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https://www.readbyqxmd.com/read/28647874/alleviative-effect-of-licorice-on-copper-chloride-induced-oxidative-stress-in-the-brain-biochemical-histopathological-immunohistochemical-and-genotoxic-study
#1
Heba El-Sayed Mostafa, Eman Ahmad Alaa-Eldin, Dalia Abdallah El-Shafei, Nehal S Abouhashem
Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life, it can be toxic when administered in excess. Licorice (Glycyrrhizaglabra) has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. Here, we test the hypothesis that licorice could ameliorate copper-induced neurotoxic and genotoxic effects in adult male albino rats. For this purpose, 48 adult male albino rats were randomized into five groups: group I (8 rats), untreated control; group II (16 rats), subdivided into; vehicle control IIa (8 rats) which received 1 mL saline twice weekly intraperitoneally for 8 weeks and vehicle control IIb (8 rats) received 0...
June 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28645060/young-people-who-use-drugs-engaged-in-harm-reduction-programs-in-new-york-city-overdose-and-other-risks
#2
Michele Calvo, Jessica MacFarlane, Heather Zaccaro, Matthew Curtis, María Cabán, Jamie Favaro, Marian R Passannante, Taeko Frost
BACKGROUND: Little is known about the engagement of young people who use drugs (PWUD) in harm reduction programs (HRPs), and few studies have included non-opioid users and non-injectors. While HRPs have effectively engaged PWUD, young people are under-represented in their services. METHODS: The Injection Drug Users Health Alliance Citywide Study (IDUCS) is the largest community-based study of PWUD in HRPs in the US. From 2014-2015, 2421 HRP participants across New York City (NYC) completed a cross-sectional survey...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28629539/uplc-esi-qtof-ms-based-metabolomics-survey-on-the-toxicity-of-triptolide-and-detoxication-of-licorice
#3
Zhuo Wang, Jian-Qun Liu, Jin-Di Xu, He Zhu, Ming Kong, Guo-Hua Zhang, Su-Min Duan, Xiu-Yang Li, Guang-Fu Li, Li-Fang Liu, Song-Lin Li
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction (LWE) against such toxicity...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629367/african-american-esophageal-squamous-cell-carcinoma-expression-profile-reveals-dysregulation-of-stress-response-and-detox-networks
#4
Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P Hoffman, Robert G Wadleigh
BACKGROUND: Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. The molecular architecture of African-American ESCC is still poorly understood. It is unclear why African-American ESCC is more aggressive and the survival rate in these patients is worse than those of other ethnic groups...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28576389/healthcare-utilization-in-adults-with-opioid-dependence-receiving-extended-release-naltrexone-compared-to-treatment-as-usual
#5
William E Soares, Donna Wilson, Niels Rathlev, Joshua D Lee, Michael Gordon, Edward V Nunes, Charles P O'Brien, Peter D Friedmann
BACKGROUND: Opioid use disorders have reached epidemic proportions, with overdose now the leading cause of accidental death in the United States. Extended release naltrexone (XR-NTX) has emerged as a medication treatment that reduces opioid use and craving. However, the effect of XR-NTX therapy on acute healthcare utilization, including emergency department visits and inpatient hospitalizations, remains uncertain. The objective of the current study is to evaluate hospital-based healthcare resource utilization in adults involved in the criminal justice system with a history of opioid use disorder randomized to XR-NTX therapy compared with treatment as usual (TAU) during a 6-month treatment phase and 12months post-treatment follow up...
