keyword
MENU ▼
Read by QxMD icon Read
search

licorice

keyword
https://www.readbyqxmd.com/read/28635361/role-of-licochalcone-a-in-vegf-induced-proliferation-of-human-airway-smooth-muscle-cells-implications-for-asthma
#1
Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu
Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) mass. Licochalcone A is the predominant characteristic chalcone in licorice root. We found that licochalcone A inhibited vascular endothelial growth factor (VEGF)-induced ASM cell proliferation and induced cell cycle arrest. Additionally, VEGF-induced ASM cell proliferation was suppressed via inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) activity, but not that of Akt...
February 2017: Growth Factors
https://www.readbyqxmd.com/read/28629539/uplc-esi-qtof-ms-based-metabolomics-survey-on-the-toxicity-of-triptolide-and-detoxication-of-licorice
#2
Zhuo Wang, Jian-Qun Liu, Jin-Di Xu, He Zhu, Ming Kong, Guo-Hua Zhang, Su-Min Duan, Xiu-Yang Li, Guang-Fu Li, Li-Fang Liu, Song-Lin Li
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction (LWE) against such toxicity...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28626475/stereospecific-pharmacokinetic-characterization-of-liquiritigenin-in-the-rat
#3
Samaa Alrushaid, Neal M Davies, Stephanie E Martinez, Casey L Sayre
Liquiritigenin is a chiral flavonoid present in licorice and other medicinal plants. The nature of its biological fate with respect to the individual enantiomers has not been examined. In this study, we characterize, for the first time, the stereoselective pharmacokinetics of liquiritigenin. Liquiritigenin was intravenously (20 mg/kg) and orally (50 mg/kg) administered to male Sprague-Dawley rats (n = 4 per route of administration). Concentrations in serum and urine were characterized via stereospecific reversed-phase, isocratic HPLC method with UV detection...
June 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28624548/glucocorticoids-and-gut-bacteria-the-galf-hypothesis-in-the-metagenomic-era
#4
REVIEW
David J Morris, Jason M Ridlon
A new concept is emerging in biomedical sciences: the gut microbiota is a virtual 'organ' with endocrine function. Here, we explore the literature pertaining to the role of gut microbial metabolism of endogenous adrenocorticosteroids as a contributing factor in the etiology of essential hypertension. A body of literature demonstrates that bacterial products of glucocorticoid metabolism are absorbed into the portal circulation, and pass through the kidney before excretion into urine. Apparent Mineralocorticoid Excess (AME) syndrome patients were found to have congenital mutations resulting in non-functional renal 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) and severe hypertension often lethal in childhood...
June 14, 2017: Steroids
https://www.readbyqxmd.com/read/28617146/diospyros-rhodocalyx-tako-na-a-thai-folk-medicine-associated-with-hypokalemia-and-generalized-muscle-weakness-a-case-series
#5
Rittirak Othong, Satariya Trakulsrichai, Winai Wananukul
INTRODUCTION: Diospyros rhodocalyx (Tako-Na) is a Thai folk medicine purported to promote longevity, treat impotence, etc. We present patients with hypokalemia, weakness and hypertension after consuming Tako-Na tea. CASE SERIES: Case 1: A 61-year-old man was brought in nine hours after drinking 400-500 mL of Tako-Na tea. One handful of Tako-Na bark was boiled in water to make tea. He had vomiting and watery diarrhea six hours after drinking it. He took no medications and had no history of hypertension...
June 15, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28605826/inhibition-of-hazardous-compound-formation-in-muscle-foods-by-antioxidative-phytophenols
#6
REVIEW
Youling L Xiong
Individual and mixed herbal extracts, as well as plant spices, are widely used in the preparation of muscle foods to enhance the organoleptic attributes. Abundantly rich in phenolic compounds, many of the phytochemical extracts have been shown to possess strong radical-scavenging and metal ion-binding properties and hence exert antioxidant activity in meat products. Because of their antiradical nature, phenolic acids and flavonoids, such as tea catechins, caffeic acid, chlorogenic acid, and mixed polyphenols derived from rosemary, licorice, and other herbal materials, are capable of inhibiting the formation of harmful secondary products from oxidized lipids and proteins...
June 12, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28593138/licochalcone-a-specifically-induces-cell-death-in-glioma-stem-cells-via-mitochondrial-dysfunction
#7
Kenta Kuramoto, Shuhei Suzuki, Hirotsugu Sakaki, Hiroyuki Takeda, Tomomi Sanomachi, Shizuka Seino, Yoshitaka Narita, Takamasa Kayama, Chifumi Kitanaka, Masashi Okada
Glioblastoma multiforme is the most malignant primary intrinsic brain tumor. Glioma stem cells (GSCs) are associated with chemoradiotherapy resistance and the recurrence of glioblastomas after conventional therapy. The targeting of GSCs is potentially an effective treatment for the long-term survival of glioblastoma patients. Licochalcone A, a natural chalconoid from licorice root, exerts anticancer effects; however, its effect on GSCs remains unknown. We found that Licochalcone A induced massive caspase-dependent death in GSCs but not in differentiated GSCs nor normal somatic and neural stem cells...
