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https://www.readbyqxmd.com/read/29683819/primary-and-metastatic-melanoma-with-ntrk-fusions
#1
Cecilia Lezcano, Alexander N Shoushtari, Charlotte Ariyan, Travis J Hollmann, Klaus J Busam
A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions. Various translocations, such as those involving the anaplastic lymphoma kinase (ALK), neurotrophic tropomyosin receptor kinase 1 (NTRK1), and NTRK3 have been reported in spitzoid melanocytic neoplasms leading to kinase-fusion proteins that result in immunohistochemically detectable ALK or NTRK expression...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683432/granular-cell-tumour-of-the-tongue-treated-by-radiofrequency-ablation
#2
Saverio Capodiferro, Angela Tempesta, Luisa Limongelli, Eugenio Maiorano, Gianfranco Favia
AIM: To report on a case of granular cell tumour occurring in the tongue surgically removed by surgical radiofrequency, with histological examination. MATERIAL OF STUDY: Discussion on the clinico-pathological characteristics of the granular cell tumour and the surgical treatment by surgical radiofrequency: the differential diagnosis is also discussed. RESULTS: Histological examination is mandatory for the final diagnosis. Surgical radiofrequency is an useful medical device to achieve good quality surgery with minimal post-operative course...
April 23, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29681220/reactive-nodular-fibrous-pseudotumor-mimicking-metastatic-gastrointestinal-stromal-tumor-to-perigastric-lymph-node-a-case-report-and-review-of-the-literature
#3
Jinesa Moodley, Jean-Claude Cutz, Miranda Schell
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 years postsurgical treatment for biopsy-proven GIST, clinically suspicious for a recurrent/metastatic GIST. The patient had also received adjuvant tyrosine kinase inhibitor therapy. Microscopic sections from the perigastric lesion showed a spindle cell nodule felt initially to represent a GIST with posttherapeutic changes...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29676525/leonine-facies-presenting-as-scleromyxedema
#4
Annie Y Park, Lori Lowe, Dinesh Khanna
A 61-year-old man previously in good health was referred to Scleroderma Clinic for a 2-year history of slowly progressive cutaneous eruption involving his dorsal hands, extremities, and central face. On physical examination, the patient had nodular, erythematous indurated lesions of his forehead and erythematous papular lesions on his nose with coalescence of firm erythematous papulonodules, resulting in a leonine facies. On the dorsal hands, arms, and legs were numerous, shiny, firm, closely set, 1-2 mm slightly translucent papules with background erythema (face and hand, shown in Panel A)...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29676376/an-unusual-presentation-of-large-b-cell-lymphoma-with-interferon-regulatory-factor-4-gene-rearrangement
#5
Anuj Verma, Sridhar Epari, Sumeet Gujral, Tanuja Shet
Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675756/nodular-macroregenerative-tissue-as-a-pattern-of-regeneration-in-cholangiopathic-disorders
#6
Preston Roberts, Andrew T Trout, Jonathan R Dillman
BACKGROUND: Published case series have described central hepatic macroregenerative nodules or masses as a common feature of Alagille syndrome. Our experience suggests this regenerative pattern can be seen more generally in cholangiopathic disorders. OBJECTIVE: To define the frequency of central regenerative tissue in Alagille syndrome and other cholangiopathic disorders and to describe the typical appearance of such regenerative tissue. MATERIALS AND METHODS: We conducted a retrospective study of CT and MR imaging performed in children and young adults with cholangiopathic disorders between January 2000 and June 2016...
