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https://www.readbyqxmd.com/read/27911695/dengue-virus-isolation-in-mosquito-aedes-albopictus-captured-during-an-outbreak-in-tokyo-2014-by-a-method-relying-on-antibody-dependent-enhancement-mechanism-using-fc%C3%AE-r-expressing-bhk-cells
#1
Meng Ling Moi, Daisuke Kobayashi, Haruhiko Isawa, Toshinori Sasaki, Masayuki Saijo, Ichiro Kurane, Kyoko Sawabe, Tomohiko Takasaki
Dengue virus (DENV) isolation from mosquitoes is necessary for providing definitive evidence of virus circulation, and is critical for further virological characterization and determination of epidemiological characteristics. By using Aedes albopictus mosquitoes captured during an outbreak in Tokyo in 2014, we compared the DENV isolation rates of a conventional virus isolation method that uses C6/36 mosquito cells as assay cells with those of a virus isolation method that relies on an antibody-dependent enhancement (ADE) mechanism by using FcγR-expressing baby hamster kidney (BHK) cells and an antibody with ADE activity...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27892796/using-a-divided-attention-stepping-accuracy-task-to-improve-balance-and-functional-outcomes-in-an-individual-with-incomplete-spinal-cord-injury-a-case-report
#2
Susan J Leach, Richard A Magill, Joyce R Maring
A spinal cord injury (SCI) frequently results in impaired balance, endurance, and strength with subsequent limitations in functional mobility and community participation. The purpose of this case report was to implement a training program for an individual with a chronic incomplete SCI using a novel divided-attention stepping accuracy task (DASAT) to determine if improvements could be made in impairments, activities, and participation. The client was a 51-year-old male with a motor incomplete C4 SCI sustained 4 years prior...
November 28, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27863275/cytoarchitecture-of-zika-virus-infection-in-human-neuroblastoma-and-aedes-albopictus-cell-lines
#3
Danielle K Offerdahl, David W Dorward, Bryan T Hansen, Marshall E Bloom
The Zika virus (ZIKV) pandemic is a global concern due to its role in the development of congenital anomalies of the central nervous system. This mosquito-borne flavivirus alternates between mammalian and mosquito hosts, but information about the biogenesis of ZIKV is limited. Using a human neuroblastoma cell line (SK-N-SH) and an Aedes albopictus mosquito cell line (C6/36), we characterized ZIKV infection by immunofluorescence, transmission electron microscopy (TEM), and electron tomography (ET) to better understand infection in these disparate host cells...
November 15, 2016: Virology
https://www.readbyqxmd.com/read/27843681/successful-surgical-strategy-for-a-cervical-hemangioblastoma-case-report
#4
Hideaki Imai, Kazuhiko Ishii, Hirotaka Chikuda, Junichi Ohya, Daichi Nakagawa, Tomomasa Kondo, Seiji Nomura, Masanori Yoshino, Satoru Miyawaki, Taichi Kin, Hirofumi Nakatomi, Nobuhito Saito
BACKGROUND: Hemangioblastomas are hypervascular lesions and hence their surgical management is challenging. In particular, if complete resection is to be attained, all feeding and draining vessels must be occluded. Although most intramedullary spinal cord tumors are treated utilizing a posterior approach, we describe an anterior surgical strategy for resection of an intramedullary cervical hemangioblastoma. CASE DESCRIPTION: A 36-year-old female with a spinal hemangioblastoma located in the anterior cervical spinal cord presented with a long-standing history of motor weakness of the right upper extremity...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27793242/spinal-injection-of-local-anesthetic-during-cervical-facet-joint-injection
#5
Juan A Ramos
INTRODUCTION: Facet joint pain is a common source of non-radicular back pain worldwide. Non-surgical interventional modalities remain the mainstay in the treatment of facetogenic back pain and comprise the second most commonly performed interventional pain procedures in the USA. CASE: A 36 year-old man with chronic cervical pain secondary to C6-C7 facet arthrosis radiographically, underwent diagnostic local anesthetic bilateral facet joint injection under fluoroscopic guidance...
