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https://www.readbyqxmd.com/read/27933686/risk-of-incident-mycobacterium-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-a-nationwide-population-based-study-in-south-korea
#1
S N Hong, H J Kim, K H Kim, S-J Han, I M Ahn, H S Ahn
BACKGROUND: The low incidence of Mycobacterium tuberculosis infection and lack of adequate controls have prevented researchers from estimating tuberculosis (TB) risk in inflammatory bowel disease (IBD) patients. AIM: To evaluate the risk of incident TB among IBD patients. METHODS: Using the 2011-2013 data of the South Korean National Health Insurance (NHI) system, we calculated the incidence rates (IRs), standardised incidence ratio (SIR) and number needed to screen (NNS) for incident TB in IBD patients compared to the general population in terms of subtype, age, gender and IBD medications...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27933551/pentoxifylline-alleviates-early-brain-injury-after-experimental-subarachnoid-hemorrhage-in-rats-possibly-via-inhibiting-tlr-4-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Da-Yong Xia, Hua-Sheng Zhang, Ling-Yun Wu, Xiang-Sheng Zhang, Meng-Liang Zhou, Chun-Hua Hang
Early brain injury (EBI) after subarachnoid hemorrhage (SAH) generally causes significant and lasting damage. Pentoxifylline (PTX), a nonselective phosphodiesterase inhibitor, has shown anti-inflammatory and neuroprotective properties in several brain injury models, but the role of PTX with respect to EBI following SAH remains uncertain. The purpose of this study was to investigate the effects of PTX on EBI after SAH in rats. Adult male Sprauge-Dawley rats were randomly assigned to the sham and SAH groups. PTX (30 or 60 mg/kg) or an equal volume of the administration vehicle (normal saline) was administrated at 30 min intervals following SAH...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27933547/anti-neuroinflammatory-effects-of-fucoxanthin-via-inhibition-of-akt-nf-%C3%AE%C2%BAb-and-mapks-ap-1-pathways-and-activation-of-pka-creb-pathway-in-lipopolysaccharide-activated-bv-2-microglial-cells
#3
Dong Zhao, Seung-Hwan Kwon, Yoon Sun Chun, Ming-Yao Gu, Hyun Ok Yang
Microglia play a critical role in controlling the homeostasis of the brain, but over-activated microglia secrete pro-inflammatory mediators and cytokines, which induce neuronal cell death. Fucoxanthin (Fx), a marine carotenoid, has demonstrated a variety of beneficial health effects. Despite accumulating evidence supporting the immune-modulating effects of Fx in vitro, the underlying signaling pathways remain unknown. In the present study, Fx dose-dependently inhibited the secretion of lipopolysaccharide (LPS)-induced pro-inflammatory mediators including interleukin (IL)-6, tumor necrosis factor (TNF)-α, reactive oxygen species (ROS), prostaglandin (PG) E2, and nitric oxide (NO) productions, and also suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzymes...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27933472/tumor-necrosis-factor-alpha-inhibitors-did-not-influence-postoperative-morbidity-after-elective-surgical-resections-in-crohn-s-disease
#4
Paulo Gustavo Kotze, Mansur Paulo Saab, Bárbara Saab, Lorete Maria da Silva Kotze, Marcia Olandoski, Lilian Vital Pinheiro, Carlos Augusto Real Martinez, Maria de Lourdes Setsuko Ayrizono, Daniela de Oliveira Magro, Claudio Saddy Rodrigues Coy
BACKGROUND: The real impact of anti-tumor necrosis alpha (TNF) therapy in postoperative complications after intestinal resections in Crohn's disease (CD) still needs to be determined. AIMS: To compare the postoperative complication rates after elective intestinal resections in CD patients, with or without previous exposure to anti-TNF therapy. METHODS: This was a retrospective and observational study, with elective intestinal resections for CD (emergency procedures were excluded)...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933061/ncr1-expression-identifies-canine-natural-killer-cell-subsets-with-phenotypic-similarity-to-human-natural-killer-cells
#5
Jennifer A Foltz, Srinivas S Somanchi, Yanwen Yang, Arianexys Aquino-Lopez, Erin E Bishop, Dean A Lee
