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https://www.readbyqxmd.com/read/28806752/the-escrt-iii-pathway-facilitates-cardiomyocyte-release-of-cbin1-containing-microparticles
#1
Bing Xu, Ying Fu, Yan Liu, Sosse Agvanian, Robert C Wirka, Rachel Baum, Kang Zhou, Robin M Shaw, TingTing Hong
Microparticles (MPs) are cell-cell communication vesicles derived from the cell surface plasma membrane, although they are not known to originate from cardiac ventricular muscle. In ventricular cardiomyocytes, the membrane deformation protein cardiac bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tubule (t-tubule) membrane microfolds, which facilitate ion channel trafficking and modulate local ionic concentrations. The microfold- generated microdomains continuously reorganize, adapting in response to stress to modulate the calcium signaling apparatus...
August 14, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28806748/temperature-effects-on-gene-expression-and-morphological-development-of-european-eel-anguilla-anguilla-larvae
#2
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Sune R Sørensen, Jonna Tomkiewicz, Ian A E Butts
Temperature is important for optimization of rearing conditions in aquaculture, especially during the critical early life history stages of fish. Here, we experimentally investigated the impact of temperature (16, 18, 20, 22 and 24°C) on thermally induced phenotypic variability, from larval hatch to first-feeding, and the linked expression of targeted genes [heat shock proteins (hsp), growth hormone (gh) and insulin-like growth factors (igf)] associated to larval performance of European eel, Anguilla anguilla...
2017: PloS One
https://www.readbyqxmd.com/read/28806647/mechanical-reinforcement-of-bioceramics-scaffolds-via-fracture-energy-dissipation-induced-by-sliding-action-of-mos2-nanoplatelets
#3
Cijun Shuai, Hang Sun, Chengde Gao, Pei Feng, Wang Guo, Youwen Yang, Mingchun Zhao, Sheng Yang, Fulai Yuan, Shuping Peng
The inherent brittleness of bioceramics restricts their applications in load bearing implant, although they possess good biocompatibility and bioactivity. In this study, molybdenum disulfide nanoplatelets (MSNPs) were used to reinforce bioceramics (Mg2SiO4/CaSiO3) scaffolds fabricated by selective laser sintering (SLS). The fracture mode of scaffolds was transformed from transgranular to mixed trans- and intergranular. It could be explained that MSNPs could slide easily due to their weak interlayer van der Waals interactions and provide elastic deformation due to their high elastic modulus...
July 20, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28806380/formation-of-the-philtral-column-using-a-dermal-graft-in-secondary-unilateral-cleft-lip
#4
Jeenam Kim, Jongok Park, Ki-Il Uhm, Donghyeok Shin, Hyungon Choi
INTRODUCTION: The philtral column has an important aesthetic significance and is especially important in patients with cleft lip. If the integrity of the philtrum cannot be preserved in patients of unilateral clefts, these patients will have profound abnormalities in their facial musculature. The purpose of this study was to analyze the effects of dermal grafting on the philtral column in patients with a unilateral alveolar cleft. METHODS: The authors retrospectively studied dermal grafts performed in Konkuk University Medical Center between January 2009 and January 2015...
August 10, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28806265/adult-acquired-flatfoot-deformity-etiology-diagnosis-and-management
#5
Mostafa M Abousayed, Maxwell C Alley, Rachel Shakked, Andrew J Rosenbaum
No abstract text is available yet for this article.
August 15, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28805871/asymmetric-motion-of-magnetically-actuated-artificial-cilia
#6
Srinivas Hanasoge, Matthew Ballard, Peter J Hesketh, Alexander Alexeev
Most microorganisms use hair-like cilia with asymmetric beating to perform vital bio-physical processes. In this paper, we demonstrate a novel fabrication method for creating magnetic artificial cilia capable of such a biologically inspired asymmetric beating pattern essential for inducing microfluidic transport at low Reynolds number. The cilia are fabricated using a lithographic process in conjunction with deposition of magnetic nickel-iron permalloy to create flexible filaments that can be manipulated by varying an external magnetic field...
August 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28805776/-diagnostic-and-curative-bronchoscopy-for-purulent-destructive-pulmonary-diseases
#7
T P Pinchuk, O O Yasnogorodsky, Yu V Guryanova, M V Taldykin, A S Kachikin, Yu A Catane
AIM: To assess an efficacy of diagnostic and curative bronchoscopy in patients with purulent-destructive pulmonary diseases. MATERIAL AND METHODS: Diagnosis and treatment of 34 patients with purulent-destructive pulmonary diseases including small-focal destruction (14) and lung abscesses (19) were analyzed. 33 patients underwent diagnostic fibrobronchoscopy (FBS) with brush and transbronchial biopsy. Curative endoscopy included bronchial tree sanation, peribronchial administration of antibiotics (5) and transbronchial drainage of abscess (14)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28805381/compressibility-anisotropy-and-electronic-properties-of-oxyanionic-hydrates
#8
Dmitry Vasilievich Korabel'nikov, Yuriy N Zhuravlev
The structural and electronic properties of oxyanionic crystalline hydrates, LiNO3•3H2O, LiClO4•3H2O and NaClO4•H2O, have been studied using density functional theory including van der Waals interactions. It is established that the linear compressibility of lithium perchlorate trihydrate is anisotropic (a < c) and positive, while lithium nitrate trihydrate and sodium perchlorate monohydrate demonstrate negative linear compressibility along the b and c- axes, respectively. Deformation of Ow-H•••O hydrogen bonding motifs is correlated with the negative linear compressibility...
