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https://www.readbyqxmd.com/read/29341803/licorice-pretreatment-protects-against-brain-damage-induced-by-middle-cerebral-artery-occlusion-in-mice
#1
Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim, Suin Cho
Licorice is extracted from the roots of plants in the Glycyrrhiza genus, especially Glycyrrhiza uralensis in China and Korea. It has several pharmacological activities, including neuro-protective, anti-fungal, and anti-cariogenic effects. Ischemia/reperfusion-induced brain injury is a leading cause of adult disability and death; thus, the identification of anti-apoptotic, neuro-protective therapeutic agents is viewed as an attractive drug development strategy. Infarct volumes and the expression of several apoptosis-related proteins, including Bcl-xL, Bcl-2, caspase-8, and caspase-9, were evaluated by western blotting in the brains of mice subjected to middle cerebral artery occlusion (MCAO)...
January 17, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29333390/physicochemical-and-consumer-acceptance-of-tofu-supplemented-with-licorice-powder
#2
Jun Ho Lee, Han San Jung
To develop functionally and nutritionally improved tofu, the effects of partial (0.2~0.8%) replacement with licorice powder (LP) on the quality characteristics of tofu were investigated. The pH and turbidity values decreased upon addition of increasing amounts of LP (P<0.05). The yield of LP-supplemented tofu was higher than that of the control tofu, and it increased as the concentration of LP increased (P<0.05). Substituting 0.6% and above of LP significantly hardened the texture of tofu (P<0.05) while control and 0...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29329835/in-depth-chemical-investigation-of-glycyrrhiza-triphylla-fisch-roots-guided-by-a-preliminary-hplc-esimsn-profiling
#3
Abolfazl Shakeri, Milena Masullo, Gilda D'Urso, Mehrdad Iranshahi, Paola Montoro, Cosimo Pizza, Sonia Piacente
Chemical investigations on Glycyrrhiza spp. have mostly been focused on G. glabra (typically cultivated in Europe, henceforth called European licorice), G. uralensis and G. inflata (known as Chinese licorice) with little information on the constituents of other Glycyrrhiza species. According to the growing interest in further Glycyrrhiza spp. to be used as sweeteners, the roots of G. triphylla have been investigated. The LC-ESI/LTQOrbitrap/MS profile of the methanolic extract of G. triphylla roots guided the isolation of 21 compounds, of which the structures were elucidated by 1D- and 2D-NMR experiments...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29321989/antidepressant-like-effects-of-gan-mai-dazao-tang-via-monoamine-regulatory-pathways-on-forced-swimming-test-in-rats
#4
Hsiang-Ling Huang, Swee-Ling Lim, Kuan-Hung Lu, Lee-Yan Sheen
Depression is a highly prevalent and recurrent mental disorder that impacts all aspects of human life. Undesirable effects of the antidepressant drugs led to the development of complementary and alternative therapies. Gan-Mai-Da-Zao-Tang (, gān mài dà zǎo tang) is a traditional herbal formula commonly used for the treatment of depression, but lack of scientific proof on its mechanism. It consisted of Glycyrrhiza uralensis Fisch. (licorice), Triticum aestivum L. (wheat) and Zizphus jujuba Mill. (jujube)...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29296565/optimization-of-ultrasound-assisted-extraction-of-glycyrrhizic-acid-from-licorice-using-response-surface-methodology
#5
Seol Jang, A Yeong Lee, A Reum Lee, Goya Choi, Ho Kyoung Kim
Background: The present study optimized ultrasound-assisted extraction conditions to maximize extraction yields of glycyrrhizic acid from licorice. Methods: The optimal extraction temperature (X1), extraction time (X2), and methanol concentration (X3) were identified using response surface methodology (RSM). A central composite design (CCD) was used for experimental design and analysis of the results to obtain the optimal processing parameters. Results: Statistical analyses revealed that three variables and the quadratic of X1, X2, and X3 had significant effects on the yields and were followed by significant interaction effects between the variables of X2 and X3 (p < 0...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29284971/assessment-of-total-antioxidant-capacity-and-antimicrobial-activity-of-glycyrrhiza-glabra-in-saliva-of-hiv-infected-patients
