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https://www.readbyqxmd.com/read/28325014/real-time-monitoring-of-swimming-performance
#1
R Delgado-Gonzalo, A Lemkaddem, Ph Renevey, E Muntane Calvo, M Lemay, K Cox, D Ashby, J Willardson, M Bertschi
This article presents the performance results of a novel algorithm for swimming analysis in real-time within a low-power wrist-worn device. The estimated parameters are: lap count, stroke count, time in lap, total swimming time, pace/speed per lap, total swam distance, and swimming efficiency (SWOLF). In addition, several swimming styles are automatically detected. Results were obtained using a database composed of 13 different swimmers spanning 646 laps and 858.78 min of total swam time. The final precision achieved in lap detection ranges between 99...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323415/facile-access-to-multi-sensitive-and-self-healing-hydrogels-with-reversible-and-dynamic-boronic-ester-and-disulfide-linkages
#2
Ruiwei Guo, Qian Su, Jinwei Zhang, Anjie Dong, Cunguo Lin, Jianhua Zhang
Multifunctional and multi-responsive hydrogels have presented a promising platform to design and fabricate smart devices for application in a wide variety of fields. However, their preparations often involve multistep preparation of multi-responsive polymer precursors, tedious reactions to introduce functional groups or sophisticated molecular designs. In this work, a multifunctional boronic acid-based crosslinker bis(phenylboronic acid carbamoyl) cystamine (BPBAC) was readily prepared from inexpensive commercially available 3-carboxylphenylboronic acid (CPBA) and cystamine dihydrochloride, which has the ability to crosslink the cis-diols and catechol-containing hydrophilic polymers to form hydrogels...
March 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28322552/one-step-fabrication-of-a-microfluidic-device-with-an-integrated-membrane-and-embedded-reagents-by-multimaterial-3d-printing
#3
Feng Li, Petr Smejkal, Niall P Macdonald, Rosanne M Guijt, Michael C Breadmore
One of the largest impediments in the development of microfluidic-based smart sensing systems is the manufacturability of integrated, complex devices. Here, we propose multimaterial 3D printing for the fabrication of such devices in a single step. A microfluidic device containing an integrated porous membrane and embedded liquid reagents was made by 3D printing and applied for the analysis of nitrate from soil. The manufacture of the integrated, sealed device was realised as a single print within 30 min. The body of the device was printed in transparent acrylonitrile butadiene styrene (ABS), and contained a 400 μm wide structure printed from a commercially available composite filament...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28302179/balanced-crystalloids-versus-saline-in-the-intensive-care-unit-study-protocol-for-a-cluster-randomized-multiple-crossover-trial
#4
Matthew W Semler, Wesley H Self, Li Wang, Daniel W Byrne, Jonathan P Wanderer, Jesse M Ehrenfeld, Joanna L Stollings, Avinash B Kumar, Antonio Hernandez, Oscar D Guillamondegui, Addison K May, Edward D Siew, Andrew D Shaw, Gordon R Bernard, Todd W Rice
BACKGROUND: Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute kidney injury and death. Whether using balanced crystalloids rather than saline decreases the risk of acute kidney injury and death among critically ill adults remains unknown. METHODS: The Isotonic Solutions and Major Adverse Renal Events Trial (SMART) is a pragmatic, cluster-level allocation, cluster-level crossover trial being conducted between 1 June 2015 and 30 April 2017 in five intensive care units at Vanderbilt University Medical Center in Nashville, TN, USA...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28292300/clinical-outcomes-and-glycaemic-responses-to-different-aerobic-exercise-training-intensities-in-type-ii-diabetes-a-systematic-review-and-meta-analysis
#5
Aimee Grace, Erick Chan, Francesco Giallauria, Petra L Graham, Neil A Smart
AIMS: To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. METHODS: A systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts...
March 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28269434/a-mobile-platform-for-automated-screening-of-asthma-and-chronic-obstructive-pulmonary-disease
#6
Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher
Chronic Obstructive Pulmonary Disease (COPD) and asthma each represent a large proportion of the global disease burden; COPD is the third leading cause of death worldwide and asthma is one of the most prevalent chronic diseases, afflicting over 300 million people. Much of this burden is concentrated in the developing world, where patients lack access to physicians trained in the diagnosis of pulmonary disease. As a result, these patients experience high rates of underdiagnosis and misdiagnosis. To address this need, we present a mobile platform capable of screening for Asthma and COPD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266836/porous-gold-nanoparticles-decorated-nanoreactors-prepared-from-smartly-designed-functional-polystyrene-block-poly-d-l-lactide-diblock-copolymers-towards-efficient-systems-for-catalytic-cascade-reaction-processes
#7
Romain Poupart, Antoine Benlahoues, Benjamin Le Droumaguet, Daniel Grande
Original nanoporous catalytic supports can be engineered via an effective and straightforward synthetic route to polystyrene-block-poly(D,L-lactide) diblock copolymer precursors displaying an acid-cleavable acetal junction between both blocks. To this purpose, an acetal-containing hetero-difunctional initiator was synthesized, thus enabling to combine two different polymerization methods, i.e. first Atom Transfer Radical Polymerization (ATRP) of styrene, and then Ring-Opening Polymerization (ROP) of D,L-lactide...