August 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28805144/a-qm-protein-ligand-investigation-of-anti-psychotic-drugs-with-the-dopamine-d2-receptor-d2r
#9
Ramin Ekhteiari Salmas, Yusuf Serhat Is, Serdar Durdagi, Matthias Stein, Mine Yurtsever
The dopamine D2 Receptor (D2R) is a member of the G-Protein Coupled Receptor (GPCR) family and plays a critical role in neurotransmission activities in the human brain. Dysfunction in dopamine receptor signaling may lead to mental health illnesses such as schizophrenia and Parkinson's disease. D2R is the target protein of the commonly used anti-psychotic drugs such as risperidone, clozapine, aripiprazole, olanzapine, ziprasidone and quetiapine. Due to their significant side effects and nonselective profiles, the discovery of novel drugs has become a challenge for researchers working in this field...
August 14, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28805064/double-crystalline-multiblock-copolymers-with-controlling-microstructure-for-high-shape-memory-fixity-and-recovery
#10
Miaoming Huang, Liuchun Zheng, Lili Wang, Xia Dong, Xia Gao, Chuncheng Li, Dujin Wang
The shape memory performance of double crystalline poly(butylene succinate)-co-poly(ε-caprolactone) (PBS-co-PCL) multiblock copolymers with controlling microstructure was studied, and the corresponding microstructure origin was further quantitatively analyzed by wide and small angle X-ray scattering (WAXS and SAXS) experiments. It was found that the multiblock copolymer with higher PCL content, proper deformation strain and inhibited crystallization of PBS (lower crystallinity and smaller crystal size, which could be realized by quenching from the melt) would exhibit better shape memory fixity and recovery performance...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28805041/direct-microrolling-processing-on-a-silicon-wafer
#11
Kanna Aoki, Keita Ishiguro, Masaki Denokami, Yuya Tanahashi, Kentaro Furusawa, Norihiko Sekine, Tadafumi Adschiri, Minoru Fujii
Although, varieties of micro- to nanoscale fabrication technologies have been invented and refined for silicon (Si) processing because Si is the basic material of integrated circuits, the layouts are based on layer-by-layer approaches, making it difficult to realize three-dimensional (3D) structures with complicated shapes normal to the planar surface (along the out-of-plane direction) of the wafers used. Here, a novel and direct Si-processing technology that enables to bend thin layers of Si surfaces into various 3D curved structures at the micrometer scale is introduced...
August 14, 2017: Small
https://www.readbyqxmd.com/read/28805010/characterization-of-hydrogels-made-of-a-novel-spider-silk-protein-emasp1s-and-evaluation-for-3d-printing
#12
Christopher Thamm, Elise DeSimone, Thomas Scheibel
Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into scaffolds. Further, blending with a recombinantly produced MaSp2 derivative eADF4(C16) alters the mechanical properties of the resulting hydrogels. Different spider silk hydrogels also show a distinct recovery after a high shear stress deformation, exhibiting the tunability of their features for selected applications...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28804896/load-dependence-of-myocardial-deformation-variables-a-clinical-strain-echocardiographic-study
#13
M Fredholm, K Jörgensen, E Houltz, S-E Ricksten
BACKGROUND: The effects of left ventricular (LV) loading on myocardial deformation variables are not well-studied in the clinical setting. In the present study, we evaluated the effects of isolated changes in preload, afterload and heart rate on LV longitudinal strain, systolic (SR-S) and early diastolic strain rate (SR-E) in post-cardiac surgery patients. METHODS: Twenty-one patients were studied early after cardiac surgery. Longitudinal myocardial strain and SR were analysed off-line using 2-D speckle echocardiography...
