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Yurie Shimoda-Komatsu, Misaki Kinoshita-Ise, Hiroaki Shimoyamada, Manabu Ohyama
Granuloma faciale (GF) is a rare chronic dermatosis with still unknown etiopathology, which usually presents a solitary, asymptomatic, smooth reddish-brown to violaceous plaques or nodules on the face. Various therapeutic approaches, including topical application of corticosteroid or tacrolimus and removal with laser, cryotherapy and surgery have been attempted; however, the outcome has been inconsistent. Herein, we report a case of perinasal nodular GF who repeatedly underwent surgical excisions after the failure of laser treatment...
June 15, 2018: Journal of Dermatology
Patricia M de Groot, Girish S Shroff, Judy Ahrar, Bradley S Sabloff, Garret M Gladish, Cesar Moran, Sanjay Gupta, Gregory W Gladish, Joe Y Chang, Jeremy J Erasmus
Purpose: Precision radiation therapy such as stereotactic body radiation therapy and limited resection are being used more frequently to treat intrathoracic malignancies. Effective local control requires precise radiation target delineation or complete resection. Lung biopsy tracts (LBT) on computed tomography (CT) scans after the use of tract sealants can mimic malignant tract seeding (MTS) and it is unclear whether these LBTs should be included in the calculated tumor volume or resected...
April 2018: Advances in Radiation Oncology
Jongmin Sim, Hyun Hee Koh, Sangjoon Choi, Jinah Chu, Tae Sung Kim, Hojoong Kim, Joungho Han
Background: Pulmonary nodular lymphoid hyperplasia (PNLH) is a non-neoplastic pulmonary lymphoid disorder that can be mistaken for malignancy on radiography. Herein, we present nine cases of PNLH, emphasizing clinicoradiological findings and histological features. Materials and Methods: We analyzed radiological and clinicopathological features from the electronic medical records of nine patients (eight females and one male) diagnosed with PNLH. IgG and IgG4 immunohistochemical staining was performed in three patients...
June 15, 2018: Journal of Pathology and Translational Medicine
W Y Ma, W Liu, X Z Li, P Ye, L Q Zhang, X L Cai
Objective: To discuss the application of Mohs microsurgery in nasal and facial basal cell carcinoma (BCC) and analyze the pathological and clinical features. Methods: The clinical data of 127 patients who were diagnosed by pathology as nasal and facial BCC in Qilu Hospital of Shandong University from January 2010 to January 2015 were retrospectively analysed. The value of Mohs microsurgery was discussed and the nasal & facial sites of BCC lesions, clinical and histopathology features were summarized. Results: The proportion of male and female was 1...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
Mengxue Yang, Biao Long, Jie Xu, Jie Yu, Xianwen Li, Fanhao Ye, Bo Yang, Yulan Liao, Sicheng Li, Ya Li, Xue Zhou
Carney complex (CNC) is a rare genetic disease. Here, we report a case of CNC and explore clinical manifestations and gene mutation studies of CNC. A male patient with CNC at the age of 16 yr was admitted to Affiliated Hospital of Zunyi Medical University in July, 2015. Although the patient had typical signs of Cushing's syndrome, he also presented with certain rare signs of Cushing's syndrome, such as "freckle-like" scattered spots of pigmentation on the face and around the lips. In addition, concomitant severe osteoporosis led to flattened vertebrae and the compression of corresponding levels of the spinal cord...
April 2018: Iranian Journal of Public Health
Monira Haque, Nadia Hameed, Christopher T Perry, Elliot Carter, Wadad S Mneimneh
We report a case of malignant peritoneal mesothelioma (MPM) in a 31-year-old male with history of cerebral palsy, hydrocephalus, and ventriculoperitoneal shunt (VPS) placed since infancy. He presented with fever, abdominal pain and distension. Computed tomography scan revealed a thick-walled rim-enhancing fluid collection, interpreted as pseudocyst. Intraoperatively, diffuse nodular peritoneal thickening with adhesions was demonstrated. The resection specimen consisted of multiple membranous fragments displaying firm nodules...
