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apneic period

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https://www.readbyqxmd.com/read/27865065/how-do-we-recognize-the-child-with-osas
#1
Koen F Joosten, Helena Larramona, Silvia Miano, Dick Van Waardenburg, Athanasios G Kaditis, Nele Vandenbussche, Refika Ersu
Obstructive sleep-disordered breathing includes a spectrum of clinical entities with variable severity ranging from primary snoring to obstructive sleep apnea syndrome (OSAS). The clinical suspicion for OSAS is most often raised by parental report of specific symptoms and/or abnormalities identified by the physical examination which predispose to upper airway obstruction (e.g., adenotonsillar hypertrophy, obesity, craniofacial abnormalities, neuromuscular disorders). Symptoms and signs of OSAS are classified into those directly related to the intermittent pharyngeal airway obstruction (e...
November 16, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27843043/hyperekplexia-report-on-phenotype-and-genotype-of-16-jordanian-patients
#2
Amira Masri, Seo-Kyung Chung, Mark I Rees
BACKGROUND: Hyperekplexia, is a rare disorder characterized by excessive startle response to acoustic, visual, or other stimuli. It is inherited in autosomal recessive and dominant pattern. OBJECTIVE: To describe the clinical and genetic features of hyperekplexia in Jordanian patients. METHODS: This retrospective study includes all patients with proved genetic diagnosis of hyperekplexia who presented to our clinic at the Jordan University Hospital from January 2001 through July 2015...
November 11, 2016: Brain & Development
https://www.readbyqxmd.com/read/27615064/prognostic-importance-of-novel-oxygen-desaturation-metrics-in-patients-with-heart-failure-and-central-sleep-apnea
#3
Eiichi Watanabe, Ken Kiyono, Shojiro Matsui, Virend K Somers, Kan Sano, Junichiro Hayano, Tomohide Ichikawa, Mayumi Kawai, Masahide Harada, Yukio Ozaki
BACKGROUND: Sleep-disordered breathing, particularly central sleep apnea (CSA), is highly prevalent in heart failure (HF) and an independent prognostic marker. We assessed the hypothesis that an increased hypoxemic burden during sleep may have greater prognostic value than the frequency of apneic and hypopneic episodes. METHODS AND RESULTS: We prospectively conducted overnight cardiorespiratory polygraphy on consecutive HF patients referred to our hospital from 2008 to 2011...
September 9, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27590285/variants-in-slc18a3-vesicular-acetylcholine-transporter-cause-congenital-myasthenic-syndrome
#4
Gina L O'Grady, Corien Verschuuren, Michaela Yuen, Richard Webster, Manoj Menezes, Johanna M Fock, Natalie Pride, Heather A Best, Tatiana Benavides Damm, Christian Turner, Monkol Lek, Andrew G Engel, Kathryn N North, Nigel F Clarke, Daniel G MacArthur, Erik-Jan Kamsteeg, Sandra T Cooper
OBJECTIVE: To describe the clinical and genetic characteristics of presynaptic congenital myasthenic syndrome secondary to biallelic variants in SLC18A3. METHODS: Individuals from 2 families were identified with biallelic variants in SLC18A3, the gene encoding the vesicular acetylcholine transporter (VAChT), through whole-exome sequencing. RESULTS: The patients demonstrated features seen in presynaptic congenital myasthenic syndrome, including ptosis, ophthalmoplegia, fatigable weakness, apneic crises, and deterioration of symptoms in cold water for patient 1...
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27540704/neonatal-experiences-with-ethanol-intoxication-modify-respiratory-and-thermoregulatory-plasticity-and-affect-subsequent-ethanol-intake-in-rats
#5
María Belén Acevedo, Ana Fabiola Macchione, Florencia Anunziata, Olga Beatriz Haymal, Juan Carlos Molina
Different studies have focused on the deleterious consequences of binge-like or chronic exposure to ethanol during the brain growth spurt period (third human gestational trimester) that in the rat corresponds to postnatal days (PDs) 3-10. The present study analyzed behavioral and physiological disruptions caused by relatively brief binge-like exposures (PDs 3, 5, and 7) with an ethanol dose lower (3.0 g/kg) than those frequently employed to examine teratological effects during this stage in development. At PD 9, pups were exposed to ethanol doses ranging between ...
