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https://www.readbyqxmd.com/read/28442201/temporal-variations-in-physiological-responses-of-kandelia-obovata-seedlings-exposed-to-multiple-heavy-metals
#1
Shanshan Cheng, Nora Fung Yee Tam, Ruili Li, Xiaoxue Shen, Zhiyuan Niu, Minwei Chai, Guo Yu Qiu
A study was conducted to quantify temporal variations in physiological responses of Kandelia obovata under multiple heavy metal stress. The results showed that plant growth was not significantly affected by multiple heavy metal stress during the 120-days experiment. At the start, levels of net photosynthetic rate (Pn), stomatal conductance (Gs) and transpiration rate (Tr) showed effects of "low-promotion, high-inhibition", but Pn and Gs reduced with increasing heavy metal stress at the end. Temporary lipid oxidation was shown by high levels of malondialdehyde (MDA) under high heavy metal stress at the start but was unaffected at the end of the experiment...
April 22, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28439667/myricetin-induced-brown-adipose-tissue-activation-prevents-obesity-and-insulin-resistance-in-db-db-mice
#2
Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
PURPOSE: Myricetin, a dietary flavonoid, is effective in the treatment of obesity and insulin resistance by increasing glucose transport and lipogenesis in adipocyte and diminishing systemic inflammation in obesity. However, it has not been revealed yet whether myricetin is associated with brown adipose tissue (BAT) activation that tightly mediates systemic energy metabolism. Therefore, this study assessed whether myricetin activated brown adipose tissue in db/db mouse. METHODS: Myricetin (400 mg/kg) in distilled water was fed daily by oral gavage to leptin receptor-deficient db/db male mice at 4 weeks of age for 14 weeks...
April 24, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28437117/optimal-sensitizer-concentration-in-single-upconversion-nanocrystals
#3
Chenshuo Ma, Xiaoxue Xu, Fan Wang, Zhiguang Zhou, Deming Liu, Jiangbo Zhao, Ming Guan, Candace I Lang, Dayong Jin
Each single upconversion nanocrystal (UCNC) usually contains thousands of photon sensitizers and hundreds of photon activators to up-convert near infrared photons into visible and ultraviolet emissions. Though in principle further increasing the sensitizers' concentration will enhance the absorption efficiency to produce brighter nanocrystals, typically 20% of Yb3+ ions has been used to avoid the so-called "concentration quenching" effect. Here we report that concentration quenching effect does not limit the sensitizer concentration and NaYbF4 is the most bright host matrix...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28431168/identifying-new-susceptibility-genes-on-dopaminergic-and-serotonergic-pathways-for-the-framing-effect-in-decision-making
#4
Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zhou
The framing effect refers the tendency to be risk-averse when options are presented positively but be risk-seeking when the same options are presented negatively during decision-making. This effect has been found to be modulated by the serotonin transporter gene (SLC6A4) and the catechol-o-methyltransferase gene (COMT) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. The current study aimed to identify new genetic variations of genes on dopaminergic and serotonergic pathways that may contribute to individual differences in the susceptibility to framing...
April 19, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28428633/inhibition-of-glutathione-metabolism-attenuates-esophageal-cancer-progression
#5
Liang Peng, Ruixia Linghu, Demeng Chen, Jing Yang, Xiaoxue Kou, Xiang-Zhen Wang, Yi Hu, Yi-Zhou Jiang, Junlan Yang
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, and the 5-year survival rate for all patients diagnosed with ESCC remains poor. A better understanding of the biological mechanisms of ESCC tumorigenesis and progression is of great importance to improve treatment of this disease. In this study, we demonstrated that the glutathione metabolism pathway is highly enriched in ESCC cells compared with normal esophageal epithelial cells in an in vivo mouse model...
April 21, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28428008/force-development-and-intracellular-ca-2-in-intact-cardiac-muscles-from-gravin-mutant-mice
#6
Zhitao Li, Sonal Singh, Santosh V Suryavanshi, Wengang Ding, Xiaoxu Shen, Cori S Wijaya, Wei Dong Gao, Bradley K McConnell
Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β2-adrenergic receptor (β2-AR), protein phosphatase 2B and protein kinase C. Gravin facilitates β2-AR-dependent signal transduction through PKA to modulate cardiac excitation-contraction coupling and its removal positively affects cardiac contraction. Trabeculae from the right ventricles of gravin mutant (gravin-t/t) mice were employed for force determination. Simultaneously, corresponding intracellular Ca(2+) transient ([Ca(2+)]i) were measured...
