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https://www.readbyqxmd.com/read/29679165/future-brain-and-spinal-cord-volumetric-imaging-in-the-clinic-for-monitoring-treatment-response-in-ms
#1
REVIEW
Tim Sinnecker, Cristina Granziera, Jens Wuerfel, Regina Schlaeger
PURPOSE OF REVIEW: Volumetric analysis of brain imaging has emerged as a standard approach used in clinical research, e.g., in the field of multiple sclerosis (MS), but its application in individual disease course monitoring is still hampered by biological and technical limitations. This review summarizes novel developments in volumetric imaging on the road towards clinical application to eventually monitor treatment response in patients with MS. RECENT FINDINGS: In addition to the assessment of whole-brain volume changes, recent work was focused on the volumetry of specific compartments and substructures of the central nervous system (CNS) in MS...
April 20, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29678888/bovine-spastic-syndrome-a-review
#2
REVIEW
Victoria Goeckmann, Sophie Rothammer, Ivica Medugorac
Bovine spastic syndrome (BSS) was described for the first time in 1941. The disease occurs in various-maybe even all-cattle breeds and is a chronic-progressive neuromuscular disorder that commonly affects cattle of at least three years of age. Typical clinical signs of the disease are clonic-tonic cramps of the hindlimbs that occur in attacks. Since BSS does not recover, affected animals can only be treated symptomatically by improving welfare conditions and management factors, or with physical therapy or drugs...
April 20, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#3
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29676479/sulfatide-isoform-pattern-in-cerebrospinal-fluid-discriminates-progressive-ms-from-relapsing-remitting-ms
#4
Lenka Novakova, Avadhesh Kumar Singh, Clas Malmeström, Henrik Zetterberg, Marcus Ståhlman, Markus Axelsson, Martin Adiels, Jan Borén, Jan Lycke, Susanna L Cardell, Maria Blomqvist
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Several biomarkers including proteins and lipids have been reported in MS cerebrospinal fluid (CSF), reflecting different aspects of the pathophysiology particularly of relapsing-remitting MS (RRMS). Sulfatide, abundant in the myelin sheath and a proposed target for autoimmune attack in MS, has been reported altered in MS CSF. Here, we investigated the potential of CSF sulfatide and its isoforms as biomarkers in MS...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29673365/human-central-nervous-system-astrocytes-support-survival-and-activation-of-b-cells-implications-for-ms-pathogenesis
#5
Hanane Touil, Antonia Kobert, Nathalie Lebeurrier, Aja Rieger, Philippe Saikali, Caroline Lambert, Lama Fawaz, Craig S Moore, Alexandre Prat, Jennifer Gommerman, Jack P Antel, Yasuto Itoyama, Ichiro Nakashima, Amit Bar-Or
BACKGROUND: The success of clinical trials of selective B cell depletion in patients with relapsing multiple sclerosis (MS) indicates B cells are important contributors to peripheral immune responses involved in the development of new relapses. Such B cell contribution to peripheral inflammation likely involves antibody-independent mechanisms. Of growing interest is the potential that B cells, within the MS central nervous system (CNS), may also contribute to the propagation of CNS-compartmentalized inflammation in progressive (non-relapsing) disease...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29670407/first-episode-psychosis-as-the-initial-presentation-of-multiple-sclerosis-a-case-report
#6
Athena Enderami, Rose Fouladi, Seyed Hamzeh Hosseini
Background: Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system (CNS). MS with episode of psychosis is a rare entity, and to the best of our knowledge, no case has been reported from Iran till date. Case presentation: We report a case of MS with first-episode psychosis in a 27-year-old single man with no history of psychiatric disorder or drug abuse. The patient developed neurological symptoms after 3 months and was finally diagnosed as a case of MS...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29668399/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-1-effects-on-real-world-function
#7
Victor W Mark, Edward Taub, Gitendra Uswatte, David M Morris, Gary R Cutter, Terrie L Adams, Mary H Bowman, Staci McKay
BACKGROUND: Constraint-Induced Movement therapy (CIMT) has controlled evidence of efficacy for improving real-world paretic limb use in non-progressive physically disabling disorders (stroke, cerebral palsy). OBJECTIVE: This study sought to determine whether this therapy can produce comparable results with a progressive disorder such as multiple sclerosis (MS). We conducted a preliminary phase II randomized controlled trial of CIMT versus a program of complementary and alternative medicine (CAM) treatments for persons with MS, to evaluate their effect on real-world disability...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29665800/mda-5-associated-rapidly-progressive-interstitial-lung-disease-with-recurrent-pneumothoraces-a-case-report
#8
Safi Alqatari, Peter Riddell, Sinead Harney, Michael Henry, Grainne Murphy
BACKGROUND: Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific antibodies could be negative, but with high clinical suspicion, myositis associated antibodies should be ordered. Anti-MDA-5 antibodies was reported in literature to be associated with severe and rapidly progressive interstitial lung disease, with few case reports of pneumothorax and/or pneumomediastinum...
