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https://www.readbyqxmd.com/read/28214411/non-transplant-therapies-for-patients-with-hepatocellular-carcinoma-and-child-pugh-turcotte-class-b-cirrhosis
#1
REVIEW
Alessandro Granito, Luigi Bolondi
Underlying liver cirrhosis is present in most patients with hepatocellular carcinoma, and liver transplantation is the only treatment strategy to cure both diseases. All other hepatocellular carcinoma treatment strategies have to take into account residual liver function that concurs with the patient's prognosis and might limit their feasibility. In patients with hepatocellular carcinoma and Child-Pugh-Turcotte class B (CPT-B), owing to borderline liver function, any intervention might be offset by liver function deterioration...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28214402/relationship-between-chewing-ability-and-cognitive-impairment-in-the-rural-elderly
#2
Eun-Kyong Kim, Sung Kook Lee, Youn-Hee Choi, Makiko Tanaka, Kimiko Hirotsu, Hyeon Chang Kim, Hee-Kyung Lee, Yun-Sook Jung, Atsuo Amano
OBJECTIVE: Relationship between masticatory function and cognitive impairment had been suggested but still understudied. We investigated the association between chewing ability and cognitive impairment among the elderly living in a rural region. METHODS: A total of 295 elderly individuals aged ≥70 years in a rural city of Korea participated in a cross-sectional study. Trained nurses conducted interviews and assessed chewing ability using gum that changed color based on chewing performance...
February 11, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28214234/reablement-reactivation-rehabilitation-and-restorative-interventions-with-older-adults-in-receipt-of-home-care-a-systematic-review
#3
REVIEW
Joanie Sims-Gould, Catherine E Tong, Lutetia Wallis-Mayer, Maureen C Ashe
OBJECTIVE: To systematically review the impact of reablement, reactivation, rehabilitation, and restorative (4R) programs for older adults in receipt of home care services. DESIGN: Systematic review. DATA SOURCES: We searched the following electronic bibliographic databases: MEDLINE, EMBASE, PsycINFO, CINAHL (Cumulative Index to Nursing and Allied Health), SPORTDiscus and The Cochrane Library and reference lists. STUDY SELECTION: Randomized controlled trials that describe original data on the impact of home-based rehabilitative care and were written in English...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214194/orthogeriatric-activity-in-a-general-hospital-of-castilla-la-mancha-spain
#4
J M Fernández-Ibáñez, M C Morales-Ballesteros, E Crespo-Romero, S Gómez-Gómez, M D Fraga-Fuentes, J Cruz-Tejado, P A Hernández-Zegarra, Á Arias-Arias, M M García-Baltasar
AIM: To describe the orthogeriatric activity in the elderly with hip fractures in the Hospital Mancha Centro, based on the recommendations of the main guidelines. MATERIAL AND METHOD: Observational prospective study, comprising all patients over 65 years of age admitted to the Traumatology Unit with a hip fracture between April 2015 and December 2015. Patients were admitted under the care of the Traumatology Unit with cross-consultation carried out with the Geriatrics Department, which then carried out a pre-operative geriatric assessment and the post-operative follow-ups...
February 14, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28214189/economic-assessment-of-rotavirus-vaccination-in-saudi-arabia
#5
Amal Y A Al-Aidaroos, Baudouin Standaert, Kinga Meszaros, Atef M Shibl
In the Kingdom of Saudi Arabia (KSA), rotavirus universal mass vaccination has been introduced in 2013, however, there is limited information available on the economic benefit and the epidemiological impact of the programme to date. We used a Markov cohort model to evaluate and compare the economic value of rotavirus vaccination with no vaccination in a birth cohort of 562,428 infants. This lifetime analysis considered the societal perspective. Model input was obtained through consensus of local experts after two rounds of evaluation of the proposed estimates...
February 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28214167/psychometric-evaluation-and-design-of-patient-centered-communication-measures-for-cancer-care-settings
#6
Bryce B Reeve, David M Thissen, Carla M Bann, Nicole Mack, Katherine Treiman, Hanna K Sanoff, Nancy Roach, Brooke E Magnus, Jason He, Laura K Wagner, Rebecca Moultrie, Kathryn D Jackson, Courtney Mann, Lauren A McCormack
OBJECTIVE: To evaluate the psychometric properties of questions that assess patient perceptions of patient-provider communication and design measures of patient-centered communication (PCC). METHODS: Participants (adults with colon or rectal cancer living in North Carolina) completed a survey at 2 to 3 months post-diagnosis. The survey included 87 questions in six PCC Functions: Exchanging Information, Fostering Health Relationships, Making Decisions, Responding to Emotions, Enabling Patient Self-Management, and Managing Uncertainty...
