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https://www.readbyqxmd.com/read/28300394/an-asymmetric-conformational-change-in-lacy
#1
Irina N Smirnova, Vladimir N Kasho, Xiaoxu Jiang, H Ronald Kaback
Galactoside/H+ symport by the lactose permease of Escherichia coli (LacY) involves reciprocal opening and closing of periplasmic and cytoplasmic cavities so that sugar- and H+-binding sites become alternatively accessible to either side of the membrane. After reconstitution into proteoliposomes, LacY with the periplasmic cavity sealed by cross-linking paired-Cys residues does not bind sugar from the periplasmic side. However, reduction of the S-S bond restores opening of the periplasmic cavity and galactoside binding...
March 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/28300280/rapamycin-attenuates-baff-extended-proliferation-and-survival-via-disruption-of-mtorc1-2-signaling-in-normal-and-neoplastic-b-lymphoid-cells
#2
Qingyu Zeng, Shanshan Qin, Hai Zhang, Beibei Liu, Jiamin Qin, Xiaoxue Wang, Ruijie Zhang, Chunxiao Liu, Xiaoqing Dong, Shuangquan Zhang, Shile Huang, Long Chen
B cell activating factor from the TNF family (BAFF) stimulates B-cell proliferation and survival, but excessive BAFF promotes the development of aggressive B cells leading to malignant and autoimmune diseases. Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble BAFF (hsBAFF)-stimulated B-cell proliferation/survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway. Here, we show that the inhibitory effect of rapamycin on hsBAFF-promoted B cell proliferation/survival is also related to blocking hsBAFF-stimulated phosphorylation of Akt, S6K1 and 4E-BP1, as well as expression of survivin in normal and B-lymphoid (Raji and Daudi) cells...
March 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28299373/examining-two-sets-of-introgression-lines-reveals-background-independent-and-stably-expressed-qtl-that-improve-grain-appearance-quality-in-rice-oryza-sativa-l
#3
Xianjin Qiu, Kai Chen, Wenkai Lv, Xiaoxue Ou, Yajun Zhu, Danying Xing, Longwei Yang, Fangjun Fan, Jie Yang, Jianlong Xu, Tianqing Zheng, Zhikang Li
A novel QTL cluster for appearance quality on Chr07 was identified using reciprocal introgression populations in different locations in China. Two secondary F 2 populations validated QTL with significant effect on appearance quality. Appearance quality (AQ) is the main determinants of market value of rice. Identification of QTL affecting AQ is the prerequisite for efficient improvement of AQ through marker-assisted selection (MAS). Two sets of reciprocal introgression lines derived from indica Minghui 63 and japonica 02428 were used to dissect the stability of QTL affecting five AQ traits, including grain length, grain width, length to width ratio, percentage of grains with chalkiness, and degree of endosperm chalkiness using 4568 bin genotype produced from 58,000 SNPs across five different environments...
March 15, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28296001/circulating-long-non-coding-rnas-nron-and-mhrt-as-novel-predictive-biomarkers-of-heart-failure
#4
Lina Xuan, Lihua Sun, Ying Zhang, Yuechao Huang, Yan Hou, Qingqi Li, Ying Guo, Bingbing Feng, Lina Cui, Xiaoxue Wang, Zhiguo Wang, Ye Tian, Bo Yu, Shu Wang, Chaoqian Xu, Mingyu Zhang, Zhimin Du, Yanjie Lu, Bao Feng Yang
This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for heart failure (HF). We measured the circulating levels of 13 individual lncRNAs which are known to be relevant to cardiovascular disease in the plasma samples from 72 HF patients and 60 non-HF control participants using real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) methods. We found that out of the 13 lncRNAs tested, non-coding repressor of NFAT (NRON) and myosin heavy-chain-associated RNA transcripts (MHRT) had significantly higher plasma levels in HF than in non-HF subjects: 3...
