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Functional assessment

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https://www.readbyqxmd.com/read/28551930/-laboratory-tests-and-radiological-imaging-diagnostic-tools-that-share-information-and-can-be-functionally-integrated
#1
Michael Mayer
In spite of apparent disparity between the specialties of radiological imaging, pathology and laboratory analysis, the medical diagnostic information that these sources provide have a lot in common and can be effectively utilized by sharing quantitative and qualitative results through modern information technology processes. Informaticsbased integration of radiological imaging, digital images of anatomical and molecular pathology and clinical laboratory results enables earlier, more sensitive and precise diagnosis, resulting in the more efficient treatment of patients...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551877/loss-of-gait-control-assessed-by-cognitive-motor-dual-tasks-pros-and-cons-in-detecting-people-at-risk-of-developing-alzheimer-s-and-parkinson-s-diseases
#2
REVIEW
Maroua Belghali, Nathalie Chastan, Fabien Cignetti, Damien Davenne, Leslie M Decker
Alzheimer's and Parkinson's diseases are age-related progressive neurodegenerative diseases of increasing prevalence worldwide. In the absence of curative therapy, current research is interested in prevention, by identifying subtle signs of early-stage neurodegeneration. Today, the field of behavioral neuroscience has emerged as one of the most promising areas of research on this topic. Recently, it has been shown that the exacerbation of gait disorders under dual-task conditions (i.e., simultaneous performance of cognitive and motor tasks) could be a characteristic feature of Alzheimer's and Parkinson's diseases...
May 27, 2017: GeroScience
https://www.readbyqxmd.com/read/28551835/measurement-of-quality-of-life-and-attitudes-towards-illness-in-children-and-young-people-with-chronic-kidney-disease
#3
Jennifer Heath, Paul Norman, Martin Christian, Alan Watson
PURPOSE: Chronic kidney disease (CKD) can place restrictions upon biopsychosocial development in children; consequently, assessment of self-reported quality of life (QoL) is important in patient evaluations. This research aimed to evaluate a generic and renal-specific self-report QoL scale, assess children's attitudes towards living with CKD and propose an appropriate tool for future individual clinical use or departmental audit. METHODS: Seventy-one children (41 male, 30 female; mean age = 13...
May 27, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28551788/functional-role-of-mitochondria-in-arrhythmogenesis
#4
Jessica Gambardella, Daniela Sorriento, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Luigi Napolitano, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli
Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551779/functional-implications-of-cardiac-mitochondria-clustering
#5
Felix T Kurz, Miguel A Aon, Brian O'Rourke, Antonis A Armoundas
The spatio-temporal organization of mitochondria in cardiac myocytes facilitates myocyte-wide, cluster-bound, mitochondrial inner membrane potential oscillatory depolarizations, commonly triggered by metabolic or oxidative stressors. Local intermitochondrial coupling can be mediated by reactive oxygen species (ROS) that activate inner membrane pores to initiate a ROS-induced-ROS-release process that produces synchronized limit cycle oscillations of mitochondrial clusters within the whole mitochondrial network...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551777/large-scale-functional-neural-network-correlates-of-response-inhibition-an-fmri-meta-analysis
#6
Ruibin Zhang, Xiujuan Geng, Tatia M C Lee
An influential hypothesis from the last decade proposed that regions within the right inferior frontal cortex of the human brain were dedicated to supporting response inhibition. There is growing evidence, however, to support an alternative model, which proposes that neural areas associated with specific inhibitory control tasks co-exist as common network mechanisms, supporting diverse cognitive processes. This meta-analysis of 225 studies comprising 323 experiments examined the common and distinct neural correlates of cognitive processes for response inhibition, namely interference resolution, action withholding, and action cancellation...
