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https://www.readbyqxmd.com/read/28944995/comparative-analysis-of-serum-proteome-in-congenital-scoliosis-patients-with-tbx6-haploinsufficiency-a-first-report-pointing-to-lipid-metabolism
#1
Qiankun Zhu, Nan Wu, Gang Liu, Yangzhong Zhou, Sen Liu, Jun Chen, Jiaqi Liu, Yuzhi Zuo, Zhenlei Liu, Weisheng Chen, Yixin Chen, Jia Chen, Mao Lin, Yanxue Zhao, Yang Yang, Shensgru Wang, Xu Yang, Yufen Ma, Jian Wang, Xiaoli Chen, Jianguo Zhang, Jianxiong Shen, Zhihong Wu, Guixing Qiu
Congenital scoliosis (CS) is a three-dimensional deformity of the spine affecting quality of life. We have demonstrated TBX6 haploinsufficiency is the most important contributor to CS. However, the pathophysiology at the protein level remains unclear. Therefore, this study was to explore the differential proteome in serum of CS patients with TBX6 haploinsufficiency. Sera from nine CS patients with TBX6 haploinsufficiency and nine age- and gender-matched healthy controls were collected and analysed by isobaric tagged relative and absolute quantification (iTRAQ) labelling coupled with mass spectrometry (MS)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944939/there-is-no-remarkable-differences-between-the-pedicle-screw-and-hybrid-construct-about-the-correction-of-lenke-type-i-curves
#2
Ulaş Serarslan, Emin Alici, Ömer Akçali, Can Koşay, Meriç Unal, Alper Gultekin
AIM: Lenke type-1, primary main thoracic curve pattern, is the most common spinal deformity pattern in adolescent idiopathic scoliosis (AIS). Posterior spinal fusion with all screw instrumentation or hybrid type instrumentation has been shown to achieve reliable deformity correction. The aim of this study is to compare deformity correction success of segmental pedicle screw and hybrid instrumentation for the treatment of Lenke type-1 AIS curves. MATERIAL AND METHODS: Surgically treated Lenke type-1 scoliosis patients were retrospectively evaluated and data of 26 patients that treated with hybrid instrumentation were included into first group...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944815/chemical-mediated-elasto-capillarity-of-elastic-sheets
#3
Jianlin Liu, Yulong Gong, Gaofeng Cao
Capillary forces can cause outstanding deformation of slender structures, and this behavior holds great potential in a plethora of areas. In this study, we propose a facile strategy to mediate the deformation of elastic structures via chemicals, which is named chemo-elasto-capillarity. The experiment shows that the added surfactant can significantly change the interfacial energy of the system, and then modulate the configuration of the adhered structures. The wetted length and deflection of each sheet can be predicted using the large and infinitesimal deformation theory of beams, and these theoretical values are in excellent agreement with the experimental results...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944805/stretchable-3d-lattice-conductors
#4
Tingyao Li, Yanhui Jiang, Kunhao Yu, Qiming Wang
3D architectures have been long harnessed to create lightweight yet strong cellular materials; however, the study regarding how 3D architectures facilitate the design of soft materials is at the incipient stage. Here, we demonstrate that 3D architectures can greatly facilitate the design of an intrinsically stretchable lattice conductor. We show that 3D architectures can be harnessed to enhance the overall stretchability of the soft conductors, reduce the effective density, enable resistive sensing of the large deformation of curved solids, and improve monitoring of a wastewater stream...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944446/response-of-the-freshwater-diatom-halamphora-veneta-k%C3%A3-tzing-levkov-to-copper-and-mercury-and-its-potential-for-bioassessment-of-heavy-metal-toxicity-in-aquatic-habitats
#5
Weijie Mu, Kun Jia, Yan Liu, Xuming Pan, Yawen Fan
This study investigates the effects of copper and mercury on growth rate, chlorophyll a content, superoxide dismutase (SOD) activity, SOD mRNA gene expression, and frustule morphology of the benthic freshwater diatom Halamphora veneta (Kützing) Levkov and the potential utility of each for toxicity assessment in aquatic habitats. Results showed the following: (1) Compared to mercury, exposure to copper resulted in greater growth inhibition of H. veneta even at low concentrations and after short durations of exposure; (2) high accumulation of chlorophyll a in H...