April 19, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29675360/deep-infiltrating-endometriosis-mr-imaging-with-surgical-correlation
#7
REVIEW
Xue Tang, Rennan Ling, Jingshan Gong, Dongdong Mei, Yan Luo, Minge Li, Jianmin Xu, Liguo Ma
In this pictorial review, MR imaging findings of deep infiltrating endometriosis (DIE) are illustrated together with surgical correlation. DIE can appear as irregular nodules or plaques with similar signal intensity to muscle on both T1-weighted and T2-weighted images. Hemorrhage foci and strands or stellate margins are also often noted. Restriction of diffusion can be seen on diffusion-weighted image. Fibrosis and adhesions often result in morphologic changes, such as alimentary tract tortuosity, irregular or nodular thickening of uterosacral ligaments, and partial or complete obliteration of the pouch of Douglas...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29675357/radiological-signs-associated-with-pulmonary-multi-drug-resistant-tuberculosis-an-analysis-of-published-evidences
#8
Yì Xiáng J Wáng, Myung Jin Chung, Aliaksandr Skrahin, Alex Rosenthal, Andrei Gabrielian, Michael Tartakovsky
Background: Despite that confirmative diagnosis of pulmonary drug-sensitive tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) is determined by microbiological testing, early suspicions of MDR-TB by chest imaging are highly desirable in order to guide diagnostic process. We aim to perform an analysis of currently available literatures on radiological signs associated with pulmonary MDR-TB. Methods: A literature search was performed using PubMed on January 29, 2018...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#9
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29673751/-primary-cutaneous-cd30-t-cell-lymphoproliferation-during-treatment-with-fingolimod-case-report-and-literature-review
#10
E Cesbron, J-B Monfort, C Giannesini, P Duriez, P Moguelet, P Senet, C Francès, A Barbaud, F Chasset
BACKGROUND: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. PATIENTS AND METHODS: A 56-year-old woman developed cutaneous indurated and ulcerated nodular lesions 6 months after starting fingolimod for active relapsing-remitting multiple sclerosis...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29671057/accurate-ivim-model-based-liver-lesion-characterisation-can-be-achieved-with-only-three-b-value-dwi
#11
P Mürtz, A M Sprinkart, M Reick, C C Pieper, A-H Schievelkamp, R König, H H Schild, W A Willinek, G M Kukuk
OBJECTIVE: The objective of this study was to evaluate a simplified intravoxel incoherent motion (IVIM) approach of diffusion-weighted imaging (DWI) with four b-values for liver lesion characterisation at 1.5 T. METHODS: DWI data from a respiratory-gated MRI sequence with b = 0, 50, 250, 800 s/mm2 were retrospectively analysed in 173 lesions and 40 healthy livers. The apparent diffusion coefficient ADC = ADC(0,800) and IVIM-based parameters D1 ' = ADC(50,800), D2 ' =ADC(250,800), f1 ', f2 ', D*', ADClow = ADC(0,50), and ADCdiff =ADClow -D2 ' were calculated voxel-wise without fitting procedures...
April 18, 2018: European Radiology
https://www.readbyqxmd.com/read/29669679/calcitonin-screening-in-nodular-goiter-upper-limits
#12
Friedhelm Raue, Karin Frank-Raue
No abstract text is available yet for this article.
March 30, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29669372/-congenital-simple-hamartoma-of-the-retinal-pigment-epithelium
#13
Veit Sturm, Josef Guber, Marcio Silva, Jan Heckmann, Claudia Zawinka
BACKGROUND: Congenital simple hamartoma of the retinal pigment epithelium (CSHRPE) is an uncommon benign lesion with characteristic clinical features. Ophthalmoscopically it appears as a small localized, well circumscribed, pigmented tumor in the foveal region. In contrast to the more common flat congenital hypertrophy of the RPE the CSHRPE has an elevated nodular appearance. PATIENTS AND METHODS: Retrospective case series of three patients with CSHRPE. Clinical morphological features using different imaging techniques are presented...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#14
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29668456/review-on-retinal-gliosis-illustrated-with-a-series-of-massive-glioses-and-focal-nodular-gliosis-cases-in-regard-to-potential-pitfalls-of-ocular-reactive-tumor-like-lesions-of-this-type
#15
REVIEW
Andrzej Wincewicz, Sławka Urbaniak-Wasik, Antoinette Urbaniak, Marlena Mościcka-Rylska, Martyna Woltanowska, Mariusz Koda, Stanislaw Sulkowski, Joanna Reszeć
This paper presents a review on retinal gliosis illustrated by series of three cases of patients (a 39-year-old man and a 35-year-old woman with massive retinal gliosis (MRG) and a 51-year-old man with truly focal nodular gliosis of retina) with intraocular tumor-like masses and loss of vision, who recently suffered from painful inflammation of eyeball and who classically had a history of remote ocular trauma, onset of blindness early in lifetime or gradual but progressive loss of sight. The diagnosis of this pathological entity is given for the lesions that are composed of GFAP strongly positive, elongated, fusiform cells consistent with fibrillary astrocytes...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29665631/primary-colonic-follicular-lymphoma-presenting-as-four-diminutive-sessile-polyps-found-incidentally-during-colonoscopy
#16
Sun Jin, Hyun Seok Lee, Ji Yun Jeong, Young Wook Jo
Follicular lymphomas, which typically arise in the lymph nodes with spleen, liver, and bone marrow involvement, have generally low occurrence rates in Asian countries as compared with Western countries. Follicular lymphomas of the gastrointestinal tract are rare, and primary colonic follicular lymphomas are particularly rare compared with others found in the small intestine and duodenum. Colonoscopic imaging of colonic lymphomas, including follicular lymphoma, may reveal mucosal ulcerations, erosions, indurations, polypoid mass-like lesions, and diffuse mucosal nodularity...
