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https://www.readbyqxmd.com/read/28926879/-systematic-evaluation-on-effectiveness-and-safety-of-recombinant-human-growth-hormone-in-treating-adult-patients-with-severe-burn
#1
F Y Tian, B Wu, T Xu, X H Jiang
Objective: To systcmatically evaluate the effectiveness and safety of recombinant human growth hormone (rhGH) in treating adults with severe burn. Methods: Databases including PubMed, Cochrane Library, and Embase were searched using key words " burns, thermal, human growth hormone, growth hormone, hGH, and somatropin (human)" , and China Biology Medicine disc, Chinese Journals Full-text Database, VIP Database, and Wanfang Database were searched using key words in Chinese version "," to obtain the randomized controlled trials about rhGH in the treatment of adults with severe burn from the establishment of each database to December 2016...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28926857/the-amelioration-of-insulin-resistance-in-salt-loading-subjects-by-potassium-supplementation-is-associated-with-a-reduction-in-plasma-il-17a-levels
#2
Wen Wen, Zhaofei Wan, Dong Zhou, Juan Zhou, Zuyi Yuan
Background High dietary salt intake contributes to the development of autoimmune/inflammatory diseases including metabolic syndrome (MetS) which potassium supplementation can potentially reverse. T helper (Th) 17 cells as well as its production interleukin (IL)-17A are involved in the pathogenesis of MetS. The polarization of Th17 cells and enhanced IL-17A production induced by high salt might increase the risk of autoimmune/inflammatory diseases. Methods 45 normotensive subjects (aged 29 to 65 years) were enrolled from a rural community of Northern China at random...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28925763/clinical-significance-of-soluble-intercellular-adhesion-molecule-1-and-interleukin-6-in-patients-with-extrahepatic-cholangiocarcinoma
#3
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Yasuhide Kofunato, Ryo Okada, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Shigeru Marubashi, Koji Kono, Seiichi Takenoshita
Purpose/Aim: Although several prognostic factors for extrahepatic cholangiocarcinoma (EHC) have been reported, preoperative prognostic factors have yet to be established. We investigated the serum concentration of angiogenic, inflammatory, and nutritional parameters. MATERIALS AND METHODS: Twenty-five patients with EHC were enrolled before starting treatment. Preoperative prognostic factors were identified using multivariate analyses. RESULTS: The serum soluble intercellular adhesion molecule-1 (sICAM-1) levels were significantly higher in the patients with EHC (436...
September 19, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28925397/coactosin-like-protein-clp-cotl1-suppresses-breast-cancer-growth-through-activation-of-il-24-perp-and-inhibition-of-non-canonical-tgf%C3%AE-signaling
#4
L Xia, X Xiao, W L Liu, Y Song, T J J Liu, Y J Li, E Zacksenhaus, X J Hao, Y Ben-David
Coactosin-like protein (CLP, or Cotl1), is an F-actin-binding protein, whose role in cancer is largely unknown. Here we show that CLP/Cotl1 is highly expressed in a rat epithelial breast cancer cell line (FE1.3) compared with its mesenchymal counterpart (FE1.2). Knockdown of CLP/Cotl1 in FE1.3 cells increased cell proliferation, whereas its overexpression in FE1.2 cells inhibited proliferation in culture and reduced tumor growth in xenograft assays in mice. Mechanistically, we identified two major pathways through which CLP/Cotl1 exerts its suppressive effects...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28923247/effects-of-plant-and-animal-based-high-fat-diets-on-lipid-storage-and-distribution-in-environmental-bacteria-colonized-gnotobiotic-mice
#5
Yi-Hsun Chen, Chien-Chao Chiu, Shao-Wen Hung, Ju-Yun Liu, Yu-Chih Wang, Qiang Lv, Cheng-Chih Hsu, Yi-Wen Huang, Wen-Ching Huang, Hsiao-Li Chuang, Ter-Hsin Chen
Different edible oils such as lard and soybean oil have been reported to interact with the gut microbiota, affecting host lipid metabolism. However, whether bacteria derived from the environment influence host lipid metabolism remains unclear. This study aimed to clarify the roles of environmental bacteria in host lipid storage and distribution with various edible oils. Gnotobiotic C57BL/6JNarl mice were inoculated with Lysinibacillus xylanilyticus and Paenibacillus azoreducens and then fed either a normal diet (LabDiet 5010, control group) or a diet containing 60% lard (L-group) or soybean oil (S-group) for 18 months...
September 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28923120/high-dose-interleukin-2-hd-il-2-for-advanced-melanoma-a-single-center-experience-from-the-university-of-pittsburgh-cancer-institute
#6
Diwakar Davar, Fei Ding, Melissa Saul, Cindy Sander, Ahmad A Tarhini, John M Kirkwood, Hussein A Tawbi
BACKGROUND: Durable remissions are observed in a fraction of metastatic melanoma patients treated with high-dose interleukin-2 (HD IL-2). Early studies reported overall (OR) and complete response (CR) rates of 16% and 8% respectively. Toxicity limited use to specialized centers with standardized protocols. We report on 243 patients treated at the University of Pittsburgh in a non-intensive care unit (ICU) oncology specialty setting. METHODS: Clinical and radiological data were collected on 243 patients treated between 1992 and 2015...
