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pemphigus vulgaris

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https://www.readbyqxmd.com/read/29770335/the-significance-of-scalp-involvement-in-pemphigus-a-literature-review
#1
REVIEW
Marta Sar-Pomian, Lidia Rudnicka, Malgorzata Olszewska
Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29755451/autoantibody-signaling-in-pemphigus-vulgaris-development-of-an-integrated-model
#2
REVIEW
Thomas Sajda, Animesh A Sinha
Pemphigus vulgaris (PV) is an autoimmune skin blistering disease effecting both cutaneous and mucosal epithelia. Blister formation in PV is known to result from the binding of autoantibodies (autoAbs) to keratinocyte antigens. The primary antigenic targets of pathogenic autoAbs are known to be desmoglein 3, and to a lesser extent, desmoglein 1, cadherin family proteins that partially comprise the desmosome, a protein structure responsible for maintaining cell adhesion, although additional autoAbs, whose role in blister formation is still unclear, are also known to be present in PV patients...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29751810/auto-immune-skin-diseases-in-animals-time-to-reclassify-and-review-after-40-years
#3
EDITORIAL
Thierry Olivry
It has been more than 40 years since the dual descriptions of canine pemphigus vulgaris. Over the ensuing four decades, the reports of-mostly canine-novel autoimmune skin diseases (AISDs) have progressed in successive waves separated by long periods of quiescence. This Editorial introduces a series of comprehensive review papers on the various canine and feline AISDs. This collection of articles aims at remediating the current veterinary literature deficiency on this topic by summarizing the key historical, clinical, histological, immunological and treatment characteristics of animal AISDs...
May 11, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29749496/increased-expression-of-microrna-338-3p-contributes-to-production-of-dsg3-antibody-in-pemphigus-vulgaris-patients
#4
Qingxiu Liu, Feiyi Cui, Menglei Wang, Hao Xiong, Xiaoming Peng, Liuping Liang, Li Li, Jing Zhang, Xuebiao Peng, Kang Zeng
Expression of microRNA-338-3p (miR-338-3p) was aberrantly elevated in pemphigus vulgaris (PV), although its role in PV is still unknown. The present study investigated the functional role and possible molecular mechanisms of miR-338-3p in PV. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to detect miR-338-3p expression in peripheral blood mononuclear cells (PBMCs) from patients with PV. Correlation with disease severity and anti-desmoglein 3 antibody (anti-Dsg3) titers were analyzed in patients with PV...
April 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29740210/emerging-treatment-options-for-the-management-of-pemphigus-vulgaris
#5
REVIEW
Khalaf Kridin
Pemphigus vulgaris (PV) is a life-threatening disease belonging to the pemphigus group of autoimmune intra-epidermal bullous diseases of the skin and mucosae. The therapeutic management of PV remains challenging and, in some cases, conventional therapy is not adequate to induce clinical remission. The cornerstone of PV treatment remains systemic corticosteroids. Although very effective, long-term corticosteroid administration is characterized by substantial adverse effects. Corticosteroid-sparing adjuvant therapies have been employed in the treatment of PV, aiming to reduce the necessary cumulative dose of corticosteroids...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29730882/beta-blockers-for-treatment-of-autoimmune-blistering-dermatosis
#6
Ayman Abdelmaksoud, Michelangelo Vestita
We read with interest a study by Miyamoto et al. published in the Journal of European Academy of Dermatology and Venereology. In their study, Miyamoto et al. found higher expression of vascular endothelial growth factor (VEGF) and endoglin in the tissue of erythrodermic pemphigus foliaceous (PF) compared to non-erythrodermic PF. According to the authors, both VEGF and endoglin may pose a prognostic predicting factors for adequate tissue repair in pemphigus patients; PF& pemphigus vulgaris (PV). The authors stated "therapy such as topical propranolol may enable adequate healing and disease remission"...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730879/beta-adrenoceptor-expression-in-pemphigus-foliaceus
#7
D Miyamoto, A B T Dias, V Aoki, M N Burnier
