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isolated systolic hypertension

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https://www.readbyqxmd.com/read/29306544/altered-left-ventricular-geometry-and-torsional-mechanics-in-high-altitude-induced-pulmonary-hypertension-a-three-dimensional-echocardiographic-study
#1
Bart W De Boeck, Aurel Toma, Stephanie Kiencke, Christoph Dehnert, Stefanie Zügel, Christoph Siebenmann, Katja Auinger, Peter T Buser, Marco Maggiorini, Beat A Kaufmann
BACKGROUND: Changes in left ventricular (LV) torsion have been related to LV geometry in patients with concomitant long-standing myocardial disease or pulmonary hypertension (PH). We evaluated the effect of acute high altitude-induced isolated PH on LV geometry, volumes, systolic function, and torsional mechanics. METHODS: Twenty-three volunteers were prospectively studied at low altitude and after the second (D3) and third night (D4) at high altitude (4,559 m)...
January 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29298567/sodium-excretion-and-associated-factors-in-urine-samples-of-african-descendants-in-alc%C3%A3-ntara-brazil-a-population-based-study
#2
Elisângela Milhomem Dos Santos, Dyego José de Araújo Brito, Isabela Leal Calado, Ana Karina Teixeira França, Joyce Santos Lages, Francisco das Chagas Monteiro Junior, Alcione Miranda Dos Santos, Natalino Salgado Filho
In most countries, salt intake has been excessive and constitutes one of the main risk factors for disease development, especially hypertension. Factors such as age, gender, sedentary lifestyle, smoking, African descent, obesity, dietary habits and family history of hypertension may be associated with high blood pressure. Studies show a positive association between the excretion of sodium and increased blood pressure. We evaluated the urinary excretion of sodium and associated factors in isolated urine samples of African descendants from remaining Quilombos...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29212831/impaired-pulmonary-arterial-vasoconstriction-and-nitric-oxide-mediated-relaxation-underlie-severe-pulmonary-hypertension-in-sugen-hypoxia-rat-model
#3
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia Filatava, Jun Li, Minglin Zhu, Jose Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas, Raouf A Khalil
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton's Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#4
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29191730/clinical-outcome-of-isolated-tricuspid-regurgitation-in-patients-with-preserved-left%C3%A2-ventricular-ejection-fraction-and-pulmonary%C3%A2-hypertension
#5
Nir Bar, Lorin Arie Schwartz, Simon Biner, Galit Aviram, Meirav Ingbir, Ido Nachmany, Gilad Margolis, Ben Sadeh, Rami Barashi, Gad Keren, Yan Topilsky
BACKGROUND: The outcome of tricuspid regurgitation (TR) remains unclear because of heterogeneity of etiology and the contradictory results of outcome studies. The aim of this study was to evaluate the clinical outcomes of TR in patients with pulmonary hypertension (PH) and normal left systolic function, stratified to patients with post- or precapillary PH. METHODS: In patients with no left valvar disease (isolated) functional TR, preserved left systolic function (ejection fraction ≥ 50%), and PH (systolic pulmonary pressure > 50 mm Hg), TR was assessed both qualitatively (grade) and semiquantitatively using the vena contracta method, and retrospective analysis of long-term outcomes was conducted...
November 28, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29178567/prognostic-markers-in-congenital-diaphragmatic-hernia-left-ventricular-diameter-and-pulmonary-hypertension
#6
Derya Karpuz, Dilek Giray, Yalcin Celik, Olgu Hallioglu
BACKGROUND: The aim of the study is to predict prognosis of newborns with congenital diaphragmatic hernia (CDH) with the left ventricular diameter and estimated pulmonary artery pressure values. METHODS: Patients in the newborn unit in 2012-2016 were screened retrospectively. Echocardiographic measurements of 35 patients with isolated left lateral CDH and 25 healthy newborn were compared in the first 24h of life. RESULTS: The mean values ​​of left ventricular end-diastolic (LVEDD) and end-systolic (LVESD) diameters, and ejection fraction were significantly lower in the patients...
November 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29176890/persistent-abnormalities-in-pulmonary-arterial-compliance-after-heart-transplantation-in-patients-with-combined-post-capillary-and-pre-capillary-pulmonary-hypertension
#7
Stefano Ghio, Gabriele Crimi, Silvia Pica, Pier Luigi Temporelli, Massimo Boffini, Mauro Rinaldi, Claudia Raineri, Laura Scelsi, Massimo Pistono, Rossana Totaro, Stefania Guida, Luigi Oltrona Visconti
BACKGROUND: The hemodynamic definitions of pulmonary hypertension (PH) in left heart disease have recently been refined to better match the characteristics required to reflect the presence of pulmonary vascular disease. Accordingly, we tested the hypothesis that abnormalities in the stiffness of pulmonary circulation would persist after heart transplantation in patients with combined post-capillary and pre-capillary PH (Cpc-PH) in contrast to those with isolated post-capillary PH (Ipc-PH)...
