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https://www.readbyqxmd.com/read/29215843/-influence-of-partial-hepatectomie-on-ammoniumdetoxications-function-of-liver-at-chronic-tetrachlorcarbon-hepatitis
#1
P N Savilov
The purpose. To study the effect of partial hepatectomy (PH) on the main ways of ammonia detoxication in the liver (synthesis of urea and glutamine) in chronic tetrachlorcarbon (CCl4) hepatitis. Methods. The experiments were performed on 165 white outbred rats (females) weighing 180-220 g Chronic CCl4-hepatitis was reproduced by subcutaneous injection of 50% CCl4 solution in olive oil (0.1 ml/100g of body weight,65 days, through the day with two two-week breaks between 6-7 and 13-14 injections). PH conducted electrocautery, removing part of the left lobe of the liver (15-20% by weight of the body) to 65th (and last) day of the introduction of the CCl4...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29204300/yogi-detox-tea-a-potential-cause-of-acute-liver-failure
#2
Keerthana Kesavarapu, Mitchell Kang, Jaewook James Shin, Kenneth Rothstein
We present a case of acute fulminant liver failure from a liver detoxification tea. We present a 60-year-old female with weakness, lethargy, scleral icterus, jaundice, and worsening mental status. She drank herbal tea three times a day for 14 days prior to symptom development. Liver tests were elevated. Remaining laboratory tests and imaging were negative for other etiologies. An ultrasound-guided liver biopsy showed submassive necrosis. A literature search on the ingredients shows six ingredients as having hepatotoxic effects and remaining ingredients as having very sparse hepatoprotective data...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29199901/an-evaluation-of-practitioner-s-experience-of-service-users-seeking-community-detoxification-from-benzodiazepines
#3
Marianne Wall, Sharon Lambert, Aidan Horan
A recent report in Ireland identified that two-thirds of poisoning deaths involved poly drug use with an average of four different drugs involved. Of these, benzodiazepines were the most common drug group involved. Concern has been expressed regarding high levels of benzodiazepine prescriptions globally. Community-based detoxification programs are required, but detoxification is complex with associated high risks, such as overdose. This study utilized a survey to gather the experiences of a range of drug workers in addiction settings in the southern region of Ireland who are tasked with the management of supporting service users who wish to detoxify from benzodiazepines...
December 4, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29191801/inspectors-voice-concern-over-independent-residential-detox-units
#4
Anne Gulland
No abstract text is available yet for this article.
November 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29180167/characterization-of-equine-gst-a3-3-as-a-steroid-isomerase
#5
Helena Lindström, Shawna M Peer, Nancy H Ing, Bengt Mannervik
Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication by making toxic electrophiles more polar and therefore more easily excretable. However some GSTs have developed alternative functions. Thus, a member of the Alpha class GSTs in pig and human tissues is involved in steroid hormone biosynthesis, catalyzing the obligatory double-bond isomerization of Δ5-androstene-3,17-dione to Δ4-androstene-3,17-dione and of Δ5-pregnene-3,20-dione to Δ4-pregnene-3,20-dione on the biosynthetic pathways to testosterone and progesterone...
November 24, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29135117/what-is-the-connection-between-serum-phosphorus-cancer-and-heroin-a-medical-hypothesis-based-on-observational-studies
#6
Vassilis Kouloulias, Christos-David Papaloucas, Aristofanis Papaloucas
Considering the results of a previous study in which 2321 regular heroin addicts who died without having stopped taking the drug since they had started - from various causes but none from cancer, may mean something. Our first thought was: Can't we hypothesize, reinforcing our previous view that heroin is a "barrier" against cancer and as the user gets in the methadone program he/she lacks the "barrier" and therefore is liable to develop cancer? We have already reported that the amount of blood phosphorus in heroin addicted is significantly lower than in healthy ones...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29132086/strengthening-detoxication-impacts-of-coprinus-comatus-on-nickel-and-fluoranthene-co-contaminated-soil-by-bacterial-inoculation
#7
Xia Tang, Bingxin Liu, Qiusui Deng, Ruitao Zhang, Xue Li, Heng Xu
To develop an efficient and environmental-friendly approach to detoxicate nickel (Ni) and fluoranthene co-contaminated soil, the combined application of Coprinus comatus (C. comatus) with Serratia sp. FFC5 and/or Enterobacter sp. E2 was investigated. The pot experiment tested the influences of bacterial inoculation on the growth of C. comatus, content of Ni in C. comatus, Ni speciation in soil, fluoranthene dissipation, soil enzymatic activities, bacterial population and community structure. With the inoculation of bacteria, the fresh weights of C...
