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isolated systolic hypertension

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https://www.readbyqxmd.com/read/27866193/mixed-aqueous-extract-of-salvia-miltiorrhiza-reduces-blood-pressure-through-inhibition-of-vascular-remodelling-and-oxidative-stress-in-spontaneously-hypertensive-rats
#1
Jing Zhang, Sheng Jun An, Jun Qiu Fu, Pei Liu, Tie Mei Shao, Manli Li, Xue Li, Zhan Jiao, Xi Qing Chai
BACKGROUND/AIMS: Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), salvianolic acid B (Sal-B) and protocatechuic aldehyde (PAL), totally abbreviated as SABP. Although SM is often used to treat various cardiovascular diseases in traditional Chinese medicine, the efficacy and function of optimal compatibility ratio of SM's active ingredients (SABP) in the prevention and treatment of cardiovascular diseases remain uncertain...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27862163/the-effects-of-high-sodium-intake-on-systemic-blood-pressure-and-vascular-responses-in-spontaneously-diabetic-wbn-kob-lepr-fa-fa-rats
#2
Yoshiichi Takagi, Haruno Kadowaki, Ikumi Kobayashi, Kaoru Ito, Katsuaki Ito, Mitsuyuki Shirai, Fumitoshi Asai
The prevalence of type 2 diabetes mellitus (T2DM) and hypertension has markedly increased worldwide. The purpose of the present study was to examine the effects of a high-salt intake on the systolic blood pressure (SBP) and vascular responses in WBN/Kob-Lepr(fa/fa) (WBKDF) rats, a new spontaneous animal model of T2DM. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (0.26%, NS) diet or high-sodium (8%, HS) diet for 14 weeks: 1) Wistar rats on NS diet (Wistar-NS); 2) Wistar rats on HS diet (Wistar-HS); 3) WBKDF rats on NS diet (WBKDF-NS); 4) WBKDF rats on HS diets (WBKDF-HS)...
November 15, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27847439/lactobacillus-casei-strain-c1-attenuates-vascular-changes-in-spontaneously-hypertensive-rats
#3
Wei Boon Yap, Faisal Malau Ahmad, Yi Cheng Lim, Satirah Zainalabidin
Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8)...
November 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27803479/analysis-of-vascular-cell-response-to-hypertension-induced-by-pressure-loading-and-its-application-as-a-tool-for-exploring-pharmacological-modes-of-action
#4
Takuji Machida
 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1β (IL-1β) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. The expression of iNOS and COX-2 in cultured VSMCs isolated from 6-7-week-old stroke-prone spontaneously hypertensive rats (SHRSP) is significantly lower than in cells of normotensive Wistar Kyoto rats (WKY). These reductions are also found in cells exposed to pulsatile atmospheric pressure between 80-160 mmHg at a rate of 4 cycles/min, which simulates systolic hypertension...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27771852/threshold-and-target-for-blood-pressure-lowering-in-the-elderly
#5
Guido Grassi, Fosca Quarti-Trevano, Anna Casati, Raffaella Dell'Oro
PURPOSE OF REVIEW: Detection of elevated blood pressure values in elderly patients represents a common clinical condition associated with an increased cardiovascular risk. This has been shown to be the case in both systodiastolic and isolated systolic hypertension as well. However, despite the evidence of the benefits of the blood pressure lowering intervention in terms of reduction of cardiovascular morbidity and mortality, at least two issues related to antihypertensive drug treatment in aged individuals are still undefined: (1) the blood pressure threshold at which antihypertensive drug should be initiated and (2) the blood pressure goals of the therapeutic intervention...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27771847/multicenter-randomized-double-blind-comparison-of-nebivolol-plus-hctz-and-irbesartan-plus-hctz-in-the-treatment-of-isolated-systolic-hypertension-in-elderly-patients-results-of-the-nehis-study
#6
Guido Grassi, Gino Seravalle, Gianmaria Brambilla, Raffaella Dell'Oro, Fosca Quarti Trevano, Francesco Fici, Luc van Bortel, Giuseppe Mancia
INTRODUCTION: The present study was aimed at comparing the antihypertensive efficacy, tolerability, and side effects profile of nebivolol/hydrochlorothiazide (NH) vs irbesartan/hydrochlorothiazide (IH) combination in elderly patients with isolated systolic hypertension (ISH). METHODS: 124 ISH patients aged 69.1 ± 5.1 years (mean ± SD) were enrolled by 13 general practitioners in Netherlands and Belgium and randomized in a double-blind fashion to receive either NH (5/12...
