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isolated systolic hypertension

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https://www.readbyqxmd.com/read/29151830/antihypertensive-properties-of-tilapia-oreochromis-spp-frame-and-skin-enzymatic-protein-hydrolysates
#1
Hsin-Chieh Lin, Adeola M Alashi, Rotimi E Aluko, Bonnie Sun Pan, Yu-Wei Chang
Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein isolates (FPI and SPI). The most active hydrolysate was then tested for blood pressure-lowering ability in spontaneously hypertensive rats (SHRs). Tilapia frame and skin protein hydrolysates (FPHs and SPHs) were respectively produced from FPI and SPI hydrolysis using pepsin, papain, or bromelain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29151278/tetrahydrobiopterin-bh4-targeting-endothelial-nitric-oxide-synthase-as-a-potential-therapy-for-pulmonary-hypertension
#2
Bahaa N Francis, Maram Salameh, Rola Khamisy-Farah, Raymond Farah
PURPOSE: Pulmonary Hypertension (PH) is complex disease which is associated with endothelial and cardiac dysfunction. Tetrahydrobiopterin (BH4 ) regulates endothelial nitric oxide synthase (eNOS) to produce nitric oxide rather than superoxide which maintains normal endothelial and cardiac function. This study explores the therapeutic potential of BH4 in experimental PH. METHODS: Monocrotaline-induced PH in rats and Hph-1 deficiency in mice were used for animal experiments...
November 19, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29118720/altered-right-ventricular-mechanical-properties-are-afterload-dependent-in-a-rodent-model-of-bronchopulmonary-dysplasia
#3
Jitandrakumar R Patel, Gregory P Barton, Rudolf K Braun, Kara N Goss, Kristin Haraldsdottir, Alexandria Hopp, Gary Diffee, Timothy A Hacker, Richard L Moss, Marlowe W Eldridge
Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular development in BPD affects RV contractile properties is unknown. We used a rat model of BPD to examine the effect of hyperoxia-induced PH on RV contractile properties. We measured in vivo RV pressure as well as passive force, maximum Ca(2+) activated force, calcium sensitivity of force (pCa50) and rate of force redevelopment (ktr) in RV skinned trabeculae isolated from hearts of 21-and 35-day old rats pre-exposed to 21% oxygen (normoxia) or 85% oxygen (hyperoxia) for 14 days after birth...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29109948/hemodynamic-and-pathologic-characterization-of-the-task-1-mouse-does-not-demonstrate-pulmonary-hypertension
#4
Melanie G Kitagawa, Julia O Reynolds, Xander H T Wehrens, Robert M Bryan, Lavannya M Pandit
Introduction: Pulmonary hypertension (PH) carries significant associated morbidity and mortality and the underlying molecular mechanisms of PH are not well understood. Loss-of-function mutations in TASK-1 potassium channels are associated with PH in humans. Although TASK-1 has been considered in the development of PH for over a decade, characterization of TASK-1 knockout mice has been limited to in vitro studies or in vivo studies in room air at isolated time points. The purpose of this study was twofold...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29098651/excess-body-weight-insulin-resistance-and-isolated-systolic-hypertension-potential-pathophysiological-links
#5
Lanfranco D'Elia, Pasquale Strazzullo
Isolated systolic hypertension, the most common form of hypertension in the elderly, but also detectable among young and middle-aged subjects, is independently associated with higher risk of cardiovascular events and all-cause mortality. Among various pathophysiological changes associated with aging, excess body weight and insulin resistance may predispose to this type of hypertension. Overweight or frank obesity and their frequent companion insulin resistance could mediate the development of isolated systolic hypertension through increase in the renin-angiotensin-aldosterone system activity, in the sympathetic tone and in salt-sensitivity, all in turn leading to endothelial dysfunction, arterial stiffness and increase in blood pressure...
November 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29065792/comparison-of-ambulatory-blood-pressure-monitoring-and-office-blood-pressure-measurements-in-obese-children-and-adolescents
#6
Rahime Renda
BACKGROUND: Obesity in adults has been related to hypertension and abnormal nocturnal dipping of blood pressure, which are associated with poor cardiovascular and renal outcomes. Here, we aimed to resolve the relationship between the degree of obesity, the severity of hypertension and dipping status on ambulatory blood pressure in obese children. METHODS: A total 72 patients with primary obesity aged 7 to 18 years (mean: 13.48 ± 3.25) were selected. Patients were divided into three groups based on body mass index (BMİ) Z-score...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29050845/high-rate-of-isolated-right-ventricular-dysfunction-in-patients-with-non-significant-computed-tomographic-pulmonary-angiography
#7
Frances M Russell, Jeffrey A Kline, Timothy Lahm
BACKGROUND: Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are commonly unrecognized in the emergency department (ED), but are associated with poor outcomes. Prior research has found a 30% prevalence of isolated RV dysfunction in ED patients after non-significant computed tomographic pulmonary angiography (CTPA). We aimed to prospectively define the prevalence of RV dysfunction and/or PH in short of breath ED patients, and assess outcomes. METHODS: Prospective observational study of patients with a non-significant CTPA...
