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Nikolaos Dagres, Tze-Fan Chao, Guilherme Fenelon, Luis Aguinaga, Daniel Benhayon, Emelia J Benjamin, T Jared Bunch, Lin Yee Chen, Shih-Ann Chen, Francisco Darrieux, Angelo de Paola, Laurent Fauchier, Andreas Goette, Jonathan Kalman, Lalit Kalra, Young-Hoon Kim, Deirdre A Lane, Gregory Y H Lip, Steven A Lubitz, Manlio F Márquez, Tatjana Potpara, Domingo Luis Pozzer, Jeremy N Ruskin, Irina Savelieva, Wee Siong Teo, Hung-Fat Tse, Atul Verma, Shu Zhang, Mina K Chung
No abstract text is available yet for this article.
March 18, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Ramy K A Sayed, Marisol Fernández-Ortiz, María E Diaz-Casado, Iryna Rusanova, Ibtissem Rahim, Germaine Escames, Luis C López, Doaa M Mokhtar, Darío Acuña-Castroviejo
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 months of age, with reduction of muscle fibers' number, muscle weight/body weight ratio, lactate, and locomotor activity...
March 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Bruno Leite Rodrigues, Luís Fernando Carvalho-Costa, Israel de Souza Pinto, José Manuel Macário Rebêlo
Sand fly (Diptera: Psychodidae) taxonomy is complex and time-consuming, which hampers epidemiological efforts directed toward controlling leishmaniasis in endemic regions such as northeastern Brazil. Here, we used a fragment of the mitochondrial cytochrome c oxidase I (COI) gene to identify sand fly species in Maranhão State (northeastern Brazil) and to assess cryptic diversity occurring at different spatial scales. For this, we obtained 148 COI sequences of 15 sand fly species (10 genera) from Maranhão (fine spatial scale), and joined them to COI sequences from other Brazilian localities (distant about 2,000 km from Maranhão, broad spatial scale) available in GenBank...
March 17, 2018: Journal of Medical Entomology
Jingjing Song, Da Ma, Xiangqi Liu, Yichen Chen, Juan Fang, Vivian Wai Yan Lui, Sijia Zhao, Juan Xia, Bin Cheng, Zhi Wang
Thrombomodulin (TM, also known as CD141), which functions as an anticoagulant, is widely expressed on cell surface of a variety of cell types, including human blood cells as well as certain immune cells. To determine whether TM could be a potential marker for OSCC diagnosis as well as a molecular target for OSCC therapy, we examined the expression of TM in an oral cancer tissue microarray with 153 oral cancer tissues. Further, we also analyzed the expression of TM on DCs of 36 OSCC patients and 36 healthy donors...
March 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Jesús Mosquera Mosquera, Malou Henriksen-Lacey, Isabel García, Miguel Martínez-Calvo, Jessica Rodriguez Villar, José L Mascareñas, Luis M Liz-Marzán
We describe an approach to regulate the cellular uptake of small gold nanoparticles using supramolecular chemistry. The strategy relies on the functionalization of AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular uptake can be activated in situ through the addition of cationic covalent cages that specifically recognize the fluorescent pyranine dyes and counterbalance the negative charges. The high selectivity and reversibility of the host-guest recognition activates cellular uptake, even in protein-rich biological media, as well as its regulation by rational addition of either cage or pyranine...
March 21, 2018: Journal of the American Chemical Society
Illce B Lázaro-Pacheco, Alfredo I Servín-Caamaño, José L Pérez-Hernández, Gabriela Rojas-Loureiro, Luis Servín-Abad, Fátima Higuera-DE LA Tijera
BACKGROUND: Acid suppression has been associated with adverse events; such as, enteric infections. Proton pump inhibitors (PPI) are frequently prescribed in patients with cirrhosis, but is unclear if PPI are associated with the development of bacterial infections in these patients. OBJECTIVE: To assess the impact of PPI intake on the development of bacterial, viral and fungal infections in patients with cirrhosis. METHODS: An observational, retrospective, historic cohort study...
