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https://www.readbyqxmd.com/read/29222937/preoperative-t1-slope-as-a-predictor-of-change-in-cervical-alignment-and-range-of-motion-after-cervical-disc-arthroplasty
#1
Jianhui Zhao, Rui Jiang, Yuhui Yang, Rui Gu, Zhongli Gao, Jianlin Xiao, Shangjun Chen, Modi Yang
BACKGROUND This study analyzed the effect of preoperative T1 slope on cervical alignment and range of motion (ROM) after cervical disc arthroplasty (CDA) in patients with cervical degenerative disease. MATERIAL AND METHODS This retrospective study included 32 patients with single-level symptomatic cervical disc disease who underwent CDA with the Mobi-C cervical disc prosthesis and had a mean follow-up of 26.8±6.4 months. Standing lateral, flexion, and extension X-rays of the cervical spine were obtained preoperatively and postoperatively at 24-month follow-up...
December 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29222782/diolistic-labeling-and-analysis-of-dendritic-spines
#2
M Foster Olive, Armani P Del Franco, Cassandra D Gipson
Dendritic spines are diverse and plastic components of the neuronal cell apparatus and are highly responsive to trophic factors during both development and adulthood. Diolistic labeling of neurons with lipophilic fluorescent dyes, coupled with advanced high-resolution microscopy methods, provides robust labeling of dendritic spines for assessment of their density and morphology. Here, we describe a method for labeling of dendritic spines using diolistic labeling in ex vivo brain slices, visualization using confocal laser scanning microscopy, deconvolution, and analysis using the Surpass module of Bitplane Imaris software...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222730/morphology-and-morphometry-of-lacrimal-drainage-system-in-relation-to-bony-landmarks-in-caucasian-adults-a-cadaveric-study
#3
Mohammad Javed Ali, Martin Schicht, Friedrich Paulsen
PURPOSE: The objective of this study is to examine the morphometry of the lacrimal drainage system with reference to bony landmarks in the vicinity. METHODS: Twenty midsaggitalized heads obtained from sixteen preserved cadavers were studied. Measurements involved detailed morphometry of anterior and posterior lacrimal crests, bony lacrimal sac fossa, entrance and length of the bony nasolacrimal duct (NLD), attachment of Horner's muscle, and characteristics of the inferior meatal opening of the NLD...
December 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29222688/comparison-of-qualitative-and-quantitative-ct-and-mri-parameters-for-monitoring-of-longitudinal-spine-involvement-in-patients-with-multiple-myeloma
#4
M Horger, J Fritz, W M Thaiss, H Ditt, K Weisel, M Haap, Christopher Kloth
PURPOSE: To compare qualitative and quantitative computed tomography (CT) and magnetic resonance imaging (MRI) parameters for longitudinal disease monitoring of multiple myeloma (MM) of the axial skeleton. MATERIALS AND METHODS: We included 31 consecutive patients (17 m; mean age 59.20 ± 8.08 years) with MM, who underwent all baseline (n = 31) and at least one or more (n = 47) follow-up examinations consisting of multi-parametric non-enhanced whole-body MRI (WBMRI) and non-enhanced whole-body reduced-dose thin-section MDCT (NEWBMDCT) between 06/2013 and 09/2016...
December 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29222205/novel-use-of-a-trabecular-metal-spacer-in-the-treatment-of-a-long-standing-ulnar-fracture-non-union
#5
Oluwatobi O Onafowokan, Julian S H Gaskin, Rory G Middleton, Mark R Norton
The use of trabecular metal (TM) implants in spine and joint surgery is well documented. However, their use has yet to be reported as an alternative to either allograft or autograft in the management of fracture non-unions. We present our experience in using a TM implant for treating a patient with a long-standing ulnar fracture non-union. Excision of devitalised bone resulted in a 17 mm defect which the TM implant was used to infill. The defect was then bridged with a locking plate. At 2-year clinical and radiographic review, bony union and a pain-free return to full function was noted...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221679/the-gnathobasic-spine-microstructure-of-recent-and-silurian-chelicerates-and-the-cambrian-artiopodan-sidneyia-functional-and-evolutionary-implications
#6
Russell D C Bicknell, John R Paterson, Jean-Bernard Caron, Christian B Skovsted
Gnathobasic spines are located on the protopodal segments of the appendages of various euarthropod taxa, notably chelicerates. Although they are used to crush shells and masticate soft food items, the microstructure of these spines are relatively poorly known in both extant and extinct forms. Here we compare the gnathobasic spine microstructures of the Silurian eurypterid Eurypterus tetragonophthalmus from Estonia and the Cambrian artiopodan Sidneyiainexpectans from Canada with those of the Recent xiphosuran chelicerate Limulus polyphemus to infer potential variations in functional morphology through time...
