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Jing Qiao, Zuliang Luo, Yanpeng Li, Guangxi Ren, Chunsheng Liu, Xiaojun Ma
Licorice is one of the most generally used herbal medicines in the world; however, wild licorice resources have decreased drastically. Cultivated Glycyrrhiza uralensis Fischer are the main source of licorice at present, but the content of main active components in cultivated G. uralensis are lower than in wild G. uralensis. Therefore, the production of high-quality cultivated G. uralensis is an urgent issue for the research and production fields. In this study, the content of five active components and seven endogenous phytohormones in cultivated G...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lingyi Huang, Dejan Nikolic, Richard B van Breemen
The metabolism of the chemoprevention agent licochalcone A, which is a chemopreventive chalcone found in abundance in the licorice species Glycyrrhiza inflata, was investigated using human liver microsomes and human hepatocytes combined with analysis using high performance liquid chromatography-mass spectrometry (LC-MS). Five oxygenated phase I metabolites of licochalcone A were formed by human liver microsomes, including a catechol on the A-ring, two intramolecular cyclization products following epoxidation of the exocyclic alkene at position 5 of the B-ring, and two dioxygenated products...
November 10, 2017: Analytical and Bioanalytical Chemistry
Ping-Hui Lee, Pei-Ming Chu, Pei-Ling Hsieh, Hui-Wen Yang, Pin Ju Chueh, Yu-Feng Huang, Yi-Wen Liao, Cheng-Chia Yu
Oral submucous fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis, and it causes chronic inflammation and persistent activation of myofibroblasts. As yet, existing treatments only provide temporary symptomatic relief and there is a lack of an effective intervention to cure OSF. Therefore, development of approaches to ameliorate myofibroblast activities becomes a crucial objective to prevent the malignant progression of OSF...
November 9, 2017: Environmental Toxicology
Arshi Farooqui, Fahad Khan, Imran Khan, Irfan A Ansari
Cervical cancer is the fourth most common cancer among women worldwide and is a major cause of morbidity and mortality. High-risk Human Papilloma Virus (mostly type 16 & 18) infection is the primary risk factor for the development of cervical carcinoma. The quest for strong, safe and cost effective natural antiproliferative agents that could reduce cervical cancer have been focussed now a day. Recently, glycyrrhizin, a triterpene glycoside (saponin) from licorice (Glycyrrhiza glabra Linn.), has been shown to exhibit potent antiproliferative and anticancer properties in a few preliminary studies...
November 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
M Michelle Reyes, John C Castura, John E Hayes
Temporal Check-All-That-Apply (TCATA) is a rapid method where attributes are actively checked and unchecked to track sensations over time, so that the checked words fully describe the sample in any given moment. Here, we characterize the temporal profiles of sweeteners using TCATA. In two experiments, sweeteners were tested in water at concentrations known to elicit weak to moderate sweetness. Before evaluating the sweeteners, participants (n= ~125 per experiment) were familiarized with the TCATA method with a guided example using imaginary samples of Kool-Aid...
June 2017: Journal of Sensory Studies
Hongke Cai, Xi Chen, Jianbo Zhang, Jijian Wang
18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice root which exerts pharmacological activities including anti-inflammatory, antiviral, anti-oxidative and anti-cancer effects. The current study further investigated the molecular mechanisms associated with the inhibitory effects of 18β-GA on tumor metastasis in human gastric cancer cells. The results indicated that 18β-GA significantly reduced invasion and migration activities and suppressed MMP-2 and 9 activities on SGC-7901cells in a dose-dependent manner...
November 2, 2017: Journal of Natural Medicines
Jing Xiang, Jie-Chang Huang, Chang Xu, Mian He, Peng-Cheng Xu, Dan Zhang, Wen-Feng Zhang, Han Shen, Hong-Wei Shao
MicroRNAs(miRNA) are small non-coding RNAs that regulate the expression of protein coding genes by repressing translation of protein coding mRNA or enhancing mRNA degradation. Its functions have attracted more and more attention from the public. In recent years, the cross-border regulation of miRNA has become a new research direction, and provides a new perspective for people to comprehensively understand the functions of miRNA. Plant miRNA is usually methylated and not easy to degrade. According to our previous researches, there were abundant small RNAs in the decoction of dried liquorice, which provides a new way to study the mechanism of action of licorice...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Hui-Juan Shi, Hong-Bin Song, Le Wang, Sheng-Xiang Xiao, Kai-Ping Bo, Wei Ma
Most traditional Chinese medicine prescription dosages are imprecise. This study analyzes the toxicities and adverse effects of a combination the active ingredients of licorice and Kushen medicine: oxymatrine (OMT) and diammonium glycyrrhizinate (DG). The median lethal dose (LD50) and mortality were analyzed in single-dose OMT (or DG) intraperitoneally injected mice with or without combination DG (or OMT). Body weight changes as well as levels of serum sodium and potassium, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, and urea were measured in mice treated with a daily dose of OMT and/or DG for 14days...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tongchuan Suo, Haixia Wang, Xiaojie Shi, Linlin Feng, Jiayou Cai, Yu Duan, Huimin Bao, Xiaolin Wu, Yue Zhang, Heshui Yu, Zheng Li
Albeit extensively utilized, herb extraction process (HEP) is hard to be monitored because of its batch nature and the fluctuating quality of raw materials. Process analytical tools like near infrared spectroscopy (NIRS) can offer nondestructive examinations and collect abundant data of the process, which in principle contain the information about the quality of both the product and the process itself. However, extra effort is often required for the data mining of such process measurements, and extracting knowledge of the quality of process can be even harder...
