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https://www.readbyqxmd.com/read/29792732/phosphatidylinositol-3-kinase-%C3%AE-and-%C3%AE-isoforms-play-key-roles-in-metastasis-of-prostate-cancer-du145-cells
#1
Zhe Zhang, Jie Liu, Yingying Wang, Xiao Tan, Wennan Zhao, Xiaoxue Xing, Yuling Qiu, Ran Wang, Meihua Jin, Guanwei Fan, Ping Zhang, Yuxu Zhong, Dexin Kong
Metastasis is the main cause of the lethality of prostate cancer. Class I phosphatidylinositol 3-kinases (PI3Ks), which contain 4 isoforms, α, β, δ, and γ, are known to play important roles in cell growth, migration, invasion, and so on. However, the respective role of each PI3K isoform in cancer cell migration and invasion remains unknown. In a study that aimed to elucidate the respective role of the 4 PI3K isoforms, we investigated the change in migratory and invasive ability of DU145 cells after treatment with each PI3K isoform-specific inhibitor...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29785056/genome-wide-mapping-reveals-that-deoxyuridine-is-enriched-in-the-human-centromeric-dna
#2
Xiaoting Shu, Menghao Liu, Zhike Lu, Chenxu Zhu, Haowei Meng, Sihao Huang, Xiaoxue Zhang, Chengqi Yi
Uracil in DNA can be generated by cytosine deamination or dUMP misincorporation; however, its distribution in the human genome is poorly understood. Here we present a selective labeling and pull-down technology for genome-wide uracil profiling and identify thousands of uracil peaks in three different human cell lines. Surprisingly, uracil is highly enriched at the centromere of the human genome. Using mass spectrometry, we demonstrate that human centromeric DNA contains a higher level of uracil. We also directly verify the presence of uracil within two centromeric uracil peaks on chromosomes 6 and 11...
May 21, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29781172/manganese-catalyzed-hydrosilylation-reactions
#3
Congyang Wang, Xiaoxu Yang
In the past few decades, manganese-catalyzed hydrosilylation of C=O or C=C/C≡C unsaturated bonds achieved enormous developments. In this focus review, the hydrosilylation reactions of alkene, alkyne and carbonyl-containing substrates catalyzed by manganese complexes, are summarized. Moreover, the mechanisms of manganese-catalyzed hydrosilylation are discussed briefly.
May 20, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29778422/sp1-induced-upregulation-of-lncrna-pandar-predicts-adverse-phenotypes-in-retinoblastoma-and-regulates-cell-growth-and-apoptosis-in-vitro-and-in-vivo
#4
Lijie Sheng, Jing Wu, Xuewu Gong, Duo Dong, Xiaoxue Sun
Retinoblastoma (RB) is an intraocular malignancy for children and has a high mortality rate. Long non-coding RNAs (lncRNAs) are emerging as gene regulators and biomarkers in various malignancies. PANDAR is a novel cancer-related lncRNA that dysregulated in several types of cancers. However, its clinical value and potential effects on RB remains unclear. RT-qPCR was used to assess the relative expression of PANDAR in RB tissues and cells. Additionally, chromatin immunoprecipitation (ChIP) and luciferase reporter assays were performed to investigate whether SP1 could bind to the promoter region of PANDAR and activate its transcription...
May 17, 2018: Gene
https://www.readbyqxmd.com/read/29778142/behaviors-and-kinetics-of-toluene-adsorption-desorption-on-activated-carbons-with-varying-pore-structure
#5
Xi Yang, Honghong Yi, Xiaolong Tang, Shunzheng Zhao, Zhongyu Yang, Yueqiang Ma, Tiecheng Feng, Xiaoxu Cui
This work was undertaken to investigate the behaviors and kinetics of toluene adsorption and desorption on activated carbons with varying pore structure. Five kinds of activated carbon from different raw materials were selected. Adsorption isotherms and breakthrough curves for toluene were measured. Langmuir and Freundlich equations were fitted to the equilibrium data, and the Freundlich equation was more suitable for simulating toluene adsorption. The process consisted of monolayer, multilayer and partial active site adsorption types...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778008/plasma-metabolic-changes-in-chinese-hiv-infected-patients-receiving-lopinavir-ritonavir-based-treatment-implications-for-hiv-precision-therapy
#6
Xiaolin Li, Tong Wu, Yongjun Jiang, Zining Zhang, Xiaoxu Han, Wenqing Geng, Haibo Ding, Jing Kang, Qi Wang, Hong Shang
OBJECTIVES: The goal of this study is to profile the metabolic changes in the plasma of HIV patients receiving lopinavir/ritonavir (LPV/r)-based highly active antiretroviral therapy (HAART) relative to their treatment-naïve phase, aimed to identify precision therapy for HIV for improving prognosis and predicting dyslipidemia caused by LPV/r. METHODS: 38 longitudinal plasma samples were collected from 19 HIV-infected patients both before and after antiretroviral therapy, and 18 samples from healthy individuals were used as controls...
