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https://www.readbyqxmd.com/read/29220773/climate-change-and-dengue-fever-transmission-in-china-evidences-and-challenges
#1
REVIEW
Chenlu Li, Yongmei Lu, Jianing Liu, Xiaoxu Wu
Dengue Fever (DF) has become one of the most serious infectious diseases in China. Dengue virus and its vector (Aedes mosquito) are known to be sensitive to climate condition. Climate impacts DF through affecting three essential bioecological aspects: DF virus, vector (mosquito) and DF transmission environment. Weather-based DF model, mosquito model and climate model are the three pillars to help the prediction of DF distribution. Through a systematic review of literature between 1980 and 2017, this paper summarizes empirical evidences in China on the impact of climate change on DF; it further reviews the related DF incidence models and their findings on how changes in weather factors may impact DF occurrences in China...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220459/isoplot-a-database-for-comparison-of-mrna-isoforms-in-fruit-fly-and-mosquitoes
#2
I-Man Ng, Jia-Hsin Huang, Shang-Chi Tsai, Huai-Kuang Tsai
http://isoplot.iis.sinica.edu.tw/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29217791/full-length-genome-sequence-of-a-chikungunya-virus-isolate-from-the-2017-autochthonous-outbreak-lazio-region-italy
#3
Fabrizio Carletti, Patrizia Marsella, Francesca Colavita, Silvia Meschi, Eleonora Lalle, Licia Bordi, Domenico Di Lallo, Vincenzo Panella, Antonino Di Caro, Emanuele Nicastri, Paola Scognamiglio, Simone Lanini, Francesco Vairo, Maria R Capobianchi, Giuseppe Ippolito, Concetta Castilletti
We report here the genome sequence of a human chikungunya virus isolate from the ongoing autochthonous outbreak in central Italy. The sequence (East-Central-South African lineage, Indian Ocean sublineage), which is similar to recent sequences from Pakistan and India, shows E1 and E2 signatures of strains whose main mosquito vector is Aedes aegypti, although Aedes albopictus is the vector in Italy.
December 7, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29217460/tissue-specific-cellular-immune-responses-to-malaria-pre-erythrocytic-stages
#4
REVIEW
Olivier Silvie, Rogerio Amino, Julius Clemence Hafalla
Complete and long-lasting protective immunity against malaria can be achieved through vaccination with invasive live attenuated Plasmodium sporozoites, the motile stage inoculated in the host skin during a mosquito bite. Protective immunity relies primarily on effector CD8+ T cells targeting the parasite in the liver. Understanding the tissue-specific features of the immune response is emerging as a vital requirement for understanding protective immunity. The small parasite inoculum, the scarcity of infected cells and the tolerogenic properties of the liver represent hurdles for the establishment of protective immunity in endemic areas...
December 4, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29217264/the-immune-strategies-of-mosquito-aedes-aegypti-against-microbial-infection
#5
Yan-Hong Wang, Meng-Meng Chang, Xue-Li Wang, Ai-Hua Zheng, Zhen Zou
Yellow fever mosquito Aedes aegypti transmits many devastating arthropod-borne viruses (arboviruses), such as dengue virus, yellow fever virus, Chikungunya virus, and Zika virus, which cause great concern to human health. Mosquito control is an effective method to block the spread of infectious diseases. Ae. aegypti uses its innate immune system to fight against arboviruses, parasites, and fungi. In this review, we briefly summarize the recent findings in the immune response of Ae. aegypti against arboviral and entomopathogenic infections...
