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https://www.readbyqxmd.com/read/28108780/cement-augmented-screws-in-a-cervical-two-level-corpectomy-with-anterior-titanium-mesh-cage-reconstruction-a-biomechanical-study
#1
Sebastian Hartmann, Claudius Thomé, Anja Tschugg, Johannes Paesold, Pujan Kavakebi, Werner Schmölz
STUDY DESIGN: Biomechanical investigation. PURPOSE: Cervical two-level corpectomies with anterior-only instrumentation are associated with a high rate of implant-related complications. These procedures, therefore, often require an additional dorsal instrumentation to prevent screw loosening. Cement augmentation of the anterior screws in two-level corpectomies might stabilize the construct, so that a second dorsal procedure could be avoided. To evaluate the screw anchorage in cervical anterior-only procedures, an ex vivo evaluation of the range of motion (ROM) in two-level corpectomies (C4 and C5), with and without cement augmentation of the anterior screws, was carried out in this study...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28108498/mglur2-versus-mglur3-metabotropic-glutamate-receptors-in-primate-dorsolateral-prefrontal-cortex-postsynaptic-mglur3-strengthen-working-memory-networks
#2
Lu E Jin, Min Wang, Veronica C Galvin, Taber C Lightbourne, Peter Jeffrey Conn, Amy F T Arnsten, Constantinos D Paspalas
The newly evolved circuits in layer III of primate dorsolateral prefrontal cortex (dlPFC) generate the neural representations that subserve working memory. These circuits are weakened by increased cAMP-K(+) channel signaling, and are a focus of pathology in schizophrenia, aging, and Alzheimer's disease. Cognitive deficits in these disorders are increasingly associated with insults to mGluR3 metabotropic glutamate receptors, while reductions in mGluR2 appear protective. This has been perplexing, as mGluR3 has been considered glial receptors, and mGluR2 and mGluR3 have been thought to have similar functions, reducing glutamate transmission...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108406/berry-s-ligament-and-the-inferior-thyroid-artery-as-reliable-anatomical-landmarks-for-the-recurrent-laryngeal-nerve-a-fresh-cadaveric-study-of-the-cervical-spine-the-recurrent-laryngeal-nerve-rln-relevant-to-spine
#3
Ali Rajabian, Michael Walsh, Nasir A Quraishi
BACKGROUND CONTEXT: Whilst most cadaveric studies of the RLN have focused on course variations, they have usually been done on preserved (fixed and embalmed) cadavers which renders the RLN immobile and of less surgical landmark value. PURPOSE: Our aim was to perform a thorough exposure in fresh cadavers with the intention of investigating inferior thyroid artery and Berry's ligament as reliable landmarks for the identification of the RLN in anterior cervical spine surgery...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28108405/defects-of-the-vertebral-endplate-implications-for-disc-degeneration-depend-on-size
#4
Uruj Zehra, Luke Flower, Katharine Robson-Brown, Michael A Adams, Patricia Dolan
BACKGROUND CONTEXT: Bony vertebral endplates must be porous to allow metabolite transport into the disc, and yet strong to resist high intradiscal pressure. Endplate defects may therefore have nutritional and mechanical consequences for the disc, depending on their size and type. We hypothesise that broad, diffuse defects are more closely associated with disc decompression and degeneration than are focal Schmorl's node-type defects. PURPOSE: To determine how the size and type of endplate defects are related to decompression and degeneration in the adjacent intervertebral disc...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28108404/annulus-fibrosus-cells-express-and-utilize-c-c-chemokine-receptor-5-ccr5-for-migration
#5
Weijun Liu, David Liu, Justin Zheng, Peng Shi, Po-Hsin Chou, Chundo Oh, Di Chen, Howard S An, Ana Chee
