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https://www.readbyqxmd.com/read/28440649/asymmetric-synthesis-of-trisubstituted-tetrahydrothiophenes-via-in-situ-generated-chiral-fluoride-catalyzed-cascade-sulfa-michael-aldol-reaction-of-1-4-dithiane-2-5-diol-and-%C3%AE-%C3%AE-unsaturated-ketones
#1
Mengying Duan, Yidong Liu, Jun Ao, Lu Xue, Shilong Luo, Yu Tan, Wenling Qin, Choong Eui Song, Hailong Yan
A chiral fluoride-catalyzed asymmetric cascade sulfa-Michael/aldol condensation reaction of 1,4-dithiane-2,5-diol and a series of α,β-unsaturated ketones is described to access chiral trisubstituted tetrahydrothiophene derivatives. The target products, including the spiro tetrahydrothiophene derivatives bearing a five-, six-, and seven-membered ring, were highly functionalized and showed high ee value. This established protocol realized a highly enantioselective reaction with a catalytic amount of KF and Song's chiral oligoEG via in situ generated chiral fluoride to construct useful heterocyclic skeletons with great complexity...
April 25, 2017: Organic Letters
https://www.readbyqxmd.com/read/28440630/a-hydrolytically-stable-luminescent-cationic-metal-organic-framework-for-highly-sensitive-and-selective-sensing-of-chromate-anion-in-natural-water-systems
#2
Wei Liu, Yanlong Wang, Zhuanling Bai, Yuxiang Li, Yaxing Wang, Lanhua Chen, Lin Xu, Juan Diwu, Zhifang Chai, Shuao Wang
The effective detection of chromate anion in aqueous solution is highly desirable due to its high solubility, environmental mobility, carcinogenicity, and bioaccumulation effect. New strategy for precise detection of chromate anion in the presence of large excess of other anions such as Cl-, NO3-, HCO3- in drinking water and natural water systems remains a challenge. Herein, a hydrolytically stable cationic luminescent europium(III) based metal organic framework (MOF) 1 is successfully synthesized and investigated as a luminescent sensor which exhibits instant and selective luminescence quenching property toward CrO42- in aqueous solutions...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28440500/indirect-effects-of-x-irradiation-on-proliferation-and-osteogenic-potential-of-bone-marrow-mesenchymal-stem-cells-in-a-local-irradiated-rat-model
#3
Ruilian Sun, Guoying Zhu, Jianping Wang, Ling Tong, Jianglong Zhai
Cancer survivors after radiotherapy may suffer a variety of bone‑related adverse side effects, including radioactive osteoporosis and fractures. Localized irradiation is a common treatment modality for malignancies. Recently, a series of reactions and injuries called indirect effects (remote changes in bone when other parts of the body are irradiated) have been reported on the indirect irradiated area of bone tissue after radiotherapy. To address this issue, we developed a rat localized irradiation model...
