-quantification-in-an-ischemia-reperfusion-experimental-model
#2
E Pena-Mercado, M Garcia-Lorenzana, E Arechaga, C H Gonzalez-de la Rosa, N E Beltran
Gastric ischemia - reperfusion (I/R) injury is an important clinical problem, which is developed in more than 80% of critically ill patients. I/R is caused by interruption of blood supply to an organ or tissue followed by blood reflow into the exposed area, leading to multiple organ failure and death. Gastric reactance has been proposed to measure tissue injury caused by ischemia. The present study evaluates a new method to quantify gastric tissue damage due to I/R, and assess its relation to gastric reactance changes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324960/design-and-characterization-of-a-torque-controllable-actuator-for-knee-assistance-during-sit-to-stand
#3
Max K Shepherd, Elliott J Rouse
Individuals with post-stroke hemiparesis often have difficulty standing out of a chair. One way to potentially improve sit-to-stand is to provide knee extension assistance using a powered knee exoskeleton. An exoskeleton providing unilateral, partial assistance during sit-to-stand would need to be torque-controllable. There are no knee exoskeletons on the market suitable for conducting experiments assisting stroke patients with sit-to-stand, so to enable such experiments a research device was developed. The purpose of this report is to present the design of a novel knee exoskeleton actuator that uses a fiberglass leaf spring in series to improve torque-controllability, and present a characterization of the actuator performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324938/application-of-semi-supervised-deep-learning-to-lung-sound-analysis
#4
Daniel Chamberlain, Rahul Kodgule, Daniela Ganelin, Vivek Miglani, Richard Ribon Fletcher
The analysis of lung sounds, collected through auscultation, is a fundamental component of pulmonary disease diagnostics for primary care and general patient monitoring for telemedicine. Despite advances in computation and algorithms, the goal of automated lung sound identification and classification has remained elusive. Over the past 40 years, published work in this field has demonstrated only limited success in identifying lung sounds, with most published studies using only a small numbers of patients (typically N<;20) and usually limited to a single type of lung sound...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324722/incorporation-of-dielectric-constituents-to-construct-ternary-heterojunction-structures-for-high-efficiency-electromagnetic-response
#5
Bin Quan, Guoyue Xu, Daoran Li, Wei Liu, Guangbin Ji, Youwei Du
To satisfy the diverse requirements of low reflection and high absorption of microwave attenuation, the construction of multiple heterojunction structure is imperative. On the one hand, the impedance mismatching could be ameliorated via the addition of new component; on the other hand, the multiple interface polarizations derived from the architecture of heterojunction make for the dissipation of microwave. In this work, the ternary TiO2/RGO/Fe2O3 composites exhibit tremendous superiority compared with single TiO2 or RGO no matter the absorption coefficient or effective bandwidth...
March 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28323572/bilateral-changes-in-deep-tissue-environment-after-manual-lymphatic-drainage-in-patients-with-breast-cancer-treatment-related-lymphedema
#6
Paula M C Donahue, Rachelle Crescenzi, Allison O Scott, Vaughn Braxton, Aditi Desai, Seth A Smith, John Jordi, Ingrid M Meszoely, Ana M Grau, Rondi M Kauffmann, Raeshell S Sweeting, Kandace Spotanski, Sheila H Ridner, Manus J Donahue
BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD)...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28323413/designing-morphology-in-epitaxial-silicon-nanowires-the-role-of-gold-surface-chemistry-and-phosphorus-doping
#7
Seokhyoung Kim, David J Hill, Christopher W Pinion, Joseph D Christesen, James R McBride, James F Cahoon
Vertically-aligned semiconductor nanowires (NWs) have many potential applications for NW-based technologies, ranging from solar cells to intracellular sensors. Aligned NWs can be fabricated by top-down etching of planar wafers or synthesized from the bottom-up using the vapor-liquid-solid (VLS) mechanism to induce epitaxial growth on lattice-matched substrates. The VLS process permits the modulation of dopants along the NW growth axis, which, if combined with dopant-dependent wet-chemical etching, can be used to encode precise morphology...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28320043/effects-of-ranolazine-in-a-model-of-doxorubicin-induced-left-ventricle-diastolic-dysfunction
#8
Donato Cappetta, Grazia Esposito, Raffaele Coppini, Elena Piegari, Rosa Russo, Loreta Pia Ciuffreda, Alessia Rivellino, Lorenzo Santini, Concetta Rafaniello, Cristina Scavone, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Antonella De Angelis
BACKGROUND AND PURPOSE: Doxorubicin (DOXO) is a highly effective anticancer drug but its clinical application is impeded by cardiotoxicity. Asymptomatic diastolic dysfunction can be the earliest manifestation of DOXO cardiotoxicity. Therefore, a search for therapeutic intervention that can interfere with early manifestations and possibly prevent late cardiotoxicity is warranted. Increased DOXO-dependent reactive oxygen species may explain, in part, Ca(2+) and Na(+) overload that contributes to diastolic dysfunction and development of heart failure...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28319904/sensitivity-enhancement-of-graphene-zinc-oxide-nanocomposite-based-electrochemical-impedance-genosensor-for-single-stranded-rna-detection
#9
Sze Shin Low, Hwei-San Loh, Jian Sheng Boey, Poi Sim Khiew, Wee Siong Chiu, Michelle T T Tan
An efficient electrochemical impedance genosensing platform has been constructed based on graphene/zinc oxide nanocomposite produced via a facile and green approach. Highly pristine graphene was synthesised from graphite through liquid phase sonication and then mixed with zinc acetate hexahydrate for the synthesis of graphene/zinc oxide nanocomposite by solvothermal growth. The as-synthesised graphene/zinc oxide nanocomposite was characterised with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray diffractometry (XRD) to evaluate its morphology, crystallinity, composition and purity...
