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https://www.readbyqxmd.com/read/29782967/deficient-mitochondrial-biogenesis-in-il-2-activated-nk-cells-correlates-with-impaired-pgc1-%C3%AE-upregulation-in-elderly-humans
#1
Dante Miranda, Claudia Jara, Sophia Mejias, Viviana Ahumada, Marcelo Cortez-San Martin, Jorge Ibañez, Sandra Hirsch, Margarita Montoya
Immunosenescence has been described as age-associated changes in the immune function which are thought to be responsible for the increased morbidity with age. Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in immune defense against tumor and microbial diseases. Interestingly, aging-related NK cell dysfunction is associated with features of aging such as tumor incidence, reduced vaccination efficacy, and short survival due to infection. It is known that NK cell effector functions are critically dependent on cytokines and metabolic activity...
May 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29782839/different-regulation-of-cortisol-and-corticosterone-in-the-subterranean-rodent-ctenomys-talarum-responses-to-dexamethasone-angiotensin-ii-potassium-and-diet
#2
Federico Vera, C Daniel Antenucci, Roxana R Zenuto
When harmful environmental stimuli occur, glucocorticoids (GCs), cortisol and corticosterone are currently used to evaluate stress status in vertebrates, since their secretions are primarily associated to an increased activity of the hypothalamic-pituitary-adrenal (HPA) axis. To advance in our comprehension about GCs regulation, we evaluated the subterranean rodent Ctenomys talarum to assess cortisol and corticosterone response to (1) the negative feedback of the HPA axis using the dexamethasone (DEX) suppression test, (2) angiotensin II (Ang II), (3) potassium (K+ ) intake, and (4) different diets (vegetables, grasses, acute fasting)...
May 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29782465/gamma-delta-t-lymphocytes-in-the-diagnostic-approach-of-coeliac-disease
#3
Petula Nijeboer, Tom van Gils, Martine Reijm, Rogier Ooijevaar, Birgit I Lissenberg-Witte, Hetty J Bontkes, Chris J J Mulder, Gerd Bouma
GOALS: To validate cut-off values of CD3 T-cell receptor gamma-delta chain (TCRγδ) intraepithelial lymphocyte (IEL) in the (differential) diagnosis of celiac disease (CD). BACKGROUND: CD is characterized by an increase in gamma-delta IEL (CD3TCRγδ IEL). STUDY: Percentages were determined by flow cytometric analysis of IELs from small bowel biopsies in 213 CD and 13 potential CD (PCD) patients and in total 112 controls. A cut-off value for percentages of CD3TCRγδ IEL to differentiate active CD and controls was obtained from a receiver operating characteristic curve and implemented in controls and PCD patients...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782381/high-baseline-neutrophil-to-lymphocyte-ratio-predicts-worse-outcome-in-patients-with-metastatic-braf-positive-melanoma-treated-with-braf-and-mek-inhibitors
#4
Paweł Teterycz, Paulina Jagodzińska-Mucha, Bożena Cybulska-Stopa, Anna Mariuk-Jarema, Katarzyna Kozak, Hanna Koseła-Paterczyk, Anna M Czarnecka, Marcin Rajczykowski, Robert Dziura, Łukasz Galus, Jacek Mackiewicz, Tomasz Świtaj, Anna Klimczak, Slawomir Falkowski, Rafał Suwiński, Marek Ziobro, Iwona Ługowska, Piotr Rutkowski
Neutrophil-to-lymphocyte ratio (NLR) has been shown to be prognostic in several solid malignancies. There are limited data regarding its value during novel therapies in patients with melanoma. The aim of the study was to assess the practical utility of this ratio in patients with BRAF-mutant melanoma treated with a combination of BRAF and MEK inhibitors (BRAFi/MEKi). We included 215 patients with inoperable or metastatic melanoma who underwent BRAFi/MEKi treatment between October 2015 and June 2017. Baseline NLR and other complete blood count-derived inflammatory markers were tested for association with overall survival and progression-free survival in univariate and multivariate models...
May 18, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29781540/clinical-significance-of-platelet-to-lymphocyte-ratio-in-women-with-preeclampsia
#5
Min-A Kim, Gwan Hee Han, Ja-Young Kwon, Young-Han Kim
PROBLEM: Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE. METHOD OF STUDY: A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study...
May 21, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29781323/targeting-the-b-cell-receptor-pathway-a-review-of-current-and-future-therapies-for-non-hodgkin-s-lymphoma
#6
Thomas D Rodgers, Patrick M Reagan
The B-cell receptor (BCR) pathway is a crucial aspect of mature lymphocytes and is maintained in B-cell neoplasms. Many small module inhibitors targeting kinases within the BCR pathway are approved, with others in development, offering alternative treatment options to standard chemoimmunotherapy. Areas Covered: This review covers both approved inhibitors and investigational inhibitors of spleen tyrosine kinase (SYK), Bruton's tyrosine kinase (BTK), and phosphoinositide-3-kinase (PI3K) in the treatment of B-cell lymphomas...
