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https://www.readbyqxmd.com/read/28293388/protective-role-of-licochalcone-b-against-ethanol-induced-hepatotoxicity-through-regulation-of-erk-signaling
#1
Xiao-Peng Gao, Dong-Wei Qian, Zhen Xie, Hao Hui
OBJECTIVES: Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. MATERIALS AND METHODS: An in vitro model of Ethanol-induced cytotoxicity in BRL cells was used in this study. Cell injury was assessed using WST-1 assay and lactate dehydrogenase, alanine transaminase, and aspartate aminotransferase release assay...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28276791/licorice-induced-hypertension-a-case-of-pseudohyperaldosteronism-due-to-jelly-bean-ingestion
#2
Christopher A Foster, Kristen S Church, Megha Poddar, Stan H M Van Uum, Tamara Spaic
Hypertension is one of the most common problems encountered in the primary care setting. Numerous secondary causes of hypertension exist and are potentially reversible. The ability to screen for such causes and manage them effectively may spare patients from prolonged medical therapy and hypertensive complications. Licorice can cause hypertension and hypokalemia due its effects on cortisol metabolism. We report a case of jelly bean ingestion that highlights the presentation, pathophysiology and management of licorice-induced hypertension...
February 15, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28272690/licorice-and-its-active-compound-glycyrrhizic-acid-ameliorates-cisplatin-induced-nephrotoxicity-through-inactivation-of-p53-by-scavenging-ros-and-overexpression-of-p21-in-human-renal-proximal-tubular-epithelial-cells
#3
S-M Ju, M-S Kim, Y-S Jo, Y-M Jeon, J-S Bae, H-O Pae, B-H Jeon
OBJECTIVE: Nephrotoxicity is one of the major side effects that limit the use of cisplatin in cancer therapy. Cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ROS)-mediated p53 activation. Licorice (Glycyrrhiza uralensis Fischer) is one of the most widely used medicinal herbs in Korea, China and Japan. The aim of the study was to evaluate the protective effects of licorice extract (LE) and its active compound glycyrrhizic acid (GA) against cisplatin-induced nephrotoxicity in human renal proximal tubular epithelial (HK-2) cells...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28272545/glycyrrhiza-uralensis-water-extract-enhances-dendritic-cell-maturation-and-antitumor-efficacy-of-hpv-dendritic-cell-based-vaccine
#4
Adila Aipire, Jinyu Li, Pengfei Yuan, Jiang He, Yelang Hu, Lu Liu, Xiaoli Feng, Yijie Li, Fuchun Zhang, Jianhua Yang, Jinyao Li
Licorice has been used as herbal medicine and natural sweetener. Here, we prepared Glycyrrhiza uralensis water extract (GUWE) and investigated the effect of GUWE on the maturation and function of dendritic cells (DCs) and its adjuvant effect on DC-based vaccine. We observed that GUWE dose-dependently promoted DC maturation and cytokine secretion through TLR4 signaling pathway. The capacity of DC to stimulate allogenic splenocyte proliferation was also enhanced by GUWE treatment. Compared with control group, GUWE treated DCs pulsed with human papillomavirus (HPV)-16 E6/E7 peptides significantly inhibited the tumor growth in both early and late therapeutic groups...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28238265/new-sweet-tasting-oleanane-type-triterpenoid-saponins-from-tugancao-derris-eriocarpa-how
#5
Hong-Xia Zhang, Guo Sun, Jian-Long Gu, Zhi-Zhi Du
With the aim to investigate the sweet-tasting compounds in Derris eriocarpa How (a substitute for licorice in "Zhuang" and "Dai" ethnopharmacy in Guangxi and Yunnan provinces of China) as well as to ascertain why the stem of D. eriocarpa can be used to substitute for licorice in the sweetness taste aspect, taste sensory-guided fractionation was conducted to isolate sweet constituents from the extract of D. eriocarpa. Four sweet-tasting triterpenoid saponins were obtained, including millettiasaponin A (1) and three new saponins named derrisaponins A-C (2-4)...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28229156/protective-effect-of-isoliquiritin-against-corticosterone-induced-neurotoxicity-in-pc12-cells
#6
Yu-Zhi Zhou, Xiao Li, Wen-Xia Gong, Jun-Sheng Tian, Xiao-Xia Gao, Li Gao, Xiang Zhang, Guan-Hua Du, Xue-Mei Qin
Isoliquiritin, a flavonoid glycoside compound from licorice, possesses a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory and anti-depression activities. However, the neuroprotective mechanisms of antidepressant effects remain unclear. In this study, the aim was to investigate the cytoprotective efficiency and potential mechanisms of isoliquiritin in corticosterone-damaged PC12 cells. The results of this study showed that pretreatment of PC12 cells with isoliquiritin significantly prevented corticosterone-induced cell apoptosis...