January 2018: Arquivos de Gastroenterologia
Maria Ángeles Pérez-Albacete Martínez, Carlos Pérez-Albacete Martínez, José Eduardo Maté Sánchez De Val, María Luisa Ramos Oltra, Manuel Fernández Domínguez, Jose Luis Calvo Guirado
The aim of this study was to evaluate osseointegration and crestal bone height in implants with a triangular cervical design in comparison with a standard rounded cervical design. The control group consisted of 24 implants with a standard cervical design, and the test group of 24 implants with a triangular cervical design. The implants were inserted in healed bone in six American Foxhounds. Crestal bone height and tissue thickness in the cervical portion were measured after 12 weeks healing. Data analysis found mean crestal bone loss of: 0...
March 21, 2018: Materials
Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Alp Can, Adriana Di Polo, Turgay Dalkara
Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, most notably α-smooth muscle actin (α-SMA), has questioned these findings. Using strategies that allow rapid filamentous-actin (F-actin) fixation (i.e. snap freeze fixation with methanol at -20°C) or prevent F-actin depolymerization (i.e. with F-actin stabilizing agents), we demonstrate that pericytes on mouse retinal capillaries, including those in intermediate and deeper plexus, express α-SMA...
March 21, 2018: ELife
Juliana M Schöntag, Alcione A Alves, Luis G Romero Esquivel, Maurício L Sens
Population growth requires more food production and as a consequence, there is the indiscriminate use of agrochemicals, among them major group are carbamates. At times, runoff of pesticides leads to surface water pollution that serves as a source of public supply. Thus, the presence of these microcontaminants in surface water has become increasingly frequent. The treatment developed in this work uses the principle of adsorption as a technology for the removal of carbamates, more specifically carbofuran. Two methods of coating the polystyrene beads with iron oxide were used to adsorb these microcontaminants from the water...
March 21, 2018: Environmental Technology
Maria Jose Escalante, Jose Maria Ceriani-Cernadas, Ivonne D'Apremont, Aldo Bancalari, Veronica Webb, Larisa Genes, Luis Villarroel, Elizabeth Munoz, Jose L Tapia
OBJECTIVE: The main aim is to determine the incidence and associated factors of late onset sepsis (LOS) in very low birth weight (VLBW) infants (500-1500 g), from the NEOCOSUR Network during years 2001-2013. Secondary objectives are to describe the microbiology of the first and second episode of LOS and to study the association between catheter dwell time and LOS. PATIENTS AND METHODS: Demographic information and outcome data are prospectively and routinely collected across the Network using predefined diagnostic criteria and online data entry...
March 14, 2018: Pediatric Infectious Disease Journal
Joseph Ting, Ashley Roberts, Anne Synnes, Roderick Canning, Jaya Bodani, Luis Monterossa, Prakesh S Shah
BACKGROUND: Neonatal fungaemia is associated with adverse neonatal outcomes and higher overall healthcare expenditure. Our objective is to review the epidemiology of invasive fungal infections (IFIs) in neonates in Canada. METHODS: A retrospective cohort study using data collected by the Canadian Neonatal Network (CNN) was conducted. Using a nested matched cohort study design, risk factors and outcomes of neonates born <33 weeks gestation (n=39,305) during 2003-2013 were compared between neonates diagnosed with an IFI during their stay to infection-free controls...
March 15, 2018: Pediatric Infectious Disease Journal
Manuel Montoza-Aguado, Carlos Salgado-García, Luis Falcón-Márquez, Ana Luna-Alcaide, Amelia Jiménez-Heffernan, Carmen Puentes-Zarzuela
One of the alternative methods for the measurement of radiochemical purity (RCP) of Technetium-sestamibi uses Whatman 3MM paper as the stationary phase and ethyl acetate as the mobile phase. However, alternative method shows peak splitting and shouldering of the radiopharmaceutical. This could be because of higher levels of analyte. We aimed to assess the effect of sample dilution (1 : 1) on this method and to compare these RCP values with the reference method. The diluted samples showed a unique peak in the radiopharmaceutical zone, but the RCP values were significantly different (P<0...
