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pemphigus vulgaris

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https://www.readbyqxmd.com/read/29145342/evaluation-of-anti-desmoglein-1-and-anti-desmoglein-3-autoantibody-titers-in-pemphigus-patients-at-the-time-of-the-initial-diagnosis-and-after-clinical-remission
#1
Irene Russo, Francesco Paolo De Siena, Andrea Saponeri, Mauro Alaibac
It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and clinical activity of pemphigus.The aim of our study was to evaluate if clinical remission of pemphigus relates to the presence of anti-desmoglein autoantibodies.Thirty patients with pemphigus vulgaris and 7 patients with pemphigus foliaceous were included in the study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132070/sixteen-year-history-of-rituximab-therapy-for-1085-pemphigus-vulgaris-patients-a-systematic-review
#2
REVIEW
Soheil Tavakolpour, HamidReza Mahmoudi, Kamran Balighi, Robabeh Abedini, Maryam Daneshpazhooh
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Search in PubMed results in 114 relevant studies, which met the criteria...
November 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29110080/pemphigus-trigger-factors-special-focus-on-pemphigus-vulgaris-and-pemphigus-foliaceus
#3
REVIEW
Soheil Tavakolpour
Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed...
November 6, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29105150/feasibility-study-for-clinical-application-of-caspase-3-inhibitors-in-pemphigus-vulgaris
#4
W V J Hariton, A Galichet, T Vanden Berghe, A M Overmiller, M G Mahoney, W Declercq, E J Müller
No abstract text is available yet for this article.
November 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29096849/successful-and-well-tolerated-bi-weekly-immunoadsorption-regimen-in-pemphigus-vulgaris
#5
Jenny Dietze, Bernd Hohenstein, Sergey Tselmin, Ulrich Julius, Stefan R Bornstein, Stefan Beissert, Claudia Günther
BACKGROUND: Pemphigus vulgaris is a chronic autoimmune disease characterized by blisters and erosions forming in the mucous membranes and the skin. Many patients are severely impaired by pain, weight loss and increased risk of infections. The disease is mediated by specific autoantibodies directed against desmogleins that contribute to connect keratinocytes in the epidermis. Autoantibody deposition in the skin causes inflammation and intraepidermal akantholysis. The concentration of autoantibodies in serum correlates with disease activity...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095065/anterior-scleritis-associated-with-pemphigus-vulgaris
#6
Tal Zeeli, Efrat Bar-Ilan, Zohar Habot-Wilner, Eli Sprecher
We present a rare co-occurrence of anterior scleritis developing in a patient with recalcitrant pemphigus vulgaris. We discuss the clinical and therapeutic implications of these two conditions and offer concise recommendations.
November 2, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29071023/the-effect-of-low-level-laser-therapy-on-pemphigus-vulgaris-lesions-a-pilot-study
#7
Maryam Yousef, Parvin Mansouri, Masoud Partovikia, Mitra Esmaili, Shima Younespour, Ladan Hassani
Introduction: Pemphigus vulgaris is a chronic blistering skin disease. Management of recalcitrant pemphigus ulcers is a great problem. Low Level Laser Therapy (LLLT) is known to supply direct biostimulative light energy to body cells. This study evaluates the efficacy of low power laser in the healing of pemphigus lesions. Methods: Ten patients with pemphigus vulgaris were enrolled in the trial. The LED-LLLT system used was the Thor LED clusters (109, 69 or 19 diode) (England) with 660 nm wavelength in continuous wave (CW) and 30 mW energy...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29067729/antioxidant-status-of-serum-bilirubin-uric-acid-and-albumin-in-pemphigus-vulgaris
#8
W C Li, L J Mo, X Shi, Z Y Lin, Y Y Li, Z Yang, C L Wu, X H Li, Y Z Luo, L Q Qin, W N Mo
BACKGROUND: Oxidative stress and low antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Pemphigus vulgaris (PV) is an extremely severe autoimmune bullous dermatosis characterized by intraepithelial bullae on the skin and mucosa, and its antioxidant status is not fully understood. AIM: To assess correlations between PV and serum antioxidant levels of bilirubin, uric acid (UA) and albumin. METHODS: We enrolled 116 patients newly diagnosed with PV who were admitted to the First Affiliated Hospital of Guangxi Medical University (Guangxi, China), and 108 healthy controls (HCs)...
