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osteoarthritys

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https://www.readbyqxmd.com/read/29220376/c5a-and-c5ar-are-elevated-in-joints-of-rheumatoid-and-psoriatic-arthritis-patients-and-c5ar-blockade-attenuates-leukocyte-migration-to-synovial-fluid
#1
Lars Hornum, Anker Jon Hansen, Ditte Tornehave, Marianne Scheel Fjording, Paula Colmenero, Inger Falbe Wätjen, Niels Henrik Søe Nielsen, Henning Bliddal, Else Marie Bartels
Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this study was to investigate the role of C5a and C5aR in human rheumatoid arthritis and psoriatic arthritis-both with respect to expression and function. Synovial fluid, blood and synovial samples were obtained from rheumatoid arthritis, psoriatic arthritis and osteoarthritis patients as a less inflammatory arthritis type, and blood from healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/29218448/how-does-spa-treatment-affect-cardiovascular-function-and-vascular-endothelium-in-patients-with-generalized-osteoarthritis-a-pilot-study-through-plasma-asymmetric-di-methyl-arginine-adma-and-l-arginine-adma-ratio
#2
Fatih Karaarslan, Kagan Ozkuk, Serap Seringec Karabulut, Seldag Bekpinar, Mufit Zeki Karagulle, Nergis Erdogan
The study aims to investigate the effect of spa treatment on vascular endothelium and clinical symptoms of generalized osteoarthritis. Forty generalized osteoarthritis (GOA) patients referred to a government spa hospital, and 40 GOA patients followed on university hospital locomotor system disease ambulatory clinics were included as study and control groups, respectively. Study group received spa treatment including thermal water baths, physical therapy modalities, and exercises. Control group was followed with home exercises for 15 days...
December 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29218229/the-role-of-arthroereisis-of-the-subtalar-joint-for-flatfoot-in-children-and-adults
#3
REVIEW
Alessio Bernasconi, François Lintz, Francesco Sadile
Subtalar arthroereisis has been reported as a minimally-invasive, effective and low-risk procedure in the treatment of flatfoot mainly in children but also in adults.It has been described as a standalone or adjunctive procedure, and is indicated in the treatment of flexible flatfoot, tibialis posterior tendon dysfunction, tarsal coalition and accessory navicular syndrome.Different devices for subtalar arthroereisis are currently used throughout the world associated with soft-tissue and bone procedures, depending on the surgeon rather than on standardised or validated protocols...
November 2017: EFORT Open Reviews
https://www.readbyqxmd.com/read/29218121/characteristics-of-chronic-pain-patients-attending-a-primary-health-care-center-in-oman
#4
Nasrin Al-Zadjali, Samia Al-Khaldi, Nafisa Samir, Syed Rizvi, Ibrahim Al-Zakwani, Abdulaziz Al-Mahrezi
Objectives: To determine the characteristics of patients presenting with chronic pain in a primary health care setting in Oman. Methods: A retrospective cross-sectional study was carried out including all patients aged ≥ 18 years who attended Sultan Qaboos University Health Center during 2010. Patients were identified to have chronic pain if they were prescribed an analgesic medication for at least three months. Patients were compared to a control group which consisted of age- and gender-matched patients with no chronic pain...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29218077/long-noncoding-rnas-a-new-regulatory-code-in-osteoarthritis
#5
REVIEW
Xiao Cen, Xin-Qi Huang, Wen-Tian Sun, Qing Liu, Jun Liu
It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA process. This review summarized the lncRNAs identified in OA to date, discussed their influence on the survival of chondrocytes and synoviocytes, arthritis-associated factors, and angiogenesis, and indicated the potential in diagnosis, therapy, and prognosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217393/acetabular-revision-using-trabecular-metal-augments-for-paprosky-type-3-defects
#6
Cathleen J O'Neill, Stephen B Creedon, Stephen A Brennan, Fiona J O'Mahony, Rosanne S Lynham, Shane Guerin, Rehan Gul, James A Harty
BACKGROUND: Trabecular Metal (TM) augments are one option when reconstructing bone loss during acetabular side revision surgery. METHODS: We studied 38 consecutive patients with Paprosky type 3 defects that were revised using a TM shell and one or more augments over a 6-year period. There were 29 Paprosky type 3A defects and 9 Paprosky type 3B defects. The mean age of the patients at the time of surgery was 68.2 years (range 48-84). The mean length of follow-up was 36 months (range 18-74)...
