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isolated systolic hypertension

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https://www.readbyqxmd.com/read/28424510/the-effect-of-slow-loaded-breathing-training-on-the-blood-pressure-response-to-handgrip-exercise-in-patients-with-isolated-systolic-hypertension
#1
Chulee Ubolsakka-Jones, Benjarat Sangthong, Wilaiwan Khrisanapant, David A Jones
Isolated systolic hypertension (ISH) is the most common form of hypertension in older people. It is characterized by increased resting systolic blood pressure (sBP) and increased sBP in response to exercise. It has previously been shown that slow breathing training reduces resting sBP, and the objective of the present study was to determine whether it also reduced the blood pressure response to static handgrip exercise. ISH patients aged between 60 and 74 years were randomly divided into a control group (10 subjects, 4 of which were male) that breathed normally and a trained group (10 subjects, 4 of which were male) that trained daily for 8 weeks by slow breathing against an inspiratory resistance of 18 cmH2O...
April 20, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28414077/hypotensive-acute-effect-of-photobiomodulation-therapy-on-hypertensive-rats
#2
J C Oishi, T F De Moraes, T C Buzinari, E C Cárnio, N A Parizotto, G J Rodrigues
The purpose of this study was to evaluate the acute effect of photobiomodulation therapy (PBM) on arterial pressure in hypertensive and normotensive rats with application in an abdominal region. Normotensive (2K) and hypertensive (2K-1C) wistar rats were treated with PBM. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP) and heart rate (HR) were measured before, during and after PBM application. The nitric oxide (NO) serum concentration was measured before and after PBM application...
April 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28405802/vasculo-protective-effect-of-bms-309403-is-independent-of-its-specific-inhibition-of-fatty-acid-binding-protein-4
#3
Yuta Okamura, Kosuke Otani, Akihiro Sekiguchi, Taisuke Kogane, Chiharu Kakuda, Yuzaburo Sakamoto, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki
Fatty acid-binding protein (FABP) 4 is an adipocytokine mainly expressed in adipocyte and macrophage. Blood FABP4 is related not only to metabolic disorders including insulin resistance and atherosclerosis but also increased blood pressure. We tested the hypothesis that FABP4 plays roles in pathogenesis of hypertension development including proliferation, migration, and inflammation of vascular smooth muscle cells (SMCs) as well as contractile reactivity. FABP4 alone had no influence on proliferation, migration, and inflammation of rat mesenteric arterial SMCs, while it significantly enhanced smooth muscle contraction and increases of systolic blood pressure (SBP) induced by noradrenaline (NA)...
April 13, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-pre-eclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#4
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction...
April 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28374153/isolated-systolic-hypertension-in-young-individuals-pathophysiological-mechanisms-prognostic-significance-and-clinical-implications
#5
Francesca Saladini, Paolo Palatini
Isolated systolic hypertension (ISH) is the most common form of hypertension in older persons and its predictive value for adverse outcome is well known. However, ISH can be frequently found also in young individuals, especially among males, but its prognostic significance in this setting is still controversial. Increased large artery stiffness is the main determinant of ISH in elderly patients whereas the mechanisms that lead to ISH in the young are still debated. According to some authors ISH in youth is a totally benign condition that can be called "spurious hypertension" a phenomenon due to enhanced pulse pressure amplification of the pulse wave from central to peripheral sites...
April 3, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28349252/prevalence-of-childhood-hypertension-and-hypertension-phenotypes-by-weight-status-and-waist-circumference-the-healthy-growth-study
#6
Yannis Manios, K Karatzi, A D Protogerou, G Moschonis, C Tsirimiagou, O Androutsos, C Lionis, G P Chrousos
PURPOSE: The aim of the present study was to report for the first time the prevalence of hypertension and its phenotypes in obese children and in children with central obesity in a large sample of Greek children. METHODS: A regionally representative sample of 2263 schoolchildren (50.3% boys) (9-13 years) having full data on blood pressure assessment, physical examination, anthropometric, and physical activity participated in a cross-sectional study in Greece. RESULTS: Prevalence of stage 1 and 2 hypertension, of isolated systolic hypertension (ISH) and of combined systolic or diastolic hypertension, was significantly higher for obese children and children on the 3rd tertile of waist circumference in the total sample, as well as in each gender separately...
