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https://www.readbyqxmd.com/read/29017478/effectiveness-of-pulmonary-rehabilitation-in-patients-with-interstitial-lung-disease-of-different-etiology-a-multicenter-prospective-study
#1
Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti, Enrico M Clini
BACKGROUND: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. METHODS: Forty-one patients (IPF 63%, age 66...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28894957/efficacy-of-a%C3%A2-multidisciplinary-pulmonary-rehabilitation-outpatient-program-on-exacerbations-in-overweight-and-obese-patients-with-asthma
#2
Ipek Candemir, Pinar Ergun, Dicle Kaymaz
BACKGROUND: Even though many studies have investigated the effectiveness of weight loss interventions, the efficacy of pulmonary rehabilitation (PR) has not yet been proven in obese patients with asthma. The aims of this study were to investigate the efficacy of PR on asthma exacerbations in the first year after PR and to evaluate the efficacy of PR in exercise capacity, quality of life, psychosocial symptoms and control of asthma in overweight patients. METHODS: The exercise capacity, health-related quality of life scores, psychosocial symptoms, asthma control test (ACT) data, number of emergency admissions and hospitalizations of 35 overweight patients with asthma who completed a 1-year multidisciplinary PR program were recorded and analyzed...
October 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28807137/association-of-anxiety-sensitivity-physical-concerns-and-fvc-with-dyspnea-severity-in-sarcoidosis
#3
Pawel Holas, Julia Szymańska, Anna Dubaniewicz, Małgorzata Farnik, Agnieszka Jarzemska, Izabela Krejtz, Marta Maskey-Warzechowska, Joanna Domagala-Kulawik
OBJECTIVE: The purpose of the study was to evaluate the relationship of an objective functional lung parameter (FVC) and a subjective psychological factor (physical symptom concerns) with dyspnea in sarcoidosis. Dyspnea constitutes one of the most common and burdensome symptoms in sarcoidosis, yet little is known about its mechanisms and, in particular, psychological. METHOD: A total of 107 hospitalized sarcoidosis patients (Female=50, Mage=45.3years) volunteered to take part in the correlational research study...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28790815/development-of-the-propal-copd-tool-to-identify-patients-with-copd-for-proactive-palliative-care
#4
R G Duenk, C Verhagen, E M Bronkhorst, R S Djamin, G J Bosman, E Lammers, Pnr Dekhuijzen, Kcp Vissers, Y Engels, Y Heijdra
BACKGROUND: Our objective was to develop a tool to identify patients with COPD for proactive palliative care. Since palliative care needs increase during the disease course of COPD, the prediction of mortality within 1 year, measured during hospitalizations for acute exacerbation COPD (AECOPD), was used as a proxy for the need of proactive palliative care. PATIENTS AND METHODS: Patients were recruited from three general hospitals in the Netherlands in 2014. Data of 11 potential predictors, a priori selected based on literature, were collected during hospitalization for AECOPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28717742/simplified-graded-baseline-symptom-assessment-in-patients-with-lung-cancer-undergoing-first-line-chemotherapy-correlations-and-prognostic-role-in-a-resource-constrained-setting
#5
Potsangbam Sarat Singh, Ashutosh Nath Aggarwal, Digambar Behera, Rakesh Kapoor, Navneet Singh
PURPOSE: There are limited data from developing countries on graded baseline symptom (BS) assessment in lung cancer. This prospective study aimed to assess the prognostic role of BS and correlation of BS with comorbidity, demographic, and investigation profiles in a cohort of 238 patients with lung cancer undergoing first-line chemotherapy over a 15-month period. METHODS: The Medical Research Council (MRC) scale was used to assess dyspnea, whereas the visual analog scale (VAS; score of 1 to 10) was used to assess anorexia, fatigue, chest pain, and cough...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28618190/relation-between-upper-limb-muscle-strength-with-exercise-capacity-quality-of-life-and-dyspnea-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#6
Dicle Kaymaz, İpek Çaylı Candemir, Pınar Ergün, Neşe Demir, Filiz Taşdemir, Pervin Demir
INTRODUCTION: In chronic obstructive pulmonary disease (COPD), skeletal muscle weakness is characterized by reduced muscle strength, reduced muscle endurance and the presence of muscle fatigue especially in lower limbs. There has been little research into the upper limb skeletal muscles. OBJECTIVES: In this study, we aimed to investigate the relation of upper limb muscle strength with pulmonary function, exercise capacity, quality of life (QoL) and dyspnea sensation...