2018: Clinical Medicine Insights. Oncology
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Diagnostic Cytopathology
Lucélia J Pinheiro, Larissa F Paranaíba, Adriano F Alves, Patrícia M Parreiras, Nelder F Gontijo, Rodrigo P Soares, Wagner L Tafuri
The subgenus Mundinia includes several Leishmania species that have human and veterinary importance. One of those members, Leishmania Mundinia enriettii was isolated from the guinea pig Cavia porcellus in the 1940s. Several histopathological studies have already been performed in this species in the absence of salivary gland extract (SGE), which are determinant and the early and future events of the infection. Our main hypothesis is that SGE could differentially modulate the course of the lesion and macrophage differentiation caused by avirulent and virulent L...
2018: Frontiers in Microbiology
Michael Ryan, Hamad Alabdulrazzaq, Jennifer Toyohara
Perianal basal cell carcinoma (BCC) is a rare lesion that accounts for less than 0.08% of all BCCs. It is challenging to diagnose, as it can be overlooked or mistaken for an inflammatory dermatosis. When discovered early and treated properly, BCC is associated with low mortality and a good prognosis. Thorough total-body skin examinations and biopsy of suspected lesions found in the perianal region is recommended. We present a case of a superficial nodular perianal BCC that was discovered following a routine total-body skin examination and was treated with Mohs micrographic surgery (MMS)...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
Maya Prasad, Gaurav Narula, Girish Chinnaswamy, Brijesh Arora, Tanuja Shet, Poonam Panjwani, Manju Sengar, Siddharth Laskar, Nehal Khanna, Shripad Banavali
BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma (HL) with few published studies in children, entirely from North America and Europe. We analyzed clinical features and treatment outcome of pediatric NLPHL. PROCEDURE: Children less than 18 years of age diagnosed after histopathology review to have NLPHL between June 1998 and August 2016 were retrospectively analyzed. Descriptive details of clinical presentation and treatment were collected, and outcomes analyzed using Kaplan-Meier survival analysis...
June 12, 2018: Pediatric Blood & Cancer
Preithy Uthamalingam, Ashim Das, Arunanshu Behra, Naveen Kalra, Yogesh Chawla
Background and objectives: Histopathological distinction of various nodular lesions in liver with sufficient sensitivity and specificity is a challenge even in an expert set up. The panel of immunohistochemical markers composed of glutamine synthetase (GS), Glypican3 (GPC3) and heat shock protein 70 (HSP70) was recommended by the International Consensus Group for Hepatocellular Neoplasia group for the differentiation of high grade dysplastic nodule and early hepatocellular carcinoma (HCC)...
June 2018: Journal of Clinical and Experimental Hepatology
Hossein Mortazavi, Leila Izadi Firouzabadi, Alireza Ghanadan, Hassan Seirafi, Seyed Naser Emadi, Safoura Shakoei
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran-Iraq war. He developed skin lesions 3 years after exposure to sulfur mustard gas at the age of 21. Seven years after his exposure to sulfur mustard gas, a biopsy from the posterior distal part of his calf, which was injured and had bulla, revealed MF...
May 2018: Iranian Journal of Medical Sciences
N J Collier, A K Haylett, T H Wong, C A Morton, S H Ibbotson, K E McKenna, R Mallipeddi, H Moseley, D Seukeran, K A Ward, M F Mohd Mustapa, L S Exton, A C Green, L E Rhodes
BACKGROUND: Topical photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). OBJECTIVES: Compare efficacy, cosmesis and tolerability of PDT for BCC with alternative treatments. METHODS: MEDLINE/PubMed/EMBASE/CENTRAL databases were searched from inception until 1 September 2017. Included studies were randomised controlled trials (RCTs) of PDT for nodular (n) and superficial (s) BCC reporting at least one of the outcomes: clearance at 3 months, and sustained at 1 or 5 years; recurrence at ≥1 year; cosmesis; adverse events; tolerability...
