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https://www.readbyqxmd.com/read/29315945/inhibitory-effect-of-a-reproductive-related-serpin-on-sperm-trypsin-like-activity-implicates-its-role-in-sperm-maturation-of-penaeus-monodon
#1
Charoonroj Chotwiwatthanakun, Wanida Santimanawong, Prasert Sobhon, Somjai Wongtripop, Rapeepun Vanichviriyakit
In a number of marine animals, sperm serine proteases are important for fertilization. Penaeus monodon sperm require trypsin-like activity for a complete acrosome reaction, which exclusively occurs in sperm residing in the female thelycum. In this study, a complete cDNA sequence of reproductive tract-related Serine protease inhibitor (rrPmserpin) was identified. The longest open reading frame was composed of 1,366 nucleotides encoding 402 amino acids with a predicted pI of 6.86 and molecular mass of 44.88 kDa...
January 5, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29299903/delayed-ejaculation-pathophysiology-diagnosis-and-treatment
#2
REVIEW
Ibrahim A Abdel-Hamid, Omar I Ali
Delayed ejaculation (DE) is a poorly defined and uncommon form of male sexual dysfunction, characterized by a marked delay in ejaculation or an inability to achieve ejaculation. It is often quite concerning to patients and their partners, and sometimes frustrates couples' attempts to conceive. This article aims to review the pathophysiology of DE and anejaculation (AE), to explore our current understanding of the diagnosis, and to present the treatment options for this condition. Electronic databases were searched from 1966 to October 2017, including PubMed (MEDLINE) and Embase...
January 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29287783/effects-of-telmisartan-and-losartan-on-irradiated-testes
#3
Naira da Silva Mansano, Isabela Fernandes Jorge, Agnaldo Bruno Chies, Gustavo Arruda Viani, Maria Angélica Spadella
AIMS: To analyze the effects of radiation on the reproductive tissue of male Wistar rats and to evaluate whether treatment with the Ang II AT1 receptor antagonists telmisartan and losartan mitigate the dysfunctions resulting from this exposure. MAIN METHODS: Rats were randomly divided into groups: Control, Irradiated, Telmisartan, Losartan, Irradiated+Telmisartan, and Irradiated+Losartan. Single dose of 5Gy was administered directly into the scrotum, followed by treatment with telmisartan (12mg/kg/day) or losartan (34mg/kg/two times/day) for 60days...
December 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/29286340/slc9a3-protein-is-critical-for-acrosomal-formation-in-postmeiotic-male-germ-cells
#4
Ya-Yun Wang, Han-Sun Chiang, Chiao-Yin Cheng, Yi-No Wu, Yung-Chih Lin, Hsuan-Che Liu, Wei-Kung Tsai, Yen-Lin Chen, Ying-Hung Lin
Solute carrier family 9 isoform 3 (SLC9A3), a Na⁺/H⁺ exchanger, regulates the transepithelial absorption of Na⁺ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens. Loss of the Slc9a3 allele in mice enhances intestinal fluid and causes diarrhoea as a consequence of diminished Na⁺ and HCO₃- absorption. Hence, the loss also causes male infertility and reveals the abnormal dilated lumen of the rete testis and calcification in efferent ductules...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29241741/vasitis-nodosa-and-related-lesions-a-modern-immunohistochemical-staining-profile-with-special-emphasis-on-novel-diagnostic-dilemmas
#5
Brie E Kezlarian, Liang Cheng, Nilesh S Gupta, Sean R Williamson
Vasitis nodosa is a benign proliferation of vas deferens epithelium, thought to be a response to trauma or obstruction, usually vasectomy. Although histologic features mimic malignancy, diagnosis is usually straightforward due to the clinical context. We analyzed 21 specimens with vasitis or epididymitis nodosa with antibodies to PAX8, CD10, p63, alpha-methyl-acyl-coA-racemase (AMACR), GATA3, prostein, NKX3.1, and prostate-specific antigen (PSA). Two diagnostically problematic cases included 1) florid bladder muscle involvement after prostatectomy and 2) involvement of the ampulla and ejaculatory duct in a radical prostatectomy specimen...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29235206/sperm-storage-influences-the-potential-for-spontaneous-acrosome-reaction-of-the-sperm-in-the-newt-cynops-pyrrhogaster
#6
Shinnosuke Kon, Tae Sato, Daisuke Endo, Tomoe Takahashi, Akio Takaku, Yuni Nakauchi, Fubito Toyama, Victor B Meyer-Rochow, Eriko Takayama-Watanabe, Akihiko Watanabe
Sperm storage is supposed to influence sperm quality, although the details remain unclear. In the present study, we found that sperm stored in a sperm storage site, the vas deferens of Cynops pyrrhogaster, spontaneously undergo acrosome reaction following incubation in Steinberg's salt solution (ST). Percentages of acrosome-reacted sperm increased time-dependently to about 60% in 24 hr. The concentration of cyclic adenosine monophosphate (cAMP) was elevated after incubating sperm in ST, while dibutylyl cAMP induced an acrosome reaction...