May 12, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28571768/copper-activation-of-organophosporus-compounds-detoxication-by-chicken-serum
#6
Antonio Monroy-Noyola, Miguel Angel Sogorb, Nuria Díaz-Alejo, Eugenio Vilanova
Avian species contain low levels of enzymes that hydrolyze organophosphorus compounds (OPs), and chickens are used as a model of OPs delayed neurotoxicity. For both reasons, we studied the ability of chicken tissue for OP detoxication. A significant activating effect of Cu(2+) on the hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) was observed in hen plasma and the microsomal fractions of the liver, brain, and mainly in hen serum, by spectrophotometric and chiral chromatography methods. The concentration of 1 mM of Cu(2+) or Zn(2+) showed 200% and 168% activation, respectively, in hen plasma compared with the Ca(2+)-dependent hydrolysis, whereas these cations had an inhibitory effect on soluble liver and brain fractions...
May 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28558808/gender-differences-in-discharge-dispositions-of-emergency-department-visits-involving-drug-misuse-and-abuse-2004-2011
#7
Jennifer I Manuel, Jane Lee
BACKGROUND: Drug use-related visits to the emergency department (ED) can undermine discharge planning and lead to recurrent use of acute services. Yet, little is known about where patients go post discharge. We explored trends in discharge dispositions of drug-involved ED visits, with a focus on gender differences. METHODS: We extracted data from the 2004-2011 Drug Abuse Warning Network, a national probability sample of drug-related visits to hospital EDs in the U...
May 30, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28506909/the-selective-effect-of-glycyrrhizin-and-glycyrrhetinic-acid-on-topoisomerase-ii%C3%AE-and-apoptosis-in-combination-with-etoposide-on-triple-negative-breast-cancer-mda-mb-231-cells
#8
Yun Cai, Boxin Zhao, Qianying Liang, Yunqi Zhang, Jieying Cai, Guofeng Li
Triple negative breast cancer(TNBC) has generated growing interests due to its aggressive biologic behavior and absence of targeted therapy approach. Glycyrrhizin(GL) from licorice root and its metabolite, glycyrrhetinic acid(GA) have shown extensive bioactivities in clinic. Here, we demonstrate that GL and GA have contrary anti-cancer effect on TNBC MDA-MB-231 cells. Beside its inhibition of cell proliferation, GA at non-cytotoxic concentration showed synergistic effect in combination with anti-cancer drug, etoposide(VP-16)...
May 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28505487/heroin-refusal-self-efficacy-and-preference-for-medication-assisted-treatment-after-inpatient-detoxification
#9
Shannon R Kenney, Genie L Bailey, Bradley J Anderson, Michael D Stein
OBJECTIVE: An individual's self-efficacy to refuse using heroin in high-risk situations is believed to minimize the likelihood for relapse. However, among individuals completing inpatient heroin detoxification, perceived refusal self-efficacy may also reduce one's perceived need for medication-assisted treatment (MAT), an effective and recommended treatment for opioid use disorder. In the current study, we examined the relationship between heroin refusal self-efficacy and preference for MAT following inpatient detoxification...
May 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28490916/the-cannabis-withdrawal-syndrome-current-insights
#10
REVIEW
Udo Bonnet, Ulrich W Preuss
The cannabis withdrawal syndrome (CWS) is a criterion of cannabis use disorders (CUDs) (Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition) and cannabis dependence (International Classification of Diseases [ICD]-10). Several lines of evidence from animal and human studies indicate that cessation from long-term and regular cannabis use precipitates a specific withdrawal syndrome with mainly mood and behavioral symptoms of light to moderate intensity, which can usually be treated in an outpatient setting...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/28468624/direct-hydrogen-production-from-dilute-acid-pretreated-sugarcane-bagasse-hydrolysate-using-the-newly-isolated-thermoanaerobacterium-thermosaccharolyticum-mj1
#11
Bin-Bin Hu, Ming-Jun Zhu
BACKGROUND: Energy shortage and environmental pollution are two severe global problems, and biological hydrogen production from lignocellulose shows great potential as a promising alternative biofuel to replace the fossil fuels. Currently, most studies on hydrogen production from lignocellulose concentrate on cellulolytic microbe, pretreatment method, process optimization and development of new raw materials. Due to no effective approaches to relieve the inhibiting effect of inhibitors, the acid pretreated lignocellulose hydrolysate was directly discarded and caused environmental problems, suggesting that isolation of inhibitor-tolerant strains may facilitate the utilization of acid pretreated lignocellulose hydrolysate...