May 16, 2018: Cytokine
https://www.readbyqxmd.com/read/29775417/targeting-histone-methyltransferase-enhancer-of-zeste-homolog-2-inhibits-renal-epithelial-mesenchymal-transition-and-attenuates-renal-fibrosis
#7
Xiaoxu Zhou, Chongxiang Xiong, Evelyn Tolbert, Ting C Zhao, George Bayliss, Shougang Zhuang
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial-mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 were highly expressed in mouse kidney with unilateral ureteral obstruction and cultured mouse kidney proximal tubular (TKPT) cells undergoing EMT. Inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) attenuated renal fibrosis, which was associated with preserving E-cadherin expression and inhibiting Vimentin up-regulation in the obstructed kidney...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29775111/tamoxifen-prevents-d-galactosamine-lipopolysaccharide-induced-murine-acute-hepatic-failure-through-inhibition-of-oxidative-stress-and-mmd-2-upregulation
#8
Xiaoxue Gong, Peng Cao, Liping Liu, Yan Lin, Qing Yang, Linyu Zhou, Tianen Wu, Mansheng Luo
Oxidative stress is considered one of the major mechanisms underlying lipopolysaccharide (LPS)-induced acute liver failure (ALF). Tamoxifen has been reported to ameliorate LPS-induced ALF via the induction of monocyte to macrophage differentiation-associated 2 (Mmd-2). Whether antioxidant effects are involved remains unknown. Mice were given tamoxifen (TAM) once a day for 3 days. Twelve hours later, d-galactosamine (GaIN) and LPS were injected intraperitoneally to induce ALF. N-Acetylcysteine (NAC) was administered immediately after ALF induction as a positive control...
May 18, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29772825/identification-and-characterization-of-the-wox-family-genes-in-five-solanaceae-species-reveal-their-conserved-roles-in-peptide-signaling
#9
Xiaoxu Li, Madiha Hamyat, Cheng Liu, Ahmad Salman, Xiaoming Gao, Cun Guo, Yuanying Wang, Yongfeng Guo
Members of the plant-specific WOX (WUSCHEL-related homeobox) transcription factor family have been reported to play important roles in peptide signaling that regulates stem cell maintenance and cell fate specification in various developmental processes. Even though remarkable advances have been made in studying WOX genes in Arabidopsis , little is known about this family in Solanaceae species. A total of 45 WOX members from five Solanaceae species were identified, including eight members from Solanum tuberosum , eight from Nicotiana tomentosiformis , 10 from Solanum lycopersicum , 10 from Nicotiana sylvestris and nine from Nicotiana tabacum ...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29772102/novel-nomograms-for-castration-resistant-prostate-cancer-and-survival-outcome-in-patients-with-de-novo-bone-metastatic-prostate-cancer
#10
Jinge Zhao, Guangxi Sun, Banghua Liao, Xingming Zhang, Cameron M Armstrong, Xiaoxue Yin, Jiandong Liu, Junru Chen, Yaojing Yang, Peng Zhao, Qidun Tang, Zhenghao Wang, Zhibin Chen, Xiong Li, Qiang Wei, Xiang Li, Ni Chen, Allen C Gao, Pengfei Shen, Hao Zeng
OBJECTIVES: To develop nomograms predicting the incidence of castration resistant prostate cancer (CRPC) and overall survival (OS) for de novo metastatic prostate cancer (mPCa). MATERIALS AND METHODS: Data from 449 de novo mPCa patients were retrospectively analyzed. Patients were randomly divided into the training (n=314, 70%) and validation cohort (n=135, 30%). Predictive factors were selected by Cox-proportional model and further used for building predictive models...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29771768/high-density-infiltration-of-v-domain-immunoglobulin-suppressor-of-t-cell-activation-up-regulated-immune-cells-in-human-pancreatic-cancer