February 10, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28214146/impact-of-anti-tnf-therapy-on-nk-cells-function-and-on-immunosurveillance-against-b-cell-lymphomas
#7
Gaetane Nocturne, Saida Boudaoud, Bineta Ly, Juliette Pascaud, Audrey Paoletti, Xavier Mariette
OBJECTIVES: Rheumatoid arthritis (RA) is associated with an increased risk of lymphoma linked to activity of the disease. Immunosuppressive drugs have been suspected to induce an additional risk. Since, NK cells have been recently shown to participate to anti-lymphoma immunosurveillance, we aimed to assess if anti-TNF might impact their anti-lymphoma activity. METHODS: NK cells have been assessed ex vivo in patients with RA treated with methotrexate (MTX) with or without anti-TNF...
February 14, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28214098/is-perceived-athlete-leadership-quality-related-to-team-effectiveness-a-comparison-of-three-professional-sports-teams
#8
Katrien Fransen, S Alexander Haslam, Clifford J Mallett, Niklas K Steffens, Kim Peters, Filip Boen
OBJECTIVES: Researchers have argued that leadership is one of the most important determinants of team effectiveness. The present study examined the extent to which the perceived quality of athlete leadership was related to the effectiveness of elite sports teams. DESIGN: Three professional football teams (N=135) participated in our study during the preparation phase for the Australian 2016 season. METHODS: Players and coaching staff were asked to assess players' leadership quality in four leadership roles (as task, motivational, social, and external leader) via an online survey...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28214040/reinforcement-of-intestinal-epithelial-barrier-by-arabinoxylans-in-overweight-and-obese-subjects-a-randomized-controlled-trial-arabinoxylans-in-gut-barrier
#9
Bouke N Salden, Freddy J Troost, Ellen Wilms, Pilar Truchado, Ramiro Vilchez-Vargas, Dietmar H Pieper, Ruy Jáuregui, Massimo Marzorati, Tom van de Wiele, Sam Possemiers, Ad A Masclee
BACKGROUND & AIMS: Obesity and metabolic diseases are associated with alterations in microbial composition and impaired gut barrier. Previous in vitro and animal studies have shown that arabinoxylans (AX) have the potential to modulate gut microbiota and gut barrier and therefore could have a protective role. Primary aim of the study was to investigate the effect of AX on intestinal permeability. Secondary aims included the effect of AX on gene transcription and protein expression of tight junctions (TJ), intestinal microbiota composition and activity, immune response and metabolic markers in overweight and obese individuals...
February 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28214023/using-aequorin-probes-to-measure-ca-2-in-intracellular-organelles
#10
REVIEW
María Teresa Alonso, Macarena Rodríguez-Prados, Paloma Navas-Navarro, Jonathan Rojo-Ruiz, Javier García-Sancho
Aequorins are excellent tools for measuring intra-organellar Ca(2+) and assessing its role in physiological and pathological functions. Here we review targeting strategies to express aequorins in various organelles. We address critical topics such as probe affinity tuning as well as normalization and calibration of the signal. We also focus on bioluminescent Ca(2+) imaging in nucleus or mitochondria of living cells. Finally, recent advances with a new chimeric GFP-aequorin protein (GAP), which can be used either as luminescent or fluorescent Ca(2+) probe, are presented...
January 16, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28214014/controlling-the-digital-ulcerative-disease-in-systemic-sclerosis-is-associated-with-improved-hand-function
#11
Luc Mouthon, Patrick H Carpentier, Catherine Lok, Pierre Clerson, Virginie Gressin, Eric Hachulla, Alice Bérezné, Elisabeth Diot, Aurélie Khau Van Kien, Patrick Jego, Christian Agard, Anne-Bénédicte Duval-Modeste, Agnès Sparsa, Eve Puzenat, Marie-Aleth Richard
OBJECTIVES: Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan. METHODS: ECLIPSE (Study AC-052-517) is a 2-year prospective, multicenter, and observational study. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan were included between October 2009 and March 2011...
January 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28213914/novel-method-to-assess-intrinsic-heart-rate-recovery-in-ambulatory-ecg-recordings-tracks-cardioprotective-effects-of-chronic-autonomic-regulation-therapy-in-patients-enrolled-in-the-anthem-hf-study
#12
Gerrard M Carlson, Imad Libbus, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Postexercise heart rate recovery (HRR) is a powerful and independent predictor of mortality. Autonomic regulation therapy (ART) with chronic vagus nerve stimulation (VNS) has been shown to improve ventricular function in patients with chronic heart failure. However, the effect of ART on HRR in patients with heart failure remains unknown. METHODS: A new measure involving quantification of intrinsic HRR was developed for 24-hr ambulatory ECG (AECG) recordings based on spontaneous heart rate changes observed during daily activity in patients with symptomatic heart failure and reduced ejection fraction...
February 17, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28213901/high-throughput-assays-to-assess-the-functional-impact-of-genetic-variants-a-road-towards-genomic-driven-medicine
#13
J Ipe, M Swart, K S Burgess, T C Skaar
No abstract text is available yet for this article.
