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Smart containers

Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
Zuyuan Luo, Siqi Zhang, Jijia Pan, Rui Shi, Hao Liu, Yalin Lyu, Xiao Han, Yan Li, Yue Yang, Zhixiu Xu, Yi Sui, En Luo, Yuanyuan Zhang, Shicheng Wei
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanism of the natural extracellular matrix modulating tissue formation, is attractive for enhancing cell activity and controlling cell fate. Here, a bone forming peptide-1 (BFP-1)-laden mesoporous silica nanoparticles (pep@MSNs) incorporated adhesion peptide, containing the arginine-glycine-aspartic acid (RGD) domain, modified alginate hydrogel (RA) system (pep@MSNs-RA) was developed to promote the activity and stimulate osteo-differentiation of human mesenchymal stem cells (hMSCs) in sequence...
February 10, 2018: Biomaterials
Xiaowen Xu, Lei Wang, Kan Li, Qihong Huang, Wei Jiang
Reliable and accurate detection of telomerase activity is crucial for better understanding its role in cancer cells and further exploring its function in cancer diagnosis and treatment. Here, we construct a smart DNA tweezer (DT) for detection of telomerase activity. The DT is assembled by three specially-designed single-stranded oligonucleotides: a central strand dually-labeled with donor/acceptor fluorophores and two arm strands containing overhangs complementary to telomerase reaction products (TRPs). It can get closed through hybridization with TRPs and get reopen through strand displacement reaction by TRPs' complementary sequences...
February 15, 2018: Analytical Chemistry
Yanhui Song, Susheng Zhou, Kaiyun Jin, Jian Qiao, Da Li, Chao Xu, Dongmei Hu, Jiangtao Di, Min Li, Zuoguang Zhang, Qingwen Li
Hybrid smart actuators fabricated using composites of carbon fibers and shape memory polymers have been extensively studied in recent years. However, relatively slow shape recovery has combined with the reset of shape deformation during cycles to restrict their practical use. An electrothermally reversible actuator based on carbon nanotube (CNT) composite yarn containing CNT fiber and thermoplastic polyurethane (TPU) resin with excellent shape memory was investigated in this paper. The combination of CNT yarn and TPU resin considerably amplified the contraction and stability...
February 12, 2018: Nanoscale
Rajeet Chandan, Rinti Banerjee
Recently, liposomes-microbubble conjugates have emerged as a promising ultrasound (US)-responsive platform for cancer therapeutics. However, these are limited by their size in terms of tumor penetration. Additionally, there have been no attempts to enhance the smartness of such conjugates which have been used only as passive carriers. The present study explores submicron sized (756 ± 180.0 nm), US-responsive, phosphatidylserine (PS)-based paclitaxel-liposomes-nanobubble conjugates (PSPLBC) with an additional pro-apoptotic effect towards enhanced anti-cancer efficacy and image-guidance...
February 8, 2018: Scientific Reports
Amale Ankhili, Xuyuan Tao, Cédric Cochrane, David Coulon, Vladan Koncar
A medical quality electrocardiogram (ECG) signal is necessary for permanent monitoring, and an accurate heart examination can be obtained from instrumented underwear only if it is equipped with high-quality, flexible, textile-based electrodes guaranteeing low contact resistance with the skin. The main objective of this article is to develop reliable and washable ECG monitoring underwear able to record and wirelessly send an ECG signal in real time to a smart phone and further to a cloud. The article focuses on textile electrode design and production guaranteeing optimal contact impedance...
February 7, 2018: Materials
Marta Bartel, Barbara Wysocka, Pamela Krug, Daria Kępińska, Krystyna Kijewska, Gary J Blanchard, Katarzyna Kaczyńska, Katarzyna Lubelska, Katarzyna Wiktorska, Paulina Głowala, Marcin Wilczek, Marcin Pisarek, Jacek Szczytko, Andrzej Twardowski, Maciej Mazur
Fabrication of multifunctional smart vehicles for drug delivery is a fascinating challenge of multidisciplinary research at the crossroads of materials science, physics and biology. We demonstrate a prototypical microcapsule system that is capable of encapsulating hydrophobic molecules and at the same time reveals magnetic properties. The microcapsules are prepared using a templated synthesis approach where the molecules to be encapsulated (Nile Red) are present in the organic droplets that are suspended in the polymerization solution which also contains magnetic nanoparticles...