March 14, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28291778/efficacy-and-safety-of-5-hydroxytryptamine-3-receptor-antagonists-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Yongping Zheng, Ting Yu, Yurong Tang, Wenjie Xiong, Xiaoxue Shen, Ling Jiang, Lin Lin
AIM: We assessed the efficacy and safety of 5-hydroxytryptamine (5-HT3) receptor antagonists in adults with non-constipated irritable bowel syndrome (IBS) or diarrhea-predominant IBS (IBS-D). METHODS: We searched PubMed, MEDLINE, EMBASE, and the Cochrane Controlled Trials Register for randomized controlled trials (RCTs) involving adults with non-constipated IBS or IBS-D that compared 5-HT3 receptor antagonists with placebo or other conventional treatment. Dichotomous symptom data were pooled to obtain the relative risk (RR) and 95% confidence intervals (CIs) for improving global IBS symptoms, abdominal pain and abnormal bowel habits, or stool consistency symptoms after therapy, and adverse events, including constipation...
2017: PloS One
https://www.readbyqxmd.com/read/28290494/an-advanced-phase-retrieval-algorithm-in-n-step-phase-shifting-interferometry-with-unknown-phase-shifts
#6
Jiaosheng Li, Liyun Zhong, Shengde Liu, Yunfei Zhou, Jie Xu, Jindong Tian, Xiaoxu Lu
In phase-shifting interferometry with unknown phase shifts, a normalization and orthogonalization phase-shifting algorithm (NOPSA) is proposed to achieve phase retrieval. The background of interferogram is eliminated through using the orthogonality of complex sinusoidal function; and the influence of phase shifts deviation on accuracy of phase retrieval is avoided through both normalization and orthogonalization processing. Compared with the current algorithms with unknown phase shifts, the proposed algorithm reveals significantly faster computation speed, higher accuracy, better stability and non-sensitivity of phase shifts deviation...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288405/the-association-between-well-being-and-the-comt-gene-dispositional-gratitude-and-forgiveness-as-mediators
#7
Jinting Liu, Pingyuan Gong, Xiaoxue Gao, Xiaolin Zhou
BACKROUND: Previous studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being. METHODS: To investigate to what extent the COMT Val158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28274596/aberrant-expression-of-deubiquitylating-enzyme-usp9x-predicts-poor-prognosis-in-gastric-cancer
#8
Xiang Fu, Wei Xie, Xiaoxue Song, Kun Wu, Linkang Xiao, Yongqiang Liu, Lei Zhang
BACKGROUND: Ubiquitin-specific peptidase 9, X-linked (USP9X), a member of deubiquitylating enzymes family, has recently been reported to be associated with a variety of cancer progression. While it functions as either oncogene or tumor suppressor in a context-dependent manner, the expression and role of USP9X in gastric cancer is largely unknown. METHODS: Sixty-eight cases of patients with gastric cancer were enrolled in this study. The expression of USP9X and MCL1 were detected by immunohistochemistry...
March 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28274458/a-study-on-accumulation-of-volatile-organic-compounds-during-ochratoxin-a-biosynthesis-and-characterization-of-the-correlation-in-aspergillus-carbonarius-isolated-from-grape-and-dried-vine-fruit
#9
Xiaoxu Zhang, Zhan Cheng, Liyan Ma, Jingming Li
Volatile organic compounds (VOCs) and ochratoxin A (OTA) were detected in Aspergillus carbonarius strains (AF, SD26 and SD27) during a 7-day growing period, using HS-SPME-GC-MS and HPLC-MS/MS, respectively. Results showed that 33 VOCs were detected in these strains. The AF strain showed the different sesquiterpene profile compared with the other strains. Principal component analysis revealed that the AF strain was segregated from the other two strains regarding the VOC profile, especially the sesquiterpene profile...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28272406/o-glcnacylation-of-skn-1-modulates-the-lifespan-and-oxidative-stress-resistance-in-caenorhabditis-elegans
#10
Hongyuan Li, Xin Liu, Dan Wang, Liangping Su, Tingting Zhao, Zhongwei Li, Cong Lin, Yu Zhang, Baiqu Huang, Jun Lu, Xiaoxue Li
In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1 is regulated by its phosphorylation modification. However, whether other posttranslational modifications of SKN-1 affect its function remains unclear to date. Here we report, for the first time, that SKN-1 is O-GlcNAcylated at Ser470 and Thr493 by O-GlcNActransferase OGT-1. By generating the double mutations of Ser470/Thr493 in the wild type and skn-1(zu67) worms, respectively, we found that disruption of O-GlcNAc modification on SKN-1 repressed the accumulation of SKN-1 in the intestinal nuclei, and decreased the activities of SKN-1 in modulating lifespan and oxidative stress resistance...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271743/in-situ-sodium-persulfate-calcium-peroxide-oxidation-in-remediation-of-tph-contaminated-soil-in-3d-sand-box
#11
Hao Wu, Lina Sun, Hui Wang, Xiaoxu Wang
The aim of this article was to obtain the application parameters and conditions of in situ sodium persulfate/calcium peroxide oxidation. For the purposes of remediation, soil from a total petroleum hydrocarbons (TPH)-contaminated site was collected and prepared to reflect the actual stratum condition in a newly developed soil remediation modeling apparatus. Application methods of soil mixture, natural infiltration, direct injection and groundwater circulation were used to simulate in situ sodium persulfate oxidation in TPH-contaminated soil...
