keyword
https://read.qxmd.com/read/38484130/phase-2-double-blind-placebo-controlled-trial-of-a-c-jun-n-terminal-kinase-inhibitor-in-idiopathic-pulmonary-fibrosis
#21
JOURNAL ARTICLE
Waldo L L D Mattos, Nasreen Khalil, Lisa G Spencer, Francesco Bonella, Rodney J Folz, J Douglass Rolf, Nesrin Mogulkoc, Lisa H Lancaster, R Gisli Jenkins, David A Lynch, Paul W Noble, Toby M Maher, Vincent Cottin, Stefanie Senger, Gerald S Horan, Steven Greenberg, Zoran Popmihajlov
Rationale : Idiopathic pulmonary fibrosis is a fatal and progressive disease with limited treatment options. Objectives: To assess the efficacy and safety of CC-90001, an oral inhibitor of c-Jun N-terminal kinase 1, in patients with idiopathic pulmonary fibrosis. Methods: NCT03142191 was a phase 2, randomized (1:1:1), double-blind, placebo-controlled study in which patients received CC-90001 (200 or 400 mg) or placebo once daily for 24 weeks. Background antifibrotic treatment (pirfenidone) was allowed. The primary endpoint was change in percentage of predicted forced vital capacity (ppFVC) from baseline to Week 24; secondary endpoints included safety...
March 14, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38478596/poor-in-hospital-congestion-improvement-in-acute-heart-failure-patients-classified-according-to-lvef-prognostic-implications
#22
JOURNAL ARTICLE
Gaetano Ruocco, Nicolas Girerd, Tripti Rastogi, Zohra Lamiral, Alberto Palazzuoli
BACKGROUND: Residual congestion in acute heart failure (AHF) is associated with poor prognosis. However, there is a lack of data on the prognostic value of changes in a combined assessment of in-hospital congestion. The present study sought to assess the association between in-hospital congestion changes and subsequent prognosis according to left ventricular ejection fraction (LVEF) classification. METHODS: Patients (N=244, 80.3±7.6 years, 50.8% male) admitted for acute HF in two European tertiary care centers underwent clinical assessment (congestion score included dyspnea at rest, rales, third heart sound, jugular venous distention, peripheral edema and hepatomegaly; simplified congestion score included rales and peripheral edema), echocardiography, lung ultrasound (LUS) and natriuretic peptides (NP) measurement at admission and discharge...
March 13, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38476210/spontaneous-rupture%C3%A2-induced-life%C3%A2-threatening-mediastinal-mixed-germ-cell-tumor-a-case-report-and-therapeutic-considerations
#23
Xiaosong Li, Shenghan Xu, Yunbin Li, Yanping Tang, Kaiying Wang, Yumeng Lei, Jian Ma, Jian Li
Spontaneous rupture and hemorrhage of mediastinal germ cell tumors is a rare occurrence. In the current report, the case of a 20-year-old male patient who was admitted with chest tightness and dyspnea is presented. An urgent chest CT scan revealed a large tumor in the right anterior mediastinum, measuring ~12 cm in diameter, with associated intratumoral hemorrhage. An emergency thoracotomy was performed to excise the lesion, which revealed that the bleeding was caused by a ruptured tumor. Postoperative pathological findings revealed a mediastinal mixed germ cell tumor consisting of four pathological types: Embryonal carcinoma, seminoma, yolk sac tumor and immature teratoma...
April 2024: Oncology Letters
https://read.qxmd.com/read/38469863/comparison-of-the-muscle-oxygenation-during-submaximal-and-maximal-exercise-tests-in-patients-post-coronavirus-disease-2019-syndrome-with-pulmonary-involvement
#24
JOURNAL ARTICLE
Başak Kavalcı Kol, Meral Boşnak Güçlü, Ece Baytok, Nilgün Yılmaz Demirci
INTRODUCTION: Pulmonary involvement is prevalent in patients with coronavirus disease 2019 (COVID-19). Arterial hypoxemia may reduce oxygen transferred to the skeletal muscles, possibly leading to impaired exercise capacity. Oxygen uptake may vary depending on the increased oxygen demand of the muscles during submaximal and maximal exercise. OBJECTIVE: This study aimed to compare muscle oxygenation during submaximal and maximal exercise tests in patients with post-COVID-19 syndrome with pulmonary involvement...
