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https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#1
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29219281/impact-on-sexual-function-of-surgical-treatment-in-rectal-cancer
#2
Pedro Costa, João M Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
INTRODUCTION: The development of new surgical techniques and medical devices, like therapeutical multimodal approaches has allowed for better outcomes on patients with rectal cancer (RCa). Owing to that, an increased awareness and investment towards better outcomes regarding patients' sexual and urinary function has been recently observed. AIM: Evaluate and characterize the sexual dysfunction of patients submitted to surgical treatment for RCa. MATERIALS AND METHODS: An observational retrospective study including all male patients who underwent a surgical treatment for RCa between January 2011 December 2014 (n=43) was performed, complemented with an inquiry questionnaire to every patient about its sexual habits and level of function before and after surgery...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29214148/comparison-of-functional-outcome-after-extended-versus-super-extended-pelvic-lymph-node-dissection-during-radical-prostatectomy-in-high-risk-localized-prostate-cancer
#3
Heikki Seikkula, Pieter Janssen, Manuela Tutolo, Lorenzo Tosco, Antonino Battaglia, Lisa Moris, Thomas Van den Broeck, Maarten Albersen, Gert De Meerleer, Hendrik Van Poppel, Wouter Everaerts, Steven Joniau
Background: Urinary continence and erectile function (EF) are best preserved when meticulous dissection of prostate and nerve sparing technique are used during radical prostatectomy (RP). However, extent of lymph node dissection (LND) may also adversely affect functional results. Objective: To determine whether performing a super-extended LND (seLND) has a significant effect on recovery of urinary continence and EF after RP. Design setting and participants: All patients who underwent RP from January 2007 until December 2013 were handed questionnaires assessing continence and EF...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29213346/safe-plastic-surgery-of-the-breast-ii-saving-nipple-sensation
#4
Steven Schulz, Matthew R Zeiderman, J Stephen Gunn, Charles A Riccio, Saeed Chowdhry, Ronald Brooks, Joshua H Choo, Bradon J Wilhelmi
Background: Since its inception, reduction mammoplasty has matured considerably. Primary evolution in clinical research and practice initially focused on developing techniques to preserve tissue viability; breast parenchyma, skin, and nipple tissue that has expanded to include sensation and erectile function play a large role in the physical intimacy of women. Studies regarding primary innervation to the nipple are few and often contradictory. Our past anatomical study demonstrated that primary innervation to the nipple to come from the lateral branch of the fourth intercostal nerve...
2017: Eplasty
https://www.readbyqxmd.com/read/29212979/-clinical-features-and-quality-of-life-assessment-in-japanese-pnh-patients-enrolled-in-the-international-pnh-registry
#5
Masatoshi Sakurai, Shinichiro Okamoto
The aim of the present study was to clarify the clinical characteristics and quality of life (QOL) of Japanese patients (N=116) enrolled in the International PNH Registry, compared to the whole registry cohort (N=3,457), censored as of March 2015. The proportion of patients treated with eculizumab was comparable between the two cohorts; the Japanese cohort showed higher levels of lactate dehydrogenase and lower hemoglobin values at baseline. Compared to the whole cohort, the Japanese cohort had a greater incidence of bone marrow failure (67...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29212232/the-effects-of-fk1706-on-nerve-regeneration-and-bladder-function-recovery-following-an-end-to-side-neurorrhaphy-in-rats
#6
Wansheng Gao, Xiangfei He, Yunlong Li, Jianguo Wen
Background: Immunophilin ligands are neuroregenerative agents binding to FK506 binding proteins, by which stimulate recovery of neurons in a variety of injury nerves. FK1706 is a novel immunophilin ligand which has neuroprotective and neuroregenerative effects but without immunosuppressive activity. At present, most reports about FK1706 in ameliorating nerve injury and functional recovery are limited to cavernous nerve injury and erectile function recovery. This study aimed to demonstrate the effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rat models...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211402/sonographic-patterns-of-peyronie-s-disease-in-patients-with-absence-of-palpable-plaques
#7
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Non-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature. MATERIALS AND METHODS: We reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29210883/association-between-pain-and-sexual-health-in-older-people-results-from-the-english-longitudinal-study-of-ageing
#8
Katie Wade, Frederick C W Wu, Terence W O'Neill, David M Lee
There is little information on the impact of pain on sexual health in later life. The aim of this analysis was to determine the association between self-reported pain and sexual health in older men and women.Data were collected for the nationally representative English Longitudinal Study of Ageing. Community-dwelling adults aged 50 years and older completed the Sexual Relationships and Activities questionnaire in wave 6 (2012/2013). Participants were asked (waves 1 to 6 [2002-2013]) if they were 'often troubled with pain' and, how severe was their pain; mild, moderate or severe...