September 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28944394/buckling-driven-self-assembly-of-self-similar-inspired-micro-nanofibers-for-ultra-stretchable-electronics
#6
Jing Bian, Yajiang Ding, Yongqing Duan, Xiaodong Wan, YongAn Huang
Self-similar structures are capable of highly enhancing the deformability of stretchable electronics. We presented a self-assembly method based on the tunable buckling of serpentine fiber-based interconnects (FiberBIs), which are deposited using our presented helix electrohydrodynamic printing (HE-printing) technique, to fabricate self-similar structures with enhanced stretchability (up to 250%). It provides a low-cost, printing-based approach for the generation of large-scale self-similar FiberBIs. Distinct buckling behaviors and modes occur under specific conditions...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944346/falx-cerebri-segmentation-via-multi-atlas-boundary-fusion
#7
Jeffrey Glaister, Aaron Carass, Dzung L Pham, John A Butman, Jerry L Prince
The falx cerebri is a meningeal projection of dura in the brain, separating the cerebral hemispheres. It has stiffer mechanical properties than surrounding tissue and must be accurately segmented for building computational models of traumatic brain injury. In this work, we propose a method to segment the falx using T1-weighted magnetic resonance images (MRI) and susceptibility-weighted MRI (SWI). Multi-atlas whole brain segmentation is performed using the T1-weighted MRI and the gray matter cerebrum labels are extended into the longitudinal fissure using fast marching to find an initial estimate of the falx...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28944332/the-whitehead-operation-procedure-is-it-a-useful-technique
#8
Kenan Erzurumlu, Kağan Karabulut, Gökhan Selçuk Özbalcı, İsmail Alper Tarım, Gökhan Lap, Bülent Güngör
OBJECTIVE: Hemorrhoidal disease is a very common entity in the general population; however, the therapeutic approaches to hemorrhoids remain controversial. The choice of treatment method depends on the grade of the hemorrhoid as well as the experience of the surgeon. The Whitehead hemorrhoidectomy procedure is often applied for grade IV hemorrhoids. MATERIAL AND METHODS: We studied 49 patients who underwent surgery between December 1982 and January 2013. The indications for the Whitehead procedure in all patients were grade IV hemorrhoidal disease...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944086/development-of-spinal-deformities-in-the-tight-skin-mouse
#9
Bing Li, Jill Pg Urban, Jing Yu
Tight-skin (TSK) mice are commonly used as an animal model to study the pathogenesis of Marfan syndrome (MFS), but little is known of their skeletal phenotype and in particular of the development of the spinal deformities, common in MFS. Here we examined growth of the axial skeletons of TSK and wild-type(B6) mice during their period of rapid growth. The whole bodies of mice, 4-12 weeks of age, were scanned after sacrifice, by micro-computed tomography (microCT). We reconstructed three-dimensional models of the spine and ribs, and measured vertebral body heights and rib lengths using the Mac-based image-processing software "OsiriX"...
2017: Bone Research
https://www.readbyqxmd.com/read/28943994/preservation-of-the-sterile-matrix-hyponychium-and-fingertip-pad-in-fingertip-reconstruction-with-composite-fingertip-and-nail-bed-graft-and-volar-v-y-advancement-flap
#10
Joshua T Henderson, Steven A Schulz, Andrew M Swiergosz, Andrea R Hiller, J Stephen Gunn, Joshua H Choo, Morton L Kasdan, Bradon J Wilhelmi
Background: The goals of fingertip reconstruction are to achieve adequate soft-tissue coverage and a functional nail plate and to maintain sensation, proprioception, and cosmesis. Objective: We present a composite tissue graft and volar V-Y advancement flap for reconstruction of a traumatic amputation of a fingertip, which provided optimal preservation of the hyponychium and the volar pad for prevention of a hook nail. Historically, composite fingertip grafts have not been recommended for adults with large defects...