September 19, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28922096/the-effects-of-ramadan-fasting-on-body-composition-blood-pressure-glucose-metabolism-and-markers-of-inflammation-in-nafld-patients-an-observational-trial
#7
Fereshteh Aliasghari, Azimeh Izadi, Bahram Pourghassem Gargari, Sara Ebrahimi
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and is a serious global health problem. Regarding the increasing prevalence of NAFLD, finding various strategies to prevent and manage the disease is of great importance. The aim of this study was to determine the effects of caloric restriction during Ramadan fasting on anthropometric indices, fasting glucose, plasma insulin, insulin resistance, and inflammatory cytokines (C-reactive protein and interleukin 6) in patients with NAFLD...
September 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28921468/inflammasomes-in-the-gut-mucosal-homeostasis
#8
Xiaomin Yao, Guangxun Meng
Inflammasomes are critical checkpoints in inflammation. The activation of inflammasome can cause a series of inflammatory responses including maturation of interleukin (IL)-1β and IL-18 and a specialized form of cell death called pyroptosis. Since its identification in the early 2000s, inflammasomes have been implicated to play multifaceted roles in varied pathological and physiological conditions, especially in the mucosal compartments including the gut. Maintaining gut mucosal homeostasis has always been a remarkable challenge for the host due to both the vast mucosal surface that is exposed to the outside and the enormous amount of local microbiota...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28919544/increased-level-of-interleukin-6-associates-with-increased-90-day-and-1-year-mortality-in-patients-with-end-stage-liver-disease
#9
Johannes Remmler, Christoph Schneider, Theresa Treuner-Kaueroff, Michael Bartels, Daniel Seehofer, Markus Scholz, Thomas Berg, Thorsten Kaiser
BACKGROUND & AIMS: Organ allocation for liver transplantation is based on prognosis, using the model for end-stage liver disease (MELD) or MELD-Na score. These scores do not consider systemic inflammation and septic complications. Blood level of C-reactive protein (CRP), in addition to the MELD score, associates with mortality in patients with end-stage liver disease, whereas levels of interleukin 6 (IL6) have not been systematically studied. METHODS: We performed a retrospective observational cohort study of 474 patients with end-stage liver disease (63...
September 14, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28918754/macrophage-activation-like-syndrome-an-immunological-entity-associated-with-rapid-progression-to-death-in-sepsis
#10
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J Giamarellos-Bourboulis
BACKGROUND: A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis. METHODS: Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704)...
September 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28918609/associations-among-gastric-juice-ph-atrophic-gastritis-intestinal-metaplasia-and-helicobacter-pylori-infection
#11
Jihee Sung, Nayoung Kim, Jongchan Lee, Young-Jae Hwang, Hyoung Woo Kim, Jung Wha Chung, Jin-Wook Kim, Dong Ho Lee
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio and interleukin (IL)-1β levels were measured...
September 19, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28918467/anisodamine-inhibits-endoplasmic-reticulum-stress-associated-txnip-nlrp3-inflammasome-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#12
Xiaopeng Yuan, Yitao Zheng, Chuanbao Chen, Changxi Wang
Anisodamine protects against free radical-induced cellular damage. This study aimed to investigate the protective effect of anisodamine on rhabdomyolysis-induced acute kidney injury (RIAKI). C57BL/6 J mice, TXNIP(-/-) and NLRP3 (-/-) (both were C57BL/6 J background) mice were used to construct RIAKI model. Anisodamine administration was performed on RIAKI mice only. Mice were divided into control, TXNIP-KD (knock down), LNPR3-KD, and anisodamine group (n = 15 in each group). The renal injury, renal function, renal tubular cells apoptosis and expression of Caspase-1, ASC, endoplasmic reticulum (ER) stress markers IRE-1α, CHOP, and ATF4, and interleukin (IL-1α, IL-1β, and IL-18) were detected...
September 16, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28916975/flaxseed-oil-supplementation-improve-gene-expression-levels-of-ppar-%C3%AE-lp-a-il-1-and-tnf-%C3%AE-in-type-2-diabetic-patients-with-coronary-heart-disease
#13
Ali Akbar Hashemzadeh, Nikoo Nasoohi, Fariba Raygan, Esmat Aghadavod, Elmira Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
This study was carried out to determine the effects of flaxseed oil administration on gene expression levels related to insulin, lipid and inflammation in overweight diabetic patients with coronary heart disease (CHD). This randomized double-blind, placebo-controlled trial was conducted among 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to intake either 1000 mg n-3 fatty acid from flaxseed oil containing 400 mg α-Linolenic acid [ALA (18:3n-3)] (n = 30) or placebo (n = 30) twice a day for 12 weeks...