December 5, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29220208/changing-utilization-of-noninvasive-diagnostic-imaging-over-2-decades-an-examination-family-focused-analysis-of-medicare-claims-using-the-neiman-imaging-types-of-service-categorization-system
#7
David A Rosman, Richard Duszak, Wenyi Wang, Danny R Hughes, Andrew B Rosenkrantz
OBJECTIVE: The objective of our study was to use a new modality and body region categorization system to assess changing utilization of noninvasive diagnostic imaging in the Medicare fee-for-service population over a recent 20-year period (1994-2013). MATERIALS AND METHODS: All Medicare Part B Physician Fee Schedule services billed between 1994 and 2013 were identified using Physician/Supplier Procedure Summary master files. Billed codes for diagnostic imaging were classified using the Neiman Imaging Types of Service (NITOS) coding system by both modality and body region...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29219781/a-novel-duraplasty-technique-following-fenestration-of-a-massive-lumbar-arachnoid-cyst-in-a-patient-with-scoliosis-technical-case-report
#8
Matthew T Neal, Randall J Hlubek, Alexander E Ropper, U Kumar Kakarla
When a dural defect is encountered during spine surgery, the dura mater must be reconstituted to minimize the occurrence of minor or major life-threatening sequelae. The neurosurgical literature lacks strategies for managing large dural defects encountered during surgery. The authors describe a 24-year-old man who developed cauda equina syndrome secondary to altered CSF flow in a large thoracolumbar arachnoid cyst. Surgical decompression and fenestration of the arachnoid cyst were performed, and the large dural defect was treated using a multilayer closure with collagen matrix, titanium mesh, and methylmethacrylate...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29219780/anatomical-and-technical-factors-associated-with-superior-facet-joint-violation-in-lumbar-fusion
#9
Alisson R Teles, Michael Paci, Gabriel Gutman, Fahad H Abduljabbar, Jean A Ouellet, Michael H Weber, Jeff D Golan
OBJECTIVE The aim of this study was to evaluate the anatomical and surgical risk factors for screw-related facet joint violation at the superior level in lumbar fusion. METHODS The authors conducted a retrospective review of a consecutive series of posterior lumbar instrumented fusions performed by a single surgeon. Inclusion criteria were primary lumbar fusion of 1 or 2 levels for degenerative disorders. The following variables were analyzed as possible risk factors: surgical technique (percutaneous vs open screw placement), depth of surgical field, degree of anterior slippage of the superior level, pedicle and facet angle, and facet degeneration of the superior level...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29219779/metastases-of-spinal-myxopapillary-ependymoma-unique-characteristics-and-clinical-management
#10
Theresa Kraetzig, Lily McLaughlin, Mark H Bilsky, Ilya Laufer
OBJECTIVE Myxopapillary ependymoma is a benign WHO Grade I tumor most commonly located in the conus-cauda equina region of the spine. Although this tumor is defined by an overall excellent survival, dissemination throughout the whole neuraxis occurs frequently. The current study evaluated the clinical characteristics and significance of myxopapillary ependymoma metastases. METHODS Patients who underwent surgery from 2005 to 2015 for treatment of spinal myxopapillary ependymoma were included in the study. Charts were reviewed for primary tumor symptoms and initial treatment, local recurrence, response to salvage therapy, and presence and behavior of distant metastases...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29218848/shank1-is-differentially-expressed-during-development-in-ca1-hippocampal-neurons-and-astrocytes
#11
Sean M Collins, Amogh P Belagodu, Samantha L Reed, Roberto Galvez
Recent studies have strongly suggested a role for the synaptic scaffolding protein SHANK1 in normal synaptic structure and signaling. Global SHANK1 knockout (SHANK1-/-) mice demonstrate reduced dendritic spine density, an immature dendritic spine phenotype and impairments in various cognitive tasks. SHANK1 overexpression is associated with increased dendritic spine size and impairments in fear conditioning. These studies suggest proper regulation of SHANK1 is crucial for appropriate synaptic structure and cognition...
