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Dyspnea measurment

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https://www.readbyqxmd.com/read/28926296/randomised-controlled-trial-of-urokinase-versus-placebo-for-non-draining-malignant-pleural-effusion
#1
Eleanor K Mishra, Amelia O Clive, Genevieve H Wills, Helen E Davies, Andrew E Stanton, Mohamed Al-Aloul, Alan Hart-Thomas, Justin Pepperell, Matthew Evison, Tarek Saba, Richard Neil Harrison, Anur Guhan, Matthew E Callister, Ramamurthy Sathyamurthy, Sunita Rehal, John P Corcoran, Robert Hallifax, Ioannis Psallidas, Nicky Russell, Rachel Shaw, Melissa Dobson, John M Wrightson, Alex West, Y C Gary Lee, Andrew J Nunn, Robert F Miller, Nick A Maskell, Najib M Rahman
RATIONALE: Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, improving drainage. OBJECTIVES: To assess the effects of intrapleural urokinase on dyspnea and pleurodesis success in patients with non-draining malignant effusion. METHODS: Prospective double blind randomised trial; patients with non-draining effusion were randomly allocated 1:1 to intrapleural urokinase (100,000 IU three doses 12 hourly) or matched placebo...
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925009/efficacy-of-patients-preferred-exercise-modalities-in-chronic-obstructive-pulmonary-disease-a-parallel-group-randomized-clinical-trial
#2
Meng Wu, Lu-Qian Zhou, Shi Li, Su Zhao, Hui-Jun Fan, Jie-Min Sun, Xiao-Nan Li, Jian Luo, An-Qi Wang, Jian-Ping Wu, Xiaoying Li, Jin-Nong Zhang
INTRODUCTION: Physical exercise effectively improves health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, application of this medical intervention is problematic, due to poor adherence to the exercise program or unawareness of the significance of this intervention. OBJECTIVE: To determine whether COPD patients who adopted personal-preferred exercise modalities (PPEMs) for daily training would demonstrate sustained benefits due to improved adherence...
September 19, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28921042/symptomatic-treatment-of-dyspnea-in-advanced-cancer-patients-a%C3%A2-narrative-review-of-the-current-literature
#3
REVIEW
Matthäus Strieder, Martin Pecherstorfer, Gudrun Kreye
BACKGROUND: Dyspnea is a common, very distressing symptom in advanced cancer patients that challenges them, their relatives, and healthcare professionals. This narrative review summarizes important literature dealing with the evidence for opioids, benzodiazepines, oxygen, and steroids for treating dyspnea in advanced cancer patients. METHODS: A selective literature search was undertaken in PubMed, Embase, and the Cochrane Library and extended with literature from the reference lists of included studies up to April 2016...
September 18, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28919733/cycle-ergometer-and-inspiratory-muscle-training-offer-modest-benefit-compared-with-cycle-ergometer-alone-a-comprehensive-assessment-in-stable-copd-patients
#4
Kai Wang, Guang-Qiao Zeng, Rui Li, Yu-Wen Luo, Mei Wang, Yu-He Hu, Wen-Hui Xu, Lu-Qian Zhou, Rong-Chang Chen, Xin Chen
BACKGROUND: Cycle ergometer training (CET) has been shown to improve exercise performance of the quadriceps muscles in patients with COPD, and inspiratory muscle training (IMT) may improve the pressure-generating capacity of the inspiratory muscles. However, the effects of combined CET and IMT remain unclear and there is a lack of comprehensive assessment. MATERIALS AND METHODS: Eighty-one patients with COPD were randomly allocated to three groups: 28 received 8 weeks of CET + IMT (combined training group), 27 received 8 weeks of CET alone (CET group), and 26 only received 8 weeks of free walking (control group)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28918335/modern-diagnosis-of-chronic-thromboembolic-pulmonary-hypertension
#5
Aileen Kharat, Anne-Lise Hachulla, Stéphane Noble, Frédéric Lador
Chronic thromboembolic pulmonary hypertension (CTEPH) should be suspected in patients presenting persistent dyspnea three months after a pulmonary embolism or in patients presenting with acute pulmonary embolism and suggestive images on the CT-scan. For these patients, a specific diagnostic work-up should be performed. First step consists of the ventilation/perfusion (V/Q) scan which is a good screening test due to its high sensitivity and high negative predictive value. Pulmonary angiography remains the gold standard approach for the confirmation of the diagnosis and pre-surgical evaluation of CTEPH...
