keyword
https://read.qxmd.com/read/38098470/lipopolysaccharides-protect-mesenchymal-stem-cell-against-cardiac-ischemia-reperfusion-injury-by-hmgb1-stat3-signaling
#21
JOURNAL ARTICLE
Jing-Yi Wen, Hui-Xi Peng, Dan Wang, Zhi-Min Wen, Yu-Tong Liu, Jian Qu, Hong-Xuan Cui, Yu-Ying Wang, Yan-Lin DU, Ting Wang, Cong Geng, Bing Xu
BACKGROUND: Myocardial ischemia-reperfusion (I/R) is a serious and irreversible injury. Bone marrow-derived mesenchymal stem cells (MSCs) is considered to be a potential therapy for I/R injury due to the paracrine effects. High-mobility group box 1 (HMGB1) is a novel mediator in MSC and regulates the response of inflammation injury. Signal Transduction and Transcription Activator 3 (STAT3) is a critical transcription factor and important for release of paracrine factors. However, the relationship between HMGB1 and STAT3 in paracrine effect of MSC remains unknown...
November 28, 2023: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/38085649/rewiring-of-igf1-secretion-and-enhanced-igf1r-signaling-induced-by-co-chaperone-carboxyl-terminus-of-hsp70-interacting-protein-in-adipose-derived-stem-cells-provide-augmented-cardioprotection-in-aging-hypertensive-rats
#22
JOURNAL ARTICLE
Parthasarathi Barik, Wei-Wen Kuo, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Jayasimharayalu Daddam, Michael Yu-Chih Chen, V Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huang
Aging-associated cardiovascular diseases depend on the longitudinal deterioration of stem cell dynamics. The entire mechanism behind it is not completely understood. However, many studies suggest that endocrine pathways, particularly the insulin-like growth factor-1(IGF1) signaling pathway are involved in cardioprotection, especially in stem-cell treatments. Here, we investigated the role of a co-chaperone, carboxyl-terminus of Hsp70 interacting protein (CHIP) in the aspects of growth factor secretion and receptor stabilization in mesenchymal stem cells (MSCs)...
December 11, 2023: Aging
https://read.qxmd.com/read/38069578/a-comprehensive-review-of-the-novel-therapeutic-targets-for-the-treatment-of-diabetic-cardiomyopathy
#23
REVIEW
Arti Dhar, Jegadheeswari Venkadakrishnan, Utsa Roy, Sahithi Vedam, Nikita Lalwani, Kenneth S Ramos, Tej K Pandita, Audesh Bhat
Diabetic cardiomyopathy (DCM) is characterized by structural and functional abnormalities in the myocardium affecting people with diabetes. Treatment of DCM focuses on glucose control, blood pressure management, lipid-lowering, and lifestyle changes. Due to limited therapeutic options, DCM remains a significant cause of morbidity and mortality in patients with diabetes, thus emphasizing the need to develop new therapeutic strategies. Ongoing research is aimed at understanding the underlying molecular mechanism(s) involved in the development and progression of DCM, including oxidative stress, inflammation, and metabolic dysregulation...
2023: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38045353/loss-of-cardiac-pfkfb2-drives-metabolic-functional-and-electrophysiological-remodeling-in-the-heart
#24
Kylene M Harold, Satoshi Matsuzaki, Atul Pranay, Brooke L Loveland, Albert Batushansky, Maria F Mendez Garcia, Craig Eyster, Stavros Stavrakis, Ying Ann Chiao, Michael Kinter, Kenneth M Humphries
BACKGROUND: Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK-2, is degraded in the heart in the absence of insulin signaling, contributing to diabetes-induced cardiac metabolic inflexibility. However, previous studies have not examined how the loss of PFKFB2 affects global cardiac metabolism and function. METHODS: To address this, we have generated a mouse model with a cardiomyocyte-specific knockout of PFKFB2 (cKO)...
November 23, 2023: bioRxiv
https://read.qxmd.com/read/37940431/sodium-glucose-co-transporter-2-inhibitor-canagliflozin-modulates-myocardial-metabolism-and-inflammation-in-a-swine-model-for-chronic-myocardial-ischemia
#25
JOURNAL ARTICLE
Dwight D Harris, Sharif A Sabe, Cynthia M Xu, Mohamed Sabra, Mark Broadwin, Akshay Malhotra, Janelle W Li, M Ruhul Abid, Frank W Sellke
BACKGROUND: Inflammation and disruption of cardiac metabolism are prevalent in the setting of myocardial ischemia. Canagliflozin, a sodium-glucose costransporter-2 inhibitor, has beneficial effects on the heart, though the precise mechanisms are unknown. This study investigated the effects of canagliflozin therapy on metabolic pathways and inflammation in ischemic myocardial tissue using a swine model of chronic myocardial ischemia. METHODS: Sixteen Yorkshire swine underwent placement of an ameroid constrictor to the left circumflex artery to induce chronic ischemia...