December 8, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29218502/lower-preoperative-hounsfield-unit-values-are-associated-with-intra-operative-fractures-in-cementless-bipolar-hemiarthroplasty
#12
Seung-Ju Kim, Hyun-Soo Park, Dong-Woo Lee, Jong Hun Kim
The use of Hounsfield units (HU) from CT scanning to assess regional BMD has been described. Therefore, we evaluated whether HU could be used to identify osteoporosis of the proximal part of the femur. The results showed that HU assessment is associated with the presence of intra-operative fracture during arthroplasty. INTRODUCTION: The aim with this study was to determine the association of preoperative Hounsfield unit (HU) in hip computed tomography (CT) with intra-operative osteoporotic fracture during cementless hemiarthroplasty...
December 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29218483/asymmetrical-trunk-movement-during-walking-improved-to-normal-range-at-3%C3%A2-months-after-corrective-posterior-spinal-fusion-in-adolescent-idiopathic-scoliosis
#13
Daniel A C F Wong-Chung, Janneke J P Schimmel, Marinus de Kleuver, Noël L W Keijsers
PURPOSE: To investigate the effects of posterior spinal fusion (PSF) and curve type on upper body movements in Adolescent Idiopathic Scoliosis (AIS) patients during gait. METHODS: Twenty-four girls (12-18 years) with AIS underwent PSF. 3D-Gait-analyses were performed preoperatively, at 3 months and 1 year postoperatively. Mean position (0° represents symmetry) and range of motion (ROM) of the trunk (thorax-relative-to-pelvis) in all planes were assessed. Lower body kinematics and spatiotemporal parameters were also evaluated...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29218482/a-novel-muscle-sparing-high-thoracotomy-for-upper-thoracic-spine-resection-and-reconstruction
#14
Derek T Bernstein, Wu Zhuge, Shanda H Blackmon, Rex A W Marco
PURPOSE: High thoracotomy allows access to the anterior cervicothoracic and upper thoracic vertebrae; however, traditional techniques transect shoulder girdle muscles, leading to postoperative shoulder dysfunction. Muscle-sparing techniques diminish this concern, but often sacrifice the quality of exposure. We describe a novel muscle-sparing, high thoracotomy approach for the treatment of ventral cervicothoracic and upper thoracic spine lesions. METHODS: A novel muscle-sparing, high thoracotomy approach is described, utilizing a midline posterior incision with lateral extension from the lateral decubitus position...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29218392/unusual-circumstances-to-diagnose-cervical-pott-s-disease
#15
Mohamed Ali Kedous, Ahmed Msakni, Wael Chebbi, Mourad Zaraa, Mohsen Trabelsi
Tuberculous spondylodiscitis usually affects the dorso-lumbar spine, and its cervical location is a rare condition that can mimic other diseases and consequently cause treatment delays. We report a case of tuberculous spondylodiscitis of the lower cervical spine discovered under unusual circumstances in a patient with severe polytrauma involving a cranio-cerebral trauma, a non-displaced fracture of the two laminæ and the spinous process of the C6 vertebrae as well as fibular and tibial shaft fractures. The patient underwent static tibial nailing, and a collar with occipital and chin supports was applied...