September 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28916479/dietary-nitrate-increases-vo2peak-and-performance-but-does-not-alter-ventilation-or-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#6
Andrew R Coggan, Seth R Broadstreet, Kiran Mahmood, Deana Mikhalkova, Michael Madigan, Indra Bole, Soo Park, Joshua L Leibowitz, Ana Kadkhodayan, Deepak P Thomas, Dakkota Thies, Linda R Peterson
BACKGROUND: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak O2 uptake (VO2peak) during exercise. Dietary nitrate (NO3(-)), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3(-) ingestion on exercise responses in eight patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. METHODS AND RESULTS: Plasma NO3(-), nitrite (NO2(-)), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11...
September 12, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28901555/dyspnea-catastrophizing-and-neural-activations-during-the-anticipation-and-perception-of-dyspnea
#7
M Cornelia Stoeckel, Roland W Esser, Matthias Gamer, Christian Büchel, Andreas von Leupoldt
Dyspnea is an aversive symptom in various diseases. High levels of negative affectivity are typically associated with increased dyspnea and changes in its neural processing. Recently, more dyspnea-specific forms of negative affectivity such as dyspnea catastrophizing were suggested to contribute to increased perception of dyspnea beyond effects of rather unspecific negative affectivity such as general anxiety levels. The involved neural mechanisms have not yet been explored. Therefore, the present retrospective analysis examined the associations of dyspnea catastrophizing with neural activations during the anticipation and perception of dyspnea...
September 13, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28894957/efficacy-of-a%C3%A2-multidisciplinary-pulmonary-rehabilitation-outpatient-program-on-exacerbations-in-overweight-and-obese-patients-with-asthma
#8
Ipek Candemir, Pinar Ergun, Dicle Kaymaz
BACKGROUND: Even though many studies have investigated the effectiveness of weight loss interventions, the efficacy of pulmonary rehabilitation (PR) has not yet been proven in obese patients with asthma. The aims of this study were to investigate the efficacy of PR on asthma exacerbations in the first year after PR and to evaluate the efficacy of PR in exercise capacity, quality of life, psychosocial symptoms and control of asthma in overweight patients. METHODS: The exercise capacity, health-related quality of life scores, psychosocial symptoms, asthma control test (ACT) data, number of emergency admissions and hospitalizations of 35 overweight patients with asthma who completed a 1-year multidisciplinary PR program were recorded and analyzed...