#11
Jinʼe Liu, Xiaoxue Xie, Chunxiao Xuan, Tingting Li, Lanlan Wang, Lianghong Teng, Jun Liu
V-domain immunoglobulin suppressor of T-cell activation (VISTA) is constitutively expressed in hematopoietic lineage and is highly up-regulated in tumor infiltrated myeloid cells and regulatory T cells in animal models. However, its expression in human pancreatic tumor microenvironment remains unknown. In this research, we aimed at the expression of VISTA in human pancreatic cancer samples. METHODS: We performed immunohistochemistry to determine VISTA expression in human pancreatic cancer samples...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29766158/study-of-oxygen-evolution-reaction-on-amorphous-au-13-ni-120-p-50-nanocluster
#12
Yanzhou Wang, Panpan Gao, Xiaoxu Wang, Jinrong Huo, Lu Li, Yajing Zhang, Alex A Volinsky, Ping Qian, Yanjing Su
The pursuit of catalysts to promote effective water oxidization to produce oxygen has become a research subject of high priority for water splitting. Here, first-principles calculations are employed to study the water-splitting oxygen evolution reaction (OER) on ∼1.5 nm diameter Au13@Ni120P50 core-shell nanoclusters. Water splitting to produce oxygen proceeds in four intermediate reaction steps (OH*, O*, OOH* and O2). Adsorption configurations and adsorption energies for the species involved in OER on both Au13@Ni120P50 cluster and Ni12P5(001) supported by Au are presented...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29765506/6-o-galloylpaeoniflorin-attenuates-cerebral-ischemia-reperfusion-induced-neuroinflammation-and-oxidative-stress-via-pi3k-akt-nrf2-activation
#13
Zhongmei Wen, Weichen Hou, Wei Wu, Yang Zhao, Xuechao Dong, Xiaoxue Bai, Liping Peng, Lei Song
6'- O -galloylpaeoniflorin (GPF), a galloylated derivative of paeoniflorin isolated from peony root, has been proven to possess antioxidant potential. In this present study, we revealed that GPF treatment exerted significant neuroprotection of PC12 cells following OGD, as evidenced by a reduction of oxidative stress, inflammatory response, cellular injury, and apoptosis in vitro. Furthermore, treatment with GPF increased the levels of phosphorylated Akt (p-Akt) and nuclear factor-erythroid 2-related factor 2 (Nrf2), as well as promoted Nrf2 translocation in PC12 cells, which could be inhibited by Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29763432/distinctive-types-of-postzygotic-single-nucleotide-mosaicisms-in-healthy-individuals-revealed-by-genome-wide-profiling-of-multiple-organs
#14
August Yue Huang, Xiaoxu Yang, Sheng Wang, Xianing Zheng, Qixi Wu, Adam Yongxin Ye, Liping Wei
Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown. Using whole-genome sequencing and ultra-deep amplicon re-sequencing, we identified and validated 164 pSNMs from 27 postmortem organ samples obtained from five healthy donors. The mutant allele fractions ranged from 1.0% to 29.7%. Inter- and intra-organ comparison revealed two distinctive types of pSNMs, with about half originating during early embryogenesis (embryonic pSNMs) and the remaining more likely to result from clonal expansion events that had occurred more recently (clonal expansion pSNMs)...
