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transient receptor vanilloid 1

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https://www.readbyqxmd.com/read/29791836/trpv4-mediates-hypotonic-inhibition-of-central-osmosensory-neurons-via-taurine-gliotransmission
#1
Sorana Ciura, Masha Prager-Khoutorsky, Zahra S Thirouin, Joshua C Wyrosdic, James E Olson, Wolfgang Liedtke, Charles W Bourque
The maintenance of hydromineral homeostasis requires bidirectional detection of changes in extracellular fluid osmolality by primary osmosensory neurons (ONs) in the organum vasculosum laminae terminalis (OVLT). Hypertonicity excites ONs in part through the mechanical activation of a variant transient receptor potential vanilloid-1 channel (dn-Trpv1). However, the mechanism by which local hypotonicity inhibits ONs in the OVLT remains unknown. Here, we show that hypotonicity can reduce the basal activity of dn-Trpv1 channels and hyperpolarize acutely isolated ONs...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29772784/capsaicin-in-metabolic-syndrome
#2
REVIEW
Sunil K Panchal, Edward Bliss, Lindsay Brown
Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions. Insulin resistance and obesity, being the major components of metabolic syndrome, increase the risk for the development of cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. In vitro and pre-clinical studies have established the effectiveness of low-dose dietary capsaicin in attenuating metabolic disorders...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29768271/direct-potentiation-of-capsaicin-current-by-histamine-and-its-effect-by-suplatast-on-rat-trigeminal-ganglia-neurons
#3
Jian-Rong Zhou, Tetsuya Shirasaki, Fumio Soeda, Kazumi Yokomizo, Kazuo Takahama
In this study, we investigated the effect of histamine on capsaicin-induced current and its influence by suplatast in rat trigeminal ganglia neurons using a patch-clamp technique. We found that histamine directly potentiated capsaicin-induced currents in rat sensory neurons, and suplatast had little effect on this potentiation. Since it has been known that suplatast suppresses histamine release from mast cells, it is possible that suplatast inhibits the activation of nociceptive fibers in the pathological condition via prevention of histamine-induced potentiation of the transient receptor potential vanilloid 1 receptor-mediated currents...
May 16, 2018: Pharmacology
https://www.readbyqxmd.com/read/29765535/effects-of-cb2-and-trpv1-receptors-stimulation-in-pediatric-acute-t-lymphoblastic-leukemia
#4
Francesca Punzo, Iolanda Manzo, Chiara Tortora, Elvira Pota, Velia D' Angelo, Giulia Bellini, Alessandra Di Paola, Federica Verace, Fiorina Casale, Francesca Rossi
T-Acute Lymphoblastic Leukemia (T-ALL) is less frequent than B-ALL, but it has poorer outcome. For this reason new therapeutic approaches are needed to treat this malignancy. The Endocannabinoid/Endovanilloid (EC/EV) system has been proposed as possible target to treat several malignancies, including lymphoblastic diseases. The EC/EV system is composed of two G-Protein Coupled Receptors (CB1 and CB2), the Transient Potential Vanilloid 1 (TRPV1) channel, their endogenous and exogenous ligands and enzymes. CB1 is expressed mainly in central nervous system while CB2 predominantly on immune and peripheral cells, therefore we chose to selectively stimulate CB2 and TRPV1...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765419/low-magnitude-of-compression-enhances-biosynthesis-of-mesenchymal-stem-cells-towards-nucleus-pulposus-cells-via-the-trpv4-dependent-pathway
#5
Yibo Gan, Bing Tu, Pei Li, Jixing Ye, Chen Zhao, Lei Luo, Chengmin Zhang, Zetong Zhang, Linyong Zhu, Qiang Zhou
Mesenchymal stem cell- (MSC-) based therapy is regarded as a promising tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to promote the biosynthesis of MSC to meet the requirement of NP regeneration. The purpose of this study was to optimize the compressive magnitude to enhance the extracellular matrix (ECM) deposition towards discogenesis of MSCs. Thus, we constructed a 3D culture model for MSCs to bear different magnitudes of compression for 7 days (5%, 10%, and 20% at the frequency of 1...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29757072/lactobacillus-plantarum-ys-3-prevents-activated-carbon-induced-constipation-in-mice
#6
Xin Zhao, Ruokun Yi, Yu Qian, Kun-Young Park
The aim of this study was to determine the effects of Lactobacillus plantarum YS-3 (LP-YS3) on activated carbon-induced constipation in Kunming mice. The results of the experiment show that the antigastric acid activity and bile salt tolerance of LP-YS3 were stronger than those of Lactobacillus bulgaricus (LB). LP-YS3 inhibited loss of body weight caused by constipation and further reductions in fecal weight, particle number, and water content in mice. Moreover, LP-YS3 elevated the gastrointestinal transit rate and reduced the time required for initial black stool defecation...
