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https://www.readbyqxmd.com/read/27932207/the-current-state-of-therapeutic-and-t-cell-based-vaccines-against-human-papillomaviruses
#1
REVIEW
Andrew Yang, Emily Farmer, John Lin, T-C Wu, Chien-Fu Hung
Human papillomavirus (HPV) is known to be a necessary factor for many gynecologic malignancies and is also associated with a subset of head and neck malignancies. This knowledge has created the opportunity to control these HPV-associated cancers through vaccination. However, despite the availability of prophylactic HPV vaccines, HPV infections remain extremely common worldwide. In addition, while prophylactic HPV vaccines have been effective in preventing infection, they are ineffective at clearing pre-existing HPV infections...
December 5, 2016: Virus Research
https://www.readbyqxmd.com/read/27761785/physical-and-psychological-health-in-rare-cancer-survivors
#2
Nora K Horick, Adoma Manful, Jan Lowery, Susan Domchek, Patricia Moorman, Constance Griffin, Kala Visvanathan, Claudine Isaacs, Anita Y Kinney, Dianne M Finkelstein
PURPOSE: Registries provide a unique tool for tracking quality of life in rare cancer survivors, whose survivorship experience is less known than for common cancers. This paper reports on these outcomes in 321 patients enrolled in the Rare Cancer Genetics Registry diagnosed with rare gastrointestinal, genitourinary, gynecologic, sarcoma, head/neck, or hematologic cancers. METHODS: Four outcomes were assessed, reflecting registrants' self-reported physical and mental health, psychological distress, and loneliness...
October 19, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27587055/design-and-testing-of-a-phantom-and-instrumented-gynecological-applicator-based-on-gan-dosimeter-for-use-in-high-dose-rate-brachytherapy-quality-assurance
#3
P Guiral, J Ribouton, P Jalade, R Wang, J-M Galvan, G-N Lu, P Pittet, A Rivoire, L Gindraux
PURPOSE: High dose rate brachytherapy (HDR-BT) is widely used to treat gynecologic, anal, prostate, head, neck, and breast cancers. These treatments are typically administered in large dose per fraction (>5 Gy) and with high-gradient-dose-distributions, with serious consequences in case of a treatment delivery error (e.g., on dwell position and dwell time). Thus, quality assurance (QA) or quality control (QC) should be systematically and independently implemented. This paper describes the design and testing of a phantom and an instrumented gynecological applicator for pretreatment QA and in vivo QC, respectively...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27364874/the-nuances-of-brachytherapy-taught-by-teachers-from-beyond-questionnaire-based-assessment-of-the-first-cadaveric-hands-on-brachytherapy-workshop-in-india
#4
Ram Charith Alva, Kirthi Koushik Agrahara Sreenivasa, Janaki Manur Gururajachar, Arul Ponni Thiru Raju, Mohan S Kumar, Ramesh S Bilimagga, Gurunath Kilara, Harish Krishnamachar, Satish Chandramouli
PURPOSE: A questionnaire-based assessment of a cohort of young radiation oncologists attending the first human cadaveric hands-on brachytherapy workshop in India. METHODS AND MATERIALS: The cadaveric workshop for hands-on training in head/neck and gynecologic cancers was a novel process conducted at M.S. Ramaiah Medical College and Hospital, for which 30 attendees from all regions of India took part with an opportunity to interact with experienced resource persons, individually perform the procedure, and indulge in all aspects of brachytherapy process...
September 2016: Brachytherapy
https://www.readbyqxmd.com/read/27330792/analysis-of-baseline-hepatitis-b-virus-dna-levels-in-chronic-hepatitis-b-patients-with-non-hematological-malignancies-prior-to-the-initiation-of-cancer-chemotherapy
#5
Shih-Hao Young, Tien-Hsin Wei, Chung-Chi Lin, Chi-Jen Chu, Fa-Yauh Lee, May-Ing Yu, Rei-Hwa Lu, Chiao-Yu Chang, Pei-Ling Yang, Mei-Hui Wang, Han-Chieh Lin
Reactivation of hepatitis B virus (HBV) infection is common (~20-50%) during cancer chemotherapy. Baseline HBV replication status is an important risk factor for HBV reactivation. To date, data on the baseline HBV DNA level for chronic hepatitis B (CHB) patients prior to chemotherapy, particularly for non-hematological malignancies, are limited. A total of 105 consecutive CHB patients with solid tumors who received prophylactic antiviral therapy prior to chemotherapy from November, 2011 to December, 2014, were enrolled in this study...