We appreciate the valuable comments from Drs. Abdelmaksoud and Vestita regarding our study about the in situ expression of vascular endothelial growth factor (VEGF) and endoglin in patients with pemphigus foliaceus (PF) and pemphigus vulgaris [1]. We proposed that the severity of PF is related not only to the level of circulating autoantibodies but also to the ability to restore tissue integrity following intraepidermal detachment. We have demonstrated that overexpression of VEGF is observed both in serum samples[2] and skin fragments obtained from patients with severe PF[3], and suggested the use of β-blockers to regulate it...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29729120/autoimmune-bullous-diseases-in-non-hiv-kaposi-s-sarcoma-a-retrospective-study-in-a-large-cohort-of-patients
#8
A Tourlaki, G Genovese, E Guanziroli, B M Scoppio, E Berti, L Brambilla
BACKGROUND: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpes virus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both KS and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29726598/contact-allergy-caused-by-methylisothiazolinone-in-a-mouthwash-as-the-likely-trigger-of-oral-pemphigus-vulgaris
#9
Rosella Gallo, Lodovica Gariazzo, Giulia Gasparini, Davide Basso, Antonino Torino, Emanuele Cozzani, Aurora Parodi
No abstract text is available yet for this article.
May 4, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29723379/oxidative-stress-in-patients-with-endemic-pemphigus-foliaceus-and-healthy-subjects-with-anti-desmoglein-1-antibodies
#10
Ericson Leonardo Gutierrez, Willy Ramos, Lucia Seminario-Vidal, Mercedes Tello, Gerardo Ronceros, Alex G Ortega-Loayza
BACKGROUND: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. OBJECTIVES: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. SUBJECTS AND METHODS: This is a cross-sectional study...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29719538/humoral-epitope-spreading-in-autoimmune-bullous-diseases
#11
REVIEW
Dario Didona, Giovanni Di Zenzo
Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29702999/immunological-markers-as-predictors-of-developing-steroid-induced-diabetes-mellitus-in-pemphigus-vulgaris-patients-an-observational-study
#12
Ana Sorina Dănescu, Ioana Bâldea, Daniel Corneliu Leucuţa, Iulia Lupan, Gabriel Samaşca, Cassian Sitaru, Roxana Chiorean, Adrian Baican
The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients with pemphigus vulgaris were studied. Patients with SID and pemphigus were compared with those that had only pemphigus. The variables recorded were: age at diagnosis, sex, body mass index, presence of diabetes mellitus (DM), cumulative cortisone dose, treatment duration, value of anti-desmoglein 1 and 3, and anti-glutamic acid decarboxylase autoantibodies...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29678378/desquamative-gingivitis-clinical-findings-and-diseases
#13
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive of a particular diagnosis, a thorough history, physical examination, and appropriate dermato- and immunopathologic assessment is necessary for narrowing this broad differential diagnosis...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29675021/anti-thyroid-peroxidase-reactivity-is-heightened-in-pemphigus-vulgaris-and-is-driven-by-human-leukocyte-antigen-status-and-the-absence-of-desmoglein-reactivity
#14
Kristina Seiffert-Sinha, Shahzaib Khan, Kristopher Attwood, John A Gerlach, Animesh A Sinha
Pemphigus vulgaris (PV) belongs to an autoimmune disease cluster that includes autoimmune thyroid disease (AITD), suggesting common mechanisms driving autoimmune susceptibility. Our group has shown that PV patients exhibit significant reactivity to AITD-related anti-thyroid peroxidase (anti-TPO), and anti-TPO antibodies affect signaling pathways in keratinocytes similar to anti-desmoglein (Dsg) 3 antibodies. To further assess the relevance of anti-TPO reactivity in PV, we analyzed anti-TPO levels in 280 PV and 167 healthy control serum samples across a comprehensive set of variable and static parameters of disease activity and etiopathogenesis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668335/electrocardiographic-changes-after-high-dose-corticosteroid-pulse-therapy-in-pemphigus-patients
#15
M Pishgahi, S Dadkhahfar, R M Robati, Z Kheradmand, M Shahidi-Dadras, O Zargari, D J Elpern
PURPOSE: The objective of the current study was to evaluate the effect of intravenous methylprednisolone pulse therapy on myocardial repolarization alterations, especially QT dispersion in anticipation of cardiovascular risks in patients with pemphigus vulgaris. METHODS: The current study is a prospective controlled study on the electrocardiographic changes after methylprednisolone pulse therapy in 50 patients with pemphigus vulgaris. RESULTS: A total of 50 patients (28 female and 22 male) were included in our study...