March 12, 2024: Physiotherapy Theory and Practice
https://read.qxmd.com/read/38468264/cardiopulmonary-exercise-test-to-detect-cardiac-dysfunction-from-pulmonary-vascular-disease
#25
REVIEW
Mona Alotaibi, Jenny Z Yang, Demosthenes G Papamatheakis, W Cameron McGuire, Timothy M Fernandes, Timothy A Morris
BACKGROUND: Cardiac dysfunction from pulmonary vascular disease causes characteristic findings on cardiopulmonary exercise testing (CPET). We tested the accuracy of CPET for detecting inadequate stroke volume (SV) augmentation during exercise, a pivotal manifestation of cardiac limitation in patients with pulmonary vascular disease. METHODS: We reviewed patients with suspected pulmonary vascular disease in whom CPET and right heart catheterization (RHC) measurements were taken at rest and at anaerobic threshold (AT)...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38465877/dyspnea-breathlessness-in-amyotrophic-lateral-sclerosis-motor-neuron-disease-prevalence-progression-severity-and-correlates
#26
JOURNAL ARTICLE
Carolyn A Young, Amina Chaouch, Christopher J Mcdermott, Ammar Al-Chalabi, Suresh K Chhetri, Kevin Talbot, Timothy Harrower, Richard W Orrell, Joe Annadale, Oliver C Hanemann, Antonio Scalfari, Alan Tennant, Roger Mills
Objective : Dyspnea, or breathlessness, is an important symptom in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND). We examined the measurement properties of the Dyspnea-12. Methods : Rasch analysis enabled conversion of raw Dyspnea-12 scores to interval level metric equivalents. Converted data were used to perform trajectory modeling; those following different trajectories were compared for demographic, clinical, symptom, and functioning characteristics. Logistic regression examined differences between distinct trajectories...
March 11, 2024: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://read.qxmd.com/read/38455374/the-predictive-role-of-lactate-in-the-emergency-department-in-patients-with-severe-dyspnea
#27
JOURNAL ARTICLE
Maciej Niczewski, Szymon Gawęda, Paulina Kluszczyk, Mikołaj Rycerski, Daria Syguła, Anna Danel, Szymon Szmigiel, Konrad Mendrala, Aleksandra Oraczewska, Czarosław Kijonka, Monika Nowicka, Michał Wita, Tomasz Cyzowski, Grzegorz Brożek, Maciej Dyrbuś, Szymon Skoczyński
OBJECTIVE: An accurate identification of patients at the need for prioritized diagnostics and care are crucial in the emergency department (ED). Blood gas (BG) analysis is a widely available laboratory test, which allows to measure vital parameters, including markers of ventilation and perfusion. The aim of our analysis was to assess whether blood gas parameters in patients with dyspnea at an increased risk of respiratory failure admitted to the ED can predict short-term outcomes. METHODS: The study group eventually consisted of 108 patients, with available BG analysis...
2024: Emergency Medicine International
https://read.qxmd.com/read/38454352/post-recovery-health-domain-scores-among-outpatients-by-sars-cov-2-testing-status-during-the-pre-delta-period
#28
JOURNAL ARTICLE
Jennifer P King, Jessie R Chung, James G Donahue, Emily T Martin, Aleda M Leis, Arnold S Monto, Manjusha Gaglani, Kayan Dunnigan, Chandni Raiyani, Sharon Saydah, Brendan Flannery, Edward A Belongia
BACKGROUND: Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination. METHODS: Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness onset at three US Flu Vaccine Effectiveness Network sites were tested for SARS-CoV-2 by molecular assay...
March 8, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38445127/emergency-department-management-of-common-end-of-life-and-palliative-care-symptoms-three-cases
#29
Alice Chang, James Espinosa, Alan Lucerna
The emergency department (ED) is at times the only place where patients can turn for symptom relief. Patients of all ages may turn to the ED for help with the management of end-of-life (EOL) and palliative care (PC) symptoms. Emergency medicine (EM) is a specialty that manages disease-directed treatment for a variety of acute conditions. In contrast, EOL and PC are focused on improving quality of life. Patients with serious illness, even hospice patients, present to the ED in increasing numbers for symptom management...
February 2024: Curēus
https://read.qxmd.com/read/38444988/quality-of-life-impact-of-diaphragm-plication-in-patients-with-diaphragmatic-paralysis-a-retrospective-study
#30
JOURNAL ARTICLE
Jasmin Valenti, Khea Tan, Kelly Rubino, Ziad Hanhan, Dennis Vega, Matthew Kaufman, Thomas Bauer
OBJECTIVES: While the overall incidence and prevalence of diaphragmatic paralysis are unknown due to a wide variety of underlying causes, symptomatic patients experience a marked decline in their quality of life. The goal of this study was to measure the impact of diaphragm plication surgery on the quality of life in patients who were diagnosed with diaphragmatic paralysis. METHODS: A retrospective review of the medical records of 46 patients who underwent diaphragmatic plication surgery was performed...