October 25, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29055412/desmoglein-3-reactive-b-cells-hiding-in-pemphigus-lesions
#9
Hayato Takahashi
Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Thus, it seems likely that autoreactive B cells reside and produce autoantibodies in these tissues. Yuan et al. analyzed lymphocytes in the lesional skin of patients with pemphigus vulgaris using several experimental techniques and concluded that desmoglein 3-reactive B cells were present...
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#10
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
October 18, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29035286/urocytological-evaluation-of-pemphigus-patients-on-long-term-cyclophosphamide-therapy-a-cross-sectional-study
#11
Sujay Khandpur, Saurabh Singh, Saumyaranjan Mallick, Vinod Kumar Sharma, Venkat Iyer, Amlesh Seth, Mahesh Kumawat
BACKGROUND: Cyclophosphamide therapy is associated with several urological complications including urinary bladder malignancy. Data on urologic complications of chronic cyclophosphamide therapy for dermatologic conditions is not available. OBJECTIVES: To study the urocytological profile of pemphigus patients on long-term cyclophosphamide therapy. MATERIALS AND METHODS: In a cross-sectional study, consecutive patients who had received cyclophosphamide therapy for pemphigus for more than 12 months were included...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29025105/pemphigus-vulgaris
#12
Tanay Chaubal, Ranjeet Bapat, Pooja Wadkar
No abstract text is available yet for this article.
August 16, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29016334/spatial-distribution-of-pemphigus-occurrence-over-five-decades-in-southeastern-brazil
#13
Beatriz Smidt Celere, Sebastian Vernal, Leonardo La Serra, Maria José Franco Brochado, Luiz Eduardo Moschini, Ana Maria Roselino, Susana Inés Segura-Muñoz
Well-defined locations of pemphigus cases support the hypothesis of environmental factors' involvement in its etiopathogenesis; however, these foci have never been described using specialized geographical tools. This is the first report to geo-reference pemphigus cases in a high-prevalence Brazilian region using geographic information systems. We aimed to report the spatio-temporal behavior of pemphigus foliaceus (PF) and vulgaris (PV) in southeastern Brazil, over the last five decades to describe geographical clusters, as well as to characterize the land use in the city with the highest number of cases...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994133/efficacy-of-perilesional-and-intralesional-triamcinolone-acetonide-injections-in-pemphigus-vulgaris-lesions-of-the-scalp-an-effective-therapeutic-option
#14
M Sar-Pomian, J Czuwara, T Grygorowicz, D Mirowska-Guzel, A Cudnoch-Jedrzejewska, L Rudnicka, M Olszewska
The scalp is a common location for pemphigus vulgaris (PV), and scalp lesions may be resistant to standard treatment. Perilesional/intralesional triamcinolone acetonide (TA) injections have been used successfully to treat oropharyngeal and ocular involvement in PV. Data on the efficacy of perilesional and intralesional triamcinolone acetonide injections in scalp lesions in PV are lacking. We report two patients with immunopathologically and histopathologically confirmed PV and residual scalp lesions resistant to standard treatment, who were treated with perilesional and intralesional injections of TA 10 mg/mL...
