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https://www.readbyqxmd.com/read/27619776/early-identification-of-dpam-in-at-risk-low-grade-appendiceal-mucinous-neoplasm-patients-a-new-approach-to-surveillance-for-peritoneal-metastasis
#1
Jason M Foster, Richard L Sleightholm, Steve Wahlmeier, Brian Loggie, Poonam Sharma, Asish Patel
BACKGROUND: Disseminated peritoneal adenomucinosis (DPAM) patients often have a history of appendectomy with identification of an incidental mucinous neoplasm (low-grade appendiceal mucinous neoplasm (LAMN)). The rate of developing DPAM is not well established. METHODS: Twenty-two patients with incidental LAMN were identified and monitored with cancer markers and CT every 4-6 months. Laparoscopy with peritoneal washing was performed in patients either in the event of radiographic disease or after 12 months in absence of radiographic disease...
September 13, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27121698/significance-of-epithelial-cell-clusters-in-pseudomyxoma-peritonei
#2
R K Badyal, A Khairwa, A Rajwanshi, R Nijhawan, S Radhika, N Gupta, P Dey
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterised by distension of the peritoneum by jelly-like ascites. Cytological evaluation of peritoneal fluid is often an initial diagnostic test for possible ovarian and/or appendiceal primary tumours. AIMS AND OBJECTIVES: The present work was conducted to study the usefulness of peritoneal fluid cytomorphology in the early diagnosis of PMP and to evaluate the significance of the presence of epithelial cell (EC) clusters and their prognostic implications...
April 28, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/26838886/interaction-of-dinuclear-cadmium-ii-5-cl-salicylaldehyde-complexes-with-calf-thymus-dna
#3
Maja Sumar Ristovic, Ariadni Zianna, George Psomas, Antonios G Hatzidimitriou, Evdoxia Coutouli-Argyropoulou, Maria Lalia-Kantouri
Five dinuclear Cd(II) complexes with the anion of 5-Cl-salicylaldehyde (5-Cl-saloH) were synthesized in the absence or presence of the α-diimines: 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (neoc) or 2,2'-dipyridylamine (dpamH) and characterized as [Cd(5-Cl-salo)2(CH3OH)]2 (1), [Cd(5-Cl-salo)2(bipy)]2 (2), [Cd(5-Cl-salo)2(phen)]2 (3), [Cd(5-Cl-salo)(neoc)(ONO2)]2 (4) and [Cd(5-Cl-salo)(dpamΗ)(ONO2)]2 (5). The complexes were characterized by spectroscopic techniques (IR, UV-vis, (1)H-NMR and (13)C-NMR), elemental analysis and molar conductivity measurements...
April 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26714951/the-7th-edition-of-the-ajcc-staging-classification-correlates-with-biologic-behavior-of-mucinous-appendiceal-tumor-with-peritoneal-metastases-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#4
Vladimir Milovanov, Armando Sardi, Kimberley Studeman, Carol Nieroda, Michelle Sittig, Vadim Gushchin
PURPOSE: We evaluated the 7th edition of the American Joint Committee on Cancer (AJCC) staging classification in terms of overall survival (OS) in patients with PMP treated with cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: A total of 208 PMP patients treated with CRS/HIPEC were identified from a prospective database. Patients with peritoneal mucinous carcinomatosis (PMCA) were retrospectively staged at time of diagnosis according to AJCC staging classification...
June 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26475379/molecular-profiles-of-high-grade-and-low-grade-pseudomyxoma-peritonei
#5
Rei Noguchi, Hideaki Yano, Yoshimasa Gohda, Ryuichiro Suda, Toru Igari, Yasunori Ohta, Naohide Yamashita, Kiyoshi Yamaguchi, Yumi Terakado, Tsuneo Ikenoue, Yoichi Furukawa
Pseudomyxoma peritonei (PMP) is a rare disease exhibiting a distinct clinical feature caused by cancerous cells that produce mucinous fluid in the abdominal cavity. PMPs originate most frequently from the appendix and less frequently from the ovary. This disease can range from benign to malignant, and histologically, PMP is classified into two types: disseminated peritoneal adenomucinosis (DPAM) representing the milder phenotype, and peritoneal mucinous adenocarcinomas (PMCA) representing the aggressive phenotype...