March 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28266210/reversible-light-switching-of-enzymatic-activity-on-orthogonally-functionalized-polymer-brushes
#8
Matthias Dübner, Victor J Cadarso, Tugce N Gevrek, Amitav Sanyal, Nicholas D Spencer, Celestino Padeste
Copolymer brushes, composed of glycidyl methacrylate and a furan-protected maleimide-containing monomer, were grafted from radical initiators at the surface of irradiation-activated fluoropolymer foils. After postpolymerization modification with enzymatically active microperoxidase-11 and photochromic spiropyran moieties, the polymer brushes catalyzed the oxidation of 3,3'5,5'-tetramethylbenzidine. Exposure to either UV or visible-light allowed switching the turnover by more than 1 order of magnitude, as consequence of the reversible, light-induced spiropyran-merocyanine transition...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28264428/validation-of-a-tablet-application-for-assessing-dietary-intakes-compared-with-the-measured-food-intake-food-waste-method-in-military-personnel-consuming-field-rations
#9
Mavra Ahmed, Iva Mandic, Wendy Lou, Len Goodman, Ira Jacobs, Mary R L'Abbé
The collection of accurate dietary intakes using traditional dietary assessment methods (e.g., food records) from military personnel is challenging due to the demanding physiological and psychological conditions of training or operations. In addition, these methods are burdensome, time consuming, and prone to measurement errors. Adopting smart-phone/tablet technology could overcome some of these barriers. The objective was to assess the validity of a tablet app, modified to contain detailed nutritional composition data, in comparison to a measured food intake/waste method...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28263051/dual-targeted-multifunctional-nanoparticles-for-magnetic-resonance-imaging-guided-cancer-diagnosis-and-therapy
#10
Xueyan Nan, Xiujuan Zhang, Yanqiu Liu, Mengjiao Zhou, Xianfeng Chen, Xiaohong Zhang
Hybrid nanostructures with combined functionalities can be rationally designed to achieve synergistic effects for efficient cancer treatment. Herein, a multifunctional nanoplatform is constructed, containing an inner core of an anticancer drug MTX surrounding by a nanometer-thin layer of gold as the shell with Fe3O4 magnetic nanoparticles (NPs) evenly distributed in the gold layer, and the outermost hybrid LA-PEG-MTX molecules as surface coating agent (denoted as MFG-LPM NPs). This nanocomposite possesses very high drug loading capacity as the entire core is MTX and integrates magnetic- and active- targeting drug delivery, light-controlled drug release, magnetic resonance imaging (MRI), as well as photothermal and chemotherapy...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28262662/epilepsy-and-intellectual-disability-linked-protein-shrm4-interaction-with-gababrs-shapes-inhibitory-neurotransmission
#11
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G Smart, Maria Passafaro
Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GABAB receptors (GABABRs) to control their cell surface expression and intracellular trafficking via a dynein-dependent mechanism. Knockdown of Shrm4 in rat severely impairs GABABR activity causing increased anxiety-like behaviour and susceptibility to seizures...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28259207/polymer-decorated-gold-nanoparticles-in-nanomedicine-conjugates
#12
REVIEW
Ignác Capek
Noble metal, especially gold nanoparticles and their conjugates with biopolymers have immense potential for disease diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of noble metal nanoparticles to ligands specifically targeted to biomarkers on diseased cells allows molecular-specific imaging and detection of disease. The development of smart gold nanoparticles (AuNPs) that can deliver therapeutics at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating cancer tumors...
February 15, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28257160/increasing-the-protein-quantity-in-a-meal-results-in-dose-dependent-effects-on-postprandial-glucose-levels-in-individuals-with-type-1-diabetes-mellitus
#13
M A Paterson, C E M Smart, P E Lopez, P Howley, P McElduff, J Attia, C Morbey, B R King
AIM: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. METHODS: Participants with Type 1 diabetes [aged 10-40 years, HbA1c ≤ 64 mmol/mol (8%), BMI ≤ 91(st) percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12...
March 3, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28256700/clinical-relevance-of-antimicrobial-testing-results-for-dental-restorative-materials
#14
Cher Farrugia, Julie Haider, Liberato Camilleri, Josette Camilleri
BACKGROUND: The antimicrobial activity of restorative materials is clinically relevant because all dental materials are subject to an environment containing bacteria. This study aimed to investigate the use of 2 methodologies referred to in the literature to assess antimicrobial properties of restorative materials and investigate whether material properties alter results of these traditional methodologies. METHODS: A number of dental restorative materials - namely, Chemfil Superior®, Spectrum®, Heliobond®, Ionoseal®, Dyract Extra®, Smart Dentin Replacement (SDR®) and Biodentine® - were characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR) spectroscopy and pH analysis...
