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https://www.readbyqxmd.com/read/28432976/cuticular-wax-coverage-and-composition-differ-among-organs-of-taraxacum-officinale
#1
Yanjun Guo, Lucas Busta, Reinhard Jetter
Primary plant surfaces are coated with hydrophobic cuticular waxes to minimize non-stomatal water loss. Wax compositions differ greatly between plant species and, in the few species studied systematically so far, also between organs, tissues, and developmental stages. However, the wax mixtures of more species in diverse plant families must be investigated to assess overall wax variability, and ultimately to correlate organ-specific composition with local water barrier properties. Here, we present comprehensive analyses of the waxes covering five organs of Taraxacum officinale (dandelion), to help close a gap in our understanding of wax chemistry in the Asteraceae family...
April 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28432950/effects-of-chlortetracycline-and-copper-on-tetracyclines-and-copper-resistance-genes-and-microbial-community-during-swine-manure-anaerobic-digestion
#2
Rui Wang, Meixue Chen, Feng Feng, Junya Zhang, Qianwen Sui, Juan Tong, Yuansong Wei, Dongbin Wei
As antibiotic and heavy metals are over used in the livestock industry, animal manure is a reservoir of antibiotic resistance genes (ARGs). Anaerobic digestion has been reported to have the potential to reduce ARGs. However, few studies investigated whether reduction of ARGs would be affected by different external pressures including antibiotics and heavy metals during anaerobic digestion. The purpose of this study was thus to investigate effects of both chlortetracycline (CTC) and Cu on reduction of ARGs, heavy metal resistance genes (HMRGs) and mobile genetic elements (MGEs) during the swine manure anaerobic digestion...
March 25, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28432891/modification-of-an-existing-in%C3%A2-vitro-method-to-predict-relative-bioavailable-arsenic-in-soils
#3
Shane Whitacre, Nicholas Basta, Brooke Stevens, Valerie Hanley, Richard Anderson, Kirk Scheckel
The soil matrix can sequester arsenic (As) and reduces its exposure by soil ingestion. In vivo dosing studies and in vitro gastrointestinal (IVG) methods have been used to predict relative bioavailable (RBA) As. Originally, the Ohio State University (OSU-IVG) method predicted RBA As for soils exclusively from mining and smelting sites with a median of 5,636 mg As kg(-1). The objectives of the current study were to (i) evaluate the ability of the OSU-IVG method to predict RBA As for As contaminated soils with a wider range of As content and As contaminant sources, and (ii) evaluate a modified extraction procedure's ability to improve prediction of RBA As...
April 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28432781/cognitive-functioning-and-emotion-processing-in-breast-cancer-survivors-and-controls-an-erp-pilot-study
#4
Janine Wirkner, Mathias Weymar, Andreas Löw, Carmen Hamm, Anne-Marie Struck, Clemens Kirschbaum, Alfons O Hamm
Diagnosis and treatment of breast cancer is a very emotionally aversive and stressful life event, which can lead to impaired cognitive functioning and mental health. Breast cancer survivors responding with repressive emotion regulation strategies often show less adaptive coping and adverse outcomes. We investigated cognitive functioning and neural correlates of emotion processing using ERPs. Self-report measures of depression, anxiety, and fatigue, as well as hair cortisol as an index of chronic stress, were assessed...
April 22, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28432779/nmdar-independent-hippocampal-long-term-depression-impairment-after-status-epilepticus-in-a-lithium-pilocarpine-model-of-temporal-lobe-epilepsy
#5
Andrey D Ivanov, Aleksey V Zaitsev
Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits. Despite numerous existing studies on various animal models, the mechanisms of these deficits remain largely unclear. A specific form of long-term synaptic efficacy changes - long-term depression (LTD) - is thought to play an important role in memory formation and learning. However, extremely little is known about the possible alteration of LTD induction and dynamics after a status epilepticus (SE). In the present work we investigated the acute and delayed effects of lithium-pilocarpine-induced SE on NMDAR-dependent and NMDAR-independent hippocampal LTD in vitro...