December 2015: Cancer Medicine
https://www.readbyqxmd.com/read/26179296/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-long-term-results-at-st-george-hospital-australia
#6
Nayef Alzahrani, Jorgen S Ferguson, Sarah J Valle, Winston Liauw, Terence Chua, David L Morris
BACKGROUND: Peritoneal carcinomatosis (PC) results from the secondary spread of many intraabdominal tumour types, such as colorectal malignancy (colorectal cancer, CRC), disseminated peritoneal adenomucinosis (DPAM), appendiceal cancer, ovarian carcinoma, sarcoma or from the occurrence of primary peritoneal disease such as peritoneal mesothelioma. The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has seen improvements in survival in selected cases of these cancers...
November 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/25602214/granular-and-dissolved-polyacrylamide-effects-on-erosion-and-runoff-under-simulated-rainfall
#7
Jihoon Kang, Aziz Amoozegar, Joshua L Heitman, Richard A McLaughlin
Polyacrylamide (PAM) has been demonstrated to reduce erosion under many conditions, but less is known about the effects of its application method on erosion and concentrations in the runoff water. A rainfall simulation study was conducted to evaluate the performance of an excelsior erosion control blanket (cover) and two PAM application methods. The treatments were (i) no cover + no PAM (control), (ii) cover + no PAM, (iii) cover + granular PAM (GPAM), and (iv) cover + dissolved PAM (DPAM) applied to soil packed in wooden runoff boxes...
November 2014: Journal of Environmental Quality
https://www.readbyqxmd.com/read/25100893/progression-of-peritoneal-adenomucinosis-to-the-scrotum-a-rare-occurrence-treated-with-cytoreductive-surgery-and-hyperthermic-chemoperfusion-of-the-scrotum-in-two-patients
#8
Armando Sardi, William Andrés Jiménez, Chukwuemeka Wosu
INTRODUCTION: Disseminated Peritoneal Adenomucinosis (DPAM) is an infrequent presentation of appendiceal cancer. Infrequently, umbilical or inguinal hernias could be the first clinical manifestation of this condition; DPAM extension to the scrotum may be anatomically viable. Treatment with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the standard of treatment for DPAM. We hypothesize that these same treatment principles, consisting of CRS with hyperthermic chemoperfusion of the scrotum (HCS), could be applied to the scrotal dissemination of DPAM...
April 2014: Colombia Médica: CM
https://www.readbyqxmd.com/read/24986239/predictive-and-prognostic-survival-factors-in-peritoneal-carcinomatosis-from-appendiceal-cancer-after-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#9
William Jimenez, Armando Sardi, Carol Nieroda, Michelle Sittig, Vladimir Milovanov, Maria Nunez, Nail Aydin, Vadim Gushchin
BACKGROUND: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has survival benefit in the treatment of selected patients with peritoneal carcinomatosis (PC) from appendiceal cancer (AC). We evaluated factors affecting the survival of patients with PC from AC after CRS/HIPEC. METHODS: A retrospective analysis of 387 CRS/HIPEC procedures performed between February 1998 and February 2013 identified 202 patients with PC from AC. Tumor histopathology, complete cytoreduction (CC 0-1), Peritoneal Cancer Index (PCI), and lymph node (LN) status were related to overall survival (OS) and progression-free survival (PFS) using the Kaplan-Meier method...
December 2014: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/24750186/prognostic-significance-of-single-isolated-cells-with-decreased-e-cadherin-expression-in-pseudomyxoma-peritonei
#10
Young Wha Koh, Sun-Young Jun, Kyu-Rae Kim
Pseudomyxoma peritonei (PMP) cases can be classified into the prognosis-related subtypes of disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis (PMCA). To investigate the mechanisms of mucinous invasion and the differing prognoses of these two subtypes, we examined the expression levels of proteins involved in cellular adhesion and invasion, including E-cadherin, vimentin, β-catenin, and S100A4, in single isolated tumor cells (SICs) and cohesive cellular strips within mucin pools isolated from DPAM (n = 31) and PMCA (n = 21) patients...