November 6, 2023: Surgery
https://read.qxmd.com/read/37894760/mtorc1-and-sglt2-inhibitors-a-therapeutic-perspective-for-diabetic-cardiomyopathy
#26
REVIEW
Sumit Saha, Xianjun Fang, Christopher D Green, Anindita Das
Diabetic cardiomyopathy is a critical diabetes-mediated co-morbidity characterized by cardiac dysfunction and heart failure, without predisposing hypertensive or atherosclerotic conditions. Metabolic insulin resistance, promoting hyperglycemia and hyperlipidemia, is the primary cause of diabetes-related disorders, but ambiguous tissue-specific insulin sensitivity has shed light on the importance of identifying a unified target paradigm for both the glycemic and non-glycemic context of type 2 diabetes (T2D)...
October 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37891701/glucose-fluctuations-aggravate-myocardial-fibrosis-via-activating-the-camkii-stat3-signaling-in-type-2-diabtetes
#27
JOURNAL ARTICLE
Lei Zhang, Huan-Huan Liu, Fan Yang, Zhi-Yuan Zhang, Zhen-Ye Zhang, Xiao-Xi Zhao, Ling-Ling Qian, Shi-Peng Dang, Ru-Xing Wang
BACKGROUND: Glucose fluctuations (GF) are a risk factor for cardiovascular complications associated with type 2 diabetes. However, there is a lack of adequate research on the effect of GF on myocardial fibrosis and the underlying mechanisms in type 2 diabetes. This study aimed to investigate the impact of glucose fluctuations on myocardial fibrosis and explore the potential mechanisms in type 2 diabetes. METHODS: Sprague Dawley (SD) rats were randomly divided into three groups: the control (Con) group, the type 2 diabetic (DM) group and the glucose fluctuations (GF) group...
October 28, 2023: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/37891673/dual-roles-of-myocardial-mitochondrial-akt-on-diabetic-cardiomyopathy-and-whole-body-metabolism
#28
JOURNAL ARTICLE
Yu-Han Chen, Albert P Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C Jordan, Kenneth P Roos, Grant R MacGregor, Qin Yang, Robert A Edwards, Junfeng Li, Ping H Wang
BACKGROUND: The PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated phospho-AKT also translocates to mitochondria in the myocardium. Mouse models of diabetes exhibit impaired mitochondrial AKT signaling but the implications of this on cardiac structure and function is unknown. We hypothesized that loss of mitochondrial AKT signaling is a critical step in cardiomyopathy and reduces cardiac oxidative phosphorylation...
October 27, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/37885804/comparison-of-western-diet-induced-obesity-and-streptozotocin-mouse-models-insights-into-energy-balance-somatosensory-dysfunction-and-cardiac-autonomic-neuropathy
#29
JOURNAL ARTICLE
Nadia Elshareif, Emily Gornick, Chaitanya K Gavini, Gregory Aubert, Virginie Mansuy-Aubert
Metabolic disorders such as obesity and type 2 diabetes (T2D) are increasingly prevalent worldwide, necessitating a deeper comprehension of their underlying mechanisms. However, translating findings from animal research to human patients remains challenging. This study aimed to investigate the long-term effects of Streptozotocin (STZ) on metabolic, cardiac, and somatosensory function in mice fed a Western diet (WD) of high fat, sucrose, and cholesterol with low doses of STZ administration compared to mice fed WD alone...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37882731/cd36-as-a-gatekeeper-of-myocardial-lipid-metabolism-and-therapeutic-target-for-metabolic-disease
#30
REVIEW
Jan F C Glatz, Lisa C Heather, Joost J F P Luiken
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and plays a key regulatory role in cellular lipid metabolism. CD36 facilitates the cellular uptake of long-chain fatty acids, mediates lipid signaling, and regulates storage and oxidation of lipids in various tissues with active lipid metabolism. CD36 deficiency leads to marked impairments in peripheral lipid metabolism, which consequently impacts on the cellular utilization of multiple different fuels, due to the integrated nature of metabolism...