April 17, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29664936/olfactory-dysfunction-as-a-prognostic-marker-for-disability-progression-in-multiple-sclerosis-an-olfactory-event-related-potential-study
#9
Rosella Ciurleo, Lilla Bonanno, Simona De Salvo, Laura Romeo, Carmela Rifici, Edoardo Sessa, Giangaetano D'Aleo, Margherita Russo, Placido Bramanti, Silvia Marino, Fabrizia Caminiti
Multiple sclerosis (MS) is a chronic inflammatory disease and one of the leading causes of disability in young adults. Functional markers able to predict MS progression are still lacking. It is recognized that olfactory dysfunction may be an early symptom in MS. The aim of this study was to investigate whether alterations in olfactory event-related potentials could play a prognostic role in MS. Thirty patients affected by MS relapsing-remitting underwent an olfactory potential examination (T0). Three years after baseline (T1), 28 of 30 patients were clinically evaluated by expanded disability status scale...
2018: PloS One
https://www.readbyqxmd.com/read/29664341/cervical-cord-t1-weighted-hypointense-lesions-at-mr-imaging-in-multiple-sclerosis-relationship-to-cord-atrophy-and-disability
#10
Paola Valsasina, Mohammed Aboulwafa, Paolo Preziosa, Roberta Messina, Andrea Falini, Giancarlo Comi, Massimo Filippi, Maria A Rocca
Purpose To characterize the spatial distribution of cervical cord T1-weighted hypointense lesions in patients with multiple sclerosis (MS) and analyze their association with cord atrophy and disability. Materials and Methods For this prospective study that took place between 2014 and 2016, 3.0-T high-resolution T1-weighted cervical cord magnetic resonance (MR) images and clinical evaluations were obtained from 82 patients with relapsing-remitting MS (RRMS), 33 patients with secondary progressive MS (SPMS), 25 patients with primary progressive MS (PPMS), and 35 sex-matched healthy control participants...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29663845/a-24-month-advanced-magnetic-resonance-imaging-study-of-multiple-sclerosis-patients-treated-with-alemtuzumab
#11
Irene M Vavasour, Roger Tam, David Kb Li, Cornelia Laule, Carolyn Taylor, Shannon H Kolind, Alex L MacKay, Adil Javed, Anthony Traboulsee
BACKGROUND: Tissue damage in both multiple sclerosis (MS) lesions and normal-appearing white matter (NAWM) are important contributors to disability and progression. Specific aspects of MS pathology can be measured using advanced imaging. Alemtuzumab is a humanised monoclonal antibody targeting CD52 developed for MS treatment. OBJECTIVE: To investigate changes over 2 years of advanced magnetic resonance (MR) metrics in lesions and NAWM of MS patients treated with alemtuzumab...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29663553/rapid-evidence-assessment-of-approaches-to-community-neurological-nursing-care-for-people-with-neurological-conditions-post-discharge-from-acute-care-hospital
#12
REVIEW
Judith Dianne Pugh, Kathleen McCoy, Anne M Williams, Brenda Bentley, Leanne Monterosso
Neurological conditions represent leading causes of non-fatal burden of disease that will consume a large proportion of projected healthcare expenditure. Inconsistent access to integrated healthcare and other services for people with long-term neurological conditions stresses acute care services. The purpose of this rapid evidence assessment, conducted February-June 2016, was to review the evidence supporting community neurological nursing approaches for patients with neurological conditions post-discharge from acute care hospitals...
April 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29661892/metabolic-coupling-of-axons-and-glial-cells-implications-for-multiple-sclerosis-progression
#13
Jorge Correale, María C Ysrraelit, Eduardo E Benarroch
No abstract text is available yet for this article.
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29661540/mif-functional-polymorphisms-794-catt-5-8-and-173-g-c-are-associated-with-mif-serum-levels-severity-and-progression-in-male-multiple-sclerosis-from-western-mexican-population
#14
V A Castañeda-Moreno, U De la Cruz-Mosso, N Torres-Carrillo, M A Macías-Islas, O Padilla-De la Torre, M A Mireles-Ramírez, O González-Pérez, J L Ruiz-Sandoval, M Huerta, X Trujillo, D Ortuño-Sahagún, Muñoz-Valle Jf
Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population. Therefore, we decided to investigate the genetic association of -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms with MS, clinical variables and MIF serum levels in the population of western Mexico...
