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https://www.readbyqxmd.com/read/27858160/assessing-the-therapeutic-response-to-pirfenidone-in-idiopathic-pulmonary-fibrosis-can-we-do-better-than-with-forced-vital-capacity-alone
#1
Karishma Hosein, Jamie Le, Marco Mura
New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic Index-CPI; gender-age-physiology-GAP; risk stratification score-RISE) would better capture response to therapy. In this pilot study, treated and untreated cohorts of IPF patients, matched for demographic and functional characteristics were prospectively followed for 1 year, at 4-month intervals...
November 17, 2016: Lung
https://www.readbyqxmd.com/read/27818328/clinical-features-of-smokers-with-radiological-emphysema-but-without-airway-limitation
#2
Ana B Alcaide, Pablo Sanchez, Gorka Bastarrika, Arantza Campo, Juan Berto, Maria Del Mar Ocon, Bartolome R Celli, Javier J Zulueta, Juan P de-Torres
RATIONALE: The clinical characteristics of patients with emphysema but without airway limitation remain unknown. OBJECTIVE: To compare the clinical features of current and former smokers without airflow limitation who have radiological emphysema on chest CT with a control group of current and ex-smokers without emphysema. METHODS: Subjects enrolled had anthropometrics, medical history and a low dose chest computed tomography (LDCT). The following parameters were also evaluated: pulmonary function tests (PFT) including diffusion capacity for carbon monoxide (DLCO), modified MRC dyspnea score, COPD assessment test (CAT) and 6-min walk distance (6MWD)...
November 3, 2016: Chest
https://www.readbyqxmd.com/read/27692130/factors-associated-with-pulmonary-hypertension-and-long-term-survival-in-bronchiectasis-subjects
#3
Serpil Öcal, Oytun Portakal, Arslan Öcal, Ahmet Uğur Demir, Arzu Topeli, Lütfi Çöplü
BACKGROUND: The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS: We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. RESULTS: Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27614218/characterization-of-serological-neo-epitope-biomarkers-reflecting-collagen-remodeling-in-clinically-stable-chronic-obstructive-pulmonary-disease
#4
Jannie M B Sand, Gerd Martinez, Anne-Kirsten Midjord, Morten A Karsdal, Diana J Leeming, Peter Lange
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation that leads to excessive remodeling of the lung extracellular matrix (ECM), resulting in release of protein fragments (neo-epitopes) to the blood. Serological markers assessing this have previously been associated with exacerbations of COPD. However, characterization of these in individuals with clinically stable COPD is lacking. The aim of this study was to characterize the collagen remodeling in stable COPD by the serological assessment of neo-epitopes...
October 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27578574/-inspiratory-muscle-training-followed-by-non-invasive-positive-pressure-ventilation-in-patients-with-severe-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#5
Lu-Qian Zhou, Xiao-Ying Li, Yun Li, Bing-Peng Guo, Li-Li Guan, Xin Chen, Yu-Wen Luo, Peng Luo, Rong-Chang Chen
OBJECTIVE: To investigate the effects of inspiratory muscle training followed by non-invasive positive pressure ventilation in patients with severe chronic obstructive pulmonary disease (COPD). METHODS: This investigator-initiated randomized, controlled trial recruited 88 patients with stable GOLD stage IV COPD, who were randomized into 4 equal groups to continue oxygen therapy (control group) or to receive inspiratory muscle training followed by non-invasive positive pressure ventilation (IMT-NPPV group), inspiratory muscle training only (IMT group), or noninvasive positive pressure ventilation only (NPPV group) for at least 8 weeks...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27457828/identifying-patients-at-higher-risk-of-prolonged-air%C3%A2-leak-after-lung-resection
#6
Sebastien Gilbert, Sonam Maghera, Andrew J Seely, Donna E Maziak, Farid M Shamji, Sudhir R Sundaresan, Patrick J Villeneuve
BACKGROUND: Predictive models of prolonged air leak have relied on information not always available preoperatively (eg, extent of resection, pleural adhesions). Our objective was to construct a model to identify patients at increased risk of prolonged air leak using preoperative factors exclusively. METHODS: From 2012 to 2014, data on consecutive patients undergoing pulmonary resection were collected prospectively. Prolonged air leak was defined as lasting longer than 7 days and requiring hospitalization...
