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https://www.readbyqxmd.com/read/28097872/a-dual-responsive-bola-type-supra-amphiphile-constructed-from-water-soluble-pillar-5-arene-and-naphthalimide-containing-amphiphile-for-intracellular-drug-delivery
#1
Xin Liu, Keke Jia, Yichen Wang, Wei Shao, Chenhao Yao, Luming Peng, Dongmei Zhang, Xiao-Yu Hu, Leyong Wang
Supramolecular construction of multi-stimuli platform for drug delivery is a challenging task. In this work, a pH and GSH (glutathione) dual-responsive bola-type supramolecular amphiphile was successfully fabricated by the complexation between a water-soluble pillar[5]arene (WP5) and a bolaform naphthalimide guest (G) in water. The resulting bola-type amphiphile further self-assembled into supramolecular binary vesicles, which could be disassembled by low pH and/or high GSH concentration environment. Furthermore, the results of drug loading and releasing tests showed that doxorubicin (DOX), the hydrophobic anticancer drug, could be successfully encapsulated into the Stern region of the obtained supramolecular vesicles and generated the DOX-loaded vesicles with good drug-loading efficiency...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28090593/ultralm-and-minilm-locator-tools-for-smart-tracking-of-fluorescent-cells-in-correlative-light-and-electron-microscopy
#2
Elisabeth Brama, Christopher J Peddie, Gary Wilkes, Yan Gu, Lucy M Collinson, Martin L Jones
In-resin fluorescence (IRF) protocols preserve fluorescent proteins in resin-embedded cells and tissues for correlative light and electron microscopy, aiding interpretation of macromolecular function within the complex cellular landscape. Dual-contrast IRF samples can be imaged in separate fluorescence and electron microscopes, or in dual-modality integrated microscopes for high resolution correlation of fluorophore to organelle. IRF samples also offer a unique opportunity to automate correlative imaging workflows...
December 13, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28079384/hypoxia-and-h2o2-dual-sensitive-vesicles-for-enhanced-glucose-responsive-insulin-delivery
#3
Jicheng Yu, Chenggen Qian, Yuqi Zhang, Zheng Cui, Yong Zhu, Qundong Shen, Frances S Ligler, John B Buse, Zhen Gu
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme...
January 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28029761/switchable-photonic-crystals-using-one-dimensional-confined-liquid-crystals-for-photonic-device-application
#4
Seong Ho Ryu, Min-Jun Gim, Wonsuk Lee, Suk-Won Choi, Dong Ki Yoon
Photonic crystals (PCs) have recently attracted considerable attention, with much effort devoted to photonic bandgap (PBG) control for varying the reflected color. Here, fabrication of a modulated one-dimensional (1D) anodic aluminum oxide (AAO) PC with a periodic porous structure is reported. The PBG of the fabricated PC can be reversibly changed by switching the ultraviolet (UV) light on/off. The AAO nanopores contain a mixture of photoresponsive liquid crystals (LCs) with irradiation-activated cis/trans photoisomerizable azobenzene...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28011995/delivery-of-foreign-cytotoxic-t-lymphocyte-epitopes-to-tumor-tissues-for-effective-antitumor-immunotherapy-against-pre-established-solid-tumors-in-mice
#5
Herbert W Kavunja, Shuyao Lang, Suttipun Sungsuwan, Zhaojun Yin, Xuefei Huang
Cytotoxic T lymphocyte (CTL) can have remarkable abilities to kill tumor cells. However, the establishment of successful CTL-based anticancer therapy has met with many challenges. Within tumor cells, there exist subpopulations with low or no expression of the targeted antigen (termed as antigen-loss variants). In addition, tumor cells can downregulate the levels of major histocompatibility complex class I (MHC-I) molecules on cell surface due to immune pressure. As a result, some tumor cells can escape the immune pressure bestowed by CTLs, resulting in treatment failure...
December 23, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27998111/carbon-dot-coated-alginate-beads-as-a-smart-stimuli-responsive-drug-delivery-system
#6
Sristi Majumdar, Gargee Krishnatreya, Neelam Gogoi, Debajit Thakur, Devasish Chowdhury
In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target. A greater amount of MRSA in the system will lead to more release of drug and vice versa. Carbon-dot-coated novel alginate beads (CA-CD) exhibiting superior stability was successfully used as smart drug delivery vehicle. Garlic extract (GE), which contains allicin, was taken as model drug system to demonstrate the phenomena. It was observed that GE loading was 19 and 78% with CA and CA-CD, respectively...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27996002/tunable-molecular-separation-by-nanoporous-membranes
#7
Zhengbang Wang, Alexander Knebel, Sylvain Grosjean, Danny Wagner, Stefan Bräse, Christof Wöll, Jürgen Caro, Lars Heinke
Metal-organic frameworks offer tremendous potential for efficient separation of molecular mixtures. Different pore sizes and suitable functionalizations of the framework allow for an adjustment of the static selectivity. Here we report membranes which offer dynamic control of the selectivity by remote signals, thus enabling a continuous adjustment of the permeate flux. This is realized by assembling linkers containing photoresponsive azobenzene-side-groups into monolithic, crystalline membranes of metal-organic frameworks...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27986812/barbiturates-bind-in-the-glic-ion-channel-pore-and-cause-inhibition-by-stabilizing-a-closed-state
#8
Zaineb Fourati, Reinis Reinholds Ruza, Duncan Laverty, Emmanuelle Drège, Sandrine Delarue-Cochin, Delphine Joseph, Patrice Koehl, Trevor Smart, Marc Delarue
Barbiturates induce anesthesia by modulating the activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs). Despite more than a century of use in clinical practice, the prototypic binding site for this class of drugs within pLGICs is yet to be described. In this study, we present the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC with excellent structural homology to other relevant channels sensitive to general anesthetics and, as shown here, to barbiturates, at clinically-relevant concentrations...