October 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29041894/-clinical-features-of-arterial-hypertension-in-the-elderly-and-senile-age-and-the-rationale-for-using-the-combination-of-amlodipine-indapamide-retard
#8
D Z Kobalava, K E Shavarova
The proportion of elderly in the population is growing. The two-thirds of those over the age of 65 has arterial hypertension (AH). There is a significant increase in the incidence of isolated systolic hypertension with age. The relationship between increased pulse pressure, arterial stiffness and aging processes has been repeatedly confirmed in population epidemiological studies. Some evidence has been found that the treatment of AH in the elderly is accompanied by a reduction in the risk of cardiovascular diseases...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041880/-efficacy-of-antihypertensive-therapy-combined-with-psychotropic-drugs-in-patients-with-hypertension-and-affective-disorders
#9
V V Skibitskiy, V D Kovalev, N A Kurzanov, I A Ponomareva
AIM: To compare effects of isolated antihypertensive therapy (AHT) and AHT combined with anxiolytic and antidepressant on parameters of 24‑hour blood pressure (BP) profile, severity of affective disorders, and quality of life (QL) in patients with uncontrolled arterial hypertension (AH) and anxiety or depressive disorders. MATERIAL AND METHODS: We randomized 140 patients (age 48.6±5.9 year, 72 women) into 2 groups. During 1 year patients of each group received 2 variants of pharmacotherapy: isolated AHT and AHT combined with psychotropic medication (PM) - anxiolytic for persons with anxiety disorder and antidepressant for persons with depressive disorder (AHT+PM)...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29036350/prevalence-of-hypertension-defined-by-central-blood-pressure-measured-using-a-type-ii-device-in-a-nationally-representative-cohort
#10
Shao-Yuan Chuang, Hsing-Yi Chang, Hao-Min Cheng, Wen-Harn Pan, Chen-Huan Chen
Objectives: Central blood pressure (BP) can be used to define hypertension. A central BP approach may be more sensitive than a conventional brachial BP approach in detecting hypertension. We aimed to compare the two approaches in estimating the prevalence hypertension in a nationally representative population. Methods: A total of 2742 adults older than 19 years participated in the 2013-2016 National Nutrition and Health Survey in Taiwan. Central and brachial BP were simultaneously measured using a cuff-based stand-alone central BP monitor purporting to measure invasive central BP (Type II device)...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29016715/matrix-metalloproteinase-2-knockout-prevents-angiotensin-ii-induced-vascular-injury
#11
Tlili Barhoumi, Julio C Fraulob-Aquino, Muhammad Oneeb Rehman Mian, Sofiane Ouerd, Noureddine Idris-Khodja, Ku-Geng Huo, Asia Rehman, Antoine Caillon, Bianca Dancose-Giambattisto, Talin Ebrahimian, Stéphanie Lehoux, Pierre Paradis, Ernesto L Schiffrin
Aims: Matrix metalloproteinases (MMPs) have been implicated in the development of hypertension in animal models and humans. Mmp2 deletion did not change Ang II-induced blood pressure (BP) rise. However, whether Mmp2 knockout affects angiotensin (Ang) II-induced vascular injury has not been tested. We sought to determine whether Mmp2 knockout will prevent Ang II-induced vascular injury. Methods and results: A fourteen-day Ang II infusion (1000 ng/kg/min, SC) increased systolic BP, decreased vasodilatory responses to acetylcholine, induced mesenteric artery (MA) hypertrophic remodelling, and enhanced MA stiffness in wild-type (WT) mice...
July 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28981519/pulmonary-hypertension-subtypes-associated-with-hereditary-haemorrhagic-telangiectasia-haemodynamic-profiles-and-survival-probability
#12
Sabine Revuz, Evelyne Decullier, Isabelle Ginon, Nicolas Lamblin, Pierre-Yves Hatron, Pierre Kaminsky, Marie-France Carette, Pascal Lacombe, Anne-Claire Simon, Sophie Rivière, Jean-Robert Harlé, Alain Fraisse, Christian Lavigne, Vanessa Leguy-Seguin, Ari Chaouat, Chahera Khouatra, Sophie Dupuis-Girod, Eric Hachulla
BACKGROUND: Different pulmonary hypertension (PH) mechanisms are associated with hereditary haemorrhagic telangiectasia (HHT). METHODS AND RESULTS: We conducted a retrospective study of all suspected cases of PH (echocardiographically estimated systolic pulmonary artery pressure [sPAP] ≥ 40 mmHg) in patients with definite HHT recorded in the French National Reference Centre for HHT database. When right heart catheterization (RHC) was performed, PH cases were confirmed and classified among the PH groups according to the European guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28976377/-hypertension-in-the-elderly
#13
Filiz Özerkan Çakan
Hypertension (HT) is a common problem in elderly persons (age >65 years), reaching a prevalence as high as 60 to 80%. Isolated systolic HT mostly occurs in older patients. Treatment of HT in all patients, independent of age, consists of lifestyle modifications and antihypertensive therapy. Randomized trials have provided clear evidence of benefit from treating HT in elderly patients, including those over the age of 80 years. Drug therapy should be started in elderly hypertensive patients if lifestyle changes are insufficient and in the absence of a hypertensive emergency or urgency, blood pressure reduction should always be gradual...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28971696/hydrogen-sulfide-ameliorated-l-name-induced-hypertensive-heart-disease-by-the-akt-enos-no-pathway