April 18, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29630151/paraneoplastic-pemphigus-without-antibodies-to-desmoglein-1-and-3
#16
Kelsey Flood, Christopher Stroud, Zelmira Lazarov, Nadarajah Vigneswara, Sylvia Hsu
Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Herein, we report a patient with paraneoplastic pemphigus whose routine testing led to a diagnosis of pemphigus vulgaris. However, further testing was pursued revealing an antibody profile consistent with paraneoplastic pemphigus...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29626572/th1-th17-cell-recognition-of-desmoglein-3-and-bullous-pemphigoid-antigen-180-in-lichen-planus
#17
Thomas Schmidt, Farzan Solimani, Robert Pollmann, Ronja Stein, Ansgar Schmidt, Inna Stulberg, Katja Kühn, Rüdiger Eming, Verena Eubel, Peter Kind, Nicole Arweiler, Cassian Sitaru, Michael Hertl
We identified Th1/Th17 cell responses against desmoglein 3 and bullous pemphigoid antigen 180 in lichen planus. In contrast, patients with pemphigus vulgaris and bullous pemphigoid showed significantly higher Th2 cell responses against these autoantigens.
April 4, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29616033/keratins-regulate-p38mapk-dependent-desmoglein-binding-properties-in-pemphigus
#18
Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y Radeva, Fanny Buechau, Thomas M Magin, Volker Spindler, Jens Waschke
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly caused by autoantibodies against desmoglein (Dsg) 1 and 3. Keratin alterations are a structural hallmark in pemphigus pathogenesis and correlate with loss of intercellular adhesion. However, the significance for autoantibody-induced loss of intercellular adhesion is largely unknown...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29609015/comparison-of-ethylenediaminetetraacetic-acid-treated-desmoglein-elisa-and-conventional-desmoglein-elisa-in-the-evaluation-of-pemphigus-vulgaris-in-remission
#19
Maryam Daneshpazhooh, Hamidreza Mahmoudi, Kamran Balighi, Amir Teimourpour, Zohreh Khodashenas, Maryam Ghiasi, Hasan Khosravi, Cheyda Chams-Davatchi
No abstract text is available yet for this article.
March 30, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29582787/association-between-human-leukocyte-antigen-drb1-and-human-leukocyte-antigen-dqb1-alleles-and-pemphigus-vulgaris-in-indian-patients-a-case-control-study
#20
Anuradha Priyadarshini, Renu George, Dolly Daniel, Santosh Varughese, Visalakshi Jayaseelan
BACKGROUND: HLA-DRB1*04, -DRB1*08, -DRB1*14, -DQB1*03 and -DQB1*05 are reported to have significant association with pemphigus vulgaris; however, this is partially dependent on ethnicity. This study was done to determine the HLA-DR and -DQ types prevalent in Indian patients with pemphigus vulgaris. METHODS: A prospective case-control study was done for a period of 9 months in Christian Medical College Vellore, India. HLA typing was done by PCR-SSOP method in 50 cases and 50 healthy controls...
March 27, 2018: Indian Journal of Dermatology, Venereology and Leprology
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