December 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27979747/dna-vaccination-for-cervical-cancer-a-novel-technology-platform-of-rala-mediated-gene-delivery-via-polymeric-microneedles
#9
A A Ali, C M McCrudden, J McCaffrey, J W McBride, G Cole, N J Dunne, T Robson, A Kissenpfennig, R F Donnelly, H O McCarthy
HPV subtypes (16, 18) are associated with the development of cervical cancer, with oncoproteins E6 and E7 responsible for pathogenesis. The goal of this study was to evaluate our 'smart system' technology platform for DNA vaccination against cervical cancer. The vaccination platform brings together two main components; a peptide RALA which condenses DNA into cationic nanoparticles (NPs), and a polymeric polyvinylpyrrolidone (PVP) microneedle (MN) patch for cutaneous delivery of the loaded NPs. RALA condensed E6/E7 DNA into NPs not exceeding 100nm in diameter, and afforded the DNA protection from degradation in PVP...
December 12, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27966641/resilin-microjoints-a-smart-design-strategy-to-avoid-failure-in-dragonfly-wings
#10
H Rajabi, A Shafiei, A Darvizeh, S N Gorb
Dragonflies are fast and manoeuvrable fliers and this ability is reflected in their unique wing morphology. Due to the specific lightweight structure, with the crossing veins joined by rubber-like resilin patches, wings possess strong deformability but can resist high forces and large deformations during aerial collisions. The computational results demonstrate the strong influence of resilin-containing vein joints on the stress distribution within the wing. The presence of flexible resilin in the contact region of the veins prevents excessive bending of the cross veins and significantly reduces the stress concentration in the joint...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27958755/amphiphilic-ferrocene-containing-peg-block-copolymers-as-micellar-nanocarriers-and-smart-surfactants
#11
Arda Alkan, Sarah Wald, Benoit Louage, Bruno G De Geest, Katharina Landfester, Frederik R Wurm
An important and usually the only function of most surfactants in heterophase systems is stabilizing one phase in another, for example, droplets or particles in water. Surfactants with additional chemical or physical handles are promising in controlling the colloidal properties by external stimuli. The redox stimulus is an attractive feature; however, to date only a few ionic redox-responsive surfactants have been reported. Herein, the first nonionic and noncytotoxic ferrocene-containing block copolymers are prepared, carrying a hydrophilic poly(ethylene glycol) (PEG) chain and multiple ferrocenes in the hydrophobic segment...
December 29, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27936939/a-study-of-the-internal-construct-and-predictive-validity-of-the-smart-assessment-for-emergence-from-vegetative-state
#12
A Tennant, H Gill-Thwaites
OBJECTIVE: The Sensory Modality Assessment and Rehabilitation Technique (SMART) was developed to assess the levels of awareness, functional, sensory and communicative abilities of adults in vegetative (VS) or minimally-conscious states following severe brain injury. The current study seeks to ascertain if a total score can be derived from the individual assessments contained within SMART and to test the internal construct and predictive validity of that total score. SUBJECTS: Persons in VS were recruited over a 3-year period and current status was determined after a 17-year follow-up...
December 12, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27935003/a-temperature-ph-and-sugar-triple-stimuli-responsive-nanofluidic-diode
#13
Yu-Bin Zheng, Shuang Zhao, Shuo-Hui Cao, Sheng-Lin Cai, Xiu-Hong Cai, Yao-Qun Li
In this article, we have demonstrated for the first time a triple stimuli-responsive nanofluidic diode that can rectify ionic current under multiple external stimuli including temperature, pH, and sugar. This diode was fabricated by immobilizing poly[2-(dimethylamino)ethyl methacrylate]-co-[4-vinyl phenylboronic acid] (P(DMAEMA-co-VPBA)) onto the wall of a single glass conical nanopore channel via surface-initiator atom transfer radical polymerization (SI-ATRP). The copolymer brushes contain functional groups sensitive to pH, temperature and sugar that can induce charge and configuration change to affect the status of the pore wall...