June 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28572827/protective-effect-of-18%C3%AE-glycyrrhetinic-acid-against-triptolide-induced-hepatotoxicity-in-rats
#8
Guanghua Yang, Lan Wang, Xiuting Yu, Yanfeng Huang, Chang Qu, Zhenbiao Zhang, Dandan Luo, Ji Lin, Lian Zhou, Ziren Su, Xiaojun Zhang, Haiming Chen
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity in rats. TP interference markedly elevated serum levels of ALT, AST, and ALP, caused evident liver histopathological changes, and elevated hepatic TNF-α, IL-6, IL-1β, and IFN-γ as well as nuclear translocation of NF-κB...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28560439/isoliquiritigenin-inhibits-the-proliferation-of-human-renal-carcinoma-caki-cells-through-the-ros-mediated-regulation-of-the-jak2-stat3-pathway
#9
Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chun
Isoliquiritigenin (ISL) is a flavonoid with chalcone structure that has been noted in licorice and shallot, which are generally used in traditional Chinese medicine. ISL has demonstrated various pharmacological effects including antioxidant, anti-inflammatory and antitumor activity. However, the molecular mechanisms underlying the anticancer effects of ISL remain poorly understood. The present study revealed that ISL significantly decreased viability and induced apoptosis in human renal carcinoma Caki cells...
May 30, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28552807/glycyrrhizin-inhibits-lps-induced-inflammatory-mediator-production-in-endometrial-epithelial-cells
#10
Xue-Rong Wang, Hong-Guang Hao, Lan Chu
Endometriosis is a continuous inflammation of uterine endometrium that usually affects women of reproductive age. Glycyrrhizin, a triterpene isolated from the roots and rhizomes of licorice (Glycyrrhiza glabra), has been known to have anti-inflammatory effect. The purpose of this study was to investigate the anti-inflammatory effect of glycyrrhizin on LPS-stimulated mouse endometrial epithelial cells (MEEC). The levels of TNF-α, IL-1β, and PGE2 were measured by ELISA. The expression of COX-2, iNOS, TLR4, and NF-ĸB were detected by western blot analysis...
May 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28539738/the-mealiness-and-quality-of-herbal-medicine-licorice-for-example
#11
Xueying Liu, Weilong Hou, Deqiang Dou
BACKGROUND: The morphological identification is an effective and simple quality evaluation method in Chinese drugs, and the traits of mealiness and color were widely used in the commercial market of Chinese drugs. OBJECTIVE: The objective of this study was to explore the correlation between mealiness of herbal drugs and its quality; licorice was selected as an example. MATERIALS AND METHODS: The mealiness of licorice was graded by its weight; meanwhile, the content of glycyrrhizic acid and liquiritin was determined by high-performance liquid chromatography-diode-array detection method; the content of polysaccharides, soluble sugars, pectin, total starch, amylose, and amylopectin was measured by colorimetric method; and the number and diameter of starch granule were observed by microscope...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28531979/synthesis-and-characterization-of-glycyrrhizic-acid-coated-iron-oxide-nanoparticles-for-hyperthermia-applications
#12
Mostafa Saeedi, Omid Vahidi, Shahin Bonakdar
In the present study, iron oxide magnetic nanoparticles (IONPs) were synthesized using the oxidative precipitation method for biomedical applications. Glycyrrhizic acid (GA) extracted from the roots of licorice plant was used as the coating agent for the synthesized nanoparticles (GAIONPs). The crystal phase, morphology and size were investigated by XRD, FE-SEM and TEM. The saturation magnetization (ms) value of the nanoparticles was measured by VSM indicating lowered ms of the GAIONPs with respect to that of the IONPs due to the presence of GA...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28522265/screening-for-bioactive-natural-products-from-a-67-compound-library-of-glycyrrhiza-inflata
#13
Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye
Licorice shows a variety of pharmacological activities. This work aims to discover bioactive natural products from one botanical source of licorice, Glycyrrhiza inflata. A total of 67 free phenolics were isolated to form a compound library. Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T...
May 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28506909/the-selective-effect-of-glycyrrhizin-and-glycyrrhetinic-acid-on-topoisomerase-ii%C3%AE-and-apoptosis-in-combination-with-etoposide-on-triple-negative-breast-cancer-mda-mb-231-cells
#14
Yun Cai, Boxin Zhao, Qianying Liang, Yunqi Zhang, Jieying Cai, Guofeng Li
Triple negative breast cancer(TNBC) has generated growing interests due to its aggressive biologic behavior and absence of targeted therapy approach. Glycyrrhizin(GL) from licorice root and its metabolite, glycyrrhetinic acid(GA) have shown extensive bioactivities in clinic. Here, we demonstrate that GL and GA have contrary anti-cancer effect on TNBC MDA-MB-231 cells. Beside its inhibition of cell proliferation, GA at non-cytotoxic concentration showed synergistic effect in combination with anti-cancer drug, etoposide(VP-16)...