BACKGROUND CONTEXT: Disc degeneration is associated with the progressive loss of the proteoglycan content of the intervertebral disc (IVD), decreased matrix synthesis, higher concentrations of proteolytic enzymes and increased levels of pro-inflammatory cytokines. In previous studies, we have shown that C-C chemokine ligand (CCL)2, CCL3, and CCL5 are highly expressed by cultured nucleus pulposus (NP) and annulus fibrosus (AF) cells that have been treated by interleukin (IL)-1. The major function for these chemokines is to recruit immune cells into the disc...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28108403/risk-of-cement-leakage-and-pulmonary-embolism-by-bone-cement-augmented-pedicle-screw-fixation-of-the-thoracolumbar-spine
#6
Insa Janssen, Yu-Mi Ryang, Jens Gempt, Stefanie Bette, Julia Gerhardt, Jan Kirschke, Bernhard Meyer
BACKGROUND: Cement augmented pedicle screw instrumentation (CAPSI) of the thoracolumbar spine is indicated in osteoporosis or osteopenia to improve pullout strength and biomechanical stability of pedicle screws (PS). Only few studies report on the incidence of pulmonary cement embolism or other complications associated with CAPSI. PURPOSE: Aim of this retrospective study was to assess the rate of CAPSI associated complications. STUDY DESIGN: Retrospective cohort study...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28108319/how-the-changes-in-the-system-affect-trauma-care-provision-the-assessment-of-and-implications-for-lithuanian-trauma-service-performance-in-2007-2012
#7
Žilvinas Dambrauskas, Vytautas Aukštakalnis, Aurika Karbonskienė, Dmitrijus Kačiurinas, Jolanta Vokietienė, Robertas Lapka, Algimantas Pamerneckas, Narūnas Porvaneckas, Kęstutis Stašaitis, Nedas Jasinskas, Paulius Dobožinskas, Dinas Vaitkaitis, Raimundas Lunevičius
OBJECTIVE: The aim of this study was to identify and assess the effects of changes in the Lithuanian trauma service from 2007 to 2012. We postulate that the implications derived from this study will be of importance to trauma policy planners and makers in Lithuania and throughout other countries of Eastern and Central Europe. MATERIALS AND METHODS: Out of 10,390 trauma admissions to four trauma centers in 2007, 294 patients (2.8%) were randomly selected for the first arm of a representative study sample...
January 6, 2017: Medicina
https://www.readbyqxmd.com/read/28108084/cholangiocarcinoma-with-spinal-metastasis-single-center-survival-analysis
#8
Pawalee Dowsiriroj, Permsak Paholpak, Winai Sirichativapee, Taweechok Wisanuyotin, Pat Laupattarakasem, Kamolsak Sukhonthamarn, Weerachai Kosuwon, Polasak Jeeravipoolvarn
The aim of this study was to perform a survival analysis of Cholangiocarcinoma (CCA) with spinal metastases. 55 cases of CCA with spinal metastases were retrospectively reviewed. We recorded age, sex, Kanofsky performance score, Frankel scale, number and region of affected vertebrae, presence of appendicular bone metastases, treatment received, and survival time; then performed a survival analysis. Overall median survival was 4months (95%CI, 2.89-5.11). Frankel A had the poorest survival (2months-95%CI, 1.15-2...
January 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28107658/validation-of-a-personalized-curved-muscle-model-of-the-lumbar-spine-during-complex-dynamic-exertions
#9
Jaejin Hwang, Gregory G Knapik, Jonathan S Dufour, Thomas M Best, Safdar N Khan, Ehud Mendel, William S Marras
Previous curved muscle models have typically examined their robustness only under simple, single-plane static exertions. In addition, the empirical validation of curved muscle models through an entire lumbar spine has not been fully realized. The objective of this study was to empirically validate a personalized biologically-assisted curved muscle model during complex dynamic exertions. Twelve subjects performed a variety of complex lifting tasks as a function of load weight, load origin, and load height. Both a personalized curved muscle model as well as a straight-line muscle model were used to evaluate the model's fidelity and prediction of three-dimensional spine tissue loads under different lifting conditions...