November 25, 2017: Pain
https://www.readbyqxmd.com/read/29204160/does-supplemental-external-beam-radiation-therapy-impact-urinary-bowel-and-erectile-function-following-permanent-prostate-brachytherapy-results-of-two-prospective-randomized-trials
#9
Gregory S Merrick, Ava Tennant, Kent E Wallner, Robert Galbreath, Wayne M Butler, Ryan Fiano, Edward Adamovich
Purpose: To evaluate the impact of supplemental external beam radiation therapy (EBRT) prior to permanent prostate brachytherapy on long term urinary, bowel, and erectile function. Material and methods: Patient administered urinary, bowel, and erectile quality of life (QoL) instrument were obtained prior to treatment and following brachytherapy. The study population was comprised of the 457 patients who were alive as of June 2016, had been randomized to two markedly different supplemental EBRT dose regimens and a third arm without supplemental EBRT, and had completed the June 2016 QoL survey...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29203844/complications-functional-and-quality-of-life-outcomes-following-primary-and-secondary-implantation-of-penile-prosthesis-at-a-tertiary-referral-center
#10
Bernhard Ralla, Irena Goranova, Niels Börnstein, Frank Friedersdorff, Andreas Maxeiner, Ahmed Magheli, Stefan Hinz, Joerg Neymeyer, Kurt Miller, Jonas Busch
The implantation of a penile prosthesis (PP) may be recommended in patients with severe erectile dysfunction (ED) who do not respond to conservative treatments. The aim of this study was to evaluate complications, as well as functional and quality of life outcomes following primary and secondary implantation of PP at a tertiary referral center. In this retrospective study, a total of 51 patients (41 patients with primary (PPP) and 10 with secondary PP (SPP)) were included. Patients and operative characteristics were recorded and complications were analyzed using the Clavien-Dindo classification...
December 4, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29203189/inhibition-of-jun-n-terminal-kinase-jnk-improves-erectile-function-by-alleviation-of-cavernosal-apoptosis-in-a-rat-model-of-cavernous-nerve-injury
#11
Juhyun Park, Ji Sun Chai, Soo Woong Kim, Jae-Seung Paick, Min Chul Cho
OBJECTIVE: To determine whether JNK inhibition could alleviate erectile dysfunction (ED) through suppressing cavernosal apoptosis in a rat model of carvernosal nerve crush injury (CNCI), thereby providing potential therapeutic strategy for alleviating post-radical prostatectomy (RP) ED. MATERIALS AND METHODS: Fifty-six 11-week-old male Sprague-Dawley rats were categorized equally into the following four groups: 1) sham surgery (S), 2) CNCI (I), 3) CNCI treated with low-dose JNK inhibitor (L), and 4) CNCI treated with high-dose JNK inhibitor (H)...
December 1, 2017: Urology
https://www.readbyqxmd.com/read/29201505/is-there-a-relation-between-priapism-occurring-after-penile-doppler-ultrasonography-and-international-erectile-function-index-score-and-erection-hardness-score-levels
#12
Mehmet Giray Sönmez, Ahmet Öztürk
Objective: The relation between Erection Hardness Score (EHS) and The International Erectile Function Index (IIEF) Questionnaire- Erectile Function Domain Score (IIEF-EF score) used in erectile dysfunction (ED) evaluation and the prevalence of priapism after penile Doppler ultrasonography (PDU) was examined in this study. Material and methods: A total of 62 patients who had PDU were included in the study. Patients were divided into two groups; there were 33 patients in IIEF-EF score ≤10, EHS <2 group (Group 1) and 29 patients in IIEF-EF score >10, EHS ≥2 group (Group 2)...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29200555/erectile-dysfunction-an-underestimated-presentation-in-patients-with-diabetes-mellitus
#13
Zeeshan Anwar, Vishal Sinha, Sayantanava Mitra, Ashwani Kumar Mishra, Mahboobul Hasan Ansari, Abhishek Bharti, Vipin Kumar, Ashwini Kumar Nigam
Introduction: Erectile dysfunction (ED) is a common complication of diabetes mellitus. ED, like other sexual disorders, is often under-reported and under-diagnosed, as talking about sex is considered a taboo in our society. Methodology: All the male patients with diabetes mellitus (with or without active complaints of ED) attending Medicine or Psychiatry OPD of the institute during the study period were enrolled in the study. They were investigated for their body-mass index (BMI), blood sugar and lipid profile; and were assessed on HAM-D, General Health Questionnaire-30, IIEF, sex myth checklist and QOL Instrument for Indian Diabetes Patients (QOLID)...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29199538/the-truth-beneath-the-taste-roses-in-the-urethra-and-first-description-of-neuro-morpho-chemical-mechanism-of-penile-erectil-posture-in-males-an-experimental-study
#14
Mehmet Dumlu Aydın, Nazan Aydın, Ayhan Kanat, Nezih Akca, Gizem Ardic, Coskun Yolas, Konca Altınkaynak, Muhammet Calik
AIMS: The morphologic mechanism of orgasmic sensation has not yet been understood. Taste roseas may be stimulated by fructose via pudendal nerve which has not been studied yet. METHODS: In this study, 27 male adult rabbits were used, and divided into three groups, five as control; five as SHAM and seventeen used as study group. We injected 0.2cc of distilled water to SHAM and 0.2cc of fructose solution to Study Group of their uretralorifices, examined the occurrence of penile erection...