November 20, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29232803/-successful-embolization-for-recurrent-varicocele-of-testis-after-microsurgical-subinguinal-varicocelectomy
#7
Mai Kimakura, Akira Nagahara, Shinichiro Fukuhara, Kazutoshi Fujita, Motohide Uemura, Hiroshi Kiuchi, Ryoichi Imamura, Yasushi Miyagawa, Hiroki Higashihara, Keigo Osuga, Norio Nonomura
Microscopic subinguinal varicocelectomy has a recurrence of less than 1%, and varicocele recurrence is supposed to be an uncommon post-surgery adverse event. At present, no guidelines exist for the management of recurrent varicoceles after surgery. In this report, we present two cases of post-surgery recurrent varicocele of the testis. Case_1 : A 23-year-old male patient who had undergone microscopic subinguinal varicocelectomy for a grade 3 varicocele was referred to our hospital because of recurrent varicocele...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29216686/congenital-bilateral-absence-of-the-vas-deferens-as-an-atypical-form-of-cystic-fibrosis-reproductive-implications-and-genetic-counseling
#8
REVIEW
D A S de Souza, F R Faucz, L Pereira-Ferrari, V S Sotomaior, S Raskin
Congenital bilateral absence of the vas deferens (CBAVD) is found in 1% to 2% of males with infertility and is present in 6% of obstructive azoospermia cases. Nearly 95% of men with cystic fibrosis (CF, an autosomal recessive disorder) have CBAVD. There are genetic links between CBAVD and CF. Some mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR) can lead to CBAVD as a monosymptomatic form of CF. With the use of assisted reproductive techniques (ART), especially testicular or epididymal sperm aspiration, intracytoplasmic sperm injection, and in vitro fertilization, it is possible that men with CBAVD can produce offspring...
December 7, 2017: Andrology
https://www.readbyqxmd.com/read/29197295/reproductive-aging-in-male-dogs-the-epididymal-sperm-defects-and-expression-of-androgen-receptor-in-reproductive-tissues
#9
C Bhanmeechao, S Srisuwatanasagul, N Prapaiwan, S Ponglowhapan
The present study aimed at investigating age-related changes in epididymal sperm motility, morphology, DNA integrity and androgen receptor (AR) expression in canine reproductive tissues. Fifty-five healthy medium-sized male dogs were divided into four groups: young (1 - 3 years old, n = 14), adult (>3 - 6 years old, n = 12), old (>6 - 9 years old, n = 14) and senile (>9 years old, n = 15). After routine castration, testes, epididymides (head, body and tail) and vas deferens were collected. Spermatozoa were flushed from epididymal tails and their motility, morphology and DNA integrity were examined...
November 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/29188379/inguinal-hernia-repair-by-bianchi-incision-in-boys-a-retrospective-study
#10
Junshan Lin, Dumiao Li, Jinwen Chen, Li Lin, Yali Xu
OBJECTIVE: Open inguinal hernia repair by Bianchi incision is a potential alternative technique for the treatment of IH. This study aims to retrospectively analyze boys with IH, who underwent open IH repair by Bianchi incision. METHODS: A total of 3300 boys (1-144 months) with IH from April 2007 to September 2015 were enrolled into this study. An open high scrotal incision (Bianchi incision) to ligate the processus proximal to the internal inguinal ring was performed in patients for IH repair...