April 22, 2017: Synapse
https://www.readbyqxmd.com/read/28432691/tenapanor-administration-and-the-activity-of-the-h-coupled-transporter-pept1-in-healthy-volunteers
#6
Susanne Johansson, David P Rosenbaum, Johan Palm, Bergur Stefansson, Mikael Knutsson, Eleanor A Lisbon, Constanze Hilgendorf
AIM: Tenapanor (RDX5791/AZD1722), an inhibitor of gastrointestinal Na(+) /H(+) exchanger NHE3, is being evaluated for the treatment of patients with constipation-predominant irritable bowel syndrome and the treatment of hyperphosphataemia in patients with chronic kidney disease on dialysis. By reducing intestinal H(+) secretion, inhibition of NHE3 by tenapanor could indirectly affect H(+) -coupled transporter activity, leading to drug-drug interactions. We investigated the effect of tenapanor on the activity of the H(+) -coupled peptide transporter PepT1 via assessment of the pharmacokinetics of cefadroxil - a compound transported by PepT1 - in healthy volunteers...
April 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28432630/the-influence-of-restoration-measures-on-phosphorus-internal-loading-from-the-sediments-of-a-hypereutrophic-lake
#7
Katarzyna Kowalczewska-Madura, Renata Dondajewska, Ryszard Gołdyn, Stanisław Podsiadłowski
Uzarzewskie Lake was a hypereutrophic, dimictic lake characterized by low water transparency, high chlorophyll-a concentration and intense phytoplankton blooms; thus, restoration treatment was started. A chemical treatment, based on phosphorus inactivation with small doses of iron sulphate, was undertaken in 2006-2007. Nitrate-rich groundwater flowing from seepage springs was directed into the lake hypolimnion to increase redox potential since 2008. Phosphorus internal loading was reduced by more than 80% as a result of restoration treatment...
April 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432623/performance-of-cstr-egsb-sbr-system-for-treating-sulfate-rich-cellulosic-ethanol-wastewater-and-microbial-community-analysis
#8
Lili Shan, Zhaohan Zhang, Yanling Yu, John Justo Ambuchi, Yujie Feng
Performance and microbial community composition were evaluated in a two-phase anaerobic and aerobic system treating sulfate-rich cellulosic ethanol wastewater (CEW). The system was operated at five different chemical oxygen demand (COD)/SO4(2-) ratios (63.8, 26.3, 17.8, 13.7, and 10.7). Stable performance was obtained for total COD removal efficiency (94.5%), sulfate removal (89.3%), and methane production rate (11.5 L/day) at an organic loading rate of 32.4 kg COD/(m(3)·day). The acidogenic reactor made a positive contribution to net VFAs production (2318...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432612/evaluation-of-the-analgesia-nociception-index-ani-in-healthy-awake-volunteers
#9
Rami Issa, Marco Julien, Elizabeth Décary, Olivier Verdonck, Louis-Philippe Fortier, Pierre Drolet, Philippe Richebé
BACKGROUND: Analgesia might be evaluated with simple changes in vital signs, a non-specific and non-sensitive method. Heart rate variability (HRV) correlates with autonomous nervous system activity and can be used to evaluate painful stimuli. Heart rate variability is then transformed into a numeric scale called the analgesia nociception index (ANI), where higher values represent predominant parasympathetic tone, thus low nociception. Under general anesthesia, the ANI decreases following painful stimuli and increases after administration of analgesia, but significant interindividual variability is present...
