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https://www.readbyqxmd.com/read/28433681/n-aryl-n-ethyleneaminothioureas-effectively-inhibit-acetylcholinesterase-1-from-disease-transmitting-mosquitoes
#1
Sofie Knutsson, Tomas Kindahl, Cecilia Engdahl, Dariush Nikjoo, Nina Forsgren, Stanley Kitur, Fredrik Ekström, Luna Kamau, Anna Linusson
Vector control of disease-transmitting mosquitoes by insecticides has a central role in reducing the number of parasitic- and viral infection cases. The currently used insecticides are efficient, but safety concerns and the development of insecticide-resistant mosquito strains warrant the search for alternative compound classes for vector control. Here, we have designed and synthesized thiourea-based compounds as non-covalent inhibitors of acetylcholinesterase 1 (AChE1) from the mosquitoes Anopheles gambiae (An...
March 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28433568/the-role-of-copulatory-plugs-in-the-mosquito-parasitic-nematode-strelkovimermis-spiculatus
#2
Yu-Han Lan, Yi Wang, Randy Gaugler
The mosquito-parasitic nematode, Strelkovimermis spiculatus (Mermithidae: Nematoda) emerges from hosts and aggregates to form mating clusters characterized by intense male-male competition for females. Successful males deposit an adhesive copulatory plug over the female vulva after insemination. In choice experiments, males strongly preferred virgin females, whereas plugged females were ignored. Males made no attempt to displace copulatory plugs deposited by previous males. Plugged females repelled males without the need for physical contact...
April 19, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28433051/insect-specific-viruses-a-historical-overview-and-recent-developments
#3
Christopher M Roundy, Sasha R Azar, Shannan L Rossi, Scott C Weaver, Nikos Vasilakis
Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28432859/the-impact-of-global-climate-change-on-the-spread-of-parasitic-nematodes
#4
Anna Okulewicz
Climate changes may influence the frequency, intensity and geographical distribution of parasites, directly affecting their dispersive stages in the environment (eggs, larvae) and, indirectly, the larvae living mainly in invertebrate intermediate hosts. In biologically diverse nematodes climate warming contributes to the increase in the range of distribution, colonization of new hosts and modification of their development cycles. This is particularly acute in the Arctic and pertains, for instance, to nematodes Ostertagia gruehneri and Setaria tundra parasitizing reindeer Rangifer tarandus and Umingmakstrongylus pallikuukensis in musk oxen (Ovibos moschatus)...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28432154/identification-of-the-septate-junction-protein-gliotactin-in-the-mosquito-aedes-aegypti-evidence-for-a-role-in-increased-paracellular-permeability-in-larvae
#5
Sima Jonusaite, Scott P Kelly, Andrew Donini
Septate junctions (SJs) regulate paracellular permeability across invertebrate epithelia. However, little is known about the function of SJ proteins in aquatic invertebrates. In this study, a role for the transmembrane SJ protein gliotactin (Gli) in the osmoregulatory strategies of larval mosquito (Aedes aegypti) was examined. Differences in gli transcript abundance were observed between the midgut, Malpighian tubules (MT), hindgut and anal papillae (AP) of A. aegypti, which are epithelia that participate in larval mosquito osmoregulation...
April 21, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28431895/hemolymph-proteins-of-anopheles-gambiae-larvae-infected-by-escherichia-coli
#6
Xuesong He, Xiaolong Cao, Yan He, Krishna Bhattarai, Janet Rogers, Steve Hartson, Haobo Jiang
Anopheles gambiae is a major vector of human malaria and its immune system in part determines the fate of ingested parasites. Proteins, hemocytes and fat body in hemolymph are critical components of this system, mediating both humoral and cellular defenses. Here we assessed differences in the hemolymph proteomes of water- and E. coli-pricked mosquito larvae by a gel-LC-MS approach. Among the 1756 proteins identified, 603 contained a signal peptide but accounted for two-third of the total protein amount on the quantitative basis...