November 29, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29177683/a-temporal-and-spatial-monitoring-of-organotin-pollution-in-a-harborside-region-of-brazil-by-imposex-and-ecological-quality-ratio-using-leucozonia-nassa
#11
Mercia Barcellos da Costa, Gabriela Carvalho Zamprogno, Mariana Beatriz Paz Otegui, Letícia de Morais, Felipe Corteletti Pedruzzi, Gabriel Bautz Dalbem, Daniele Angeli da Silva, Allana Cristini Borges Resende
This study represents the first use of Leucozonia nassa (Mollusca-Gastropoda) in a program of long-term monitoring. Specimens of L. nassa were collected between 2006 and 2014 and analyzed for the occurrence of imposex in two areas in Southeastern Brazil, one control area and another characterized by the presence of many ports and marinas. Imposex was evaluated in nine sites based on the percentage of females exhibiting imposex (I%), relative penis length index and vas deferens sequence index, classical indices to evaluate tributyltin (TBT) impacts...
November 25, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29160562/aqueous-extract-of-yellow-maca-lepidium-meyenii-improves-sperm-count-in-experimental-animals-but-response-depends-on-hypocotyl-size-ph-and-routes-of-administration
#12
L Sanchez-Salazar, G F Gonzales
Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29111388/activin-over-expression-in-the-testis-of-mice-lacking-the-inhibin-%C3%AE-subunit-gene-is-associated-with-androgen-deficiency-and-regression-of-the-male-reproductive-tract
#13
Rukmali Wijayarathna, David M de Kretser, Andreas Meinhardt, Ralf Middendorff, Helen Ludlow, Nigel P Groome, Kate A Loveland, Mark P Hedger
Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha(-/-)). Serum and intratesticular activin B, although not activin A and follistatin, were increased in Inha(-/-) mice at 25 days of age, but all three proteins were elevated at 56 days. None of these proteins were altered within the epididymis and vas deferens at either age. At 25 days, histology of the epididymis and vas deferens was similar to wild-type...
October 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29091118/imposex-in-stramonita-haemastoma-from-coastal-sites-of-cartagena-colombia
#14
L Sierra-Marquez, J Sierra-Marquez, J De la Rosa, J Olivero-Verbel
Imposex is the development of male sexual characteristics caused by the toxic effects of some chemicals that acts as an endocrinal disruptor. Antifouling paints contain these chemicals. Cartagena lacks studies to indicate the extent of imposex in its coastal waters. The aim of this study was to determine the prevalence of imposex in the gastropod Stramonita haemastoma in Cartagena, Colombia. Specimens were collected during 2013 from locations of high and low influence of port activity. Morphometric measurements and the frequency of the occurrence of imposex were registered...