January 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/27934402/solid-state-27-al-nmr-spectroscopy-of-the-%C3%AE-al13-keggin-containing-al-coordinated-by-a-terminal-hydroxyl-ligand
#14
Brian L Phillips, C André Ohlin, John Vaughn, William Woerner, Scott Smart, Ravi Subramanyam, Long Pan
We report solid-state (27)Al NMR spectroscopic results for the sulfate salt of the γ-Al13 Keggin cluster, γ-[AlO4Al12(OH)25(OH2)11][SO4]3·[H2O]14, that provide a spectroscopic signature for partial hydrolysis of this Keggin-type cluster. In (27)Al multiple-quantum magic-angle spinning NMR spectra, all 13 Al positions of the cluster are at least partially resolved and assigned with the aid of density functional theory (DFT) calculations of the (27)Al electric field gradients. The isotropic chemical shift of the single tetrahedral site, 75...
December 5, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27934188/nanostructured-montmorillonite-clay-for-controlling-the-lipase-mediated-digestion-of-medium-chain-triglycerides
#15
Tahnee J Dening, Paul Joyce, Shasha Rao, Nicky Thomas, Clive A Prestidge
Biocompatible lipid hybrid particles composed of montmorillonite and medium chain triglycerides were engineered for the first time by spray drying oil-in-water emulsions stabilized by montmorillonite platelets to form montmorillonite-lipid hybrid (MLH) microparticles containing up to 75% w/w lipid. In vitro lipolysis studies under simulated intestinal conditions indicated that the specific porous nanoarchitecture and surface chemistry of MLH particles significantly increased the rate (>10-fold) and extent of lipase-mediated digestion compared to that of coarse and homogenized submicrometer triglyceride emulsions...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27924155/versatile-ph-response-micelles-with-high-cell-penetrating-helical-diblock-copolymers-for-photoacoustic-imaging-guided-synergistic-chemo-photothermal-therapy
#16
Shengyu Shi, Yajing Liu, Yu Chen, Zhihuang Zhang, Yunsheng Ding, Zongquan Wu, Jun Yin, Liming Nie
With high optical absorption efficiency, near infrared (NIR) dyes have been proposed as theranostic agents for fluorescence imaging, photoacoustic imaging (PAI), and photothermal therapy (PTT). However, inherent hydrophobicity and short circulation time of small molecule hinder the further biomedical application. Herein smart amphiphilic copolymer was synthesized containing IR780/camptothecin@poly(ε-caprolactone) (IR780/CPT@PCL) as core, helical poly(phenyl isocyanide) (PPI) blocks as shell with the pH-responsive rhodamine B (RhB) moieties in the core-shell interface...
2016: Theranostics
https://www.readbyqxmd.com/read/27917489/nutrition-quality-of-us-school-snack-foods-a-first-look-at-2011-2014-bid-records-in-8-school-districts
#17
Y Claire Wang, Amber Hsiao, Peter Chamberlin, McKenzie Largay, Abbie Archibald, Andrew Malone, JoAnn Stevelos
BACKGROUND: As part of the Healthy, Hunger-Free Kids Act, snacks, and desserts sold in K-12 schools as of the 2014-2015 school year are required to meet the "Smart Snacks" nutritional guidelines. Although studies exist in tracking progress in local and national efforts, the proportion of snack food procured by school districts compliant with the Smart Snacks standard prior to its full implementation is unknown. METHODS: We repurposed a previously untapped database, Interflex, of public bid records to examine the nutritional quality of snacks and desserts procured by school districts...
January 2017: Journal of School Health
https://www.readbyqxmd.com/read/27917020/recent-approaches-in-designing-bioadhesive-materials-inspired-by-mussel-adhesive-protein
#18
REVIEW
Pegah Kord Forooshani, Bruce P Lee
Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhesion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized polymers...
January 1, 2017: Journal of Polymer Science. Part A, Polymer Chemistry
https://www.readbyqxmd.com/read/27905818/predictors-of-sleep-quality-among-young-adults-in-korea-gender-differences
#19
Ae Kyung Chang, Jinyi Choi
This study was performed to identify the factors influencing gender differences in sleep quality between men and women. A cross-sectional survey was conducted using a convenience sample of 300 young adults from three Korean universities. Participants were 20-40 years of age, used smartphones, and took no sleep medication. Participants completed questionnaires on sleep quality, exercise, stress, depression, and smart phone addiction. The predictors of sleep quality in men were coffee consumption, napping, depression, failure to engage in light exercise at least three times per week, being overweight, being in the potential smart phone addiction group, and being employed, which explained 30...
December 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27902728/a-smart-capsule-system-for-automated-detection-of-intestinal-bleeding-using-hsl-color-recognition
#20
Panpan Qiao, Hongying Liu, Xueping Yan, Ziru Jia, Xitian Pi
There are no ideal means for the diagnosis of intestinal bleeding diseases as of now, particularly in the small intestine. This study investigated an intelligent intestinal bleeding detection capsule system based on color recognition. After the capsule is swallowed, the bleeding detection module (containing a color-sensitive adsorptive film that changes color when absorbing intestinal juice,) is used to identify intestinal bleeding features. A hue-saturation-light color space method can be applied to detect bleeding according to the range of H and S values of the film color...
2016: PloS One
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