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Dyspnea measurment

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https://www.readbyqxmd.com/read/29130390/investigation-of-the-differences-between-the-tibetan-and-han-populations-in-the-hemoglobin-oxygen-affinity-of-red-blood-cells-and-in-the-adaptation-to-high-altitude-environments
#1
Cuiying Li, Xiaowei Li, Juan Liu, Xiu Fan, Guoxing You, Lian Zhao, Hong Zhou, Jingqi Li, Huifen Lei
OBJECTIVE: High altitude is characterized by low oxygen pressure, resulting in multiple adaptive responses. Tibetans who have lived in the plateau for thousands of years have developed unique phenotypes, such as downregulation of the HIF pathway through EPAS1 and EGLN1 gene mutation. However, the changes of hemoglobin-oxygen affinity under hypoxia environment remain elusive. METHODS: A blood cell analyzer and a blood oxygen analyzer were used to conduct routine blood tests and measure the oxygen affinity P50 in in the Han population that rapidly entered the plateau (for 3-7 days), the plateau-acclimatized Han population (residing for 30 days on the plateau), the plateau Han population (more than 10 years on the plateau), and the Tibetan population...
November 12, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29127558/effect-of-dexamethasone-dose-and-route-on-the-duration-of-interscalene-brachial-plexus-block-for-outpatient-arthroscopic-shoulder-surgery-a-randomized-controlled-trial
#2
Darren Holland, Ryan J J Amadeo, Scott Wolfe, Linda Girling, Faylene Funk, Mark Collister, Emily Czaplinski, Celeste Ferguson, Jeff Leiter, Jason Old, Peter MacDonald, Brenden Dufault, Thomas C Mutter
PURPOSE: Dexamethasone prolongs the duration of interscalene block, but the benefits of higher doses and perineural vs intravenous administration remain unclear. METHODS: This factorial design, double-blinded trial randomized 280 adult patients undergoing ambulatory arthroscopic shoulder surgery at a single centre in a 1:1:1:1 ratio. Patients received ultrasound-guided interscalene block with 30 mL 0.5% bupivacaine and 4 mg or 8 mg dexamethasone by either the perineural or intravenous route...
November 10, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29126871/lumacaftor-ivacaftor-in-patients-with-cystic-fibrosis-and-advanced-lung-disease-homozygous-for-f508del-cftr
#3
Jennifer L Taylor-Cousar, Manu Jain, Tara Lynn Barto, Tarik Haddad, Jeffrey Atkinson, Simon Tian, Rui Tang, Gautham Marigowda, David Waltz, Joseph Pilewski
OBJECTIVE: Evaluation of the safety, tolerability, and efficacy of lumacaftor/ivacaftor in patients with cystic fibrosis (CF) with severe lung disease. METHODS: Patients with CF 12 years of age and older, homozygous for F508del-CFTR, with percent predicted forced expiratory volume in 1 second (ppFEV1) <40 received lumacaftor 400 mg/ivacaftor 250mg every 12h (full dose) for 24weeks in an open-label, prospective study (NCT02390219). Dose modification to half dose for 1-2weeks (including at initiation) was permitted...
November 7, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29120968/effect-of-pulmonary-rehabilitation-on-inspiratory-capacity-during-6-min-walk-test-in-patients-with-copd-a-prospective-controlled-study
#4
Marc Spielmanns, Tobias Boeselt, Christoph Nell, Jenny Eckhoff, Rembert Andreas Koczulla, Fridericke Sophie Magnet, Jan Hendrik Storre, Wolfram Windisch, Klaus Baum
PURPOSE: Purpose of this study was to analyze the impact of a pulmonary rehabilitation (PR) program on the measured inspiratory capacity (IC) in patients with chronic obstructive pulmonary disease (COPD) while performing a 6-min walk test (6MWT). METHODS: Before and after PR, IC was measured by spirometry both at the beginning and at the end of the 6MWT for 15 patients with COPD in the PR group (PRG) and compared with a similar calisthenics training group (CTG; n = 15)...
November 8, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29105961/ultrasound-and-haematological-changes-during-the-early-luteal-phase-in-women-at-high-risk-for-developing-ovarian-hyperstimulation-syndrome
#5
George T Lainas, Tryfon G Lainas, Christos A Venetis, Ioannis A Sfontouris, Ioannis Z Zorzovilis, Efthymia Alexopoulou, Basil C Tarlatzis, Efstratios M Kolibianakis
OBJECTIVE: To assess ultrasound and haematological changes in ovarian hyperstimulation syndrome (OHSS) during the early luteal phase in women at high risk for developing OHSS. METHODS: This is a retrospective cohort study of 319 women undergoing in-vitro fertilisation (IVF), at high risk for OHSS following human chorionic gonadotrophin (hCG) triggering of final oocyte maturation. Patients were treated with GnRH agonist or antagonist protocol and were monitored for 5 days post oocyte retrieval...