March 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28343761/isolated-diastolic-hypertension-and-incident-heart-failure-in-community-dwelling-older-adults-insights-from-the-cardiovascular-health-study
#7
Helen M Sheriff, Apostolos Tsimploulis, Miroslava Valentova, Markus S Anker, Prakash Deedwania, Maciej Banach, Charity J Morgan, Marc R Blackman, Gregg C Fonarow, Michel White, Kannayiram Alagiakrishnan, Richard M Allman, Wilbert S Aronow, Stefan D Anker, Ali Ahmed
BACKGROUND: Isolated systolic hypertension and isolated diastolic hypotension are common in older adults and associated with a higher risk of incident heart failure (HF). However, little is known about the prevalence and impact of isolated diastolic hypertension in this population. METHODS: In the Cardiovascular Health Study (CHS), of the 5776 community-dwelling older adults ≥65years who had data on baseline systolic and diastolic blood pressure (SBP and DBP), 28 had isolated diastolic hypertension (DBP ≥90mmHg and SBP <140mmHg)...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28329267/right-ventricular-recovery-after-bilateral-lung-transplantation-for-pulmonary-arterial-hypertension%C3%A2
#8
Thomas M Gorter, Erik A M Verschuuren, Dirk J van Veldhuisen, Elke S Hoendermis, Michiel E Erasmus, Harm J Bogaard, Anton Vonk Noordegraaf, Rolf M F Berger, Joost P van Melle, Tineke P Willems
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a progressive and often fatal disease characterized by increased pulmonary vascular resistance (PVR) and right ventricular (RV) failure. End-stage PAH is often an indication for a lung transplant (LTX). Our goal was to study ventricular recovery using cardiac magnetic resonance imaging late after LTX. METHODS: We studied 10 patients with PAH who underwent isolated bilateral LTX. RV and left ventricular (LV) volumes, function and mass were measured...
March 3, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28320856/sustained-reduction-of-blood-pressure-with-baroreceptor-activation-therapy-results-of-the-6-year-open-follow-up
#9
Peter W de Leeuw, John D Bisognano, George L Bakris, Mitra K Nadim, Hermann Haller, Abraham A Kroon
Baroreflex activation therapy is a novel technique for treating patients with resistant hypertension. Although short-term studies have demonstrated that it lowers blood pressure, long-term results have not yet been reported. The aim of the present study is to assess the long-term efficacy and safety of baroreflex activation therapy. Long-term follow-up data were analyzed from all patients who had been included in 1 of the 3 trials that focused on treatment-resistant hypertensive patients. Altogether, 383 patients were available for analysis: 143 of these had completed 5 years of follow-up and 48 patients had completed 6 years of follow-up...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28291625/systolic-diastolic-hypertension-versus-isolated-systolic-hypertension-and-incident-heart-failure-in-older-adults-insights-from-the-cardiovascular-health-study
#10
Apostolos Tsimploulis, Helen M Sheriff, Phillip H Lam, Daniel J Dooley, Markus S Anker, Vasilios Papademetriou, Ross D Fletcher, Charles Faselis, Gregg C Fonarow, Prakash Deedwania, Michel White, Miroslava Valentova, Marc R Blackman, Maciej Banach, Charity J Morgan, Kannayiram Alagiakrishnan, Richard M Allman, Wilbert S Aronow, Stefan D Anker, Ali Ahmed
BACKGROUND: Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic-diastolic hypertension (SDH) with incident HF and other outcomes in older adults. METHODS: In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults≥65years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP<60mmHg (n=821), DBP≥90 and SBP<140mmHg (n=28), normal BP, taking anti-hypertensive drugs (n=1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n=193), and baseline HF (n=101)...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28290818/-antihypertensive-therapy-and-its-efficacy-in-outpatient-elderly-and-very-elderly-subjects
#11
O N Tkacheva, V S Ostapenko, N K Runikhina, Yu V Kotovskaya
