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https://www.readbyqxmd.com/read/29763790/the-language-of-smell-connecting-linguistic-and-psychophysical-properties-of-odor-descriptors
#1
Georgios Iatropoulos, Pawel Herman, Anders Lansner, Jussi Karlgren, Maria Larsson, Jonas K Olofsson
The olfactory sense is a particularly challenging domain for cognitive science investigations of perception, memory, and language. Although many studies show that odors often are difficult to describe verbally, little is known about the associations between olfactory percepts and the words that describe them. Quantitative models of how odor experiences are described in natural language are therefore needed to understand how odors are perceived and communicated. In this study, we develop a computational method to characterize the olfaction-related semantic content of words in a large text corpus of internet sites in English...
May 12, 2018: Cognition
https://www.readbyqxmd.com/read/29753766/licorice-flavonoid-oil-enhances-muscle-mass-in-kk-a-y-mice
#2
Yasukiyo Yoshioka, Yoko Yamashita, Hideyuki Kishida, Kaku Nakagawa, Hitoshi Ashida
AIMS: Muscle mass is regulated by the balance between the synthesis and degradation of muscle proteins. Loss of skeletal muscle mass is associated with an increased risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. The aim of this study was to clarify the effects of licorice flavonoid oil on muscle mass in KK-Ay /Ta mice. MAIN METHODS: Male genetically type II diabetic KK-Ay /Ta mice received 0, 1, or 1.5 g/kg BW of licorice flavonoid oil by mouth once daily for 4 weeks...
May 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29740326/using-ssr-hrm-to-identify-closely-related-species-in-herbal-medicine-products-a-case-study-on-licorice
#3
Jingjian Li, Chao Xiong, Xia He, Zhaocen Lu, Xin Zhang, Xiaoyang Chen, Wei Sun
Traditional herbal medicines have played important roles in the ways of life of people around the world since ancient times. Despite the advanced medical technology of the modern world, herbal medicines are still used as popular alternatives to synthetic drugs. Due to the increasing demand for herbal medicines, plant species identification has become an important tool to prevent substitution and adulteration. Here we propose a method for biological assessment of the quality of prescribed species in the Chinese Pharmacopoeia by use of high resolution melting (HRM) analysis of microsatellite loci...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29721581/glycyrrhizin-suppresses-rankl-induced-osteoclastogenesis-and-oxidative-stress-through-inhibiting-nf-%C3%AE%C2%BAb-and-mapk-and-activating-ampk-nrf2
#4
Zhikun Li, Chao Chen, Xiaodong Zhu, Yifan Li, Ronghua Yu, Wei Xu
The treatment for osteoporosis involves inhibiting bone resorption and osteoclastogenesis. Glycyrrhizin (GLY) is a triterpenoid saponin glycoside known to be as the most medically efficacious component of the licorice plant. It has strong anti-inflammatory, antioxidant, and antitumor properties. We investigated the effect of GLY on osteoclastogenesis, bone resorption, and intracellular oxidative stress and its molecular mechanisms. In vitro osteoclastogenesis assays were performed using bone marrow monocytes with and without glycyrrhizin...
May 2, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29716604/the-impact-of-aloe-vera-and-licorice-extracts-on-selected-mechanisms-of-humoral-and-cell-mediated-immunity-in-pigeons-experimentally-infected-with-ppmv-1
#5
Daria Dziewulska, Tomasz Stenzel, Marcin Śmiałek, Bartłomiej Tykałowski, Andrzej Koncicki
BACKGROUND: The aim of the study was to evaluate the impact of herbal extracts on selected immunity mechanisms in clinically healthy pigeons and pigeons inoculated with the pigeon paramyxovirus type 1 (PPMV-1). For the first 7 days post-inoculation (dpi), an aqueous solution of Aloe vera or licorice extract was administered daily at 300 or 500 mg/kg body weight (BW). The birds were euthanized at 4, 7 and 14 dpi, and spleen samples were collected during necropsy. Mononuclear cells were isolated from spleen samples and divided into two parts: one part was used to determine the percentage of IgM+ B cells in a flow cytometric analysis, and the other was used to evaluate the expression of genes encoding IFN-γ and surface receptors on CD3+ , CD4+ and CD8+ T cells...