July 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27451589/respiratory-rehabilitation-in-healing-depression-and-anxiety-in-copd-patients
#7
Maria-Mădălina Bodescu, Adina Magdalena Turcanu, Maria-Cristina Gavrilescu, T Mihăescu
UNLABELLED: Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory affection of the whole lung, characterized by an accelerated loss of the pulmonary functions, that reduces the patients' independence and stops them from having a normal, active life. The medical rehabilitation is considered "Third class rehabilitation", after preventive medicine and pharmaceutical medicine, and the respiratory rehabilitation recovery represents a complex structure of service addressing to patients with chronic pulmonary illnesses whose aim is to optimize the physical performances, psycho-social and autonomy...
October 2015: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/27262226/determinants-of-smoking-cessation-in-patients-with-copd-treated-in-the-outpatient-setting
#8
Sandra S Tøttenborg, Reimar W Thomsen, Søren P Johnsen, Henrik Nielsen, Peter Lange
BACKGROUND: The beneficial effects of smoking cessation on the progression of COPD are well established. Nevertheless, many patients with COPD continue to smoke. METHODS: In this nationwide hospital-based prospective follow-up study, we examined rates of smoking cessation and clinical and sociodemographic determinants of smoking cessation in 3,233 patients with COPD who smoked on outpatient contact during 2008 to 2012. Using multivariate Cox regression, we calculated hazard ratios (HRs) of quitting...
September 2016: Chest
https://www.readbyqxmd.com/read/26932809/factors-associated-with-depression-in-copd-a-multicenter-study
#9
Carlos Martinez Rivera, Joaquín Costan Galicia, Bernardino Alcázar Navarrete, Cayo Garcia-Polo, Luis Alberto Ruiz Iturriaga, Alberto Herrejón, Jose Antonio Ros Lucas, Patricia García-Sidro, Gema Tirado-Conde, Jose Luis López-Campos, Sagrario Mayoralas Alises, Javier de Miguel-Díez, Cristina Esquinas, Marc Miravitlles
INTRODUCTION: Depression is a prevalent comorbidity in COPD and has an impact on the prognosis of these patients, thereby making it important to study the factors associated with depression in patients with COPD. METHOD: A multicenter, observational and cross-sectional study was conducted to study the factors associated with depression in patients with COPD measured by the hospital anxiety and depression (HAD) questionnaire. We analyzed anthropometric variables and the number of exacerbations in the previous year and calculated the 6-min walking test and the body mass index, airflow obstruction, dyspnea, and exercise (BODE) index...
June 2016: Lung
https://www.readbyqxmd.com/read/26684748/fasting-glucose-levels-correlate-with-disease-severity-of-guillain-barr%C3%A3-syndrome
#10
Ying Wang, Guihong Li, Siyu Yang, Xiaoyi Gu, Xinyu Li, Mingyang Liu, Xiujuan Wu, Yun Guan, Rayomand Press, Jie Zhu, Hong-Liang Zhang
OBJECTIVE: A potential association between diabetes and Guillain-Barré syndrome (GBS) has been indicated by a few case studies. We retrospectively analyzed the clinical features of a large cohort of GBS patients to explore the relationship between the level of fasting plasma glucose (FPG) obtained in the acute phase at admission and the severity of GBS. METHODS: Three hundred and four GBS patients were divided into two groups, one with normal FPG and the other with high FPG levels according to the international standards of FPG...