April 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28439224/richness-in-functional-connectivity-depends-on-the-neuronal-integrity-within-the-posterior-cingulate-cortex
#4
Anton R Lord, Meng Li, Liliana R Demenescu, Johan van den Meer, Viola Borchardt, Anna Linda Krause, Hans-Jochen Heinze, Michael Breakspear, Martin Walter
The brain's connectivity skeleton-a rich club of strongly interconnected members-was initially shown to exist in human structural networks, but recent evidence suggests a functional counterpart. This rich club typically includes key regions (or hubs) from multiple canonical networks, reducing the cost of inter-network communication. The posterior cingulate cortex (PCC), a hub node embedded within the default mode network, is known to facilitate communication between brain networks and is a key member of the "rich club...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28439168/ocular-injuries-in-patients-of-zygomatico-complex-zmc-fractures
#5
Altaf Hussain Malik, Aijaz A Shah, Irshad Ahmad, Babar Ai Shah
PURPOSE: Mid face injuries commonly destroy the integrity of the orbital skeleton, and are frequently complicated by injury to the eye, ranging between 2.7 and 90.6 % as reported in literature. The eye injuries range from simple subconjunctival haemorrhage to globe rupture. The paper aims to study the types of ocular injuries in patients with ZMC fractures. PATIENTS AND METHODS: A study of 67 patients, who had sustained facial trauma sufficient to lead to a facial bone fracture, was undertaken in the department of Oral and Maxillofacial Surgery, Govt Dental College, Srinagar from 2008 to 2014 and the patients received a comprehensive examination by an ophthalmologist within 1 week of injury...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28439158/trigemino-cardiac-reflex-a-phenomenon-neglected-in-maxillofacial-surgery
#6
Udupikrishna M Joshi, Ashwini Munnangi, Kundan Shah, Satishkumar G Patil, Nitin Thakur
BACKGROUND: Trigemino-cardiac reflex is a physiologic response of the body to pressure effects in the region of distribution of the trigeminal nerve. Oral and maxillofacial surgical procedures can induce the development of this reflex, which leads to significant changes in the heart rate and sinus rhythms. This study intends to evaluate the effects of this reflex in patients with facial fractures and its subsequent management. PATIENTS AND METHODS: A total of thirty-seven patients with facial fractures who reported to the Department of Oral and Maxillofacial Surgery at Basaveswar Teaching and General Hospital, Gulbarga during a period from July 2015-March 2016 were considered for the study...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28438645/releasing-the-potential-power-of-terpene-synthases-by-a-robust-precursor-supply-platform
#7
Guangkai Bian, Yichao Han, Anwei Hou, Yujie Yuan, Xinhua Liu, Zixin Deng, Tiangang Liu
Terpenoids represent the largest family of natural products. Their structural diversity is largely due to variable skeletons generated by terpene synthases. However, terpene skeletons found in nature are much more than those generated from known terpene synthases. Most promiscuous terpene synthases (i.e. those that can generate more than one product) have not been comprehensively characterised. Here, we first demonstrated that the promiscuous terpene synthases can produce more variable terpenoids in vivo by converting precursor polyisoprenoid diphosphates of different lengths (C10, C15, C20, C25)...
April 21, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28436761/androgen-and-estrogen-shifts-in-men-before-and-after-bariatric-surgery-and-links-to-vitamins-and-trace-elements
#8
Alberto Rosenblatt, Joel Faintuch, Ivan Cecconello
Androgens and estrogens play a key role regarding sexual life and reproduction. Along with hypotestosteronemia, obese men exhibit a 2-fold increase in estradiol concentration, adversely infl uencing these parameters. Estrogens and adipokines also infl uence bone metabolism, exerting a direct effect on vitamin D, calcium homeostasis and bone health. Bariatric procedures normalize some sex hormones, and may reverse several obesity-related conditions. Estrogens levels may remain elevated postoperatively, and despite its protective effect on the skeleton, bariatric patients are more prone to fractures when compared to the general population...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28436456/synthesis-and-anti-obesity-effects-in-vivo-of-crotadihydrofuran-c-as-a-novel-ppar%C3%AE-antagonist-from-crotalaria-albida
#9
Qin-Hu Sun, Yu Zhang, Gui-Xin Chou
Crotadihydrofuran C (CC) from the herbs of Crotalaria albida is able to inhibit adipocyte differentiation and lipid accumulation. However, the effects of CC on obesity and metabolic disorders have not yet been elucidated. In our study, the first enantioselective synthesis of the 2-isopropenyl dihydrofuran isoflavone skeleton (CC) is described. The convenient and efficient synthetic protocols developed skilfully solve the problems of the ortho-para directing group and Suzuki coupling reaction using a boronic acid pinacol ester that was more stable and easy to obtain...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436031/quantification-of-methamphetamine-in-mouse-thighbones-buried-in-soil
#10
Ken-Ichiro Nakao, Yuki Tatara, Kazuhiko Kibayashi
Bone samples are used for analysis of drugs in decomposed or skeletonized bodies. Toxicological analyses of buried bones are important for determining the causes and circumstances of death. In this study, methamphetamine and amphetamine concentrations in heart blood, thigh muscles, and thighbones were analyzed using solid-phase extraction with liquid chromatography-tandem mass spectrometry. Methamphetamine concentrations in heart blood, thigh muscle, and thighbone ranged from 0.041 to 0.873 μg/mL, 0.649 to 2...
