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https://www.readbyqxmd.com/read/28343277/pancreatic-alpha-cell-selective-deletion-of-tcf7l2-impairs-glucagon-secretion-and-counter-regulatory-responses-to-hypoglycaemia-in-mice
#1
Gabriela da Silva Xavier, Angeles Mondragon, Vishnou Mourougavelou, Céline Cruciani-Guglielmacci, Jessica Denom, Pedro Luis Herrera, Christophe Magnan, Guy A Rutter
AIMS/HYPOTHESIS: Transcription factor 7-like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wnt signalling pathway. SNPs in the TCF7L2 gene have previously been associated with an increased risk of type 2 diabetes in genome-wide association studies. In animal studies, loss of Tcf7l2 function is associated with defective islet beta cell function and survival. Here, we explore the role of TCF7L2 in the control of the counter-regulatory response to hypoglycaemia by generating mice with selective deletion of the Tcf7l2 gene in pancreatic alpha cells...
March 25, 2017: Diabetologia
https://www.readbyqxmd.com/read/28343016/evaluation-of-antitumor-activity-and-cardiac-toxicity-of-a-bone-targeted-ph-sensitive-liposomal-formulation-in-a-bone-metastasis-tumor-model-in-mice
#2
Diego Dos Santos Ferreira, Bruno Luís Jesus de Oliveira Pinto, Vidhya Kumar, Valbert Nascimento Cardoso, Simone Odília Fernandes, Cristina Maria Souza, Geovanni Dantas Cassali, Anna Moore, David Sosnovik, Christian Farrar, Elaine Amaral Leite, Ricardo José Alves, Mônica Cristina de Oliveira, Alexander Ramos Guimarães, Peter Caravan
Chemotherapy for bone tumors is a major challenge because of the inability of therapeutics to penetrate dense bone mineral. We hypothesize that a nanostructured formulation with high affinity for bone could deliver drug to the tumor while minimizing off-target toxicity. Here, we evaluated the efficacy and toxicity of a novel bone-targeted, pH-sensitive liposomal formulation containing doxorubicin in an animal model of bone metastasis. Biodistribution studies with the liposome showed good uptake in tumor, but low accumulation of doxorubicin in the heart...
March 22, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28342996/induction-of-neuroendocrine-differentiation-in-prostate-cancer-cells-by-dovitinib-tki-258-and-its-therapeutic-implications
#3
Shalini S Yadav, Jinyi Li, Jennifer A Stockert, Bryan Herzog, James O'Connor, Luis Garzon-Manco, Ramon Parsons, Ashutosh K Tewari, Kamlesh K Yadav
Prostate cancer (PCa) remains the second-leading cause of cancer-related deaths in American men with an estimated mortality of more than 26,000 in 2016 alone. Aggressive and metastatic tumors are treated with androgen deprivation therapies (ADT); however, the tumors acquire resistance and develop into lethal castration resistant prostate cancer (CRPC). With the advent of better therapeutics, the incidences of a more aggressive neuroendocrine prostate cancer (NEPC) variant continue to emerge. Although de novo occurrences of NEPC are rare, more than 25% of the therapy-resistant patients on highly potent new-generation anti-androgen therapies end up with NEPC...
March 23, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28342737/are-lower-urinary-tract-symptoms-in-children-associated-with-urinary-symptoms-in-their-mothers
#4
Ariane S Sampaio, Luis Gustavo A Fraga, Bruno A Salomão, Júlia B Oliveira, Camila L Seixas, Maria Luiza Veiga, José Murillo B Netto, Ubirajara Barroso
BACKGROUND: The association between parents who suffered daytime incontinence as children and children who are incontinence has been reported. However, the association of lower urinary tract (LUT) dysfunction in children and urinary symptoms in mothers has not been studied. OBJECTIVE: To test the hypothesis that the children of mothers with lower urinary tract symptoms (LUTS) are more likely to have urinary symptoms. STUDY DESIGN: A cross-sectional multicenter study was conducted in two cities in Brazil...
