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https://www.readbyqxmd.com/read/29334326/predicting-the-dopamine-d2-receptor-occupancy-of-ropinirole-in-rats-using-positron-emission-tomography-and-pharmacokinetic-pharmacodynamic-modeling
#1
Chenrong Huang, Ziteng Wang, Linsheng Liu, Xiaoxue Liu, Ji Dong, Qingqing Xu, Bin Zhang, Liyan Miao
The purpose of this study was to measure dopamine D2/3 receptor occupancy (RO) as a marker of the clinical efficacy of ropinirole in rats via positron emission tomography (PET) using 18F-fallypride as the radiotracer and to explore the relationship between dopamine RO and the plasma concentration of ropinirole via pharmacokinetic-pharmacodynamic modeling. Plasma was collected from 16 rats treated with one of four doses of ropinirole. For the time-dependent study, the data of 16 rats in the 15 mg/kg dose group at four time points were averaged, and another 24 rats were divided into three dose groups (5 mg/kg, 30 mg/kg and 60 mg/kg) for the dose-dependent study; the animals were assessed via 18F-fallypride PET scans...
January 15, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29327633/biochemical-basis-for-the-age-related-sensitivity-of-broilers-to-aflatoxin-b1
#2
He Wang, Wei Li, Ishfaq Muhammad, Xiaoqi Sun, Xiaoxu Cui, Ping Cheng, Qayum Abdul, Xiuying Zhang
In this study, we investigated the mechanism underlying age-related susceptibility in broilers to aflatoxin B1 (AFB1). The results showed that AFB1 induced significant changes in serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) activity & liver superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) activity at day 7, 21 and 42 relative to control group. However, AFB1-induced changes in serum biochemical parameters and liver antioxidant activities becomes less severe with increasing age of broilers...
January 12, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29323284/phases-and-rates-of-iron-and-magnetism-changes-during-paddy-soil-development-on-calcareous-marine-sediment-and-acid-quaternary-red-clay
#3
Laiming Huang, Xiaoxu Jia, Ming'an Shao, Liumei Chen, Guangzhong Han, Ganlin Zhang
Dynamic changes in Fe oxides and magnetic properties during natural pedogenesis are well documented, but variations and controls of Fe and magnetism changes during anthropedogenesis of paddy soils strongly affected by human activities remain poorly understood. We investigated temporal changes in different Fe pools and magnetic parameters in soil profiles from two contrasting paddy soil chronosequences developed on calcareous marine sediment and acid Quaternary red clay in Southern China to understand the directions, phases and rates of Fe and magnetism evolution in Anthrosols...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321171/sgk1-foxo3-signaling-in-hypothalamic-pomc-neurons-mediates-glucocorticoid-increased-adiposity
#4
Yalan Deng, Yuzhong Xiao, Feixiang Yuan, Yaping Liu, Xiaoxue Jiang, Jiali Deng, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Shanghai Chen, Yan Chen, Hao Ying, Qiwei Zhai, Yousheng Shu, Feifan Guo
Although central nervous system has been implicated in glucocorticoid-induced fat mass gain, the underlying mechanisms are poorly understood. The aim of our current study was to investigate the possible involvement of hypothalamic serum- and glucocorticoid-regulated kinase 1 (SGK1) in glucocorticoid-increased adiposity. It is well-known that SGK1 expression is induced by acute glucocorticoid treatment, interestingly, we found its expression was decreased in the arcuate nucleus of the hypothalamus, including POMC neurons, following chronic dexamethasone (Dex) treatment...
January 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29319712/3-d-and-electrically-conducting-functional-skin-mapping-for-biomedical-applications
#5
Xiaoxu Fu, Wenqiu Zeng, Ana C Ramírez-Pérez, Grzegorz Lisak
Ex situ and in situ 3-D and electrically conducting mapping of the skin topography via electropolymerization of a conducting polymer on a previously sampled skin stamp or directly on the skin of a live human subject were performed here with the intention to be further used in biomedical applications.