Canines spontaneously develop many cancers similar to humans - including osteosarcoma, leukemia, and lymphoma - offering the opportunity to study immune therapies in a genetically heterogeneous and immunocompetent environment. However, a lack of antibodies recognizing canine NK cell markers has resulted in suboptimal characterization and unknown purity of NK cell products, hindering the development of canine models of NK cell adoptive immunotherapy. To this end, we generated a novel antibody to canine NCR1 (NKp46), the putative species-wide marker of NK cells, enabling purification of NK cells for further characterization...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27932936/riboflavin-along-with-antibiotics-balances-reactive-oxygen-species-and-inflammatory-cytokines-and-controls-staphylococcus-aureus-infection-by-boosting-murine-macrophage-function-and-regulates-inflammation
#6
Somrita Dey, Biswadev Bishayi
BACKGROUND: Macrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphylococci may play an important role in the pathogenesis. Since this localization protects them from both cell-mediated and humoral immune responses, therefore, a successful anti-staphylococcal therapy should include the elimination of intracellular bacteria, further protecting the host cells from staphylococci-induced cell death...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27932702/incorporation-of-cerium-oxide-into-hydroxyapatite-coating-regulates-osteogenic-activity-of-mesenchymal-stem-cell-and-macrophage-polarization
#7
Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang, Xuebin Zheng
Biomedical coatings for orthopedic implants should facilitate osseointegration and mitigate implant-induced inflammatory reactions. Cerium oxide (CeO2) ceramics possess anti-oxidative properties and can be used to decrease mediators of inflammation, which makes them attractive for biomedical applications. In our work, two kinds of CeO2 incorporated hydroxyapatite coatings (HA-10Ce and HA-30Ce) were prepared via plasma spraying technique and the effects of CeO2 addition on the responses of bone mesenchymal stem cells (BMSCs) and RAW264...
December 8, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27932454/inducible-colonic-m-cells-are-dependent-on-tnfr2-but-not-lt%C3%AE-r-identifying-distinct-signaling-requirements-for-constitutive-versus-inducible-m-cells
#8
Erinn A Parnell, Erin M Walch, David D Lo
BACKGROUND AND AIMS: M cells associated with organized lymphoid tissues such as intestinal Peyer's patches provide surveillance of the intestinal lumen. Inflammation or infection in the colon can induce an M cell population associated with lymphoid infiltrates; paradoxically, induction is dependent on the inflammatory cytokine Tumor Necrosis Factor (TNF)-α. Anti-TNFα blockade is an important therapeutic in Inflammatory Bowel Disease, so understanding the effects of TNFα signaling is important in refining therapeutics...
December 7, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27932278/patient-perceived-flares-in-rheumatoid-arthritis-a-sub-analysis-of-the-strass-treatment-tapering-strategy-trial
#9
Agnès Portier, Laure Gossec, Florence Tubach, Toni Alfaiate, Thao Pham, Alain Saraux, Martin Soubrier, Thierry Schaeverbeke, Jean-Francis Maillefert, Xavier Mariette, David Hajage, Bruno Fautrel
OBJECTIVES: Patient's and physician's perspective can differ in rheumatoid arthritis (RA). The aim was to define the concept of patient-reported flares. METHODS: Post-hoc analysis of a randomized controlled trial of a step-down strategy in RA patients treated with anti-TNF, in DAS28-remission for ≥6 months, randomized to either "spacing" or "maintaining" anti-TNF. The occurrence of patient-reported flares (PRF) was evaluated every 3 months for 18 months by: "Over the last 3 months, did you experience symptoms suggestive of disease exacerbation?"...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27931220/native-musk-and-synthetic-musk-ketone-strongly-induced-the-growth-repression-and-the-apoptosis-of-cancer-cells
#10
Ling Xu, Yi Cao
BACKGROUND: Musk is widely used in clinical practice for its anti-cancer properties. Here, we treated various types of cancer using musk to determine which cancers are sensitive to musk treatment. We also compared effects of native musk and synthetic musk ketone in cancer cells. Furthermore, we investigated mechanisms underlying effects of musk. METHODS: Twenty two cancer cell lines were treated with musk. Cell proliferation and apoptosis analyses were carried out...