March 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28259905/matrix-stiffness-regulates-the-proliferation-stemness-and-chemoresistance-of-laryngeal-squamous-cancer-cells
#12
Lian Hui, Jingru Zhang, Xiaoxu Ding, Xing Guo, Xuejun Jiang
Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports...
February 15, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28257734/safe-zones-for-miniscrews-in-maxillary-dentition-distalization-assessed-with-cone-beam-computed-tomography
#13
Haibo Liu, Xiaoxue Wu, Lei Yang, Yin Ding
INTRODUCTION: The purpose of this study was to assess the anatomic structure of the buccal alveolar bone in the infrazygomatic crest region with cone-beam computed tomography to locate safe zones for miniscrews in maxillary dentition distalization. METHODS: The buccal alveolar bone was analyzed in 3 regions of 60 patients: between the maxillary second premolar and first molar (U5-U6), between the mesiodistal roots of the first molar (U6), and between the maxillary first and second molars (U6-U7)...
March 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28257056/interaction-of-type-iv-toxin-antitoxin-systems-in-cryptic-prophages-of-escherichia-coli-k-12
#14
Zhongling Wen, Pengxia Wang, Chenglong Sun, Yunxue Guo, Xiaoxue Wang
Toxin/antitoxin (TA) systems are widespread in prokaryotic chromosomes and in mobile genetic elements including plasmids and prophages. The first characterized Type IV TA system CbtA/CbeA was found in cryptic prophage CP4-44 in Escherichia coli K-12. Two homologous TA loci of CbtA/CbeA also reside in cryptic prophages of E. coli K-12, YkfI/YafW in CP4-6 and YpjF/YfjZ in CP4-57. In this study, we demonstrated that YkfI and YpjF inhibited cell growth and led to the formation of "lemon-shaped" cells. Prolonged overproduction of YkfI led to the formation of "gourd-shaped" cells and immediate cell lysis...
March 1, 2017: Toxins
https://www.readbyqxmd.com/read/28242719/tail-anchored-inner-membrane-protein-elab-increases-resistance-to-stress-while-reducing-persistence-in-escherichia-coli
#15
Yunxue Guo, Xiaoxiao Liu, Baiyuan Li, Jianyun Yao, Thomas K Wood, Xiaoxue Wang
Host-associated bacteria, such as Escherichia coli, often encounter various host-related stresses such as nutritional deprivation, oxidative stress and temperature shifts. There is growing interest in searching for small endogenous proteins that mediate stress responses. Here, we characterized a small C-tail anchored inner membrane protein ElaB in E. coli ElaB belongs to a class of tail-anchored inner membrane proteins with a C-terminal transmembrane domain but lacking an N-terminal signal sequence for membrane targeting...
February 27, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28241507/assessing-health-related-quality-of-life-of-chinese-adults-in-heilongjiang-using-eq-5d-3l
#16
Weidong Huang, Hongjuan Yu, Chaojie Liu, Guoxiang Liu, Qunhong Wu, Jin Zhou, Xin Zhang, Xiaowen Zhao, Linmei Shi, Xiaoxue Xu
This study aimed to assess health-related quality of life (HRQOL) of Heilongjiang adult populations by using the EuroQol five-dimension three-level (EQ-5D-3L) questionnaire and to identify factors associated with HRQOL. Data from the National Health Services Survey (NHSS) 2008 in Heilongjiang province were obtained. Results of EQ-5D-3L questionnaires completed by 11,523 adult respondents (18 years or older) were converted to health index scores using a recently developed Chinese value set. Multivariate linear regression and logistic regression models were established to determine demographic, socioeconomic, health, and lifestyle factors that were associated with HRQOL and reported problems in the five dimensions of EQ-5D-3L...