April 10, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29656742/pathogenesis-of-progressive-multifocal-leukoencephalopathy-and-risks-associated-with-treatments-for-multiple-sclerosis-a-decade-of-lessons-learned
#15
REVIEW
Eugene O Major, Tarek A Yousry, David B Clifford
Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised immune systems. Detection of PML in systemically immunocompetent patients with multiple sclerosis treated with natalizumab points to a role for this drug in the pathophysiology of PML. Emerging knowledge of the cellular and molecular biology of JCV infection and the pathogenesis of PML-including interplay of this common virus with the human immune system and features of natalizumab that might contribute to PML pathogenesis-provides new opportunities to monitor viral status and predict risk of JCV-associated disease...
May 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29656271/spanish-validation-of-a-specific-measure-to-assess-work-related-problems-in-people-with-multiple-sclerosis-the-multiple-sclerosis-work-difficulties-questionnaire-mswdq-23
#16
María L Martínez-Ginés, Jose M García-Domínguez, Lucía Forero, Neus Canal, Pablo Rebollo, Daniel Prefasi, Cynthia A Honan, Jorge Maurino
INTRODUCTION: Unemployment is a significant problem for people with multiple sclerosis (MS). The MS Work Difficulties Questionnaire (MSWDQ-23) is a self-report tool to assess work-related problems in people with MS across three domains: physical, psychological/cognitive, and external barriers. The aim of this study was to assess the psychometric properties of the Spanish version of the MSWDQ-23. METHODS: A multicentre, non-interventional, cross-sectional study in adult patients with relapsing-remitting multiple sclerosis (RRMS) or primary progressive (PPMS) multiple sclerosis (McDonald 2010 criteria) was conducted...
April 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29656097/treatment-of-epilepsy-in-multiple-sclerosis
#17
Ioanna Dagiasi, Victor Vall, Eva Kumlien, Joachim Burman, Johan Zelano
PURPOSE: The prevalence of epilepsy is increased in multiple sclerosis (MS), but information on AED treatment and seizure outcome is scarce. We describe epilepsy characteristics including the use of AEDs and proportion of seizure-free patients at two tertiary hospitals in Sweden. METHOD: We retrospectively studied electronic medical records of all patients with a diagnosis of MS and seizures at Sahlgrenska university hospital and Uppsala university hospital. Clinical data were reviewed until 2017...
April 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29655870/increased-constitutive-activation-of-nf-%C3%AE%C2%BAb-p65-rela-in-peripheral-blood-cells-of-patients-with-progressive-multiple-sclerosis
#18
Jun Yan, Clay M Winterford, Vibeke S Catts, Betty K Pat, Michael P Pender, Pamela A McCombe, Judith M Greer
The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is also dysregulated in patients with progressive disease. We hypothesised that patients with progressive MS would have more activation of NF-κB than relapsing-remitting MS patients. Using several different methods, we showed that there was more nuclear translocation of p65 in cells from progressive MS patients, particularly in T cells and monocytes...
April 6, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29655371/platelet-derived-growth-factor-predicts-prolonged-relapse-free-period-in-multiple-sclerosis
#19
Mario Stampanoni Bassi, Ennio Iezzi, Girolama A Marfia, Ilaria Simonelli, Alessandra Musella, Georgia Mandolesi, Diego Fresegna, Patrizio Pasqualetti, Roberto Furlan, Annamaria Finardi, Giorgia Mataluni, Doriana Landi, Luana Gilio, Diego Centonze, Fabio Buttari
BACKGROUND: In the early phases of relapsing-remitting multiple sclerosis (RR-MS), a clear correlation between brain lesion load and clinical disability is often lacking, originating the so-called clinico-radiological paradox. Different factors may contribute to such discrepancy. In particular, synaptic plasticity may reduce the clinical expression of brain damage producing enduring enhancement of synaptic strength largely dependent on neurotrophin-induced protein synthesis. Cytokines released by the immune cells during acute inflammation can alter synaptic transmission and plasticity possibly influencing the clinical course of MS...
April 14, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29651889/how-to-conduct-research-of-rare-autoimmune-diseases
#20
Chikashi Terao
Rare autoimmune diseases are difficult to conduct researches in spite of present era with advanced scientific progress. Research using genetic approach is a promising way since genetic findings implicate causality of diseases. Still, there are multiple obstacles preventing genetic studies of rare diseases. Here, we list up the problems and propose solutions for them with detailed examples. The biggest problem is that it is difficult to collect a substantial number of DNA samples from patients with rare diseases...
April 13, 2018: Modern Rheumatology
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