June 11, 2018: British Journal of Dermatology
Ying Lu, Baoxian Liu, Yanling Zheng, Jia Luo, Xiaoer Zhang, Guangliang Huang, Xiaohua Xie, Jieyi Ye, Wei Wang, Xusheng Liu, Xiaoyan Xie
Focal liver lesions (FLLs) include a variety of benign and malignant tumors, and are usually differential diagnosed by ultrasonography. However, traditional two-dimensional contrast-enhanced ultrasound (2D-CEUS) can evaluate a single slice of a lesion. It cannot fully display perfusion of a lesion and the relationship with the surrounding tissues, which may lead to misdiagnosis. This study aimed to investigate real-time three-dimensional CEUS (3D-CEUS) for evaluation of the vascular configuration of FLLs. Using real-time 3D-CEUS with SonoVue on 161 patients with FLLs, we found that when compared with 2D-CEUS, real-time 3D-CEUS provided more detailed information about the origin, continuity, and numbers and structures of the feeding artery...
2018: American Journal of Translational Research
Shahnawaz Rajpar, Bilal Surya, Khalil Mobin, Santosh Kumar
To share the experience of 100 cases of Transurethral Resection of Prostate (TURP), This cross-sectional study was conducted in the Department of Urology, SMBBMC and Lyari General Hospital, Karachi from 1.1.13 to 30.4.15. One hundred cases were selected through purposive sampling. Patients who underwent TURP were included. Those with two life threatening co-morbidities, positive urine culture and patients on anti coagulant medications were excluded from the study. Mean age of the patients was 66±6.2 years with minimum 60 years and maximum 85 years...
May 2018: JPMA. the Journal of the Pakistan Medical Association
Edward T H Fysh, Rajesh Thomas, Claire Tobin, Yi Jin Kuok, Y C Gary Lee
Detection of pleural abnormalities on CT scan is critical in diagnosis of pleural disease. CT scan detects minute parenchymal lung nodules, but often fails to detect similar-sized pleural nodularity. This is likely because the density of the visceral/parietal pleura and pleural fluid is similar. We hypothesize that an air-pleural interface enhances detection of pleural abnormalities. We describe six patients with pleural abnormalities that were not (or barely) detected on initial CT scan. However, pneumothorax (either ex vacuo or from a genuine air leak) after pleural fluid drainage permitted the visualization of small pleural abnormalities on CT scan, which would be amenable to imaging-guided biopsies...
June 2018: Chest
Emine Müge Acar, Murat Tad, Asuman Kilitci, Funda Kemeriz
We report a case of hemosiderotic dermatofibroma presenting as a brown-black-colored nodule with peripheral extensions, which mimics melanoma. Histopathology showed completely benign features with no atypia or mitosis. Nodular extensions of childhood dermatofibromas may be related to the growth of the child not necessarily pointing to a malignant process.
June 2018: Clinical Case Reports
Kwame Doh, Ibou Thiam, Romulus Carmen Adechina Takin, Khaled Sonhaye, Gisèle Woto-Gaye
INTRODUCTION: Sebaceous lymphadenoma of the parotid (SLP) is a rare, benign tumor with similar epidemiological and macroscopic characteristics with other sebaceous differentiated tumors of the parotid (SDTP). The authors report a case of SLP in an 80-year-old woman. They then recall the distinctive histological and immunohistochemical criteria of SDTP. OBSERVATION: Mrs P. D. was received during a surgical consultation for the management of a painless right parotid swelling that has evolved for 10years, increasing slightly in volume...
June 4, 2018: Annales de Pathologie
Christina A Arnold, Wendy L Frankel, Ling Guo, Chandra Krishnan, Sheryl Pfeil, Melinda Schumacher, Lysandra Voltaggio, Martha M Yearsley, Wei Chen
Crystal-storing histiocytosis (CSH) is an under-recognized entity with a striking association with lymphoproliferative disorders. To study the typical morphologic features of gastric CSH, all lymphomas diagnosed on in-house gastric specimens at The Ohio State University between January 1, 2008 and January 1, 2017 were retrieved. This search yielded 66 specimens from 51 unique patients. All cases were reviewed with CSH identified in 7 stomach biopsies from 4 patients (2 men:2 women; average age, 69 y; range, 56 to 82 y)...
June 6, 2018: American Journal of Surgical Pathology
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