PURPOSE OF THE STUDY: The study of the characteristics and effectiveness of antihypertensive therapy (AHT) in patients aged 65 years and older. MATERIAL AND METHODS: The study included 356 patients, mean age 74,9+/-6,1 years, 80.4% women. The prevalence of arterial hypertension (AH) and the current intake of antihypertensive drugs were evaluated by self-reported patient. RESULTS: The prevalence of hypertension was 88.5%. The predominant variant was isolated systolic hypertension...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28287293/-classical-antihypertensive-drugs-diuretics
#12
Viktor László Nagy
The diuretics are essential medicaments of antihypertensive therapy. They reduce blood pressure and cardiovascular events optimally. With increasing doses of thiazides and thiazide analogs do not come further powerful effect of reducing blood pressure or cardiovascular mortality and morbidity, but clearly elevate the side effects. Because of it, the minimum effective dose level and the fixed-dose combination therapy should be preferred. The use these drugs leads to especially positive outcome in elder patients, isolated systolic hypertension, heart failure, after stroke and in black population...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28275070/left-ventricular-hypertrophy-regression-during-antihypertensive-treatment-in-an-outpatient-clinic-the-campania-salute-network
#13
Mai Tone Lønnebakken, Raffaele Izzo, Costantino Mancusi, Eva Gerdts, Maria Angela Losi, Grazia Canciello, Giuseppe Giugliano, Nicola De Luca, Bruno Trimarco, Giovanni de Simone
BACKGROUND: Regression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH. METHODS AND RESULTS: Patients from the Campania Salute Network, free of prevalent cardiovascular disease, but with echocardiographic LVH (defined as LV mass index [LVMi] >47 g/m(2...
March 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28275067/impact-of-achieved-blood-pressure-on-first-stroke-in-uncomplicated-grade-1-hypertension
#14
Xianhui Qin, Youbao Li, Ningling Sun, Mingli He, Genfu Tang, Delu Yin, JiGuang Wang, Min Liang, Binyan Wang, Yong Huo, Xin Xu, Xiping Xu, Fan Fan Hou
BACKGROUND: We aimed to test the impact of achieved blood pressure (BP) on first stroke among patients with grade 1 hypertension and without cardiovascular diseases in the China Stroke Primary Prevention Trial. METHODS AND RESULTS: A total of 3187 patients with uncomplicated grade 1 hypertension were included. The risk of outcomes was assessed according to: (1) the proportion of visits in which BP was reduced to <140/90 mm Hg, and (2) the time-averaged systolic BP (SBP) or diastolic BP levels during the study treatment period...
March 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28272200/successful-percutaneous-stent-implantation-for-isolated-dismal-transverse-aortic-arch-kinking
#15
Zhi-Liang Zuo, Jia-Yu Tsauo, Mao Chen, Yuan Feng
RATIONALE: Isolated dismal transverse aortic arch kinking in adults is rare, and there is no recommended therapy at present. Percutaneous stent implantation may be an effective method to correct it and could be considered. PATIENT CONCERNS: We report a 46-year-old woman who suffered from recurrent migraine and refractory hypertension with a significant systolic blood pressure difference between upper limbs. DIAGNOSES: The woman was diagnosed with isolated dismal transverse aortic arch kinking with refractory hypertension...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28260186/efficacy-of-zofenopril-vs-irbesartan-in-combination-with-a-thiazide-diuretic-in-hypertensive-patients-with-multiple-risk-factors-not-controlled-by-a-previous-monotherapy-a-review-of-the-double-blind-randomized-z-studies
#16
REVIEW
Stefano Omboni, Ettore Malacco, Claudio Napoli, Pietro Amedeo Modesti, Athanasios Manolis, Gianfranco Parati, Enrico Agabiti-Rosei, Claudio Borghi
Combinations between an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB) and hydrochlorothiazide (HCTZ) are among the recommended treatments for hypertensive patients uncontrolled by monotherapy. Four randomized, double-blind, parallel group studies with a similar design, including 1469 hypertensive patients uncontrolled by a previous monotherapy and with ≥1 cardiovascular risk factor, compared the efficacy of a combination of a sulfhydryl ACE inhibitor (zofenopril at 30 or 60 mg) or an ARB (irbesartan at 150 or 300 mg) plus HCTZ 12...