July 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27298767/relationship-and-interactions-of-curcumin-with-radiation-therapy
#6
REVIEW
Vivek Verma
Curcumin is widely reported to have remarkable medicinal - and antineoplastic - properties. This review details curcumin's relationship with radiotherapy (RT), principally as a radiosensitizer for various malignancies and a radioprotector for normal tissues. First, examples of radiosensitization are provided for various cancers: Pediatric, lymphoma, sarcoma, prostate, gynecologic, pancreas, liver, colorectal, breast, lung, head/neck, and glioma. It is not the purpose of this article to comprehensively review all radiosensitization data; however, high-quality studies are discussed in relationship to currently-controversial RT questions for many cancers, and thus the importance of developing a natural radiosensitizer...
June 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27229869/chronic-condition-clusters-and-functional-impairment-in-older-cancer-survivors-a-population-based-study
#7
Kelly M Kenzik, Erin E Kent, Michelle Y Martin, Smita Bhatia, Maria Pisu
PURPOSE: The purpose of the study is to identify chronic condition clusters at pre- and post-cancer diagnosis, evaluate predictors of developing clusters post-cancer, and examine the impact on functional impairment among older cancer survivors. METHODS: We identified 5991 survivors age 65 and older of prostate, breast, colorectal, lung, bladder, kidney, head and neck, and gynecologic cancer and non-Hodgkin lymphoma from the Surveillance, Epidemiology and End Results-Medicare Health Outcomes Survey resource...
December 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27090851/danish-translation-and-linguistic-validation-of-the-u-s-national-cancer-institute-s-patient-reported-outcomes-version-of-the-common-terminology-criteria-for-adverse-events-pro-ctcae
#8
Christina Bæksted, Aase Nissen, Helle Pappot, Pernille Envold Bidstrup, Sandra A Mitchell, Ethan Basch, Susanne Oksbjerg Dalton, Christoffer Johansen
CONTEXT: The Common Terminology Criteria for Adverse Events (CTCAE) is the basis for standardized clinician-based grading and reporting of adverse events in cancer clinical trials. The U.S. National Cancer Institute has developed the Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE) to incorporate patient self-reporting of symptomatic adverse events. OBJECTIVES: The aim of the study was to translate and linguistically validate a Danish language version of PRO-CTCAE...
August 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/26993288/streptococcus-agalactiae-infection-in-cancer-patients-a-five-year-study
#9
B A S Pimentel, C A S Martins, J C Mendonça, P S D Miranda, G F Sanches, A L Mattos-Guaraldi, P E Nagao
Although the highest burden of Streptococcus agalactiae infections has been reported in industrialized countries, studies on the characterization and epidemiology are still limited in developing countries and implementation of control strategies remains undefined. The aim of this retrospective study was to assess the epidemiological, clinical, and microbiological aspects of S. agalactiae infections in cancer patients treated at a Reference Brazilian National Cancer Institute - INCA, Rio de Janeiro, Brazil. We reviewed the clinical and laboratory records of all cancer patients identified as having invasive S...
June 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26991917/effect-of-folic-acid-supplementation-on-cancer-risk-among-adults-with-hypertension-in-china-a-randomized-clinical-trial
#10
Xianhui Qin, Lin Shen, Rong Zhang, Youbao Li, Xiaobin Wang, Binyan Wang, Xiaodong Jiang, Hua Jiang, Yu Lei, Fan Fan Hou, Jin Gu, Yong Huo
: The relationship of folic acid supplementation with the risk of cancer remains inconclusive. We aimed to evaluate the effects of folic acid supplementation on cancer incidence among adults with hypertension without history of stroke or myocardial infarction(MI) in the China Stroke Primary Prevention Trial(CSPPT). A total of 20,702 hypertensive adults without history of stroke or MI, stratified by MTHFR C677T genotypes(CC, CT, and TT), were randomly assigned to receive double-blind daily treatment with a single pill containing 10mg enalapril and 0...
