Testic

Zinc finger protein 384 ( ZNF384 ) encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have been detected in ALL. These include E1A-binding protein P300 ( EP300 ), CREB-binding protein ( CREBBP ), transcription factor 3 ( TCF3 ), TATA-box binding protein associated factor 15 ( TAF15 ), Ewing sarcoma breakpoint region 1 gene ( EWSR1 ), AT-rich interactive domain-containing protein 1B ( ARID1B ), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 ( SMARCA4 ), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 2 ( SMARCA2 ), synergin gamma ( SYNRG ), clathrin heavy chain ( CLTC ), bone morphogenic protein 2-inducible kinase ( BMP2K ), Nipped-B-like protein ( NIPBL ), A Kinase Anchoring Protein 8 ( AKAP8 ), Chromosome 11 Open Reading Frame 74 ( C11orf74 ), DEAD-Box Helicase 42 ( DDX42 ), ATP Synthase F1 Subunit Gamma ( ATP2C1 ), Euchromatic Histone Lysine Methyltransferase 1 ( EHMT1 ), Testic Expressed 41 ( TEX41 ), etc...

INTRODUCTION: Testicular torsion is an acute pediatric surgical emergency requiring rapid diagnosis to prevent the permanent ischaemic damage of the testicles. Hydrogen Sulfide (H2S) have shown to cure tissue damage and has a role in the prevention of I/R damage. We aimed to evaluate the effect of H2S in testicular torsion. MATERIALS AND METHODS: Eighteen male, Wistar albino rats were divided into 3 groups. The sham group which is applied surgical stress. The ischemia/reperfusion group (I/R) which detorsion performed 1 h later than testicular torsion application...

Zucker (fa/fa) obese rats often have non-identical and differently sized paired testes, leaving one testis underdeveloped. Our earlier study found that the underdeveloped testes, > 30% smaller than the normal ones, have a selective decrease in docosapentaenoic acid (22:5n-6), a dominant fatty acid in the testes. This study was conducted to examine global testicular transcriptome profile in underdeveloped testes relative to developed ones using Rat Gene 2.0 ST Array (Affymetrix, USA). Testes were obtained from 14-week-old, sexually mature male obese (fa/fa) Zucker rats...

PURPOSE: There are many recent observational studies on testicular microlithiasis (TM) and risk of testicular cancer. Whether TM increases the risk of testicular cancer is still inconclusive. The objective of this updated meta-analysis was to synthesize evidence from clinical observational studies that evaluated the association between TM and testicular cancer. MATERIALS AND METHODS: We identified eligible studies by searching the PubMed, Embase and Cochrane Library before March 2014...