February 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230105/interface-confined-hydrogen-evolution-reaction-in-zero-valent-metal-nanoparticles-intercalated-molybdenum-disulfide
#17
Zhongxin Chen, Kai Leng, Xiaoxu Zhao, Souradip Malkhandi, Wei Tang, Bingbing Tian, Lei Dong, Lirong Zheng, Ming Lin, Boon Siang Yeo, Kian Ping Loh
Interface confined reactions, which can modulate the bonding of reactants with catalytic centres and influence the rate of the mass transport from bulk solution, have emerged as a viable strategy for achieving highly stable and selective catalysis. Here we demonstrate that 1T'-enriched lithiated molybdenum disulfide is a highly powerful reducing agent, which can be exploited for the in-situ reduction of metal ions within the inner planes of lithiated molybdenum disulfide to form a zero valent metal-intercalated molybdenum disulfide...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28230071/probing-the-molecular-mechanism-of-human-soluble-guanylate-cyclase-activation-by-no-in-vitro-and-in-vivo
#18
Jie Pan, Hong Yuan, Xiaoxue Zhang, Huijuan Zhang, Qiming Xu, Yajun Zhou, Li Tan, Shingo Nagawa, Zhong-Xian Huang, Xiangshi Tan
Soluble guanylate cyclase (sGC) is a heme-containing metalloprotein in NO-sGC-cGMP signaling. NO binds to the heme of sGC to catalyze the synthesis of the second messenger cGMP, which plays a critical role in several physiological processes. However, the molecular mechanism for sGC to mediate the NO signaling remains unclear. Here fluorophore FlAsH-EDT2 and fluorescent proteins were employed to study the NO-induced sGC activation. FlAsH-EDT2 labeling study revealed that NO binding to the H-NOX domain of sGC increased the distance between H-NOX and PAS domain and the separation between H-NOX and coiled-coil domain...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229067/the-effect-of-world-trade-center-exposure-on-the-timing-of-diagnoses-of-obstructive-airway-disease-chronic-rhinosinusitis-and-gastroesophageal-reflux-disease
#19
Xiaoxue Liu, Jennifer Yip, Rachel Zeig-Owens, Jessica Weakley, Mayris P Webber, Theresa M Schwartz, David J Prezant, Michael D Weiden, Charles B Hall
OBJECTIVES: In a cohort of rescue/recovery workers exposed to the dust that resulted from the collapse of the World Trade Center (WTC), we assessed how a diagnosis of obstructive airways disease (OAD) affected the likelihood of a subsequent diagnosis of chronic rhinosinusitis (CRS) or gastroesophageal reflux disease (GERD). We also assessed whether OAD acted as a mediator of the association between exposure to the WTC rescue/recovery effort and CRS and GERD diagnoses. METHODS: In this prospective cohort study, we analyzed Fire Department of the City of New York physician diagnoses of OAD, CRS, and GERD that were first documented between September 11, 2001, and September 10, 2011, among 8,968 WTC-exposed firefighters...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28226182/effect-of-different-solvents-on-the-measurement-of-phenolics-and-the-antioxidant-activity-of-mulberry-morus-atropurpurea-roxb-with-accelerated-solvent-extraction
#20
Jiufang Yang, XiaoQun Ou, Xiaoxu Zhang, ZiYing Zhou, LiYan Ma
The effects of 9 different solvents on the measurement of the total phenolics and antioxidant activities of mulberry fruits were studied using accelerated solvent extraction (ASE). Sixteen to 22 types of phenolics (flavonols, flavan-3-ols, flavanol, hydroxycinnamic acids, hydroxybenzoic acids, and stilbenes) from different mulberry extracts were characterized and quantified using HPLC-MS/MS. The principal component analysis (PCA) was used to determine the suitable solvents to distinguish between different classes of phenolics...
February 22, 2017: Journal of Food Science
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