December 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29198514/erectile-dysfunction-medications-and-treatment-for-cardiometabolic-risk-factors-a-pharmacoepidemiologic-study
#15
Sean C Skeldon, Lucy Cheng, Steven G Morgan, Allan S Detsky, S Larry Goldenberg, Michael R Law
BACKGROUND: Erectile dysfunction (ED) can be a sentinel marker for future cardiovascular disease and has been described as providing a "window of curability" for men to receive targeted cardiovascular risk assessment. AIM: To determine whether the prescription of phosphodiesterase type 5 inhibitors (PDE5is) for ED leads to the detection and treatment of previously undiagnosed cardiometabolic risk factors. METHODS: We performed a retrospective population-based cohort study of residents of British Columbia, Canada using linked health care databases from 2004 to 2011...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198510/does-calculated-free-testosterone-overcome-total-testosterone-in-protecting-from-sexual-symptom-impairment-findings-of-a-cross-sectional-study
#16
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Donatella Moretti, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
BACKGROUND: Although erectile dysfunction (ED) has been associated with low circulating total testosterone (TT) levels, the utility of free testosterone (FT) over TT is debatable. AIM: To assess the relative impact of low TT and low calculated FT (cFT) on androgen-related sexual symptoms in men with ED. METHODS: Data from 485 men were analyzed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the International Index of Erectile Function (IIEF) and the Beck Inventory for Depression (BDI)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198509/testosterone-deficiency-causes-endothelial-dysfunction-via-elevation-of-asymmetric-dimethylarginine-and-oxidative-stress-in-castrated-rats
#17
Tomoya Kataoka, Yuji Hotta, Yasuhiro Maeda, Kazunori Kimura
BACKGROUND: Testosterone is believed to mediate the penile erectile response by producing adequate nitric oxide; therefore, testosterone deficiency results in erectile dysfunction through decreased nitric oxide bioavailability. However, the mechanisms underlying endothelial dysfunction in testosterone deficiency remain unclear. AIM: To investigate the mechanism of endothelial dysfunction in a rat model of testosterone deficiency. METHODS: Rats were distributed into 3 groups: castrated (Cast), castrated and supplemented with testosterone (Cast + T), and sham (Sham)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198508/the-g-spot-is-not-a-structure-evident-on-macroscopic-anatomic-dissection-of-the-vaginal-wall
#18
Nathan Hoag, Janet R Keast, Helen E O'Connell
BACKGROUND: Controversy exists in the literature regarding the presence or absence of an anatomic "G-spot." However, few studies have examined the detailed topographic or histologic anatomy of the putative G-spot location. AIM: To determine the anatomy of the anterior vaginal wall and present detailed, systematic, accessible findings from female cadaveric dissections to provide anatomic clarity with respect to this location. METHODS: Systematic anatomic dissections were performed on 13 female cadavers (32-97 years old, 8 fixed and 5 fresh) to characterize the gross anatomy of the anterior vaginal wall...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29196694/latent-tuberculosis-infection-among-patients-with-erectile-dysfunction
#19
Ahmad F A Hasanain, Ali M A Mahran, Ahmed S Safwat, Amany M A Nafee, Ali A H Zayed, Sherif M Abdel-Aal, Sally M Bakkar, Ahmad Elbadry I Abonnoor
No previous studies have investigated the prevalence of latent tuberculosis infection (LTBI) among patients with erectile dysfunction (ED) or its contribution to the development of high-grade ED through a process of chronic inflammation-induced atherosclerosis. The aim of this study was to determine the frequency of LTBI among patients with erectile dysfunction and to explore the contribution of LTBI to high-grade ED. For all the study sample, clinical evaluation, imaging studies, and laboratory investigations were provided...
December 1, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29196693/relationship-between-erectile-dysfunction-and-the-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios
#20
Murat Sambel, Metin Kilic, Murat Demirbas, Efe Onen, Sedat Oner, Abdullah Erdogan, Mustafa Murat Aydos
The most important cause of erectile dysfunction (ED) among aging men is organic disease due to vascular disturbance that is often caused by atherosclerosis. Recently, studies have shown that atherosclerosis can manifest as an active inflammatory process rather than as passive vascular injury caused by lipid infiltration. Our study aimed to examine the association of ED with the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR), both of which are markers of inflammation. Between December 2014 and May 2015, 101 male patients aged 40-70 years who were seen at our institute due to ED were included in this study...
December 1, 2017: International Journal of Impotence Research
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