Tianqi Duo, Xiaohong Liu, Delin Mo, Yu Bian, Shufang Cai, Min Wang, Ruiqiang Li, Qi Zhu, Xian Tong, Ziyun Liang, Weilun Jiang, Shiyi Chen, Yaosheng Chen, Zuyong He
BACKGROUND: Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness...
November 2, 2023: Journal of Animal Science and Biotechnology