May 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29710547/nf-%C3%AE%C2%BAb-and-nrf2-pathways-contribute-to-the-protective-effect-of-licochalcone-a-on-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice
#6
Dongyu Liu, Xiaowei Huo, Li Gao, Juan Zhang, Hui Ni, Li Cao
Licochalcone A (Lico A) is a characteristic chalcone isolated from licorice root which is widely recognized in traditional Chinese medicine for the ability of anti-inflammatory, antioxidant, anti-parasitic and anti-cancer. The present study was aimed to investigate the effect of Lico A on dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in a mouse model which was induced by administration of 3% DSS in drinking water. Mice were then treated with Lico A (20, 40 and 80 mg/kg, p.o.) or 0.9% saline (20 ml/kg, p...
March 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709906/dibenzoylmethane-suppresses-lipid-accumulation-and-reactive-oxygen-species-production-through-regulation-of-nuclear-factor-erythroid-derived-2-like-2-and-insulin-signaling-in-adipocytes
#7
Joo Hyoun Kim, Chae Young Kim, Bobin Kang, Jungil Hong, Hyeon-Son Choi
The aim of this study was to investigate the effects of dibenzoylmethane (1,3-diphenyl-1,3-propanedione, DBM) from licorice roots on lipid accumulation and reactive oxygen species (ROS) production in 3T3-L1 cells. DBM effectively inhibited lipid accumulation during adipogenesis, and its inhibitory effect was shown to be due to the down-regulation of adipogenic factors such as CCAAT-enhancer-binding protein-α (C/EBPα), peroxisome proliferator-activated receptor γ (PPARγ), and fatty acid-binding protein 4 (FABP4)...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29702284/glycyrrhizin-ameliorates-atopic-dermatitis-like-symptoms-through-inhibition-of-hmgb1
#8
Ying Wang, Yue Zhang, Ge Peng, Xiuping Han
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease prevalent worldwide. This study investigated the effects of glycyrrhizin, an extract of licorice root, on the well-established model of 2,4-dinitrochlorobenzene-induced AD-like symptoms in mice. The severity of dermatitis, histopathological changes, serum IgE levels, changes in expression of high-mobility group box 1 (HMGB1), the receptor for advanced glycation end products (RAGE), nuclear factor (NF)-κB and inflammatory cytokines were evaluated...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29682439/development-of-cleaved-amplified-polymorphic-sequence-caps-and-high-resolution-melting-hrm-markers-from-the-chloroplast-genome-of-glycyrrhiza-species
#9
Ick-Hyun Jo, Jwakyung Sung, Chi-Eun Hong, Sebastin Raveendar, Kyong-Hwan Bang, Jong-Wook Chung
Licorice ( Glycyrrhiza glabra ) is an important medicinal crop often used as health foods or medicine worldwide. The molecular genetics of licorice is under scarce owing to lack of molecular markers. Here, we have developed cleaved amplified polymorphic sequence (CAPS) and high-resolution melting (HRM) markers based on single nucleotide polymorphisms (SNP) by comparing the chloroplast genomes of two Glycyrrhiza species ( G. glabra and G. lepidota ). The CAPS and HRM markers were tested for diversity analysis with 24 Glycyrrhiza accessions...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29676130/-application-of-dna-based-electrochemical-biosensor-in-rapid-detection-of-escherichia-coli-exist-in-licorice-decoction
#10
Yu-Wen Zhao, Hai-Xia Wang, Song-Tao Bie, Qian Shao, Chun-Hua Wang, Dong-Heng Wang, Zheng Li
A new method for detection of Escherichia coli exist in licorice decoction was developed by using DNA-based electrochemical biosensor. The thiolated capture probe was immobilized on a gold electrode at first. Then the aptamer for Escherichia coli was combined with the capture probe by hybridization. Due to the stronger interaction between the aptamer and the E. coli, the aptamer can dissociate from the capture probe in the presence of E. coli in licorice decoction. The biotinylated detection probe was hybridized with the single-strand capture probe...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676119/-optimize-preparation-of-compound-licorice-microemulsion-with-d-optimal-design
#11
Shu-Wei Ma, Yong-Jie Wang, Cheng Chen, Yue Qiu, Qing Wu
