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https://www.readbyqxmd.com/read/28944999/systemic-redistribution-of-the-intramyocardially-injected-mesenchymal-stem-cells-by-repeated-remote-ischaemic-post-conditioning
#1
Qin Jiang, Tao Yu, Keli Huang, Hao Zhang, Zhe Zheng, Shengshou Hu
We investigated the effect of repeated remote ischaemic post-conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague-Dawley rats was induced by 30-min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5-min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell-derived factor-1 alpha (SDF-1α) was consistently induced by repeated RIPoC procedures...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#2
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28944896/microrna%C3%A2-186-targets-igf%C3%A2-1r-and-exerts-tumor%C3%A2-suppressing-functions-in-glioma
#3
Jian Jiang, Weijie Wang, Dazhao Fang, Xiaodong Jin, Lianshu Ding, Xiaoyang Sun
Glioma is the most common malignant brain tumor in adults and represents one of the most aggressive and life‑threatening types of cancer in humans. Increasing studies have revealed that microRNAs are abnormally expressed in various types of human cancer, and have oncogenic or tumor suppressive roles, which depend primarily on the type of cancer. The present study aimed to investigate the expression level and effects of microRNA‑186 (miR‑186) on glioma, and its underlying molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was performed to detect the expression of miR‑186 in glioma tissues and cell lines...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944877/sparcl1-suppresses-cell-migration-and-invasion-in-renal-cell-carcinoma
#4
Hui Ye, Wei-Gang Wang, Jun Cao, Xi-Chun Hu
Previous studies have shown that the human SPARC‑like 1 (SPARCL1) is crucial for human cancer migration and invasion. In the present study, the expression, biological function and possible molecular regulatory mechanisms of SPARCL1 were investigated in human renal cell carcinoma (RCC). The protein expression of SPARCL1 in cells was evaluated using western blot analysis and immunohistochemical staining in the tissue microarray. The effects of SPARCL1 on the biological behaviors of RCC cells were assessed using in vitro assays...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944872/isoflurane-exposure-regulates-the-cell-viability-and-bdnf-expression-of-astrocytes-via-upregulation-of-trek%C3%A2-1
#5
Cui-Hong Zhou, Ya-Hong Zhang, Fen Xue, Shan-Shan Xue, Yun-Chun Chen, Ting Gu, Zheng-Wu Peng, Hua-Ning Wang
Neonatal isoflurane exposure in rodents disrupts hippocampal cognitive functions, including learning and memory, and astrocytes may have an important role in this process. However, the molecular mechanisms underlying this disruption are not fully understood. The present study investigated the role of TWIK‑related K+ channel (TREK‑1) in isoflurane‑induced cognitive impairment. Lentiviruses were used to overexpress or knockdown TREK‑1 in astrocytes exposed to increasing concentrations of isoflurane or O2 for 2 h...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944833/low-doses-of-co-nanoparticles-induce-death-and-regulate-osteogenic-differentiation-in-mg%C3%A2-63-cells
#6
Qinglin Han, Fan Liu
The aim of the present study was to investigate the effects of cobalt nanoparticles (CoNPs) on the proliferation and differentiation of human osteoblasts in vitro, and to investigate the molecular mechanisms via which CoNPs affect proliferation and differentiation of osteoblasts. The MG‑63 human osteoblast cell line was treated with different concentrations of CoNPs for 12 to 48 h in vitro. At each time point, cell morphology was observed and an MTT assay was performed to assess cell viability. Alkaline phosphatase (ALP), osteocalcin (BGLAP), collagen I (COL I), osteoprotegerin (OPG) and receptor activator of nuclear factor κ‑B ligand mRNA expression levels, and ALP, BGLAP and COL protein expression levels, were assessed by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944766/magnesium-oxide-nanoparticle-loaded-polycaprolactone-composite-electrospun-fiber-scaffolds-for-bone-soft-tissue-engineering-applications-in-vitro-and-in-vivo-evaluation
#7
Ajay Suryavanshi, Kunal Khanna, K R Sindhu, Jayesh Bellare, Rohit Srivastava
The objective of the present investigation was to assess the potential of magnesium oxide nanoparticle (MgO NP)-loaded electrospun polycaprolactone (PCL) polymer composites as a bone-soft tissue engineering scaffold. MgO NPs were synthesized using a hydroxide precipitation sol-gel method and characterized using field emission gun-scanning electron microscopy/energy-dispersive x-ray spectroscopy (FEG-SEM/EDS), field emission gun-transmission electron microscopy (FEG-TEM), and x-ray diffraction (XRD) analysis...