January 29, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Tomas Duminis, Saroash Shahid, Natalia G Karpukhina, Robert G Hill
OBJECTIVE: Dental restoration aesthetics, particularly the translucency of modern dental restorative filling materials depends on the refractive index (RI) match between the different components in the material. In the case of dental composites (DC), the RI of the polymer must match the RI of the filler otherwise the material is optically opaque and has limited depth of cure. In the case of glass ionomer cements (GICs), the RI of the ion-leachable glass must match the RI of the polysalts to engineer a smart material with a tooth-like appearance...
February 2, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Xiao Kuang, Kaijuan Chen, Conner K Dunn, Jiangtao Wu, Vincent C F Li, H Jerry Qi
3D printing of flexible and stretchable materials with smart functions such as shape memory and self-healing is highly desirable for the development of future 4D printing technology for myriad applications, such as soft actuators, deployable smart medical devices, and flexible electronics. Here, we report a novel ink that can be used for 3D printing of highly stretchable, shape memory and self-healing elastomer via UV light assisted direct-ink-write (DIW) printing. An ink containing urethane diacrylate and a linear semi-crystalline polymer is developed for 3D printing of a semi-interpenetrating polymer network (semi-IPN) elastomer that can be stretched by up to 600%...
February 5, 2018: ACS Applied Materials & Interfaces
Xubo Zhao, Zhihong Wei, Zhipeng Zhao, Yalei Miao, Yudian Qiu, Wenjing Yang, Xu Jia, Zhongyi Liu, Hongwei Hou
A novel graphene oxide nanoparticle (GON)-based drug delivery system containing GONs as carriers of anticancer drugs and chitosan/dimethylmaleic anhydride-modified chitosan (CS/CS-DMMA) as surface charge-reversible shells is fabricated via the classic self-assembly of the deprotonated carboxyl of GONs and the protonated amine of the CS backbone by electrostatic interaction, and CS-DMMA serves as the outmost layer. In this GON-based drug delivery system, the GON cores as desired carriers might adsorb doxorubicin hydrochloride (DOX) via the π-π stacking interaction between the large π conjugated structures of GO and the aromatic structure of DOX...
February 7, 2018: ACS Applied Materials & Interfaces
L Cornara, A P Fortuna-Perez, I Bruni, A Salis, G Damonte, B Borghesi, M Clericuzio
Dried herbal preparations, based on "Zornia latifolia," are commonly sold on web, mainly for their supposed hallucinogenic properties. In this work, we demonstrate that these commercial products contain a different Fabacea, i.e., Stylosanthes guianensis, a cheaper plant, widely cultivated in tropical regions as a fodder legume. We were provided with plant samples of true Zornia latifolia from Brazil, and carried out a thorough comparison of the two species. The assignment of commercial samples was performed by means of micro-morphological analysis, DNA barcoding, and partial phytochemical investigation...
January 23, 2018: International Journal of Legal Medicine
Wasfy M Obeidat, Shadi F Gharaibeh, Abdolelah A Jaradat
The objective of this study was to evaluate the suitability of a novel matrix tablet formulation made of ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to sustain the release of a weakly basic drug Metronidazole. Recent patents on Metronidazole controlled/sustained release matrices include US7790755, US8784885, US8628797 and US7476403. Matrix tablets formulations were prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating paddle apparatus at paddle speed of 50 rpm, and dissolution medium temperature at 37°C using three different consecutive stages (pH 1...
January 23, 2018: Recent Patents on Drug Delivery & Formulation
Yongmin Zhang, Lian Liu, Xuefeng Liu, Yun Fang
Multi-responsive wormlike micelles (WLMs) remains a significant challenge in the construction of smart soft materials based on surfactants. Herein, we report the preparation of a viscoelastic wormlike micellar solution based on a new redox-responsive surfactant, sodium dodecylselanylpropyl sulfate (SDSePS), and commercially available benzyl tertiary amine (BTA) in the presence of CO2. In this system, the SDSePS can be reversibly switched on (selenide) and off (selenoxide) by a redox reaction, akin to that previously reported for benzylselanyl- or phenylselanyl- surfactants...