August 13, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28804716/open-wedge-high-tibial-osteotomy-with-distal-tubercle-osteotomy-lessens-change-in-patellar-position
#14
Hoon Park, Hyun Woo Kim, Jin Hwa Kam, Dong Hoon Lee
The purpose of this study was to investigate the change in patellar position after open wedge high tibial osteotomy (OWHTO) with distal tubercle osteotomy (DTO), comparing outcomes of conventional OWHTO in young adults with proximal tibia varus deformity but no arthritic manifestations. Thirty-three patients (mean age, 31.8 years) subjected to OWHTO/DTO were matched with 30 patients (mean age, 33.5 years) undergoing conventional OWHTO. Patellar position, as measured in pre- and postoperative standing lateral radiographs, was compared...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28804520/fast-simulation-of-lipid-vesicle-deformation-using-spherical-harmonic-approximation
#15
Michael Mikucki, Yongcheng Zhou
Lipid vesicles appear ubiquitously in biological systems. Understanding how the mechanical and intermolecular interactions deform vesicle membranes is a fundamental question in biophysics. In this article we develop a fast algorithm to compute the surface configurations of lipid vesicles by introducing surface harmonic functions to approximate the membrane surface. This parameterization allows an analytical computation of the membrane curvature energy and its gradient for the efficient minimization of the curvature energy using a nonlinear conjugate gradient method...
January 2017: Communications in Computational Physics
https://www.readbyqxmd.com/read/28803705/collagen-fibril-organization-in-chicken-and-porcine-skeletal-muscle-perimysium-under-applied-tension-and-compression
#16
Melika Mohammadkhah, Paula Murphy, Ciaran K Simms
The tension/compression asymmetry observed in the stress-stretch response of skeletal muscle is not well understood. The collagen network in the extracellular matrix (ECM) almost certainly plays a major role, but the details are unknown. This paper reports qualitatively and quantitatively on skeletal muscle ECM reorganization during applied deformation using confocal imaging of collagen through use of a fluorescently-tagged specific collagen binding protein (CNA35-EGFP) of porcine and chicken muscle samples under tensile and compressive deformation in both the fibre and cross-fibre directions...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28803684/role-of-two-dimensional-speckle-tracking-echocardiography-strain-in-the-assessment-of%C3%A2-right-ventricular-systolic-function-and-comparison-with-conventional-parameters
#17
REVIEW
Luca Longobardo, Valentin Suma, Renuka Jain, Scipione Carerj, Concetta Zito, Dianne L Zwicke, Bijoy K Khandheria
Despite the already well-known role the right side of the heart plays in many diseases, right ventricular (RV) function has only recently been carefully considered. Echocardiography is the first-line diagnostic technique for the assessment of the right ventricle and right atrium, whereas cardiac magnetic resonance is considered the gold standard but is limited by cost and availability. According to the current guidelines, systolic RV function should be assessed by several conventional measurements, but the efficacy of these parameters as diagnostic and prognostic tools has been questioned by many authors...
August 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28803627/bubble-bubble-interactions-in-a-2d-foam-close-to-the-wet-limit
#18
REVIEW
D Weaire, R Höhler, S Hutzler
Following the general approach of Morse and Witten for the deformation of a bubble in contact with neighbouring bubbles, we develop a model for contacting bubbles in two dimensions which can be solved analytically. The force-displacement relations are derived by elementary methods; unlike the case of 3d, no logarithmic factors arise in two dimensions. We also discuss the case of a uniform compression of a symmetric foam structure; the (osmotic) compressibility depends on the number of contacts, as was shown in earlier work by Lacasse et al...
July 13, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28803243/lithium-sensitivity-of-store-operated-ca2-entry-and-survival-of-fibroblasts-isolated-from-chorea-acanthocytosis-patients
#19
Lisann Pelzl, Bhaeldin Elsir, Itishri Sahu, Rosi Bissinger, Yogesh Singh, Basma Sukkar, Sabina Honisch, Ludger Schoels, Mohamed Jemaà, Elisabeth Lang, Alexander Storch, Andreas Hermann, Christos Stournaras, Florian Lang
BACKGROUND: The widely expressed protein chorein fosters activation of the phosphoinositide 3 kinase (PI3K) pathway thus supporting cell survival. Loss of function mutations of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein 13A) causes chorea-acanthocytosis (ChAc), a neurodegenerative disorder paralleled by deformations of erythrocytes. In mice, genetic knockout of chorein leads to enhanced neuronal apoptosis. PI3K dependent signalling upregulates Orai1, a pore forming channel protein accomplishing store operated Ca2+ entry (SOCE)...
August 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28803114/the-inferomedial-femoral-neck-is-compromised-by-age-but-not-disease-fracture-toughness-and-the-multifactorial-mechanisms-comprising-reference-point-microindentation
#20
T Jenkins, O L Katsamenis, O G Andriotis, L V Coutts, B Carter, D G Dunlop, R O C Oreffo, C Cooper, N C Harvey, P J Thurner, The OStEO Group
The influence of ageing on the fracture mechanics of cortical bone tissue is well documented, though little is known about if and how related material properties are further affected in two of the most prominent musculoskeletal diseases, osteoporosis and osteoarthritis (OA). The femoral neck, in close proximity to the most pertinent osteoporotic fracture site and near the hip joint affected by osteoarthritis, is a site of particular interest for investigation. We have recently shown that Reference Point micro-Indentation (RPI) detects differences between cortical bone from the femoral neck of healthy, osteoporotic fractured and osteoarthritic hip replacement patients...
June 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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