2017: PloS One
https://www.readbyqxmd.com/read/29151830/antihypertensive-properties-of-tilapia-oreochromis-spp-frame-and-skin-enzymatic-protein-hydrolysates
#8
Hsin-Chieh Lin, Adeola M Alashi, Rotimi E Aluko, Bonnie Sun Pan, Yu-Wei Chang
Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein isolates (FPI and SPI). The most active hydrolysate was then tested for blood pressure-lowering ability in spontaneously hypertensive rats (SHRs). Tilapia frame and skin protein hydrolysates (FPHs and SPHs) were respectively produced from FPI and SPI hydrolysis using pepsin, papain, or bromelain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29151278/tetrahydrobiopterin-bh4-targeting-endothelial-nitric-oxide-synthase-as-a-potential-therapy-for-pulmonary-hypertension
#9
Bahaa N Francis, Maram Salameh, Rola Khamisy-Farah, Raymond Farah
PURPOSE: Pulmonary Hypertension (PH) is complex disease which is associated with endothelial and cardiac dysfunction. Tetrahydrobiopterin (BH4 ) regulates endothelial nitric oxide synthase (eNOS) to produce nitric oxide rather than superoxide which maintains normal endothelial and cardiac function. This study explores the therapeutic potential of BH4 in experimental PH. METHODS: Monocrotaline-induced PH in rats and Hph-1 deficiency in mice were used for animal experiments...
November 19, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29118720/altered-right-ventricular-mechanical-properties-are-afterload-dependent-in-a-rodent-model-of-bronchopulmonary-dysplasia
#10
Jitandrakumar R Patel, Gregory P Barton, Rudolf K Braun, Kara N Goss, Kristin Haraldsdottir, Alexandria Hopp, Gary Diffee, Timothy A Hacker, Richard L Moss, Marlowe W Eldridge
Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular development in BPD affects RV contractile properties is unknown. We used a rat model of BPD to examine the effect of hyperoxia-induced PH on RV contractile properties. We measured in vivo RV pressure as well as passive force, maximum Ca(2+) activated force, calcium sensitivity of force (pCa50) and rate of force redevelopment (ktr) in RV skinned trabeculae isolated from hearts of 21-and 35-day old rats pre-exposed to 21% oxygen (normoxia) or 85% oxygen (hyperoxia) for 14 days after birth...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29109948/hemodynamic-and-pathologic-characterization-of-the-task-1-mouse-does-not-demonstrate-pulmonary-hypertension
#11
Melanie G Kitagawa, Julia O Reynolds, Xander H T Wehrens, Robert M Bryan, Lavannya M Pandit
Introduction: Pulmonary hypertension (PH) carries significant associated morbidity and mortality and the underlying molecular mechanisms of PH are not well understood. Loss-of-function mutations in TASK-1 potassium channels are associated with PH in humans. Although TASK-1 has been considered in the development of PH for over a decade, characterization of TASK-1 knockout mice has been limited to in vitro studies or in vivo studies in room air at isolated time points. The purpose of this study was twofold...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29098651/excess-body-weight-insulin-resistance-and-isolated-systolic-hypertension-potential-pathophysiological-links
#12
Lanfranco D'Elia, Pasquale Strazzullo
Isolated systolic hypertension, the most common form of hypertension in the elderly, but also detectable among young and middle-aged subjects, is independently associated with higher risk of cardiovascular events and all-cause mortality. Among various pathophysiological changes associated with aging, excess body weight and insulin resistance may predispose to this type of hypertension. Overweight or frank obesity and their frequent companion insulin resistance could mediate the development of isolated systolic hypertension through increase in the renin-angiotensin-aldosterone system activity, in the sympathetic tone and in salt-sensitivity, all in turn leading to endothelial dysfunction, arterial stiffness and increase in blood pressure...
November 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29065792/comparison-of-ambulatory-blood-pressure-monitoring-and-office-blood-pressure-measurements-in-obese-children-and-adolescents
#13
Rahime Renda
BACKGROUND: Obesity in adults has been related to hypertension and abnormal nocturnal dipping of blood pressure, which are associated with poor cardiovascular and renal outcomes. Here, we aimed to resolve the relationship between the degree of obesity, the severity of hypertension and dipping status on ambulatory blood pressure in obese children. METHODS: A total 72 patients with primary obesity aged 7 to 18 years (mean: 13.48 ± 3.25) were selected. Patients were divided into three groups based on body mass index (BMİ) Z-score...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29050845/high-rate-of-isolated-right-ventricular-dysfunction-in-patients-with-non-significant-computed-tomographic-pulmonary-angiography
#14
Frances M Russell, Jeffrey A Kline, Timothy Lahm
BACKGROUND: Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are commonly unrecognized in the emergency department (ED), but are associated with poor outcomes. Prior research has found a 30% prevalence of isolated RV dysfunction in ED patients after non-significant computed tomographic pulmonary angiography (CTPA). We aimed to prospectively define the prevalence of RV dysfunction and/or PH in short of breath ED patients, and assess outcomes. METHODS: Prospective observational study of patients with a non-significant CTPA...