June 15, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28615932/expanding-the-inspired-copd-outreach-program%C3%A2-to-the-emergency-department-a-feasibility-assessment
#7
Darcy Gillis, Jillian Demmons, Graeme Rocker
BACKGROUND: The Halifax-based INSPIRED COPD Outreach Program™ is a facility-to-community home-based novel clinical initiative that through improved care transitions, self-management, and engagement in advance care planning has demonstrated a significant (60%-80%) reduction in health care utilization with substantial cost aversion. By assessing the feasibility of expanding INSPIRED into the emergency department (ED) we anticipated extending reach and potential for positive impact of INSPIRED to those with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) who avoid hospital admission...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28609770/fatigue-and-excessive-daytime-sleepiness-in-sarcoidosis-prevalence-predictors-and-relationships-between-the-two-symptoms
#8
Andrea Bosse-Henck, Rainer Koch, Hubert Wirtz, Andreas Hinz
BACKGROUND: Fatigue is common among patients with sarcoidosis. The etiology of this problem is unknown and multifactorial. Fatigue can be confounded with excessive daytime sleepiness (EDS). Fatigue and sleepiness have rarely been studied simultaneously in sarcoidosis patients. OBJECTIVES: The aim of this study was the confounder-adjusted estimation of risks for severe fatigue and EDS in a large population of sarcoidosis patients and the development of multivariate predictors from this population...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28566268/high-level-of-integration-in-integrated-disease-management-leads-to-higher-usage-in-the-e-vita-study-self-management-of-chronic-obstructive-pulmonary-disease-with-web-based-platforms-in-a-parallel-cohort-design
#9
Esther Pwa Talboom-Kamp, Noortje A Verdijk, Marise J Kasteleyn, Lara M Harmans, Irvin Jsh Talboom, Mattijs E Numans, Niels H Chavannes
BACKGROUND: Worldwide, nearly 3 million people die of chronic obstructive pulmonary disease (COPD) every year. Integrated disease management (IDM) improves disease-specific quality of life and exercise capacity for people with COPD, but can also reduce hospital admissions and hospital days. Self-management of COPD through eHealth interventions has shown to be an effective method to improve the quality and efficiency of IDM in several settings, but it remains unknown which factors influence usage of eHealth and change in behavior of patients...
May 31, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28152797/identifying-tools-for-capturing-the-overall-experience-of-dyspnea-in-a-lung-cancer-population-the-patient-s-perspective
#10
Aixin Liu, Brandon Chan, Brandon Tsui, Elizabeth Hall, Lauren Wong, Mindy Liang, Samantha Sarabia, Sabrina Yeung, Andrea Perez-Cosio, Catherine Brown, Yvonne Leung, Doris Howell, Geoffrey Liu
73 Background: Efficient methods of tracking dyspnea can improve quality of care. We asked lung cancer patients to assess five validated patient-reported outcome (PRO) tools and determine whether these tools captured different domains of their dyspnea experience. METHODS: This cross-sectional study of adult lung cancer outpatients of all stages utilized touch screen tablets to administer five dyspnea tools (Borg severity (B), Reduced Cancer Dyspnea (R), Breathlessness intensity (I), breathlessness distress (D), and MRC breathlessness (M) scales) that focused on the severity, experience, intensity, extent, and functional impairment of dyspnea, respectively...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27858160/assessing-the-therapeutic-response-to-pirfenidone-in-idiopathic-pulmonary-fibrosis-can-we-do-better-than-with-forced-vital-capacity-alone
#11
Karishma Hosein, Jamie Le, Marco Mura
New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic Index-CPI; gender-age-physiology-GAP; risk stratification score-RISE) would better capture response to therapy. In this pilot study, treated and untreated cohorts of IPF patients, matched for demographic and functional characteristics were prospectively followed for 1 year, at 4-month intervals...
February 2017: Lung
https://www.readbyqxmd.com/read/27818328/clinical-features-of-smokers-with-radiological-emphysema-but-without-airway-limitation
#12
Ana B Alcaide, Pablo Sanchez-Salcedo, Gorka Bastarrika, Arantza Campo, Juan Berto, Maria Del Mar Ocon, Alejandro Fernandez-Montero, Bartolome R Celli, Javier J Zulueta, Juan P de-Torres
BACKGROUND: The clinical characteristics of patients with emphysema but without airway limitations remain unknown. The goal of this study was to compare the clinical features of current and former smokers without airflow limitation who have radiologic emphysema on chest CT scans vs a control group of current and ex-smokers without emphysema. METHODS: Subjects enrolled had anthropometric characteristics recorded, provided a medical history, and underwent low-dose chest CT scanning...
February 2017: Chest
https://www.readbyqxmd.com/read/27692130/factors-associated-with-pulmonary-hypertension-and-long-term-survival-in-bronchiectasis-subjects
#13
Serpil Öcal, Oytun Portakal, Arslan Öcal, Ahmet Uğur Demir, Arzu Topeli, Lütfi Çöplü
BACKGROUND: The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS: We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. RESULTS: Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27614218/characterization-of-serological-neo-epitope-biomarkers-reflecting-collagen-remodeling-in-clinically-stable-chronic-obstructive-pulmonary-disease
#14
Jannie M B Sand, Gerd Martinez, Anne-Kirsten Midjord, Morten A Karsdal, Diana J Leeming, Peter Lange
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation that leads to excessive remodeling of the lung extracellular matrix (ECM), resulting in release of protein fragments (neo-epitopes) to the blood. Serological markers assessing this have previously been associated with exacerbations of COPD. However, characterization of these in individuals with clinically stable COPD is lacking. The aim of this study was to characterize the collagen remodeling in stable COPD by the serological assessment of neo-epitopes...
