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Suzannah M Schmidt-Malan, Melissa J Karau, Julia Cede, Kerryl E Greenwood-Quaintance, Cassandra L Brinkman, Jayawant N Mandrekar, Robin Patel
Bacterial biofilms are difficult to treat using available antimicrobial agents, so new antibiofilm strategies are needed. We previously showed that 20, 200, and 2,000 μA of electrical current reduced bacterial biofilms of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa. Here, we tested continuous direct current at lower amperages, intermittent direct current, and combinations of surface materials (Teflon or titanium) and electrode compositions (stainless steel, graphite, titanium, or platinum) against S...
August 2015: Antimicrobial Agents and Chemotherapy
Jose L Del Pozo, Mark S Rouse, Gorane Euba, Cheol-In Kang, Jayawant N Mandrekar, James M Steckelberg, Robin Patel
Treatment with low-amperage (200 microA) electrical current was compared to intravenous doxycycline treatment or no treatment in a rabbit model of Staphylococcus epidermidis chronic foreign body osteomyelitis to determine if the electricidal effect is active in vivo. A stainless steel implant and 10(4) CFU of planktonic S. epidermidis were placed into the medullary cavity of the tibia. Four weeks later, rabbits were assigned to one of three groups with treatment administered for 21 days. The groups included those receiving no treatment (n = 10), intravenous doxycycline (n = 14; 8 mg/kg of body weight three times per day), and electrical current (n = 15; 200 microA continuous delivery)...
October 2009: Antimicrobial Agents and Chemotherapy
Jose L del Pozo, Mark S Rouse, Jayawant N Mandrekar, James M Steckelberg, Robin Patel
The activity of electrical current against planktonic bacteria has previously been demonstrated. The short-term exposure of the bacteria in biofilms to electrical current in the absence of antimicrobials has been shown to have no substantial effect; however, longer-term exposure has not been studied. A previously described in vitro model was used to determine the effect of prolonged exposure (i.e., up to 7 days) to low-intensity (i.e., 20-, 200-, and 2,000-microampere) electrical direct currents on Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms...
January 2009: Antimicrobial Agents and Chemotherapy
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