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29317452/autophagy-sustains-pancreatic-cancer-growth-through-both-cell-autonomous-and-non-autonomous-mechanisms
#6
Annan Yang, Grit Herter-Sprie, Haikuo Zhang, Elaine Y Lin, Douglas Biancur, Xiaoxu Wang, Jiehui Deng, Josephine Hai, Shenghong Yang, Kwok-Kin Wong, Alec C Kimmelman
Autophagy has been shown to be elevated in pancreatic adenocarcinoma (PDAC) and its role in promoting established tumor growth has made it a promising therapeutic target. However, due to limitations of prior mouse models as well as the lack of potent and selective autophagy inhibitors, the ability to fully assess the mechanistic basis of how autophagy supports pancreatic cancer has been limited. To test the feasibility of treating PDAC using autophagy inhibition and further our understanding of the mechanisms of pro-tumor effects of autophagy, we developed a novel mouse model that allowed the acute and reversible inhibition of autophagy...
January 9, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29311606/controllable-deuteration-of-halogenated-compounds-by-photocatalytic-d2o-splitting
#7
Cuibo Liu, Zhongxin Chen, Chenliang Su, Xiaoxu Zhao, Qiang Gao, Guo-Hong Ning, Hai Zhu, Wei Tang, Kai Leng, Wei Fu, Bingbing Tian, Xinwen Peng, Jing Li, Qing-Hua Xu, Wu Zhou, Kian Ping Loh
Deuterium labeling is of great value in organic synthesis and the pharmaceutical industry. However, the state-of-the-art C-H/C-D exchange using noble metal catalysts or strong bases/acids suffers from poor functional group tolerances, poor selectivity and lack of scope for generating molecular complexity. Herein, we demonstrate the deuteration of halides using heavy water as the deuteration reagent and porous CdSe nanosheets as the catalyst. The deuteration mechanism involves the generation of highly active carbon and deuterium radicals via photoinduced electron transfer from CdSe to the substrates, followed by tandem radicals coupling process, which is mechanistically distinct from the traditional methods involving deuterium cations or anions...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29311547/a-non-dispersion-strategy-for-large-scale-production-of-ultra-high-concentration-graphene-slurries-in-water
#8
Lei Dong, Zhongxin Chen, Xiaoxu Zhao, Jianhua Ma, Shan Lin, Mengxiong Li, Yang Bao, Leiqiang Chu, Kai Leng, Hongbin Lu, Kian Ping Loh
It is difficult to achieve high efficiency production of hydrophobic graphene by liquid phase exfoliation due to its poor dispersibility and the tendency of graphene sheets to undergo π-π stacking. Here, we report a water-phase, non-dispersion exfoliation method to produce highly crystalline graphene flakes, which can be stored in the form of a concentrated slurry (50 mg mL-1) or filter cake for months without the risk of re-stacking. The as-exfoliated graphene slurry can be directly used for 3D printing, as well as fabricating conductive graphene aerogels and graphene-polymer composites, thus avoiding the use of copious quantities of organic solvents and lowering the manufacturing cost...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29306189/effects-of-microcystis-aeruginosa-on-the-expression-of-nuclear-receptor-genes-in-daphnia-similoides-sinensis
#9
Xiaoxue Xu, Ya-Nan Zhang, Shuixiu Peng, Jianxun Wu, Daogui Deng, Zhongze Zhou
Nuclear receptor (NR) genes form a conserved superfamily, which is involved in organism metabolism, reproduction, development, homeostasis, and resource allocation. Microcystis aeruginosa can inhibit the growth and reproduction of Daphnia. However, whether M. aeruginosa can affect the expression of Daphnia NR genes is unknown. In total, 18 NRs were identified in this study based on previous Daphnia similoides sinensis transcriptome data. In treatments containing M. aeruginosa, the gene expression of the NR1 subfamily (E75a, E75b, HR3, HR96, NHR-1, HR97a, HR97g, and NHR97) and the NR2 subfamily (RXR, TLL, PNR, and SVP) were down-regulated 59% and 79%, respectively...