May 20, 2018: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/29781285/response-to-the-letter-to-the-editor-the-relationship-between-neutrophil-lymphocyte-ratio-and-in-stent-restenosis
#7
Zhihui Chang, Jiahe Zheng, Zhaoyu Liu, Qiyong Guo
No abstract text is available yet for this article.
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29781265/lymphocytic-variant-of-hypereosinophilic-syndrome-presenting-with-polymorphic-cutaneous-manifestations-and-nonspecific-histopathological-findings
#8
Marco Cusini, Alessio Pizzati, Giovanni Genovese, Simona Muratori, Giuseppina Schinco, Emilio Berti
No abstract text is available yet for this article.
May 16, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29781194/paraneoplastic-autoimmune-encephalitis-associated-with-pleomorphic-lung-carcinoma-an-autopsy-case-report
#9
Takashi Ando, Yoji Goto, Kazuo Mano, Fumio Nomura, Masako Kurashige, Masafumi Ito, Maya Mimuro, Yasushi Iwasaki, Masahisa Katsuno, Mari Yoshida
A 64-year-old man was admitted with acute onset disturbed consciousness. Cerebrospinal fluid analysis revealed pleocytosis and elevated protein, with negative cultures and PCR. Serum antibodies for autoimmune encephalitis were also negative. Brain magnetic resonance imaging (MRI) was unremarkable, but whole-body CT scan showed a tumor in the left lower lung lobe. Bronchial brush cytology demonstrated clusters of malignant cells, and 18 F-fluorodeoxyglucose positron emission tomography showed multiple lesions and increased uptake in the lung tumor...
May 20, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29781039/sex-dependent-association-of-circulating-sex-steroids-and-pituitary-hormones-with-treatment-free-survival-in-chronic-lymphocytic-leukemia-patients
#10
Eric P Allain, Karin Venzl, Patrick Caron, Véronique Turcotte, David Simonyan, Michaela Gruber, Trang Le, Eric Lévesque, Chantal Guillemette, Katrina Vanura
Chronic lymphocytic leukemia (CLL) is not considered a hormone-regulated cancer although sex is a recognized risk factor with men more frequently diagnosed and developing progressive disease. We hypothesized that variable hormonal exposure may have a sexually dimorphic influence on treatment-free survival (TFS). In 156 CLL cases, we quantitatively profiled 29 circulating steroids (progesterone, adrenal precursors, androgens, estrogens, and catechol estrogens) as well as luteinizing hormone (LH) and follicle-stimulating hormone...
May 21, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29780793/an-exponential-regression-model-reveals-the-continuous-development-of-b-cell-subpopulations-used-as-reference-values-in-children
#11
Christoph Königs, Stephan Schultze-Strasser, Andrea Quaiser, Konrad Bochennek, Dirk Schwabe, Thomas E Klingebiel, Ulrike Koehl, Claudia Cappel, Udo Rolle, Peter Bader, Melanie Bremm, Sabine Huenecke, Shahrzad Bakhtiar
B lymphocytes are key players in humoral immunity, expressing diverse surface immunoglobulin receptors directed against specific antigenic epitopes. The development and profile of distinct subpopulations have gained awareness in the setting of primary immunodeficiency disorders, primary or secondary autoimmunity and as therapeutic targets of specific antibodies in various diseases. The major B cell subpopulations in peripheral blood include naïve (CD19+ or CD20+ IgD+ CD27- ), non-switched memory (CD19+ or CD20+ IgD+ CD27+ ) and switched memory B cells (CD19+ or CD20+ IgD- CD27+ )...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29780782/combination-of-clinical-and-laboratory-characteristics-may-serve-as-a-potential-diagnostic-marker-for-torsion-on-mature-cystic-teratomas
#12
Ji Yun Lee, Whan Shin, Jeong Sook Kim, Joo Hyun Park, SiHyun Cho
Objective: The objective of this study was to evaluate clinical and laboratory characteristics of torsion on mature cystic teratomas (MCTs). In addition, we examined whether these factors could be helpful in diagnosing MCT torsion. Methods: A retrospective medical record review was conducted for 384 patients who had undergone surgery and histologically verified ovarian MCTs at single university hospital between July 2006 and May 2017. Patients with or without torsion groups were compared with respect to clinical presentation, laboratory findings and surgical course...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780424/reduced-haematopoietic-output-in-automobile-mechanics-and-sprayers-with-chronic-exposure-to-petrochemicals-a-case-control-study-in-cape-coast-ghana
#13
Patrick Adu, Richard Pobee, Aaron Awuah, Paul B Asiamah, Festus Amoani, Sampson Gyabaa
Background: Automobile mechanics and sprayers are at a higher risk of exposure to hazardous chemicals such as polycyclic aromatic hydrocarbons and heavy metals which may cause adverse health outcomes. This study aimed to use reticulocyte count as an indirect measure of the haematological output in automobile mechanics and sprayers in the Cape Coast Metropolis, Ghana. Method: This cross-sectional study recruited 130 participants: 90 cases (57 automobile mechanics and 33 automobile sprayers) and 40 controls (nonautomobile workers)...