October 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29041894/-clinical-features-of-arterial-hypertension-in-the-elderly-and-senile-age-and-the-rationale-for-using-the-combination-of-amlodipine-indapamide-retard
#15
D Z Kobalava, K E Shavarova
The proportion of elderly in the population is growing. The two-thirds of those over the age of 65 has arterial hypertension (AH). There is a significant increase in the incidence of isolated systolic hypertension with age. The relationship between increased pulse pressure, arterial stiffness and aging processes has been repeatedly confirmed in population epidemiological studies. Some evidence has been found that the treatment of AH in the elderly is accompanied by a reduction in the risk of cardiovascular diseases...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041880/-efficacy-of-antihypertensive-therapy-combined-with-psychotropic-drugs-in-patients-with-hypertension-and-affective-disorders
#16
V V Skibitskiy, V D Kovalev, N A Kurzanov, I A Ponomareva
AIM: To compare effects of isolated antihypertensive therapy (AHT) and AHT combined with anxiolytic and antidepressant on parameters of 24‑hour blood pressure (BP) profile, severity of affective disorders, and quality of life (QL) in patients with uncontrolled arterial hypertension (AH) and anxiety or depressive disorders. MATERIAL AND METHODS: We randomized 140 patients (age 48.6±5.9 year, 72 women) into 2 groups. During 1 year patients of each group received 2 variants of pharmacotherapy: isolated AHT and AHT combined with psychotropic medication (PM) - anxiolytic for persons with anxiety disorder and antidepressant for persons with depressive disorder (AHT+PM)...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29036350/prevalence-of-hypertension-defined-by-central-blood-pressure-measured-using-a-type-ii-device-in-a-nationally-representative-cohort
#17
Shao-Yuan Chuang, Hsing-Yi Chang, Hao-Min Cheng, Wen-Harn Pan, Chen-Huan Chen
Objectives: Central blood pressure (BP) can be used to define hypertension. A central BP approach may be more sensitive than a conventional brachial BP approach in detecting hypertension. We aimed to compare the two approaches in estimating the prevalence hypertension in a nationally representative population. Methods: A total of 2742 adults older than 19 years participated in the 2013-2016 National Nutrition and Health Survey in Taiwan. Central and brachial BP were simultaneously measured using a cuff-based stand-alone central BP monitor purporting to measure invasive central BP (Type II device)...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29016715/matrix-metalloproteinase-2-knockout-prevents-angiotensin-ii-induced-vascular-injury
#18
Tlili Barhoumi, Julio C Fraulob-Aquino, Muhammad Oneeb Rehman Mian, Sofiane Ouerd, Noureddine Idris-Khodja, Ku-Geng Huo, Asia Rehman, Antoine Caillon, Bianca Dancose-Giambattisto, Talin Ebrahimian, Stéphanie Lehoux, Pierre Paradis, Ernesto L Schiffrin
Aims: Matrix metalloproteinases (MMPs) have been implicated in the development of hypertension in animal models and humans. Mmp2 deletion did not change Ang II-induced blood pressure (BP) rise. However, whether Mmp2 knockout affects angiotensin (Ang) II-induced vascular injury has not been tested. We sought to determine whether Mmp2 knockout will prevent Ang II-induced vascular injury. Methods and results: A fourteen-day Ang II infusion (1000 ng/kg/min, SC) increased systolic BP, decreased vasodilatory responses to acetylcholine, induced mesenteric artery (MA) hypertrophic remodelling, and enhanced MA stiffness in wild-type (WT) mice...
July 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28981519/pulmonary-hypertension-subtypes-associated-with-hereditary-haemorrhagic-telangiectasia-haemodynamic-profiles-and-survival-probability
#19
Sabine Revuz, Evelyne Decullier, Isabelle Ginon, Nicolas Lamblin, Pierre-Yves Hatron, Pierre Kaminsky, Marie-France Carette, Pascal Lacombe, Anne-Claire Simon, Sophie Rivière, Jean-Robert Harlé, Alain Fraisse, Christian Lavigne, Vanessa Leguy-Seguin, Ari Chaouat, Chahera Khouatra, Sophie Dupuis-Girod, Eric Hachulla
BACKGROUND: Different pulmonary hypertension (PH) mechanisms are associated with hereditary haemorrhagic telangiectasia (HHT). METHODS AND RESULTS: We conducted a retrospective study of all suspected cases of PH (echocardiographically estimated systolic pulmonary artery pressure [sPAP] ≥ 40 mmHg) in patients with definite HHT recorded in the French National Reference Centre for HHT database. When right heart catheterization (RHC) was performed, PH cases were confirmed and classified among the PH groups according to the European guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28976377/-hypertension-in-the-elderly
#20
Filiz Özerkan Çakan
Hypertension (HT) is a common problem in elderly persons (age >65 years), reaching a prevalence as high as 60 to 80%. Isolated systolic HT mostly occurs in older patients. Treatment of HT in all patients, independent of age, consists of lifestyle modifications and antihypertensive therapy. Randomized trials have provided clear evidence of benefit from treating HT in elderly patients, including those over the age of 80 years. Drug therapy should be started in elderly hypertensive patients if lifestyle changes are insufficient and in the absence of a hypertensive emergency or urgency, blood pressure reduction should always be gradual...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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