January 3, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29300062/facile-synthesis-and-color-tunable-properties-of-monodisperse-%C3%AE-nayf4-ln3-ln-eu-tb-tm-sm-ho-microtubes
#10
Junfeng Yang, Lina Song, Xiaoxue Wang, Jianchao Dong, Shucai Gan, Lianchun Zou
In this study, monodisperse and uniform β-NaYF4 hexagonal microtubes were successfully synthesized via a simple hydrothermal method without any organic surfactants, employing Y(OH)CO3 colloid spheres as precursors. The possible formation mechanism was studied on the basis of a series of time-dependent control experiments and its intrinsic crystal structure. The integrated emission intensity of β-NaYF4:0.05Tb3+ is almost 1.78 times stronger than that of α-NaYF4:0.05Tb3+. In addition, the photoluminescence properties of β-NaYF4:Ln3+ (Ln = Eu, Tb, Tm, Sm, Ho) were studied in detail, and it was found that the photoluminescence color of β-NaYF4:0...
January 4, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29291519/degradation-of-the-uv-filter-benzophenone-3-in-aqueous-solution-using-persulfate-activated-by-heat-metal-ions-and-light
#11
Xiaoxue Pan, Liqing Yan, Ruijuan Qu, Zunyao Wang
The goals of this study were to bring forward new data and insights into the effect of activation methods, operational variables and reaction pathways during sulfate radicals-based oxidation of benzophenone-3 (BP-3) in aqueous solution. Heat, transition metal ions (Fe2+, Cu2+, Co2+), UV and visible light irradiation were used to activate persulfate (PS) to degrade BP-3. The results showed that these three activation methods can remarkably enhance BP-3 removal efficiency. Under the conditions of [BP-3]0: [PS]0 = 1: 500, pH = 7...
December 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29290173/comparison-of-specialty-medication-use-for-common-chronic-inflammatory-diseases-among-health-exchange-and-other-commercially-insured-members
#12
Xiaoxue Chen, Santosh Gautam, Alexander Ruggieri, Thomas Richards, Andrea Devries, Gosia Sylwestrzak
BACKGROUND: The Affordable Care Act of 2010 allows the purchase of health insurance through special marketplaces called "health exchanges." The majority of individuals enrolling in the exchanges were previously uninsured, older, and sicker than other commercially insured members. Early evidence also suggests that exchange plan members use more costly specialty drugs compared with other commercially insured members. OBJECTIVES: To (a) examine patient characteristics and specialty drug use for common chronic inflammatory diseases (CIDs) among exchange plan members compared with other commercially insured members and (b) explore variations in specialty drug use within exchange plans by metal tiers (bronze, silver, gold, and platinum), as well as across local markets...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29285934/synthetic-polymeric-mixed-micelles-target-to-lymph-node-triggering-enhanced-cellular-and-humoral-immune-responses
#13
Chenxi Li, Xiaoxu Zhang, Qing Chen, Jiulong Zhang, Wenpan Li, Haiyang Hu, Xiuli Zhao, Mingxi Qiao, Dawei Chen
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines since antigen presentation and initiation of T cell-mediated immune responses occur primarily at these locations. In this study, amphiphilic diblock copolymer PEOz-PLA combined with carboxylterminalted-Pluronic F127 were used to construct mixed micelles (carboxylated-NPs) for co-delivery of antigen OVA and Toll-like receptor-7 agonist CL264 (carboxylated-NPs/OVA/CL264) to the LN resident DCs. The results showed that the small, sub-60nm size of the self-assembled mixed micelles enables them to rapidly penetrate into lymphatic vessels and reach DLNs after subcutaneous injection...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29283322/optimal-river-monitoring-network-using-optimal-partition-analysis-a-case-study-of-hun-river-northeast-china
#14
Hui Wang, Chunyue Liu, Luge Rong, Xiaoxu Wang, Lina Sun, Qing Luo, Hao Wu
River monitoring networks play an important role in water environmental management and assessment, and it is critical to develop an appropriate method to optimize the monitoring network. In this study, an effective method was proposed based on the attainment rate of National Grade III water quality, optimal partition analysis and Euclidean distance, and Hun River was taken as a method validation case. There were seven sampling sites in the monitoring network of the Hun River, and seventeen monitoring items were analyzed once a month during January 2009 to December 2010...
