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https://www.readbyqxmd.com/read/28214292/prescription-profile-of-pyridostigmine-use-in-a-population-of-patients-with-myasthenia-gravis
#1
Jorge Enrique Machado-Alba, Luis Felipe Calvo-Torres, Andrés Gaviria-Mendoza, César Augusto Mejía-Vélez
INTRODUCTION: We determined the pyridostigmine prescription pattern in a population of patients with myasthenia gravis. METHODS: A descriptive cross-sectional study was done using a prescription database of 3.5 million individuals from which patients diagnosed with myasthenia gravis (MG) and for whom pyridostigmine was prescribed. RESULTS: A total of 306 outpatients with MG were found, and 258 were receiving pyridostigmine, mean age, 53.0±18...
February 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28214112/communicating-airport-noise-emission-data-to-the-general-public
#2
REVIEW
Luis Gasco, Cesar Asensio, Guillermo de Arcas
Despite the efforts that the aviation industry has undertaken during the last few decades, noise annoyance remains high, partly because of the continuous transport demands of modern societies and partly because of changes in citizen expectations and their growing environmental concerns. Although modern aircraft are considerably quieter than their predecessors, the number of complaints has not decreased as much as expected. Therefore, the aeronautical sector has tried more sociological and/or psychological strategies to gain acceptance through awareness and community engagement...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213999/application-of-the-acoustic-voice-quality-index-for-objective-measurement-of-dysphonia-severity
#3
Faustino Núñez-Batalla, Estefanía Díaz-Fresno, Andrea Álvarez-Fernández, Gabriela Muñoz Cordero, José Luis Llorente Pendás
INTRODUCTION: Over the past several decades, many acoustic parameters have been studied as sensitive to and to measure dysphonia. However, current acoustic measures might not be sensitive measures of perceived voice quality. A meta-analysis which evaluated the relationship between perceived overall voice quality and several acoustic-phonetic correlates, identified measures that do not rely on the extraction of the fundamental period, such the measures derived from the cepstrum, and that can be used in sustained vowel as well as continuous speech samples...
February 14, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28213996/three-dimensional-computed-tomography-for-preoperative-assessment-of-the-pulmonary-artery-in-patients-undergoing-endoscopic-lobectomy-or-segmentectomy
#4
Amaia Ojanguren, José Luis Recuero, Marina Pardina, Lucía Milla, Maite Santamaría
BACKGROUND: The interest for endoscopic pulmonary anatomic resections has grown exponentially during the last decade. During thoracoscopic procedures surgeons cannot rely on digital handling and operative field is viewed on a two-dimensional video monitor, thus frequently encountering anatomical difficulties. The hypothesis is that foreknowledge of the anatomy of each patient would greatly contribute to the safety and accuracy of the operation. The aim of the study was to evaluate the effectiveness of 3dimensional multidetector computed tomography (3D-MDCT) software to identify the pulmonary artery branching pattern during the preoperative study of endoscopic lobectomies and segmentectomies...
February 14, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28213856/inferior-vena-cava-system-anomalies-surgical-implications
#5
REVIEW
Javier González, Jeffrey J Gaynor, Luis F Albéniz, Gaetano Ciancio
PURPOSE OF REVIEW: The inferior vena cava (IVC) system is the major venous collecting blood network of the human body. This structure is formed in a complicated series of developmental stages between the fourth and eighth weeks of intrauterine life. Alterations in the developing process of the IVC system give rise to an array of different congenital variants or developmental anomalies. RECENT FINDINGS: IVC anomalies are uncommon, usually of little physiological consequence, and mostly discovered incidentally during cross-sectional imaging in otherwise healthy individuals...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28213845/topical-formulation-containing-beeswax-based-nanoparticles-improved-in-vivo-skin-barrier-function
#6
Carla Souza, Luis Alexandre Pedro de Freitas, Patrícia Maria Berardo Gonçalves Maia Campos
Lipid nanoparticles have shown many advantages for treatment/prevention of skin disorders with damaged skin barrier function. Beeswax is a favorable candidate for the development of nanosystems in the cosmetic and dermatological fields because of its advantages for the development of products for topical application. In the present study, beeswax-based nanoparticles (BNs) were prepared using the hot melt microemulsion technique and incorporated to a gel-cream formulation. The formulation was subsequently evaluated for its rheological stability and effect on stratum corneum water content (SCWC) and transepidermal water loss (TEWL) using in vivo biophysical techniques...