November 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27714299/characterisation-of-6-dmatsmo-from-micromonospora-olivasterospora-leading-to-identification-of-the-divergence-in-enantioselectivity-regioselectivity-and-multiple-prenylation-of-tryptophan-prenyltransferases
#6
Julia Winkelblech, Xiulan Xie, Shu-Ming Li
Prenylated secondary metabolites including indole derivatives usually demonstrate improved biological and pharmacological activities, which make them promising candidates for drug discovery and development. The transfer reactions of a prenyl moiety from a prenyl donor, e.g. dimethylallyl diphosphate (DMAPP), to an acceptor is catalysed by prenyltransferases. One special group of such enzymes uses DMAPP and tryptophan as substrates with dimethylallyltryptophans as reaction products and functions therefore as dimethylallyltryptophan synthases (DMATSs)...
October 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27671777/bustos-virus-a-new-member-of-the-negevirus-group-isolated-from-a-mansonia-mosquito-in-the-philippines
#7
Ryosuke Fujita, Ryusei Kuwata, Daisuke Kobayashi, Arlene Garcia Bertuso, Haruhiko Isawa, Kyoko Sawabe
We isolated two distinct viruses from mosquitoes collected in Bustos, Bulacan province, Philippines, in 2009. These viruses show rapid replication and strong cytopathic effects in mosquito C6/36 cells. Whole-genome analysis of these viruses demonstrated that both viruses belong to the negevirus group. One of the viruses, from Culex vishunui mosquitoes, is a new strain of Negev virus. The other virus, from a Mansonia sp. mosquito, is a new negevirus designated Bustos virus. Gene expression analysis of the Bustos virus revealed that infected cells contain viral subgenomic RNAs that probably include open reading frame (ORF) 2 or ORF3...
September 26, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27639082/exenatide-improves-both-hepatic-and-adipose-tissue-insulin-resistance-a-dynamic-pet-study
#8
Amalia Gastaldelli, Melania Gaggini, Giuseppe Daniele, Demetrio Ciociaro, Eugenio Cersosimo, Devjit Tripathy, Curtis Triplitt, Peter Fox, Nicolas Musi, Ralph DeFronzo, Patricia Iozzo
: GLP-1 receptor agonists (GLP-1-RAs) act on multiple tissues, in addition to the pancreas. Recent studies suggest that GLP-1-RAs act on liver and adipose tissue to reduce insulin resistance (IR). Thus, we evaluated the acute effects of exenatide (EX) on hepatic (Hep-IR) and adipose (Adipo-IR) insulin resistance and glucose uptake. 15 male subjects (age=56±8 y, BMI=29±1 kg/m(2) , A1c=5.7±0.1%) were studied on two occasions, with a double blind subcutaneous injection of exenatide (5 mcg) or placebo (PLC) 30 min before a 75-gram oral glucose tolerance test (OGTT)...
September 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27604771/anabolic-sensitivity-of-postprandial-muscle-protein-synthesis-to-the-ingestion-of-a-protein-dense-food-is-reduced-in-overweight-and-obese-young-adults
#9
Joseph W Beals, Richard A Sukiennik, Julian Nallabelli, Russell S Emmons, Stephan van Vliet, Justin R Young, Alexander V Ulanov, Zhong Li, Scott A Paluska, Michael De Lisio, Nicholas A Burd
BACKGROUND: Excess body fat diminishes muscle protein synthesis rates in response to hyperinsulinemic-hyperaminoacidemic clamps. However, muscle protein synthetic responses after the ingestion of a protein-dense food source across a range of body mass indexes (BMIs) have not been compared. OBJECTIVE: We compared the myofibrillar protein synthetic response and underlying nutrient-sensing mechanisms after the ingestion of lean pork between obese, overweight, and healthy-weight adults...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27581122/ultrastructure-of-zika-virus-particles-in-cell-cultures
#10
Debora Ferreira Barreto-Vieira, Ortrud Monika Barth, Marcos Alexandre Nunes da Silva, Carolina Cardoso Santos, Aline da Silva Santos, Joaquim Batista F, Ana Maria Bispo de Filippis
Zika virus (ZIKV) has infected thousands of Brazilian people and spread to other American countries since 2015. The introduction of ZIKV brought a strong impact to public health in Brazil. It is of utmost importance to identify a susceptible cell line that will enable the isolation and identification of the virus from patient samples, viral mass production, and testing of drug and vaccine candidates. Besides real-time reverse transcriptase polymerase chain reaction diagnosis for detecting the viral genome, virus isolation in cell lines was useful in order to study the structure of the viral particle and its behaviour inside cells...