April 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28432552/subchronic-nandrolone-administration-reduces-cardiac-oxidative-markers-during-restraint-stress-by-modulating-protein-expression-patterns
#10
Barbara Pergolizzi, Vitina Carriero, Giuliana Abbadessa, Claudia Penna, Paola Berchialla, Silvia De Francia, Enrico Bracco, Silvia Racca
Nandrolone decanoate (ND), an anabolic-androgenic steroid prohibited in collegiate and professional sports, is associated with detrimental cardiovascular effects through redox-dependent mechanisms. We previously observed that high-dose short-term ND administration (15 mg/kg for 2 weeks) did not induce left heart ventricular hypertrophy and, paradoxically, improved postischemic response, whereas chronic ND treatment (5 mg/kg twice a week for 10 weeks) significantly reduced the cardioprotective effect of postconditioning, with an increase in infarct size and a decrease in cardiac performance...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28432493/effect-of-pharmacological-modulation-of-activity-of-metabotropic-glutamate-receptors-on-their-gene-expression-after-excitotoxic-damage-in-hippocampal-neurons
#11
E V Pershina, M V Kapralova, V I Arkhipov
Microinjection of kainic acid into rat hippocampus causes excitotoxic neuronal damage predominantly in the CA3 and CA1 fields. These lesions can be significantly reduced by simultaneous administration of MPEP, a negative allosteric modulator of type 5 metabotropic glutamate receptors, and LY354740, an agonist of type 2 metabotropic glutamate receptors. The decrease in neuronal death in the hippocampus during pharmacological modulation was paralleled by adaptive changes in gene expression. In the hippocampus, gene expression of type 5 postsynaptic metabotropic glutamate receptor was close to the control level, and in the frontal cortex expression of the gene of α1-subunit of the GABAA receptor returned to normal...
April 22, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#12
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
April 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28432433/glypican-3-mrna-expression-level-in-wilms-tumor-correlation-with-histological-type-stage-and-outcome
#13
Md Nahidul Wari, Archana George Vallonthaiel, Aijaz Ahmed, Deepali Saxena, Venkateswaran K Iyer, Sandeep R Mathur, Sandeep Agarwala, Sameer Bakhshi, V Srinivas, P Chattopadhyaya, Arundhati Sharma, S Datta Gupta, Amit Dinda
PURPOSE: To correlate expression of Glypican-3 in Wilms tumor with histopathology, stage, and outcome. METHODS: Glypican-3 mRNA expression by real-time PCR on tumor and normal germline samples from 75 fresh nephrectomies for Wilms tumor with fold change after normalization against GAPDH was compared. Survival analysis for event-free and overall survival (EFS, OS) with 2-year follow-up for Glypican-3 overexpression (>1.5 times) and clinicopathological parameters was performed...
April 21, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28432412/genotyping-by-sequencing-targeting-of-a-novel-downy-mildew-resistance-gene-pl-20-from-wild-helianthus-argophyllus-for-sunflower-helianthus-annuus-l
#14
G J Ma, S G Markell, Q J Song, L L Qi
Genotyping-by-sequencing revealed a new downy mildew resistance gene, Pl 20 , from wild Helianthus argophyllus located on linkage group 8 of the sunflower genome and closely linked to SNP markers that facilitate the marker-assisted selection of resistance genes. Downy mildew (DM), caused by Plasmopara halstedii, is one of the most devastating and yield-limiting diseases of sunflower. Downy mildew resistance identified in wild Helianthus argophyllus accession PI 494578 was determined to be effective against the predominant and virulent races of P...
April 21, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28432407/the-arterial-supply-of-the-nipple-areola-complex-nac-and-its-relations-an-analysis-of-angiographic-ct-imaging-for-breast-pedicle-design
#15
Aaron D Stirling, Conor P Murray, Mark A Lee
PURPOSE: To investigate the blood supply to the nipple areola complex (NAC) on thoracic CT angiograms (CTA) to improve breast pedicle design in reduction mammoplasty. METHODS: In a single centre, CT scans of the thorax were retrospectively reviewed for suitability by a cardiothoracic radiologist. Suitable scans had one or both breasts visible in extended fields, with contrast enhancement of breast vasculature in a female patient. The arterial sources, intercostal space perforated, glandular/subcutaneous course, vessel entry point, and the presence of periareolar anastomoses were recorded for the NAC of each breast...
April 21, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28432379/high-resolution-tomography-based-quantification-of-cortical-porosity-and-cortical-thickness-at-the-surgical-neck-of-the-humerus-during-aging
#16
Tobias Helfen, Christoph M Sprecher, Ursula Eberli, Boyko Gueorguiev, Peter E Müller, Robert G Richards, Florian Schmidutz
Fractures of the proximal humerus are highly related to age and osteoporotic bone remodeling. Previous studies have highlighted the cortex as a major side of the bone loss, but the microstructural changes of the humerus have not been evaluated entirely. Sixty-four (n = 64) humeri of a representative collective (18-100 years) were scanned with high-resolution peripheral quantitative computed tomography (82 µm). Bone mineral density (BMD), trabecular bone volume fraction (Tb.BV/TV), cortical thickness (Ct...