May 3, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28450305/mechanisms-in-endocrinology-update-on-pathogenesis-of-primary-adrenal-insufficiency-beyond-steroid-enzyme-deficiency-and-autoimmune-adrenal-destruction
#12
Christa Flueck
Primary adrenal insufficiency (PAI) is potentially life threatening, but rare. In children genetic defects prevail, while adults suffer mostly from acquired forms. The spectrum of genetic defects has increased in recent years with the use of next generation sequencing methods and reaches now far beyond genetic defects in known enzymes of steroidogenesis. Cofactor disorders such as P450 oxidoreductase (POR) deficiency manifesting as a complex form of congenital adrenal hyperplasia with a broad clinical phenotype have come to the forth...
April 27, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28424803/use-of-a-flumazenil-infusion-to-treat-chlordiazepoxide-toxicity
#13
I R Wallace, E C Campbell, M Trimble
"Alcohol detox" is a common presentation to acute medical services and is usually managed via standardised guidelines and protocols. We present a case of chlordiazepoxide toxicity, requiring repeated bolus doses and subsequently 24 hours of an intravenous infusion of flumazenil in response to guideline directed management of an alcohol withdrawal state. The use of prolonged flumazenil infusions to treat benzodiazepine toxicity is infrequently described. Chlordiazepoxide is metabolised in the hepatic microsomal pathway and hepatic impairment can lead to accumulation of toxic metabolites, which may have been the explanation for toxicity in this case...
2017: Acute Medicine
https://www.readbyqxmd.com/read/28408246/renal-protective-effect-and-action-mechanism-of-huangkui-capsule-and-its-main-five-flavonoids
#14
Hong-Die Cai, Shu-Lan Su, Da-Wei Qian, Sheng Guo, Wei-Wei Tao, Xu Dong Cong, Renmao Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The flower of Abelmoschus manihot (Linn.) Medicus (A. manihot), as a traditional Chinese Herbal medicine, was used widely in China with efficacy of inducing diuresis for treating strangurtia, and subdhing swelling and detoxicating. It has been reported that Huangkui capsule, prepared by the extract of the flower of A. manihot, can reduce the content of urinary protein, serum creatinine and serum urea nitrogen in nephropathy rats and processes renoprotective activity, while the action mechanism need to illuminate deeply...
April 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28406517/biochemical-studies-of-inositol-n-acetylglucosaminyltransferase-involved-in-mycothiol-biosynthesis-in-corynebacterium-diphtheria
#15
Yuchuan Guo, Lizhen Wang, Jiatong Guo, Guofeng Gu, Zhongwu Guo
Mycothiol (MSH) is the predominant low molecular weight thiol produced by actinomycetes, and it plays a pivotal role in the bacterial detoxication process. 1L-myo-Inositol-1-phosphate (1L-Ins-1-P) α-N-acetylglucosaminyltransferase (GlcNAc-T), known as MshA, is the only glycosyltransferase involved in MSH biosynthesis. In this work, the MshA from Corynebacterium diphtheria, named as CdMshA, was expressed, purified, and studied in detail. Its enzymatic activity to transfer GlcNAc to 1L-Ins-1-P was confirmed by the isolation and rigorous characterization of its reaction product 3-phospho-1-d-myo-inositol-2-acetamido-2-deoxy-α-d-glucopyranoside...
May 3, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28402675/mechanistic-insight-into-the-molecular-tio2-mediated-gas-phase-detoxication-of-dmmp-a-theoretical-approach
#16
Tamalika Ash, Tanay Debnath, Avik Ghosh, Abhijit Kumar Das
The detoxication of DMMP (dimethyl methylphosphonate) mediated by molecular TiO2 has been investigated computationally using density functional theory (DFT). From our previous studies, it is evident that the unimolecular detoxication of OPCs (organophosphorus compounds) is kinetically unfeasible at room temperature due to the significantly high activation barrier. Thus, the aim of our work is to find out whether molecular TiO2 can make any significant impact on the kinetic feasibility of the detoxication processes or not...
