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https://www.readbyqxmd.com/read/28090048/hyponatremia-in-an-elderly-patient-due-to-isolated-hypoaldosteronism-occurring-after-licorice-withdrawal
#1
Yuji Hataya, Akifumi Oba, Takafumi Yamashita, Yasato Komatsu
Hyponatremia is one of the most common electrolyte disorders encountered in the elderly. We present the case of an 81-year-old man who developed hyponatremia due to isolated hypoaldosteronism occurring after licorice withdrawal. He had severe hypokalemia with hypertension and was diagnosed with pseudoaldosteronism. He had been taking a very small dose of licorice as a mouth refresher since his early adulthood. Five months after licorice withdrawal, he developed hypovolemic hyponatremia, which was resolved with administration of fludrocortisone acetate...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28087760/molecularly-imprinted-solid-phase-extraction-using-bismethacryloyl-%C3%AE-cyclodextrin-and-methacrylic-acid-as-double-functional-monomers-for-selective-analysis-of-glycyrrhizic-acid-in-aqueous-media
#2
Weili Tang, Wei Du, Pengqi Guo, Ningli Wu, Kangli Du, Changgen Xu, Zhimin Luo, Ruimiao Chang, Aiguo Zeng, Wanghui Jing, Chun Chang, Ji Li, Qiang Fu
In this work, a new molecularly imprinted solid phase extraction protocol was developed for the selective extraction and purification of glycyrrhizic acid from liquorice roots in aqueous media. The molecularly imprinted polymers (MIPs) for glycyrrhizic acid were prepared by using bismethacryloyl-β-cyclodextrin and methacrylic acid as double functional monomers and characterized by Fourier transform infrared spectroscopy, scanning electron microscope, thermo gravimetric analysis, nitrogen adsorption and elemental analysis...
February 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28055288/eveningness-as-a-risk-for-behavioral-problems-in-late-adolescence
#3
Ilona Merikanto, Anu-Katriina Pesonen, Liisa Kuula, Jari Lahti, Kati Heinonen, Eero Kajantie, Katri Räikkönen
Circadian preference toward eveningness has been associated with increased risk for mental health problems both in early adolescence and in adulthood. However, in late adolescence, when circadian rhythm naturally shifts to later, its significance for mental health is not clear. Accordingly, we studied how circadian rhythm estimated both by self-reported chronotype and by actigraph-defined midpoint of sleep was associated with self-reported psychiatric problems based on Youth Self Report (YSR). The study builds on a community cohort born in 1998, Helsinki, Finland...
January 5, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28045565/the-effect-of-licorice-protein-fractions-on-proliferation-and-apoptosis-of-gastrointestinal-cancer-cell-lines
#4
Soheila Khazraei-Moradian, Mazdak Ganjalikhani-Hakemi, Alireza Andalib, Reza Yazdani, Javad Arasteh, Gholam Ali Kardar
BACKGROUND: Several methods for the treatment of colon cancer have been introduced, but none of them are safe and effective. We planned to evaluate the inhibitory effect of protein extract of licorice root on HT-29 and CT26 cell lines proliferation and apoptosis. METHODS: Protein extract of licorice root was prepared in phosphate-buffered solution, and SDS-PAGE was used to isolate its fractions. HT-29, CT-26, and HEK293 cell lines were treated with various concentrations of the fractions and full extract of licorice...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28031830/development-of-diffuse-alveolar-damage-after-initiation-of-nijutsuto
#5
Motoyasu Kato, Shinichi Sasaki, Hiroshi Izumi, Toshimasa Uekusa, Shigeru Tominaga, Kazuhisa Takahashi
Chinese traditional medicine, Nijutsuto, is used to treat patients with frozen shoulder and osteoarthritis. Herbal medicine is often linked to the development of interstitial lung disease. An 83-year-old Japanese man with osteoarthritis who was on Nijutsuto was admitted to our hospital with dyspnoea and severe cough after 2 weeks from initiation of Nijutsuto. A chest computed tomography scan on admission showed diffuse ground glass opacity with traction bronchiectasis. Thus, he was diagnosed with Nijutsuto-induced interstitial lung disease, and was treated with a high dose of methylprednisolone and cyclophosphamide...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28008473/cyp716a179-functions-as-a-triterpene-c-28-oxidase-in-tissue-cultured-stolons-of-glycyrrhiza-uralensis
#6
Keita Tamura, Hikaru Seki, Hideyuki Suzuki, Mareshige Kojoma, Kazuki Saito, Toshiya Muranaka
CYP716A179, a cytochrome P450 monooxygenase expressed predominantly in tissue-cultured stolons of licorice ( Glycyrrhiza uralensis ), functions as a triterpene C-28 oxidase in the biosynthesis of oleanolic acid and betulinic acid. Cytochrome P450 monooxygenases (P450s) play key roles in the structural diversification of plant triterpenoids. Among these, the CYP716A subfamily, which functions mainly as a triterpene C-28 oxidase, is common in plants. Licorice (Glycyrrhiza uralensis) produces bioactive triterpenoids, such as glycyrrhizin and soyasaponins, and relevant P450s (CYP88D6, CYP72A154, and CYP93E3) have been identified; however, no CYP716A subfamily P450 has been isolated...