December 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29216466/the-spatiotemporal-transmission-of-dengue-and-its-driving-mechanism-a-case-study-on-the-2014-dengue-outbreak-in-guangdong-china
#6
Guanghu Zhu, Jianpeng Xiao, Bing Zhang, Tao Liu, Hualiang Lin, Xing Li, Tie Song, Yonghui Zhang, Wenjun Ma, Yuantao Hao
Dengue transmission is a complex spatiotemporal process with hidden interactions between hosts, vectors, and viruses as well as environment. This study aims to identify the transmission patterns and the driving mechanism that contributed to the dengue epidemics occurred in Guangdong Province of China in 2014. Based on the city-specific epidemiological, meteorological, demographic and geographic data, we first performed wavelet analysis and then integrated the key dynamics (i.e., mosquito population dynamics, human movement, virus transmission, and parameter estimation) into a transmission model...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216395/a-randomized-trial-of-the-prophylactic-activity-of-dsm265-against-pre-erythrocytic-plasmodium-falciparum-controlled-human-malaria-infection-by-mosquito-bites-and-direct-venous-inoculation
#7
Sean C Murphy, Elizabeth R Duke, Kelly J Shipman, Ryan L Jensen, Youyi Fong, Sue Ferguson, Holly E Janes, Kevin Gillespie, Annette M Seilie, Amelia E Hanron, Laurie Rinn, Matthew Fishbaugher, Tracie VonGoedert, Emma Fritzen, Stefan H Kappe, Ming Chang, Jason C Sousa, Sean R Marcsisin, Stephan Chalon, Stephan Duparc, Nicola Kerr, Jörg J Möhrle, Nicole Andenmatten, Thomas Rueckle, James G Kublin
Background: DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered one day pre-challenge and provided partial protection when administered seven days pre-challenge. Methods: A double-blind, randomized, placebo-controlled trial was performed to assess safety, tolerability, pharmacokinetics and efficacy of one oral dose of 400 mg DSM265 pre-CHMI...
December 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29216368/ross-river-virus-and-the-necessity-of-multi-scale-eco-epidemiological-analyses
#8
Emily J Flies, Philip Weinstein, Sharolyn J Anderson, Iain Koolhof, Johannes Foufopoulos, Craig R Williams
Background: Zoonotic vector-borne disease prevalence is affected by vector, human and reservoir host factors, which are influenced by habitat and climate; these five components interact on microhabitat to landscape scales but are often analyzed at a single spatial scale. Methods: We present an information theoretic, multi-scale, multiple regression analysis of the ecological drivers of Ross River virus. We analyze the spatial pattern of 20 years of Ross River virus infections from South Australia (1992-2012; n = 5,261) using variables across these five components of disease ecology at three spatial scales...
December 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29216317/novel-wolbachia-transinfected-aedes-aegypti-mosquitoes-possess-diverse-fitness-and-vector-competence-phenotypes
#9
Johanna E Fraser, Jyotika Taneja De Bruyne, Iñaki Iturbe-Ormaetxe, Justin Stepnell, Rhiannon L Burns, Heather A Flores, Scott L O'Neill
Wolbachia pipientis from Drosophila melanogaster (wMel) is an endosymbiotic bacterium that restricts transmission of human pathogenic flaviviruses and alphaviruses, including dengue, Zika, and chikungunya viruses, when introduced into the mosquito vector Aedes aegypti. To date, wMel-infected Ae. aegypti have been released in field trials in 5 countries to evaluate the effectiveness of this strategy for disease control. Despite the success in establishing wMel-infected mosquitoes in wild populations, and the well-characterized antiviral capabilities of wMel, transinfecting different or additional Wolbachia strains into Ae...
December 7, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29216248/effect-of-land-use-changes-on-the-abundance-distribution-and-host-seeking-behavior-of-aedes-arbovirus-vectors-in-oil-palm-dominated-landscapes-southeastern-c%C3%A3-te-d-ivoire
#10
Julien B Z Zahouli, Benjamin G Koudou, Pie Müller, David Malone, Yao Tano, Jürg Utzinger
BACKGROUND: Identifying priority areas for vector control is of considerable public health relevance. Arthropod-borne viruses (arboviruses) spread by Aedes mosquitoes are (re)emerging in many parts of the tropics, partially explained by changes in agricultural land-use. We explored the effects of land-use changes on the abundance, distribution, and host-seeking behavior of Aedes mosquitoes along a gradient of anthropogenic disturbance in oil palm-dominated landscapes in southeastern Côte d'Ivoire...