February 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28342715/prediction-of-neonatal-respiratory-morbidity-by-quantitative-ultrasound-lung-texture-analysis-a-multicenter-study
#5
Montse Palacio, Elisenda Bonet-Carne, Teresa Cobo, Alvaro Perez-Moreno, Joan Sabrià, Jute Richter, Marian Kacerovsky, Bo Jacobsson, Raúl A García-Posada, Fernando Bugatto, Ramon Santisteve, Àngels Vives, Mauro Parra-Cordero, Edgar Hernandez-Andrade, José Luis Bartha, Pilar Carretero-Lucena, Kai Lit Tan, Rogelio Cruz-Martínez, Minke Burke, Suseela Vavilala, Igor Iruretagoyena, Juan Luis Delgado, Mauro Schenone, Josep Vilanova, Francesc Botet, George Sh Yeo, Jon Hyett, Jan Deprest, Roberto Romero, Eduard Gratacos
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure, limit the use of fetal lung maturity assessment. OBJECTIVE: To evaluate the performance of quantitative ultrasound texture analysis (quantusFLM®) to predict neonatal respiratory morbidity in preterm and early-term (<39.0 weeks) deliveries ...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28342438/-use-of-the-term-%C3%A2-pre-embryo%C3%A2-in-the-biomedical-literature-from-its-origin-to-the-present
#6
Modesto Ferrer Colomer, Luis Miguel Pastor
In this article, we present a review about the use of the term ″preembryo″ in the scientific literature as well as Bioethics from its origin, back in June 1979, to the end of the year 2014. We analyze their evolution along the time comparing with other terms commonly used in embryology. Also, we show the relevant journals in which this term appears, (offering the impact index within their specific field), and the authors who use it the most. The term ″preembryo″ arose in the scientific literature in 1979, remaining for about 6 years without reappearing in the scientific literature...
January 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28342431/-considerations-for-the-definition-of-a-interval-of-vulnerability-possibility-in-adolescence
#7
José Víctor Orón Semper, Luis Enrique Echarte Alonso
This article explores the hypothesis that while maturation related cognitive abilities reaches maturity around the age of fifteen, maturation related social skills is delayed until well into the twenties. Our goal is to try to define what is the window of opportunity/vulnerability and what is the maturational status of the young in this interval. In this context, we argue how the maturational time of the closing of adolescence has an impact on the valuation of autonomy in decision-making of the person. Particularly, we figure out implications for the assessment of the autonomy of youth in health issues, and also criminal liability...
January 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28341344/propofol-affinity-to-mitochondrial-membranes-does-not-alter-mitochondrial-function
#8
Luís M Félix, Fernando Correia, Pedro A Pinto, Sónia P Campos, Telma Fernandes, Romeu Videira, M Manuel Oliveira, Francisco P Peixoto, Luís M Antunes
The molecular mechanisms of hepatotoxicity after propofol anaesthesia have not been fully elucidated, although there is a relation with mitochondrial dysfunction. The action of propofol on mitochondrial hepatic functions in a rat model was evaluated by infusion for 4h with 25 and 62.5mg/kg/h propofol or 3.125ml/kg/h (vehicle). Liver mitochondrial respiratory rates were evaluated as well as mitochondrial transmembrane potential (ΔΨ), calcium fluxes, mitochondrial enzymatic activities (Complex I - V) and oxidative stress biomarkers (superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase, lipid peroxidation and the oxidized/reduced glutathione ratio)...
March 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28340322/immunogenicity-and-safety-of-primary-and-booster-vaccination-with-2-investigational-formulations-of-diphtheria-tetanus-and-haemophilus-influenzae-type-b-antigens-in-a-hexavalent-dtpa-hbv-ipv-hib-combination-vaccine-in-comparison-with-the-licensed-infanrix-hexa
#9
Timo Vesikari, Luis Rivera, Tiina Korhonen, Anitta Ahonen, Brigitte Cheuvart, Marjan Hezareh, Winnie Janssens, Narcisa Mesaros
Safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and Haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Hib vaccine (DTPa-HBV-IPV/Hib) were evaluated in a Primary (NCT01248884) and a Booster vaccination (NCT01453998) study. In the Primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of DTPa-HBV-IPV/Hib formulation A (DATAPa-HBV-IPV/Hib), or B (DBTBPa-HBV-IPV/Hib) or the licensed DTPa-HBV-IPV/Hib vaccine (Infanrix hexa, GSK; control group) at 2, 3, 4 months of age...
March 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28340281/high-ten-year-remission-rates-following-rituximab-fludarabine-mitoxantrone-and-dexamethasone-r-fnd-with-interferon-maintenance-in-indolent-lymphoma-results-of-a-randomized-study
#10
Loretta J Nastoupil, Peter McLaughlin, Lei Feng, Sattva S Neelapu, Felipe Samaniego, Fredrick B Hagemeister, Ana Ayala, Jorge E Romaguera, Andre H Goy, Eleanor Neal, Michael Wang, Luis Fayad, Michelle A Fanale, Yasuhiro Oki, Jason R Westin, Maria A Rodriguez, Fernando Cabanillas, Nathan H Fowler
We report a single-centre, randomized study evaluating the efficacy and safety of concurrent fludarabine, mitoxantrone, dexamethasone (FND) and rituximab versus sequential FND followed by rituximab in 158 patients with advanced stage, previously untreated indolent lymphoma, enrolled between 1997 and 2002. Patients were randomized to 6-8 cycles of FND followed by 6 monthly doses of rituximab or 6 doses of rituximab given concurrently with FND. All patients who achieved at least a partial response received 12 months of interferon (IFN) maintenance...