April 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28418286/external-application-of-nf-%C3%AE%C2%BAb-inhibitor-dhmeq-suppresses-development-of-atopic-dermatitis-like-lesions-induced-with-dncb-ox-in-balb-c-mice
#7
Xiaoxue Jiang, Yi Lan, Bing Wei, Cailing Dai, Yaru Gu, Jun Ma, Xiaoyan Liu, Kazuo Umezawa, Yuyang Zhang
CONTEXT: Dehydroxymethylepoxyquinomicin (DHMEQ) which is originally developed as an analog of antibiotic epoxyquinomicin C is a specific and potent inhibitor of NF-κB and has been shown to possess promising potential as an anti-inflammatory and anti-tumor agent. OBJECTIVE: This study examines DHMEQ's effect on therapeutic potential for atopic dermatitis (AD)-like lesions. MATERIALS AND METHODS: AD lesions were chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears in BALB/c mice...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28415724/pharmacological-inhibition-of-src-kinase-protects-against-acute-kidney-injury-in-a-murine-model-of-renal-ischemia-reperfusion
#8
Chongxiang Xiong, Xiujuan Zang, Xiaoxu Zhou, Lirong Liu, Monica V Masucci, Jinhua Tang, Xuezhu Li, Na Liu, George Bayliss, Ting C Zhao, Shougang Zhuang
Activation of Src kinase has been implicated in the pathogenesis of acute brain, liver, and lung injury. However, the role of Src in acute kidney injury (AKI) remains unestablished. To address this, we evaluated the effects of Src inhibition on renal dysfunction and pathological changes in a murine model of AKI induced by ischemia/reperfusion (I/R). I/R injury to the kidney resulted in increased Src phosphorylation at tyrosine 416 (activation). Administration of PP1, a highly selective Src inhibitor, blocked Src phosphorylation, improved renal function and ameliorated renal pathological damage...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414999/enhanced-adsorption-of-bromate-from-aqueous-solutions-on-ordered-mesoporous-mg-al-layered-double-hydroxides-ldhs
#9
Huashun Ji, Wenhao Wu, Feihu Li, Xiaoxue Yu, Jingjing Fu, Luyao Jia
An ordered mesoporous Mg-Al layered double hydroxide (meso-LDH350) with a fairly high Brunauer-Emmett-Teller (BET) surface area (126m(2)g(-1)) has been facilely synthesized and then evaluated for the adsorptive removal of bromate from aqueous solutions. Adsorbents were characterized by a variety of techniques (e.g., XRD, FTIR, SEM, TG-DSC, N2 physisorption, XPS, etc.). The adsorption studies indicated that the presence of background electrolytes and competitive anions can obviously repress the uptake of bromate on LDHs...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28407331/room-temperature-sensing-achieved-by-gaas-nanowires-and-ocvd-polymer-coating
#10
Xiaoxue Wang, Sema Ermez, Hilal Goktas, Silvija Gradečak, Karen Gleason
Novel structures comprised of GaAs nanowire arrays conformally coated with conducting polymers (poly(3,4-ethylenedioxythiophene) (PEDOT) or poly(3,4-ethylenedioxythiophene-co-3-thiophene acetic acid) display both sensitivity and selectivity to a variety of volatile organic chemicals. A key feature is room temperature operation, so that neither a heater nor the power it would consume, is required. It is a distinct difference from traditional metal oxide sensors, which typically require elevated operational temperature...
April 13, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28402919/inhibition-of-mir-363-protects-cardiomyocytes-against-hypoxia-induced-apoptosis-through-regulation-of-notch-signaling
#11
Xiaoxue Meng, Yuqiang Ji, Zhaofei Wan, Bo Zhao, Chuanjie Feng, Jiang Zhao, Hua Li, Yanbin Song
Cardiomyocyte apoptosis contributes to the pathological process of ischemic heart diseases, such as myocardial infarction. Emerging evidence suggests that microRNAs (miRNAs) play critical roles in the pathological process of myocardial infarction by regulating cardiomyocyte apoptosis. Previous studies have reported that miR-363 is an apoptosis-related miRNA. However, whether miR-363 is involved in regulating cardiomyocyte apoptosis remains unclear. This study aimed to investigate the potential role of miR-363 in the regulation of hypoxia-induced cardiomyocyte apoptosis...