2024: Annals of Thoracic Medicine
https://read.qxmd.com/read/38441579/-management-of-ear-nose-and-throat-emergencies
#31
JOURNAL ARTICLE
J Taeger, M Goncalves, T A Duong Dinh, J Ilgner, G Michels, S Hackenberg
Emergency situations involving the ears, nose, and throat (ENT) area can pose considerable challenges for clinicians and often require an interdisciplinary approach due to the involvement of different organ systems. To avoid damage to highly relevant sensory and perception organs and life-threatening bleeding or respiratory complications, strategies that are as quick and targeted as possible are necessary. This article aims to provide an overview of ENT emergency management strategies. The entire spectrum from simple conservative to highly complex surgical measures plays a role here, both diagnostically and therapeutically...
March 5, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38433236/left-ventricular-and-atrial-myocardial-strain-in-heart-failure-with-preserved-ejection-fraction-the-evidence-so-far-and-prospects-for-phenotyping-strategy
#32
REVIEW
Mariane Higa Shinzato, Natasha Santos, Gustavo Nishida, Henrique Moriya, Jorge Assef, Fausto Feres, Renato A Hortegal
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) represents a significant proportion of heart failure cases. Accurate diagnosis is challenging due to the heterogeneous nature of the disease and limitations in traditional echocardiographic parameters. MAIN BODY: This review appraises the application of Global Longitudinal Strain (GLS) and Left Atrial Strain (LAS) as echocardiographic biomarkers in the diagnosis and phenotyping of HFpEF. Strain imaging, particularly Speckle Tracking Echocardiography, offers a superior assessment of myocardial deformation, providing a more detailed insight into left heart function than traditional metrics...
March 4, 2024: Cardiovascular Ultrasound
https://read.qxmd.com/read/38431058/impact-of-biologics-on-lung-hyperinflation-in-patients-with-severe-asthma
#33
JOURNAL ARTICLE
Mauro Maniscalco, Claudio Candia, Cecilia Calabrese, Maria D'Amato, Maria Gabriella Matera, Antonio Molino, Mario Cazzola
BACKGROUND: In asthma, inflammation affects both the proximal and distal airways and can cause significant hyperinflation, which is thought to be a major cause of dyspnea. METHODS: This is a retrospective observational study evaluating the effect of three months of treatment with different biologic drugs (benralizumab, dupilumab and omalizumab) on pulmonary hyperinflation in a cohort of patients with severe asthma already receiving regular triple inhaled therapy...
February 29, 2024: Respiratory Medicine
https://read.qxmd.com/read/38423822/screening-for-frailty-using-the-frail-scale-in-older-cancer-survivors-a-cross-sectional-comparison-with-the-fried-phenotype
#34
JOURNAL ARTICLE
Denise Shuk Ting Cheung, Mu-Hsing Ho, Pui Hing Chau, Doris Sau Fung Yu, Wing Lok Chan, Sung Inda Soong, Jean Woo, Chia Chin Lin
OBJECTIVES: To examine the diagnostic performance of the FRAIL Scale for frailty screening with reference to the Fried phenotype and investigate its association with health outcomes in older cancer survivors. DATA SOURCE: In this cross-sectional quantitative study, participants were post-treatment cancer survivors aged 65 or above. Measurements included the FRAIL Scale, Fried phenotype, Geriatric Depression Scale-15 item, Modified Barthel Inventory, and EORTC Core Quality of Life Questionnaire...
February 28, 2024: Seminars in Oncology Nursing
https://read.qxmd.com/read/38416659/the-impact-of-positive-expiratory-pressure-therapy-on-hyperinflation-in-patients-with-copd
#35
REVIEW
Juliana Ribeiro Fonseca Franco de Macedo, Elinaldo da Conceiçãodos Dos Santos, Gregory Reychler, William Poncin
BACKGROUND: Lung hyperinflation is a typical clinical feature of patients with COPD. Given the association between breathing at elevated lung volumes and the manifestation of severe debilitating symptoms, therapeutic interventions such as positive expiratory pressure (PEP) therapy and its variations (temporary, oscillatory) have been devised to mitigate lung hyperinflation. However, the efficacy of these interventions remains to be conclusively demonstrated. METHODS: A systematic review with meta-analysis of randomized trials was conducted following the PRISMA guidelines...