February 28, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28251706/electrochromism-and-nonvolatile-memory-device-derived-from-triphenylamine-based-polyimides-with-pendant-viologen-units
#15
Hung-Ju Yen, Chia-Liang Tsai, Shih-Han Chen, Guey-Sheng Liou
Three novel solution-processable polyimides containing triphenylamine and pendant viologen moieties are prepared from the newly synthesized diamine and three commercially available dianhydrides. The thermally stable polyimide with strong donor-acceptor charge-transfer possesses write-once read-many-times memory behavior with excellent operation stability. The obtained multicolored electrochromic polymer films reveal ambipolar electrochemical behavior with high optical transmittance contrast of coloration changed from transmissive neutral state to the cyan/magenta/yellow redox states, implying great potential for application in smart window and displays...
March 2, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28242418/revisiting-structure-property-relationship-of-ph-responsive-polymers-for-drug-delivery-applications
#16
REVIEW
Salime Bazban-Shotorbani, Mohammad Mahdi Hasani-Sadrabadi, Akbar Karkhaneh, Vahid Serpooshan, Karl I Jacob, Alireza Moshaverinia, Morteza Mahmoudi
pH-responsive polymers contain ionic functional groups as pendants in their structure. The total number of charged groups on polymer chains determines the overall response of the system to changes in the external pH. This article reviews various pH-responsive polymers classified as polyacids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharides, and anionic polypeptides) and polybases (e.g., polyamines, pyridine and imidazole containing polymers, cationic polysaccharides, and cationic polypeptides)...
February 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28239609/application-of-taxonomic-modeling-to-microbiota-data-mining-for-detection-of-helminth-infection-in-global-populations
#17
Mahbaneh Eshaghzadeh Torbati, Makedonka Mitreva, Vanathi Gopalakrishnan
Human microbiome data from genomic sequencing technologies is fast accumulating, giving us insights into bacterial taxa that contribute to health and disease. The predictive modeling of such microbiota count data for the classification of human infection from parasitic worms, such as helminths, can help in the detection and management across global populations. Real-world datasets of microbiome experiments are typically sparse, containing hundreds of measurements for bacterial species, of which only a few are detected in the bio-specimens that are analyzed...
December 2016: Data (Basel)
https://www.readbyqxmd.com/read/28227680/a-mobile-platform-for-automated-screening-of-asthma-and-chronic-obstructive-pulmonary-disease
#18
Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Richard Ribon Fletcher, Rahul Kodgule
Chronic Obstructive Pulmonary Disease (COPD) and asthma each represent a large proportion of the global disease burden; COPD is the third leading cause of death worldwide and asthma is one of the most prevalent chronic diseases, afflicting over 300 million people. Much of this burden is concentrated in the developing world, where patients lack access to physicians trained in the diagnosis of pulmonary disease. As a result, these patients experience high rates of underdiagnosis and misdiagnosis. To address this need, we present a mobile platform capable of screening for Asthma and COPD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227572/real-time-monitoring-of-swimming-performance
#19
R Delgado-Gonzalo, A Lemkaddem, Ph Renevey, E Muntane Calvo, M Lemay, K Cox, D Ashby, J Willardson, M Bertschi, R Delgado-Gonzalo, A Lemkaddem, Ph Renevey, E Muntane Calvo, M Lemay, K Cox, D Ashby, J Willardson, M Bertschi, M Lemay, A Lemkaddem, Ph Renevey, D Ashby, M Bertschi, E Muntane Calvo, J Willardson, R Delgado-Gonzalo, K Cox
This article presents the performance results of a novel algorithm for swimming analysis in real-time within a low-power wrist-worn device. The estimated parameters are: lap count, stroke count, time in lap, total swimming time, pace/speed per lap, total swam distance, and swimming efficiency (SWOLF). In addition, several swimming styles are automatically detected. Results were obtained using a database composed of 13 different swimmers spanning 646 laps and 858.78 min of total swam time. The final precision achieved in lap detection ranges between 99...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217830/relationship-between-alcohol-metabolism-and-chemotherapy-induced-emetic-events-in-breast-cancer-patients
#20
Toshitaka Uomori, Yoshiya Horimoto, Kaoru Mogushi, Joe Matsuoka, Mitsue Saito
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) can negatively affect quality of life and treatment compliance in breast cancer patients. Habitual alcohol consumption reportedly shows an inverse correlation with CINV, though the underlying mechanism is unknown. Acetaldehyde dehydrogenase 2 (ALDH2), one of the two ALDH isozymes, is reportedly the major factor among several genetic polymorphisms possibly affecting alcohol metabolism. More than 40% of Japanese have ALDH2 mutations, while almost all Westerners have the wild type...
February 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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