#6
Eby Aluckal, Asif Ismail, Anoopa Paulose, Sanju Lakshmanan, M S Balakrishnan, Benoy Mathew, Vikneshan M, Abraham Kunnilathu
Objectives: The objectives of this study were to evaluate the antimicrobial activity and total antioxidant capacity (TAC) of licorice in Saliva of HIV/AIDS patients. Materials and Methods: Saliva specimens were collected from 20 people living with HIV infection, with CD4 count <500 cells/mm3 from people infected with HIV/AIDS in Mangalore city, India. A combination of amoxicillin-clavulanic acid and nystatin was taken as the positive control and normal saline as negative control...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29246138/the-immunomodulatory-activities-of-licorice-polysaccharides-glycyrrhiza-uralensis-fisch-in-ct-26-tumor-bearing-mice
#7
Peter Amwoga Ayeka, YuHong Bian, Peter Mwitari Githaiga, Ying Zhao
BACKGROUND: The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we report the immunomodulatory activity of licorice polysaccharides in vivo. METHODS: The differential anticancer activities of licorice polysaccharides by tumorigenesis and immunomodulation was evaluated in vivo...
December 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29234377/the-ethanol-extract-of-licorice-glycyrrhiza-uralensis-protects-against-triptolide-induced-oxidative-stress-through-activation-of-nrf2
#8
Ling-Juan Cao, Zhen-Yan Hou, Huan-De Li, Bi-Kui Zhang, Ping-Fei Fang, Da-Xiong Xiang, Zhi-Hua Li, Hui Gong, Yang Deng, Yan-Xia Ma, Huai-Bo Tang, Miao Yan
To investigate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2) in licorice ethanol extract (LEE) against triptolide- (TP-) induced hepatotoxicity, HepG2 cells were exposed to LEE (30, 60, and 90 mg·L-1) for 12 h and then treated with TP (50 nM) for 24 h. Besides, an acute liver injury model was established in ICR mice by a single dose of TP (1.0 mg·kg-1, i.p.). Relevant oxidant and antioxidant mediators were analyzed. TP led to an obvious oxidative stress as evidenced by increasing levels of ROS and decreasing GSH contents in HepG2 cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29224994/antitussive-and-expectorant-activities-of-licorice-and-its-major-compounds
#9
Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye
Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30-78% (p < .01). The antitussive effects could be partially antagonized by the pretreatment of methysergide or glibenclamide, but not naloxone...
December 2, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29212198/targeting-oral-cancer-stemness-and-chemoresistance-by-isoliquiritigenin-mediated-grp78-regulation
#10
Fang-Wei Hu, Cheng-Chia Yu, Pei-Ling Hsieh, Yi-Wen Liao, Ming-Yi Lu, Pei-Ming Chu
Cancer stem cells (CSCs) are cells that drive tumorigenesis, contributing to metastasis and cancer recurrence as well as resistance to chemotherapy of oral squamous cell carcinomas (OSCC). Therefore, approaches to target CSCs become the subject of intense research for cancer therapy. In this study, we demonstrated that isoliquiritigenin, a chalcone-type flavonoid isolated from licorice root, exhibited more toxicity in oral cancer stem cells (OSCC-CSCs) compared to normal cells. Treatment of isoliquiritigenin not only inhibited the self-renewal ability but also reduced the expression of CSC markers, including the ALDH1 and CD44...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207188/glycyrrhizic-acid-induces-human-mda-mb-231-breast-cancer-cell-death-and-autophagy-via-the-ros-mitochondrial-pathway
#11
Shu-Chuan Lin, Pei-Yi Chu, Wan-Ting Liao, Meng-Yu Wu, Kuan-Hao Tsui, Li-Te Lin, Chih-Hao Huang, Li-Li Chen, Chia-Jung Li
Glycyrrhizic acid (GA), the main component of licorice root extracts, has been shown to suppress cell proliferation and induce apoptosis in various types of cancers. However, the molecular mechanism of its anticancer activity remains poorly understood and warrants further investigation. MDA-MB‑231 cells were treated with various concentrations of GA and the cytotoxic effects of GA were determined using the CCK-8 assay. Apoptosis and cell cycle status were detected by flow cytometry. Reactive oxygen species (ROS) levels and mitochondrial membrane potential (∆Ψm) were assessed using DCFDA, MitoSOX and JC-1 staining...