February 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28213779/adenoid-bacterial-colonization-in-a-paediatric-population
#7
João Subtil, João Carlos Rodrigues, Lúcia Reis, Luís Freitas, Joana Filipe, Alberto Santos, Carlos Macor, Aida Duarte, Luisa Jordao
Adenoids play a key role in both respiratory and ear infection in children. It has also been shown that adenoidectomy improves these symptoms in this population. The main goal of the present study was to evaluate adenoid bacterial colonization and document a possible relation with infectious respiratory disease. A prospective observational study was designed to evaluate the proposed hypothesis in a paediatric population submitted to adenoidectomy by either infectious or non-infectious indications and compare these two cohorts...
February 18, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28213765/association-between-signs-and-symptoms-of-bruxism-and-presence-of-tori-a-systematic-review
#8
Eduardo Bertazzo-Silveira, Juliana Stuginski-Barbosa, André Luís Porporatti, Bruce Dick, Carlos Flores-Mir, Daniele Manfredini, Graziela De Luca Canto
OBJECTIVE: This systematic review aims to answer the question: "Is there an association between any specific signs and symptoms of bruxism and the presence of tori?" MATERIAL AND METHODS: Observational studies, which evaluated the association between signs and symptoms of bruxism and tori, were selected. Signs and symptoms of bruxism (such as teeth grinding, jaw clenching, abnormal tooth wear, facial muscle hypertrophy, pain, or fatigue) had to be determined by questionnaire or anamnesis and tori within clinical assessment...
February 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28213244/a-novel-pyrogallol-red-based-assay-to-assess-catalase-activity-optimization-by-response-surface-methodology
#9
Mohamed Abderrahim, Silvia M Arribas, Luis Condezo-Hoyos
Pyrogallol red (PGR) was identified as a novel optical probe for the detection of hydrogen peroxide (H2O2) based on horseradish peroxidase (HRP)-catalyzed oxidation. Response surface methodology (RSM) was applied as a tool to optimize the concentrations of PGR (100µmolL(-1)), HRP (1UmL(-1)) and H2O2 (250µmolL(-1)) and used to develop a sensitive PGR-based catalase (CAT) activity assay (PGR-CAT assay). N-ethylmaleimide -NEM- (102mmolL(-1)) was used to avoid interference produced by thiol groups while protecting CAT activity...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213218/dynamic-flow-through-approach-to-evaluate-readily-bioaccessible-antioxidants-in-solid-food-samples
#10
Miguel A Maia, Tânia R P Soares, Ana I P Mota, María Rosende, Luís M Magalhães, Manuel Miró, Marcela A Segundo
Release of bioactive compounds from food matrices is regarded as the first step towards their human bioavailability. The objective of this work was the implementation of an affordable and robust flow-through device for expedient dynamic leaching experiments aiming at the assessment of readily bioaccessible antioxidant compounds in solid food commodities. A simple configuration is proposed using commercially available devices containing regenerated cellulose filters placed in polypropylene holders to entrap the solid sample, featuring a disposable, single use extraction chamber...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213011/calorie-restriction-promotes-cardiolipin-biosynthesis-and-distribution-between-mitochondrial-membranes
#11
Luis Alberto Luévano-Martínez, Maria Fernanda Forni, Julia Peloggia, Ii-Sei Watanabe, Alicia J Kowaltowski
Calorie restriction (CR) has been amply demonstrated to modify mitochondrial function. However, little is known regarding the effects of this dietary regimen on mitochondrial membranes. We isolated phospholipids from rat liver mitochondria from animals on CR or ad libitum diets and found that mitochondria from ad libitum animals present an increased content of lipoperoxides and the content of cardiolipin. Cardiolipin is the main anionic phospholipid present in mitochondrial membranes, and plays a key role in mitochondrial function, signaling and stress response...