December 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27931132/guillain-barr%C3%A3-syndrome-during-adalimumab-therapy-for-crohn%C3%A2-s-disease-coincidence-or-consequence
#11
Guilherme Grossi Lopes Cançado, Eduardo Garcia Vilela
We report the case of a 64-year-old patient diagnosed with extensive ileal Crohn´s disease who developed Guillain-Barré syndrome after starting biological therapy with adalimumab. Neurologic involvement associated with inflammatory bowel diseases is recognized as an extra-intestinal manifestation. After the breakthrough of antitumor necrosis factor alpha (anti-TNF-α) agents, an increasing number of cases of acute inflammatory demyelinating polyneuropathies have been reported; however, only one case has been described in a patient with Crohn´s disease...
December 8, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27931102/mannose-receptor-mediates-the-immune-response-to-ganoderma-atrum-polysaccharides-in-macrophages
#12
Wen-Juan Li, Xiao-Fang Tang, Xiao-Xue Shuai, Cheng-Jia Jiang, Xiang Liu, Le-Feng Wang, Yu-Fei Yao, Shaoping Nie, Ming-Yong Xie
The ability of mannose receptor (MR) to recognize the carbohydrate structures is well established. Here we reported that MR was crucial for the immune response to Ganoderma atrum polysaccharides (PSG-1), as evidenced by elevation of MR in association with increase of phagocytosis and concentrations of IL-1ß and TNF-α in normal macrophages. Elevation of MR triggered by PSG-1 also led to control lipopolysaccharide (LPS)-triggered inflammatory response via the increase of IL-10 and inhibition of phagocytosis and IL-1ß...
December 8, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27930985/c1q-tnf-related-protein-3-exerts-the-chondroprotective-effects-in-il-1%C3%AE-treated-sw1353-cells-by-regulating-the-fgfr1-signaling
#13
Yuanxia Huang, Guang Wan, Jingang Tao
Cartilage degeneration is known as a major cause of osteoarthritis (OA). C1q/TNF-related protein-3 (CTRP3) is an adipokine relative to chondrogenesis in vitro. However, its effect on cartilage degeneration in OA remains unclearly. In the present study, SW1353 cells were treated with IL-1β to imitate the microenvironment of OA for vitro research. Then, an obvious down-regulation of CTRP3 were validated in IL-1β-treated SW1353 cells. In addition, CTRP3 overexpression significantly attenuated the decrease in cell proliferation and increase in cell apoptosis triggered by IL-1β...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930969/rhapontin-ameliorates-colonic-epithelial-dysfunction-in-experimental-colitis-through-sirt1-signaling
#14
Wencheng Wei, Lei Wang, Kai Zhou, Haifeng Xie, Mian Zhang, Chaofeng Zhang
Rhapontin (3, 3', 5-trihydroxy-4'-methoxystilbene-3-O-glucoside) has anti-thrombotic, anti-allergic and anti-diabetic activities. This study aimed to assess the protective effects of rhapontin on intestinal damage in vivo and in vitro. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of rhapontin (100mg/kg) significantly attenuated colonic pathological damage and remarkably inhibited infiltration by inflammatory cells, myeloperoxidase (MPO) activity, NLRP3 inflammasome activation and SIRT1 expression in the colon...
December 5, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27930815/ctrp-3-is-permeable-to-the-blood-brain-barrier-and-is-not-regulated-by-glucose-or-lipids-in-vivo
#15
Andreas Schmid, Martin Berghoff, Alexandra Hochberg, Andreas Schäffler, Thomas Karrasch
C1q/TNF-related protein-3 (CTRP-3) represents a novel anti-inflammatory and anti-diabetic adipokine secreted by adipose tissue. The physiological and postprandial regulation of CTRP-3 remains obscure and it is not known whether CTRP-3 is permeable to the brain AIM: The postprandial regulation of CTRP-3 during an oral glucose tolerance test (n=100) and an oral lipid tolerance test (n=100) in humans was investigated. Moreover, CTRP-3 concentrations were measured in paired serum and cerebrospinal fluid (CSF) samples of patients (n=270) undergoing neurological evaluation...