In order to increase the solubility of essential oil in compound licorice microemulsion and improve the efficacy of the decoction for treating chronic eczema, this experiment intends to prepare the decoction into microemulsion. The essential oil was used as the oil phase of the microemulsion and the extract was used as the water phase. Then the microemulsion area and maximum ratio of water capacity was obtained by plotting pseudo-ternary phase diagram, to determine the appropriate types of surfactant and cosurfactant, and Km value-the mass ratio between surfactant and cosurfactant...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674401/licorice-induced-apparent-mineralocorticoid-excess-compounded-by-excessive-use-of-terbutaline-and-high-water-intake
#12
Laust Frisenberg Buhl, Frederik Nørregaard Pedersen, Marianne Skovsager Andersen, Dorte Glintborg
This case highlights the clinical course of a 54-year-old male patient presenting with hypertension and long-term refractory hypokalaemia. He reported long-term malaise, fatigue and physical discomfort. Diarrhoea, vomiting, over-the-counter drugs, dietary supplements and any kind of medical abuse were all denied. Physical examination was normal. Suppressed plasma renin activity along with a low aldosterone level and elevated urinary cortisone/cortisol metabolite excretion ratio raised the suspicion of apparent mineralocorticoid excess (AME)...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29670847/changes-of-insulin-resistance-and-adipokines-following-supplementation-with-glycyrrhiza-glabra-l-extract-in-combination-with-a-low-calorie-diet-in-overweight-and-obese-subjects-a-randomized-double-blind-clinical-trial
#13
Mohammad Alizadeh, Nazli Namazi, Elham Mirtaheri, Nafiseh Sargheini, Sorayya Kheirouri
Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried licorice extract along with a calorie restricted diet on body composition, insulin resistance and adipokines in overweight and obese subjects. Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29665498/glabridin-an-isoflavan-from-licorice-root-ameliorates-imiquimod-induced-psoriasis-like-inflammation-of-balb-c-mice
#14
Penghui Li, Yonglian Li, Hong Jiang, Yuting Xu, Xiaoying Liu, Biao Che, Jian Tang, Guangrong Liu, Yadong Tang, Wei Zhou, Langyue Zhang, Changzhi Dong, Huixiong Chen, Kun Zhang, Zhiyun Du
In this paper, we investigate the effect of glabridin (Glab) on psoriasis. We observed that Glab significantly suppressed the levels of nitric oxide (NO), NF-κB subunit p65, interleukin (IL)-6, and IL-1β in lipopolysaccharide (LPS)-stimulated HaCaT cells. In addition, Glab treatment reduced the expression of IL-17A, IL-22, and IL-23 in TNF-α-stimulated-HaCaT cells. These findings prompted us to test whether Glab could be used to treat psoriasis in vivo. The effects of Glab on PASI scores, histopathological changes, oxidative/anti-oxidative indexes and pro-inflammatory cytokines in IMQ-induced mice were investigated...
April 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29663662/glabridin-induces-apoptosis-and-cell-cycle-arrest-in-oral-cancer-cells-through-the-jnk1-2-signaling-pathway
#15
Chang-Tai Chen, Yi-Tzu Chen, Yi-Hsien Hsieh, Chia-Jui Weng, Jung-Chun Yeh, Shun-Fa Yang, Chiao-Wen Lin, Jia-Sin Yang
Glabridin, a flavonoid extracted from licorice (Glycyrrhiza glabra), possesses various biological properties, including anticancer activities. However, the effect of glabridin on oral cancer cell apoptosis and the underlying molecular mechanisms has not been elucidated. In this study, we demonstrated that glabridin treatment significantly inhibits cell proliferation in human oral cancer SCC-9 and SAS cell lines. Flow cytometric assays demonstrated that glabridin induced several features of apoptosis, such as sub-G1 phase cell increase and phosphatidylserine externalization...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29648666/the-basic-helix-loop-helix-transcription-factor-gubhlh3-positively-regulates-soyasaponin-biosynthetic-genes-in-glycyrrhiza-uralensis
#16
Keita Tamura, Koki Yoshida, Yasuko Hiraoka, Daiki Sakaguchi, Ayaka Chikugo, Keiichi Mochida, Mareshige Kojoma, Nobutaka Mitsuda, Kazuki Saito, Toshiya Muranaka, Hikaru Seki
Glycyrrhiza uralensis (licorice) is a widely used medicinal plant belonging to the Fabaceae. Its main active component, glycyrrhizin, is an oleanane-type triterpenoid saponin widely used as a medicine and as a natural sweetener. Licorice also produces other triterpenoids, including soyasaponins. Recent studies have revealed various oxidosqualene cyclases and cytochrome P450 monooxygenases (P450s) required for the biosynthesis of triterpenoids in licorice. Of these enzymes, β-amyrin synthase (bAS) and β-amyrin C-24 hydroxylase (CYP93E3) are involved in the biosynthesis of soyasapogenol B (an aglycone of soyasaponins) from 2,3-oxidosqualene...