April 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28435731/crystal-structure-and-absolute-configuration-of-4s-5r-6s-4-5-6-trihy-droxy-3-methyl-cyclo-hex-2-enone-gabosine-h
#11
Gaurao D Tibhe, Mario A Macías, Enrique Pandolfi, Valeria Schapiro, Leopoldo Suescun
The mol-ecule of the title keto carbasugar, C7H10O4, is formed by a cyclo-hexene skeleton with an envelope conformation, substituted by carbonyl, methyl and hydroxyl groups. The crystal structure is controlled mainly by a combination of strong O-H⋯O and weak C-H⋯O hydrogen bonds, forming nearly perpendicular chains running parallel to the [110] and [-110] directions. This perpendicularity is caused by a tetra-gonal pseudosymmetry influenced by the similarity between the a and b axes, the value of 90.9770 (10)° of the β angle and the action of a 21 screw axis, which transform each chain into its corresponding nearly orthogonal one...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28434377/a-primary-extraskeletal-osteosarcoma-of-the-mesentery-a-case-report
#12
Nathalie E J van den Broek, Paul Willemsen, Caroline Mattelaer
Extraskeletal osteosarcoma is a rare and invasive malignancy, typically located in the soft tissue without attachment to the skeleton. The present study reports a case of a primary mesenteric extraskeletal osteosarcoma of a 71-year-old woman. The patient complained of an incomplete defecation. Colonoscopy showed an ulcer with impression of external compression of the sigmoid. An additional abdominal computed tomography (CT) scan revealed a large, almost completely calcified, mass in the left lower abdomen causing hydronephrosis of the left kidney...
April 24, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28434287/la-donna-di-ostuni-a-case-of-eclampsia-28-000%C3%A2-years-ago
#13
Pierre-Yves Robillard, Marco Scioscia, Donato Coppola, Jean Chaline, Francesco Bonsante, Silvia Iacobelli
La "Donna di Ostuni", the Lady from Ostuni (fortified medieval city, on the southern Italian Adriatic coast) is the skeleton of "the human most ancient mother" ever found by paleoanthropologists, grave dated of 28,000 years BP. It concerns a 20-years-old woman buried with her baby in her womb estimated at 8 months gestation. To date, the cause of the maternal-fetal deaths is qualified of unknown origin. We propose that eclampsia may be a possible explanation for these deaths (mother and baby together). Eclampsia (convulsions), the curse of human births (non-existent in other mammals), has been described since writings has existed 5000 years ago in all civilisations...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28434198/eukaryotic-diversity-in-late-pleistocene-marine-sediments-around-a-shallow-methane-hydrate-deposit-in-the-japan-sea
#14
M Kouduka, A S Tanabe, S Yamamoto, K Yanagawa, Y Nakamura, F Akiba, H Tomaru, H Toju, Y Suzuki
Marine sediments contain eukaryotic DNA deposited from overlying water columns. However, a large proportion of deposited eukaryotic DNA is aerobically biodegraded in shallow marine sediments. Cold seep sediments are often anaerobic near the sediment-water interface, so eukaryotic DNA in such sediments is expected to be preserved. We investigated deeply buried marine sediments in the Japan Sea, where a methane hydrate deposit is associated with cold seeps. Quantitative PCR analysis revealed the reproducible recovery of eukaryotic DNA in marine sediments at depths up to 31...