2018: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/29780388/regulation-of-hematopoietic-cell-development-and-function-through-phosphoinositides
#14
REVIEW
Mila Elich, Karsten Sauer
One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3 ) by class I phosphoinositide 3 kinases (PI3K). Defective PIP3 signaling impairs almost every aspect of hematopoiesis, including T cell development and function. Limiting PIP3 signaling is particularly important, because excessive PIP3 function in lymphocytes can transform them and cause blood cancers. Here, we review the key functions of PIP3 and related phosphoinositides in hematopoietic cells, with a special focus on those mechanisms dampening PIP3 production, turnover, or function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29780159/modulation-of-store-operated-calcium-entry-and-nascent-adhesion-by-p21-activated-kinase-1
#15
In-Sook Jeon, Hye-Ryun Kim, Eun-Young Shin, Eung-Gook Kim, Heon-Seok Han, Jin-Tae Hong, Hak-Kyo Lee, Ki-Duk Song, Joong-Kook Choi
Calcium mobilization is necessary for cell movement during embryonic development, lymphocyte synapse formation, wound healing, and cancer cell metastasis. Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE)...
May 21, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29780108/plasmacytoid-lymphocytes-a-diagnostic-clue-for-dengue-fever
#16
Yasuhiro Tanaka
No abstract text is available yet for this article.
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779969/increased-malondialdehyde-vs-reduced-sirtuin-1-in-relation-with-adiposity-atherogenicity-and-hematological-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#17
Samar Abu Rkhaya, Nailya Bulatova, Violet Kasabri, Randa Naffa, Reema Alquoqa
BACKGROUND: Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. AIMS AND METHODS: This cross-sectional study aimed to investigate both SIRT 1 and MDA in 30 lean healthy control, 31 normoglycemic MetS subjects and 30 MetS-Pre/T2DM drug naïve. C orrelation studies were established for both biomarkers with adiposity indices [conicity index (CI), waist circumference (WC), weight-to-height (WHtR) ratio, weight-to-hip (WHR) ratio, hip circumference (HC), and body adiposity index (BAI)], hematological indices [red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphcyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR)] and atherogenicity indices (atherogenicity index of plasma (AIP = log10 TG/HDL-C ratio), TC/HDL-C and LDL-C/HDL-C ratios]...
May 15, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29779813/negative-role-of-malnutrition-in-cell-mediated-immune-response-pneumocystis-jirovecii-pneumonia-pcp-in-a-severely-malnourished-hiv-negative-patient-with-anorexia-nervosa
#18
Mouna Hanachi, Vanessa Bohem, Pauline Bemer, Nadja Kayser, Pierre de Truchis, Jean-Claude Melchior
It is generally acknowledged that malnutrition is a propensity factor for secondary infections in different clinical situations (malnutrition-associated infections in hospitalized patients and malnourished children in developing countries). However, it is not clear how malnutrition might facilitate the development of opportunistic infections in human immunodeficiency virus (HIV)-negative patients without a definite etiology (disease or treatment) of impaired cell-mediated immune response. We report here on a case of Pneumocystis jirovecii pneumonia in an HIV-negative patient suffering from anorexia nervosa with extreme malnutrition, which had a favorable outcome despite the severity of her respiratory failure...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29779804/the-importance-of-serum-albumin-determination-method-to-classify-patients-based-on-nutritional-status
#19
M Duque Alcorta, P Chanca Alvarez, R Nuñez Cabetas, Mj Alcaide Martín, M Valero, C Gómez Candela
The global health community has recognized the role of food and nutrition in health maintenance and disease prevention. Undernutrition is an important problem in clinical circles but it is still not highly considered by specialists. It is well known the consequences of undernutrition on the immunological systems. Furthermore, the main consequences are an increase of morbidity-mortality rates, postoperative complications, length of stay and number of hospital early readmissions. These are all reasons to lead to increase health-care financial costs...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29779777/interleukin-23-interleukin-17-axis-activated-by-mycobacterium-avium-complex-mac-is-attenuated-in-patients-with-mac-lung-disease
#20
Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Hsin-Chih Lai, Bor-Luen Chiang, Chong-Jen Yu
BACKGROUND: Mycobacterium avium complex (MAC)-lung disease (LD) is increasing in patients without human immunodeficiency virus infection. However, data on host vulnerability to MAC-related immune responses, and in particular the interleukin (IL)-23/IL-17 axis, are lacking. METHODS: We enrolled 50 patients with MAC-LD, 25 age-matched patients with tuberculosis (TB) and 25 controls. We measured levels of plasma cytokines, and studied IL-12/IL-17 responses in macrophage and lymphocyte activation to MAC...
May 2018: Tuberculosis
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