2015: PloS One
https://www.readbyqxmd.com/read/26647416/erectile-dysfunction-in-copd-patients
#11
Onur Turan, Iyimser Ure, Pakize Ayse Turan
Sexual dysfunction is a common problem in chronic obstructive pulmonary disease (COPD). We aimed to assess the presence of erectile dysfunction (ED) in COPD patients. Ninety-three outpatients who had been diagnosed as COPD and followed in Bolvadin State Hospital, Afyon, Turkey, were included in the study. All patients underwent pulmonary function tests and arterial blood gas analysis. They completed International Physical Activity Questionnaire (IPAQ), Medical Research Council (MRC) Dyspnea Scale, Short Form 36-item Scale (SF-36), and International Index of Erectile Function (IIEF) Questionnaire...
February 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/26628761/outcomes-associated-with-acute-exacerbations-of-chronic-obstructive-pulmonary-disorder-requiring-hospitalization
#12
Gajanan S Gaude, B P Rajesh, Alisha Chaudhury, Jyothi Hattiholi
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disorder (AECOPD) are known to be associated with increased morbidity and mortality and have a significant socioeconomic impact. The factors that determine frequent hospital readmissions for AECOPD are poorly understood. The present study was done to ascertain failures rates following AECOPD and to evaluate factors associated with frequent readmissions. MATERIALS AND METHODS: We conducted a prospective study among 186 patients with COPD with one or more admissions for acute exacerbations in a tertiary care hospital...
September 2015: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/26572740/characteristics-disease-burden-and-costs-of-copd-patients-in-the-two-years-following-initiation-of-long-acting-bronchodilators-in-uk-primary-care
#13
Yogesh Suresh Punekar, Sarah H Landis, Keele Wurst, Hoa Le
BACKGROUND: To assess the symptomatic and cost burden among patients initiating long-acting bronchodilator (LABD) therapy and impact of adherence on healthcare resource use and costs. METHODS: This retrospective cohort study identified patients with COPD who were newly prescribed a LABD (long-acting muscarinic antagonist [LAMA], long-acting beta2-agonist [LABA], a combination of LABA+LAMA or combination of LABA with inhaled corticosteroid [ICS]/LABA) between January 1, 2009 and November 30, 2013 from the UK Clinical Practice Research Datalink...
November 16, 2015: Respiratory Research
https://www.readbyqxmd.com/read/26523899/-pulmonary-rehabilitation-efficiency-in-copd-patients-with-pulmonary-hypertension
#14
İpek Candemir, Pınar Ergün, Dicle Kaymaz, Neşe Demir, Cennet Filiz Taşdemir, Nurcan Egesel, Fatma Şengül
INTRODUCTION: COPD is among the most common causes for secondary pulmonary hypertension (PH). Pulmonary rehabilitation (PR) is recommended in the standard treatment of COPD. In this study, efficiency of multidisciplinary PR in COPD patients with PH was examined. PATIENTS AND METHODS: 88 patients stable COPD patients who applied to our center between 2008-2013 were enrolled. Un-likely PH patients were grouped as Group 1 while possible and likely PH cases were accepted as Group 2...
September 2015: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/26347843/successful-treatment-of-bulla-with-endobronchial-valves
#15
Erdoğan Çetinkaya, Mehmet Akif Özgül, Şule Gül, Hilal Boyacı, Ertan Cam, Emine Kamiloglu, Mustafa Çörtük
Emphysematous bullae are a complication of end-stage COPD. Patients with large bullae and poor respiratory function have limited treatment options. Surgical resection is a recognized treatment, but functional improvement after bullectomy is not satisfactory in patients with forced expiratory volume in 1 s (FEV1) < 35% predicted. When this 59-year-old male end-stage COPD patient was assessed, he was cachectic and lung function tests showed a FEV1 of 0.56 L (19% predicted) and a RV of 7 L (314% predicted), while 6MWT was 315 m and MRC dyspnea score was 4...
