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isolated systolic hypertension

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https://www.readbyqxmd.com/read/29753173/comparative-effects-of-avocado-oil-and-losartan-on-blood-pressure-renal-vascular-function-and-mitochondrial-oxidative-stress-in-hypertensive-rats
#1
Cristian Adrián Márquez-Ramírez, José Lucio Hernández de la Paz, Omar Ortiz-Avila, Andrés Raya-Farias, Juan Carlos González-Hernández, Alain Raimundo Rodríguez-Orozco, Rafael Salgado-Garciglia, Alfredo Saavedra-Molina, Daniel Godínez-Hernández, Christian Cortés-Rojo
OBJECTIVE: Angiotensin II (Ang-II) antagonism alleviates hypertensive kidney damage by improving mitochondrial function and decreasing oxidative stress. This condition also is associated with altered renal vascular tone due to enhanced constriction by Ang-II. Thus, approaches ameliorating these events are desirable to alleviate kidney damage. Avocado oil, a source of antioxidants and oleic acid, is known to improve mitochondrial function, while oleic acid has antihypertensive effects...
March 20, 2018: Nutrition
https://www.readbyqxmd.com/read/29747759/limonin-alleviates-macro-and-micro-vascular-complications-of-metabolic-syndrome-in-rats-a-comparative-study-with-azelnidipine
#2
Noura A Hassan, Hany M El Bassossy, Ahmed Fahmy, Mona F Mahmoud
BACKGROUND: Hypertension is a serious component of metabolic syndrome (MetS). HYPOTHESIS: This research investigates the potential protective effect of limonin against MetS-associated hypertension in comparison with azelnidipine, a common calcium channel blocker. STUDY DESIGN: MetS was induced in rats by 10% fructose in water and 3% salt in diet over a 16-week period. Limonin (50 mg/kg) and azelnidipine (5 mg/kg) were administered daily in the last four weeks METHODS: Non-invasive blood pressure (BP) was recorded in conscious animals...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29741931/arginase-up-regulation-and-enos-uncoupling-contribute-to-impaired-endothelium-dependent-vasodilation-in-a-rat-model-of-intrauterine-growth-restriction
#3
Isabelle Grandvuillemin, Christophe Buffat, Farid Boubred, Edouard Lamy, Julien Fromonot, Philippe Charpiot, Stephanie Simoncini, Florence Sabatier, Françoise Dignat-George, Anne-Christine Peyter, Umberto Simeoni, Catherine Yzydorczyk
Individuals born after intrauterine growth restriction (IUGR) are at increased risk of developing cardiovascular diseases in adulthood, notably hypertension (HTN). Alterations in the vascular system, particularly impaired endothelium-dependent vasodilation, may play an important role in long-term effects of IUGR. Whether such vascular dysfunction precedes HTN has not been fully established in individuals born after IUGR. Moreover, the intimate mechanisms of altered endothelium-dependent vasodilation remain incompletely elucidated...
May 9, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29733824/preoperative-aortic-arch-size-and-late-outcome-following-coarctation-repair-via-lateral-thoracotomy
#4
Preeti Ramachandran, Philip R Khoury, Robert H Beekman, Erik C Michelfelder, Peter B Manning, James S Tweddell, James F Cnota
BACKGROUND: The approach (lateral thoracotomy vs median sternotomy) to repair coarctation of aorta is frequently based on arch dimensions from the preoperative echocardiogram. Few studies have assessed the relationship between preoperative arch dimensions and late postoperative outcome. This study aims to define how preoperative arch dimensions relate to late outcomes and identify long term predictors of successful surgery. METHODS: We performed a retrospective review of 102 neonates and infants undergoing isolated coarctation repair via lateral thoracotomy between 2003-2012...
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29713047/cardiovascular-morbidity-of-severe-resistant-hypertension-among-treated-uncontrolled-hypertensives-a-4-year-follow-up-study
#5
Alexandros Kasiakogias, Costas Tsioufis, Kyriakos Dimitriadis, Dimitrios Konstantinidis, Areti Koumelli, Ioannis Leontsinis, Eirini Andrikou, Nikos Vogiatzakis, Smaragdi Marinaki, Dimitrios Petras, Christos Fragoulis, Konstantinos Konstantinou, Vasilios Papademetriou, Dimitrios Tousoulis
Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP < 160 mmHg) and 200 (12%) with severe RHTN (systolic BP ≥ 160 mmHg)...