October 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27578574/-inspiratory-muscle-training-followed-by-non-invasive-positive-pressure-ventilation-in-patients-with-severe-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Lu-Qian Zhou, Xiao-Ying Li, Yun Li, Bing-Peng Guo, Li-Li Guan, Xin Chen, Yu-Wen Luo, Peng Luo, Rong-Chang Chen
OBJECTIVE: To investigate the effects of inspiratory muscle training followed by non-invasive positive pressure ventilation in patients with severe chronic obstructive pulmonary disease (COPD). METHODS: This investigator-initiated randomized, controlled trial recruited 88 patients with stable GOLD stage IV COPD, who were randomized into 4 equal groups to continue oxygen therapy (control group) or to receive inspiratory muscle training followed by non-invasive positive pressure ventilation (IMT-NPPV group), inspiratory muscle training only (IMT group), or noninvasive positive pressure ventilation only (NPPV group) for at least 8 weeks...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27457828/identifying-patients-at-higher-risk-of-prolonged-air%C3%A2-leak-after-lung-resection
#16
Sebastien Gilbert, Sonam Maghera, Andrew J Seely, Donna E Maziak, Farid M Shamji, Sudhir R Sundaresan, Patrick J Villeneuve
BACKGROUND: Predictive models of prolonged air leak have relied on information not always available preoperatively (eg, extent of resection, pleural adhesions). Our objective was to construct a model to identify patients at increased risk of prolonged air leak using preoperative factors exclusively. METHODS: From 2012 to 2014, data on consecutive patients undergoing pulmonary resection were collected prospectively. Prolonged air leak was defined as lasting longer than 7 days and requiring hospitalization...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27451589/respiratory-rehabilitation-in-healing-depression-and-anxiety-in-copd-patients
#17
Maria-Mădălina Bodescu, Adina Magdalena Turcanu, Maria-Cristina Gavrilescu, T Mihăescu
UNLABELLED: Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory affection of the whole lung, characterized by an accelerated loss of the pulmonary functions, that reduces the patients' independence and stops them from having a normal, active life. The medical rehabilitation is considered "Third class rehabilitation", after preventive medicine and pharmaceutical medicine, and the respiratory rehabilitation recovery represents a complex structure of service addressing to patients with chronic pulmonary illnesses whose aim is to optimize the physical performances, psycho-social and autonomy...
October 2015: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/27262226/determinants-of-smoking-cessation-in-patients-with-copd-treated-in-the-outpatient-setting
#18
Sandra S Tøttenborg, Reimar W Thomsen, Søren P Johnsen, Henrik Nielsen, Peter Lange
BACKGROUND: The beneficial effects of smoking cessation on the progression of COPD are well established. Nevertheless, many patients with COPD continue to smoke. METHODS: In this nationwide hospital-based prospective follow-up study, we examined rates of smoking cessation and clinical and sociodemographic determinants of smoking cessation in 3,233 patients with COPD who smoked on outpatient contact during 2008 to 2012. Using multivariate Cox regression, we calculated hazard ratios (HRs) of quitting...
September 2016: Chest
https://www.readbyqxmd.com/read/26932809/factors-associated-with-depression-in-copd-a-multicenter-study
#19
Carlos Martinez Rivera, Joaquín Costan Galicia, Bernardino Alcázar Navarrete, Cayo Garcia-Polo, Luis Alberto Ruiz Iturriaga, Alberto Herrejón, Jose Antonio Ros Lucas, Patricia García-Sidro, Gema Tirado-Conde, Jose Luis López-Campos, Sagrario Mayoralas Alises, Javier de Miguel-Díez, Cristina Esquinas, Marc Miravitlles
INTRODUCTION: Depression is a prevalent comorbidity in COPD and has an impact on the prognosis of these patients, thereby making it important to study the factors associated with depression in patients with COPD. METHOD: A multicenter, observational and cross-sectional study was conducted to study the factors associated with depression in patients with COPD measured by the hospital anxiety and depression (HAD) questionnaire. We analyzed anthropometric variables and the number of exacerbations in the previous year and calculated the 6-min walking test and the body mass index, airflow obstruction, dyspnea, and exercise (BODE) index...
June 2016: Lung
https://www.readbyqxmd.com/read/26684748/fasting-glucose-levels-correlate-with-disease-severity-of-guillain-barr%C3%A3-syndrome
#20
Ying Wang, Guihong Li, Siyu Yang, Xiaoyi Gu, Xinyu Li, Mingyang Liu, Xiujuan Wu, Yun Guan, Rayomand Press, Jie Zhu, Hong-Liang Zhang
OBJECTIVE: A potential association between diabetes and Guillain-Barré syndrome (GBS) has been indicated by a few case studies. We retrospectively analyzed the clinical features of a large cohort of GBS patients to explore the relationship between the level of fasting plasma glucose (FPG) obtained in the acute phase at admission and the severity of GBS. METHODS: Three hundred and four GBS patients were divided into two groups, one with normal FPG and the other with high FPG levels according to the international standards of FPG...
2015: PloS One
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