April 2014: Pathology International
https://www.readbyqxmd.com/read/24548955/treating-pseudomyxoma-peritonei-without-heated-intraperitoneal-chemotherapy-a-first-look-in-new-zealand
#11
Benjamin R Wheeler, Sumeet K Reddy, Diane Kenwright, John P Keating
BACKGROUND: Pseudomyxoma peritonei is a condition characterised by dissemination of mucin-producing neoplastic cells throughout the peritoneal cavity. There are two pathological subsets, disseminated peritoneal adenomucinosis and peritoneal mucinosis carcinomatosis. Once a lethal disease, cytoreductive surgery combined with heated intraperitoneal chemotherapy (HIPEC) is challenging debulking as the standard of care. OBJECTIVE: We present the first case series detailing the postoperative morbidity, mortality and survival outcomes of patients treated for pseudomyxoma peritonei by cytoreductive surgery without heated intraperitoneal chemotherapy by a single surgeon...
February 14, 2014: New Zealand Medical Journal
https://www.readbyqxmd.com/read/24332046/valid-measures-of-periodic-leg-movements-plms-during-a-suggested-immobilization-test-using-the-pam-rl-leg-activity-monitors-require-adjusting-detection-parameters-for-noise-and-signal-in-each-recording
#12
Myung Sung Yang, Jacques Montplaisir, Alex Desautels, John W Winkelman, Michel A Cramer Bornemann, Christopher J Earley, Richard P Allen
OBJECTIVE AND BACKGROUND: Individuals with restless legs syndrome (RLS) (Willis-Ekbom disease [WED]) usually have periodic leg movements (PLMs). The suggested immobilization test (SIT) measures sensory and motor features of WED during wakefulness. Surface electromyogram (EMG) recordings of the anterior tibialis (AT) are used as the standard for counting PLMs. However, due to several limitations, leg activity meters such as the PAM-RL were advanced as a potential substitute. In our study, we assessed the validity of the measurements of PLM during wakefulness (PLMW) in the SIT for PAM-RL using both default and custom detection threshold parameters compared to AT EMG...
January 2014: Sleep Medicine
https://www.readbyqxmd.com/read/24199925/-prognostic-value-of-clinical-and-pathological-characteristics-in-48-women-with-pseudomyxoma-peritonei
#13
Yi-yan Lu, Ai-tao Guo, Ai-jun Liu, Huai-yin Shi
OBJECTIVE: To investigate the clinic-pathological characteristics and prognosis of 48 female cases with peritoneal pseudomyxoma(PMP). METHODS: The clinicopathologic features and follow-up data of 48 female patients with PMP diagnosed in the General Hospital of People's Liberation Army from Jan.1982 to Dec.2011 were retrospectively reviewed. The relationship between clinic-pathological characteristics and prognosis were analyzed using log-rank test and Cox proportional hazards model...
August 2013: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/24024058/pseudomyxoma-peritonei-originating-from-an-intestinal-duplication
#14
Julie Lemahieu, André D'Hoore, Stijn Deloose, Raf Sciot, Philippe Moerman
Alimentary tract duplications are rare congenital anomalies. They most often become symptomatic in childhood and rarely undergo malignant transformation. Pseudomyxoma peritonei (PMP) is an equally uncommon condition, most frequently originating from a primary appendiceal mucinous neoplasm. We report an extremely unusual case of PMP arising from an intestinal duplication. A 67-year-old woman presented with vague upper abdominal pain, and, unexpectedly, explorative laparoscopy revealed diffuse jelly-like peritoneal implants...
2013: Case Reports in Pathology
https://www.readbyqxmd.com/read/23743566/antibiotic-treatment-decreases-microbial-burden-associated-with-pseudomyxoma-peritonei-and-affects-%C3%AE-catenin-distribution
#15
Cristina Semino-Mora, Traci L Testerman, Hui Liu, Jeannette M Whitmire, Kimberley Studeman, Yali Jia, Thomas J McAvoy, Jennifer Francis, Carol Nieroda, Armando Sardi, D Scott Merrell, Andre Dubois
PURPOSE: Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and β-catenin expression within pseudomyxoma peritonei samples. EXPERIMENTAL DESIGN: The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA)...