February 14, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28212999/meta-analysis-examining-impact-of-age-on-overall-survival-with-pemetrexed-for-the-treatment-of-advanced-non-squamous-non-small-cell-lung-cancer
#12
Luis G Paz-Ares, Annamaria Zimmermann, Tudor Ciuleanu, Paul A Bunn, Belen San Antonio, Jonathan Denne, Nancy Iturria, William John, Giorgio V Scagliotti
OBJECTIVE: In clinical practice, elderly patients are often undertreated relative to younger patients. This meta-analysis was designed to determine whether older patients with non-squamous non-small cell lung cancer (NSCLC) could derive an overall survival (OS) benefit from pemetrexed treatment comparable to that experienced by younger patients in the first-line, second-line, or maintenance settings. METHODS: Data from 2671 patients with non-squamous NSCLC participating in four pemetrexed phase III studies were included in a meta-analysis using a random-effects model...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212979/degradation-of-optical-and-surface-properties-of-resin-based-composites-with-distinct-nanoparticle-sizes-but-equivalent-surface-area
#13
Vinícius Esteves Salgado, Larissa Maria Cavalcante, Rafael R Moraes, Harry B Davis, Jack L Ferracane, Luis Felipe Schneider
OBJECTIVE: To determine the optical and surface properties of model resin-based composites made with distinct nanoparticle sizes but equalized surface area, among them, before and after ageing. METHODS: Model resin-based composites based on BisGMA/TEGDMA (50:50mol%) were loaded with three different fumed silica filler content (7nm/examethyldisilazane, 12nm/octylsilane, and 16nm/dimethylchlorosilane), but with equivalent surface area (BET method). The optical and surface properties of the disk-shaped specimens were measured in 24h after photoactivation (baseline) and repeated after water storage (90days at 37°C), and after abrasion (20,000 cycles of brushing)...
February 14, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28212823/cyp-epoxygenase-derived-h2o2-is-involved-in-the-endothelium-derived-hyperpolarization-edh-and-relaxation-of-intrarenal-arteries
#14
Mercedes Muñoz, Maria Elvira López-Oliva, Estéfano Pinilla, María Pilar Martínez, Ana Sánchez, Claudia Rodríguez, Albino García-Sacristán, Medardo Hernández, Luis Rivera, Dolores Prieto
Reactive oxygen species (ROS) like hydrogen peroxide (H2O2) are involved in the in endothelium-derived hyperpolarization (EDH)-type relaxant responses of coronary and mesenteric arterioles. The role of ROS in kidney vascular function has mainly been investigated in the context of harmful ROS generation associated to kidney disease. The present study was sought to investigate whether H2O2 is involved in the endothelium-dependent relaxations of intrarenal arteries as well the possible endothelial sources of ROS generation involved in these responses...
February 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28212528/the-crispr-cas9%C3%A2-system-efficiently-reverts-the-tumorigenic-ability-of-bcr-abl-in-vitro-and-in-a-xenograft-model-of-chronic-myeloid-leukemia
#15
Ignacio García-Tuñón, María Hernández-Sánchez, José Luis Ordoñez, Veronica Alonso-Pérez, Miguel Álamo-Quijada, Rocio Benito, Carmen Guerrero, Jesús María Hernández-Rivas, Manuel Sánchez-Martín
CRISPR/Cas9 technology was used to abrogate p210 oncoprotein expression in the Boff-p210 cell line, a pro-B line derived from interlukin-3-dependent Baf/3, that shows IL-3-independence arising from the constitutive expression of BCR-ABL p210. Using this approach, pools of Boff-p210-edited cells and single edited cell-derived clones were obtained and functionally studied in vitro. The loss of p210 expression in Boff-p210 cells resulted in the loss of ability to grow in the absence of IL-3, as the Baf/3 parental line, showing significantly increased apoptosis levels...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212482/-using-polypropylene-mesh-in-surgery-for-stress-urinary-incontinence
#16
Erick Arturo Murguía-Flores, Fernando Quintero-Granados, Luis Guillermo Torres-Gómez, Mariela Mariela Chávez-Navarro, Martha Berenice Vázquez-Gómez, Elizabeth Rodríguez-Rodríguez