September 11, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28883929/frailty-and-patient-reported-outcomes-in-subjects-with-chronic-obstructive-pulmonary-disease-are-they-independent-entities
#9
Masaaki Kusunose, Toru Oga, Saya Nakamura, Yoshinori Hasegawa, Koichi Nishimura
INTRODUCTION: There is a hypothesis that chronic obstructive pulmonary disease (COPD) is an accelerated ageing disease. Frailty is a geriatric syndrome characterised by physical, psychological and social vulnerability, thought to be a feature of ageing. The authors aimed to explore the relationship between frailty and physiological and patient-reported outcomes (PROs) in subjects with stable COPD. METHODS: We administered the Kihon Checklist that has been validated for frailty screening...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883532/patterns-of-oxygen-pulse-curve-in-response-to-incremental-exercise-in-patients-with-chronic-obstructive-pulmonary-disease-an-observational-study
#10
Ming-Lung Chuang, I-Feng Lin, Shih-Feng Huang, Meng-Jer Hsieh
In COPD, pulmonary hyperinflation causes decreased stroke volume thereby decreased oxygen pulse (O2P). While O2P flattening is related to myocardial ischemia in cardiac patients, O2P patterns have seldom been explored in COPD. The aims of the study were to investigate O2P-curve patterns and associated factors in COPD. Seventy-five patients with stable COPD were enrolled. The demographics, cardiac size, physiological measurements and stress EKG were compared among O2P-curve pattern groups. An algorithm to identify O2P-curve patterns was developed in 28 patients...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874613/diaphragmatic-thickness-fraction-in-subjects-at-high-risk-for-copd-exacerbations
#11
Emel Eryüksel, Canan Cimşit, Melahat Bekir, Çagatay Cimsit, Sait Karakurt
BACKGROUND: Ultrasound-based diaphragmatic thickness fraction is a reflection of the size and function of the diaphragm. This study aimed to examine the value of this measurement in identifying patients with COPD who are at high risk for the development of symptoms and exacerbations. METHODS: This cross-sectional study included 53 subjects with COPD. Respiratory function test results, ultrasonography-based diaphragmatic thickness, symptom scores (modified Medical Research Council dyspnea scale); COPD Assessment Test results, and number of previous exacerbations and admissions were recorded...
September 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28871585/exhaled-nitric-oxide-atopy-and-spirometry-in-asthma-and-rhinitis-patients-in-india
#12
Raj Kumar, Nitesh Gupta
INTRODUCTION: Asthma is a chronic airway inflammatory disorder. Nitric oxide (NO) is non-invasively measured in exhaled breath (FeNO). The aim of the study was to investigate the anthropometric and physiologic factors that influence FeNO measurements. Also, to evaluate FeNO correlation with spirometry and inflammatory markers in asthma and rhinitis. MATERIAL AND METHODS: The study was a prospective analysis of asthma (BA) and rhinitis (AR) in patients enrolled from outpatient clinics between 2011 and 2015...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28867413/vagal-withdrawal-and-psychological-distress-during-ventilator-weaning-and-the-related-outcomes
#13
Yu-Ju Chen, Shiow-Li Hwang, Chi-Rong Li, Chia-Chen Yang, Kun-Lun Huang, Chih-Yuan Lin, Ching-Yi Lee
OBJECTIVE: This study investigated the associations between changes in autonomic nervous system (ANS) function, psychological status during the mechanical ventilation (MV) weaning process, and weaning outcomes. METHODS: In this prospective study, we recruited 67 patients receiving MV for >24h at a medical center in northern Taiwan. Patients' ANS function, represented by heart rate variability (HRV), the rapid shallow breathing index (RSBI), anxiety, fear, and dyspnea, was repeatedly measured 10min before and 30min after undergoing a weaning trial...
July 29, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28860743/systematic-review-of-the-association-between-exercise-tests-and-patient-reported-outcomes-in-patients-with-chronic-obstructive-pulmonary-disease
#14
REVIEW
Yogesh Suresh Punekar, John H Riley, Emily Lloyd, Maurice Driessen, Sally J Singh
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is an increasingly common cause of death worldwide. Its cardinal symptoms include breathlessness and severely reduced exercise capacity. Several patient-reported outcome (PRO) measures are used to assess health-related quality of life (HRQoL), functional performance, and breathlessness in patients with COPD. Exercise testing is employed to measure functional performance objectively, which is generally believed to impact on overall HRQoL...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28851442/outcome-of-surgical-repair-of-pectus-excavatum-in-adults
#15
Ayman M Shaalan, Ibrahim Kasb, Eman E Elwakeel, Yusra A Elkamali
BACKGROUND: Pectus Excavatum (PEx) is the most common congenital chest wall deformity, accounting for over 90% of all chest wall deformities. Surgical correction is recommended because severe PEx can affect the physical and psychological development of patients. The aim of our study was to assess the impact of surgical repair of Pectus Excavatum in adults during hospital course and results after 1 year. METHODS: Prospective study was carried out on 86 adult patients aged ≥ 15 years, 52 males and 34 females (mean age was 26 ± 1...