March 17, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26979757/association-between-polymorphism-rs678653-in-human-cyclin-d1-gene-ccnd1-and-susceptibility-to-cancer-a-meta-analysis
#11
Xichao Dai, Xizhi Zhang, Buhai Wang, Chaomin Wang, Jingting Jiang, Changping Wu
BACKGROUND: To assess the association between polymorphism rs678653 in human Cyclin D1 gene (CCND1) and the risk of cancer. MATERIAL/METHODS: Multiple biomedical databases were systematically searched. Pooled odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated in the appropriate model. RESULTS: In total, 17 case-control studies from 14 articles were included. When combing all available data, no significant association of rs678653 with cancer risk was observed under different genetic models...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26925690/cancers-among-south-east-asian-nationals-in-brunei-darussalam
#12
Vui Heng Chong, Pemasari Upali Telisinghe, Edwin Lim, Jackson Tan, Chee Fui Chong
BACKGROUND: Worldwide, the incidence of cancers is increasing and is becoming a major public health issue, including those in the Asia Pacific region. South-East Asia is a region with diverse populations with different disease spectra. This study looked at the spectrum of cancers among South-East Asians working in Brunei Darussalam. MATERIALS AND METHODS: The cancer registry from 1994 to 2012 maintained by the State Laboratory was retrospectively reviewed. Crude incidence rates were calculated based on the population census of 2010...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26907449/analysis-of-after-hours-patient-telephone-calls-in-two-academic-radiation-oncology-departments-an-opportunity-for-improvement-in-patient-safety-and-quality-of-care
#13
Laura E G Warren, Miranda B Kim, Neil E Martin, Helen A Shih
PURPOSE: Patient care within radiation oncology extends beyond the clinic or treatment hours. The on-call radiation oncologist is often not a patient's primary radiation oncologist, introducing the possibility of communication breakdowns and medical errors. This study analyzed after-hours telephone calls to identify opportunities for improved patient safety and quality of care. METHODS AND MATERIALS: Patient calls received outside of business hours between July 1, 2013, and June 30, 2014, at two academic radiation oncology departments were retrospectively reviewed...
April 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/26430537/validation-of-whole-slide-imaging-for-frozen-section-diagnosis-in-surgical-pathology
#14
Thomas W Bauer, Renee J Slaw, Jesse K McKenney, Deepa T Patil
BACKGROUND: Whole slide imaging (WSI) using high-resolution scanners is gaining acceptance as a platform for consultation as well as for frozen section (FS) evaluation in surgical pathology. We report results of an intra-observer concordance study comparing evaluation of WSI of scanned FS microscope slides with the original interpretation of the same microscope slides after an average lag time of approximately 1-year. METHODS: A total of 70 FS cases (148 microscope slides) originally interpreted by 2 pathologists were scanned at ×20 using Aperio CS2 scanner (Leica Biosystems, San Diego, CA, USA)...
2015: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/26371432/identification-of-human-papillomavirus-infection-in-cancer-tissue-by-targeted-next-generation-sequencing
#15
Nathan D Montgomery, Joel S Parker, David A Eberhard, Nirali M Patel, Karen E Weck, Norman E Sharpless, Zhiyuan Hu, David Neil Hayes, Margaret L Gulley
Human papillomaviruses (HPV) are oncogenic DNA viruses implicated in squamous cell carcinomas of several anatomic sites, as well as endocervical adenocarcinomas. Identification of HPV is an actionable finding in some carcinomas, potentially influencing tumor classification, prognosis, and management. We incorporated capture probes for oncogenic HPV strains 16 and 18 into a broader next-generation sequencing (NGS) panel designed to identify actionable mutations in solid malignancies. A total of 21 head and neck, genitourinary, and gynecologic squamous cell carcinomas and endocervical adenocarcinomas were sequenced as part of the UNCSeq project...