February 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28221957/ochratoxin-a-concentrations-in-a-variety-of-grain-based-and-non-grain-based-foods-on-the-canadian-retail-market-from-2009-to-2014
#7
Beata Kolakowski, Sarah M O'Rourke, Henri P Bietlot, Karl Kurz, Barbara Aweryn
The extent of ochratoxin A (OTA) contamination of domestically produced foods sold across Canada was determined from 2009 to 2014 with sampling and testing occurring each fiscal year. Cereal-based, fruit-based, and soy-based food samples (n = 6,857) were analyzed. Almost half of the samples (3,200; 47%) did not contain detectable concentrations of OTA. The remaining 3,657 samples contained OTA at 0.040 to 631 ng/g. Wheat, oats, milled products of other grains (such as rye and buckwheat), and to a lesser extent corn products and their derived foods were the most significant potential sources of OTA exposure for the Canadian population...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221885/antibacterial-and-antiadhesive-activities-of-extracts-from-edible-plants-against-soft-drink-spoilage-by-asaia-spp
#8
Hubert Antolak, Agata Czyzowska, Dorota Kregiel
This study was conducted to investigate the antibacterial and antiadhesive activities of ethanol extracts from five edible plant parts: cinnamon bark ( Cinnamomum zeylanicum ), licorice root ( Glycyrrhiza radix ), nettle leaves ( Urtica dioica ), green tea leaves ( Camellia sinensis ), and elderberry flowers ( Sambucus nigra ). The chemical constituents of the extracts were identified using high-performance liquid chromatography and liquid chromatography plus mass spectrometry. Six strains of Asaia lannensis and Asaia bogorensis bacteria isolated from spoiled commercial fruit-flavored noncarbonated mineral water were used...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28213090/glycyrrhetinic-acid-attenuates-lipopolysaccharide-induced-fulminant-hepatic-failure-in-d-galactosamine-sensitized-mice-by-up-regulating-expression-of-interleukin-1-receptor-associated-kinase-m
#9
Xinru Yin, Xia Gong, Li Zhang, Rong Jiang, Ge Kuang, Bin Wang, Xinyu Chen, Jingyuan Wan
Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN) administration. In other in vitro experiment, RAW264.7 macrophages were pretreated with GA before LPS exposure. The mortality, hepatic tissue histology, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed...
February 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28192986/biosynthesis-based-quantitative-analysis-of-151-secondary-metabolites-of-licorice-to-differentiate-medicinal-glycyrrhiza-species-and-their-hybrids
#10
Wei Song, Xue Qiao, Kuan Chen, Ying Wang, Shuai Ji, Jin Feng, Kai Li, Yan Lin, Min Ye
Secondary metabolites are usually the bioactive components of medicinal plants. The difference in the secondary metabolisms of closely related plant species and their hybrids has rarely been addressed. In this study, we conducted a holistic secondary metabolomics analysis of three medicinal Glycyrrhiza species (G. uralensis, G. glabra, and G. inflata), which are used as the popular herbal medicine licorice. The Glycyrrhiza species (genotype) for 95 batches of samples were identified by DNA barcodes of the internal transcribed spacer and trnV-ndhC regions, and the chemotypes were revealed by LC/UV- or LC/MS/MS-based quantitative analysis of 151 bioactive secondary metabolites, including 17 flavonoid glycosides, 24 saponins, and 110 free phenolic compounds...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28175983/glycyrrhizin-inhibits-porcine-epidemic-diarrhea-virus-infection-and-attenuates-the-proinflammatory-responses-by-inhibition-of-high-mobility-group-box-1-protein
#11
Chang-Chao Huan, Hua-Xia Wang, Xiang-Xiang Sheng, Rui Wang, Xin Wang, Xiang Mao
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV) infection, leads to significant economic losses in the swine industry worldwide. In our studies, we found that glycyrrhizin, the major component of licorice root extracts, could moderately inhibit PEDV infection in Vero cells, when analyzed by western blot, qRT-PCR and a plaque formation assay. We also revealed that glycyrrhizin inhibited the entry and replication of PEDV. In addition, we demonstrated that glycyrrhizin decreased the mRNA levels of proinflammatory cytokines...
