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Volume kinetics

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https://www.readbyqxmd.com/read/28101733/3d-absorbed-dose-distribution-estimated-by-monte-carlo-simulation-in-radionuclide-therapy-with-a-monoclonal-antibody-targeting-synovial-sarcoma
#1
David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza, Anne-Laure Giraudet
BACKROUND: Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant (111)In-OTSA101 tumor uptake and favorable biodistribution, patient was randomly treated with 370/1110 MBq (90)Y-OTSA101. Monte Carlo-based 3D dosimetry integrating time-activity curves in VOI was performed on (111)In-OTSA101 repeated SPECT/CT. Estimated absorbed doses (AD) in normal tissues were compared to biological side effects and to the admitted maximal tolerated absorbed dose (MTD) in normal organs...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28096387/kinetic-assay-shows-that-increasing-red-cell-volume-could-be-a-treatment-for-sickle-cell-disease
#2
Quan Li, Eric R Henry, James Hofrichter, Jeffrey F Smith, Troy Cellmer, Emily B Dunkelberger, Belhu B Metaferia, Stacy Jones-Straehle, Sarah Boutom, Garrott W Christoph, Terri H Wakefield, Mary E Link, Dwayne Staton, Erica R Vass, Jeffery L Miller, Matthew M Hsieh, John F Tisdale, William A Eaton
Although it has been known for more than 60 years that the cause of sickle cell disease is polymerization of a hemoglobin mutant, hydroxyurea is the only drug approved for treatment by the US Food and Drug Administration. This drug, however, is only partially successful, and the discovery of additional drugs that inhibit fiber formation has been hampered by the lack of a sensitive and quantitative cellular assay. Here, we describe such a method in a 96-well plate format that is based on laser-induced polymerization in sickle trait cells and robust, automated image analysis to detect the precise time at which fibers distort ("sickle") the cells...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28093774/comparative-pharmacokinetics-of-diaveridine-in-pigs-and-chickens-following-single-intravenous-and-oral-administration
#3
Y-F Li, H-Y Guo, F Yang, L-G Zhou, X-H Huang, H-Z Ding, Z-L Zeng
Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10 mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t1/2β (elimination half-life) 0...
January 17, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28088096/mycelium-transformation-of-streptomyces-toxytricini-into-pellet-role-of-culture-conditions-and-kinetics
#4
Punit Kumar, Kashyap Kumar Dubey
The present study envisages the role of different carbon sources, nitrogen sources, metals, pH, inoculum volume and agitation rate in pellet formation of S. toxytricini at shake-flask level. It was found that galactose, ammonium sulphate, sodium nitrate, Cu(2+), Zn(2+), higher inoculum volume (5% v/v) and agitation rate at 300rpm caused significant reduction in pellet size (up to the range of 30μm-0.5mm) but biomass formations was also reduced subsequently. Interestingly diffused type of morphology was obtained in Fe(2+) supplemented medium with reduced biomass (1...
January 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28081001/how-assembly-matters-to-catalysis-and-thermal-conductivity-mediated-by-cuo-nanoparticles
#5
Ahmed Mohsen Ismail, Mahmoud Mohamed Emara, Taher Salah El Din Kassem, Mahmoud Ahmed Moussa
CuO nanostructures (NSs) of different morphologies were prepared, applied as catalysts for the pyrolysis of sugarcane bagasse (PSCB), and applied for thermally-conductive nanofluids. Both size and shape of the prepared NSs ranged from 5 to 1000 nm, and from nanodots (NDs) to spindle nano-aggregates (NAs), respectively. The catalytic activity of these NSs towards the PSCB was followed up by thermogravimetric analysis (TGA), where they increased the percentage of total weight loss, and lowered the decomposition temperatures of PSCB...
January 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28079222/infrared-characterisation-of-acetonitrile-and-propionitrile-aerosols-under-titan-s-atmospheric-conditions
#6
C Ennis, R Auchettl, M Ruzi, E G Robertson
Pure, crystalline acetonitrile (CH3CN) and propionitrile (CH3CH2CN) particles were formed in a collisional cooling cell allowing for infrared (IR) signatures to be compiled from 50 to 5000 cm(-1). The cell temperature and pressure conditions were controlled to simulate Titan's lower atmosphere (80-130 K and 1-100 mbar), allowing for the comparison of laboratory data to the spectra obtained from the Cassini-Huygens mission. The far-IR features confirmed the morphology of CH3CN aerosols as the metastable β-phase (monoclinic) ice, however, a specific crystalline phase for CH3CH2CN could not be verified...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28077032/iodine-responsive-poly-hema-pvp-hydrogel-for-self-regulating-burst-free-extended-release
#7
Jinku Xu, Peili Zhao, Yongchun Zhang
Swollen hydrogels with extended iodine release kinetics is highly desirable for burn and scald treatment. In this paper semi-interpenetrating poly(HEMA-PVP) hydrogels were prepared by radical polymerization followed by thermo-treatment to crosslink its PVP component. Incorporation of PVP component endows the hydrogels responsive to loaded iodine undergoing a reversible shrunken/swollen volume transition. This resulted in a self-regulating iodine release model, in which shrunken hydrogel at high iodine loading decreased drug diffusion thereby reducing burst release,, and then gradually swollen hydrogel as drug release ensures rapid release of dissociated drug from strong affinity sites on hydrogel backbone, achieving a burst-free extended release...