September 15, 2017: Lipids
https://www.readbyqxmd.com/read/28915449/increased-expression-of-nlrp3-inflammasome-in-placentas-from-pregnant-women-with-severe-preeclampsia
#14
Ingrid C Weel, Mariana Romão-Veiga, Mariana L Matias, Eduardo G Fioratti, Jose C Peraçoli, Vera T Borges, João P Araujo, Maria T Peraçoli
Preeclampsia is a pregnancy disorder characterized by imbalance between pro- and anti-inflammatory cytokines associated with high plasma levels of uric acid and Interleukin-1 beta (IL-1β). The inflammasome is a protein complex that mediates innate immune responses via caspase-1 activation promoting secretion of IL-1β and IL-18 in their active forms, and also release of the high-mobility group box 1 protein (HMGB1). As the placenta seems to play an important role in the pathogenesis of PE, the present study investigated the expression of genes and proteins related to the inflammasome in placentas from pregnant women with severe preeclampsia...
September 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28915273/longitudinal-co-variations-between-inflammatory-cytokines-lung-function-and-patient-reported-outcomes-in-patients-with-asthma
#15
Karin Lodin, Mats Lekander, Jörgen Syk, Kjell Alving, Predrag Petrovic, Anna Andreasson
BACKGROUND: Asthma is a chronic inflammatory respiratory disorder associated with reduced lung function and poor quality of life. The condition is also associated with poor self-rated health, a major predictor of objective health trajectories. Of biological correlates to self-rated health, evidence suggests a role for inflammatory cytokines and related sickness behaviours. However, this is mainly based on cross-sectional data, and the relation has not been investigated in patients with chronic inflammatory conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28910918/-advances-in-the-role-of-interleukin-18-in-acute-respiratory-distress-syndrome
#16
W Tan, P Jiang
No abstract text is available yet for this article.
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28906456/effects-of-%C3%AE-glucans-ingestion-on-alveolar-bone-loss-intestinal-morphology-systemic-inflammatory-profile-and-pancreatic-%C3%AE-cell-function-in-rats-with-periodontitis-and-diabetes
#17
Viviam de O Silva, Raquel V Lobato, Eric F Andrade, Débora R Orlando, Bruno D B Borges, Márcio G Zangeronimo, Raimundo V de Sousa, Luciano J Pereira
This study aimed to evaluate the effects of β-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic β-cell function (HOMA-BF) in diabetic rats with periodontal disease (PD). Besides, intestinal morphology was determined by the villus/crypt ratio. A total of 48 Wistar rats weighing 203 ± 18 g were used. Diabetes was induced by the intraperitoneal injection of streptozotocin (80 mg/kg) and periodontal inflammation, by ligature...
September 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28905319/pi3k-inhibition-protects-mice-from-nafld-by-down-regulating-cmklr1-and-nlrp3-in-kupffer-cells
#18
Wenfeng Zhang, Yan Liu, Mingbing Wu, Xiwen Zhu, Tao Wang, Kun He, Peizhi Li, Xiaoling Wu
Inflammation induced by high-fat diet (HFD) is of critical importance in the development of hepatic steatosis. The role of chemerin in the progress of nonalcoholic fatty liver disease (NAFLD) remains controversial. Here, we have evaluated the effects and mechanism of chemerin on insulin sensitivity and inflammation. An inhibitor (wortmannin) and agonist (insulin-like growth factor 1 (IGF-1) of phosphatidyl inositol 3-kinase (PI3K) were applied to Kupffer cells (KCs) after treatment with a concentration gradient of chemerin in vitro...
September 13, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28904432/impact-of-steroids-on-the-inflammatory-response-after-ischemic-acute-kidney-injury-in-rats
#19
J Fontana, A Vogt, A Hohenstein, U Vettermann, E Doroshenko, E Lammer, B A Yard, S Hoeger
Inflammation plays a crucial role in acute kidney injury (AKI). The current study was designed to analyze the influence of prednisolone treatment on the inflammatory reaction during the first 96 h after AKI induction in a rat model. AKI was induced by unilateral clipping of the renal vessels. The treatment group received prednisolone 5 mg/kg s.c. daily. Infiltration rates of macrophages, leukocytes, and T-cells (24, 96 h) as well as plasma concentrations of the inflammatory markers intercellular adhesion molecule, interleukin-1 beta (IL-1β), IL-18, IL-6, and tumor necrosis factor-alpha (0, 6, 24, 96 h) were determined by fluorescence-activated cell sorting (FACS) analysis only...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28904431/role-of-gut-derived-uremic-toxins-on-oxidative-stress-and-inflammation-in-patients-with-chronic-kidney-disease
#20
S Gouroju, P V L N Srinivasa Rao, A R Bitla, K S Vinapamula, S M Manohar, S Vishnubhotla
Several cardiovascular disease (CVD) risk factors have been identified among patients with chronic kidney disease (CKD). Gut-derived uremic toxins (GDUT) are important modifiable contributors in this respect. There are very few Indian studies on GDUT changes in CKD. One hundred and twenty patients older than 18 years diagnosed with CKD were enrolled along with forty healthy subjects. The patients were classified into three groups of forty patients based on stage of CKD. Indoxyl sulfate (IS), para cresyl sulfate (p-CS), indole acetic acid (IAA), and phenol were estimated along with the assessment of oxidative stress (OS), inflammatory state, and bone mineral disturbance...
September 2017: Indian Journal of Nephrology
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