2017: Eplasty
https://www.readbyqxmd.com/read/28943702/efficient-multi-atlas-registration-using-an-intermediate-template-image
#11
Blake E Dewey, Aaron Carass, Ari M Blitz, Jerry L Prince
Multi-atlas label fusion is an accurate but time-consuming method of labeling the human brain. Using an intermediate image as a registration target can allow researchers to reduce time constraints by storing the deformations required of the atlas images. In this paper, we investigate the effect of registration through an intermediate template image on multi-atlas label fusion and propose a novel registration technique to counteract the negative effects of through-template registration. We show that overall computation time can be decreased dramatically with minimal impact on final label accuracy and time can be exchanged for improved results in a predictable manner...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28943082/nutritional-rickets-in-taiwanese-children-experiences-at-a-single-center
#12
Li-Hsin Chuang, Yi-Ching Tung, Shih-Yao Liu, Cheng-Ting Lee, Huey-Ling Chen, Wen-Yu Tsai
BACKGROUND/PURPOSE: The number of children with nutritional rickets in Taiwan has increased over the last decade. The aim of this study was to present our experiences in the management of patients with this condition. PATIENTS AND METHODS: From 2011 to 2016, 10 children (3 boys and 7 girls) with nutritional rickets were enrolled in this study. Their clinical and biochemical data were analyzed. RESULTS: The median age of the 10 patients was 21 months (range, 12-25 months)...
September 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28943071/classification-of-humeral-head-pathomorphology-in-primary-osteoarthritis-a-radiographic-and-in-vivo-photographic-analysis
#13
Peter Habermeyer, Petra Magosch, Christel Weiß, Nael Hawi, Sven Lichtenberg, Mark Tauber, Bastian Ipach
BACKGROUND: The purpose of this study was to characterize the pathologic changes of the osteoarthritic humeral head. METHODS: The study included 55 patients with primary osteoarthritis who underwent anatomic shoulder arthroplasty. Several radiologic parameters (radiography, magnetic resonance imaging) were assessed. Humeral head deformity in the transverse plane and humeral cartilage erosion in the coronal plane were chosen for photographic measurements from the resected humeral heads...
September 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28943068/hepatic-expression-of-metal-related-genes-and-gill-histology-in-sand-flathead-platycephalus-bassensis-from-a-metal-contaminated-estuary
#14
Dingkun Fu, Andrew Bridle, Melanie Leef, Catarina Norte Dos Santos, Barbara Nowak
Hepatic gene expression and gill histology were measured in sand flathead (Platycephalus bassensis) from a metal polluted estuary. The gene expression analyses were conducted on fish from two most polluted sites and a reference site. The metal-related genes were metal-regulatory transcription factor 1 (MTF1), transferrin (TF), ferriportin1 (FPN1), ferritin and metallothionein. The transcripts of MTF1, TF, and FPN1 were significantly higher in the liver of fish caught at polluted sites, suggesting these genes are potential biomarkers for environmental exposure to metal...
September 18, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28942742/atlanto-axial-rotatory-fixation-a-serious-potential-complication-of-paediatric-ent-surgery-that-requires-prompt-diagnosis-and-treatment
#15
G James, D N P Thompson
BACKGROUND: Atlanto-axial rotatory fixation is a persistent deformity of the C1-2 vertebral relationship caused by subluxation of the articular surfaces, and can occur after positioning for ENT procedures where the head is rotated - for example to access the ear or posterior triangle of the neck. If promptly recognised, it can usually be managed successfully with conservative methods, without long-lasting sequelae, but delayed or inappropriate management may lead to permanent neck deformity, neurological problems and pain...