November 6, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29097843/a-case-report-of-ventricular-septal-defect-in-an-adult-sprague-dawley-rat
#6
Tetsuro Kurotaki, Yuki Tomonari, Junko Sato, Takeshi Kanno, Minoru Tsuchitani
A 20-week-old male Sprague Dawley rat noted with decreased body weight, dyspnea, and anorexia beginning 2 days before death was necropsied in the recovery period of a sub-chronic toxicity study. The heart was severely enlarged (30 × 20 × 20 mm), 3-4 times larger than normal, with an approximately 6 mm wide defect in the upper, membranous portion of the ventricular septum. Both ventricles measured 4 mm in thickness, and the right ventricle was 4 times thicker than normal. According to a microscopic examination, the myocardial fibers were severely hypertrophic in the right ventricle and mildly hypertrophic in the left ventricle and septum...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29097629/increased-respiratory-neural-drive-and-work-of-breathing-in-exercise-induced-laryngeal-obstruction
#7
Emil Schwarz Walsted, Azmy Faisal, Caroline J Jolley, Laura L Swanton, Matthew J Pavitt, Yuan-Ming Luo, Vibeke Backer, Michael I Polkey, James H Hull
Rationale: Exercise induced laryngeal obstruction (EILO), a phenomenon in which the larynx closes inappropriately during physical activity, is a prevalent cause of exertional dyspnea in young individuals. The physiological ventilatory impact of EILO and its relationship to dyspnea are poorly understood. Objectives: To evaluate exercise related changes in laryngeal aperture on ventilation, pulmonary mechanics and respiratory neural drive. Methods: We prospectively evaluated 12 subjects (six with EILO and six healthy age- and gender-matched controls)...
November 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29095750/the-use-of-regional-or-neuraxial-anesthesia-for-below-knee-amputations-may-reduce-the-need-for-perioperative-blood-transfusions
#8
Obaid Malik, Ethan Y Brovman, Richard D Urman
BACKGROUND AND OBJECTIVES: Amputations of the lower extremity remain a common procedure in a high-risk population. Perioperative morbidity and mortality reach as high as 14.1% in below-knee amputations. We aimed to determine whether regional, or neuraxial, anesthesia, when compared with general anesthesia (GA), would be associated with reduced perioperative morbidity and mortality. METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Program data set...
November 1, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29094875/heart-failure-with-preserved-ejection-fraction-diagnosis-and-management
#9
John D Gazewood, Patrick L Turner
Heart failure with preserved ejection fraction, also referred to as diastolic heart failure, causes almost one-half of the 5 million cases of heart failure in the United States. It is more common among older patients and women, and results from abnormalities of active ventricular relaxation and passive ventricular compliance, leading to a decline in stroke volume and cardiac output. Heart failure with preserved ejection fraction should be suspected in patients with typical symptoms (e.g., fatigue, weakness, dyspnea, orthopnea, paroxysmal nocturnal dyspnea, edema) and signs (S3 heart sound, displaced apical pulse, and jugular venous distension) of chronic heart failure...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#10
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29074091/fibroblast-growth-factor-23-in-patients-with-acute-dyspnea-data-from-the-akershus-cardiac-examination-ace-2-study
#11
Magnus Nakrem Lyngbakken, Mohammad Osman Pervez, Jon Brynildsen, Marit Holmefjord Pedersen, Janne Sølvernes, Geir Christensen, Arne Didrik Høiseth, Torbjørn Omland, Helge Røsjø
BACKGROUND: Circulating fibroblast growth factor 23 (FGF23) concentrations have been linked to left ventricular remodeling and unfavorable cardiovascular outcomes, but whether FGF23 is associated with heart failure (HF) diagnosis and outcome in unselected patients with dyspnea is unknown. Accordingly, we assessed the diagnostic and prognostic properties of FGF23 in patients presenting to the emergency department with acute dyspnea. METHODS AND RESULTS: FGF23 was measured in 314 patients admitted with acute dyspnea and the diagnostic and prognostic merit was compared to that of N-terminal pro-B-type natriuretic peptide (NT-proBNP)...
October 24, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29067627/physical-functioning-and-symptoms-of-chronic-fatigue-in-sarcoidosis-patients
#12
K Pilzak, A Żebrowska, M Sikora, B Hall, O Łakomy, S Kostorz, D Ziora, D Jastrzębski
Scientific reports underscore the importance of measuring the health-related quality of life in sarcoidosis patients. The present study seeks to define how sarcoidosis patients' quality of life, daily physical activity, and physical performance are related to each other. Seventeen patients (mean age 46.8 ± 8.8 years) suffering from sarcoidosis completed the following questionnaires: the fatigue assessment scale (FAS), the quality of life scale (SF-36 questionnaire), and the Borg dyspnea scale. Physical activity (PA) was assessed using accelerometry...