BACKGROUND: Stress urinary incontinence (SUI) is defined as the involuntary leakage of urine while making an effort, such as coughing, sneezing or during activity. Since SUI generates high costs and affects the quality of life, it is important to make a proper diagnosis and, consequently, manage SUI efficiently. The objective was to know whether it is appropriate to use polypropylene mesh for SUI. METHODS: A historical cohort was conducted by reviewing records of patients with SUI treated with polypropylene mesh during 2013 with a follow-up of 12 months...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28212472/-concordance-between-preoperative-and-definitive-study-in-endometrial-cancer
#17
Betania Mazón-González, Víctor Alberto Olguín-Cruces
BACKGROUND: Some studies have been realized to know the concordance level between the preoperative and the diagnosis of endometrial cancer and it has been observed that there is a tendency to undergrade the stage of cancer in preoperative studies. METHODS: It was carried out an observational, retrolective, transversal and comparative study to establish the concordance between the preoperative and the definitive study in endometrial cancer. We revised the records of the Pathology department of the Hospital "Luis Castelazo Ayala" from January 1st, 2012, to December 31th, 2014...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28212470/-prediabetes-as-a-riskmarker-for-stress-induced-hyperglycemia-in-critically-ill-adults
#18
Diego Jesús García-Gallegos, Eliseo Luis-López
BACKGROUND: It is not known if patients with prediabetes, a subgroup of non-diabetic patients that usually present hyperinsulinemia, have higher risk to present stress-induced hyperglycemia. The objective was to determine if prediabetes is a risk marker to present stress-induced hyperglycemia. METHODS: Analytic, observational, prospective cohort study of non-diabetic critically ill patients of a third level hospital. We determined plasmatic glucose and glycated hemoglobin (HbA1c) at admission to diagnose stress-induced hyperglycemia (glucose ≥ 140 mg/dL) and prediabetes (HbA1c between 5...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28212035/ultrafast-time-resolved-x-ray-absorption-spectroscopy-of-ferrioxalate-photolysis-with-a-laser-plasma-x-ray-source-and-microcalorimeter-array
#19
Galen C O'Neil, Luis Miaja-Avila, Young Il Joe, Bradley K Alpert, Mahalingam Balasubramanian, Dodderi M Sagar, William Bertrand Doriese, Joseph W Fowler, Wilfred K Fullagar, Ning Chen, Gene C Hilton, Ralph Jimenez, Bruce Ravel, Carl D Reintsema, Dan R Schmidt, Kevin L Silverman, Daniel S Swetz, Jens Uhlig, Joel N Ullom
The detailed pathways of photoactivity on ultrafast timescales are a topic of contemporary interest. Using a tabletop apparatus based upon a laser plasma x-ray source and an array of cryogenic microcalorimeter x-ray detectors, we have measured a transient x-ray absorption spectrum during the ferrioxalate photoreduction reaction. With these high efficiency detectors we observe the Fe K edge move to lower energies, and the amplitude of the extended x-ray absorption fine structure reduce, consistent with a photoreduction mechanism in which electron transfer precedes disassociation...
February 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28212023/electrostatic-assembly-of-functional-and-macromolecular-ferricinium-chloride-stabilized-gold-nanoparticles
#20
Roberto Ciganda, Haibin Gu, Ricardo Hernandez, Ane Escobar, Angel Martínez, Luis Yates, Sergio Moya, Jaime Ruiz, Didier Astruc
Substituted ferrocenes with various stereoelectronic effects including a ferrocene-terminated dendrimer in ether reduce aqueous HAuCl4 to gold nanoparticles (AuNPs) by interfacial electron transfer. The dependence on the stirring speed plays a crucial role, and the stereoelectronic influences on the reaction rates are dramatic. With a ferrocene-containing polymer, the reaction is conducted using an homogeneous THF/water medium, also forming AuNPs. Fully stable functional, dendritic and polymeric ferricinium chloride-stabilized AuNPs are obtained with core sizes between 13 and 35 nm, an optimal size range for potential biomedical applications...
February 17, 2017: Inorganic Chemistry
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