October 30, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29090093/effects-of-pituitary-specific-overexpression-of-fsh%C3%AE-%C3%AE-on-reproductive-traits-in-transgenic-boars
#15
Wenting Li, Yujun Quan, Mengmeng Zhang, Kejun Wang, Muzhen Zhu, Ye Chen, Qiuyan Li, Keliang Wu
BACKGROUND: Follicle-stimulating hormone (FSH) is a gonadotropin synthesized and secreted by the pituitary gland. FSH stimulates follicle development and maturation in females. It also plays an important role in spermatogenesis in males, including humans and mice. However, the effects of FSH on male pigs are largely unknown. In this study, we generated transgenic pigs to investigate the effects of FSHα/β overexpression on reproductive traits in boars. RESULTS: After five transgenic F0 founders were crossed with wide-type pigs, 193 F1 animals were obtained...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29066868/protective-effect-of-da-9401-in-finasteride-induced-apoptosis-in-rat-testis-inositol-requiring-kinase-1-and-c-jun-n-terminal-kinase-pathway
#16
Kiran Kumar Soni, Yu Seob Shin, Bo Ram Choi, Keshab Kumar Karna, Hye Kyung Kim, Sung Won Lee, Chul Young Kim, Jong Kwan Park
Finasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD) rats. Forty adult male SD rats were assigned to four groups: control (CTR), finasteride 1 mg/kg/day (F), finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100) and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200). Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT) and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen's score and apoptosis...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29064653/prostate-cancer-recurrence-in-vas-deferens-fusion-image-guide-as-an-important-tool-in-dignosis
#17
Leonardo Guedes Moreira Valle, Antônio Rahal, Priscila Mina Falsarella, Juliano Ribeiro de Andrade, Oren Smaletz, Akemi Osawa, Rodrigo Gobbo Garcia
The biochemical recurrence after local treatment for prostate cancer is an often challenging condition of clinical management. The aim of this report is to demonstrate the importance of the association of various imaging methods in the identification and subsequent accurate percutaneous biopsy in patients with recurrence of prostate cancer, especially in unusual sites. An 86 years old male with biochemical recurrence, during radiological investigation a PET-MRI was noted the presence of an asymmetry of the vas deferens with PSMA- 68Ga uptaken, suggesting the recurrence...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29057334/antouka-super-%C3%A2-induced-oxidative-stress-and-reproductive-toxicity-in-male-japanese-quail-coturnix-coturnix-japonica
#18
Ngoula Ferdinand, Ngoumtsop Victor Herman, Ngouateu Kenfack Omer Bebe, Kenfack Augustave, Mutwedu Valence, Nguemmogne Tamdem Ghislaine, Tchoffo Herve, Azafack Kana Dorice, Deutcheu Sorelle, Manjeli Yacouba
BACKGROUND: Antouka Super(®) (AS), a combination of insecticide (Pirimiphos-methyl 16% and Permethrin 3%), is one of the most widely used pesticides in agriculture, public health, home and garden, with high potential for human and animal exposure. OBJECTIVE: The present study was undertaken to evaluate the effect of AS on the serum testosterone, oxidative stress biomarkers, testis histology and fertility of male Japanese quail. METHODS: Thirty-two (32) male Japanese quails twenty-eight (28) days were randomly divided into four groups: C0 (control), T1, T2 and T3, exposed daily (gavage) to 0, 37...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29056578/treatment-for-vas-deferens-obstruction-following-childhood-herniorrhaphy
#19
Jin Wang, Qian Liu, Youpeng Zhang, Yongbiao Cheng, Sen Li, Hanqing Zeng, Zhaohui Zhu
OBJECTIVES: To enhance the management of inguinal obstruction, and to present the procedures and results of our surgical strategy for vas deferens obstruction following childhood herniorrhaphy. METHODS: We treated a total of 56 patients diagnosed with obstructive azoospermia following bilateral inguinal herniorrhaphy. First, conventional inguinal open surgery was performed. If the abdominal vas was not identified in the inguinal region, laparoscopy was used to retrieve the deeper abdominal vas deferens, which was obstructed above the internal inguinal ring...
October 19, 2017: Urology
https://www.readbyqxmd.com/read/29038035/biochemical-and-pharmacological-characterization-of-three-opioid-nociceptin-hybrid-peptide-ligands-reveals-substantially-differing-modes-of-their-actions
#20
Anna I Erdei, Adina Borbély, Anna Magyar, Nóra Taricska, András Perczel, Ottó Zsíros, Győző Garab, Edina Szűcs, Ferenc Ötvös, Ferenc Zádor, Mihály Balogh, Mahmoud Al-Khrasani, Sándor Benyhe
In an attempt to design opioid-nociceptin hybrid peptides, three novel bivalent ligands, H-YGGFGGGRYYRIK-NH2, H-YGGFRYYRIK-NH2 and Ac-RYYRIKGGGYGGFL-OH were synthesized and studied by biochemical, pharmacological, biophysical and molecular modelling tools. These chimeric molecules consist of YGGF sequence, a crucial motif in the N-terminus of natural opioid peptides, and Ac-RYYRIK-NH2, which was isolated from a combinatorial peptide library as an antagonist or partial agonist that inhibits the biological activity of the endogenously occurring heptadecapeptide nociceptin...
October 13, 2017: Peptides
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