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Volume kinetics

Justin Weinberg, Shaojie Zhang, Gillian Crews, Giorgio Carta, Todd Przybycien
Chemical modification of Protein A (ProA) chromatography ligands with polyethylene glycol (PEGylation) has been proposed as a strategy to increase the process selectivity and resin robustness by providing the ligand with a steric repulsion barrier against non-specific binding. This article comprises a comprehensive study of IgG adsorption and transport in Repligen CaptivA PriMAB resin with PEGylated ProA ligands that are modified using 5.2 and 21.5 kDa PEG chains. We studied the impact of the molecular weight of the PEG as well as the extent of PEGylation for the 5...
March 9, 2018: Journal of Chromatography. A
Song Cheng, Libo Zhang, Aiyuan Ma, Hongying Xia, Jinhui Peng, Chunyang Li, Jianhua Shu
The methylene blue (MB) removal abilities of raw activated carbon and iron/cerium modified raw activated carbon (Fe-Ce-AC) by adsorption were researched and compared. The characteristics of Fe-Ce-AC were examined by N2 adsorption, zeta potential measurement, FTIR, Raman, XRD, XPS, SEM and EDS. After modification, the following phenomena occurred: The BET surface area, average pore diameter and total pore volume decreased; the degree of graphitization also decreased. Moreover, the presence of Fe3 O4 led to Fe-Ce-AC having magnetic properties, which makes it easy to separate from dye wastewater in an external magnetic field and subsequently recycle...
March 2018: Journal of Environmental Sciences (China)
Wenjiao Ren, Liqiang Xu, Lin Zhu, Xinye Wang, Xiaojian Ma, Debao Wang
Lithium-sulfur (Li-S) battery has attracted increasing attention owning to its high energy density and the abundance of sulfur. However, its commercialization is still restricted owing to the low conductivity of sulfur, large volume expansion and severe polysulfide-shuttle effect. To address these problems, here we reported a simple template-free solvothermal method combined with subsequent calcination method to prepare cobalt-doped VN yolk-shell nanospheres encapsulated in thin layer of nitrogen-doped carbon (Co-VN@C) composite as an ideal sulfur hosts for the first time...
March 16, 2018: ACS Applied Materials & Interfaces
Victor Kamoen, Milad El Haddad, Marc De Buyzere, Tine De Backer, Frank Timmermans
AIMS: We recently reported the feasibility of the average pixel intensity (API) method for grading mitral regurgitation (MR) in a heterogeneous MR population. Since mitral valve prolapse (MVP) is an important cause of primary MR, we more specifically investigated the feasibility of the API method and the MR flow dynamics in patients with MVP. METHODS: Transthoracic echocardiography was performed by a single operator in consecutive MVP patients (n=112). MR was assessed using the API method, color Doppler, vena contracta width (VCW), effective regurgitant orifice area (PISA-EROA) and regurgitant volume (PISA-RV)...
May 1, 2018: International Journal of Cardiology
Kambiz Rahbar, Ali Afshar-Oromieh, Martin Bögemann, Stefan Wagner, Michael Schäfers, Lars Stegger, Matthias Weckesser
PURPOSE: PSMA-targeted PET in patients with prostate cancer (PCa) has a significant impact on treatment decisions. By far the most frequently used PSMA ligand is68 Ga-labelled PSMA-11. However, due to the availability of larger amounts of activity,18 F-labelled PSMA ligands are of major interest. The aim of the present study was to evaluate the biodistribution and performance of the novel18 F-labelled ligand PSMA-1007 at two different time points. METHODS: This retrospective analysis included 40 consecutive patients (mean age 68...
March 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Daniele Missio, Natália Picolli Folchini, Fabio Gallas Leivas, Cecília Isabel Inês Urquiza Machado Pavin, Hirya Fernandes Pinto, Francielli Weber Santos Cibin, Daniela Dos Santos Brum
The aim of the present study was to evaluate the effects of Percoll volume on recovery rate, sperm quality, and embryo development kinetics in in vitro production of cattle embryos. Straws of conventional and sex-sorted semen were allocated to three different volumes of Percoll: 300 μL of each Percoll gradient (90%, 60%, and 30%), Control; 100 μL of each Percoll gradient, P100; and 200 μL of each Percoll gradient, P200. Sperm quality, fertilization rate, and embryo morpho-kinetic development using time lapse cinematography up to 48 h post-insemination were evaluated...
March 4, 2018: Animal Reproduction Science
Olga Francisco, Ifeoluwa Idowu, Kelsey L Friesen, Matthew McDougall, Sara Seoin Choi, Patrique Bolluch, Oluwadamilola Daramola, Wesley Johnson, Vince Palace, Jörg Stetefeld, Gregg T Tomy
The efficacy of a lightly cross-linked polymeric bead to absorb polycyclic aromatic hydrocarbons (PAHs) from the surface of fresh- and salt-water in a simulated oil-spill scenario was assessed in this study. A layer of PAHs at the water surface was created by first preparing the PAHs in hexane and then carefully spiking this mixture onto the surface of water. Beads were then applied to the surface of the organic phase and the amount of hydrocarbons absorbed by the beads was examined at prescribed time intervals and at different temperatures...