February 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319897/dialysis-membrane-enforced-microelectrode-array-measurement-of-diverse-gut-electrical-activity
#10
Naoko Iwata, Takumi Fujimura, Chiho Takai, Kei Odani, Shin Kawano, Shinsuke Nakayama
A variety of electrical activities occur depending on the functional state in each section of the gut, but the application of microelectrode array (MEA) is rather limited. We thus developed a dialysis membranes-enforced technique to investigate diverse and complex spatio-temporal electrical activity in the gut. Muscle sheets isolated from the gastrointestinal (GI) tract of mice along with a piece of dialysis membrane were woven over and under the strings to fix them to the anchor rig, and mounted on an 8×8 MEA (inter-electrode distance=150µm)...
March 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319679/evaluation-of-body-composition-with-bioimpedence-a-comparison-between-athletic-and-non-athletic-children
#11
Domenico Meleleo, Nicola Bartolomeo, Liliana Cassano, Alessandro Nitti, Giovanna Susca, Giuseppina Mastrototaro, Umberto Armenise, Annapaola Zito, Fiorella Devito, Pietro Scicchitano, Marco Matteo Ciccone
PURPOSE: Conventional Bioelectrical Impedance Analysis (BIA) or Bioelectrical Impedance Vector Analysis (BIVA) can provide direct evaluations of body composition. The purpose of this study was to evaluate lean and fat mass (FM), and hydration of children involved in daily competitive sports. METHODS: 190 non-athletic [8.2-10.5 years] and 29 competitive children [8.0-10.5 years] were enrolled. They were evaluated: at baseline (t0), 6 months (t1) and one year (t2)...
March 20, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28319030/ischemic-small-intestine-in-vivo-versus-ex-vivo-bioimpedance-measurements
#12
Runar James Strand-Amundsen, Henrik Reims, Christian Tronstad, Havard Kalvoy, Orjan Martinsen, Jan Hogetveit, Tom Erik Ruud, Tor Inge Tønnessen
Bioimpedance has been used to investigate changes in electrical parameters during ischemia in various tissues. The small intestine is a multi-layered structure, with several distinct tissue types, and ischemia related changes occur at different times in the different intestinal layers. When investigating how the electrical properties in the small intestine is affected by ischemia, some researchers have used ex-vivo models while others have used in-vivo models. In this study, we compare ischemic time development of electrical parameters in ischemic in-vivo versus ex-vivo small intestine...
March 20, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28318821/snf2-family-protein-fft3-suppresses-nucleosome-turnover-to-promote-epigenetic-inheritance-and-proper-replication
#13
Nitika Taneja, Martin Zofall, Vanivilasini Balachandran, Gobi Thillainadesan, Tomoyasu Sugiyama, David Wheeler, Ming Zhou, Shiv I S Grewal
Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing. However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we identify Fft3, a fission yeast homolog of the mammalian SMARCAD1 SNF2 chromatin remodeler, as a factor uniquely required for heterochromatin inheritance, rather than for de novo assembly. Importantly, we find that Fft3 suppresses turnover of histones at heterochromatic loci to facilitate epigenetic transmission of heterochromatin in cycling cells...
March 8, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28318631/the-antihelmenthic-phosphate-niclosamide-impedes-renal-fibrosis-by-inhibiting-homeodomain-interacting-protein-kinase-2-expression
#14
Xiaoyan Chang, Xin Zhen, Jixing Liu, Xiaomei Ren, Zheng Hu, Zhanmei Zhou, Fengxin Zhu, Ke Ding, Jing Nie
Renal fibrosis is the final common pathway of all varieties of progressive chronic kidney disease. However, there are no effective therapies to prevent or slow the progression of renal fibrosis. Niclosamide is a US Food and Drug Administration-approved oral antihelminthic drug used for treating most tapeworm infections. Here, we demonstrated that phosphate niclosamide, the water-soluble form of niclosamide, significantly reduced proteinuria, glomerulosclrotic lesions, and interstitial fibrosis in a murine model of adriamycin nephropathy...