July 15, 2013: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/23730513/carbohydrate-antigen-19-9-ca-19-9-is-an-independent-prognostic-indicator-in-pseudomyxoma-peritonei-post-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#16
Ju-Li Koh, Winston Liauw, Terence Chua, David L Morris
INTRODUCTION: Pseudomyxoma peritonei (PMP) is characteristically divided into two histopathological subtypes; disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis (PMCA). The latter is associated with a worse prognosis. However, even within the DPAM group, there is a considerable variation in outcome. In this study we investigate the role of baseline serum tumor markers CA 19-9, CEA and CA-125 in further stratifying survival. METHODS: Over 16 years, 218 patients with PMP were treated with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) at our institution...
June 2013: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/23456382/surveillance-mr-imaging-is-superior-to-serum-tumor-markers-for-detecting-early-tumor-recurrence-in-patients-with-appendiceal-cancer-treated-with-surgical-cytoreduction-and-hipec
#17
Russell N Low, Robert M Barone, Melissa J Lee
BACKGROUND: The purpose of this study was to determine if MRI surveillance is better than serum tumor makers in detecting early recurrence in patients with mucinous appendiceal neoplasm. MATERIALS AND METHODS: A total of 50 patients with appendiceal neoplasm (DPAM 11, PMCA 39) underwent abdominal and pelvic MRI prior to surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). Patients then entered follow-up surveillance with serial MRI every 6 months and serial laboratory studies including CA 125, CEA, and CA19-9...
April 2013: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/23031262/the-effect-of-protein-kinase-c-activator-and-nitric-oxide-donor-on-oocyte-activation-and-cortical-granule-exocytosis-in-porcine-eggs
#18
L Tůmová, R Romar, J Petr, M Sedmíková
Nitric oxide (NO) and protein kinase C (PKC) are involved in the activation of mammalian oocytes, although their role in the exit from the metaphase II stage and cortical granule (CG) exocytosis is still not fully understood. The aim of this study was to verify whether the NO-donor together with specific PKC-activators induce the complete activation of porcine oocytes assessed as meiosis resumption and a cortical reaction. Pig maturated oocytes were treated with the NO-donor S-nitroso-N-acetylpenicillamine (SNAP, 2 mM) or PKC-activators such as phorbol-12-myristate-13-acetate (PMA, 100 nM), 1-oleoyl-2-acetyl-sn-glycerol (OAG, 400 μM) and l-α-phosphatidylinositol-3,4,5-trisphosphate dipalmitoyl heptaammonium salt (DPAM, 2 μM)...
February 2013: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/22791943/pseudomyxoma-peritonei-of-92-chinese-patients-clinical-characteristics-pathological-classification-and-prognostic-factors
#19
Ai-Tao Guo, Yan-Mi Li, Li-Xin Wei
AIM: To assess the clinicopathologic features and its relationship with prognosis of pseudomyxoma peritonei (PMP) in Chinese patients. METHODS: The clinicopathologic features and follow-up data of 92 patients with PMP were reviewed and retrospectively analyzed. The cases were categorized into three groups: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and peritoneal mucinous carcinomatosis with intermediate or discordant features (PMCA-I/D)...
June 28, 2012: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/21493187/pseudomyxoma-peritonei-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-results-from-a-single-centre
#20
Álvaro Arjona-Sánchez, Francisco C Muñoz-Casares, Sebastián Rufián-Peña, Rafael Díaz-Nieto, Ángela Casado-Adam, María J Rubio-Pérez, Rosa Ortega-Salas
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare, slowly progressive disease whose prognosis depends primarily on the completeness of cytoreduction. The value of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and of additional factors predicting long-term outcome and disease-free survival (DFS) remains poorly understood. This study aims to analyse survival rates and prognostic factors in patients undergoing maximal cytoreduction and HIPEC. METHODS: Thirty patients were selected from a prospective database of records for patients undergoing cytoreduction and HIPEC with mitomycin C or paclitaxel...
April 2011: Clinical & Translational Oncology
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