May 14, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29735636/potential-protective-mechanism-in-the-cardiac-microvascular-injury
#7
Xiuchuan Li, Juanni Hou, Jin Du, Jian Feng, Yi Yang, Yang Shen, Sha Chen, Juan Feng, Dachun Yang, De Li, Haifeng Pei, Yongjian Yang
Cardiac microvascular injury often occurs in patients with type 2 diabetes mellitus (T2DM) who develop hyperglycemia and hyperlipidemia. However, besides reported contradictory roles in cardiac diseases, the function of TRPV1 (transient receptor potential vanilloid 1) in cardiac microvessels is not well defined. This study was performed to determine the detailed role of TRPV1 in cardiac microvascular endothelial cells (CMECs) in T2DM. T2DM mice were established by multiple injections of low-dose streptozotocin and high-fat feeding...
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29734380/mitochondrial-modulation-induced-activation-of-vagal-sensory-neuronal-subsets-by-antimycin-a-but-not-cccp-or-rotenone-correlates-with-mitochondrial-superoxide-production
#8
Katherine R Stanford, Thomas E Taylor-Clark
Inflammation causes nociceptive sensory neuron activation, evoking debilitating symptoms and reflexes. Inflammatory signaling pathways are capable of modulating mitochondrial function, resulting in reactive oxygen species (ROS) production, mitochondrial depolarization and calcium release. Previously we showed that mitochondrial modulation with antimycin A, a complex III inhibitor, selectively stimulated nociceptive bronchopulmonary C-fibers via the activation of transient receptor potential (TRP) ankyrin 1 (A1) and vanilloid 1 (V1) cation channels...
2018: PloS One
https://www.readbyqxmd.com/read/29734335/pomc-neurons-in-heat-a-link-between-warm-temperatures-and-appetite-suppression
#9
Maria A Vicent, Conor L Mook, Matthew E Carter
When core body temperature increases, appetite and food consumption decline. A higher core body temperature can occur during exercise, during exposure to warm environmental temperatures, or during a fever, yet the mechanisms that link relatively warm temperatures to appetite suppression are unknown. A recent study in PLOS Biology demonstrates that neurons in the mouse hypothalamus that express pro-opiomelanocortin (POMC), a neural population well known to suppress food intake, also express a temperature-sensitive ion channel, transient receptor potential vanilloid 1 (TRPV1)...
May 7, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29732984/knockout-of-trpv1-exacerbates-left-ventricular-diastolic-dysfunction-induced-by-a-high-fat-diet-in-mice
#10
Beihua Zhong, Jack Rubinstein, Shuangtao Ma, Donna H Wang
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) channels in sensory nerves have anti-oxidative properties and counteract obesity and diabetes that are associated with diastolic dysfunction with preserved ejection fraction. We tested the hypothesis that TRPV1 knockout exacerbates high-fat diet (HFD)-induced glucose intolerance and diastolic dysfunction. METHOD: Trpv1-/- and wild-type (WT) mice were fed chow diet or HFD for 20 weeks. Then, we performed the intraperitoneal glucose tolerance test, measured the heart function through transthoracic echocardiography and Langendorff heart perfusion system, analyzed cardiac histology, and measured the myocardial superoxide production and the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases...
May 3, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29728656/conformational-plasticity-in-the-selectivity-filter-of-the-trpv2-ion-channel
#11
Lejla Zubcevic, Son Le, Huanghe Yang, Seok-Yong Lee
Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat and are involved in various physiological processes. In contrast to the architecturally related voltage-gated cation channels, TRPV1 and TRPV2 subtypes possess another activation gate at the selectivity filter that can open widely enough to permeate large organic cations. Despite recent structural advances, the mechanism of selectivity filter gating and permeation for both metal ions and large molecules by TRPV1 or TRPV2 is not well known...
May 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29723849/the-mechanism-of-action-of-zingerone-in-the-pacemaker-potentials-of-interstitial-cells-of-cajal-isolated-from-murine-small-intestine
#12
Jung Nam Kim, Hyun Jung Kim, Iksung Kim, Yun Tai Kim, Byung Joo Kim
BACKGROUND/AIMS: Zingerone, a major component found in ginger root, is clinically effective for the treatment of various diseases. Interstitial cells of Cajal (ICCs) are the pacemaker cells responsible for slow waves in the gastrointestinal (GI) tract. We investigated the effects of zingerone on the pacemaker potentials of ICCs to assess its mechanisms of action and its potential as a treatment for GI tract motility disorder. METHODS: We isolated ICCs from small intestines, and the whole-cell patch-clamp configuration was used to record the pacemaker potentials in cultured ICCs...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29722529/targeting-transient-receptor-potential-vanilloid-1-trpv1-channel-softly-the-discovery-of-passerini-adducts-as-a-topical-treatment-for-inflammatory-skin-disorders
#13
Marta Serafini, Alessia Griglio, Silvio Aprile, Fabio Seiti, Cristina Travelli, Franco Pattarino, Giorgio Grosa, Giovanni Sorba, Armando A Genazzani, Sara Gonzales-Rodriguez, Laura Butron, Isabel Devesa, Asia Fernández-Carvajal, Tracey Pirali, Antonio Ferrer-Montiel
Despite being an old molecule, capsaicin is still a hot topic in scientific community and the development of new capsaicinoids is a promising pharmacological approach in the management of skin disorders related to inflammation and pruritus. Here we report the synthesis and the evaluation of capsaicin soft drugs that undergo deactivation by the hydrolyzing activity of skin esterases. The implanting of an ester group in the lipophilic moiety of capsaicinoids by the Passerini multicomponent reaction affords both agonists and antagonists that retain transient receptor potential vanilloid 1 channel (TRPV1) modulating activity and, at the same time, are susceptible to hydrolysis...