March 16, 2017: Kidney International
https://www.readbyqxmd.com/read/28318143/designing-squaraines-to-control-charge-injection-and-recombination-processes-in-nio-based-dye-sensitized-solar-cells
#15
Oliver Langmar, Davide Saccone, Anna Amat, Simona Fantacci, Guido Viscardi, Claudia Barolo, Ruben Costa, Dirk Michael Guldi
Herein, the synthesis of a novel family of squaraines (SQ) and their application in p-type dye-sensitized solar cells (DSSC) is presented. In particular, two sets of SQs were designed. The SQs have been characterized by using a joint theoretical, photophysical and electrochemical approach. Importantly, the presence of different central groups forces them into a frozen cis (dicyanovinyl group) or a trans (oxygen group) conformation. Based on the latter, the current work enables the direct comparison between cis and trans isomers, as well as the impact of a different number of anchors...
March 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28317995/in-situ-deprotection-and-dynamic-covalent-assembly-using-a-dual-role-catalyst
#16
T Wei, J C Furgal, T F Scott
Utilization of constituent molecular precursors bearing covalently coreactive functional groups for self-assembly risks premature reaction, impeding synthetic and purification efforts. To prevent premature amine-aldehyde condensation for oligomers bearing both groups, we employ a dual-role Lewis acid catalyst for both in situ acetal deprotection and subsequent imine exchange, effecting oligomer assembly.
March 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28317985/hierarchical-porous-ni-boehmite-nickel-aluminum-oxide-flakes-with-enhanced-microwave-absorption-ability
#17
Biao Zhao, Junwei Liu, Xiaoqin Guo, Wanyu Zhao, Luyang Liang, Chao Ma, Rui Zhang
In this article, composites consisting of porous Ni cores coated with boehmite/nickel aluminum oxide nanoflakes were successfully prepared by a versatile method. The crystal constituents and shapes of the boehmite/nickel aluminum oxide nanoflakes were strongly influenced by reaction temperature, and their microwave absorption properties were investigated in terms of complex permittivity and permeability. The results reveal that the composites comprising porous Ni cores coated with boehmite/nickel aluminum oxide synthesized at 180 °C present superior absorption properties...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28317954/surface-chemistry-of-pure-tetragonal-zro2-and-gas-phase-dependence-of-the-tetragonal-to-monoclinic-zro2-transformation
#18
Eva-Maria Köck, Michaela Kogler, Thomas Götsch, Lukas Schlicker, Maged F Bekheet, Andrew Doran, Aleksander Gurlo, Bernhard Klötzer, Benedikt Petermüller, Daniel Schildhammer, Nevzat Yigit, Simon Penner
The surface chemical properties of undoped tetragonal ZrO2 and the gas-phase dependence of the tetragonal-to-monoclinic transformation are studied using a tetragonal ZrO2 polymorph synthesized via a sol-gel method from an alkoxide precursor. The obtained phase-pure tetragonal ZrO2 is defective and strongly hydroxylated with pronounced Lewis acidic and Brønsted basic surface sites. Combined in situ FT-infrared and electrochemical impedance measurements reveal effective blocking of coordinatively unsaturated sites by both CO and CO2, as well as low conductivity...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28317927/observation-of-acoustic-dirac-like-cone-and-double-zero-refractive-index
#19
Marc Dubois, Chengzhi Shi, Xuefeng Zhu, Yuan Wang, Xiang Zhang
Zero index materials where sound propagates without phase variation, holds a great potential for wavefront and dispersion engineering. Recently explored electromagnetic double zero index metamaterials consist of periodic scatterers whose refractive index is significantly larger than that of the surrounding medium. This requirement is fundamentally challenging for airborne acoustics because the sound speed (inversely proportional to the refractive index) in air is among the slowest. Here, we report the first experimental realization of an impedance matched acoustic double zero refractive index metamaterial induced by a Dirac-like cone at the Brillouin zone centre...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28317677/trends-in-cataract-surgery-training-curricula
#20
Mona Lotfipour, Ramunas Rolius, Erik B Lehman, Seth M Pantanelli, Ingrid U Scott
PURPOSE: To evaluate trends in cataract surgery training curricula and factors affecting timing of resident participation as a primary surgeon. SETTING: Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA. DESIGN: Cross-sectional study of anonymous survey results. METHODS: A description of the study and link to an online survey was e-mailed to program directors of each ophthalmology residency training program accredited by the Accreditation Council for Graduate Medical Education (ACGME)...
January 2017: Journal of Cataract and Refractive Surgery
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