February 28, 2024: Respiratory Care
https://read.qxmd.com/read/38415425/-natriuretic-peptides-in-the-diagnosis-and-monitoring-of-heart-failure
#36
JOURNAL ARTICLE
Emmanuelle Berthelot, Ludivine Eliahou, Annabelle Jagu, Thibaud Damy, Olivier Hanon, Jean-Sébastien Hulot, Christophe Meune, Clemence Roig, François Roubille, Pierre Sabouret, Damien Logeart, Nathan Mewton
NATRIURETIC PEPTIDES IN THE DIAGNOSIS AND MONITORING OF CARDIAC FAILURE. Heart failure (HF) is a serious and common disease requiring a prompt diagnosis for appropriate management. Natriuretic peptides, such as BNP and NT-proBNP, play a crucial role in diagnosing HF due to their s pecificity and reproducibility. It is important to measuring natriuretic peptides, especially in cases of acute dyspnea, to differentiate cardiac causes from others. Specific thresholds are recommended, with high values strongly suggest HF, while normal levels rule out the diagnosis...
February 2024: La Revue du Praticien
https://read.qxmd.com/read/38410298/non-exercise-activity-thermogenesis-correlated-with-clinical-parameters-in-patients-with-or-at-risk-for-chronic-obstructive-pulmonary-disease-copd-a-pilot-study
#37
JOURNAL ARTICLE
Sanehiro Yogi, Toru Shirahata, Hideaki Sato, Yuki Nishida, Kaiji Inoue, Mamoru Niitsu, Tomoe Akagami, Kenji Masaki, Makoto Nagata, Shigeho Tanaka, Fuminori Katsukawa, Hidetoshi Nakamura
BACKGROUND: Attention to physical activity has grown in patients with chronic obstructive pulmonary disease (COPD), as it serves as a robust indicator for mortality associated with COPD. Non-exercise activity thermogenesis (NEAT) is the energy expenditure due to physical activities besides active sports-like exercises and resistance training in daily life, and decreased NEAT may be related to physical inactivity in patients with COPD. We examined whether NEAT assessed using a questionnaire reflects clinical parameters in patients with or at risk for COPD...
January 2024: Curēus
https://read.qxmd.com/read/38406039/a-case-of-pneumocystis-pneumonia-developed-during-rheumatoid-arthritis-treatment-with-methotrexate-and-golimumab
#38
Toyoshi Yanagihara, Yusuke Oka, Atushi Moriwaki, Yuki Moriuchi, Hiroaki Ogata, Akiko Ishimatsu, Junji Otsuka, Kazuhito Taguchi, Makoto Yoshida
Here, we report a case of an 87-year-old female patient with rheumatoid arthritis (RA) treated with methotrexate (MTX) and golimumab who developed severe pneumocystis pneumonia (PCP), also known as Pneumocystis jirovecii  pneumonia. The patient presented with chief complaints of dyspnea on exertion, dry cough, and fatigue. A high-resolution chest CT scan revealed diffuse, unevenly distributed ground-glass opacities throughout both lungs. The patient was clinically diagnosed with PCP based on the clinical settings, imaging, and a high level of serum β-D-glucan...
January 2024: Curēus
https://read.qxmd.com/read/38405753/characteristics-and-determinants-of-pulmonary-long-covid
#39
Michael John Patton, Donald Benson, Sarah W Robison, Raval Dhaval, Morgan L Locy, Kinner Patel, Scott Grumley, Emily B Levitan, Peter Morris, Matthew Might, Amit Gaggar, Nathaniel Erdmann
RATIONALE: Persistent cough and dyspnea are prominent features of post-acute sequelae of SARS-CoV-2 (termed 'Long COVID'); however, physiologic measures and clinical features associated with these pulmonary symptoms remain poorly defined. OBJECTIVES: Using longitudinal pulmonary function testing (PFTs) and CT imaging, this study aimed to identify the characteristics and determinants of pulmonary Long COVID. METHODS: The University of Alabama at Birmingham Pulmonary Long COVID cohort was utilized to characterize lung defects in patients with persistent pulmonary symptoms after resolution primary COVID infection...
February 14, 2024: medRxiv
https://read.qxmd.com/read/38400684/common-and-distinct-risk-factors-that-influence-more-severe-and-distressing-shortness-of-breath-profiles-in-oncology-outpatients
#40
JOURNAL ARTICLE
Joosun Shin, Marilyn Hammer, Mary E Cooley, Bruce A Cooper, Steven M Paul, Frances Cartwright, Kord M Kober, Yvette P Conley, Jon D Levine, Christine Miaskowski
BACKGROUND: Shortness of breath occurs in 10%-70% of oncology patients. Very little is known about interindividual variability in its severity and distress and associated risk factors. Using latent profile analyses (LPAs), purpose was to identify subgroups of patients with distinct severity and distress profiles for shortness of breath as single symptom dimensions. In addition, a joint LPA was done using patients' severity AND distress ratings. For each of the three LPAs, differences among the shortness of breath classes in demographic, clinical, symptom, stress, and resilience characteristics were evaluated...
February 2024: Cancer Medicine
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