April 27, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28385078/paris-polyphylla-suppresses-proliferation-and-vasculogenic-mimicry-of-human-osteosarcoma-cells-and-inhibits-tumor-growth-in-vivo
#17
Nan Yao, Ke Ren, Yimin Wang, Qiaomei Jin, Xiao Lu, Yan Lu, Cuihua Jiang, Dongjian Zhang, Jun Lu, Chen Wang, Jiege Huo, Yong Chen, Jian Zhang
Paris polyphylla, a traditional antipyretic-detoxicate chinese medicinal herb, has been applied extensively in cancer treatments for nearly 2000 years. The purpose of the present study is to evaluate the potential anti-osteosarcoma effects of Paris polyphylla ethanol extract (PPEE) and to investigate its underlying mechanisms. The antiproliferation activity of PPEE was tested on 143B, MG-63, U-2 OS and hFOB1.19 cells using MTT assay. The pro-apoptotic and cell cycle arrest effects of PPEE were confirmed by Hoechst 33342 staining and flow cytometry...
April 6, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28356881/association-of-gsto1-and-gsto2-polymorphism-with-risk-of-end-stage-renal-disease-development-and-patient-survival
#18
Slavica Cimbaljevic, Sonja Suvakov, Marija Matic, Marija Pljesa-Ercegovac, Tatjana Pekmezovic, Tanja Radic, Vesna Coric, Tatjana Damjanovic, Nada Dimkovic, Rodoljub Markovic, Ana Savic-Radojevic, Tatjana Simic
BACKGROUND: Oxidative stress in patients with end-stage renal disease (ESRD) is associated with long-term cardiovascular complications. The cytosolic family of glutathione S-transferases (GSTs) is involved in the detoxication of various toxic compounds and antioxidant protection. GST omega class members, GSTO1 and GSTO2 possess, unlike other GSTs, dehydroascorbate reductase and deglutathionylation activities. The aim of this study was to clarify the role of genetic polymorphisms of GSTO1 (rs4925) and GSTO2 (rs156697) as risk determinants for ESRD development, as well as in the survival of these patients...
September 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28352354/antifreeze-poisoning-a-case-report
#19
Xiaofei Wu, Guoyu Lu, Benquan Qi, Ran Wang, Daohua Guo, Xiaolin Liu
The current study reported the case of a 35-year-old male that presented with antifreeze poisoning. The clinical manifestations, laboratory investigations and treatments were analyzed, and the obtained results were compared with those in previous reports. Subsequent to consuming antifreeze, the patient mainly presented nausea and agitation, without disturbance of consciousness. Laboratory investigations indicated severe metabolic acidosis, renal dysfunction and hyperkalemia. The patient underwent hemodialysis and his condition was significantly improved on the day of admission...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28240222/intraspecific-variation-among-tetranychid-mites-for-ability-to-detoxify-and-to-induce-plant-defenses
#20
Rika Ozawa, Hiroki Endo, Mei Iijima, Koichi Sugimoto, Junji Takabayashi, Tetsuo Gotoh, Gen-Ichiro Arimura
Two genotypes coexist among Kanzawa spider mites, one of which causes red scars and the other of which causes white scars on leaves, and they elicit different defense responses in host plants. Based on RNA-Seq analysis, we revealed here that the expression levels of genes involved in the detoxification system were higher in Red strains than White strains. The corresponding enzyme activities as well as performances for acaricide resistance and host adaptation toward Laminaceae were also higher in Red strains than White strains, indicating that Red strains were superior in trait(s) of the detox system...
February 27, 2017: Scientific Reports
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