August 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28846444/validity-of-fractional-exhaled-nitric-oxide-and-small-airway-function-indices-in-diagnosis-of-cough-variant-asthma
#16
Chen Feng-Jia, Huang Xin-Yan, Lin Geng-Peng, Liu Yang-Li, Xie Can-Mao
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a non-invasive method used to reveal the eosinophilic inflammation of airway and to diagnose and manage asthma. The diagnostic value of FeNO in patients with cough variant asthma (CVA) is poorly understood. Small airways remain an important aspect of CVA. The use of FeNO measurement or its combination with the small airway function in differentiating CVA patients from chronic cough patients is unexplored. METHODS: From December 2012 to June 2016, patients with chronic nonproductive cough for more than 8 weeks without any wheezing or dyspnea, fever or blood-stained sputum, and abnormalities on X-ray or larger airways function based on physician's opinion were subjected to FeNO, pulmonary function, and bronchial hyperresponsiveness (BHR) tests...
August 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28832892/bronchial-wheezing-predicts-inflammation-and-respiratory-failure-in-fire-smoke-victims
#17
E R Nakstad, H C D Aass, H Opdahl, A Witsø, F Borchsenius, F Heyerdahl, O H Skjønsberg
BACKGROUND: Acute fire smoke inhalation injury involves inflammatory mediators whose roles are poorly understood. We carried out a prospective observational study of fire smoke victims to identify clinical and biochemical markers that may predict pulmonary dysfunction and investigated possible correlations between dysfunction and cytokines in bronchoalveolar lavage (BAL) fluid and blood. METHODS: Forty patients with respiratory and/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months...
August 17, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28827944/palliative-care-for-patients-with-nonmalignant-respiratory-disease
#18
Nishkarsh Gupta, Rakesh Garg, Vinod Kumar, Sachidanand Jee Bharati, Seema Mishra, Sushma Bhatnagar
Nonmalignant respiratory diseases are chronic and life-limiting conditions that need holistic palliative care. Such patients not only have a variety of physical symptoms such as dyspnea, pain, cough, depression, and anxiety, but also have a number of psychosocial and spiritual issues, which are not addressed to by us. This leads to a poor quality of life. Hence, these patients require supportive palliative care to relieve their sufferings, but unfortunately such care is not available to them in our country...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28821988/presentation-and-management-of-symptomatic-central-bone-cement-embolization
#19
Ahmed Samir Barakat, Tamer Owais, Mohamed Alhashash, Mootaz Shousha, Hesham El Saghir, Bernward Lauer, Heinrich Boehm
BACKGROUND CONTEXT: With more cement augmentation procedures done, the occurrence of serious complications is also expected to rise. Symptomatic central cement embolization is a rare but very serious complication. Moreover, the pathophysiology and treatment of intrathoracic cement embolism remain controversial. PURPOSE: In this case series, we are trying to identify various presentations and suggest our emergent management scheme for symptomatic central cement embolization...
August 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28817366/trajectory-of-dyspnea-and-respiratory-distress-among-patients-in-the-last-month-of-life
#20
Margaret L Campbell, Jason M Kiernan, John Strandmark, Hossein N Yarandi
BACKGROUND: The trajectory of dyspnea has been reported among patients approaching the end of life. However, patients near death have been dropped from longitudinal studies or excluded altogether because of an inability to self-report; proxy estimates have been reported. It is not known whether dyspnea or respiratory distress remains stable, escalates, or abates as patients reach last days. OBJECTIVE: Determine trajectory of dyspnea (self-reported) and respiratory distress (observed) among patients who were approaching death...
August 17, 2017: Journal of Palliative Medicine
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