May 3, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29719445/mechanisms-involved-in-adenosine-pharmacological-preconditioning-induced-cardioprotection
#14
REVIEW
Lovedeep Singh, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh Jaggi
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29715454/-effect-of-polygodial-and-its-direct-derivatives-on-the-mammalian-na-k-atpase-activity
#15
Diogo Gomes Garcia, Cassiano Felippe Gonçalves-de-Albuquerque, Camila Ignácio da Silva, Robert Kiss, Ramesh Dasari, Sunena Chandra, Alexander Kornienko, Patricia Burth
The sesquiterpene polygodial is an agonist of the transient receptor potential vanilloid 1 (TRPV1). Our group recently reported the synthesis and anticancer effects of polygodial and its derivatives, and showed that these compounds retain activity against apoptosis- and multidrug-resistant cancer cells. Herein, we tested the inhibitory effect of these compounds on the activity of the enzyme Na+ /K+ -ATPase (NKA) from kidney (α1 isoform) and brain (α2 and α3 isoforms) guinea pig extracts. Polygodial (1) displayed a dose-dependent inhibition of both kidney and brain purified NKA preparations, with higher sensitivity for the cerebral isoforms...
April 28, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29713744/skin-neurogenic-inflammation
#16
REVIEW
Jae Eun Choi, Anna Di Nardo
The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than others in the generation of itch. The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation...
April 30, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29701904/trpv4-activates-cytosolic-phospholipase-a-2-via-ca-2-dependent-pkc-erk1-2-signaling-in-controlling-hypertensive-contraction
#17
Hongjuan Li, Hao Kan, Xiaodong Zhang, Zhenyu Yang, Jian Jin, Peng Zhang, Xin Ma
Activation of TRPV4 (transient receptor potential vanilloid 4) has been reported to result in endothelium-dependent contraction in the aortae of hypertensive mice. This contraction involved increased cPLA2 (cytosolic phospholipase A2 ) activity. The mechanism by which TRPV4 regulates cPLA2 activity to induce contraction in hypertension, however, is unknown. Through measurements of arterial tension and protein level, we showed that high salt diet induced hypertension increases activity of PKC (protein kinase C) and ERK1/2 (extracellular signal-regulated kinase 1/2)...
April 27, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29698108/capsaicin-based-analgesic-balm-attenuates-the-skeletal-muscle-metaboreflex-in-healthy-humans
#18
Lauro C Vianna, Igor A Fernandes, Thales C Barbosa, André L Teixeira, Antonio Claudio Lucas da Nóbrega
The exercise pressor reflex (EPR) is comprised from group III and IV skeletal muscle afferents and is one of the principal mediators of the cardiovascular response to exercise. In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR. However, whether these findings can be extrapolated to humans remain unknown...
April 26, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29689050/activation-of-temperature-sensitive-trpv1-like-receptors-in-arc-pomc-neurons-reduces-food-intake
#19
Jae Hoon Jeong, Dong Kun Lee, Shun-Mei Liu, Streamson C Chua, Gary J Schwartz, Young-Hwan Jo
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To show expression of TRPV1-like receptors in ARC POMC neurons, we use single-cell reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, electrophysiology, TRPV1 knock-out (KO), and TRPV1-Cre knock-in mice...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29683271/piperine-promotes-glucose-uptake-through-ros-dependent-activation-of-the-camkk-ampk-signaling-pathway-in-skeletal-muscle
#20
Ayumi Maeda, Takeshi Shirao, Daishi Shirasaya, Yasukiyo Yoshioka, Yoko Yamashita, Mitsugu Akagawa, Hitoshi Ashida
SCOPE: The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide. Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of associated complications. Spices possess various health beneficial effects on humans. The aim of this study was to search for spices that can promote glucose uptake and to elucidate the underlying molecular mechanism(s). METHODS AND RESULTS: Among 24 spice extracts, the extracts from black and white pepper significantly increased glucose uptake in L6 myotubes...
April 23, 2018: Molecular Nutrition & Food Research
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