November 29, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29203272/comparison-of-the-inducible-effects-of-licorice-products-with-or-without-heat-processing-and-pre-treatment-with-honey-on-granulocyte-colony-stimulating-factor-secretion-in-cultured-enterocytes
#12
Misato Ota, Yasutaka Nagachi, Kan'ichiro Ishiuchi, Yoshiaki Tabuchi, Feng Xu, Ming-Ying Shang, Shao-Qing Cai, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: Licorice (the roots and rhizomes of Glycyrrhiza uralensis Fisch.) is occasionally used as crude drug following processing including roasting or honey-roasting (soaking with honey before roasting) in traditional Japanese Kampo medicine and traditional Chinese medicine (TCM). AIM OF THE STUDY: We investigated the differences in the inducible effect of processed licorice products on granulocyte colony-stimulating factor (G-CSF) secretion in cultured intestinal epithelial cells and elucidated the active ingredients in both unprocessed and processed licorice products...
December 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29198875/gancao-gansui-combination-impacts-gut-microbiota-diversity-and-related-metabolic-functions
#13
Jingao Yu, Jianming Guo, Weiwei Tao, Pei Liu, Erxin Shang, Zhenhua Zhu, Xiuhe Fan, Juan Shen, Yongqing Hua, Kevin Yue Zhu, Yuping Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The theory of "eighteen incompatible medicaments" (EIM) in traditional Chinese medicine (TCM) is the most representative case of herbal-herbal interactions. Gancao and Gansui are one of the incompatible herbal pairs in EIM. Gancao, also known as "licorice", is the most frequently used Chinese herb or food additive. Gansui, the root of Euphorbia kansui T.P. Wang, is another famous Chinese herb usually used to treat edema, ascites and asthma but could induce gastrointestinal (GI) tract irritation...
November 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29196123/boosting-11-oxo-%C3%AE-amyrin-and-glycyrrhetinic-acid-synthesis-in-saccharomyces-cerevisiae-via-pairing-novel-oxidation-and-reduction-system-from-legume-plants
#14
Ming Zhu, Caixia Wang, Wentao Sun, Anqi Zhou, Ying Wang, Genlin Zhang, Xiaohong Zhou, Yixin Huo, Chun Li
Glycyrrhetinic acid (GA) and its precursor, 11-oxo-β-amyrin, are typical triterpenoids found in the roots of licorice, a traditional Chinese medicinal herb that exhibits diverse functions and physiological effects. In this study, we developed a novel and highly efficient pathway for the synthesis of GA and 11-oxo-β-amyrin in Saccharomyces cerevisiae by introducing efficient cytochrome P450s (CYP450s: Uni25647 and CYP72A63) and pairing their reduction systems from legume plants through transcriptome and genome-wide screening and identification...