April 23, 2017: Geobiology
https://www.readbyqxmd.com/read/28433779/identification-of-new-anti-inflammatory-agents-based-on-nitrosporeusine-natural-products-of-marine-origin
#15
Satish Chandra Philkhana, Abhishek Kumar Verma, Gorakhnath R Jachak, Bibhabasu Hazra, Anirban Basu, D Srinivasa Reddy
Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28433166/chitosan-graphene-oxide-films-and-co2-dried-porous-aerogel-microspheres-interfacial-interplay-and-stability
#16
Sana Frindy, Ana Primo, Hamid Ennajih, Abou El Kacem Qaiss, Rachid Bouhfid, Mohamed Lahcini, El Mokhtar Essassi, Hermenegildo Garcia, Abdelkrim El Kadib
The intimate interplay of chitosan (CS) and graphene oxide (GO) in aqueous acidic solution has been explored to design upon casting, nanostructured "brick-and-mortar" films (CS-GO-f) and by acidic-to-basic pH inversion, porous CO2-dried aerogel microspheres (CS-GO-m). Owing to the presence of oxygenated functional groups in GO, good-quality crack-free hybrid films were obtained. Mechanical properties were improved independently of the GO content and it was found that a 20wt% loading affords hybrid film characterized with a Young modulus three times superior to that reached with the same loading of layered clay...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28432317/psiguajadials-a-k-unusual-psidium-meroterpenoids-as-phosphodiesterase-4-inhibitors-from-the-leaves-of-psidium-guajava
#17
Gui-Hua Tang, Zhen Dong, Yan-Qiong Guo, Zhong-Bin Cheng, Chu-Jun Zhou, Sheng Yin
Bioassay-guided fractionation of the ethanolic extract of the leaves of Psidium guajava led to the isolation of 11 new Psidium meroterpenoids, psiguajadials A-K (1-11), along with 17 known ones (12-28). Their structures and absolute configurations were elucidated by spectroscopic methods and comparison of experimental and calculated ECD. Compounds 1 and 2 represent two unprecedented skeletons of 3,5-diformyl-benzyl phloroglucinol-coupled sesquiterpenoid, while 3 is the first example of Psidium meroterpenoids coupling via an oxepane ring...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431807/rhabdomyosarcoma-of-the-maxillofacial-region-in-children-and-adolescents-report-of-9-cases-and-literature-review
#18
Ioannis Iatrou, Nadia Theologie-Lygidakis, Ourania Schoinohoriti, Fotis Tzermpos, Anna-Maria Vessala
OBJECTIVE: To review clinical presentation, histology, treatment and survival for pediatric maxillofacial rhabdomyosarcoma (RMS) and evaluate the role of surgical treatment. STUDY DESIGN: Retrospective analysis of medical charts. METHODS: Files of patients, treated for primary maxillofacial RMS from 1997 to 2016, were examined for clinical presentation, staging, histology, treatment protocol and complications, recurrence and final outcome...
March 23, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28431451/-experience-with-the-hind-foot-relaxation-boot
#19
Hans Zwipp, Michael Borrmann, Eberhard Walter
The goal of this paper is to report our experience with hindfoot fractures using our specially developed boot, with a follow-up of 557 cases. This boot works like the well-known Allgöwer-Röck ortheses (ARO), but is a hybrid between a boot and an orthesis. It allows full weightbearing without using crutches and completely protects an acutely operated hind foot fracture, hind foot arthrodesis or a hind foot fracture which is suitable for conservative treatment. In its first generation, this boot was custom made and used in 408 cases, from March 1999 to February 2011...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28431276/enzymatic-activity-gene-expression-and-posttranslational-modifications-of-photosynthetic-and-non-photosynthetic-phosphoenolpyruvate-carboxylase-in-ammonium-stressed-sorghum-plants
#20
Cirenia Arias-Baldrich, Clara de la Osa, Nadja Bosch, Isabel Ruiz-Ballesta, José A Monreal, Sofía García-Mauriño
Sorghum plants grown with 5mM (NH4)2SO4 showed symptoms of stress, such as reduced growth and photosynthesis, leaf chlorosis, and reddish roots. Phosphoenolpyruvate carboxylase (PEPC) activity, by supplying carbon skeletons for ammonium assimilation, plays a pivotal role in tolerance to ammonium stress. This work investigated the effect of ammonium nutrition on PPC and PPCK gene expression, on PEPC activity, and on post-translational modifications (PTMs) of PEPC in leaves and roots of sorghum plants. Ammonium increased PEPC kinase (PEPCk) activity and the phosphorylation state of PEPC in leaves, both in light and in the dark, due to increased PPCK1 expression in leaves...
March 31, 2017: Journal of Plant Physiology
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