April 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28431880/photo-controlled-release-of-fipronil-from-a-coumarin-triggered-precursor
#7
Zhenhong Gao, Pengtao Yuan, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao
Developing efficient controlled release system of insecticide can facilitate the better use of insecticide. We described here a first example of photo-controlled release of an insecticide by linking fipronil with photoresponsive coumarin covalently. The generated coumarin-fipronil (CF) precursor could undergo cleavage to release free fipronil in the presence of blue light (420nm) or sunlight. Photophysical studies of CF showed that it exhibited strong fluorescence properties. The CF had no obvious activity against mosquito larvae under dark, but it can be activated by light inside the mosquito larvae...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28431639/advances-in-molecular-diagnosis-of-malaria
#8
Zhi Zheng, Zhibin Cheng
Malaria is a mosquito-borne disease caused by five species of Plasmodium parasites. Accurate diagnosis of malaria plays an essential part in malaria control. With traditional diagnostic methodologies, malaria control programs have achieved remarkable success during the past decade, and are now heading toward malaria elimination in many areas. This new situation, however, calls for novel diagnostics with improved sensitivity, throughput, and reduced cost for active screening of malaria parasites, as all transfected individuals have to be identified in order to block transmission...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28431281/dengue-virus-replicates-and-accumulates-in-aedes-aegypti-salivary-glands
#9
Vincent Raquin, Louis Lambrechts
Dengue virus (DENV) is an RNA virus transmitted among humans by mosquito vectors, mainly Aedes aegypti. DENV transmission requires viral dissemination from the mosquito midgut to the salivary glands. During this process the virus undergoes several population bottlenecks, which are stochastic reductions in population size that restrict intra-host viral genetic diversity and limit the efficiency of natural selection. Despite the implications for virus transmission and evolution, DENV replication in salivary glands has not been directly demonstrated...
April 18, 2017: Virology
https://www.readbyqxmd.com/read/28431166/landscape-genetics-of-aedes-mcintoshi-diptera-culicidae-an-important-vector-of-rift-valley-fever-virus-in-northeastern-kenya
#10
Lindsay P Campbell, Alana M Alexander
Rift Valley fever virus (RVFV) is a vector-borne, zoonotic disease that affects humans, wild ungulates, and domesticated livestock in Africa and the Arabian Peninsula. Rift Valley fever virus exhibits interepizootic and epizootic phases, the latter defined by widespread virus occurrence in domesticated livestock. Kenya appears to be particularly vulnerable to epizootics, with 11 outbreaks occurring between 1951 and 2007. The mosquito species Aedes mcintoshi (subgenus Neomelaniconion) is an important primary vector for RVFV in Kenya...
April 18, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28430778/a-no-film-slot-blot-for-the-detection-of-developing-p-falciparum-oocysts-in-mosquitoes
#11
Bryan Grabias, Nitin Verma, Hong Zheng, Abhai K Tripathi, Godfree Mlambo, Merribeth J Morin, Emily Locke, Sanjai Kumar
Non-microscopy-based assays for sensitive and rapid detection of Plasmodium infection in mosquitoes are needed to allow rapid and high throughput measurement of transmission intensity and malaria control program effectiveness. Here, we report on a modified enhanced chemiluminescence-based slot blot assay for detection of Plasmodium falciparum (Pf) circumsporozite protein (PfCSP) expressed on parasite oocysts developing inside the mosquito midgut. This modified assay has several novel features that include eliminating the need for exposure to autoradiography (AR) film, as well as utilizing a novel high affinity anti-CSP antibody, and optimizing assay procedures resulting in significant reduction in the time required to perform the assay...
2017: PloS One
https://www.readbyqxmd.com/read/28430564/effects-of-zika-virus-strain-and-aedes-mosquito-species-on-vector-competence
#12
Alexander T Ciota, Sean M Bialosuknia, Steven D Zink, Matthew Brecher, Dylan J Ehrbar, Madeline N Morrissette, Laura D Kramer
In the Western Hemisphere, Zika virus is thought to be transmitted primarily by Aedes aegypti mosquitoes. To determine the extent to which Ae. albopictus mosquitoes from the United States are capable of transmitting Zika virus and the influence of virus dose, virus strain, and mosquito species on vector competence, we evaluated multiple doses of representative Zika virus strains in Ae. aegypti and Ae. albopictus mosquitoes. Virus preparation (fresh vs. frozen) significantly affected virus infectivity in mosquitoes...
July 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28430562/competence-of-aedes-aegypti-ae-albopictus-and-culex-quinquefasciatus-mosquitoes-as-zika-virus-vectors-china
#13
Zhuanzhuan Liu, Tengfei Zhou, Zetian Lai, Zhenhong Zhang, Zhirong Jia, Guofa Zhou, Tricia Williams, Jiabao Xu, Jinbao Gu, Xiaohong Zhou, Lifeng Lin, Guiyun Yan, Xiao-Guang Chen
In China, the prevention and control of Zika virus disease has been a public health threat since the first imported case was reported in February 2016. To determine the vector competence of potential vector mosquito species, we experimentally infected Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus mosquitoes and determined infection rates, dissemination rates, and transmission rates. We found the highest vector competence for the imported Zika virus in Ae. aegypti mosquitoes, some susceptibility of Ae...