2015: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/26345817/impact-of-adherence-to-gold-guidelines-on-6-minute-walk-distance-mrc-dyspnea-scale-score-lung-function-decline-quality-of-life-and-quality-adjusted-life-years-in-a-shanghai-suburb
#16
RANDOMIZED CONTROLLED TRIAL
Y Q Jiang, Y X Zhu, X L Chen, X Xu, F Li, H J Fu, C Y Shen, Y Y Lu, Q J Zhuang, G Xu, Y Y Cai, Y Zhang, S S Liu, M Y Zhu, S H Li
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructive pulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary function, QOL, quality-adjusted life years (QALY), Medical Research Council (MRC) dyspnea scale, 6-min walk distance (6-MWD), number of emergency visits, and frequency of hospitalization...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26237356/does-physical-training-reduce-fatigue-in-sarcoidosis
#17
Rik Marcellis, Melanie Van der Veeke, Ilse Mesters, Marjolein Drent, Rob De Bie, Geeuwke De Vries, Antoine Lenssen
BACKGROUND: Sarcoidosis patients frequently experience fatigue, exercise intolerance and muscle weakness, resulting in reduced quality of life (QOL). Scientific studies on the benefits of physical training in sarcoidosis have been scarce, so the aim of this pilot study was to examine the impact of a 13-week physical training program on fatigue, physical functions and QOL in fatigued sarcoidosis patients and/or patients with exercise intolerance. METHODS: 18 sarcoidosis patients participated in a 13-week physical training program...
2015: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/26149089/evaluation-of-the-visit-frequency-and-the-use-of-questionnaires-and-indices-for-copd-a-national-survey-from-the-on-sint-study
#18
Cecilia López Ramírez, Carmen Calero Acuña, Cristina Represas Represas, Luz Aballe Santos, Ricard Casamor, Alberto Fernández-Villar, José Luis López-Campos
INTRODUCTION: Despite widespread recommendations to use standardized questionnaires and multidimensional indices for the assessment of patients with chronic obstructive pulmonary disease (COPD), few data are available on the application of these tools in clinical practice. This study evaluates the attitude of physicians participating in the On-Sint cohort toward the use of health status questionnaires and multidimensional indices, as well as toward the frequency of visits and spirometry in primary care and specialized care...
July 6, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26086595/patients-with-active-luminal-crohn-s-disease-have-evidence-of-significant-functional-and-clinical-pulmonary-involvement
#19
Farhad Peerani, May Choi, Justin Weinkauf, Richard N Fedorak, Brendan Halloran
BACKGROUND: Pulmonary involvement is a recognized extraintestinal complication of inflammatory bowel disease and is associated with airway inflammation. Changes in pulmonary function were previously described as being subclinical. The purpose of this study was to compare pulmonary findings in a large case series of patients with active and quiescent Crohn's disease (CD). METHODS: CD patients, prospectively enrolled between May 2011 and May 2012, completed a demographic questionnaire and Harvey-Bradshaw Index to define disease activity...
August 2015: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26064045/evaluation-of-the-copd-assessment-test-and-gold-patient-types-a-cross-sectional-analysis
#20
Jose Luis Lopez-Campos, Alberto Fernandez-Villar, Carmen Calero-Acuña, Cristina Represas-Represas, Cecilia Lopez-Ramírez, Virginia Leiro Fernández, Juan Jose Soler-Cataluña, Ricard Casamor
BACKGROUND: The COPD Assessment Test (CAT) has been recently developed to quantify COPD impact in routine practice. However, no relationship with other measures in the Global Initiative for Obstructive Lung Disease (GOLD) strategy has been evaluated. The present study aimed to evaluate the relationship of the CAT with other GOLD multidimensional axes, patient types, and the number of comorbidities. METHODS: This was a cross-sectional analysis of the Clinical presentation, diagnosis, and course of chronic obstructive pulmonary disease (On-Sint) study...
2015: International Journal of Chronic Obstructive Pulmonary Disease
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