January 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28072384/impact-of-cerebellar-atrophy-on-cortical-gray-matter-and-cerebellar-peduncles-as-assessed-by-voxel-based-morphometry-and-high-angular-resolution-diffusion-imaging
#8
Michael Dayan, G Olivito, M Molinari, Mara Cercignani, Marco Bozzali, M Leggio
In recent years the cerebellum has been attributed amore important role in higher-level functions than previously believed. We examined a cohort of patients suffering from cerebellar atrophy resulting in ataxia, with two main objectives: first to investigate which regions of the cerebrum were affected by the cerebellar degeneration, and second to assess whether diffusion magnetic resonance imaging (dMRI) metrics within the medial (MCP) and superior cerebellar peduncle (SCP) - namely fractional anisotropy (FA) and radial diffusivity (RD) - could be used as a biomarker in patients with this condition...
October 2016: Functional Neurology
https://www.readbyqxmd.com/read/28069721/specific-inhibition-of-the-distribution-of-lobeglitazone-to-the-liver-by-atorvastatin-in-rats-evidence-for-an-roatp1b2-mediated-interaction-in-hepatic-transport
#9
Chang-Soon Yim, Yoo-Seong Jeong, Song-Yi Lee, Wonji Pyeon, Heon-Min Ryu, Jong-Hwa Lee, Kyeong-Ryoon Lee, Han-Joo Maeng, Suk-Jae Chung
CYP enzymes and hOATP1B1 are reported to be involved in the pharmacokinetics of lobeglitazone (LB), a new PPARγ agonist. Atorvastatin (ATV), a substrate for CYP3A and hOATP1B1, is likely to be co-administered with LB in patients with the metabolic syndrome. We report herein on a study of potential interactions between LB and ATV in rats. When LB was IV-administered with ATV, the systemic clearance (CL; 2.67 ± 0.63 mL/min/kg) and volume of distribution at steady-state (Vss; 289 ± 20 mL/kg) for LB remained unchanged, compared to those of LB without ATV (CL, 2...
January 9, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28068487/a-new-look-at-kinetics-in-relation-to-food-storage
#10
Micha Peleg, Mark D Normand, Maria G Corradini
Modern mathematical software and user-friendly interactive programs can simplify and speed up kinetics calculations. They also open the way for new approaches to storage data gathering and analysis. This is demonstrated with a recently introduced simple exponential model that is interchangeable with the Arrhenius equation and endpoints and successive points methods. This model estimates chemical degradation kinetics parameters from a small number of isothermal or nonisothermal experimental data and determines shelf life using two chemical markers, and it is a global phenomenological model for peaked reactions, such as those encountered in lipid oxidation...
January 4, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28064491/dependence-of-the-internal-structure-on-water-particle-volume-ratio-in-an-amphiphilic-janus-particle-water-oil-ternary-system-from-micelle-like-clusters-to-emulsions-of-spherical-droplets
#11
Tomohiro G Noguchi, Yasutaka Iwashita, Yasuyuki Kimura
Amphiphilic Janus particles (AJP), composed of hydrophilic and hydrophobic hemispheres, are one of the simplest anisotropic colloids, and they exhibit higher surface activities than particles with homogeneous surface properties. Consequently, a ternary system of AJP, water and oil can form extremely stable Pickering emulsions, with internal structures that depend on the Janus structure of the particles and the system composition. However, the detail of these structures has not been fully explored, especially for the composition range where the amount of the minority liquid phase and AJP are comparable, where one would expect the Janus characteristics to be directly reflected...
January 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28064067/simultaneous-determination-of-imperatorin-and-its-metabolite-xanthotoxol-in-rat-plasma-and-urine-by-lc-ms-ms-and-its-application-to-pharmacokinetic-studies
#12
Lien Ngo, Phuong Tran, Seong-Ho Ham, Jung-Hee Cho, Hea-Young Cho, Yong-Bok Lee
An accurate, precise, selective, and sensitive liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of imperatorin (IMP) and its metabolite, xanthotoxol (XAN), in rat plasma and urine samples. The analytes, along with psoralen as an internal standard, were determined by multiple reaction monitoring (MRM) operated in the positive electrospray ionization (ESI) mode. Chromatographic separation was performed on an Acquity UPLC BEH C18 column (50mm×2...