December 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29216915/rheumatoid-arthritis-bone-marrow-environment-supports-th17-response
#7
Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Plebańczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik, Włodzimierz Maśliński
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from "outside the joint" can occur. IL-17 is a cytokine that exerts proinflammatory effects and participates in the process of bone destruction. It is believed that IL-17 is involved in pathogenesis of RA. However, little is known about the biology of this cytokine in BM. In the present study we investigated Th17-related cytokines in RA BM...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29216898/is-the-relationship-between-increased-knee-muscle-strength-and-improved-physical-function-following-exercise-dependent-on-baseline-physical-function-status
#8
Michelle Hall, Rana S Hinman, Martin van der Esch, Marike van der Leeden, Jessica Kasza, Tim V Wrigley, Ben R Metcalf, Fiona Dobson, Kim L Bennell
BACKGROUND: Clinical guidelines recommend knee muscle strengthening exercises to improve physical function. However, the amount of knee muscle strength increase needed for clinically relevant improvements in physical function is unclear. Understanding how much increase in knee muscle strength is associated with improved physical function could assist clinicians in providing appropriate strength gain targets for their patients in order to optimise outcomes from exercise. The aim of this study was to investigate whether an increase in knee muscle strength is associated with improved self-reported physical function following exercise; and whether the relationship differs according to physical function status at baseline...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29214949/-a-review-on-psychosomatic-factors-affecting-the-outcome-after-total-knee-arthroplasty-tka
#9
Matthias Vogel, Christian Riediger, Sebastian Illiger, Jörg Frommer, Christoph H Lohmann
A review on psychosomatic factors affecting the outcome after total knee-arthroplasty (TKA) Objectives: In today's ageing Western societies, arthroplasty is a common treatment for endstage osteoarthritis. Despite highly developed implants and surgery, however, this treatment does not always succeed in relieving pain and restoring joint function, i.e., in restoring satisfactory algofunction. Clinicians partly blame psychological factors for this discrepancy, especially in the absence of objective medical complications...
December 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/29214918/effects-of-knee-orthosis-adjustment-on-biomechanical-performance-and-clinical-outcome-in-patients-with-medial-knee-osteoarthritis
#10
Andreas Brand, Isabella Klöpfer-Krämer, Mario Morgenstern, Inga Kröger, Björn Michel, Andreas Thannheimer, Janina Anna Müßig, Peter Augat
BACKGROUND: Valgus bracing in medial knee osteoarthritis aims to improve gait function by reducing the loading of the medial compartment. Orthosis composition and optimal adjustment is essential to achieve biomechanical and clinical effectiveness. OBJECTIVES: To investigate biomechanical functionality during gait, pain relief and compliance in patients with knee osteoarthritis using a lightweight adjustable knee unloader orthosis. STUDY DESIGN: Prospective observational clinical trial...
December 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29214616/a-randomized-controlled-trial-evaluating-methylsulfonylmethane-versus-placebo-to-prevent-knee-pain-in-military-initial-entry-trainees
#11
David J Tennent, Christina M Hylden, Benjamin K Kocher, James K Aden, Anthony E Johnson
BACKGROUND: Methylsulfonylmethane (MSM) is a naturally occurring sulfur containing substance that has been shown to have anti-inflammatory and antioxidative properties. Previous studies using MSM as an oral supplement to improve pain in those patients with knee osteoarthritis have shown superiority compared to placebo. However, these studies are not translatable to active individuals performing high impact activities and have not evaluated MSM as a preventative measure. METHODS: A total of 180 subjects ranging in age from 18 to 40 years were enrolled...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29214554/geniposide-suppresses-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-chondrocytes-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#12
Tianlong Pan, Xuchao Shi, Huan Chen, Rong Chen, Dengying Wu, Zeng Lin, Jingdong Zhang, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is principally characterized by progressive joint dysfunction and cartilage degradation. Inflammation and apoptosis play critical roles in the progression of OA. Geniposide (GPO), one of the principal components of the fruit of Gardenia jasminoides Ellis, has been reported to have anti-inflammatory and other pharmacological effects. In this study, we performed in vitro experiments on rat chondrocytes to examine the therapeutic effects of GPO on OA and investigated its effects in vivo in a rat model of OA induced by medial meniscal tear (MMT)...
December 6, 2017: Inflammation
https://www.readbyqxmd.com/read/29214143/the-potential-of-micrornas-for-stem-cell-based-therapy-for-degenerative-skeletal-diseases
#13
REVIEW
Emma Budd, Shona Waddell, María C de Andrés, Richard O C Oreffo
Purpose of Review: Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset...