April 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28399139/ibutilide-treatment-protects-against-er-stress-induced-apoptosis-by-regulating-calumenin-expression-in-tunicamycin-treated-cardiomyocytes
#12
Yu Wang, Liying Xuan, Xiaoxue Cui, Yilin Wang, Shaoqing Chen, Chengxi Wei, Ming Zhao
BACKGROUND: Ibutilide, a class III antiarrhythmic agent has been shown to be cardioprotective in treating atrial fibrillation, promoting cardioconversion and recently this agent has been shown to protect against ER stress induced apoptosis in cardiomyocytes. In this study we begin to identify the mechanism by which ibutilide exerts its cardioprotection in tunicamycin treated cardiomyocytes. We examined ER stress markers including calumenin; a calcium binding ER chaperone protein that has recently been linked to ER stress in cardiomyocytes, in our treated cells...
2017: PloS One
https://www.readbyqxmd.com/read/28392509/bioequivalence-and-pharmacokinetic-profiles-of-agomelatine-25-mg-tablets-in-healthy-chinese-subjects-a-four-way-replicate-crossover-study-demonstrating-high-intra-and-inter-individual-variations
#13
Cuiyun Li, Jing Xu, Yan Zheng, Guiling Chen, Jianmeng Wang, Liying Ma, Yan Qiao, Junqi Niu, Min Wu, Hong Zhang, Xiaojiiao Li, Hong Chen, Xiaoxue Zhu, Chengjiao Liu, Yanhua Ding
The present study was designed to assess the bioequivalence of two agomelatine formulations (25-mg tablets) in healthy Chinese male subjects. This single-dose, open-label, randomized, four-way replicate study with a 1-week washout period was conducted in 60 healthy Chinese male volunteers under fasting conditions. Blood samples were collected over a 12-h period after a single dose of the 25-mg agomelatine test (T) formulation or a reference (R) formulation, and the drug concentrations were assayed by liquid chromatography tandem mass spectrometry (LC-MS/MS)...
April 8, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28380843/improved-phase-retrieval-method-of-dual-wavelength-interferometry-based-on-a-shorter-synthetic-wavelength
#14
Jiaxiang Xiong, Liyun Zhong, Shengde Liu, Xiang Qiu, Yunfei Zhou, Jindong Tian, Xiaoxu Lu
In dual-wavelength interferometry (DWI), by combing the advantage of the shorter synthetic-wavelength and the immune algorithm of phase ambiguity, we propose an improved phase retrieval method with both high accuracy and large measurement range, which is a pair of contradiction in the reported DWI method. First, we calculate the height of measured object at longer synthetic-wavelength through using the wrapped phases of two single-wavelengths. Second, by combining the immune algorithm of phase ambiguity and the height of measured object at longer synthetic-wavelength, we can perform the phase unwrapping of the larger one of the two single-wavelengths, then achieve accurate height at single-wavelength named as the transition height...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28380842/general-spatial-phase-shifting-interferometry-by-optimizing-the-signal-retrieving-function
#15
Yi Wang, Xiang Qiu, Jiaxiang Xiong, Bingbo Li, Liyun Zhong, Shengde Liu, Yunfei Zhou, Jindong Tian, Xiaoxu Lu
A general spatial phase-shifting (GSPS) interferometry method is proposed to achieve phase retrieval from one-frame spatial carrier frequency interferogram. By optimizing the internal signal retrieving function of the spatial phase-shifting (SPS) method, the accuracy, anti-noise ability and speed of phase retrieval can be significantly improved, meanwhile the corresponding local calculation property is reserved. Especially, in the case that the ratio of the spatial carrier to the phase variation rate are small, the proposed method reveals obvious advantage in the accuracy improvement relative to the conventional SPS methods, so the more details of measured sample can be effectively reserved through introducing smaller spatial carrier frequency, and this will facilitate its application in interference microscopy...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28362327/the-salutary-influence-of-forest-bathing-on-elderly-patients-with-chronic-heart-failure
#16
Genxiang Mao, Yongbao Cao, Bozhong Wang, Sanying Wang, Zhuomei Chen, Jirong Wang, Wenmin Xing, Xiaoxu Ren, Xiaoling Lv, Jianhua Dong, Shasha Chen, Xiuyuan Chen, Guofu Wang, Jing Yan
The aim of the current study was to test the hypothesis that forest bathing would be beneficial for elderly patients with chronic heart failure (CHF) as an adjunctive therapy. Two groups of participants with CHF were simultaneously sent to the forest or an urban control area for a four-day trip, respectively. Subjects exposed to the forest site showed a significant reduction of brain natriuretic peptide (BNP) in comparison to that of the city group and their own baseline levels. The values for the cardiovascular disease related pathological factors, including endothelin-1 (ET-1), and constituents of the renin-angiotensin system (RAS), including renin, angiotensinogen (AGT), angiotensin II (ANGII), and ANGII receptor type 1 or 2 (AT1 or AT2) in subjects exposed to the forest environment were lower than those in the urban control group...