December 22, 2016: Plant Cell Reports
https://www.readbyqxmd.com/read/27992218/characterization-of-the-key-aroma-compounds-in-heat-processed-licorice-succus-liquiritiae-by-means-of-molecular-sensory-science
#7
Juliane Wagner, Peter Schieberle, Michael Granvogl
Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylfuran-2(5H)-one, 4-hydroxy-3-methoxybenzaldehyde, 3-hydroxy-2-methyl-4H-pyran-4-one, and 2-methoxyphenol (all 1024)...
December 19, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27979300/a-new-exploration-of-licorice-metabolome
#8
Giovanni Rizzato, Elisa Scalabrin, Marta Radaelli, Gabriele Capodaglio, Oreste Piccolo
The roots and rhizomes of licorice plants (genus Glycyrrhiza L.) are commercially employed, after processing, in confectionery production or as sweetening and flavouring agents in the food, tobacco and beer industries. G. glabra, G. inflata and G. uralensis are the most significant licorice species, often indistinctly used for different productions. Licorice properties are directly related to its chemical composition, which determines the commercial values and the quality of the derived products. In order to better understand the characteristics and properties of each species, a chemical characterization of three species of licorice (G...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27975643/microwave-assisted-simultaneous-extraction-of-liquiritigenin-and-glycyrrhizic-acid-from-licorice-glycyrrhizae-radix-et-rhizoma
#9
H K Lim, M E Baek, Y Jo, J H Kwon
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27957263/different-modalities-for-treatment-of-recurrent-aphthous-stomatitis-a-randomized-clinical-trial
#10
Sherine A Nasry, Hanaa M El Shenawy, Dina Mostafa, Nagwa M Ammar
BACKGROUND: The underlying etiology of recurrent aphthous stomatitis (RAS) is unclear and treatment aims to provide symptomatic and faster relief. This study compared the efficacy of diode laser, a herbal combination of Acacia nilotica and Licorice (A and L) and Amlexanox in the management of RAS. MATERIAL AND METHODS: Sixty patients with minor aphthae were selected and randomly divided into four groups of 15 each. Group I and II received adhesive preparations of a herbal mixture of A and L and a 2 mg Amlexanox paste respectively, group III received diode laser and the fourth group (control) used a placebo...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27920817/pharmacological-characterization-of-liquiritigenin-a-chiral-flavonoid-in-licorice
#11
Samaa Alrushaid, Neal M Davies, Stephanie E Martinez, Casey L Sayre
Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. Where possible, the pure enantiomers were tested to identify the stereospecific contribution to the activity. In vitro antioxidant, anticancer, anti-inflammatory activities (cyclooxygenase inhibition), antidiabetic activities (alpha-amylase and alpha-glucosidase inhibition) as well as cytochrome P450 (CYP450) inhibitory activities were assessed...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27907868/purification-of-high-purity-glycyrrhizin-from-licorice-using-hydrophilic-interaction-solid-phase-extraction-coupled-with-preparative-reversed-phase-liquid-chromatography
#12
Wenyi Yu, Hongli Jin, Aijin Shen, Liang Deng, Jianlian Shi, Xingya Xue, Yadong Guo, Yanfang Liu, Xinmiao Liang
Glycyrrhizin (GA), a major bioactive compound in licorice, has been extensively used throughout the world as a medicine to treat chronic viral hepatitis and allergic dermatitis. In this study, a new method based on hydrophilic interaction solid phase extraction (HILIC-SPE) and preparative reversed-phase liquid chromatography (prep-RPLC) was developed to purify GA with high purity from the complex licorice extract. Via evaluation of retention behavior of GA and flavonoids in different commercially available columns, a hydrophilic column--Click XIon was finally chosen for the purification due to its excellent resolution toward GA and flavonoids under HILIC mode...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27904813/glycyrrhetinic-acid-might-increase-the-nephrotoxicity-of-bakuchiol-by-inhibiting-cytochrome-p450-isoenzymes
#13
Aifang Li, Nana Ma, Zijing Zhao, Mei Yuan, Hua Li, Qi Wang
BACKGROUND: Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible with licorice; the mechanism underlying this incompatibility has not been identified. Glycyrrhetinic acid (GA), the active metabolite of licorice, may increase the toxicity of bakuchiol (BAK), the main chemical ingredient in Psoralea corylifolia, by inhibiting its detoxification enzymes CYP450s...