May 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28551724/the-rate-of-adherence-to-urate-lowering-therapy-and-associated-factors-in-chinese-gout-patients-a-cross-sectional-study
#7
Rulan Yin, Haixia Cao, Ting Fu, Qiuxiang Zhang, Lijuan Zhang, Liren Li, Zhifeng Gu
The aim of this study was to assess adherence rate and predictors of non-adherence with urate-lowering therapy (ULT) in Chinese gout patients. A cross-sectional study was administered to 125 gout patients using the Compliance Questionnaire on Rheumatology (CQR) for adherence to ULT. Patients were asked to complete the Treatment Satisfaction Questionnaire for Medication version II, Health Assessment Questionnaire, Confidence in Gout Treatment Questionnaire, Gout Knowledge Questionnaire, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and 36-Item Short Form Health Survey...
May 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28551578/toxicity-of-organic-uv-filters-to-the-aquatic-midge-chironomus-riparius
#8
Diana Campos, Carlos Gravato, Carla Quintaneiro, Oksana Golovko, Vladimír Žlábek, Amadeu M V M Soares, João L T Pestana
Despite the frequent detection of organic ultraviolet-filters (UV-filters) in freshwater sediments, there is a lack of ecotoxicological data undermining a correct risk assessment for these emerging contaminants. The present study assessed the effects of three of the most commonly used UV-filters (benzophenone-3 - BP3; 3-(4-methylbenzylidene)camphor - 4-MBC and octocrylene - OC) on Chironomus riparius life history and biochemical responses. Standard ecotoxicological assays confirmed that all compounds impaired growth of C...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551511/the-effects-of-foot-cooling-on-postural-muscle-responses-to-an-unexpected-loss-of-balance
#9
Oran W Ferguson, Nadia Polskaia, Craig D Tokuno
The purpose of this study was to examine the role of foot sole somatosensory information during reactive postural control. Twenty young adults (22.0±1.4y) participated in this study. Baseline skin sensitivity from the foot sole was assessed using Semmes-Weinstein monofilaments. Postural muscle responses, in the form of electromyographic (EMG) onset latencies and amplitudes, were then obtained while participants recovered their balance while standing on a moveable platform that could translate in either the forward or backward direction...
May 25, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28551479/dna-and-protein-binding-double-strand-dna-cleavage-and-cytotoxicity-of-mixed-ligand-copper-ii-complexes-of-the-antibacterial-drug-nalidixic-acid
#10
Rangasamy Loganathan, Mani Ganeshpandian, Nattamai S P Bhuvanesh, Mallayan Palaniandavar, Amsaveni Muruganantham, Swapan K Ghosh, Anvarbatcha Riyasdeen, Mohammad Abdulkader Akbarsha
The water soluble mixed ligand complexes [Cu(nal)(diimine)(H2O)](ClO4) 1-4, where H(nal) is nalidixic acid and diimine is 2,2'-bipyridine (1), 1,10-phenanthroline (2), 5,6-dimethyl-1,10-phenanthroline (3), and 3,4,7,8-tetramethyl-1,10-phenanthroline (4), have been isolated. The coordination geometry around Cu(II) in 1 and that in the Density Functional Theory optimized structures of 1-4 has been assessed as square pyramidal. The trend in DNA binding constants (Kb) determined using absorption spectral titration (Kb: 1, 0...
May 3, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28551445/decreasing-post-operative-narcotics-in-reconstructive-pelvic-surgery-a-randomized-controlled-trial
#11
Krista Ml Reagan, David M O'Sullivan, Richard Gannon, Adam C Steinberg
BACKGROUND: Post-operative pain control is crucial to any successful recovery plan. Many currently used medication regimens are narcotic-focused. OBJECTIVE: The objective of our study was to evaluate the efficacy of a multi-modal pain regimen after pelvic reconstructive surgery. STUDY DESIGN: The primary outcome measure was narcotic use. Secondary outcomes included pain, nausea and constipation. Patients were randomized to either a "usual care" post-operative treatment regimen or a multimodal pain regimen...