August 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26305992/an-advanced-practice-nurse-coordinated-multidisciplinary-intervention-for-patients-with-late-stage-cancer-a-cluster-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Ruth McCorkle, Sangchoon Jeon, Elizabeth Ercolano, Mark Lazenby, Amanda Reid, Marianne Davies, Diane Viveiros, Scott Gettinger
BACKGROUND: Early palliative care provided through a palliative care consultative service is effective in enhancing patient outcomes. However, it is unknown whether the integration of palliative care as part of routine comprehensive cancer care improves patients' self-reported clinical outcomes. OBJECTIVE: The objective of this study was to evaluate the effects of a multidisciplinary coordinated intervention by advanced practice nurses at the clinic level on outcomes with patients newly diagnosed with late-stage cancer...
November 2015: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/26274393/risk-of-severe-acute-exacerbation-of-chronic-hbv-infection-cancer-patients-who-underwent-chemotherapy-and-did-not-receive-anti-viral-prophylaxis
#17
Chih-An Shih, Wen-Chi Chen, Hsien-Chung Yu, Jin-Shiung Cheng, Kwok-Hung Lai, Jui-Ting Hsu, Hui-Chun Chen, Ping-I Hsu
BACKGROUND: Reactivation of HBV replication with an increase in serum HBV DNA and alanine aminotransferase (ALT) activity has been reported in 20-50% of hepatitis B carriers undergoing cytotoxic chemotherapy for cancer treatment. Manifestation of HBV reactivation ranges from asymptomatic self-limiting hepatitis to severe progressive hepatic failure and fatal consequences. AIM: To investigate the risk of severe acute exacerbation of chronic HBV infection in HBsAg-positive cancer patients with solid tumors or hematological malignancies who underwent chemotherapy without antiviral prophylaxis...
2015: PloS One
https://www.readbyqxmd.com/read/26049692/trends-in-adjuvant-and-neoadjuvant-radiotherapy-for-cancer-treatment-from-1973-to-2011
#18
Daniel Le Bui, James Byunghoon Yu
PURPOSE: Cancer care is becoming increasingly complicated, in particular with the integration of radiation and surgery. Institutions may need to increase coordination between multidisciplinary clinical teams to optimize patient care. This study examines historical trends in adjuvant and neoadjuvant radiation therapy (ANRT) before or after cancer-directed surgery to identify disease sites that may benefit from coordinated care. METHODS: The Surveillance, Epidemiology, and End Results database was queried to identify patients with bladder cancer; breast cancer; cervical cancer; colorectal cancer; kidney cancer; cancer of the lung, bronchus, and pleura; lymphoma; melanoma; cancer of the oral cavity and pharynx; ovarian cancer; pancreatic cancer; prostate cancer; thyroid cancer; and uterine cancer from 1973 to 2011...
May 2015: Cancer Journal
https://www.readbyqxmd.com/read/26030731/squamousness-next-generation-sequencing-reveals-shared-molecular-features-across-squamous-tumor-types
#19
Maria Schwaederle, Sheryl K Elkin, Brett N Tomson, Jennifer Levin Carter, Razelle Kurzrock
In order to gain a better understanding of the underlying biology of squamous cell carcinoma (SCC), we tested the hypothesis that SCC originating from different organs may possess common molecular alterations. SCC samples (N = 361) were examined using clinical-grade targeted next-generation sequencing (NGS). The most frequent SCC tumor types were head and neck, lung, cutaneous, gastrointestinal and gynecologic cancers. The most common gene alterations were TP53 (64.5% of patients), PIK3CA (28.5%), CDKN2A (24...
2015: Cell Cycle
https://www.readbyqxmd.com/read/25937998/distinct-genetic-alterations-in-small-cell-carcinoma-from-different-anatomic-sites
#20
REVIEW
Xiaoyong Zheng, Delong Liu, John T Fallon, Minghao Zhong
Small cell carcinoma (SmCC) is a distinct clinicopathological entity first described in the lung. It represents approximately 15% of all bronchogenic carcinoma. Extrapulmonary small cell carcinoma (EPSmCC) morphologically indistinguishable from small cell lung cancer (SCLC) was first reported in 1930. Since its first description, EPSmCC has been reported in virtually all anatomical sites, including: gynecologic organs (ovary and cervix); genitourinary organs (urinary bladder and prostate); the gastrointestinal tract (esophagus); skin (Merkel cell carcinoma) and head and neck region...
2015: Experimental Hematology & Oncology
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