2016: PeerJ
https://www.readbyqxmd.com/read/27901086/glycycoumarin-inhibits-hepatocyte-lipoapoptosis-through-activation-of-autophagy-and-inhibition-of-er-stress-gsk-3-mediated-mitochondrial-pathway
#14
Enxiang Zhang, Shutao Yin, Xinhua Song, Lihong Fan, Hongbo Hu
Herbal medicine as an alternative approach in the treatment of disease has drawn growing attention. Identification of the active ingredient is needed for effective utilization of the herbal medicine. Licorice is a popular herbal plant that is widely used to treat various diseases including liver diseases. Glycycoumarin (GCM) is a representative of courmarin compounds isolated from licorice. In the present study, the protective effect of GCM on hepatocyte lipoapoptosis has been evaluated using both cell culture model of palmitate-induced lipoapoptosis and animal model of non-alcoholic steatohepatitis (NASH)...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892811/simultaneous-determination-of-glycyrrhizin-and-liquiritin-in-licorice-roots-and-kampo-medicines-by-combination-enzyme-linked-immunosorbent-assay-using-anti-glycyrrhizin-and-anti-liquiritin-monoclonal-antibodies
#15
Shunsuke Fujii, Osamu Morinaga, Takuhiro Uto, Shuichi Nomura, Yukihiro Shoyama
Immunoassay systems using monoclonal antibodies (mAbs) are one of the most useful techniques in the analytical, biochemical, and clinical fields. In this study, a combination enzyme-linked immunosorbent assay (ELISA) using both anti-glycyrrhizin and anti-liquiritin mAbs (anti-GL/Liq mixture mAbs) was developed for quality control of licorice and its products. The combination ELISA demonstrated high sensitivity, reproducibility, and specificity for the total content of GL and Liq by a single assay. The developed ELISA was effective and useful as the first screening method in the selection of high-quality licorice from the Glycyrrhiza species and in confirming the quality of licorice-containing Kampo medicines...
November 28, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/27863401/isoliquiritigenin-decreases-the-incidence-of-colitis-associated-colorectal-cancer-by-modulating-the-intestinal-microbiota
#16
Minna Wu, Yaqi Wu, Baoguo Deng, Jinsong Li, Haiying Cao, Yan Qu, Xinlai Qian, Genshen Zhong
Imbalances in intestinal bacteria correlate with colitis-associated colorectal cancer (CAC). Traditional Chinese medicines have been used to adjust the gut microbiota, and isoliquiritigenin (ISL), a flavonoid extracted from licorice, has shown antitumor efficacy. In this study, the effects of ISL on CAC development and the gut microbiota were evaluated using an azoxymethane and dextran sulphate sodium (AOM/DSS)-induced mouse model of CAC (CACM). Histopathological analysis suggested that ISL reduced tumor incidence in vivo...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832784/antitussive-anti-pyretic-and-toxicological-evaluation-of-ma-xing-gan-shi-tang-in-rodents
#17
Yu-Chin Lin, Ching-Wen Chang, Chi-Rei Wu
BACKGROUND: Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects. METHODS: The pharmacological activities of MXGST extract in clinical use were investigated with citric acid-induced cough, acetylcholine/histamine-induced bronchial contraction and lipopolysaccharide (LPS)-induced fever in rodents...
November 10, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27830276/could-licorice-lick-inflammasomes
#18
EDITORIAL
Friedrich C Luft
No abstract text is available yet for this article.
December 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27815461/antiviral-and-antitumor-activity-of-licorice-root-extracts
#19
Kunihiko Fukuchi, Noriyuki Okudaira, Kazunori Adachi, Reina Odai-Ide, Shigeru Watanabe, Hirokazu Ohno, Masaji Yamamoto, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Yoshihiro Uesawa, Hajime Kagaya, Hiroshi Sakagami
BACKGROUND: In the search for anti-viral and antitumor substances from natural resources, antiviral and antitumor activities of licorice root extract and purified ingredients were investigated. MATERIALS AND METHODS: Viability of cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Antiviral activity was quantified by the selectivity index, defined as the ratio of the 50% cytotoxic concentration (CC50) to the 50% effective concentration against human immunodeficiency virus (HIV) or herpes simplex virus (HSV)-infected cells (EC50)...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27803670/poria-attenuates-idiosyncratic-liver-injury-induced-by-polygoni-multiflori-radix-praeparata
#20
Dan Gao, Jing-Yao Pang, Cong-En Zhang, Chun-Yu Li, Can Tu, Hai-Zhu Zhang, Ming Niu, Yin Xiong, Xiao-He Xiao, Kui-Jun Zhao, Wei-Wei Gao, Jia-Bo Wang
The hepatotoxicity induced by Polygoni Multiflori Radix Praeparata (PM) has aroused great concern throughout the world. Hence, it is worthwhile to perform studies on the detoxification with the combined use of medicinal herbs based on the compatibility theory of traditional Chinese medicine. In this work, the rat model of PM/LPS-induced idiosyncratic liver injury was used. The effects of Poria, Licorice, and Panax notoginseng on rats of PM/LPS-induced liver injury were investigated respectively, hoping to find the most effective herbal medicine to reduce the hepatotoxicity...
2016: Frontiers in Pharmacology
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