January 22, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Valérie C Pierre, Sarah M Harris, Sylvie L Pailloux
Magnetic resonance imaging (MRI) has emerged over the years as one of the preferred modalities for medical diagnostic and biomedical research. It has the advantage over other imaging modalities such as positron emission tomography and X-ray of affording high resolution three-dimensional images of the body without using harmful radiation. The use of contrast agents has further expanded this technique by increasing the contrast between regions where they accumulate and background tissues. As MRI most often measures the relaxation rate of water throughout the body, contrast agents function by modulating the intensity of the water signal either via improved relaxation or via saturation transfer to selected exchangeable proton...
January 22, 2018: Accounts of Chemical Research
Raheleh Ravanfar, Giovana Bonat Celli, Alireza Abbaspourrad
We design a natural and simple core-shell structured microcapsule, which releases the cargo only when exposed to lipase. The cargo is entrapped inside a gel matrix, which is surrounded by a double layer shell containing an inner solid lipid layer and an outer polymer layer. This outer polymer layer can be designed according to the intended biological system and is responsible for protecting the microcapsule architecture and transporting the cargo to the desired site of action. The lipid layer contains natural ester bonds, which are digested by lipase and control the release of cargo from the microcapsule core...
January 22, 2018: ACS Applied Materials & Interfaces
Sabrina Belbekhouche, Saddam Charaabi, Luc Picton, Didier Le Cerf, Benjamin Carbonnier
Novel chemical stimulus-responsive multilayer assemblies have been elaborated through the layer-by-layer deposition of oppositely charged polysaccharides on either flat or spherical surfaces. Concentration-dependent glucose responsiveness was obtained through chemical modification of alginate, selected as polyanion, with phenylboronic acid moieties. QCM measurements showed that the alginate derivate still self-assembles though electrostatically-driven interactions with chitosan at pH 4, and that the polysaccharides multilayer assemblies, as obtained after crosslinking, exhibit improved stability versus pH (in the range 4-9) as well as swelling ability in the presence of glucose-containing solution...
March 15, 2018: Carbohydrate Polymers
Jeff K Caird, Sarah M Simmons, Katelyn Wiley, Kate A Johnston, William J Horrey
Objective An up-to-date meta-analysis of experimental research on talking and driving is needed to provide a comprehensive, empirical, and credible basis for policy, legislation, countermeasures, and future research. Background The effects of cell, mobile, and smart phone use on driving safety continues to be a contentious societal issue. Method All available studies that measured the effects of cell phone use on driving were identified through a variety of search methods and databases. A total of 93 studies containing 106 experiments met the inclusion criteria...
February 2018: Human Factors
Matthew Smart, Aruna Rajagopal, Wing-Ki Liu, Bae-Yeun Ha
The permeability of the bacterial outer membrane, enclosing Gram-negative bacteria, depends on the interactions of the outer, lipopolysaccharide (LPS) layer, with surrounding ions and molecules. We present a coarse-grained model for describing how cationic amphiphilic molecules (e.g., antimicrobial peptides) interact with and perturb the LPS layer in a biologically relevant medium, containing monovalent and divalent salt ions (e.g., Mg^{2+}). In our approach, peptide binding is driven by electrostatic and hydrophobic interactions and is assumed to expand the LPS layer, eventually priming it for disruption...
October 2017: Physical Review. E
Xiongfei Luo, Zhijun Chen, Shujun Li, Shou-Xin Liu, Jian Li
Corrosion of iron-containing materials, which presents serious economic and safety problems, normally begins with micro corrosion. If micro corrosion could be detected and repaired immediately, corrosion damage could be greatly reduced. Current technology and materials, however, are not able to detect micro corrosion of iron in a cheap and convenient manner. Here, we have used a natural product, ellagic acid (EA), to fabricate an EA-functionalized polyvinyl alcohol(PVA) film (EAF) for in-situ sensing of the initial stage of micro corrosion...
January 17, 2018: ACS Applied Materials & Interfaces
Yuxue Ding, Jiaxun Wan, Zihao Zhang, Fang Wang, Jia Guo, Changchun Wang
The anticancer therapy on basis of reactive oxygen species (ROS)-mediated cellular apoptosis has achieved great progress. However, this kind of theraputic strategy still faces some challenges such as light, photosensitizer and oxygen (O2) dependence. In this article, a ROS-mediated anticancer therapy independent of light, photosensitizer and oxygen was established based on a Fe2+-induced ROS-generating nano-system. First, artemisinin (ART) was loaded in porous magnetic supraparticles (MSP) by a nano-deposition method...
January 16, 2018: ACS Applied Materials & Interfaces
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