February 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28158597/maternal-licorice-consumption-during-pregnancy-and-pubertal-cognitive-and-psychiatric-outcomes-in-children
#12
Katri Räikkönen, Silja Martikainen, Anu-Katriina Pesonen, Jari Lahti, Kati Heinonen, Riikka Pyhälä, Marius Lahti, Soile Tuovinen, Karoliina Wehkalampi, Sara Sammallahti, Liisa Kuula, Sture Andersson, Johan G Eriksson, Alfredo Ortega-Alonso, Rebecca M Reynolds, Timo E Strandberg, Jonathan R Seckl, Eero Kajantie
No abstract text is available yet for this article.
February 3, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28140583/glycybridins-a-k-bioactive-phenolic-compounds-from-glycyrrhiza-glabra
#13
Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye
In an attempt to discover bioactive agents from the herbal medicine Glycyrrhiza glabra (widely known as licorice), 11 new phenolic compounds, glycybridins A-K (1-11), along with 47 known phenolics (12-58) were isolated. Their structures were elucidated on the basis of extensive NMR and MS analyses as well as experimental and computed ECD data. According to the clinical therapeutic effects of licorice, enzyme or cell-based bioactivity screenings of 1-58 were conducted. A number of compounds significantly activate Nrf2, inhibit tyrosinase or PTP1B, inhibit LPS-induced NO production and NF-κB transcription, and inhibit the proliferation of human cancer cells (HepG2, SW480, A549, MCF7)...
February 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28111219/antioxidative-and-anticancer-properties-of-licochalcone-a-from-licorice
#14
Xiangrong Chen, Zuojia Liu, Rizeng Meng, Ce Shi, Na Guo
ETHNOPHARMACOLOGICAL RELEVANCE: Licochalcone A (LCA) is a characteristic chalcone that is found in licorice, which is a traditional medicinal plant. In traditional medicine, LCA possesses many potential biological activities, including anti-parasitic, anti-inflammatory and antitumor activities. AIM OF THE STUDY: To determine the antioxidant activity of LCA and, on this basis, to investigate the role of its anticancer activity. MATERIALS AND METHODS: To validate the antioxidant activity of LCA, the proteins SOD, CAT and GPx1 were analyzed using western blotting and cellular antioxidant activity (CAA) assays...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28108937/glycyrrhizin-ameliorates-experimental-colitis-through-attenuating-interleukin-17-producing-t-cell-responses-via-regulating-antigen-presenting-cells
#15
Xiangyu Chen, Dai Fang, Lingyun Li, Liyong Chen, Qirui Li, Feili Gong, Min Fang
Glycyrrhizin, a component of Chinese medicine licorice root, has the ability to inhibit the functions of high-mobility group box 1 (HMGB1). While glycyrrhizin is known to have anti-inflammatory activities, the underlying mechanisms by which glycyrrhizin inhibits inflammation during the development of trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis are not well understood. This study systemically examined the regulatory effects of glycyrrhizin on inflammatory response in TNBS-induced murine colitis and explored the potential mechanisms involved in this process...