September 25, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#8
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944699/compiling-standardized-information-from-clinical-practice-using-content-analysis-and-icf-linking-rules-in-a-goal-oriented-youth-rehabilitation-program
#9
Nadia A Lustenberger, Birgit Prodinger, Delgerjargal Dorjbal, Sara Rubinelli, Klaus Schmitt, Anke Scheel-Sailer
PURPOSE: To illustrate how routinely written narrative admission and discharge reports of a rehabilitation program for eight youths with chronic neurological health conditions can be transformed to the International Classification of Functioning, Disability and Health. METHODS: First, a qualitative content analysis was conducted by building meaningful units with text segments assigned of the reports to the five elements of the Rehab-Cycle(®): goal; assessment; assignment; intervention; evaluation...
September 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28944697/influence-of-trunk-control-and-lower-extremity-impairments-on-gait-capacity-in-children-with-cerebral-palsy
#10
Julia Balzer, Petra Marsico, Elena Mitteregger, Marietta L van der Linden, Thomas H Mercer, Hubertus J A van Hedel
PURPOSE: We investigated the combined impact of trunk control and lower extremities impairments on predicting gait capacity in children with cerebral palsy (CP) and evaluated relationships between trunk control and lower extremities impairments. METHODS: Data of 52 children with CP [29 boys, mean age 11 years 9 months (±4 years 6 months)] were included in this observational study. Gait capacity was measured by the "modified Time Up and Go test". Experienced therapists performed the "Modified Ashworth Scale", "Manual Muscle Test", the "Selective Control Assessment of the Lower Extremity", and the "Trunk Control Measurement Scale"...
September 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28944644/effects-of-resistance-training-on-the-physical-condition-of-people-with-multiple-sclerosis
#11
Felipe J Aidar, André L Carneiro, Osvaldo Costa Moreira, Cláudia E Patrocínio de Oliveira, Nuno D Garrido, Victor Machado Reis, Igor Raineh, José M Vilaça, Dihogo Gama de Matos
OBJECTIVE: This study aimed to evaluate the effect of resistance training on the functional capacity of people with multiple sclerosis. SETTING: Two groups were defined intentionally and divided based on the Expanded Disability Status Scale (EDSS): an experimental group (EG) consisting of 11 individuals, 18.2% with an EDSS Score of 0 - 3.0, 72.8% with a score of 3.5 - 5.5 and 9.1% with a score of 6.0 - 7.5; and a control group (CG) consisting of 12 subjects, 25...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944626/caveolin-1-secreted-from-adipose-tissues-and-adipocytes-functions-as-an-adipogenesis-enhancer
#12
Chia-Chu Chang, Chen-Yu Chen, Hui-Chin Wen, Chih-Yang Huang, Ming-Shiu Hung, Hsi-Chi Lu, Woan-Ling Chen, Chung-Ho Chang
OBJECTIVE: Caveolin-1 (Cav-1) is expressed abundantly in adipose tissue and involved in many physiological processes. While Cav-1 has been reported to be secreted in pancreatic acinar cells and LNCaP prostate cancer cells, its secretion from adipose tissue awaits investigation. METHODS: Cav-1 secretion from 3T3-L1 adipocytes and fat tissues from normal chow diet- and high-fat diet (HFD)-fed mice was measured. Functions and uptake of secreted Cav-1 proteins were assessed by adding Cav-1 back to preadipocytes and LNCaP cells...
September 25, 2017: Obesity
https://www.readbyqxmd.com/read/28944616/time-course-of-the-changes-in-right-and-left-ventricle-function-and-associated-factors-after-transcatheter-closure-of-atrial-septal-defects
#13
Byung W Yoo, Jung O Kim, Lucy Y Eun, Jae Y Choi, Dong S Kim
OBJECTIVE: The purpose of this study was to evaluate the changes in right ventricle (RV) and left ventricle (LV) function after transcatheter atrial septal defect (ASD) closure and to assess the influence of the age and the amount of shunt. DESIGN: Retrospective study PATIENTS: Fifty-three adult patients who underwent transcatheter closure were enrolled, then divided into subgroups according to the age (< 40 years vs ≥ 40 years), and the amount of shunt flow (QpQs < 2...