August 19, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27485793/epileptic-phenotype-of-fgfr3-related-bilateral-medial-temporal-lobe-dysgenesis
#6
Tetsuya Okazaki, Yoshiaki Saito, Riyo Ueda, Takeya Awashima, Yoko Nishimura, Isao Yuasa, Yuki Shinohara, Kaori Adachi, Masayuki Sasaki, Eiji Nanba, Yoshihiro Maegaki
Hypochondroplasia (HCH) is a skeletal dysplasia, characterized by short stature and macrocephaly. Clinical symptoms and radiological and histopathological features of HCH are similar, but milder than those seen in achondroplasia. Particularly, HCH patients with Asn540Lys mutation in the FGFR3 gene are reported to have medial temporal lobe dysgenesis and epilepsy. We report a 3-year-old girl who developed recurrent epileptic apnea, which started immediately after birth. The apneic seizures were refractory to antiepileptic medications; ictal electroencephalography showed rhythmic activity originating from the left or right temporal areas and rarely from the right frontal area...
July 30, 2016: Brain & Development
https://www.readbyqxmd.com/read/27468022/epinephrine-or-gv-26-electrical-stimulation-reduces-inhalant-anesthestic-recovery-time-in-common-snapping-turtles-chelydra-serpentina
#7
RANDOMIZED CONTROLLED TRIAL
Alexandra Goe, Justin Shmalberg, Bonnie Gatson, Pia Bartolini, Jeff Curtiss, James F X Wellehan
Prolonged anesthetic recovery times are a common clinical problem in reptiles following inhalant anesthesia. Diving reptiles have numerous adaptations that allow them to submerge and remain apneic for extended periods. An ability to shunt blood away from pulmonary circulation, possibly due to changes in adrenergic tone, may contribute to their unpredictable inhalant anesthetic recovery times. Therefore, the use of epinephrine could antagonize this response and reduce recovery time. GV-26, an acupuncture point with reported β-adrenergic and respiratory effects, has reduced anesthetic recovery times in other species...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27449231/apneic-events-a-proposed-new-target-for-respiratory-safety-pharmacology
#8
Dennis J Murphy
Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ventilatory instability or interruptions in ventilatory rhythm. Ventilatory instability can be identified by the presence of prolonged end-expiratory pauses or apneic periods. An apneic event has been defined as an apneic period of sufficient duration to cause hypoxia (i...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27266401/incorporating-pharmacodynamic-considerations-into-caffeine-therapeutic-drug-monitoring-in-preterm-neonates
#9
Tian Yu, Alfred H Balch, Robert M Ward, E Kent Korgenski, Catherine M T Sherwin
BACKGROUND: This study sought to assess the pharmacokinetic and pharmacodynamic relationships of caffeine citrate therapy in preterm neonates who had therapeutic drug monitoring (TDM) in the post-extubation period. METHODS: A retrospective observational study was conducted in preterm neonates who received caffeine citrate therapy for apnea of prematurity and had TDM done in the post-extubation period between January 2006 and October 2011. The relationships between pharmacodynamic effects (heart rate, respiratory rate, episodes of apnea, adverse events) and caffeine serum concentrations were explored...
2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27152499/hazards-of-intubation-in-the-icu-role-of-nasal-high-flow-oxygen-therapy-for-preoxygenation-and-apneic-oxygenation-to-prevent-desaturation
#10
Jean D Ricard
Acute respiratory failure is one the most common motives for intensive care unit admission. Although results from recent studies with high flow nasal oxygen have challenged our current management of these patients, a substantial number of them will require invasive mechanical ventilation and tracheal intubation. Life-threatening hypoxemia is the most frequent complication of these intubations. Desaturations occur despite properly conducted preoxygenation. Hence, alternatives are warranted to improve oxygenation during intubation...