May 1, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29705351/stimulation-of-nitric-oxide-sensitive-soluble-guanylate-cyclase-in-monocrotaline-induced-pulmonary-hypertensive-rats
#6
Masashi Tawa, Takahide Furukawa, Hiroko Tongu, Mai Sugihara, Satoko Taguwa, Misaki Yamanaka, Yoko Yano, Hiroaki Matsumori, Rie Kitada, Tatsuya Sawano, Ryosuke Tanaka, Mamoru Ohkita, Yasuo Matsumura
AIMS: In this study, we examined whether a disruption in the balance between nitric oxide (NO)-sensitive and -insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO-enhancing drugs can halt disease progression. MAIN METHODS: Rats were injected subcutaneously with saline or 60 mg/kg monocrotaline (MCT). At 14 days after injection, the vascular reactivity of isolated extralobar pulmonary arteries was assessed by organ chamber technique...
April 26, 2018: Life Sciences
https://www.readbyqxmd.com/read/29701349/pulmonary-hypertension-in-valvular-heart-disease-surgery-risk-and-prognosis
#7
Márcio Madeira, Sara Ranchordás, Paulo Oliveira, Tiago Nolasco, Marta Marques, Luis Bruges, José Calquinha, Miguel Sousa Uva, Miguel Abecasis, José Pedro Neves
INTRODUCTION: Left heart disease is the most common cause of pulmonary hypertension (PH), and when present is associated with higher surgical risk. OBJECTIVES: Analyze the effect of PH severity on morbidity, early and late mortality in patients with pulmonary artery systolic pressure (PASP) over 30mmHg that underwent valvular heart surgery. METHODS: Retrospective observational study including all patients with PH, defined as PASP>30 mmHg that underwent isolated valvular heart surgery, between 2007 and 2016...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29688314/electrocardiographic-characteristics-anthropometric-features-and-cardiovascular-risk-factors-in-a-large-cohort-of-adolescents
#8
Massimo Santini, Stefania Angela Di Fusco, Furio Colivicchi, Alessio Gargaro
Aims: The characteristics of electrocardiographic (ECG) patterns in the general population of adolescents are insufficiently defined. The purpose of this study is to report ECG patterns and their association with anthropometric characteristics. Methods and results: Twenty-four thousand and sixty-two students of Roman schools, aged 12-19, were screened with ECG and physical examinations. Electrocardiographic abnormalities were classified as either minor/non-clinically relevant or major, and anthropometric measures were evaluated per age class...
April 23, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29669946/pravastatin-therapy-during-preeclampsia-prevents-long-term-adverse-health-effects-in-mice
#9
Nicola Garrett, Joaquim Pombo, Michelle Umpierrez, James E Clark, Mark Simmons, Guillermina Girardi
Preeclampsia (PE), associates with long-term increased risk for cardiovascular disease in women, suggesting that PE is not an isolated disease of pregnancy. It is not known if increased risk for long-term diseases is due to PE-specific factors or to prepregnancy renal and cardiovascular risk factors. We used a mouse model in which a WT female with normal prepregnancy health develops PE to investigate if preeclampsia causes long-term cardiovascular consequences after pregnancy for mothers and offspring. Mothers exhibited endothelial dysfunction and hypertension after PE and had glomerular injury that not only persisted but deteriorated, leading to fibrosis...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29652421/arterial-hypertension-after-age-65-from-epidemiology-and-pathophysiology-to-therapy-do-we-know-where-we-stand
#10
Jerzy Gąsowski, Karolina Piotrowicz, Franz H Messerli
Arterial hypertension is a prevalent disease with great harming potential. After the age of 55 years the remaining lifetime risk of hypertension amounts to 90%. Despite the constant advances some important issues such as the cut-off blood pressure for the initiation of antihypertensive therapy or the therapeutic goal are debated. In this review, we present - based on the available literature - the current concepts concerning the pathophysiology, epi-demiology and antihypertensive therapy in patients aged 65 years or older...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29620663/effects-of-a-low-salt-diet-on-isolated-systolic-hypertension-a-community-based-population-study
#11
Guo-Hong Yang, Xin Zhou, Wen-Jie Ji, Jun-Xiang Liu, Jing Sun, Rui Shi, Tie-Min Jiang, Yu-Ming Li