October 26, 2023: Physiological Reviews
https://read.qxmd.com/read/37856903/angiotensin-ii-type-1-receptor-associated-protein-in-immune-cells-a-possible-key-factor-in-the-pathogenesis-of-visceral-obesity
#31
JOURNAL ARTICLE
Shunichiro Tsukamoto, Toru Suzuki, Hiromichi Wakui, Tatsuki Uehara, Juri Ichikawa, Hiroshi Okuda, Kotaro Haruhara, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Sho Kinguchi, Akio Yamashita, Tomohiko Tamura, Kouichi Tamura
BACKGROUND AND AIM: Dysregulation of angiotensin II type 1 receptor-associated protein (ATRAP) expression in cardiovascular, kidney, and adipose tissues is involved in the pathology of hypertension, cardiac hypertrophy, atherosclerosis, kidney injury, and metabolic disorders. Furthermore, ATRAP is highly expressed in bone marrow-derived immune cells; however, the functional role of immune cell ATRAP in obesity-related pathology remains unclear. Thus, we sought to identify the pathophysiological significance of immune cell ATRAP in the development of visceral obesity and obesity-related metabolic disorders using a mouse model of diet-induced obesity...
October 13, 2023: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/37851320/compromised-diabetic-heart-function-is-not-affected-by-mir-378a-upregulation-upon-hyperglycemia
#32
JOURNAL ARTICLE
Urszula Florczyk-Soluch, Katarzyna Polak, Reece Sabo, Alicja Martyniak, Jacek Stępniewski, Józef Dulak
BACKGROUND: Cardiac-abundant microRNA-378a (miR-378a) is associated with postnatal repression of insulin-like growth factor 1 receptor (IGF-1R) controlling physiological hypertrophy and survival pathways. IGF-1/IGF-1R axis has been proposed as a therapeutic candidate against the pathophysiological progress of diabetic cardiomyopathy (DCM). We ask whether hyperglycemia-driven changes in miR-378a expression could mediate DCM progression. METHODS: Diabetes mellitus was induced by streptozotocin (STZ) (55 mg/kg i...
October 18, 2023: Pharmacological Reports: PR
https://read.qxmd.com/read/37829282/epigenome-wide-dna-methylation-profiling-in-comparison-between-pathological-and-physiological-hypertrophy-of-human-cardiomyocytes
#33
JOURNAL ARTICLE
Hangchuan Shi, Si Chen, Fanju W Meng, Deborah J Ossip, Chen Yan, Dongmei Li
Background: Physiological and pathological stimuli result in distinct forms of cardiac hypertrophy, but the molecular regulation comparing the two, especially at the DNA methylation level, is not well understood. Methods: We conducted an in vitro study using human cardiomyocytes exposed to angiotensin II (AngII) and insulin-like growth factor 1 (IGF-1) to mimic pathologically and physiologically hypertrophic heart models, respectively. Whole genome DNA methylation patterns were profiled by the Infinium human MethylationEPIC platform with >850 K DNA methylation loci...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37774805/fgf21-protects-against-doxorubicin-induced-cardiotoxicity-by-inhibiting-connexin-43-ubiquitination
#34
JOURNAL ARTICLE
Ying Huang, Chenchen Wei, Ping Li, Yaqing Shao, Min Wang, Feng Wang, Guanghao Niu, Kangyun Sun, Qian Zhang, Zhongshan Gou, Xinxin Yan
BACKGROUND: Fibroblast growth factor 21 (FGF21) regulates glycolipid metabolism and insulin homeostasis and acts as a cardioprotective factor by protecting against myocardial ischemia/reperfusion injury, hypertension, and vascular dysfunction. FGF21 has been reported to prevent Doxorubicin (Dox)-induced cardiotoxicity, and the related signaling pathway is worthy of further study. Connexin43 (Cx43) protein was reduced by Dox treatment, especially low phosphorylated form of Cx43. Thus the aim of study is to explore the protection effect of FGF21 on Dox induced cardiotoxicity by improving the expression of Cx43 and the involved signaling pathway...
November 1, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/37739320/diabetic-cardiomyopathy-zinc-preventive-and-therapeutic-potentials-by-its-anti-oxidative-stress-and-sensitizing-insulin-signaling-pathways
#35
JOURNAL ARTICLE
Lu Cai, Yi Tan, Sara Watson, Kupper Wintergerst
Oxidative stress and insulin resistance are two key mechanisms for the development of diabetic cardiomyopathy (DCM, cardiac remodeling and dysfunction). In this review, we discussed how zinc and metallothionein (MT) protect the heart from type 1 or type 2 diabetes (T1D or T2D) through its anti-oxidative function and insulin-mediated PI3K/Akt signaling activation. Both T1D and T2D-induced DCM, shown by cardiac structural remodeling and dysfunction, in wild-type mice, but not in cardiomyocyte-specific overexpressing MT mice...