2017: PloS One
https://www.readbyqxmd.com/read/29215274/cry11aa-interacts-with-the-atp-binding-protein-from-culex-quinquefasciatus-to-improve-the-toxicity
#11
Lingling Zhang, Guohui Zhao, Xiaohua Hu, Jiannan Liu, Mingwei Li, Khadija Batool, Mingfeng Chen, Junxiang Wang, Jin Xu, Tianpei Huang, Xiaohong Pan, Lei Xu, Xiao-Qiang Yu, Xiong Guan
Cry11Aa displays high toxicity to the larvae of several mosquito species, including Aedes, Culex, and Anopheles. To study its binding characterization against Culex quinquefasciatus, Cry11Aa was purified and western blot results showed that Cry11Aa could bind successfully to the brush border membrane vesicles. To identify Cry11Aa-binding proteins in C. quinquefasciatus, a biotin-based protein pull-down experiment was performed and seven Cry11Aa-binding proteins were isolated from the midgut of C. quinquefasciatus larvae...
December 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29213208/awareness-of-malaria-and-treatment-seeking-behaviour-among-persons-with-acute-undifferentiated-fever-in-the-endemic-regions-of-myanmar
#12
Phyo Aung Naing, Thae Maung Maung, Jaya Prasad Tripathy, Tin Oo, Khin Thet Wai, Aung Thi
Background: Myanmar has a high burden of malaria with two-third of the population at risk of malaria. One of the basic elements of the Roll Back Malaria Initiative to fight against malaria is early diagnosis and treatment within 24 h of fever. Public awareness about malaria is a key factor in malaria prevention and control and in improving treatment-seeking behaviour. Methods: A large community-based survey was carried out in 27 townships of malaria endemic regions in Myanmar in 2015 which reported on the knowledge, behaviour and practices around malaria in the general population...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29212553/household-knowledge-and-practices-concerning-malaria-and-indoor-residual-spraying-in-an-endemic-area-earmarked-for-malaria-elimination-in-iran
#13
Abdoulhossain Madani, Moussa Soleimani-Ahmadi, Sayed Hossein Davoodi, Alireza Sanei-Dehkordi, Seyed Aghil Jaberhashemi, Mehdi Zare, Teamur Aghamolaei
BACKGROUND: Indoor residual spraying of insecticide (IRS) is a key intervention for reducing the burden of malaria infection. Effectiveness and success of this strategy are to a considerable extent dependent on knowledge and practice of the target community regarding the IRS. Iran has entered the malaria elimination phase, and IRS has been considered as the main strategy for malaria vector control. Therefore, this study was conducted to determine the household knowledge and practices about malaria and IRS in Bashagard County, one of the malaria-endemic areas in the southeast of Iran...
December 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29211830/antibiotic-utilization-and-the-role-of-suspected-and-diagnosed-mosquito-borne-illness-among-adults-and-children-with-acute-febrile-illness-in-pune-india
#14
Matthew Robinson, Dileep Kadam, Anju Kagal, Sandhya Khadse, Aarti Kinikar, Chhaya Valvi, Anita Basavaraj, Renu Bharadwaj, Ivan Marbaniang, Savita Kanade, Priyanka Raichur, Jonathan Sachs, Eili Klein, Sara Cosgrove, Amita Gupta, Vidya Mave
Background: Antibiotic resistance mechanisms originating in low- and middle- income countries are among the most common worldwide. Reducing unnecessary antibiotic use in India, the world's largest antibiotic consumer is crucial to control antimicrobial resistance globally. Limited data describing factors influencing Indian clinicians to start or stop antibiotics is available. Methods: Febrile adults and children admitted to a public tertiary care hospital in Pune, India were enrolled...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29211244/dengue-serotype-specific-immune-response-in-aedes-aegypti-and-aedes-albopictus
#15
Chelsea T Smartt, Dongyoung Shin, Barry W Alto
BACKGROUND: Dengue viruses (DENV) are considered one of the most important emerging pathogens and dengue disease is a global health threat. The geographic expansion of dengue viruses has led to co-circulation of all four dengue serotypes making it imperative that new DENV control strategies be devised. OBJECTIVES: Here we characterize dengue serotype-specific innate immune responses in Aedes aegypti and Aedes albopictus using DENV from Puerto Rico (PR). METHODS: Ae...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29211239/urban-malaria-transmission-in-a-non-endemic-area-in-the-andean-region-of-colombia