April 1, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29618444/the-genetic-and-chemical-diversity-in-three-original-plants-of-licorice-glycyrriza-uralensis-fisch-glycyrrhiza-inflata-bat-and-glycyrrhiza-glabra-l
#17
Rui Yang, Wendong Li, Bochuan Yuan, Guangxi Ren, Liqiang Wang, Ting Cheng, Ying Liu
Licorice is one of the most frequently used Chinese herbs, mainly containing triterpenoids and flavonoids. Three original plants, Glycyrrhiza glabra L., Glycyrrhiza uralensis Fisch., and Glycyrrhiza inflata Bat., are defined as licorice in Chinese pharmacopeia. In this study, 40 G. uralensis samples (Group A), 60 G. glabra samples (Group B, C and D) and 40 G. inflata samples (Group E and F), were used as plant materials, the genetic diversity of samples were determined by gene sequencing technology and the chemotypic diversity were detected by HPLC...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29600554/preparation-and-evaluation-of-open-tubular-capillary-column-combining-a-metal-organic-framework-and-a-brush-shaped-polymer-for-liquid-chromatography
#18
Kai Chen, Lingyi Zhang, Weibing Zhang
In this work, an open tubular capillary liquid-phase column was prepared by modifying chain polymer on the inner surface of capillary and chemical bonding of metal organic frameworks, NH2 -UiO-66, to the brushes of chain polymer (poly(glycidyl methacrylate)). Besides advantages of facial preparation and good permeability, the chain polymer effectively increase the modification amount of NH2 -UiO-66 nanoparticles to increase the phase ratio of open tubular capillary column and enhance the interactions with analytes...
March 30, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29595853/phenethyl-isothiocyanate-in-combination-with-dibenzoylmethane-inhibits-the-androgen-independent-growth-of-prostate-cancer-cells
#19
Huarong Huang, Yan He, Lanyue Zhang, Hongping Xiang, Dongli Li, Wenfeng Liu, Xue-Tao Xu, Susan Goodin, Kun Zhang, Xi Zheng
Phenethyl isothiocyanate (PEITC) is a naturally occurring compound found in some cruciferous vegetables. Dibenzoylmethane (DBM) is a minor constituent of licorice. Both compounds have been shown to exert anticancer activities. In the present study, we determined the effects of PEITC and DBM alone or in combination on androgen-independent growth of human prostate cancer cells cultured in vitro and prostate VCaP xenograft tumors in severe combined immunodeficient (SCID) mice. PEITC and DBM in combination had stronger effects on inhibiting the growth and inducing apoptosis than either compound alone in cultured prostate cancer cells...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29558289/therapeutic-potential-of-glycyrrhetinic-acids-a-patent-review-2010-2017
#20
Hidayat Hussain, Ivan R Green, Umair Shamraiz, Muhammad Saleem, Amin Badshah, Ghulam Abbas, Najeeb Ur Rehman, Muhammad Irshad
Glycyrrhetinic acids (GAs) viz., 18β-glycyrrhetinic acid and 18α-glycyrrhetinic acid, are oleanane-type triterpenes having a carboxylic acid group at C-30, and are extracted from the Chines herbal medicine licorice (Glycyrrhiza uralensis). Although the pharmacological properties of GAs have long been known, attention to them has greatly increased in recent times due to their cytotoxic activity. Areas Covered: This review represents the patents granted about natural and synthetic glycyrrhetinic acid analogs from January 2010 to December 2017, the advances made by research groups in conjunction with pharmaceutical companies in the discovery of new natural or synthetic glycyrrhetinic acid analogs...
March 20, 2018: Expert Opinion on Therapeutic Patents
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