November 28, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29191092/plant-derived-isoprenoid-sweeteners-recent-progress-in-biosynthetic-gene-discovery-and-perspectives-on-microbial-production
#15
Hikaru Seki, Keita Tamura, Toshiya Muranaka
Increased public awareness of negative health effects associated with excess sugar consumption has triggered increasing interest in plant-derived natural sweeteners. Steviol glycosides are a group of highly sweet diterpene glycosides contained in the leaves of stevia (Stevia rebaudiana). Mogrosides, extracted from monk fruit (Siraitia grosvenorii), are a group of cucurbitane-type triterpenoid glycosides. Glycyrrhizin is an oleanane-type triterpenoid glycoside derived from the underground parts of Glycyrrhiza plants (licorice)...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29184760/rhabdomyolysis-with-different-etiologies-in-childhood
#16
Demet Alaygut, Meral Torun Bayram, Belde Kasap, Alper Soylu, Mehmet Türkmen, Salih Kavukcu
AIM: To investigate different etiologies and management of the rhabdomyolysis in children. METHODS: Eight pediatric rhabdomyolysis cases who applied to the Dokuz Eylul University Faculty of Medicine Department of Pediatric Nephrology with different etiologies between January 2004 and January 2012 were evaluated in terms of age, gender, admission symptoms, physical examination findings, factors provoking rhabdomyolysis, number of rhabdomyolysis attacks, laboratory results, family history and the final diagnosis received after the treatment...
November 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29182728/an-evaluation-of-the-impact-of-aloe-vera-and-licorice-extracts-on-the-course-of-experimental-pigeon-paramyxovirus-type-1-infection-in-pigeons
#17
D Dziewulska, T Stenzel, M Smialek, B Tykalowski, A Koncicki
The progressive decrease in the efficiency of synthetic drugs has prompted research into phytogenic feed additives with potentially immunomodulatory and anti-infective properties. Complex diseases with a mixed etiology, including viral, pose a growing problem in domestic pigeons. The aim of this study was to determine the effectiveness of various doses of aloe vera and licorice extracts on the course of experimental PPMV-1 infection in pigeons. The experiment was performed on pigeons divided into 5 groups, including one control group and 4 experimental groups, which were orally administered aloe vera or licorice extracts at 300 or 500 mg/kg BW for 7 d after experimental inoculation with PPMV-1...
November 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/29179542/a-perspective-on-biotransformation-and-de-novo-biosynthesis-of-licorice-constituents
#18
Yujia Zhao, Bo Lv, Xudong Feng, Chun Li
Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco and cosmetics industries with high economic value. However, over-exploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and bioengineering methods is a hot spot in recent years. In this perspective, we comprehensively summarize the biotransformation of licorice constituents into high value-added derivatives by biocatalysts...
November 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29150398/glycyrrhiza-glabra-extract-and-quercetin-reverses-cisplatin-resistance-in-triple-negative-mda-mb-468-breast-cancer-cells-via-inhibition-of-cytochrome-p450-1b1-enzyme
#19
Rajni Sharma, Linda Gatchie, Ibidapo S Williams, Shreyans K Jain, Ram A Vishwakarma, Bhabatosh Chaudhuri, Sandip B Bharate
The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With an objective to discover cisplatin-resistance reversal agents, herein, we report the evaluation of Glycyrrhiza glabra (licorice) extracts and its twelve chemical constituents for inhibition of CYP1B1 (and CYP1A1) enzyme in Sacchrosomes and live human cells. The hydroalcoholic extract showed potent inhibition of CYP1B1 in both Sacchrosomes as well as in live cells with IC50 values of 21 and 16 µg/mL, respectively...
November 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29149693/near-infrared-spectroscopy-based-monitoring-of-extraction-processes-of-raw-material-with-the-help-of-dynamic-predictive%C3%A2-modeling
#20
Haixia Wang, Tongchuan Suo, Xiaolin Wu, Yue Zhang, Chunhua Wang, Heshui Yu, Zheng Li
The control of batch-to-batch quality variations remains a challenging task for pharmaceutical industries, e.g., traditional Chinese medicine (TCM) manufacturing. One difficult problem is to produce pharmaceutical products with consistent quality from raw material of large quality variations. In this paper, an integrated methodology combining the near infrared spectroscopy (NIRS) and dynamic predictive modeling is developed for the monitoring and control of the batch extraction process of licorice. With the spectra data in hand, the initial state of the process is firstly estimated with a state-space model to construct a process monitoring strategy for the early detection of variations induced by the initial process inputs such as raw materials...
November 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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