May 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28551444/effect-of-prior-focal-therapy-on-perioperative-oncologic-and-functional-outcomes-of-salvage-robotic-assisted-radical-prostatectomy
#12
Igor Nunes-Silva, Eric Barret, Victor Srougi, Mohammed Baghdadi, Paolo Capogrosso, Silvia Garcia-Barreras, Solange Kanso, Rafael Tourinho-Barbosa, Ariê Carneiro, Rafael Sanchez-Salas, François Rozet, Marc Galiano, Xavier Cathelineau
PURPOSE: To assess the impact of focal therapy (FT) on perioperative, oncologic, and functional outcomes in men who underwent salvage robotic-assisted radical prostatectomy(S-RARP) compared to primary RARP (P-RARP). MATERIALS AND METHODS: FT was performed in patients presenting Gleason score 3+3 or 3+4, clinical stage ≤cT2a, serum prostate-specific antigen(PSA) ≤15ng/ml, unilateral positive biopsy, maximum length of any positive core <10mm and life expectancy >10 years...
May 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28551436/effect-of-stiffness-of-chitosan-hyaluronic-acid-dialdehyde-hydrogels-on-the-viability-and-growth-of-encapsulated-chondrocytes
#13
Lynda V Thomas, Rahul Vg, Prabha D Nair
Substrate elasticity or stiffness can influence the phenotypic and functional characteristics of chondrocytes. This work aimed to study the effect of varying stiffness compositions of a two-component injectable hydrogel based on chitosan (CH) and oxidized hyaluronic acid (HDA) on the growth and functionality of encapsulated chondrocytes. Three different ratios of the gel were prepared (10:1,10:3 and 10:5 CH-HDA) and characterized. The stiffness of the gels was evaluated from the force displacement curves using force spectroscopy AFM analysis...
May 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28551433/elucidation-of-microbial-characterization-of-aerobic-granules-in-a-sequencing-batch-reactor-performing-simultaneous-nitrification-denitrification-and-phosphorus-removal-at-varying-carbon-to-phosphorus-ratios
#14
Qiulai He, Jun Zhou, Qun Song, Wei Zhang, Hongyu Wang, Li Liu
An aerobic granules simultaneous nitrification, denitrification and phosphorus removal (SNDPR) system was evaluated in terms of the reactor performance and microbial population dynamics with decreasing C/P ratios from 50 to 16. The effects of C/P ratios on organic carbon and nutrients removal were investigated, as well as the alpha diversity of the bacterial community and bacterial compositions by using Illumina MiSeq pyrosequencing technology. Finally, the relative abundances and distribution patterns were identified and assessed given the key functional groups involved in biological nutrients removals to reveal the effects of C/P ratios to aerobic granules in the SNDPR from the molecular level...
May 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28551430/exercise-training-improves-physical-function-and-fitness-in-long-term-paediatric-brain-tumour-survivors-treated-with-cranial-irradiation
#15
P J Piscione, E Bouffet, B Timmons, K S Courneya, D Tetzlaff, J E Schneiderman, C B de Medeiros, U Bartels, D J Mabbott
AIMS: We examined the efficacy of exercise training for improving physical functioning and cardiopulmonary fitness in survivors of paediatric brain tumours (BTs) treated with cranial irradiation. METHODS: We conducted a controlled clinical trial with crossover of exercise training versus no training in the community in either a group or combined group/home setting. A volunteer sample of 28 children treated with cranial irradiation for brain tumours completed training (mean age = 11...
May 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28551359/previous-radiotherapy-and-the-clinical-activity-and-toxicity-of-pembrolizumab-in-the-treatment-of-non-small-cell-lung-cancer-a-secondary-analysis-of-the-keynote-001-phase-1-trial
#16
Narek Shaverdian, Aaron E Lisberg, Krikor Bornazyan, Darlene Veruttipong, Jonathan W Goldman, Silvia C Formenti, Edward B Garon, Percy Lee
BACKGROUND: Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. METHODS: We assessed patients with advanced NSCLC treated on the phase 1 KEYNOTE-001 trial at a single institution (University of California, Los Angeles, CA, USA). Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or less, had adequate organ function, and no history of pneumonitis...