December 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28062599/in-vivo-evaluation-of-11c-preladenant-for-pet-imaging-of-adenosine-a2a-receptors-in-the-conscious-monkey
#13
Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A Dierckx, Johan de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F de Vries, Philip H Elsinga
: [(11)C]Preladenant was developed as a novel PET ligand for the adenosine A2A receptors (A2ARs). The present study aims to evaluate the suitability of [(11)C]preladenant-PET for the quantification of striatal A2ARs and the assessment of A2AR occupancy in the conscious monkey brain. METHODS: [(11)C]Preladenant was i.v. injected into conscious monkeys (n = 4, 18 PET scans) and a 91-min dynamic scan was started. Arterial blood samples in combination with metabolite analysis were obtained during the scan to provide the input function for kinetic modelling...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#14
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28058827/photocycle-of-photoactive-yellow-protein-in-cell-mimetic-environments-molecular-volume-changes-and-kinetics
#15
Cheolhee Yang, Seong Ok Kim, Yonggwan Kim, So Ri Yun, Jungkweon Choi, Hyotcherl Ihee
Using various spectroscopic techniques such as UV-visible (UV-vis) spectroscopy, circular dichroism (CD) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, small-angle X-ray scattering (SAXS), transient grating (TG), and transient absorption (TA) techniques, we investigated how cell-mimetic environments made by crowding influence the photocycle of photoactive yellow protein (PYP) in terms of the molecular volume change and kinetics. Upon addition of molecular crowding agents, the ratio of diffusion coefficients of the blue-shifted intermediate (pB) to the ground species (pG) significantly changes from 0...
January 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28048880/su-f-r-34-quantitative-perfusion-measurement-in-rectal-cancer-using-three-different-pharmacokinetic-models-implications-for-prospective-study-design
#16
K Nie, T Mao, L Shi, N Yue, S Jabbour, S Kim, X Hu, L Qian, X Sun, T Niu
PURPOSE: To compare three different pharmacokinetic models for analysis of dynamic-contrast-enhanced (DCE)-CT data with respect to different acquisition times and location of region of interest. METHODS: Eight rectal cancer patients with pre-treatment DCE-CTs were included. The dynamic sequence started 4-10seconds(s) after the injection of contrast agent. The scan included a 110s acquisition with intervals of 40×1s+15×3s+4×6s. An experienced oncologist outlined the tumor region...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048749/su-f-r-49-a-novel-kinetic-model-for-prediction-of-tumor-local-control-for-patients-with-lung-cancer
#17
H Zhong, S Siddiqui, B Zhao, H Li, K Barton, F Siddiqui, B Movsas, I Chetty
PURPOSE: Modeling tumor control probability (TCP) can help optimize treatment plans for better treatment outcomes. This study sought to quantify the radiobiological parameters of the TCP model for patients with lung cancer. METHODS: A two-compartment kinetic model was developed to model tumor regression for five NSCLC patients. The model has three parameters: cell survival fraction, dead-cell-resolving time and tumor doubling time. The last one was extended to a function of tumor volume...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048247/we-fg-202-10-assessing-hepatocellular-carcinoma-hcc-response-to-sbrt-using-dce-mri
#18
Y Yuan, M Buckstein, M Chao, K Rosenzweig, Y Lo
PURPOSE: To investigate the feasibility of using DCE-MRI to assess treatment response of HCC to SBRT. METHODS: For seven liver HCC patients treated by photon SBRT with radiation dose ranging from 35 to 50 Gy in 5 fractions, T1-weighted DCE-MRI was performed before and at 1-3 months after the treatment. Each study included one pre-contrast and five post Gd-EOB-DTPA-enhanced imaging series. The target tumor and the liver were manually outlined on the arterial phase images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047011/we-h-207a-05-spatial-co-localization-of-f-18-naf-vs-f-18-fdg-defined-disease-volumes
#19
P Ferjancic, S Harmon, S Chen, U Simoncic, R Jeraj
PURPOSE: Both [F-18]NaF and [F-18]FDG show promise for quantitative PET/CT assessment in metastatic prostate cancer to bone. Broad agreement between the tracers has been shown but voxel-wise correspondence has not been explored in depth. This study evaluates the spatial co-localization of [F-18]NaF PET and [F-18]FDG PET in bone lesions. METHODS: Seventy-three lesion contours were identified in six patients receiving dynamic NaF PET/CT and FDG PET/CT scans two hours apart using identical fields-of-view...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046320/we-fg-206-06-dual-input-tracer-kinetic-modeling-and-its-analog-implementation-for-dynamic-contrast-enhanced-dce-mri-of-malignant-mesothelioma-mpm
#20
S Lee, A Rimner, S Hayes, M Hunt, J Deasy, M Zauderer, V Rusch, N Tyagi
PURPOSE: To use dual-input tracer kinetic modeling of the lung for mapping spatial heterogeneity of various kinetic parameters in malignant MPM METHODS: Six MPM patients received DCE-MRI as part of their radiation therapy simulation scan. 5 patients had the epitheloid subtype of MPM, while one was biphasic. A 3D fast-field echo sequence with TR/TE/Flip angle of 3.62ms/1.69ms/15° was used for DCE-MRI acquisition. The scan was collected for 5 minutes with a temporal resolution of 5ߝ9 seconds depending on the spatial extent of the tumor...
June 2016: Medical Physics
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