February 18, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28213841/sitagliptin-down-regulates-retinol-binding-protein-4-and-reduces-insulin-resistance-in-gestational-diabetes-mellitus-a-randomized-and-double-blind-trial
#14
Xia Sun, Zhendong Zhang, Hui Ning, Hong Sun, Xianghong Ji
Gestational diabetes mellitus (GDM) is a condition that affects increasing number of pregnant women worldwide. Sitagliptin was reported to alleviate symptoms of type 2 diabetes mellitus by reducing serum levels of retinol-binding protein 4 (RBP-4). We investigated the effectiveness of sitagliptin on insulin sensitivity parameters in GDM patients. Pregnant GDM women in the 2nd trimester were recruited for this study. Participants were then assigned randomly to sitagliptin treatment group or placebo treatment group, and administered sitagliptin or placebo daily for 16 weeks...
February 17, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28213832/dynamic-fluorescence-microscopy-of-cellular-uptake-of-intercalating-model-drugs-by-ultrasound-activated-microbubbles
#15
B H A Lammertink, R Deckers, M Derieppe, I De Cock, I Lentacker, G Storm, C T W Moonen, C Bos
PURPOSE: The combination of ultrasound and microbubbles can facilitate cellular uptake of (model) drugs via transient permeabilization of the cell membrane. By using fluorescent molecules, this process can be studied conveniently with confocal fluorescence microscopy. This study aimed to investigate the relation between cellular uptake and fluorescence intensity increase of intercalating model drugs. PROCEDURES: SYTOX Green, an intercalating fluorescent dye that displays >500-fold fluorescence enhancement upon binding to nucleic acids, was used as a model drug for ultrasound-induced cellular uptake...
February 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28213814/translation-and-validation-of-tools-for-assessing-health-related-quality-of-life-and-male-sexual-function-in-hong-kong-chinese-patients-during-transitional-cancer-survivorship
#16
Ka Ming Chow, Carmen W H Chan, Winnie K W So, Doris Y P Leung
No abstract text is available yet for this article.
February 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28213806/clinical-ugt1a1-genetic-analysis-in-pediatric-patients-experience-of-a-reference-laboratory
#17
Ann M Moyer, Jennifer M Skierka, Katrina E Kotzer, Michelle L Kluge, John L Black, Linnea M Baudhuin
BACKGROUND: Neonatal hyperbilirubinemia can be severe or prolonged and warrant exploration into the underlying etiology, which may include genetic assessment of UGT1A1 for inherited disorders (i.e. Crigler-Najjar syndrome or Gilbert syndrome). METHODS: In our reference laboratory, we performed UGT1A1 gene sequencing analysis on 346 pediatric patients referred for a clinical indication of hyperbilirubinemia. RESULTS: Males (n = 241) had significantly higher mean total bilirubin concentration compared to females (n = 105) (9...
February 17, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28213783/high-pten-gene-expression-is-a-negative-prognostic-marker-in-human-primary-breast-cancers-with-preserved-p53-function
#18
Synnøve Yndestad, Eilin Austreid, Stian Knappskog, Ranjan Chrisanthar, Peer Kåre Lilleng, Per Eystein Lønning, Hans Petter Eikesdal
PURPOSE: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer given neoadjuvant chemotherapy. METHODS: The association between pretreatment PTEN and PTENP1 gene expression, response to neoadjuvant chemotherapy, and recurrence-free and disease-specific survival was assessed in 364 patients with locally advanced breast cancer given doxorubicin, 5-fluorouracil/mitomycin, or epirubicin versus paclitaxel in three phase II prospective studies...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28213772/the-effect-of-purinergic-signaling-via-the-p2y11-receptor-on-vascular-function-in-a-rat-model-of-acute-inflammation
#19
Maria D Dănilă, Andreea Privistirescu, Oana M Duicu, Corina D Rațiu, Denis Angoulvant, Danina M Muntean, Adrian Sturza
There is a growing body of evidence pointing to the role of purinergic signaling in the development and progression of various conditions that have inflammation as a common pathogenetic denominator. The aim of the present study was to assess the involvement of P2Y11 purinergic receptors in the regulation of vascular function in aortic segments obtained using an experimental model of acute inflammation, the lipopolysaccharide (LPS, 8 mg/kg, i.p)-treated rats. Twelve hours after LPS administration, thoracic aortas were isolated and used for studies of vascular reactivity in the organ bath and for the measurement of reactive oxygen species (ROS) generation, respectively...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213762/association-between-cognitive-impairment-and-urinary-dysfunction-in-parkinson-s-disease
#20
Zuzanna Tkaczynska, Andrea Pilotto, Sara Becker, Susanne Gräber-Sultan, Daniela Berg, Inga Liepelt-Scarfone
Urinary dysfunction (UD) is a common non-motor feature of Parkinson's disease (PD), and might be secondary to neurodegeneration involving cortical and subcortical brain areas. The possible link between UD and cognitive deficits has never been examined in frontal cortex impairment, and is still not completely understood in PD. In the present study, 94 PD patients underwent a comprehensive motor, cognitive and non-motor assessment. It was shown that 55.3% of patients reported UD, of which 17% needed specific urological treatment...
February 17, 2017: Journal of Neural Transmission
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