March 4, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28238241/mitral-patient-prosthesis-mismatch-predicts-suboptimal-hemodynamic-recovery-after-mitral-valve-replacement
#17
Sertan Ozyalcin, Kerem M Vural, Ayse Colak
BACKGROUND: A possible relationship between an obstructive prosthesis and suboptimal hemodynamic recovery, as reflected by unsatisfactory regression in systolic pulmonary artery pressure (sPAP) and functional tricuspid regurgitation (FTR) following mitral valve replacement (MVR), was investigated. A delineating effective orifice area index (EOAI) value was sought in order to define a patient-prosthesis mismatch. METHODS: A total of 128 patients undergoing isolated mechanical MVR were followed up for a mean of 46 ± 9 months...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28199358/association-between-carotid-atherosclerosis-and-different-subtypes-of-hypertension-in-adult-populations-a-multiethnic-study-in-xinjiang-china
#18
Yun Wu, Fen Liu, Dilare Adi, Yi-Ning Yang, Xiang Xie, Xiao-Mei Li, Xiang Ma, Zhen-Yan Fu, Ying Huang, Bang-Dang Chen, Chun-Fang Shan, Yi-Tong Ma
BACKGROUND: Ethnic differences in non-invasive measurements of carotid atherosclerosis are being increasingly reported, but the association between carotid atherosclerosis and different subtypes of hypertension in adult populations is not fully understood in different ethnicities. We aimed to investigate the association of carotid atherosclerosis with different subtypes of hypertension in different ethnicities in Xinjiang, a northwestern province in China. METHODS: A total of 14,618 participants (5,757 Hans, 4,767 Uygurs, and 4,094 Kazakhs) from 26 villages of seven cities in Xinjiang were randomly selected from the Cardiovascular Risk Survey conducted during 2007 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28187784/let-7a-transfected-mesenchymal-stem-cells-ameliorate-monocrotaline-induced-pulmonary-hypertension-by-suppressing-pulmonary-artery-smooth-muscle-cell-growth-through-stat3-bmpr2-signaling
#19
Gesheng Cheng, Xingye Wang, Yongxin Li, Lu He
BACKGROUND: Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplasia. Mesenchymal stem cells (MSCs) have been recently acknowledged as a potential cell vector for gene therapy. Here, we investigated the effect of MSC-based let-7a for PAH. METHODS: After isolation and identification of MSCs from rat bone marrow, cells were infected with recombinant adenovirus vector Ad-let-7a...
February 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28178938/messenger-rna-and-microrna-transcriptomic-signatures-of-cardiometabolic-risk-factors
#20
David D McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J Munson, Martin G Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E Freedman, Daniel Levy
BACKGROUND: Cardiometabolic (CM) risk factors are heritable and cluster in individuals. We hypothesized that CM risk factors are associated with multiple shared and unique mRNA and microRNA (miRNA) signatures. We examined associations of mRNA and miRNA levels with 6 CM traits: body mass index, HDL-cholesterol and triglycerides, fasting glucose, and systolic and diastolic blood pressures through cross-sectional analysis of 2812 Framingham Heart Study who had whole blood collection for RNA isolation for mRNA and miRNA expression studies and who consented to genetic research...
February 8, 2017: BMC Genomics
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