October 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
Da Li, Guojie Xu, Guangxi Ren, Yufeng Sun, Ying Huang, Chunsheng Liu
The traditional medicine licorice is the most widely consumed herbal product in the world. Although much research work on studying the changes in the active compounds of licorice has been reported, there are still many areas, such as the dynamic accumulation of secondary metabolites in licorice, that need to be further studied. In this study, the secondary metabolites from licorice under two different methods of stress were investigated by ultra-high-performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS)...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Amina L Mohamed, Ahmed G Hassabo, S Shaarawy, A Hebeish
The research work presented herein was undertaken with a view to develop, characterize and highlight modified cotton fabrics that acquire durable antibacterial activity in concomitant with high metal sorption capacity. The development is based on reacting cotton cellulose previously oxidized by sodium periodate-with 4 amino-1,2,4 triazole in presence and absence of silver nano particles (AgNPs). The idea behind the periodate pretreatment is to convert (via oxidative cleavge) the 2,3-vicinal diol of the anhydroglucose units of cotton into aldehyde groups...
December 15, 2017: Carbohydrate Polymers
Baochao Ji, Wentao Guo, Hairong Ma, Boyong Xu, Wenbo Mu, Zhendong Zhang, Abdusami Amat, Li Cao
Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of the nuclear factor-κB (NF-κB) signaling pathway and anti-inflammatory activity in a wide variety of cells. In the present study, the authors first evaluated the effects of ISL on cartilage degeneration in interleukin-1β (IL-1β)-stimulated chondrocyte-like ATDC5 cells and in a mouse model of osteoarthritis (OA). The data of a cell counting kit-8 and flow cytometry assay indicated that ISL suppressed the inhibitory effect of IL-1β on cell viability...
October 9, 2017: International Journal of Molecular Medicine
Tae-Ho Kang, Goo Yoon, In-A Kang, Ha-Na Oh, Jung-Il Chae, Jung-Hyun Shim
Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti-inflammatory, anti-bacterial, anti-oxidant, and anti-cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines...
October 13, 2017: Phytotherapy Research: PTR
Haiyang Yu, Haiyan Li, Yongxi Li, Min Li, Guanzhi Chen
Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized with high heterogeneity. Recent studies have suggested that it is driven by both terminal keratinocyte differentiation defects and type 2 immune responses. The mainstay steroid topical therapy has severe side effect and new treatment is in demand. Isoliquiritigenin (ISLG) is a small phenolic bioactive molecule from licorice that has shown multiple pharmacological effects against cancer, inflammatory disorder, and cardiovascular diseases...
October 12, 2017: Archives of Dermatological Research
Sang-Ho Kang, Jeong-Hoon Lee, Hyun Oh Lee, Byoung Ohg Ahn, So Youn Won, Seong-Han Sohn, Jung Sun Kim
Glycyrrhiza uralensis and G. glabra, members of the Fabaceae, are medicinally important species that are native to Asia and Europe. Extracts from these plants are widely used as natural sweeteners because of their much greater sweetness than sucrose. In this study, the three complete chloroplast genomes and five 45S nuclear ribosomal (nr)DNA sequences of these two licorice species and an interspecific hybrid are presented. The chloroplast genomes of G. glabra, G. uralensis and G. glabra × G. uralensis were 127,895 bp, 127,716 bp and 127,939 bp, respectively...
October 6, 2017: Genes & Genetic Systems
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
October 5, 2017: Journal of Dietary Supplements
Jin-Jing Xiao, Yang Li, Qing-Kui Fang, Yan-Hong Shi, Min Liao, Xiang-Wei Wu, Ri-Mao Hua, Hai-Qun Cao
The transfer of pesticide residues from herbal teas to their infusion is a subject of particular interest. In this study, a multi-residue analytical method for the determination of pyrethroids (fenpropathrin, beta-cypermethrin, lambda-cyhalothrin, and fenvalerate) in honeysuckle, chrysanthemum, wolfberry, and licorice and their infusion samples was validated. The transfer of pyrethroid residues from tea to infusion was investigated at different water temperatures, tea/water ratios, and infusion intervals/times...
September 30, 2017: International Journal of Environmental Research and Public Health
Yoshihiko Nakatani, Aya Kobe, Megumi Kuriya, Yoko Hiroki, Tadahiro Yahagi, Iwao Sakakibara, Keiichi Matsuzaki, Taku Amano
Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and neuroprotective effects. Among the various compounds in Glycyrrhiza, the active compounds that show biological activity are thought to include glycyrrhizin, glycyrrhetinic acid, glabridin, licochalcones and liquiritin...
November 15, 2017: European Journal of Pharmacology
Dana M Freund, Amanda C Martin, Jerry D Cohen, Adrian D Hegeman
Leaf spray-MS minimizes tissue manipulation by effectively and quickly assessing in vivo specialized metabolites from intact plant tissue surfaces, including trichome metabolites. Intact leaves of Glycyrrhiza lepidota Pursh. (American licorice) were analyzed by direct electrospray leaf spray-MS, an ambient ionization technique. Comparison of metabolites detected by leaf spray-MS to those from LC-MS of bulk tissue and trichome enriched extracts showed dramatic differences. Leaf spray-MS results suggest that in specific situations this approach could complement traditional LC-MS analysis of bulk extracts...
September 27, 2017: Planta
Zhi-Xin Sun, Pan-Pan Zhang, Wu-Lin Gao, Guo-Hua Dai
To analyze the prescription and medication rules of Chinese medicines in the treatment of palpitations in the Chinese journal full text database(CNKI) by using traditional Chinese medicine inheritance system, and provide a reference for further research and development of modern traditional Chinese medicines(TCMs) in treatment of palpitations. In order to give better guidance for clinical mediation, prescriptions used for treatment of palpitations in CNKI were collected, and then were input to the TCM inheritance support system for establishing a Chinese medicine prescription database for palpitations...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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