March 24, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28340239/hypertension-in-dialysis-patients-a-consensus-document-by-the-european-renal-and-cardiovascular-medicine-eureca-m-working-group-of-the-european-renal-association-european-dialysis-and-transplant-association-era-edta-and-the-hypertension-and-the-kidney-working
#11
Pantelis A Sarafidis, Alexandre Persu, Rajiv Agarwal, Michel Burnier, Peter de Leeuw, Charles J Ferro, Jean-Michel Halimi, Gunnar H Heine, Michel Jadoul, Faical Jarraya, Mehmet Kanbay, Francesca Mallamaci, Patrick B Mark, Alberto Ortiz, Gianfranco Parati, Roberto Pontremoli, Patrick Rossignol, Luis Ruilope, Patricia Van der Niepen, Raymond Vanholder, Marianne C Verhaar, Andrzej Wiecek, Gregoire Wuerzner, Gérard M London, Carmine Zoccali
In patients with end-stage renal disease (ESRD) treated with haemodialysis or peritoneal dialysis, hypertension is common and often poorly controlled. Blood pressure (BP) recordings obtained before or after haemodialysis display a J- or U-shaped association with cardiovascular events and survival, but this most likely reflects the low accuracy of these measurements and the peculiar haemodynamic setting related to dialysis treatment. Elevated BP detected by home or ambulatory BP monitoring is clearly associated with shorter survival...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28340180/reliability-study-in-five-languages-of-the-translation-of-the-pain-observational-scale-algoplus
#12
Gisèle Pickering, Fiammetta Monacelli, Juan Manuel Pérez-Castejón Garrote, Hirondina Guarda, Luis Batalha, Stephen Gibson, Sumru Savas, Patrizio Odetti, Federica Gandolfo, Elisa Pastorino, Maria José Carrilho Mugeiro, Isabel Pereira Dias, Asli Kilavuz, Nicolas Macian, Bruno Pereira
Objective. : Acute pain is frequent and underestimated in older persons, especially when they suffer from cognitive impairment. Algoplus is an observational scale for acute pain evaluation, validated in French in older persons with communication disorders. We present the validation by an international expert team of the Algoplus scale in five languages: English, Spanish, Italian, Portuguese, and Turkish. Methods. : A total of 181 older consecutive patients were included in five countries (Spain, Australia, Italy, Portugal, and Turkey)...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340167/factors-influencing-cognitive-impairment-in-neuropathic-and-musculoskeletal-pain-and-fibromyalgia
#13
Begoña Ojeda, María Dueñas, Alejandro Salazar, Juan Antonio Mico, Luis Miguel Torres, Inmaculada Failde
Objective.:  To assess cognitive performance of chronic pain (CP) patients diagnosed with three types of pain-neuropathic pain (NP), musculoskeletal (MSK), and fibromyalgia (FM)-and to analyze the factors influencing cognitive difficulties in each group. Methods.:  Two hundred fifty-four CP patients-104 NP, 99 MSK, 51 FM-and 72 pain-free subjects were included in the study. The "Test Your Memory" (TYM) scale was used to assess cognitive performance. Pain intensity was measured by means of the visual analog scale (VAS); the Hospital Anxiety and Depression scale was used to assess mental status, and the Medical Outcome Study (MOS) sleep scale to assess sleep quality...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339963/anti-apoptotic-effects-of-decyl-gallate-on-the-induction-of-apoptosis-in-a549-pneumocytes-by-paracoccidioides-brasiliensis-gp43
#14
Thais Bernardi, Julhiany de Fátima da Silva, Juliana Vicentin, Haroldo Cesar de Oliveira, Patricia Akemi Assato, Caroline Maria Marcos, Ana Carolina Alves de Paula E Silva, Rosangela Aparecida Moraes da Silva, Luis Octávio Regasini, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Apoptosis is considered an escape mechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties...