March 5, 2018: Chemosphere
Hitomi Mukaibo, Tonghui Wang, Victor H Perez-Gonzalez, Jirachai Getpreecharsawas, Jack T Wurzer, Blanca Lapizco-Encinas, James L McGrath
Insulator-based dielectrophoresis (iDEP) is a simple, scalable mechanism that can be used for directly manipulating particle trajectories in pore-based filtration and separation processes. However, iDEP manipulation of nanoparticles presents unique challenges as the dielectrophoretic force (<b><i>F</i></b><sub>DEP</sub>) exerted on the nanoparticles can easily be overshadowed by opposing kinetic forces. In this study, a molecularly thin, SiN-based nanoporous membrane (NPN) is explored as a breakthrough technology that enhances <b><i>F</i></b><sub>DEP</sub>...
March 12, 2018: Nanotechnology
Yuesheng Shen, Wenjin Zhu, Mengye Zhao, Guige Zhao, Geng Niu, Yuwei Bai, Bo Yang, Chao Chen, Hongli Zhu
Polymerized porcine hemoglobin (pPolyHb), a kind of glutaraldehyde-polymerized haemoglobin-based oxygen carrier, was developed as a potential red blood substitute for clinical applications. Assessment of its absorption, distribution, and metabolism is a major determinant of its safety and efficacy. In this study, a series of pharmacokinetic parameters of pPolyHb were measured and calculated in different animal models, such as the top-load model, the 50% exchange transfusion model and the haemorrhagic shock model...
March 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yo Han Kwon, Krysten Minnici, Jung Jin Park, Sujin R Lee, Guoyan Zhang, Esther S Takeuchi, Kenneth J Takeuchi, Amy C Marschilok, Elsa Reichmanis
Conjugated polymers possessing polar functionalities were shown to effectively anchor single-walled carbon nanotubes (SWNTs) to the surface of high-capacity anode materials, and enable the formation of electrical networks. Specifically, poly[3-(potassium-4-butanoate) thiophene] (PPBT) served as a bridge between SWNT networks and various anode materials, including monodispersed Fe3O4 spheres (sFe3O4), and silicon nanoparticles (Si NPs). The PPBT π‒conjugated backbone and carboxylate (COO‒) substituted alkyl side chains, respectively, attracted the SWNT π‒electron surface and chemically interacted with active material surface hydroxyl (‒OH) species to form a carboxylate bond...
March 10, 2018: Journal of the American Chemical Society
Mohsen Ghafari, John D Atkinson
A novel one-step hyper-cross-linking method, using 1,2-dichloroethane (DCE) and 1,6-dichlorohexane (DCH) cross-linkers, expands the micropore volume of commercial styrenic polymers. Performance of virgin and modified polymers was evaluated by measuring hexane, toluene, and methyl-ethyl-ketone (MEK) adsorption capacity, adsorption/desorption kinetics, and desorption efficiency. Hyper-cross-linked polymers have up to 128% higher adsorption capacity than virgin polymers at P/P0  = 0.05 due to micropore volume increases up to 330%...
February 27, 2018: Journal of Hazardous Materials
Hossein Hosseinzadeh, Sonia Ramin
In the present work, a novel magnetic chitosan/graphene oxide nanocomposite (MCGON) was synthesized for the removal of Cu2+ from aqueous solutions. The adsorbent was composed of graphene oxide (GO) modified by ethylenediamine (ED), Fe3 O4 nanoparticles and chitosan-g-poly(acrylic acid-co-2-acrylamido-2-methylpropane sulfonic acid) copolymer. The composition and structure of adsorbents were characterized by FTIR, SEM, EDX, XRD, TGA, VSM and BET analysis. The magnetic MCGON with a high specific surface area of (132...
March 7, 2018: International Journal of Biological Macromolecules
Zhen Fan, Melanie Dani, Grazia D Femminella, Melanie Wood, Valeria Calsolaro, Mattia Veronese, Federico Turkheimer, Steve Gentleman, David J Brooks, Rainer Hinz, Paul Edison
PURPOSE: Neuroinflammation and microglial activation play an important role in amnestic mild cognitive impairment (MCI) and Alzheimer's disease. In this study, we investigated the spatial distribution of neuroinflammation in MCI subjects, using spectral analysis (SA) to generate parametric maps and quantify11 C-PBR28 PET, and compared these with compartmental and other kinetic models of quantification. METHODS: Thirteen MCI and nine healthy controls were enrolled in this study...