October 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/26957384/obstructive-sleep-apnea-preoperative-screening-and-postoperative-care
#11
REVIEW
Robert M Wolfe, Jonathan Pomerantz, Deborah E Miller, Rebecca Weiss-Coleman, Tony Solomonides
The incidence of obstructive sleep apnea (OSA) has reached epidemic proportions, and it is an often unrecognized cause of perioperative morbidity and mortality. Profound hypoxic injury from apnea during the postoperative period is often misdiagnosed as cardiac arrest due to other causes. Almost a quarter of patients entering a hospital for elective surgery have OSA, and >80% of these cases are undiagnosed at the time of surgery. The perioperative period puts patients at high risk of apneic episodes because of drug effects from sedatives, narcotics, and general anesthesia, as well as from the effects of postoperative rapid eye movement sleep changes and postoperative positioning in the hospital bed...
March 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/26846234/apneic-oxygenation-is-associated-with-a-reduction-in-the-incidence-of-hypoxemia-during-the-rsi-of-patients-with-intracranial-hemorrhage-in-the-emergency-department
#12
John C Sakles, Jarrod M Mosier, Asad E Patanwala, John M Dicken
Critically ill patients undergoing emergent intubation are at risk of oxygen desaturation during the management of their airway. Patients with intracranial hemorrhage (ICH) are particularly susceptible to the detrimental effects of hypoxemia. Apneic oxygenation (AP OX) may be able to reduce the occurrence of oxygen desaturation during the emergent intubation of these patients. We sought to assess the effect AP OX on oxygen desaturation during the rapid sequence intubation (RSI) of patients with ICH in the emergency department (ED)...
October 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26836712/first-pass-success-without-hypoxemia-is-increased-with-the-use-of-apneic-oxygenation-during-rapid-sequence-intubation-in-the-emergency-department
#13
John C Sakles, Jarrod M Mosier, Asad E Patanwala, Brittany Arcaris, John M Dicken
OBJECTIVES: The objective was to determine the effect of apneic oxygenation (AP OX) on first pass success without hypoxemia (FPS-H) in adult patients undergoing rapid sequence intubation (RSI) in the emergency department (ED). METHODS: Continuous quality improvement data were prospectively collected on all patients intubated in an academic ED from July 1, 2013, to June 30, 2015. During this period the use of AP OX was introduced and encouraged for all patients undergoing RSI in the ED...
June 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26598451/stochastic-resonance-effects-on-apnea-bradycardia-and-oxygenation-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Vincent C Smith, Damian Kelty-Stephen, Mona Qureshi Ahmad, Wenyang Mao, Kelly Cakert, John Osborne, David Paydarfar
OBJECTIVE: To evaluate the effect of stochastic resonance (SR) stimulation on preterm infant oxygen desaturation, bradycardia, and apnea events. We hypothesized that SR stimulation will reduce these events. METHODS: This was a randomized crossover study conducted from April 2012 to July 2014. Eligible preterm infants were not receiving ventilation support and had at least 1 clinically documented apnea, bradycardia, and/or oxygen desaturation event. The 3 outcome variables were as follows: oxygen desaturation, bradycardia, and apnea events...
December 2015: Pediatrics
https://www.readbyqxmd.com/read/26524655/prenatal-nicotinic-exposure-upregulates-pulmonary-c-fiber-nk1r-expression-to-prolong-pulmonary-c-fiber-mediated-apneic-response
#15
Lei Zhao, Jianguo Zhuang, Na Zang, Yong Lin, Lu-Yuan Lee, Fadi Xu
Prenatal nicotinic exposure (PNE) prolongs bronchopulmonary C-fiber (PCF)-mediated apneic response to intra-atrial bolus injection of capsaicin in rat pups. The relevant mechanisms remain unclear. Pulmonary substance P and adenosine and their receptors (neurokinin-A receptor, NK1R and ADA1 receptor, ADA1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) expressed on PCFs are critical for PCF sensitization and/or activation. Here, we compared substance P and adenosine in BALF and NK1R, ADA1R, and TRPV1 expression in the nodose/jugular (N/J) ganglia (vagal pulmonary C-neurons retrogradely labeled) between Ctrl and PNE pups...