March 31, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28351807/profiles-sources-and-potential-exposures-of-parent-chlorinated-and-brominated-polycyclic-aromatic-hydrocarbons-in-haze-associated-atmosphere
#17
Rong Jin, Guorui Liu, Xiaoxu Jiang, Yong Liang, Heidelore Fiedler, Lili Yang, Qingqing Zhu, Yang Xu, Lirong Gao, Guijin Su, Ke Xiao, Minghui Zheng
Profiles, sources and potential exposures of chlorinated and brominated polycyclic aromatic hydrocarbons (ClPAHs and BrPAHs) in haze associated atmosphere remain unclear. Haze events happened frequently during heating period in Beijing provided a typical urban context to investigate the concentrations, profiles, sources and potential exposures of ClPAHs, BrPAHs and their non-halogenated parent compounds (PAHs) in air samples. Average concentrations of PAHs, ClPAHs and BrPAHs during heating periods (with more frequent haze events) were about 3-9 times higher than during non-heating periods...
March 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28349889/association-between-cumulative-exposure-to-ideal-cardiovascular-health-and-arterial-stiffness
#18
Xiaoming Zheng, Ruiying Zhang, Xiaoxue Liu, Haiyan Zhao, Hongmin Liu, Jingsheng Gao, Yuntao Wu, Shouling Wu
BACKGROUND AND AIMS: Ideal cardiovascular health (CVH) is associated with reduced risk of cardiac and cerebral events. Arterial stiffness plays an important role in the progress of cardiac and cerebral events, but it is unclear whether ideal CVH, in particular, cumulative exposure to ideal CVH (cumCVH), is associated with reduced risk of arterial stiffness. We examined the association between cumCVH and arterial stiffness using data from the Kailuan Study. METHODS: The study cohort consisted of 20,355 participants from the Kailuan community-based cohort, whose mean follow-up period was 3...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28341133/sperm-cryopreservation-in-the-spermcasting-australian-flat-oyster-ostrea-angasi-by-a-programmable-freezing-method
#19
Md Mahbubul Hassan, Xiaoxu Li, Yibing Liu, Jian G Qin
Cryopreservation offers long-term storage of gametes without constraint from seasonal gamete maturation, provides opportunities to improve the efficiency of breeding and genetic programs, and protects endangered species from extinction due to epidemic diseases and natural disasters. In this study, a protocol for cryopreserving sperm of the spermcasting Australian flat oyster Ostrea angasi was developed by optimizing key factors influencing the quality of cryopreserved sperm. Dimethyl sulfoxide (DMSO) was non-toxic to sperm within the concentration and duration assessed in the toxicity experiment whereas 10% methanol or a higher concentration was toxic to sperm from the exposure duration of 30 min onwards...
March 21, 2017: Cryobiology
https://www.readbyqxmd.com/read/28340755/single-molecule-transformation-and-analysis-of-glutathione-oxidized-and-reduced-in-nanopore
#20
Yongfeng Wei, Zhuoqun Su, Xiao-Feng Kang, Yanli Guo, Xiaoxue Mu
The determination of glutathione reduced (GSH) or oxidized (GSSG) in bulk solution has been reported previously. However, it is critically important to set up a simple and label-free method to recognize GSSG and GSH selectively and dynamically, especially at a single-molecule level. Here we report a novel nanopore method to recognize GSSG based on a newly synthesized per-6-quaternary ammonium-β-cyclodextrin (p-QABCD), which is used as both the molecular adaptor of protein nanopore and the recognizing element of GSSG...
May 15, 2017: Talanta
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