March 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Robin J Tyacke, Jim F M Myers, Ashwin Venkataraman, Inge Mick, Samuel Turton, Jan Passchier, Stephen M Husbands, Eugenii Ilan A Rabiner, Roger N Gunn, Philip S Murphy, Christine A Parker, David J Nutt
The imidazoline2 binding site (I2 BS), are thought to be expressed in glia, and implicated in the regulation of glial fibrillary acidic protein. A PET ligand for this target would be important for the investigation of neurodegenerative and neuroinflammatory diseases.11 C-BU99008 has previously been identified as a putative PET radioligand. Here we present the first in vivo characterisation of this PET radioligand in humans and assess its test-retest reproducibility. Methods 14 healthy male volunteers underwent dynamic PET imaging with11 C-BU99008 and arterial sampling...
March 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Gang Liu, Wen Xie, Guobing Wei, Yan Yang, Junwei Liu, Tiancai Xu, Weidong Xie, Xiaodong Peng
The hot deformation and dynamic recrystallization behavior of the dual-phase Mg-9Li-3Al-2Sr-2Y alloy had been investigated using a compression test. The typical dual-phase structure was observed, and average of grain size of as-homogenized alloy is about 110 µm. It mainly contains β-Li, α-Mg, Al₄Sr and Al₂Y phases. The dynamic recrystallization (DRX) kinetic was established based on an Avrami type equation. The onset of the DRX process occurred before the peak of the stress-strain flow curves. It shows that the DRX volume fraction increases with increasing deformation temperature or decreasing strain rate...
March 9, 2018: Materials
Ross D Pollock, Katie A O'Brien, Lorna J Daniels, Kathrine B Nielsen, Anthea Rowlerson, Niharika A Duggal, Norman R Lazarus, Janet M Lord, Andrew Philp, Stephen D R Harridge
In this study, results are reported from the analyses of vastus lateralis muscle biopsy samples obtained from a subset (n = 90) of 125 previously phenotyped, highly active male and female cyclists aged 55-79 years in regard to age. We then subsequently attempted to uncover associations between the findings in muscle and in vivo physiological functions. Muscle fibre type and composition (ATPase histochemistry), size (morphometry), capillary density (immunohistochemistry) and mitochondrial protein content (Western blot) in relation to age were determined in the biopsy specimens...
March 8, 2018: Aging Cell
Federico Canè, Benedict Verhegghe, Matthieu De Beule, Philippe B Bertrand, Rob J Van der Geest, Patrick Segers, Gianluca De Santis
With cardiovascular disease (CVD) remaining the primary cause of death worldwide, early detection of CVDs becomes essential. The intracardiac flow is an important component of ventricular function, motion kinetics, wash-out of ventricular chambers, and ventricular energetics. Coupling between Computational Fluid Dynamics (CFD) simulations and medical images can play a fundamental role in terms of patient-specific diagnostic tools. From a technical perspective, CFD simulations with moving boundaries could easily lead to negative volumes errors and the sudden failure of the simulation...
2018: BioMed Research International
Victoria M Stoll, Margaret Loudon, Jonatan Eriksson, Malenka M Bissell, Petter Dyverfeldt, Tino Ebbers, Saul G Myerson, Stefan Neubauer, Carl- Johan Carlhäll, Aaron T Hess
BACKGROUND: Quantification and visualisation of left ventricular (LV) blood flow is afforded by three-dimensional, time resolved phase contrast cardiovascular magnetic resonance (CMR 4D flow). However, few data exist upon the repeatability and variability of these parameters in a healthy population. We aimed to assess the repeatability and variability over time of LV 4D CMR flow measurements. METHODS: Forty five controls underwent CMR 4D flow data acquisition...
March 2, 2018: Journal of Cardiovascular Magnetic Resonance
P S Ghosh, K Ali, A Arya
Polymorphic transformations in LaPO4 are investigated as a function of pressure using density functional theory (DFT) based calculations under the generalized gradient approximation. The monazite-type (P21 /n) → barite-type (Pbnm) structural transformation is identified at 16.2 GPa and experimentally, no transformation is observed near this pressure. A discontinuity in the pressure-volume relation (of 4.16% volume discontinuity compared to the monazite structure at the same pressure) and unit-cell dimensions is observed around 28 GPa, which matches well with the previous experimental results...
March 2, 2018: Physical Chemistry Chemical Physics: PCCP
Tsugunosuke Masubuchi, Jan F Eckhard, Kathrin Lange, Bradley Visser, Martin Tschurl, Ulrich Heiz
A laser vaporization cluster source that has a room for cluster aggregation and a reactor volume, each equipped with a pulsed valve, is presented for the efficient gas-phase production of chemically modified metal clusters. The performance of the cluster source is evaluated through the production of Ta and Ta oxide cluster cations, Tax Oy + (y ≥ 0). It is demonstrated that the cluster source produces Tax Oy + over a wide mass range, the metal-to-oxygen ratio of which can easily be controlled by changing the pulse duration that influences the amount of reactant O2 introduced into the cluster source...
February 2018: Review of Scientific Instruments
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