August 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27555485/optimal-cervical-screw-insertion-angle-determined-by-means-of-computed-tomography-scans-pre-and-postoperatively
#11
Masashi Uehara, Jun Takahashi, Shota Ikegami, Hiroyuki Hashidate, Shugo Kuraishi, Masayuki Shimizu, Toshimasa Futatsugi, Hiroki Oba, Keijiro Mukaiyama, Nobuhide Ogihara, Hiroki Hirabayashi, Hiroyuki Kato
BACKGROUND CONTEXT: Cervical pedicle screw (CPS) insertion is technically demanding and carries a risk of serious neurovascular complications when screws perforate. To avoid such serious risks, we currently perform CPS insertion using a computed tomography (CT)-guided navigation system. However, there remains a low probability of screw perforation during CPS insertion that is affected by factors such as CPS insertion angle and anatomical pedicle transverse angle (PTA). PURPOSE: This study aimed to understand the perforation tendencies of CPS insertion angles in relation to anatomical PTA...
August 20, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27514512/impact-of-dengue-virus-denv-co-infection-on-clinical-manifestations-disease-severity-and-laboratory-parameters
#12
Amreeta Dhanoa, Sharifah Syed Hassan, Chin Fang Ngim, Chun Fatt Lau, Teik Seng Chan, Nur Amelia Azreen Adnan, Wilhelm Wei Han Eng, Han Ming Gan, Ganeswrie Rajasekaram
BACKGROUND: The co-circulation of 4 DENV serotypes in geographically expanding area, has resulted in increasing occurrence of DENV co-infections. However, studies assessing the clinical impact of DENV co-infections have been scarce and have involved small number of patients. This study explores the impact of DENV co-infection on clinical manifestations and laboratory parameters. METHODS: This retrospective study involved consecutive hospitalized patients with non-structural protein 1 (NS1) antigen positivity during an outbreak (Jan to April 2014)...
August 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27502418/identification-of-aacasps7-an-effector-caspase-in-aedes-albopictus
#13
Lingyan Feng, Hao Liu, Xiaomei Li, Jialu Qiao, Shengya Wang, Deyin Guo, Qingzhen Liu
Aedes albopictus mosquito is a vector of various arboviruses and is becoming a significant threat to public health due to its rapid global expansion. Several reports suggest that apoptosis could be a factor limiting arbovirus infection in mosquitoes. Thus, it is significant to identify apoptosis pathway and study the correlation between apoptosis and virus infection in mosquitoes. Apoptosis is a type of programmed cell death that plays a vital role in immunity, development, and tissue homeostasis. Caspases are a family of conserved proteases playing important roles in apoptosis...
November 15, 2016: Gene
https://www.readbyqxmd.com/read/27473649/neonatal-brachial-plexus-palsy-in-children-aged-0-to-2-5%C3%A2-years-parent-perceived-family-impact-quality-of-life-and-upper-extremity-functioning
#14
Menno van der Holst, Duco Steenbeek, Willem Pondaag, Rob G H H Nelissen, Thea P M Vliet Vlieland
BACKGROUND: To investigate whether parents perceive impact of neonatal brachial plexus palsy on family and quality of life and upper extremity functioning in children less than 2.5 years. METHODS: This cross-sectional study used the PedsQL Family Impact Module (36 items/one total/four scales/scores 0 to 100), TNO-AZL (Dutch Organisation of Applied Natural Science and Academic Hospital Leiden) Preschool Children Quality of Life (43 items/12 scales/scores 0 to 100) and 21 upper extremity functioning questions...
September 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27421277/long-term-survival-case-of-malignant-glomus-tumor-mimicking-dumbbell-shaped-neurogenic-tumor
#15
Keiji Nagata, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida
PURPOSE: We report a very rare case of long-term survival case of malignant glomus tumor (MGT) without widespread metastasis. STUDY PARTICIPANTS: Sixty-three-year-old woman who experienced multiple relapses over a 40-year period beginning with a scapular lesion since she was at age 21. RESULTS: After four local recurrences, the patient underwent wide resection of the scapula at age 36. Thirteen years later, the patient had a neck tumor at the same side with the scapulectomy...