October 22, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27754200/ish-pre-1-reduction-of-cardiovascular-mortality-in-hypertensives-with-comorbidities-beyond-blood-pressure-lowering-the-role-of-arterial-aging
#7
Michel E Safar
Mid-life elevated BP is classically associated with a raised systemic vascular resistance. A classical interpretation of the association between aortic stiffness and blood pressure (BP) invokes hypertension as a simple form of premature aging that increases stress on the arterial wall and accelerates age-related stiffening of the aorta. Recent clinical and experimental data have called into question the directionality of this sequence of events associating stiffness and hypertension.Therefore an initial abnormality in stiffness may antedate and contribute initially to the pathogenesis of hypertension, namely isolated systolic hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754161/pl-03-2-remote-blood-pressure-monitoring-in-hypertension-care-practice-of-hypertension-by-teletransmission-of-home-blood-pressure
#8
Yutaka Imai
It has been confirmed that clinical significance of home blood pressure measurements (HBPM) is higher than clinic BP measurements and ambulatory BP monitoring. However, several drawbacks of HBPM have also been mentioned, e.g. selection and reporting biases, difficulties of calculation of multiple measurements, difficulties of onsite judgement of numerous recordings, etc. Recent devices for HBPM incorporate memory function. This function can overcome such drawbacks of HBPM. These memorized data can transmit, storage, retrieve, be arithmetic and control, be judged based on algorithm and be got feedback...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#9
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754039/os-13-05-prevalence-of-central-hypertension-and-its-association-with-target-organ-damage-in-untreated-chinese-patients
#10
Yi-Bang Cheng, Ting-Yan Xu, Yan Yang, Qian-Hui Guo, Chang-Sheng Sheng, Qi-Fang Huang, Jing-Jing Li, Dong-Yan Zhang, Ji-Guang Wang, Yan Li
OBJECTIVE: Central blood pressure (BP) is suggested to be more closely correlated to target organ damage and cardiovascular events than brachial BP. Outcome-based thresholds for the diagnosis of central hypertension has been recently proposed. However, little is known about central hypertension. In an untreated patient cohort, we therefore investigated the prevalence of central hypertension and its association with target organ damage. DESIGN AND METHOD: Consecutive untreated patients referred for ambulatory BP monitoring to our Hypertension Clinic were recruited...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#11
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753981/pl-02-3-management-of-elderly-hypertension-whom-to-treat-and-how-low-to-go
#12
Michael Weber
: Age is the most powerful cardiovascular risk factor. Based on a meta-analysis of a million control patients in hypertension trials, the Clinical Trialists Collaboration has estimated that doubling of major cardiac and stroke events occurs with age increments of < 10 years (1). Data from the ACCOMPLISH trial, which will be presented at this ISH meeting for the first time, show that patients aged > 70 (mean: 75.2), compared with those < 70 (mean: 63.7), had a 2.82-fold greater event rate for cardiovascular death and a 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753957/os-09-01-prevalence-of-hypertension-after-three-separate-occasions-among-chinese-children-a-national-representative-cross-section-survey
#13
Hui Fan, Yingkun Yan, HongBo Dong, Jie Mi
OBJECTIVE: It was recommended that the diagnosis of hypertension among children should be established on at least three separate occasions. However, the national prevalence of hypertension after three separate occasions was scant in China. The goal of our study was to determine the prevalence of hypertension on up to three separate visits in a Chinese pediatric population, and examined the association between hypertension and weight status. DESIGN AND METHOD: Data were obtained from a national representative sample of 43304 children aged 6-17 years...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753798/ssa-01-1-hypertension-subtypes-in-rapidly-aging-east-asia
#14
Hyeon Chang Kim
Cardiovascular disease is the leading cause of death worldwide. Fortunately, cardiovascular mortality has been decreasing in high-income countries, but the rate is still increasing in some middle-income and low-income countries. Even within the Asian region, cardiovascular disease mortality is decreasing in some countries but increasing in others. However, population ageing is common to all Asian countries, and East Asia is among the most aged region in the world. Accordingly, cardiovascular disease prevention in the elderly is becoming more and more important public health issue in East Asia...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27739020/isolated-systolic-hypertension-in-young-and-middle-aged-adults
#15
Yuichiro Yano, Donald M Lloyd-Jones
Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and middle-aged adults. Isolated systolic hypertension (ISH) is one such example. Whether ISH in young and middle-aged adults represents "pseudo" or "spurious" hypertension is still being debated. ISH in young and middle-aged adults is a heterogeneous entity; some individuals appear to have increased stroke volume, whereas others have stiffened aortae, or both...