January 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26494257/brat1-related-disease-identification-of-a-patient-without-early-lethality
#16
Sheraden A Mundy, Bryan L Krock, Rong Mao, Joseph J Shen
We present a patient with neonatal onset of hypertonia and seizures identified through whole exome sequencing to have compound heterozygous variants, c.294dupA (p.Leu99fs) and c.1925C>A (p.Ala642Glu), in the BRCA1-associated protein required for ATM activation-1 (BRAT1) gene. Variants in BRAT1 have been identified to cause lethal neonatal rigidity and multifocal seizure syndrome (OMIM# 614498), which consistently manifests a severe neurological phenotype that includes neonatal presentation of rigidity and hypertonia, microcephaly and arrested head growth, intractable seizures, absence of developmental progress, apneic episodes, and death usually by 6 months of age...
March 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26474407/utilizing-inspiratory-airflows-during-standard-polysomnography-to-assess-pharyngeal-function-in-children-during-sleep
#17
Brian M McGinley, Jason P Kirkness, Hartmut Schneider, Abhishek Lenka, Philip L Smith, Alan R Schwartz
OBJECTIVES: Obstructive sleep apnea (OSA) is the result of pharyngeal obstruction that occurs predominantly during REM in children. Pathophysiologic mechanisms responsible for upper airway obstruction, however, are poorly understood. Thus, we sought to characterize upper airway obstruction in apneic compared to snoring children during sleep. We hypothesized that apneic compared to snoring children would exhibit an increased prevalence and severity of upper airway obstruction, that would be greater in REM compared to non-REM, and would improve following adenotonsillectomy...
April 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26211866/unusual-foreign-body-in-the-larynx-a-bee
#18
Ethem İlhan, Handan Yaman, Burhan Dost, Gökçe Akman Köse, Hüseyin Yaman
Foreign body lodgement in the larynx is a rare situation. Our review of the literature revealed no living foreign body in larynx except for laryngeal leeches and anisakiasis. In this article, we report a patient with unusual laryngeal foreign body lodgement: a bee which presented with sudden odynophagia and stinging sensation in throat. The bee was detected on the laryngeal mucosa in indirect laryngoscopic examination and removed immediately under general anesthesia in apneic period. In this case report, we describe the importance of detailed anamnesis and laryngeal examination even if the patient has no severe symptoms...
2015: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/26124664/boussignac-cpap-system-for-brain-death-confirmation-with-apneic-test-in-case-of-acute-lung-injury-adult-respiratory-distress-syndrome-series-of-cases
#19
Andrzej Wieczorek, Tomasz Gaszynski
INTRODUCTION: There are some patients with severe respiratory disturbances like adult respiratory distress syndrome (ARDS) and suspicion of brain death, for whom typical performance of the apneic test is difficult to complete because of quick desaturation and rapid deterioration without effective ventilation. To avoid failure of brain death confirmation and possible loss of organ donation another approach to apneic test is needed. We present two cases of patients with clinical symptoms of brain death, with lung pathology (acute lung injury, ARDS, lung embolism and lung infection), in whom apneic tests for recognizing brain death were difficult to perform...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26102686/8c-08-continuous-positive-airway-pressure-is-efficient-to-decrease-blood-pressure-in-patients-with-resistant-hypertension-results-from-the-rhoosas-study
#20
J P Baguet, P Sosner, P Delsart, S Jost, R Tamisier, J L Pepin
OBJECTIVE: Most of patients suffering from resistant hypertension (HTN) have obstructive sleep apnea (OSA). Little data are available to confirm or not the efficacy of continuous positive airway pressure (CPAP) on blood pressure (BP) in resistant HTN. DESIGN AND METHOD: We performed a multicentric, comparative (presence or not of OSA), randomized (sham CPAP then active CPAP versus active CPAP right away), simple blind study in patients with essential resistant HTN (confirmed by ABPM)...
June 2015: Journal of Hypertension
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