January 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28107381/in-vivo-two-photon-imaging-of-astrocytes-in-gfap-gfp-transgenic-mice
#10
Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong
Astrocytes play important roles in normal brain function and neurological diseases. In vivo two-photon excitation laser scanning microscopy has the potential to reveal rapid, dynamic structural changes in cells in a variety of physiological and pathological conditions. The type of in vivo imaging method has been shown to affect the plasticity of dendritic spines of neurons, but the optimal in vivo imaging methods of astrocytes have not been established. We compared open-skull and thinned-skull imaging methods for two-photon laser microscopy of live astrocytes in neocortex of GFAP-GFP transgenic mice...
2017: PloS One
https://www.readbyqxmd.com/read/28107246/reliability-and-usefulness-of-intraoperative-3-dimensional-imaging-by-mobile-c-arm-with-flat-panel-detector
#11
Takahito Fujimori, Motoki Iwasaki, Yukitaka Nagamoto, Masafumi Kashii, Masaki Takao, Tsuyoshi Sugiura, Hideki Yoshikawa
STUDY DESIGN: Reliability and agreement study. OBJECTIVE: To assess the reliability of intraoperative 3-dimensional imaging with a mobile C-arm (3D C-arm) equipped with a flat-panel detector. SUMMARY OF BACKGROUND DATA: Pedicle screws are widely used in spinal surgery. Postoperative computed tomography (CT) is the most reliable method to detect screw misplacement. Recent advances in imaging devices have enabled surgeons to acquire 3D images of the spine during surgery...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107244/avoidance-of-wrong-level-thoracic-spine-surgery-using-sterile-spinal-needles-a-technical-report
#12
Kingsley R Chin, Jason Seale, Vanessa Cumming
STUDY DESIGN: A technical report. OBJECTIVE: The aim of the present study was to present an improvement on localization techniques employed for use in the thoracic spine using sterile spinal needles docked on the transverse process of each vertebra, which can be performed in both percutaneous and open spinal procedures. SUMMARY OF BACKGROUND DATA: Wrong-level surgery may have momentous clinical and emotional implications for a patient and surgeon...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107242/an-in-vitro-biomechanical-study-evaluating-cervical-extension-plates-for-stabilizing-degenerated-adjacent-levels
#13
Kamran Majid, Mark Moldavsky, Saif Khalil, Manasa Gudipally
STUDY DESIGN: To evaluate the biomechanical stability of 2 extender plates in a human cervical cadaveric model. OBJECTIVES: To evaluate 2 extender plates, placed adjacent to initially implanted plates and to compare their biomechanical stability with traditional techniques. SUMMARY OF BACKGROUND DATA: Traditionally, adjacent level degeneration is surgically treated by removing the previously implanted plate and extending the instrumentation to the new degenerated level...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107241/polytrauma-patients-with-associated-spine-fractures-an-assessment-of-surgical-intervention-on-patient-outcome
#14
Steven R Niedermeier, Safdar N Khan
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To examine perioperative characteristics among polytraumatized patients with operative, unstable spine fractures with and without concomitant operative long bone injuries. SUMMARY OF BACKGROUND DATA: Treatment of polytrauma patients has delicate and time-sensitive protocols to ensure successful recovery. The literature defines standards for vertebral injury and surgical intervention...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107239/management-of-pharyngeal-fistulas-after-anterior-cervical-spine-surgery-a-treatment-algorithm-for-severe-complications
#15
Christian Simon, Carl H Fürstenberg, Markus Eichler, Stefan Rohde, Cem Bulut, Bernd Wiedenhöfer
STUDY DESIGN: This study is a retrospective database query to identify all anterior spinal approaches. OBJECTIVES: The objectives were to assess all patients with pharyngocutaneous fistulas (PCFs) after anterior cervical spine surgery. SUMMARY OF BACKGROUND DATA: Patients with the diagnosis of PCFs were treated at the University of Heidelberg Spine Medical Center, Spinal Cord Injury Unit and Department of Otolaryngology (Germany), between 2005 and 2011...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107231/national-database-research-in-spine-surgery-limitations-in-the-current-literature