2017: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/29214090/bone-resection-for-isolated-ulnar-head-fracture
#14
Hiromasa Akino, Shunpei Hama, Masataka Yasuda, Kenta Minato, Masahiro Miyashita
Distal ulnar fractures often occur with distal radius fractures (DRFs), and ulnar styloid fractures commonly occur in the setting of DRF. However, isolated ulnar head fractures are rare. We report a case of isolated ulnar head fracture in which we performed bone resection because the ulnar head bone fragment fractured when internal screw fixation was attempted. His outcome at 18 months postoperatively was considered excellent. However, we do not advocate bone resection other than failure of fixation and the difficult case to perform internal fixation...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29213100/altered-spontaneous-calcium-signaling-of-in-situ-chondrocytes-in-human-osteoarthritic-cartilage
#15
Xiaoyuan Gong, Wenbin Xie, Bin Wang, Lingchuan Gu, Fuyou Wang, Xiang Ren, Cheng Chen, Liu Yang
Intracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, we investigated the spatiotemporal features of spontaneous [Ca2+]i signaling in in situ chondrocytes at different OA stages. Our data showed zonal dependent spontaneous [Ca2+]i signaling in healthy cartilage samples under 4 mM calcium environment...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212997/-the-effects-of-pain-coping-skills-training-among-older-outpatients-with-osteoarthritis
#16
Yasuhiro Nagasawa, Koichiro Oka, Ai Shibata
AIM: The present study examined the effects of individual pain coping-skills training (PCST) on knee pain, pain coping strategies, physical functions, and daily physical activity among older outpatients with osteoarthritis. METHODS: Twenty-five older adults who suffered from knee pain and had been diagnosed to have knee osteoarthritis (men: n=4; 75.4±6.3 years) were assigned to either a PCST group (n=13) or a general health education group (n=12) according to their wishes...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29212681/ten-year-follow-up-study-of-three-alternative-bearing-surfaces-used-in-total-hip-arthroplasty-in-young-patients-a-prospective-randomised-controlled-trial
#17
A Atrey, S E Ward, A Khoshbin, N Hussain, E Bogoch, E H Schemitsch, J P Waddell
AIMS: We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface. PATIENTS AND METHODS: A total of 102 hips (91 patients) were randomised into the three groups...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212625/use-of-tricortical-iliac-crest-strut-autograft-in-comminuted-posterior-wall%C3%A2-acetabular-fractures-a-case-series
#18
Sandeep Gupta, Naveen Mittal, Jagandeep Singh Virk
PURPOSE: The results for fixation of comminuted posterior wall acetabular fractures are not very promising with reported complications in terms of osteoarthritis, nonunion and malunion which subsequently require conversion to total hip arthroplasty. The conversion to total hip arthroplasty is possible in patients over 50 years of age but not in younger patients. So this requires new methods for salvage of the native hip in young patients. METHODS: There were six patients in our series with highly comminuted posterior wall acetabular fractures where the fragments were excised and the gap filled with tricortical anterior iliac-crest strut autograft, fixed with screws and plate...
November 6, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29212511/comparing-the-chinese-versions-of-two-knee-specific-questionnaires-ikdc-and-koos-reliability-validity-and-responsiveness
#19
Chien-Chih Huang, Wen-Shiang Chen, Mei-Wun Tsai, Wendy Tzyy-Jiuan Wang
BACKGROUND: The International Knee Documentation Committee Subjective Knee Form (IKDC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) are knee-specific questionnaires that have been widely used and translated into numerous languages. However, the differences in the psychometric properties between the Chinese IKDC and KOOS remain unclear. The purpose of this study was to conduct a cross-cultural adaptation of the Chinese IKDC and Chinese KOOS and to compare the psychometric properties of these two measures in patients with various knee injuries from the acute stage up to 12 weeks after receiving treatment...
December 6, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29212436/estimation-of-individual-thigh-muscle-volumes-from-a-single-slice-muscle-cross-sectional-area-and-muscle-thickness-using-magnetic-resonance-imaging-in-patients-with-knee-osteoarthritis
#20
Koun Yamauchi, Akito Yoshiko, Shigetoshi Suzuki, Chisato Kato, Hiroshi Akima, Takayuki Kato, Koji Ishida
PURPOSE: This study aimed to identify the best single-slice anatomical muscle cross-sectional area (CSA) and muscle thickness (MT) on magnetic resonance imaging (MRI) to estimate the overall individual muscle volumes (MVs) of knee extensors and flexors in patients with knee osteoarthritis (KOA). METHODS: Twelve patients (24 legs; 4 men and 8 women) with KOA underwent a 1.5-Tesla axial MRI scan in the femoral region of interest (ROI), between the lesser trochanter and rectus femoris tendon...
September 2017: Journal of Orthopaedic Surgery
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