Evidence has shown that long-term sodium reduction can not only reduce blood pressure, but also provide cardiovascular benefits. To date, there is little evidence related to the effects of salt reduction on isolated systolic hypertension (ISH).A total of 126 hypertensive patients were divided into an ISH group (n = 51) and a non-ISH (NISH) group (n = 75). The members of each group were then randomly assigned to low sodium salt (LSSalt) or normal salt (NSalt) diets for 6 months. Their blood pressure was measured every 2 months...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29604403/slow-loaded-breathing-training-improves-blood-pressure-lung-capacity-and-arm-exercise-endurance-for-older-people-with-treated-and-stable-isolated-systolic-hypertension
#12
Chulee Ublosakka-Jones, Phailin Tongdee, Orathai Pachirat, David A Jones
BACKGROUND: Hypertension and reduced lung function are important features of aging. Slow loaded breathing training reduces resting blood pressure and the question is whether this can also improve lung function. METHODS: Thirty-two people (67 ± 5 years, 16 male) with controlled isolated systolic hypertension undertook an eight weeks randomised controlled training trial with an inspiratory load of 25% maximum inspiratory pressure (MIP) at 6 breaths per minute (slow loaded breathing; SLB) or deep breathing control (CON)...
March 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29595193/xyloketal-b-exerts-antihypertensive-effect-in-renovascular-hypertensive-rats-via-the-no-sgc-cgmp-pathway-and-calcium-signaling
#13
Li-Yan Zhao, Jie Li, Xiong-Qing Huang, Guo-Hao Wang, Xiao-Fei Lv, Wei-Feng Meng, Wen-Liang Chen, Ji-Yan Pang, Yong-Cheng Lin, Hong-Shuo Sun, Guan-Lei Wang, Yao-Min Du
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central and peripheral arteries and plays an important role in blood pressure control. In this study, we examined whether Xyl-B exerted an antihypertensive effect in a hypertensive rat model, and further explored the possible mechanisms underlying its antihypertensive action...
March 29, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29595072/platycodin-d-reverses-pathological-cardiac-hypertrophy-and-fibrosis-in-spontaneously-hypertensive-rats
#14
Yuan-Chuan Lin, Yu-Chen Lin, Wei-Wen Kuo, Chia-Yao Shen, Yi-Chang Cheng, Yueh-Min Lin, Ruey-Lin Chang, Vijaya V Padma, Chih-Yang Huang, Chih-Yang Huang
Platycodin D (PD) is the main active saponin isolated from Platycodon grandiflorum (PG) and is reported to exhibit anticancer, anti-angiogenic, anti-inflammation and anti-obesity biological effects. The current study aims to evaluate the therapeutic efficacy of PD in cardiac fibrosis and for hypertrophy in spontaneous hypertension rats (SHRs) and to verify inhibition of the signaling pathway. Significant increases in the cardiac functional indices of left ventricular internal diameter end diastole (LVIDd) and left ventricular internal diameter end systole (LVIDs); the eccentric hypertrophy marker p-MEK5; concentric hypertrophy markers, such as CaMKII[Formula: see text] and calcineurin; and expression levels of NFATc3, p-GATA4 and BNP were observed in spontaneously hypertensive groups...
March 29, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29570514/isolated-systolic-hypertension-in-the-young-a-position-paper-endorsed-by-the-european-society-of-hypertension
#15
Paolo Palatini, Enrico Agabiti Rosei, Alberto Avolio, Gregorz Bilo, Edoardo Casiglia, Lorenzo Ghiadoni, Cristina Giannattasio, Guido Grassi, Bojan Jelakovich, Stevo Julius, Giuseppe Mancia, Carmel M McEniery, Michael F O'Rourke, Gianfranco Parati, Paolo Pauletto, Giacomo Pucci, Francesca Saladini, Pasquale Strazzullo, Konstantinos Tsioufis, Ian B Wilkinson, Alberto Zanchetti
: Whether isolated systolic hypertension in the young (ISHY) implies a worse outcome and needs antihypertensive treatment is still a matter for dispute. ISHY is thought to have different mechanisms than systolic hypertension in the elderly. However, findings from previous studies have provided inconsistent results. From the analysis of the literature, two main lines of research and conceptualization have emerged. Simultaneous assessment of peripheral and central blood pressure led to the identification of a condition called pseudo or spurious hypertension, which was considered an innocent condition...