January 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28090048/hyponatremia-in-an-elderly-patient-due-to-isolated-hypoaldosteronism-occurring-after-licorice-withdrawal
#16
Yuji Hataya, Akifumi Oba, Takafumi Yamashita, Yasato Komatsu
Hyponatremia is one of the most common electrolyte disorders encountered in the elderly. We present the case of an 81-year-old man who developed hyponatremia due to isolated hypoaldosteronism occurring after licorice withdrawal. He had severe hypokalemia with hypertension and was diagnosed with pseudoaldosteronism. He had been taking a very small dose of licorice as a mouth refresher since his early adulthood. Five months after licorice withdrawal, he developed hypovolemic hyponatremia, which was resolved with administration of fludrocortisone acetate...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28087760/molecularly-imprinted-solid-phase-extraction-using-bismethacryloyl-%C3%AE-cyclodextrin-and-methacrylic-acid-as-double-functional-monomers-for-selective-analysis-of-glycyrrhizic-acid-in-aqueous-media
#17
Weili Tang, Wei Du, Pengqi Guo, Ningli Wu, Kangli Du, Changgen Xu, Zhimin Luo, Ruimiao Chang, Aiguo Zeng, Wanghui Jing, Chun Chang, Ji Li, Qiang Fu
In this work, a new molecularly imprinted solid phase extraction protocol was developed for the selective extraction and purification of glycyrrhizic acid from liquorice roots in aqueous media. The molecularly imprinted polymers (MIPs) for glycyrrhizic acid were prepared by using bismethacryloyl-β-cyclodextrin and methacrylic acid as double functional monomers and characterized by Fourier transform infrared spectroscopy, scanning electron microscope, thermo gravimetric analysis, nitrogen adsorption and elemental analysis...
February 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28055288/eveningness-as-a-risk-for-behavioral-problems-in-late-adolescence
#18
Ilona Merikanto, Anu-Katriina Pesonen, Liisa Kuula, Jari Lahti, Kati Heinonen, Eero Kajantie, Katri Räikkönen
Circadian preference toward eveningness has been associated with increased risk for mental health problems both in early adolescence and in adulthood. However, in late adolescence, when circadian rhythm naturally shifts to later, its significance for mental health is not clear. Accordingly, we studied how circadian rhythm estimated both by self-reported chronotype and by actigraph-defined midpoint of sleep was associated with self-reported psychiatric problems based on Youth Self Report (YSR). The study builds on a community cohort born in 1998, Helsinki, Finland...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28045565/the-effect-of-licorice-protein-fractions-on-proliferation-and-apoptosis-of-gastrointestinal-cancer-cell-lines
#19
Soheila Khazraei-Moradian, Mazdak Ganjalikhani-Hakemi, Alireza Andalib, Reza Yazdani, Javad Arasteh, Gholam Ali Kardar
BACKGROUND: Several methods for the treatment of colon cancer have been introduced, but none of them are safe and effective. We planned to evaluate the inhibitory effect of protein extract of licorice root on HT-29 and CT26 cell lines proliferation and apoptosis. METHODS: Protein extract of licorice root was prepared in phosphate-buffered solution, and SDS-PAGE was used to isolate its fractions. HT-29, CT-26, and HEK293 cell lines were treated with various concentrations of the fractions and full extract of licorice...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28031830/development-of-diffuse-alveolar-damage-after-initiation-of-nijutsuto
#20
Motoyasu Kato, Shinichi Sasaki, Hiroshi Izumi, Toshimasa Uekusa, Shigeru Tominaga, Kazuhisa Takahashi
Chinese traditional medicine, Nijutsuto, is used to treat patients with frozen shoulder and osteoarthritis. Herbal medicine is often linked to the development of interstitial lung disease. An 83-year-old Japanese man with osteoarthritis who was on Nijutsuto was admitted to our hospital with dyspnoea and severe cough after 2 weeks from initiation of Nijutsuto. A chest computed tomography scan on admission showed diffuse ground glass opacity with traction bronchiectasis. Thus, he was diagnosed with Nijutsuto-induced interstitial lung disease, and was treated with a high dose of methylprednisolone and cyclophosphamide...
November 2016: Respirology Case Reports
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