July 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28430103/genomic-characterization-of-recrudescent-plasmodium-malariae-after-treatment-with-artemether-lumefantrine
#14
Gavin G Rutledge, Ian Marr, G Khai Lin Huang, Sarah Auburn, Jutta Marfurt, Mandy Sanders, Nicholas J White, Matthew Berriman, Chris I Newbold, Nicholas M Anstey, Thomas D Otto, Ric N Price
Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. By using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. Haplotypic analysis of the clones in the initial infection revealed that they were all closely related and were presumably recombinant progeny originating from the same infective mosquito bite...
August 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28429288/zika-virus-a-novel-mosquito-borne-congenital-virus-infection
#15
EDITORIAL
J David Beckham
No abstract text is available yet for this article.
April 20, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28429036/a-review-of-zika-virus-infections-in-pregnancy-and-implications-for-antenatal-care-in-singapore
#16
Harvard Zhenjia Lin, Paul Anantharajah Tambyah, Eu Leong Yong, Arijit Biswas, Shiao-Yng Chan
Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28428935/genetic-analysis-of-mosquito-detection-of-humans
#17
Joshua I Raji, Matthew DeGennaro
Mosquitoes detect the presence of humans by integrating chemosensory, thermal, and visual cues. Among these, odors are crucial for mosquito host detection. Insects have evolved a diverse repertoire of receptors to detect their plant and animal hosts. Genetic analysis of these receptors in Drosophila has set the stage for similar studies in mosquitoes. The diversity of the cues involved in mosquito host-seeking has made designing behavioral control strategies a challenge. The sensory receptors that are most important for mosquito detection of humans can now be determined using genome editing...
April 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28427450/presence-of-susceptible-wild-strains-of-anopheles-gambiae-in-a-large-industrial-palm-farm-located-in-aboisso-south-eastern-of-c%C3%A3-te-d-ivoire
#18
Cécile M A Sadia-Kacou, Ludovic P Ahoua Alou, Ako V C Edi, Celine M Yobo, Maurice A Adja, Allassane F Ouattara, David Malone, Alphonsine A Koffi, Yao Tano, Benjamin G Koudou
BACKGROUND: The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d'Ivoire, where palm oil plantations remain the predominant agricultural crop, the susceptibility of wild Anopheles gambiae sensu lato species is still unknown and thus requires a particular attention. The current study was carried out to address the gap by in-depth characterization of susceptibility level of An...
April 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28427447/benchmarking-insecticide-resistance-intensity-bioassays-for-anopheles-malaria-vector-species-against-resistance-phenotypes-of-known-epidemiological-significance
#19
Nelius Venter, Shȕné V Oliver, Mbanga Muleba, Craig Davies, Richard H Hunt, Lizette L Koekemoer, Maureen Coetzee, Basil D Brooke
BACKGROUND: Insecticide use via indoor residual spraying (IRS) or treated nets is the primary method for controlling malaria vector populations. The incidence of insecticide resistance in vector populations is burgeoning globally making resistance management key to the design of effective malaria control and elimination strategies. Vector populations can be assessed for insecticide resistance using a binary (susceptible or resistant) classification based on the use of the standard WHO insecticide susceptibility assay for adult anopheline mosquitoes...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28427437/efficacy-and-user-acceptability-of-transfluthrin-treated-sisal-and-hessian-decorations-for-protecting-against-mosquito-bites-in-outdoor-bars
#20
John P Masalu, Marceline Finda, Fredros O Okumu, Elihaika G Minja, Arnold S Mmbando, Maggy T Sikulu-Lord, Sheila B Ogoma
BACKGROUND: A number of mosquito vectors bite and rest outdoors, which contributes to sustained residual malaria transmission in endemic areas. Spatial repellents are thought to create a protective "bubble" within which mosquito bites are reduced and may be ideal for outdoor use. This study builds on previous studies that proved efficacy of transfluthrin-treated hessian strips against outdoor biting mosquitoes. The goal of this study was to modify strips into practical, attractive and acceptable transfluthrin treated sisal and hessian emanators that confer protection against potential infectious bites before people use bed nets especially in the early evening and outdoors...
April 20, 2017: Parasites & Vectors
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