September 25, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28942460/hip-arthroscopy-enables-classification-and-treatment-of-precollapse-subchondral-insufficiency-fracture-of-the-femoral-head-associated-intra-articular-pathology
#16
Soshi Uchida, Moriyuki Noguchi, Hajime Utsunomiya, Shiho Kanezaki, Toshiharu Mori, Dean K Matsuda, Akinori Sakai
PURPOSE: The purposes of this study were to investigate (1) the clinical, radiographic and arthroscopic presentation of patients with subchondral insufficiency fracture of the femoral head (SIFFH) and (2) the outcomes following arthroscopic treatment with internal fixation using hydroxyapatite poly-lactate acid (HA/PLLA) threaded pins and concomitant arthroscopic treatment of associated findings. METHODS: Nine patients (median age 49.0 years, range 43-65, five female and four male patients) with SIFFH who underwent arthroscopic treatment with labral repair, capsular closure and internal fixation of SIFFH using HA/PLLA pins were retrospectively reviewed...
September 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28942400/extreme-bony-pelvic-deformity-in-a-renal-transplant-patient
#17
Alexander Henry Moffat, Priyesh Chauhan, Surabhi Choudhary, Tarekegn Geberhiwot
A 35-year-old female renal transplant recipient was referred to the metabolic bone clinic because of a 15 cm loss of height. She was noted to have thoracic kyphosis and vertebral X-ray confirmed a wedge fracture of the eighth thoracic vertebra. She was managed accordingly but on subsequent follow-up mentioned in passing that her gynaecologist had been unable to obtain a cervical smear for routine screening. This led to further questioning, and the patient reported intermittent urinary stress incontinence, feelings of vaginal fullness and severe dyspareunia...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942368/dxa-derived-hip-shape-is-related-to-osteoarthritis-findings-from-in-the-mros-cohort
#18
Benjamin G Faber, Denis Baird, Celia L Gregson, Jenny S Gregory, Rebecca J Barr, Richard M Aspden, John Lynch, Michael C Nevitt, Nancy E Lane, Eric Orwoll, Jonathan H Tobias
OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort. METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study...
September 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28942364/toll-like-receptor-mediated-upregulation-of-cxcl16-in-psoriasis-orchestrates-neutrophil-activation
#19
Sabine Steffen, Susanne Abraham, Maik Herbig, Franziska Schmidt, Kristin Blau, Susann Meisterfeld, Stefan Beissert, Jochen Guck, Claudia Günther
Innate immune processes are central in the development of the chronic inflammatory skin disease psoriasis. Studying stimulation of keratinocytes, monocytes and dendritic cells by type I interferons or ligation of toll-like receptors TLR1/2, TLR2/6 or TLR7, but not TLR7/8, resulted in enhanced surface expression and secretion of the chemokine CXCL16. The corresponding receptor CXCR6 was expressed on neutrophils whose recruitment into skin is important especially in early psoriatic disease. Using the recently developed technique real-time deformability cytometry demonstrated that CXCL16 and IL-8 decreased the stiffness and enhanced deformation of neutrophils facilitating transmigration through vessel wall...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28942271/microstructure-changes-in-ultrafine-grained-nickel-processed-by-high-pressure-torsion-under-ultrasonic-treatment
#20
A A Samigullina, A A Mukhametgalina, S N Sergeyev, A P Zhilyaev, A A Nazarov, Yu R Zagidullina, N Yu Parkhimovich, V V Rubanik, Yu V Tsarenko
Commercially pure nickel was processed by high pressure torsion (HPT) and subjected to ultrasonic treatment (UST) with different amplitudes of compression-tension stresses in the zone of stress antinode of a standing wave. It was found that microstructure parameters such as the dislocation density, low- and high-angle grain boundary fractions, microhardness, and the stored excess energy as well, non-monotonically depend on the ultrasound amplitude. A structure relaxation leading to a reduction of internal stresses and stored energy and increase of the fraction of high-angle boundaries was observed at some intermediate amplitudes of the oscillating stress...
September 15, 2017: Ultrasonics
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