March 20, 2018: Nuclear Medicine Communications
Leticia Leon, Luis Rodriguez-Rodriguez, Maria Dolores Aguilar, Juan Ángel Jover, Cristina Vadillo, Marta Redondo, Lydia Abasolo
OBJECTIVE: The aim of this study was to assess the reliability and validity of the Spanish version of the Rosser classification system for disease states in patients with musculoskeletal disorders. METHODS: Our study was based on a questionnaire validation design. Patients were attended at an outpatient rheumatology clinic at Hospital Clínico San Carlos, Madrid, Spain. The Rosser classification system was completed by the physician from the research team (PMQ) and by the patient (HMQ)...
March 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Sarah Theiner, Márkó Grabarics, Luis Galvez, Hristo P Varbanov, Nadine S Sommerfeld, Markus Galanski, Bernhard K Keppler, Gunda Koellensperger
The potential advantage of platinum(iv) complexes as alternatives to classical platinum(ii)-based drugs relies on their kinetic stability in the body before reaching the tumor site and on their activation by reduction inside cancer cells. In this study, an analytical workflow has been developed to investigate the reductive biotransformation and kinetic inertness of platinum(iv) prodrugs comprising different ligand coordination spheres (respectively, lipophilicity and redox behavior) in whole human blood. The distribution of platinum(iv) complexes in blood pellets and plasma was determined by inductively coupled plasma-mass spectrometry (ICP-MS) after microwave digestion...
March 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
J Luis Espinoza
No abstract text is available yet for this article.
March 20, 2018: Journal of Internal Medicine
Luis Varona, Andres Legarra, Miguel A Toro, Zulma G Vitezica
In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i) they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii) they allow the definition of mate allocation procedures between candidates for selection; and (iii) they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes...
2018: Frontiers in Genetics
Rebeca Martín, Luis G Bermúdez-Humarán, Philippe Langella
Faecalibacterium prausnitzii represents approximately 5% of the total fecal microbiota in healthy adults being one of the most abundant bacterium in the human intestinal microbiota of healthy adults. Furthermore, this bacterium has been proposed to be a sensor and a major actor of the human intestinal health because of its importance in the gut ecosystem. In this context, F. prausnitzii population levels have been found to be reduced in patients suffering from several syndromes and diseases such as inflammatory bowel diseases...
2018: Frontiers in Microbiology
Rosa M Agra, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Alberto Cordero, Alfonso Varela-Román, Inés Gómez-Otero, J Nicolás López- Canoa, Ángel Luis Fernández, José Manuel Martínez-Cereijo, José Ramón González-Juanatey, Sonia Eiras
Background: Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear. Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF. Methods: Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for de novo HF (n=74). Nutritional status was determined by CONUT score. Univariate and multivariate Cox regression analyses were employed to calculate the estimated hazard ratio (HR) with 95% confidence interval (CI) for death or all-cause readmission...
2018: International Journal of Medical Sciences
Michael E Hall, Jennifer H Jordan, Luis A Juncos, W Gregory Hundley, John E Hall
Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important...
2018: International Journal of Nephrology and Renovascular Disease
Daniella Braz Parente, Jaime Araújo Oliveira Neto, Antonio Luis Eiras de Araújo, Rosana Souza Rodrigues, Renata Mello Perez, Edson Marchiori
The aim of this pictorial essay is to review the spectrum of fat-containing liver lesions and their characterisation on magnetic resonance imaging with focus on the radiological features that aid in the differential diagnoses. Fat-containing liver lesions comprise a heterogeneous group of tumours with variable imaging findings. Magnetic resonance imaging clearly displays the micro- and macroscopic fat components of the lesions and other characteristic features that are helpful tools to make the differential diagnosis...
January 2018: Radiologia Brasileira
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