April 18, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29663743/intraspinal-intradural-nodular-fasciitis-mimicking-glioblastoma-metastasis-a-case-report
#17
Carl Moritz Zipser, Lars Füllbier, Rudi Beschorner, Hans Bösmüller, Ulf Ziemann, Marcos Soares Tatagiba, Ghazaleh Tabatabai, Benjamin Bender, Felix Behling
We report the case of a 78-year-old male patient suffering from right temporal glioblastoma with radiographic meningeal tumor spread. During the further course of the disease he developed a rapidly progressive paraplegia. An magnetic resonance imaging scan showed a contrast enhancing an intraspinal intradural lesion with compression of the myelon on segment Th 8/9. With a high suspicion of a spinal metastasis of the known glioblastoma, emergency spinal decompression and resection of the intradural mass was performed...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29663025/imaging-appearance-of-well-differentiated-liposarcomas-with-myxoid-stroma
#18
Yoav Morag, Corrie Yablon, Monica Kalume Brigido, Jon Jacobson, David Lucas
OBJECTIVE: Describe the imaging appearance of well-differentiated liposarcoma with myxoid stroma (WDLMS) and correlate with histopathology. MATERIALS AND METHODS: A keyword search of the institution medical records was performed from 1 January 2000 to 30 June 2017. The histopathology slides of cases identified in this fashion were then reviewed by a pathologist. Additional cases were prospectively collected from extramural referrals and tumor boards. Diagnostic imaging studies of pathologically proven cases of WDLMS were then reviewed in consensus and correlated with pathology...
April 16, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29663010/septo-optic-dysplasia-assessment-of-associated-findings-with-special-attention-to-the-olfactory-sulci-and-tracts
#19
John C Benson, David Nascene, Charles Truwit, Alexander M McKinney
PURPOSE: Septo-optic dysplasia is a congenital disorder consisting of optic nerve hypoplasia and absent septum pellucidum. While associated anomalies have been described, olfactory sulcus and bulb-tract hypoplasia have been scantily reported and was the focus of this study. METHODS: The picture archival and communications system and radiology information system (PACS-RIS) was searched over 15 years for patients with suspected septo-optic dysplasia (n = 41) and cerebral magnetic resonance imaging (MRI)...
April 16, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29662812/pulmonary-nodular-lymphoid-hyperplasia-in-a-33-year-old-woman
#20
Ji Ye Park, Seong Yong Park, Seokjin Haam, Joonho Jung, Young Wha Koh
Pulmonary nodular lymphoid hyperplasia is a reactive lymphoproliferative disease. It is very rare, which means that many aspects of the disease are unknown or have not been proven. Pulmonary nodular lymphoid hyperplasia can be symptomatic or asymptomatic, progressive or not, and solitary or multiple, and a surgical approach is the current treatment of choice. We present a case of pulmonary nodular lymphoid hyperplasia that was visualized as multiple ground glass opacities on a computed tomography (CT) scan, and observed for 1 year because the patient was pregnant...
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
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