#16
Pablo E Chaparro, Karen Molina, Alberto Alzate, Julio Padilla, Myriam Arévalo-Herrera, Sócrates Herrera
BACKGROUND: Rapid urbanisation in difficult socio-economic conditions such as inadequate housing infrastructure, lack of public services, improper sanitation, and poor water drainage systems in vegetation-rich areas lead to ecological conditions that are conducive to the breeding of mosquitoes and transmission of malaria, in semi-urban and urban settings. OBJECTIVES: This study aimed to describe the cases of malaria that were reported in the peri-urban areas of Pereira (Colombia), between 2008 and 2015...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29206076/assessment-of-the-ability-of-v920-recombinant-vesicular-stomatitis-zaire-ebolavirus-vaccine-to-replicate-in-relevant-arthropod-cell-cultures-and-vector-species
#17
Nicholas A Bergren, Megan R Miller, Thomas P Monath, Rebekah C Kading
V920, rVSVΔG-ZEBOV-GP, is a recombinant vesicular stomatitis-Zaire ebolavirus vaccine which has shown an acceptable safety profile and provides a protective immune response against Ebola virus disease (EVD) induced by Zaire ebolavirus in humans. The purpose of this study was to determine whether the V920 vaccine is capable of replicating in arthropod cell cultures of relevant vector species and of replicating in live mosquitoes. While the V920 vaccine replicated well in Vero cells, no replication was observed in Anopheles or Aedes mosquito, Culicoides biting midge, or Lutzomyia sand fly cells, nor in live Culex or Aedes mosquitoes following exposure through intrathoracic inoculation or feeding on a high-titer infectious blood meal...
December 5, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29205153/an-aedes-aegypti-associated-fungus-increases-susceptibility-to-dengue-virus-by-modulating-gut-trypsin-activity
#18
Yesseinia I Angleró-Rodríguez, Octavio Ac Talyuli, Benjamin J Blumberg, Seokyoung Kang, Celia Demby, Alicia Shields, Jenny Carlson, Natapong Jupatanakul, George Dimopoulos
Transmission of dengue virus (DENV) requires successful completion of the infection cycle in the Aedes aegypti vector, which is initiated in the midgut tissue after ingestion of an infectious blood meal. While certain Ae. aegypti midgut-associated bacteria influence virus infection, little is known about the midgut-associated fungi (mycobiota), and how its members might influence susceptibility to DENV infection. We show that a Talaromyces (Tsp_PR) fungus, isolated from field-caught Ae. aegypti, render the mosquito more permissive to DENV infection...
December 5, 2017: ELife
https://www.readbyqxmd.com/read/29202041/global-transcriptome-analysis-of-aedes-aegypti-mosquitoes-in-response-to-zika-virus-infection
#19
Kayvan Etebari, Shivanand Hegde, Miguel A Saldaña, Steven G Widen, Thomas G Wood, Sassan Asgari, Grant L Hughes
Zika virus (ZIKV) of the Flaviviridae family is a recently emerged mosquito-borne virus that has been implicated in the surge of the number of microcephaly instances in South America. The recent rapid spread of the virus led to its declaration as a global health emergency by the World Health Organization. The virus is transmitted mainly by the mosquito Aedes aegypti, which is also the vector of dengue virus; however, little is known about the interactions of the virus with the mosquito vector. In this study, we investigated the transcriptome profiles of whole A...
November 2017: MSphere
https://www.readbyqxmd.com/read/29198600/heterogeneous-distribution-of-culex-pipiens-culex-quinquefasciatus-and-their-hybrids-along-the-urbanisation-gradient
#20
M V Cardo, A Rubio, M T Junges, D Vezzani, A E Carbajo
2 The mosquitoes of the Culex pipiens complex, hereafter referred to as the Pipiens Assemblage, are vectors of arbovirus of worldwide concern including West Nile and St. Louis encephalitis. Given their distinct eco-physiology and vectorial capacity, accurate specimen identification and insight in the environmental drivers of their distribution are essential for the understanding of disease transmission patterns. Using a PCR-based identification protocol, we characterized the spatial distribution of Cx. pipiens, Cx...
November 30, 2017: Acta Tropica
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