Monika Dzięgielewska, Marzenna Bartoszewicz, Marta Książczyk, Bartłomiej Dudek, Malwina Brożyna, Patrycja Szymczyk-Ziółkowska, Piotr Gruber, Jacek Pawlak, Weronika Kozłowska, Sylwia Zielińska, Jędrzej Fischer, Aleksandra Woytoń, Adam Junka
Biofilm-related ocular infections can lead to vision loss and are difficult to treat with antibiotics due to challenges with application and increasing microbial resistance. In turn, the design and testing of new synthetic drugs is a time- and cost-consuming process. Therefore, in this work, for the first time, we assessed the in vitro efficacy of the plant-based abietic acid molecule, both alone and when introduced to a polymeric cellulose carrier, against biofilms formed by Staphylococcus aureus , Pseudomonas aeruginosa , and Candida albicans in standard laboratory settings as well as in a self-designed setting using the topologically challenging surface of the artificial eye...
January 26, 2024: International Journal of Molecular Sciences