September 20, 2023: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/37726973/role-of-the-tripartite-motif-containing-trim-family-of-proteins-in-insulin-resistance-and-related-disorders
#36
REVIEW
Jianrong Chen, Xianjie Feng, Xu Zhou, Yong Li
Emerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as type 2 diabetes mellitus, obesity, nonalcoholic fatty liver disease, and atherosclerosis...
September 19, 2023: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/37725888/accumulation-of-endogenous-adenosine-improves-cardiomyocyte-metabolism-via-epigenetic-reprogramming-in-an-ischemia-reperfusion-model
#37
JOURNAL ARTICLE
Peng Wang, Rifeng Gao, Tingting Wu, Jinyan Zhang, Xiaolei Sun, Fan Fan, Cong Wang, Sanli Qian, Bingyu Li, Yunzeng Zou, Yuqing Huo, John Fassett, Yingjie Chen, Junbo Ge, Aijun Sun
Adenosine kinase (ADK) plays the major role in cardiac adenosine metabolism, so that inhibition of ADK increases myocardial adenosine levels. While the cardioprotective actions of extracellular adenosine against ischemia/reperfusion (I/R) are well-established, the role of cellular adenosine in protection against I/R remains unknown. Here we investigated the role of cellular adenosine in epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to I/R. Evans blue/TTC staining and echocardiography were used to assess the extent of I/R injury in mice...
September 13, 2023: Redox Biology
https://read.qxmd.com/read/37721135/insulin-like-growth-factor-1-receptor-deficiency-alleviates-angiotensin-ii-induced-cardiac-fibrosis-through-the-protein-kinase-b-extracellular-signal-regulated-kinase-nuclear-factor-%C3%AE%C2%BAb-pathway
#38
JOURNAL ARTICLE
Jiafeng Zhu, Qian Li, Yan Sun, Shiyu Zhang, Ruiyan Pan, Yanguang Xie, Jinyan Chen, Lihong Shi, Yanbo Chen, Zhipeng Sun, Lane Zhang
Background The renin-angiotensin system plays a crucial role in the development of heart failure, and Ang II (angiotensin II) acts as the critical effector of the renin-angiotensin system in regulating cardiac fibrosis. However, the mechanisms of cardiac fibrosis are complex and still not fully understood. IGF1R (insulin-like growth factor 1 receptor) has multiple functions in maintaining cardiovascular homeostasis, and low-dose IGF1 treatment is effective in relieving Ang II-induced cardiac fibrosis. Here, we aimed to investigate the molecular mechanism of IGF1R in Ang II-induced cardiac fibrosis...
September 19, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37721125/exercise-ameliorating-myocardial-injury-in-type-2-diabetic-rats-by-inhibiting-excessive-mitochondrial-fission-involving-increased-irisin-expression-and-amp-activated-protein-kinase-phosphorylation
#39
JOURNAL ARTICLE
Bin Wang, Chen Zhao, Yuanxin Wang, Xin Tian, Junjie Lin, Baishu Zhu, Yalan Zhou, Xin Zhang, Nan Li, Yu Sun, Haocheng Xu, Renqing Zhao
PURPOSE: Though exercise generates beneficial effects on diabetes-associated cardiac damage, the underlying mechanism is largely unclear. Therefore, we prescribed a program of 8-week treadmill training for type 2 diabetes mellitus (T2DM) rats and determined the role of irisin signaling, via interacting with AMP-activated protein kinase (AMPK), in mediating the effects of exercise on myocardial injuries and mitochondrial fission. METHODS: Forty 8-week-old male Wistar rats were randomly divided into groups of control (Con), diabetes mellitus (DM), diabetes plus exercise (Ex), and diabetes plus exercise and Cyclo RGDyk (ExRg)...
September 18, 2023: Journal of Diabetes
https://read.qxmd.com/read/37720055/arrhythmogenic-ca-2-signaling-in-a-metabolic-model-of-hfpef
#40
Aaron D Kaplan, Liron Boyman, Christopher W Ward, W Jonathan Lederer, Maura Greiser
Heart failure with preserved ejection fraction (HFpEF) already represents approximately 50% of all cases of heart failure and its incidence continues to rise. Initially regarded as a disorder of hypertensive left ventricular dysfunction in older adults, HFpEF has emerged as a complex cardiometabolic syndrome in younger adults associated with other co-morbidities such as obesity, decreased insulin sensitivity, dyslipidemia and others. An important part of the high morbidity and mortality associated with HFpEF is a high rate of sudden cardiac death (∼ 25%) and malignant arrhythmias whose underlying mechanisms remain poorly understood...
June 24, 2023: bioRxiv
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