July 15, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27412733/high-performance-blue-oleds-based-on-phenanthroimidazole-emitters-via-substitutions-at-the-c6-and-c9-positions-for-improving-exciton-utilization
#16
Bin Liu, Yi Yuan, Dan He, De-Yue Huang, Cheng-Yuan Luo, Ze-Lin Zhu, Feng Lu, Qing-Xiao Tong, Chun-Sing Lee
Donor-acceptor (D-A) molecular architecture has been shown to be an effective strategy for obtaining high-performance electroluminescent materials. In this work, two D-A molecules, Ph-BPA-BPI and Py-BPA-BPI, have been synthesized by attaching highly fluorescent phenanthrene or pyrene groups to the C6- and C9-positions of a locally excited-state emitting phenylamine-phenanthroimidazole moiety. Equipped with good physical and hybridized local and charge-transfer properties, both molecules show high performances as blue emitters in nondoped organic light-emitting devices (OLEDs)...
August 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27409841/ultrastructure-of-zika-virus-particles-in-cell-cultures
#17
Debora Ferreira Barreto-Vieira, Ortrud Monika Barth, Marcos Alexandre Nunes da Silva, Carolina Cardoso Santos, Aline da Silva Santos, Joaquim Batista F, Ana Maria Bispo de Filippis
Zika virus (ZIKV) has infected thousands of Brazilian people and spread to other American countries since 2015. The introduction of ZIKV brought a strong impact to public health in Brazil. It is of utmost importance to identify a susceptible cell line that will enable the isolation and identification of the virus from patient samples, viral mass production, and testing of drug and vaccine candidates. Besides real-time reverse transcriptase polymerase chain reaction diagnosis for detecting the viral genome, virus isolation in cell lines was useful in order to study the structure of the viral particle and its behaviour inside cells...
July 11, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27383161/relationship-between-the-size-of-magnetic-nanoparticles-and-efficiency-of-mrt-imaging-of-cerebral-glioma-in-rats
#18
A S Semkina, M A Abakumov, A M Abakumov, N V Nukolova, V P Chekhonin
BSA-coated Fe3O4 nanoparticles with different hydrodynamic diameters (36±4 and 85±10 nm) were synthesized, zeta potential and T2 relaxivity were determined, and their morphology was studied by transmission electron microscopy. Studies on rats with experimental glioma C6 showed that smaller nanoparticles more effectively accumulated in the tumor and circulated longer in brain vessels. Optimization of the hydrodynamic diameter improves the efficiency of MRT contrast agent.
June 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27362576/long-term-results-of-the-monocusp-valve-formation-in-the-common-femoral-vein-in-patients-presenting-with-avalvular-deep-veins-of-the-lower-extremities
#19
Igor M Ignatyev, Rustem V Akhmetzyanov
BACKGROUND: Aim of the study was to evaluate the long-term results of the monocusp valve formation in the common femoral vein (CFV) in patients presenting with avalvular deep veins (ADV) of the lower extremities. METHODS: A total of 36 patients (24 women and 12 men) at the age varying from 37 to 58 years old were given surgical treatment during the period from 2008 to 2014. 6 patients presented with congenital ADV while in the remaining 30 ADV was a consequence of the postthrombotic lesion in the valves with the complete recanalization and manifested deep venous axial reflux...
June 30, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27351972/the-strica-homolog-aacasps16-is-involved-in-apoptosis-in-the-yellow-fever-vector-aedes-albopictus
#20
Kun Meng, Xiaomei Li, Shengya Wang, Chunyan Zhong, Zhouning Yang, Lingyan Feng, Qingzhen Liu
Caspases are a family of cysteine proteases playing essential roles during apoptosis. Seven caspases identified in Drosophila were Dronc, Dredd, Strica, Dcp-1, Decay, Drice and Damm. Among them, Strica is an insect-specific caspase containing a long serine- and threonine- rich prodomain, of which function is not yet well studied. Here we identified a homolog of strica from Aedes albopictus, named as Aacasps16. Aacasps16 encoded a protein containing a putative serine- and threonine-rich prodomain and a well conserved caspase catalytic domain...
2016: PloS One
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