December 8, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27930719/in-vitro-and-in-vivo-anti-allergic-and-anti-inflammatory-effects-of-ebv-a-newly-developed-derivative-of-bee-venom-through-modulation-of-irf3-signaling-pathway-in-a-carrageenan-induced-edema-model
#16
Hwa-Jin Chung, Jinho Lee, Joon-Shik Shin, Me-Riong Kim, Wonil Koh, Min-Jeong Kim, Jae-Woong Lee, Eun Jee Kim, In-Hee Lee, Won Kyung Kim, Yoon Jae Lee, Sang Kook Lee, In-Hyuk Ha
BACKGROUND: Bee venom (BV), a type of toxin extracted from honeybees (Apis mellifera), has been empirically and widely used to treat inflammatory diseases throughout Asia. Essential BV (eBV) was developed by removing phospholipase A2 (PLA2) and histamine to lower occurrence of allergic reaction. This study investigated the anti-allergic and anti-inflammatory activities of eBV in vitro and in vivo and its underlying mechanism of action. METHODS: The anti-inflammatory potential of eBV was assessed in vivo using a carrageenan-induced paw edema model...
2016: PloS One
https://www.readbyqxmd.com/read/27930541/cytotoxic-th1-and-th17-cells-infiltrate-the-intestinal-mucosa-of-behcet-patients-and-exhibit-high-levels-of-tnf-%C3%AE-in-early-phases-of-the-disease
#17
Giacomo Emmi, Elena Silvestri, Chiara Della Bella, Alessia Grassi, Marisa Benagiano, Fabio Cianchi, Danilo Squatrito, Luca Cantarini, Lorenzo Emmi, Carlo Selmi, Domenico Prisco, Mario Milco D'Elios
BACKGROUND: Gastrointestinal involvement is one of the most serious in Behçet disease, potentially leading to severe complications. Aim of this study was to investigate at mucosal level the T-cell responses in Behçet patients with early intestinal involvement. METHODS: We isolated T cells from intestinal mucosa of 8 patients with intestinal symptoms started within 6 months. T lymphocytes were cloned and analyzed for surface phenotype and cytokines production. RESULTS: We obtained 382 T-cell clones: 324 were CD4+ and 58 were CD8+...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930350/toll-like-receptor-tlr-4-and-myd88-are-essential-for-atheroprotection-by-peritoneal-b1a-b-cells
#18
Hamid Hosseini, Yi Li, Peter Kanellakis, Christopher Tay, Anh Cao, Edgar Liu, Karlheinz Peter, Peter Tipping, Ban-Hock Toh, Alex Bobik, Tin Kyaw
BACKGROUND: We previously identified peritoneal B1a cells that secrete natural IgM as a key atheroprotective B cell subset. However, the molecules that activate atheroprotective B1a cells are unknown. Here, we investigated whether Toll-like receptors (TLRs) TLR2, TLR4, and TLR9 expressed by B1a cells are required for IgM-mediated atheroprotection. METHODS AND RESULTS: We adoptively transferred B1a cells from wild-type mice or from mice deficient in TLR2, TLR4, TLR9, or myeloid differentiation primary response 88 (MyD88) into ApoE(-/-) mice depleted of peritoneal B1a cells by splenectomy and fed a high-fat diet for 8 weeks...
November 14, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27929524/rapid-test-for-infliximab-drug-concentration-allows-immediate-dose-adaptation
#19
Thomas Van Stappen, Lize Bollen, Niels Vande Casteele, Konstantinos Papamichael, Gert Van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
OBJECTIVES: Therapeutic drug monitoring of infliximab improves treatment outcomes, but available assays to monitor infliximab lack speed to implement treatment algorithms immediately. Our aim is to validate a rapid, lateral flow-based assay (LFA) for quantitative determination of infliximab and to assess thresholds associated with mucosal healing in patients with ulcerative colitis. METHODS: Samples (n=190) from 29 anti-tumor necrosis factor naive patients with ulcerative colitis starting infliximab induction therapy between June 2010 and February 2012 were prospectively collected...
December 8, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27929393/xylobiose-an-alternative-sweetener-ameliorates-diabetes-related-metabolic-changes-by-regulating-hepatic-lipogenesis-and-mir-122a-33a-in-db-db-mice
#20
Eunjin Lim, Ji Ye Lim, Eunju Kim, Yoo-Sun Kim, Jae-Ho Shin, Pu Reum Seok, Sangwon Jung, Sang-Ho Yoo, Yuri Kim
Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules of d-xylose and is a major disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized that XB could regulate diabetes-related metabolic and genetic changes via microRNA expression in db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% XB as part of the total sucrose content of their diet. XB supplementation improved glucose tolerance with reduced levels of OGTT AUC, fasting blood glucose, HbA1c, insulin, and HOMA-IR...
December 5, 2016: Nutrients
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