October 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29064440/psycho-physiological-associates-of-dyspnea-in-hospitalized-patients-with-interstitial-lung-diseases-a-cross-sectional-study
#13
Yan Hua Zhou, Yim Wah Mak
Dyspnea has been found to be an independent predictor of mortality among patients with respiratory diseases and is often regarded as a difficult symptom to control in patients with interstitial lung diseases (ILDs). Previous studies have found an association of psychological and physiological factors with dyspnea among patients with chronic obstructive airway diseases. However, symptom management of hospitalized patients with ILDs has been hampered by difficulty in priority, since they are often admitted with multiple psycho-physiological needs...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29063807/unilateral-pleural-effusion-as-the-sole-clinical-presentation-of-severe-ovarian-hyperstimulation-syndrome-a-systematic-review
#14
Mohamad Irani, Alex Robles, Vinay Gunnala, Pak Chung, Zev Rosenwaks
The pathophysiology of isolated pleural effusion in ovarian hyperstimulation syndrome (OHSS) is not well defined. The objective of the current review is to delineate the pathophysiology, risk factors, preventive measures, and therapeutic options of isolated pleural effusion in severe OHSS. Major databases were searched until June 2016. Studies evaluating women who presented with pleural effusion as the sole extra-ovarian manifestation of severe OHSS were included. Data were extracted from 24 articles encompassing 30 reported cases...
October 24, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29050126/-clinical-analysis-of-rituximab-induced-interstitial-lung-disease
#15
C Huang, Z W Lu, Y Q Yang, H Chen, D P Huang, H S He
Objective: To investigate the clinical characteristics, diagnosis-treatment points and prognosis of rituximab-induced interstitial lung disease (R-ILD), and to improve the recognition of this disease. Methods: The clinical data on 4 cases of R-ILD were analyzed retrospectively, and the related literatures were reviewed. The literature review was carried out respectively in Wanfang Data, CNKI and PubMed by October 2016 with"rituximab"and"interstitial lung disease"or"interstitial pneumonitis"as the search terms...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#16
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29042764/the-association-between-objectively-measured-physical-activity-and-morning-symptoms-in-copd
#17
Amanda R van Buul, Marise J Kasteleyn, Niels H Chavannes, Christian Taube
PURPOSE: The morning is the most bothersome period for COPD patients. Morning symptom severities in different Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages are not well studied. Furthermore, factors that are associated with morning symptoms, especially the associations with objectively measured physical activity, are also not well described. MATERIALS AND METHODS: The aim of this cross-sectional observational study was to assess morning symptom severity in GOLD A, B, C and D patients, according to the definitions of the GOLD 2015 statement...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29037221/high-flow-oxygen-via-nasal-cannulae-in-patients-with-acute-hypoxemic-respiratory-failure-a-systematic-review-and-meta-analysis
#18
Murdoch Leeies, Eric Flynn, Alexis F Turgeon, Bojan Paunovic, Hal Loewen, Rasheda Rabbani, Ahmed M Abou-Setta, Niall D Ferguson, Ryan Zarychanski
BACKGROUND: We performed a systematic review and meta-analysis to evaluate the efficacy and safety of high-flow oxygen via nasal cannulae (HFNC) compared to non-invasive ventilation (NIV) and/or standard oxygen in patients with acute, hypoxemic respiratory failure. METHODS: We reviewed randomized controlled trials from CENTRAL, EMBASE, MEDLINE, Scopus and the International Clinical Trials Registry Platform (inception to February 2016), conference proceedings, and relevant article reference lists...
October 16, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29024708/nationwide-quality-of-hospice-care-findings-from-the-centers-for-medicare-medicaid-services-cms-hospice-quality-reporting-program-hqrp
#19
Nan Tracy Zheng, Qinghua Li, Laura C Hanson, Kathryn L Wessell, Natalie Chong, Noha Sherif, Ila H Broyles, Jennifer Frank, M Alexis Kirk, Carol R Schwartz, Alan F Levitt, Franziska Rokoske
BACKGROUND: With increasing use of the Medicare hospice benefit, policymakers recognize the need for quality measurement to assure that terminally ill patients receive high quality care and have the information they need when selecting a hospice. Towards these goals, CMS has been collecting standardized patient-level quality data via the Hospice Item Set (HIS) since July 1, 2014. OBJECTIVES: This article presents a first look at the national hospice HIS quality data...
October 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29017478/effectiveness-of-pulmonary-rehabilitation-in-patients-with-interstitial-lung-disease-of-different-etiology-a-multicenter-prospective-study
#20
Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti, Enrico M Clini
BACKGROUND: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. METHODS: Forty-one patients (IPF 63%, age 66...
October 10, 2017: BMC Pulmonary Medicine
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