December 28, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29280127/-three-methods-for-controlling-presacral-massive-bleeding-during-pelvic-operations
#15
Xiaoxue Wang, Zhimin Liu, Shangkui Xie, Donglin Ren, Yin'ai Wu
OBJECTIVE: To evaluate three different methods for controlling presacral massive bleeding during pelvic operations. METHODS: Clinical data of 11 patients with presacral massive bleeding during pelvic operation at The Sixth Affiliated Hospital of Sun Yat-sen University and 157 Branch Hospital of Guangzhou General Hospital of Guangzhou Military Command from January 2001 to January 2016 were analyzed retrospectively. Hemostasis methods for presacral massive bleeding during operation included gauze packing (whole pressure), drawing pin (local pressure) and absorbable gauze (absorbable gauze was adhered to bleeding position with medical glue after local pressure)...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29274749/the-genetic-polymorphisms-of-tgf%C3%AE-superfamily-genes-are-associated-with-litter-size-in-a-chinese-indigenous-sheep-breed-hu-sheep
#16
Weimin Wang, Yongfu La, Xiang Zhou, Xiaoxue Zhang, Fadi Li, Bang Liu
Litter size, which is a complex economic trait in sheep, is affected by polygenes. Hu sheep are a prolific native breed in China and also an ideal resource for studying the genetic mechanism that controls litter size in sheep. In this study, we investigated the genetic effects of candidate genes on litter size in a large experimental population (n = 2021) of Hu sheep. A total of 23 single nucleotide polymorphisms (SNPs) including six reported major mutations (FecB, FecXI, FecXB, FecXH, FecGI, and FecGH) and 17 novel SNPs in 10 candidate genes involved in reproduction were genotyped using KASPar technology...
December 16, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29251334/niclosamide-acts-as-a-new-inhibitor-of-vasculogenic-mimicry-in-oral-cancer-through-upregulation-of-mir-124-and-downregulation-of-stat3
#17
Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wang
Tumors require nutrients and oxygen for growth and metastasis. Vasculogenic mimicry (VM) has been found as a new manner of blood supply, which is characterized as the formation of tumor cell-lined vessels instead of endothelial vessels. This is why angiogenesis agents targeted to endothelial cells show a limited efficacy. Up to this point, there is no effective drug reported for inhibiting VM formation. Niclosamide is an oral anti-helminthic drug used to treat human tapeworms. Recent studies have indicated that niclosamide has broad applications for cancer and other diseases...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29246308/mir-3174-contributes-to-apoptosis-and-autophagic-cell-death-defects-in-gastric-cancer-cells-by-targeting-arhgap10
#18
Bowen Li, Lu Wang, Zheng Li, Weizhi Wang, Xiaofei Zhi, Xiaoxu Huang, Qiang Zhang, Zheng Chen, Xuan Zhang, Zhongyuan He, Jianghao Xu, Lu Zhang, Hao Xu, Diancai Zhang, Zekuan Xu
Gastric cancer (GC) is a major health problem worldwide because of its high morbidity and mortality. Considering the well-established roles of miRNA in the regulation of GC carcinogenesis and progression, we screened differentially expressed microRNAs (miRNAs) by using The Cancer Genome Atlas (TCGA) and the GEO databases. We found that miR-3174 was the most significantly differentially expressed miRNA in GC. Ectopic miR-3174 expression was also detected in clinical GC patient samples and cell lines and associated with poor patient prognosis...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29241787/prognosis-treatment-and-disease-outcomes-in-frontal-fibrosing-alopecia-a-retrospective-review-of-92-cases
#19
Lauren C Strazzulla, Lorena Avila, Xiaoxue Li, Kristen Lo Sicco, Jerry Shapiro
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241063/red-warning-for-air-pollution-in-china-exploring-residents-perceptions-of-the-first-two-red-warnings-in-beijing
#20
Hanping Zhao, Fangping Wang, Chence Niu, Han Wang, Xiaoxue Zhang
Air pollution early warnings have been issued in China to mitigate the effects of high pollution days. Public perceptions and views about early warning signals can affect individual behaviors and play a major role in the public's response to air pollution risks. This study examined public attitudes and responses to the first two red warnings for air pollution in Beijing in 2015. An online survey was sent out, and 664 respondents (response rate = 90%) provided their perspectives on the red warnings. Descriptive statistics, sign tests and binary logit models were used to analyze the data...
December 11, 2017: Environmental Research
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