May 24, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28551353/the-role-of-interleukin-1%C3%AE-as-a-predictive-biomarker-and-potential-therapeutic-target-during-clinical-ex-vivo-lung-perfusion
#17
Anders S I Andreasson, Lee A Borthwick, Colin Gillespie, Kasim Jiwa, Jonathan Scott, Paul Henderson, Jonny Mayes, Rosalba Romano, Marius Roman, Simi Ali, James E Fildes, Nandor Marczin, John H Dark, Andrew J Fisher
BACKGROUND: Extended criteria donor lungs deemed unsuitable for immediate transplantation can be reconditioned using ex vivo lung perfusion (EVLP). Objective identification of which donor lungs can be successfully reconditioned and will function well post-operatively has not been established. This study assessed the predictive value of markers of inflammation and tissue injury in donor lungs undergoing EVLP as part of the DEVELOP-UK study. METHODS: Longitudinal samples of perfusate, bronchoalveolar lavage, and tissue from 42 human donor lungs undergoing clinical EVLP assessments were analyzed for markers of inflammation and tissue injury...
May 12, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28551264/quercetin-and-related-flavonoids-conserve-their-antioxidant-properties-despite-undergoing-chemical-or-enzymatic-oxidation
#18
Elías Atala, Jocelyn Fuentes, María José Wehrhahn, Hernán Speisky
Oxidation of a phenolic group in quercetin is assumed to compromise its antioxidant properties. To address this assumption, the ROS-scavenging, Folin-Ciocalteau- and Fe-reducing capacities of quercetin and thirteen structurally related flavonoids were assessed and compared with those of mixtures of metabolites resulting from their chemical and enzymatic oxidation. Regardless of the oxidation mode, the metabolites mixtures largely conserved the antioxidant properties of the parent molecules. For quercetin, 95% of its ROS-scavenging and over 77% of its Folin-Ciocalteau- and Fe-reducing capacities were retained...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551241/structure-characterization-and-antioxidant-activity-of-polysaccharides-from-chinese-quince-seed-meal
#19
Li Wang, Hua-Min Liu, Guang-Yong Qin
In the present study, three polysaccharide fractions, QSMP-1, QSMP-2, and QSMP-3, were isolated and purified from the seed meal of Chinese quince. These fractions' structures were investigated by high performance anion exchange chromatography (HPAEC), gel permeation chromatography (GPC), Fourier transform infrared (FT-IR), and nuclear magnetic resonance (NMR), and their antioxidant activities were assessed. The results showed that QSMP-1 is a novel polysaccharide with a backbone mainly composed of →4)-Glcp-(1→, →6)-Glcp-(1→, →6)-Galp-(1→, →2, 3, 4)-Xylp-(1→...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551192/differences-in-liver-functionality-indexes-in-peripartal-dairy-cows-fed-rumen-protected-methionine-or-choline-are-associated-with-performance-oxidative-stress-status-and-plasma-amino-acid-profiles
#20
Z Zhou, E Trevisi, D N Luchini, J J Loor
The liver functionality index (LFI) represents an assessment of transition cow metabolic health by measuring changes in biomarkers associated with liver plasma protein synthesis (albumin), lipoprotein synthesis (cholesterol), and heme catabolism (bilirubin). The present analysis was conducted to determine the role of peripartal rumen-protected Met or choline (CHOL) supplementation on LFI groupings, and to assess relationships with performance, inflammation, oxidative stress status, and plasma AA profiles. A cohort of 40 multiparous Holstein cows that were part of a randomized complete block design with 2 × 2 factorial arrangement of Met (Smartamine M, Adisseo NA, Alpharetta, GA) and CHOL (ReaShure, Balchem Inc...
May 24, 2017: Journal of Dairy Science
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