October 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28979862/comparison-of-direct-immunofluorescence-of-plucked-hair-and-skin-for-evaluation-of-immunological-remission-in-pemphigus
#15
Reena Rai, Manu V Harikumar
BACKGROUND: Pemphigus is a chronic autoimmune bullous disorder characterized by autoantibodies directed against desmoglein 3 and/or 1. Demonstration of intercellular deposition of IgG on the cell surface of keratinocytes by direct immunofluorescence (DIF) of the skin is the gold standard in the diagnosis of pemphigus. Recently, DIF of plucked hair demonstrating intercellular deposition of IgG in the outer root sheath (ORS) has shown to be useful. OBJECTIVE: To compare the DIF of plucked hair and skin for the evaluation of immunological remission in pemphigus vulgaris patients in clinical remission...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28932036/current-concepts-of-pemphigus-with-a-deep-insight-into-its-molecular-aspects
#16
REVIEW
Jayakiran Madala, Rithika Bashamalla, M Praveen Kumar
Pemphigus vulgaris is an autoimmune bullous disease involving both the skin and mucosal areas, which is characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not yet completely established, but novel intuitions into its pathogenesis have recently been published. An unanswered question in its pathophysiology is the mechanism of acantholysis or loss of keratinocyte cell adhesion. Acantholysis seems to result from a communal action of autoantibodies against numerous keratinocyte self-antigens, of which desmogleins 1 and 3, desmocollins and nondesmosome components, such as the mitochondrion, might take part in the disease initiation...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28928407/correlation-between-polymorphisms-of-the-nr3c1-gene-and-glucocorticoid-effectiveness-in-patients-with-pemphigus-vulgaris
#17
Si-Yue Fang, Chun-Lei Li, Xiao-Song Liu, Feng Chen, Hong Hua
Glucocorticoid (GC) resistance is the major obscule in the treatment of pemphigus vulgaris (PV) for both patients and clinicans with unclear mechanism. A hypotheis for this resistance is the mutations or polymorphisms present in the nuclear receptor subfamily 3, group C, member 1 (NR3C1) gene that encodes receptors for steroid hormones. This study aimed to investigate the association between NR3C1 gene polymorphisms and GC effectiveness in PV patients. 94 PV patients (64 GC-sensitive and 30 GC-resistant) and 100 healthy volunteers were enrolled in this case-control study...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912937/relieving-pain-in-oral-lesions-of-pemphigus-vulgaris-using-the-non-ablative-non-thermal-co2-laser-therapy-ntclt-preliminary-results-of-a-novel-approach
#18
Nasrin Zand, Parvin Mansouri, Mohsen Fateh, Leila Ataie-Fashtami, Samad Rezaee Khiabanloo, Farid Safar, Reza Chalangari, Katalin Martits, Afshan Shirkavand
Introduction: Pemphigus vulgaris (PV) is a chronic, serious autoimmune mucocutaneous bullous disease. Oral lesions in PV may be extremely painful. This pain may adversely affect the patients' oral intake and quality of life. This before-after clinical trial was designed to assess the pain relieving effects of single session of non-ablative, non-thermal CO2 laser therapy (NTCLT) in oral lesions of PV. Methods: Fifty painful oral lesions of fourteen patients with PV were illuminated by CO2 laser (power: 1 W, scanning the lesions with rapid circular motion of the handpiece) passing through a thick layer of transparent gel with high water content...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28892879/evaluation-of-anti-cyclic-citrullinated-peptide-autoantibodies-and-c-reactive-protein-in-common-autoimmune-skin-diseases-with-and-without-arthritis
#19
Bandana Kumari, Pawan Kumar, Radha Krishna Prasad Chaudhary
INTRODUCTION: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation. AIM: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. MATERIALS AND METHODS: Serum anti-CCP antibodies and CRP was measured in 50 patients of autoimmune skin disease of which 28 were of psoriasis, 12 of Systemic Lupus Erythematosus (SLE) and 10 of Pemphigus Vulgaris (PV)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892216/delayed-and-localized-pemphigus-vulgaris-after-breast-cancer-radiotherapy
#20
Hiu Kwan Carolyn Tang, Doreen Yin Hui Lee, Ian Thompson, John R Ingram, Natalie Stone, Girish K Patel
Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment. In contrast, occurrence of generalized pemphigus vulgaris in this setting may mean cancer recurrence...
November 2017: Breast Journal
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