November 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27703956/burden-of-hypertension-and-abnormal-glomerular-permeability-in-hypertensive-school-children
#16
Adebukola B Ajite, Theophilus A Aladekomo, Temilade Aderounmu, Wasiu A Olowu
BACKGROUND: Childhood hypertension has been associated with target-organ damage in young adults. It is often asymptomatic in both children and adolescents; when persistent, and long-standing, it could be a significant risk factor for kidney damage and increased glomerular permeability. OBJECTIVES: Burden of hypertension and its impact on glomerular permeability were prospectively determined in randomly recruited primary school children. PATIENTS AND METHODS: Blood pressure (BP) measurement was performed by the auscultation method, and abnormal glomerular permeability was assessed by dipstick testing of urine for persistent proteinuria and/or hematuria for ≥ three months in hypertensive children...
July 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27694190/renal-denervation-a-blunt-weapon-against-isolated-systolic-hypertension
#17
Rosa Maria Bruno, Stefano Taddei
No abstract text is available yet for this article.
October 2, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27677132/isolate-systolic-hypertension-and-central-pressures-in-elderly-patients-differences-between-men-and-women-with-similar-peripheral-pressures
#18
R M Cabrera-Sole, L Urrego Rivera, C Turpin Lucas, D Calle Salazar, M Aguilera Saldaña
No abstract text is available yet for this article.
July 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27670145/zofenopril-exerts-a-cardiovascular-protective-effect-on-rats-infused-with-angiotensin-ii-beyond-angiotensin-converting-enzyme-inhibition
#19
Miriam Gómez-Roso, María J Montero, Rosalía Carrón, María A Sevilla
OBJECTIVES: Elevated levels of angiotensin II are implicated in the hypertensive pathophysiological process. Zofenopril has a sulphydryl group which gives it antioxidant properties. The aim of this study was to investigate its beneficial effects beyond angiotensin-converting enzyme (ACE) inhibition using angiotensin II-infused rats as hypertension model. METHODS: Zofenopril was added in drinking water. Systolic blood pressure was assessed by the tail-cuff method...
September 27, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27664183/microbial-short-chain-fatty-acid-metabolites-lower-blood-pressure-via-endothelial-g-protein-coupled-receptor-41
#20
Niranjana Natarajan, Daijiro Hori, Sheila Flavahan, Jochen Steppan, Nicholas A Flavahan, Dan E Berkowitz, Jennifer L Pluznick
Short chain fatty acid (SCFA) metabolites are byproducts of gut microbial metabolism that are known to affect host physiology via GPCRs. We previously showed that an acute SCFA bolus decreases blood pressure (BP) in anesthetized mice, an effect mediated via Gpr41. In this study, our aims were to identify the cellular localization of Gpr41 and to determine its role in BP regulation. We localized Gpr41 to the vascular endothelium using RT-PCR: Gpr41 is detected in intact vessels, but is absent from denuded vessels...
September 23, 2016: Physiological Genomics
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