March 22, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29560354/cardiac-specific-deletion-of-pyruvate-dehydrogenase-impairs-glucose-oxidation-rates-and-induces-diastolic-dysfunction
#16
Keshav Gopal, Malak Almutairi, Rami Al Batran, Farah Eaton, Manoj Gandhi, John Reyes Ussher
Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension. As myocardial energy metabolism is altered during obesity/T2D (increased fatty acid oxidation and decreased glucose oxidation), we hypothesized that restricting myocardial glucose oxidation in lean mice devoid of the perturbed metabolic milieu observed in obesity/T2D would produce a cardiomyopathy phenotype, characterized via diastolic dysfunction...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29556793/cerebral-haemodynamics-effects-of-systemic-arterial-pulsatile-function-and-hypertension
#17
REVIEW
Alberto Avolio, Mi Ok Kim, Audrey Adji, Sumudu Gangoda, Bhargava Avadhanam, Isabella Tan, Mark Butlin
PURPOSE OF REVIEW: Concepts of pulsatile arterial haemodynamics, including relationships between oscillatory blood pressure and flow in systemic arteries, arterial stiffness and wave propagation phenomena have provided basic understanding of underlying haemodynamic mechanisms associated with elevated arterial blood pressure as a major factor of cardiovascular risk, particularly the deleterious effects of isolated systolic hypertension in the elderly. This topical review assesses the effects of pulsatility of blood pressure and flow in the systemic arteries on the brain...
March 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29552825/-antihypertensive-effect-and-mechanism-of-dendrobium-officinale-flos-on-high-blood-pressure-rats-induced-by-high-glucose-and-high-fat-compound-alcohol
#18
Kai-Lun Liang, Ping Fang, Qiu-Qiu Shi, Jie Su, Bo Li, Su-Hong Chen, Gui-Yuan Lv
This study aimed to investigate the antihypertensive effect and possible mechanism of Dendrobium officinale flos on hypertensive rats induced by high glucose and high fat compound alcohol. The hypertensive models were successfully made by high-glucose and high-fat diet, with gradient drinking for 4 weeks, and then divided into model control group, valsartan (5.7 mg·kg⁻¹) positive control group and D. officinale flos groups (3,1 g·kg⁻¹). After 6 weeks of treatment, the blood pressure of rats was measured regularly...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29541995/association-of-hypertension-body-mass-index-and-waist-circumference-with-fluoride-intake-water-drinking-in-residents-of-fluoride-endemic-areas-iran
#19
Mahmood Yousefi, Mehdi Yaseri, Ramin Nabizadeh, Elham Hooshmand, Mohsen Jalilzadeh, Amir Hossein Mahvi, Ali Akbar Mohammadi
Hypertension is becoming a global epidemic for both rural and urban populations; it is a major public health challenge in Iran. Fluoride can be a risk factor for hypertension. Cross-sectional analysis was conducted in two study areas to assess the relation of fluoride with blood pressure prevalence, BMI, waist circumference, and waist-to-hip ratio (WHR) among different age groups in both sexes. The mean value of fluoride concentration in the drinking water from the four study villages varied from 0.68 to 10...
March 14, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29502094/cushing-s-sign-and-severe-traumatic-brain-injury-in-children-after-blunt-trauma-a-nationwide-retrospective-cohort-study-in-japan
#20
Tetsuya Yumoto, Hiromichi Naito, Takashi Yorifuji, Hiroki Maeyama, Yoshinori Kosaki, Hirotsugu Yamamoto, Kohei Tsukahara, Takaaki Osako, Atsunori Nakao
OBJECTIVE: We tested whether Cushing's sign could predict severe traumatic brain injury (TBI) requiring immediate neurosurgical intervention (BI-NSI) in children after blunt trauma. DESIGN: Retrospective cohort study using Japan Trauma Data Bank. SETTING: Emergency and critical care centres in secondary and tertiary hospitals in Japan. PARTICIPANTS: Children between the ages of 2 and 15 years with Glasgow Coma Scale motor scores of 5 or less at presentation after blunt trauma from 2004 to 2015 were included...
March 3, 2018: BMJ Open
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