May 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28499205/comparative-metabolomics-analysis-for-the-compatibility-and-incompatibility-of-kansui-and-licorice-with-different-ratios-by-uhplc-qtof-ms-and-multivariate-data-analysis
#15
Juan Shen, Zong-Jin Pu, Jun Kai, An Kang, Yu-Ping Tang, Li-Li Shang, Gui-Sheng Zhou, Zhen-Hua Zhu, Er-Xin Shang, Shao-Ping Li, Yu-Jie Cao, Wei-Wei Tao, Shu-Lan Su, Li Zhang, Huiping Zhou, Da-Wei Qian, Jin-Ao Duan
Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical "eighteen incompatible" medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), and the efficacy could be weakened by the co-use of licorice, even causing serious toxicity at the given ratio. Nevertheless, the actual mechanisms of their dosage-toxicity-efficacy relationship need to be well clarified...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28484719/glycyrrhizin-protects-rats-from-sepsis-by-blocking-hmgb1-signaling
#16
Feng Zhao, Yong Fang, Shuixiang Deng, Xiantao Li, Yun Zhou, Ye Gong, Hechen Zhu, Wei Wang
Background. HMGB1 acts as an important inflammatory mediator and is a potential therapeutic target for sepsis. Glycyrrhizin (GL), a natural triterpene glycoside derived from licorice, has been demonstrated to inhibit HMGB1 activity. The aim of this study is to explore how GL affects the HMGB1 signaling in sepsis. Methods. We used a CLP model of sepsis and in vitro LPS or HMGB1-treated NR8383 cells to examine the effects of GL on expression of HMGB1 and proinflammatory cytokines. Furthermore, we explored the effect of GL on interactions between HMGB1 and RAGE or TLR4 and the activations of NF-κB and MAPKs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28464803/the-repressive-effect-of-mir-148a-on-wnt-%C3%AE-catenin-signaling-involved-in-glabridin-induced-anti-angiogenesis-in-human-breast-cancer-cells
#17
Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li, Zhong Li
BACKGROUND: Glabridin (GLA), a major component extracted from licorice root, has anti-inflammatory and antioxidant activities, but few studies report its mechanism of inhibition of angiogenesis. This study was an extension of our previous work, which demonstrated that GLA suppressed angiogenesis in human breast cancer (MDA-MB-231 and Hs-578T) cells. Breast cancer is one of the most common malignant diseases in females worldwide, and the major cause of mortality is metastasis that is primarily attributed to angiogenesis...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28454311/antitumor-effects-and-the-underlying-mechanism-of-licochalcone-a-combined-with-5-fluorouracil-in-gastric-cancer-cells
#18
Xiaolin Lin, Lei Tian, Lisha Wang, Wenyan Li, Qi Xu, Xiuying Xiao
Licochalcone A (LCA) is a flavonoid extracted from licorice root that has antiparasitic, antibacterial and antitumor properties. Previous studies have revealed that LCA may be a novel treatment for gastric cancer. The present study further assessed the potential antitumor effects of LCA alone or in combination with 5-fluorouracil (5-FU), and the underlying mechanisms responsible for those effects in gastric cancer cells. The effects of LCA alone or in combination with 5-FU on SGC7901 and MKN-45 gastric cancer cell lines were studied using Cell Counting Kit-8, cell cycle, apoptosis and western blot analyses of cell check points and apoptosis-associated proteins...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28447397/an-lc-ms-ms-method-for-determination-of-bioactive-components-of-licorice-and-semen-strychni-in-rat-plasma-application-to-a-pharmacokinetics-study
#19
Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing-Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan
Semen Strychni is known for its treatment of rheumatic arthritis with a low therapeutic index. Licorice contributes a lot in herb detoxification according to the traditional Chinese medicine theory. A simple, rapid and sensitive liquid chromatography-mass spectrometric method was developed and validated for simultaneous determination of main bioactive ingredients in licorice and Semen Strychni in rat plasma. Using moclobemide and cyproterone acetate as the internal standards, the analytes were pretreated via protein precipitation with methanol...
April 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28416456/licoricidin-inhibits-the-growth-of-sw480-human-colorectal-adenocarcinoma-cells-in-vitro-and-in-vivo-by-inducing-cycle-arrest-apoptosis-and-autophagy
#20
Shuai Ji, Shunan Tang, Kai Li, Ziwei Li, Wenfei Liang, Xue Qiao, Qi Wang, Siwang Yu, Min Ye
Licorice (Glycyrrhiza uralensis Fisch.) possesses significant anti-cancer activities, but the active ingredients and underlying mechanisms have not been revealed. By screening the cytotoxic activities of 122 licorice compounds against SW480 human colorectal adenocarcinoma cells, we found that licoricidin (LCD) inhibited SW480 cell viability with an IC50 value of 7.2μM. Further studies indicated that LCD significantly induced G1/S cell cycle arrest and apoptosis in SW480 cells, accompanied by inhibition of cyclins/CDK1 expression and activation of caspase-dependent pro-apoptotic signaling...
July 1, 2017: Toxicology and Applied Pharmacology
keyword
keyword
40375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"