#16
Arjun S Sebastian
Many of the studies in the spine surgical literature using national databases have been directed at examining adverse events, readmission rates, cost, and risk factors for poorer outcomes. Although such studies allow for assessment of large cohorts taken from multiple institutions, they are limited by data collection methods, short-term follow-up, and minimal assessment of functional outcomes. Furthermore, few studies are directed at producing actionable practice changes to improve patient care. Recent work aimed at producing databases with more relevance to spine surgery represent exciting developments to the rapidly growing field of health outcomes research...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106525/open-and-endovascular-treatment-of-spinal-dural-arteriovenous-fistulas-a-10-year-experience
#17
Matthew J Koch, Christopher J Stapleton, Pankaj K Agarwalla, Collin Torok, John H Shin, Jean-Valery Coumans, Lawrence F Borges, Christopher S Ogilvy, James D Rabinov, Aman B Patel
OBJECTIVE Vascular malformations of the spine represent rare clinical entities with profound neurological implications. Previously reported studies on management strategies for spinal dural arteriovenous fistulas (sDAVFs) appeared before the advent of modern liquid embolic agents. Authors of the present study review their institutional experience with endovascularly and surgically treated sDAVFs. METHODS The authors performed a retrospective, observational, single-center case series on sDAVFs treated with endovascular embolization, microsurgical occlusion, or both between 2004 and 2013...
January 20, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28106515/solitary-fibrous-tumors-of-the-spine-a-pediatric-case-report-with-a-comprehensive-review-of-the-literature
#18
Gregory W Albert, Murat Gokden
Solitary fibrous tumors of the spine are rare lesions. Their description in the literature is limited to case reports and small case series. While generally benign lesions, they can recur and occasionally occur as malignancies. Here the authors present the case of a 10-year-old boy, the youngest patient and first preadolescent reported thus far, with this condition. In addition, they perform a comprehensive review of all previously published cases of spinal solitary fibrous tumors.
January 20, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28106355/comparative-study-of-fiberoptic-guided-versus-intubating-laryngeal-mask-airway-assisted-awake-orotracheal-intubation-in-patients-with-unstable-cervical-spine-a-randomized-controlled-trial
#19
Tanmay Jadhav, Kamath Sriganesh, Madhusudan K Reddy, Dhritiman Chakrabarti
BACKGROUND: A safe airway technique minimizes intubation-associated cervical-spine movement and consequent neurological injury in patients with unstable cervical spine (UCS). Awake fiberoptic-guided intubation (FGI) is preferred in patients with UCS. Alternatively, intubating laryngeal mask airway assisted intubation (ILMA-AI) can be performed both during elective and emergency, requires less expertise and is cost-effective. This study evaluated cervical-spine movement during FGI and ILMA-AI in patients with UCS...
January 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28104945/neonatal-and-infantile-spinal-sonography-a-useful-investigation-often-underutilized
#20
Nikhil Nair, M Sreenivas, Arun K Gupta, Devasenathipathy Kandasamy, Manisha Jana
Sonography is an ideal, effective, noninvasive tool for evaluation of the spinal cord in neonatal and early infantile age groups owing to lack of ossification of the posterior elements of spine. Understanding normal anatomical appearances is a prerequisite for the interpretation of various pathologies of the spinal canal and its contents. This review elucidates normal appearances of the spinal cord in this age group, in both axial and sagittal planes. Usefulness of Doppler sonography is briefly discussed, and special emphasis is placed on normal anatomical variants that may mimic spinal abnormalities...
October 2016: Indian Journal of Radiology & Imaging
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