December 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29217824/soluble-tau-has-devastating-effects-on-the-structural-plasticity-of-hippocampal-granule-neurons
#16
M Bolós, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J Ávila, M Llorens-Martín
Tau is a neuronal microtubule-associated protein with countless physiological functions. Although the detrimental effects of insoluble aggregated Tau have been widely studied, recent evidence supports the notion that soluble Tau (composed mostly of monomers and dimers) is also toxic for neurons. Here we evaluated the long-term impact of a single stereotaxic injection of human soluble Tau on hippocampal granule neurons in mice. At the ultrastructural level, soluble Tau reduced the number of afferent synapses and caused a dramatic depletion of synaptic vesicles both in afferent and efferent synapses...
December 8, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29217476/sumo1-impact-on-alzheimer-disease-pathology-in-an-amyloid-depositing-mouse-model
#17
Erin Knock, Shinsuke Matsuzaki, Hironori Takamura, Kanayo Satoh, Grace Rooke, Kyung Han, Hong Zhang, Agnieszka Staniszewski, Taiichi Katayama, Ottavio Arancio, Paul E Fraser
Small ubiquitin-related modifiers (SUMOs) conjugated or bound to target proteins can affect protein trafficking, processing and solubility. SUMOylation has been suggested to play a role in the amyloid plaque and neurofibrillary tangle pathology of Alzheimer disease (AD) and related neurodegenerative diseases. The current study examines the impact of SUMO1 on processing of the amyloid precursor protein (APP) leading to the production and deposition of the amyloid-β (Aβ) peptide. An in vivo model of these pathways was developed by the generation of double transgenic mice over-expressing human SUMO1 and a mutant APP...
December 4, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29217331/dosimetric-impact-of-translational-and-rotational-setup-errors-for-spine-stereotactic-body-radiotherapy-a-phantom-study
#18
Makoto Sasaki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Manabu Nakata, Masahiro Hiraoka
This study aimed to investigate experimentally the effect of translational and rotational setup errors on 3-dimensional dose distributions by using the gamma index and dose volumetric indices for spine stereotactic body radiotherapy. Treatment plans were designed in accordance with the Radiation Therapy Oncology Group (RTOG) 0631 protocol. Measurements were taken using a Delta4 phantom (ScandiDos, Uppsala, Sweden). Setup errors were generated using the HexaMotion 6D moving platform (ScandiDos). Dose distributions in the presence of setup errors were evaluated, according to the γ passing rate with the 3% and 2 mm criteria (γ3%/2 mm) and dose volumetric indices (D90 for the target volume and D2 for the spinal cord), using the Delta4 device (ScandiDos)...
December 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29217293/an-evaluation-of-two-types-of-exercise-classes-containing-shoulder-exercises-or-a-combination-of-shoulder-and-thoracic-exercises-for-the-treatment-of-nonspecific-shoulder-pain-a-case-series
#19
Eva Barrett, Carmela Conroy, Marie Corcoran, Kieran O' Sullivan, Helen Purtill, Jeremy Lewis, Karen McCreesh
STUDY DESIGN: A case series was carried out. INTRODUCTION: There is a lack of evidence exploring the effectiveness of group exercise classes for people with nonspecific shoulder pain (NSSP). Also, there is a lack of research that measures potential reductions in thoracic kyphosis after exercise interventions in people with NSSP. PURPOSE OF THE STUDY: To observe changes in shoulder pain, disability, and thoracic kyphosis in 2 groups of people with NSSP, after 2 different types of group exercise classes...
December 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29216909/which-measuring-site-in-ankylosing-spondylitis-is-best-to-detect-bone-loss-and-what-predicts-the-decline-results-from-a-5-year-prospective-study
#20
Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T Jacobsson, Helena Forsblad-d'Elia
BACKGROUND: Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine anterior-posterior (AP) projection may be difficult to interpret due to the ligamentous calcifications, and the lateral projection might be a better measuring site. Our objectives were to investigate BMD changes after 5 years at different measuring sites in patients with AS and to evaluate disease-related variables and medications as predictors for BMD changes...
December 8, 2017: Arthritis Research & Therapy
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