September 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28944610/last-century-forest-productivity-in-a-managed-dry-edge-scots-pine-population-the-two-sides-of-climate-warming
#14
Laura Marqués, Jaime Madrigal-González, Miguel A Zavala, J Julio Camarero, Florian Hartig
Climate change in the Mediterranean, associated with warmer temperatures and more frequent droughts, is expected to impact forest productivity and the functioning of forests ecosystems as carbon reservoirs in the region. Climate warming can positively affect forest growth by extending the growing season, whereas increasing summer drought generally reduces forest productivity and may cause growth decline, trigger dieback, hamper regeneration and increase mortality. Forest management could potentially counteract such negative effects by reducing stand density and thereby competition for water...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944553/outcomes-for-bipolar-patients-assessed-in-the-french-expert-center-network-a-2-year-follow-up-observational-study-fondamental-advanced-centers-of-expertise-for-bipolar-disorder-face-bd
#15
Chantal Henry, Ophelia Godin, Philippe Courtet, Jean-Michel Azorin, Sébastien Gard, Frank Bellivier, Mircea Polosan, Jean-Pierre Kahn, Paul Roux, Valerie Aubin, Dominique Costagliola, Marion Leboyer, Bruno Etain
OBJECTIVE: A new health care system for patients with bipolar disorders was established in France under the auspices of Fondation FondaMental, based on thorough clinical assessment of patients and on close collaborations between expert centers and referring practitioners. We report the results of outcomes after 2 years of observational follow-up of adult patients assessed within the network. METHOD: A total of 984 patients were included in the study. We compared several parameters (e...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944474/altered-neural-oscillations-during-multisensory-integration-in-adolescents-with-fetal-alcohol-spectrum-disorder
#16
Alfredo D Bolaños, Brian A Coffman, Felicha T Candelaria-Cook, Piyadasa Kodituwakku, Julia M Stephen
BACKGROUND: Children with fetal alcohol spectrum disorder (FASD), who were exposed to alcohol in utero, display a broad range of sensory, cognitive, and behavioral deficits, which are broadly theorized to be rooted in altered brain function and structure. Based on the role of neural oscillations in multisensory integration from past studies, we hypothesized that adolescents with FASD would show a decrease in oscillatory power during event-related gamma oscillatory activity (30-100Hz), when compared to typically-developing healthy controls (HC), and that such decrease in oscillatory power would predict behavioral performance...
September 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28944453/personalised-digital-interventions-for-reducing-hazardous-and-harmful-alcohol-consumption-in-community-dwelling-populations
#17
REVIEW
Eileen Fs Kaner, Fiona R Beyer, Claire Garnett, David Crane, Jamie Brown, Colin Muirhead, James Redmore, Amy O'Donnell, James J Newham, Frank de Vocht, Matthew Hickman, Heather Brown, Gregory Maniatopoulos, Susan Michie
BACKGROUND: Excessive alcohol use contributes significantly to physical and psychological illness, injury and death, and a wide array of social harm in all age groups. A proven strategy for reducing excessive alcohol consumption levels is to offer a brief conversation-based intervention in primary care settings, but more recent technological innovations have enabled people to interact directly via computer, mobile device or smartphone with digital interventions designed to address problem alcohol consumption...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944358/ceramic-vs-composite-veneering-of-full-arch-implant-supported-zirconium-frameworks-assessing-patient-preference-and-satisfaction-a-crossover-double-blind-randomised-controlled-trial
#18
Mauro Merli, Eugenio Bianchini, Giorgia Mariotti, Marco Moscatelli, Matteo Piemontese, Giorgio Rappelli, Michele Nieri
PURPOSE: The objectives of this two-period, crossover, mono-centred, double-blind, randomised controlled trial (RCT) were to compare two different materials used for full arch implant-supported prosthetic restorations with regard to patient preference and impact on a patient's quality of life. MATERIALS AND METHODS: Edentulous patients requesting one full arch restoration in the mandible or maxilla supported by dental implants were included in this study. Patients were randomised to receive either a full arch zirconia framework hand-veneered with ceramic, or a full arch zirconia framework hand-veneered with composite material...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944355/wide-diameter-immediate-post-extractive-implants-vs-delayed-placement-of-normal-diameter-implants-in-preserved-sockets-in-the-molar-region-1-year-post-loading-outcome-of-a-randomised-controlled-trial
#19
Vittorio Checchi, Pietro Felice, Giovanni Zucchelli, Carlo Barausse, Maurizio Piattelli, Roberto Pistilli, Giovanni Grandi, Marco Esposito
PURPOSE: To compare the effectiveness of 6.0 to 8.0 mm-wide diameter implants, placed immediately after tooth extraction, with conventional 4.0 or 5.0 mm diameter implants placed in a preserved socket after a 4-month period of healing in the molar region. MATERIALS AND METHODS: Just after extraction of one or two molar teeth, and with no vertical loss of the buccal bone in relation to the palatal wall, 100 patients requiring immediate post-extractive implants were randomly allocated to immediate placement of one or two 6...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944354/single-vs-two-implant-retained-overdentures-for-edentulous-mandibles-a-systematic-review
#20
Ahmed Yaseen Alqutaibi, Marco Esposito, Radwan Algabri, Adnan Alfahad, Amal Kaddah, Mohammed Farouk, Ali Alsourori
PURPOSE: To compare prosthesis and implant failure, patient satisfaction, prosthetic complications and peri-implant marginal bone loss of mandibular overdentures (IOD) supported by a single or two implants. MATERIALS AND METHODS: Manual and electronic database (PubMed and Cochrane) searches were performed to identify randomised controlled trials, without language restriction, comparing single vs two implant supported mandibular overdentures. Two investigators extracted data independently...
2017: European Journal of Oral Implantology
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