November 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29102194/biological-responses-of-neotropical-freshwater-fish-lophiosilurus-alexandri-exposed-to-ammonia-and-nitrite
#8
Márcio José Dos Santos Silva, Franklin Fernando Batista da Costa, Fabiola Paes Leme, Rodrigo Takata, Deliane Cristina Costa, Cristiano Campos Mattioli, Ronald Kennedy Luz, Kleber Campos Miranda-Filho
This study aimed to elucidate the responses of the Neotropical fish Lophiosilurus alexandri exposed to ammonia and nitrite, following a period of recovering. Acute toxicity tests lasted 96h, subchronic toxicity tests lasted eight days and the detoxification trial lasted four days. Groups of 12 juveniles were maintained in 90-L tanks and treated with increasing concentrations of ammonia and nitrite, except during the recovery test. All treatments were performed with two replicates. The median lethal concentrations (LC50) of 24, 48, 72 and 96h were estimated at 30...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096991/intox-detox-antidotes-evidence-based-diagnosis-and-treatment-of-acute-intoxications
#9
Andreas Schaper, Martin Ebbecke
BACKGROUND AND AIM: Aim of this review is to describe the role of clinical toxicology in the context of acute medicine. A special focus is put on antidotes and important aspects of diagnosis and therapy of acute intoxications. The data of the annual report of GIZ-Nord Poisons Centre is analyzed concerning the following aspects: what intoxications are relevant in acute medicine, are there special aspects in therapy, e.g. antidotes, and what antidotes are relevant? More over intoxication-related fatalities are analyzed...
October 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29096055/an-unusual-double-beckmann-fragmentation-reaction-under-physiological-conditions
#10
Lin-Na Xie, Chun-Hua Huang, Dan Xu, Feng Li, Jun-Ge Zhu, Chen Shen, Bo Shao, Hui-Ying Gao, Balaraman Kalyanaraman, Ben-Zhan Zhu
Pyridinium aldoximes, which are best-known as therapeutic antidotes for organophosphorus chemical warfare nerve-agents and pesticides, have been found to markedly detoxify polyhalogenated quinones which are a class of carcinogenic intermediates and recently identified disinfection byproducts in drinking water. However, the exact chemical mechanism underlying this detoxication remains unclear. Here we demonstrate that pralidoxime can remarkably facilitate the dechlorination/hydroxylation of the highly toxic tetrachloro-1, 4-benzoquinone in two-consecutive steps to generate the much less toxic 2, 5-dichloro-3, 6-dihydroxy-1, 4-benzoquonine, with rate enhancements of up to 180,000-times...
November 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29027440/-analysis-on-composition-principles-of-tibetan-medicine-containing-terminalia-chebula-by-data-mining
#11
Wen-Juan Yang, Yong-Zhong Zeweng, Yi Zhang, Zang-Jia Geng, Jia Nie
This study using traditional Chinese medicine inheritance support software(TCMISS) to analyze the prescription rules of Tibetan medicine containing Terminalia chebula in the Encyclopedia of Chinese Medicine-Tibetan Medicine, Tibetan Medicine Composition Preparation of Modern Research and Clinical Application and Common Interpretation of Tibetan Medicine and so on. TCMISS(V2.5) was used to build a prescription database of Tibetan medicine containing T. chebula.The software statistical statement module, association rules and improved mutual information method and other data mining technologies were adopted to analyze the common herbs, combination rules and core combination of prescriptions containing T...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29023394/carbon-based-oxamate-cobalt-iii-complexes-as-bioenzyme-mimics-for-contaminant-elimination-in-high-backgrounds-of-complicated-constituents
#12
Nan Li, Yun Zheng, Xuemei Jiang, Ran Zhang, Kemei Pei, Wenxing Chen
Complex wastewater with massive components is now a serious environmental issue facing humanity. Selective removal of low-concentration contaminants in mixed constituents holds great promise for increasing water supplies. Bioenzymes like horseradish peroxidase exhibit oxidizing power and selectivity. Here, we manufactured its mimic through immobilizing non-heme oxamate anionic cobalt(III) complex ([Co(III)(opba)](-), opba = o-phenylenebis(oxamate)) onto pyridine (Py) modified multiwalled carbon nanotubes ([Co(III)(opba)](-)-Py-MWCNTs, MWCNTs = multiwalled carbon nanotubes), where MWCNTs captured substrates and Py functioned as the fifth ligand...
October 12, 2017: Materials
https://www.readbyqxmd.com/read/29021109/design-and-impact-of-bundled-payment-for-detox-and-follow-up-care
#13
Amity E Quinn, Dominic Hodgkin, Jennifer N Perloff, Maureen T Stewart, Mary Brolin, Nancy Lane, Constance M Horgan
INTRODUCTION: Recent payment reforms promote movement from fee-for-service to alternative payment models that shift financial risk from payers to providers, incentivizing providers to manage patients' utilization. Bundled payment, an episode-based fixed payment that includes the prices of a group of services that would typically treat an episode of care, is expanding in the United States. Bundled payment has been recommended as a way to pay for comprehensive SUD treatment and has the potential to improve treatment engagement after detox, which could reduce detox readmissions, improve health outcomes, and reduce medical care costs...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28985156/barriers-to-accessing-detox-facilities-substance-use-treatment-and-residential-services-among-women-impacted-by-commercial-sexual-exploitation-trafficking
#14
Lara B Gerassi
More than 50% of women entering substance use treatment in the U.S. reported having traded sex for money or drugs. Women's participation in addiction treatment and related services is essential to their recovery and increased safety, stabilization, and quality of life. This paper's aim is to explore the barriers related to accessing detox facilities and essential services including substance use treatment and residential services for women impacted by commercial sexual exploitation (CSE). Data are drawn from a larger, community-based, grounded theory study...