March 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28339945/single-site-ventricular-pacing-via-the-coronary-sinus-in-patients-with-tricuspid-valve-disease
#15
Amit Noheria, Martin van Zyl, Luis R Scott, Komandoor Srivathsan, Malini Madhavan, Samuel J Asirvatham, Christopher J McLeod
Aims: To evaluate coronary sinus single-site (CSSS) left ventricular pacing in adult patients with normal left ventricular ejection fraction (LVEF) when traditional right ventricular lead implantation is not feasible or is contraindicated. Methods and results: We performed a retrospective analysis of 23 patients with tricuspid valve surgery/disease who received a CSSS ventricular pacing lead to avoid crossing the tricuspid valve. Two matched control populations were obtained from patients receiving (i) conventional right ventricular single-site (RVSS) leads and (ii) coronary sinus leads for cardiac resynchronization therapy (CSCRT)...
March 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339914/infant-colonization-with-methicillin-resistant-staphylococcus-aureus-or-vancomycin-resistant-enterococci-preceding-neonatal-intensive-care-unit-discharge
#16
Sarah A Clock, Haomiao Jia, Sameer Patel, Yu-Hui Ferng, Luis Alba, Susan Whittier, Patricia DeLaMora, Setareh Tabibi, Jeffrey Perlman, David Paul, Theoklis Zaoutis, Elaine Larson, Lisa Saiman
Rates of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and/or vancomycin-resistant enterococci (VRE) were determined for 1320 infants within 7 days of neonatal intensive care unit discharge. Overall, 4% and 1% of the infants were colonized with MRSA or VRE, respectively. Predictors identified in fixed-effects models were surgery during hospitalization (for MRSA colonization) and prolonged antimicrobial treatment (for VRE colonization).
March 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339660/eculizumab-in-secondary-atypical-haemolytic-uraemic-syndrome
#17
Teresa Cavero, Cristina Rabasco, Antía López, Elena Román, Ana Ávila, Ángel Sevillano, Ana Huerta, Jorge Rojas-Rivera, Carolina Fuentes, Miquel Blasco, Ana Jarque, Alba García, Santiago Mendizabal, Eva Gavela, Manuel Macía, Luis F Quintana, Ana María Romera, Josefa Borrego, Emi Arjona, Mario Espinosa, José Portolés, Carolina Gracia-Iguacel, Emilio González-Parra, Pedro Aljama, Enrique Morales, Mercedes Cao, Santiago Rodríguez de Córdoba, Manuel Praga
Background.: Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods.: We identified 29 patients with so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 × 10 9 /L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a ≥25% reduction of serum creatinine from the onset of eculizumab administration...
February 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339473/characterization-of-lignocellulolytic-activities-from-fungi-isolated-from-the-deep-sea-sponge-stelletta-normani
#18
Ramón Alberto Batista-García, Thomas Sutton, Stephen A Jackson, Omar Eduardo Tovar-Herrera, Edgar Balcázar-López, María Del Rayo Sánchez-Carbente, Ayixon Sánchez-Reyes, Alan D W Dobson, Jorge Luis Folch-Mallol
Extreme habitats have usually been regarded as a source of microorganisms that possess robust proteins that help enable them to survive in such harsh conditions. The deep sea can be considered an extreme habitat due to low temperatures (<5°C) and high pressure, however marine sponges survive in these habitats. While bacteria derived from deep-sea marine sponges have been studied, much less information is available on fungal biodiversity associated with these sponges. Following screening of fourteen fungi isolated from the deep-sea sponge Stelletta normani sampled at a depth of 751 metres, three halotolerant strains (TS2, TS11 and TS12) were identified which displayed high CMCase and xylanase activities...
2017: PloS One
https://www.readbyqxmd.com/read/28339363/proangiogenic-gene-polymorphisms-are-associated-with-susceptibility-to-paget-s-disease-of-bone-and-with-its-clinical-features
#19
Ismael Calero-Paniagua, Ricardo Usategui-Martín, Luís Corral-Gudino, Judit García-Aparicio, Javier Del Pino-Montes, Rogelio González-Sarmiento
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March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339127/quantitative-ultrasound-texture-analysis-for-differentiating-preterm-from-term-fetal-lungs
#20
Sleiman R Ghorayeb, Luis A Bracero, Matthew J Blitz, Zara Rahman, Martin L Lesser
OBJECTIVES: To differentiate preterm (<37 weeks' gestation) from term (≥37 weeks' gestation) fetal lungs by using quantitative texture analysis of ultrasound images. METHODS: This study retrospectively evaluated singleton gestations with valid dating at 20 weeks' gestational age (GA) or later between January 2015 and December 2015. Images were obtained from Voluson E8 ultrasound systems (GE Healthcare, Milwaukee, WI). A region of interest was selected in each fetal lung image at the level of the 4 heart chambers from an area that appeared most representative of the overall lung tissue and had the least shadow...
March 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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