May 15, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29758921/mineral-n-stock-and-nitrate-accumulation-in-the-50-to-200m-profile-on-the-loess-plateau
#15
Xiaoxu Jia, Yuanjun Zhu, Laiming Huang, Xiaorong Wei, Yunting Fang, Lianhai Wu, Andrew Binley, Mingan Shao
Nitrogen (N) stored in deep profiles is important in assessing regional and/or global N stocks and nitrate leaching risk to groundwater. The Chinese Loess Plateau, which is characterized by significantly thick loess deposits, potentially stores immense stocks of mineral N, posing future threats to groundwater quality. In order to determine the vertical distributions of nitrate and ammonium content in the region, as well as to characterize the potential accumulation of nitrate in the deep loess profile, we study loess samples collected at five sites (Yangling, Changwu, Fuxian, An'sai and Shenmu) through a 50 to 200m loess profile...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29758897/the-association-between-ambient-pm2-5-exposure-and-the-risk-of-preterm-birth-in-china-a-retrospective-cohort-study
#16
Tongjun Guo, Yuanyuan Wang, Hongguang Zhang, Ya Zhang, Jun Zhao, Qiaomei Wang, Haiping Shen, Yan Wang, Xiaoxu Xie, Long Wang, Zongyu Xu, Yiping Zhang, Donghai Yan, Yuan He, Ying Yang, Jihong Xu, Zuoqi Peng, Xu Ma
BACKGROUND: The relationship between PM2.5 exposure and preterm birth remains unclear. OBJECTIVES: To explore the effect of exposure to PM2.5 on preterm birth in China. METHODS: The birth outcomes of 426,246 pregnant women enrolled between January 2014 and December 2014 in NFPCP (National Free Pre-pregnancy Checkups Project) were collected, and their individual PM2.5 exposure values were estimated from the China National Environmental Monitoring Centre...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29742515/dose-response-between-cardiovascular-risk-factors-and-cardiovascular-mortality-among-incident-peritoneal-dialysis-patients
#17
Xiaoxue Zhang, Dahai Yu, Yamei Cai, Jin Shang, Rui Qin, Jing Xiao, Xing Tian, Zhanzheng Zhao, David Simmons
BACKGROUND/AIMS: Traditional cardiovascular (CV) risk factors (RFs) and their management targets may not be applicable to specific medical subpopulations, particularly dialysis patients. This study aimed to evaluate the dose-response association between measurements of RFs, cardiovascular mortality, and potential metabolic targets among Chinese patients initializing peritoneal dialysis (PD). METHODS: Risk-set sampling was applied to two population based 1: 10 case-control studies of incident PD patients, matched by age, sex and the year of initialisation of PD: a main sample (204 cases and 2,040 controls) and a replication sample (81 cases and 810 controls)...
April 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29735557/decomposing-gratitude-representation-and-integration-of-cognitive-antecedents-of-gratitude-in-the-brain
#18
Hongbo Yu, Xiaoxue Gao, Yuanyuan Zhou, Xiaolin Zhou
Gratitude is a typical social-moral emotion that plays a crucial role in maintaining human cooperative interpersonal relationship. Although neural correlates of gratitude have been investigated, the neurocognitive processes that lead to gratitude, namely the representation and integration of its cognitive antecedents, remain largely unknown. Here, we combined fMRI and a human social interaction task to investigate how benefactor's cost and beneficiary's benefit, two critical antecedents of gratitude, are encoded and integrated in beneficiary's brain, and how the neural processing of gratitude is converted to reciprocity...
May 7, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29735319/lipid-accumulation-of-chlorella-pyrenoidosa-under-mixotrophic-cultivation-using-acetate-and-ammonium
#19
Lijun Liu, Yuan Zhao, Xiaoxue Jiang, Xiaoyu Wang, Wenyan Liang
Acetate and ammonium were used as organic carbon and nitrogen sources, respectively, during mixotrophic cultivation of Chlorella pyrenoidosa. Cell growth, content of neutral lipid (NL), productivity of biomass and total lipid, and fatty acid profiles were investigated. Results showed that C. pyrenoidosa could endure high concentrations of NH4 + -N (100-200 mg/L) and immediately entered logarithmic growth, when the culture media contained 2.0-10.0 g/L NaAc. The 2.0-10.0 g/L NaAc in the media also resulted in the NL content of 1...
April 25, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29734764/simultaneous-mean-and-covariance-correction-filter-for-orbit-estimation
#20
Xiaoxu Wang, Quan Pan, Zhengtao Ding, Zhengya Ma
This paper proposes a novel filtering design, from a viewpoint of identification instead of the conventional nonlinear estimation schemes (NESs), to improve the performance of orbit state estimation for a space target. First, a nonlinear perturbation is viewed or modeled as an unknown input (UI) coupled with the orbit state, to avoid the intractable nonlinear perturbation integral (INPI) required by NESs. Then, a simultaneous mean and covariance correction filter (SMCCF), based on a two-stage expectation maximization (EM) framework, is proposed to simply and analytically fit or identify the first two moments (FTM) of the perturbation (viewed as UI), instead of directly computing such the INPI in NESs...
May 5, 2018: Sensors
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