October 6, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28982303/possible-garcinia-cambogia-induced-mania-with-psychosis-a-case-report
#15
David C Nguyen, Tysen K Timmer, Blair C Davison, Ian R McGrane
Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox™ dietary supplement manufactured by Apex Vitality Health...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28942031/the-relationship-between-treatment-accessibility-and-preference-amongst-out-of-treatment-individuals-who-engage-in-non-medical-prescription-opioid-use
#16
Andrew S Huhn, D Andrew Tompkins, Kelly E Dunn
BACKGROUND: Relatively little is known regarding the perception of medication-assisted treatments (MATs) and other treatment options amongst individuals that engage in non-medical prescription opioid use. This study surveyed out-of-treatment individuals that misuse opioids to better understand how perceived access to treatment shapes treatment preference. METHODS: Participants (n=357) were out-of-treatment adults registered as workers on the Amazon Mechanical Turk platform who reported current non-medical prescription opioid use...
November 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28929669/-clinical-analysis-of-modified-chaiping-decoction-in-treating-hbeag-negative-chronic-hepatitis-b
#17
Zheng-Rong Ye, Wei-Xing Du, Lin Wu
To observe the clinical efficacy of modified Chaiping decoction for HBeAg-negative chronic hepatitis B under DaBianZheng theory(syndrome differentiation theory) guidance with understanding of purgative detoxing and modern pharmacology research of traditional Chinese medicine. The patients with HBeAg-negative chronic hepatitis B(n=119) were randomly divided into treatment group(n=69) and control group(n=50). The patients in treatment group were treated with the modified Chaiping decoction(6 doses per week, one dose every day in two times by oral administration), and the patients in control group were treated with lamivudine(LAM) (100 mg/time, once a day)...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28918460/effects-of-cadmium-exposure-on-metal-accumulation-and-energy-metabolism-of-silver-carp-hypophthalmichthys-molitrix
#18
Deliang Li, Jie Pi, Jianping Wang, Pengfei Zhu, Deming Liu, Ting Zhang
Effects of cadmium (Cd) exposure on metal accumulation and energy metabolism of silver carp (Hypophthalmichthys molitrix) were studied during 14 days. The results showed that Cd accumulated in tissues of silver carp significantly with time and Cd concentration, as the order: liver > kidney > gill > muscle. The levels of muscle glycogen, triglyceride, and plasma triglyceride decreased significantly (p < 0.05). The levels of muscle protein, plasma glucose and lactate significantly increased during the first 8 days, and then all significantly decreased (p < 0...
November 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28918271/the-role-of-sulfate-reducing-prokaryotes-in-the-coupling-of-element-biogeochemical-cycling
#19
REVIEW
Peng Bao, Guo-Xiang Li, Guo-Xin Sun, Yao-Yang Xu, Andrew A Meharg, Yong-Guan Zhu
Sulfate-reducing prokaryotes (SRP) represent a diverse group of heterotrophic and autotrophic microorganisms that are ubiquitous in anoxic habitats. In addition to their important role in both sulfur and carbon cycles, SRP are important biotic and abiotic regulators of a variety of sulfur-driven coupled biogeochemical cycling of elements, including: oxygen, nitrogen, chlorine, bromine, iodine and metal(loid)s. SRP gain energy form most of the coupling of element transformation. Once sulfate-reducing conditions are established, sulfide precipitation becomes the predominant abiotic mechanism of metal(loid)s transformation, followed by co-precipitation between metal(loid)s...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28892748/microsomal-glutathione-transferase-2-modulates-ltc4-synthesis-and-ros-production-in-apostichopus-japonicus
#20
Zhen Zhang, Zhimeng Lv, Zhixin Wei, Chenghua Li, Yina Shao, Weiwei Zhang, Xuelin Zhao, Jinbo Xiong
Microsomal glutathione transferase 2 (mGST2) is an integral membrane protein involved in detoxication of xenobiotics, and has also been suggested to catalyze the biosynthesis of pro-inflammatory mediator leukotriene C4 (LTC4) as homologous to LTC4 synthase (LTC4S) in mammals. In the present study, a novel mGST2 homology was identified from Apostichopus japonicus (designated as AjmGST2) by RACE approaches. The full-length cDNA of AjmGST2 was of 1917bp encoding a polypeptide of 161 amino acids residues. Multiple sequences alignment and phylogenetic analysis together supported that AjmGST2 belonged to a new member in invertebrate mGSTs family and close to mammalian LTC4S...
November 2017: Molecular Immunology
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