April 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28432338/crispr-cas9-mediated-inactivation-of-argonaute-2-reveals-its-differential-involvement-in-antiviral-responses
#17
Márta Ludman, József Burgyán, Károly Fátyol
RNA silencing constitutes an important antiviral mechanism in plants. Small RNA guided Argonaute proteins fulfill essential role in this process by acting as executors of viral restriction. Plants encode multiple Argonaute proteins of which several exhibit antiviral activities. A recent addition to this group is AGO2. Its involvement in antiviral responses is established predominantly by studies employing mutants of Arabidopsis thaliana. In the virological model plant, Nicotiana benthamiana, the contribution of AGO2 to antiviral immunity is much less certain due to the lack of appropriate genetic mutants...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432299/tangluoning-a-traditional-chinese-medicine-attenuates-in-vivo-and-in-vitro-diabetic-peripheral-neuropathy-through-modulation-of-perk-nrf2-pathway
#18
Xinwei Yang, Weijie Yao, Haolong Liu, Yanbin Gao, Renhui Liu, Liping Xu
Prolonged hyperglycemia-induced oxidative stress and endoplasmic reticulum stress have been demonstrated to play a key role in progression of diabetic peripheral neuropathy (DPN). PERK/ Nrf2 pathway plays a predominant role in oxidative and endoplasmic reticulum (ER) stress which is associated with cell survival. This study examined the modulation of the PERK/Nrf2 pathway and apoptosis by a traditional Chinese medicine Tangluoning (TLN) in streptozotocin-induced DPN rat models and the effects of serum TLN on the PERK/Nrf2 pathway, apoptosis, intracellular reactive oxygen species and mitochondrial membrane potential in Schwann cells cultured in 150 mM glucose...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432210/a-randomised-controlled-trial-of-a-complex-intervention-to-reduce-children-s-exposure-to-secondhand-smoke-in-the-home
#19
Elena Ratschen, Rebecca Thorley, Laura Jones, Magdalena Opazo Breton, Juliette Cook, Ann McNeill, John Britton, Tim Coleman, Sarah Lewis
OBJECTIVES: Exposing children to secondhand tobacco smoke (SHS) causes significant harm and occurs predominantly through smoking by caregivers in the family home. We report a trial of a complex intervention designed to reduce secondhand smoke exposure of children whose primary caregiver feels unable or unwilling to quit smoking. DESIGN: An open-label, parallel, randomised controlled trial. SETTING: Deprived communities in Nottingham City and County, England PARTICIPANTS: Caregivers resident in Nottingham City and County in England who were at least 18 years old, the main caregiver of a child aged under 5 years living in their household, and reported that they were smoking tobacco inside their home...
April 21, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28432149/cd73-on-t-cells-orchestrates-cardiac-wound-healing-after-myocardial-infarction-by-purinergic-metabolic-reprogramming
#20
Nadine Borg, Christina Alter, Nicole Görldt, Christoph Jacoby, Zhaoping Ding, Bodo Steckel, Christine Quast, Florian Bönner, Daniela Friebe, Sebastian Temme, Ulrich Flögel, Jürgen Schrader
Background -T-cells are required for proper healing after myocardial infarction. The mechanism of their beneficial action, however, is unknown. The pro-inflammatory "danger signal" adenosine triphosphate (ATP), released from damaged cells, is degraded by the ectonucleotidases CD39 and CD73 to the anti-inflammatory mediator adenosine. Here, we investigate the contribution of CD73-derived adenosine produced by T-cells to cardiac remodeling after ischemia/reperfusion and define its mechanism of action. Methods -Myocardial ischemia (50 min /reperfusion) was induced in global CD73(-/-) and CD4-CD73(-/-) mice...
April 21, 2017: Circulation
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