#14
Sheng Jin, Xu Teng, Lin Xiao, Hongmei Xue, Qi Guo, Xiaocui Duan, Yuhong Chen, Yuming Wu
Reductions in hydrogen sulfide (H2S) production have been implicated in the pathogenesis of hypertension; however, no studies have examined the functional role of hydrogen sulfide in hypertensive heart disease. We hypothesized that the endogenous production of hydrogen sulfide would be reduced and exogenous hydrogen sulfide would ameliorate cardiac dysfunction in N(ω)-nitro- L-arginine methyl ester ( L-NAME)-induced hypertensive rats. Therefore, this study investigated the cardioprotective effects of hydrogen sulfide on L-NAME-induced hypertensive heart disease and explored potential mechanisms...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28970627/systemic-hypertension-and-non-cardiac-surgery
#15
REVIEW
Satyajeet Misra
Primary systemic hypertension affects 10%-25% of individuals presenting for surgery and anaesthesia and constitutes an important cause of cancellation of elective surgeries. Much of the fear stems from the fact that hypertension may lead to adverse perioperative outcomes. Although long-standing hypertension increases the risk of stroke, renal dysfunction or major adverse cardiovascular events, the same is usually not seen in the perioperative period if blood pressure is <180/110 mmHg and this has been the overriding theme in the recent guidelines on perioperative blood pressure management...
September 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28961317/assessing-emotional-processing-difficulties-in-normotensive-individuals-with-high-and-isolated-blood-pressure-elevations
#16
Meenakshi Shukla, Rakesh Pandey, Jennifer Y F Lau
This study examined the effect of sense modality (auditory/visual) on emotional dampening (reduced responsiveness to emotions with elevation in blood pressure). Fifty-six normotensive participants were assessed on tasks requiring labelling and matching of emotions in faces and voices. Based on median split of systolic and diastolic blood pressures (SBP and DBP, respectively), participants were divided into low BP, high BP and isolated BP groups. On emotion-labelling tasks, analysis revealed reduced emotion recognition in the high BP than the low BP group...
September 29, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28944174/hypertrophic-obstructive-cardiomyopathy-the-leipzig-experience
#17
Jawad Khalil, Michael Kuehl, Pirose Davierwala, Friedrich Wilhelm Mohr, Martin Misfeld
BACKGROUND: Management of hypertrophic obstructive cardiomyopathy (HOCM) has evolved considerably over the last fifty years, and includes medical treatment as well as septal myectomy (SM) to relief symptoms caused by left ventricular outflow tract obstruction (LVOTO). We report the Leipzig Heart Center experience in the surgical management of patients with HOCM. METHODS: We collected data from all patient treated surgically with a myectomy for LVOTO in patients with HOCM between 1997 and 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28830209/puerarin-improves-vascular-insulin-resistance-and-cardiovascular-remodeling-in-salt-sensitive-hypertension
#18
Chunxiang Tan, Aimei Wang, Chan Liu, Yao Li, Yuepin Shi, Ming-Sheng Zhou
Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28817494/nocturnal-hypertension-and-right-heart-remodeling
#19
Marijana Tadic, Cesare Cuspidi, Vera Celic, Biljana Pencic-Popovic, Giuseppe Mancia
BACKGROUND: We sought to investigate right ventricular (RV) and right atrial mechanics in patients with daytime, night-time and daytime-night-time hypertension. METHODS: This cross-sectional study included 256 untreated patients who underwent 24-h ambulatory blood pressure monitoring and complete echocardiographic examination including strain analysis. Night-time hypertension was defined as nocturnal SBP at least 120 mmHg and/or DBP at least 70 mmHg and daytime hypertension as SBP at least 135 mmHg and/or DBP at least 85 mmHg...
August 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28814438/collecting-duct-prorenin-receptor-knockout-reduces-renal-function-increases-na-excretion-and-mitigates-renal-responses-in-angii-induced-hypertensive-mice
#20
Minolfa C Prieto, Virginia Reverte, Mykola Mamenko, Marta Kuczeriska, Luciana C Veiras, Carla B Rosales, Matthew McLellan, Oliver Gentile, V Behrana Jensen, Atsuhiro Ichihara, Alicia A McDonough, Oleh M Pochynyuk, Alexis A Gonzalez
Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na+ reabsorption via activation of epithelial Na+ channels (ENaC) and other transporters, which leads to the development of high blood pressure (BP). In ANGII-induced hypertension, there is increased expression of the prorenin receptor (PRR) in the collecting duct (CD), which has been implicated in the stimulation of the sodium transporters and resultant hypertension. The impact of PRR deletion along the nephron on BP regulation and Na+ handling remains controversial...
August 16, 2017: American Journal of Physiology. Renal Physiology
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