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https://www.readbyqxmd.com/read/29131373/differentially-expressed-mirna-210-during-follicular-luteal-transition-regulates-pre-ovulatory-granulosa-cell-function-targeting-hras-and-efna3
#1
Astha Shukla, Sunita Dahiya, Suneel Kumar Onteru, Dheer Singh
Ovarian folliculogenesis, ovulation and luteinization are an important prerequisite for fertility performance in mammals. Spatial and temporal key factors and proteins for their regulation are well known. Recent advancement in the field of molecular biology led to the discovery of another class of gene regulators, microRNA (miRNA). Previous studies on profiling of miRNA in buffalo ovaries revealed that miRNA-210 (miR-210) is differently expressed in follicular-luteal transition. Therefore, the present study was planned to ascertain the role of miR-210 in buffalo granulosa cells...
November 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29113261/rs1008805-polymorphism-of-cyp19a1-gene-is-associated-with-the-efficacy-of-hormone-therapy-in-stage-i-ii-and-operable-stage-iii-breast-cancer
#2
Xiying Shao, Lei Luo, Yong Guo, Xiaohong Xu, Dehou Deng, Jianguo Feng, Yuheng Ding, Hanzhou Mou, Ping Huang, Lei Shi, Yuan Huang, Weiwu Ye, Caijin Lou, Zhanhong Chen, Yabing Zheng, Xiaojia Wang
It has been hypothesized that single nucleotide polymorphisms in CYP19A1 gene may alter aromatase activity and circulating steroid hormone levels in females. Therefore, it is biologically reasonable that CYP19A1 rs1008805 (A/G) polymorphism may be associated with the clinical outcome of hormone therapy. Genotyping for the CYP19A1 rs1008805 polymorphism was performed for 287 females with hormone receptor (HR)-positive early breast cancer, and potential associations were evaluated between CYP19A1 rs1008805 genotypes and disease-free survival (DFS)...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29089286/an-investigation-of-the-single-and-combined-phthalate-metabolite-effects-on-human-chorionic-gonadotropin-expression-in-placental-cells
#3
Jennifer J Adibi, Yaqi Zhao, Lei V Zhan, Mirhan Kapidzic, Nicholas Larocque, Hannu Koistinen, Ilpo T Huhtaniemi, Ulf-Håkan Stenman
BACKGROUND: Observational studies have reported associations between maternal phthalate levels and adverse outcomes at birth and in the health of the child. Effects on placental function have been suggested as a biologic basis for these findings. OBJECTIVE: We evaluated the effects of phthalates on placental function in vitro by measuring relevant candidate genes and proteins. MATERIALS AND METHODS: Human trophoblast progenitor cells were isolated at 7-14 wk of pregnancy (two female and three male concepti), and villous cytotrophoblast cells (vCTBs) were isolated at 15-20 wk (three female and four male concepti)...
October 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29089199/microrna-27a-3p-affects-estradiol-and-androgen-imbalance-by-targeting-creb1-in-the-granulosa-cells-in-mouse-polycytic-ovary-syndrome-model
#4
Mingming Wang, Mei Liu, Jing Sun, Lina Jia, Shuoqian Ma, Jun Gao, Yunyun Xu, Hongwen Zhang, Suk Ying Tsang, Xiangdong Li
Polycystic ovary syndrome (PCOS) is a common endocrine abnormality in women characterized by a menstrual disturbance with chronic anovulation and hyperandrogenism, polycystic ovaries, and insulin resistance. MicroRNAs (miRNAs) are important fine-tune regulators involved in various physiological and pathological processes, but their actions are not fully understood. In this study, we observed the increased expression of miR-27a-3p in the ovaries of mice with PCOS and explored its functions in primary mouse granulosa cells (mGCs) and the mouse granulosa-like tumor cell line, KK-1, using several approaches...
October 28, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29066910/cyp19a1-gene-polymorphism-and-colorectal-cancer-etiology-in-saudi-population-case-control-study
#5
Fatimah Basil Al-Mukaynizi, Mohammed Alanazi, Sooad Al-Daihan, Narasimha Reddy Parine, Majid Almadi, Abdulrahman Aljebreen, Nahla Azzam, Othman Alharbi, Maha Arafah, Arjumand Warsy
BACKGROUND: Considerable interest is directed toward the enzyme aromatase (CYP19A1) and the development of cancer, due to CYP19A1's role in estrogen biosynthesis. Several cancers display excessive intra-tumor accumulation of estrogens, and aromatase inhibitors are used for treatment. The CYP19A1 gene exhibits polymorphism and mutations that can alter its expression or aromatase activity and influence estrogen production. We designed this study to investigate the link between CYP19A1 polymorphism and susceptibility to colorectal cancer (CRC) development in Saudis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29037132/expression-of-hormonal-carcinogenesis-genes-and-related-regulatory-micrornas-in-uterus-and-ovaries-of-ddt-treated-female-rats
#6
T S Kalinina, V V Kononchuk, L F Gulyaeva
The insecticide dichlorodiphenyltrichloroethane (DDT) is a nonmutagenic xenobiotic compound able to exert estrogen-like effects resulting in activation of estrogen receptor-α (ERα) followed by changed expression of its downstream target genes. In addition, studies performed over recent years suggest that DDT may also influence expression of microRNAs. However, an impact of DDT on expression of ER, microRNAs, and related target genes has not been fully elucidated. Here, using real-time PCR, we assessed changes in expression of key genes involved in hormonal carcinogenesis as well as potentially related regulatory oncogenic/tumor suppressor microRNAs and their target genes in the uterus and ovaries of female Wistar rats during single and chronic multiple-dose DDT exposure...
October 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29029336/differential-effects-of-exposure-to-single-versus-a-mixture-of-endocrine-disrupting-chemicals-on-steroidogenesis-pathway-in-mouse-testes
#7
Julio Buñay, Eduardo Larriba, Daniel Patiño-Garcia, Leonor Cruz-Fernandes, Sergio Castañeda-Zegarra, María Rodriguez-Fernandez, Jesús Del Mazo, Ricardo D Moreno
Endocrine-disrupting chemicals (EDCs) generate reproductive dysfunctions affecting the biosynthesis of steroid hormones and genes of the steroidogenic pathway. EDCs effects are mainly reported as a result of exposure to single compounds. However, humans are environmentally exposed to a mixture of EDCs. Herein, we assess chronic exposure to single alkylphenols and phthalates versus a mixture in mouse testes histology and steroidogenesis. Pregnant mice were exposed through drinking water to: 0.3 mg/Kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP), 0...
September 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28986745/nutritional-and-metabolic-stressors-on-ovine-oocyte-development-and-granulosa-cell-functions-in-vitro
#8
S Nandi, S K Tripathi, P S P Gupta, S Mondal
The present study was undertaken to study the effect of ammonia, urea, non-esterified fatty acid (NEFA), and β-hydroxybutyric acid (β-OHB) on oocyte development and granulosa cell (GC) growth parameter of ovine (Ovis aries). Ovine oocytes were matured in vitro in the presence of different concentration of ammonia, urea, NEFA, and β-OHB for 24 h, in vitro inseminated and evaluated for cleavage and blastocyst yield. Same concentrations of ammonia, urea, NEFA, and β-OHB were examined on growth parameters and hormone secretion activity of granulosa cells in vitro...
October 6, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28982933/steroidogenesis-during-postnatal-testicular-development-of-galea-spixii
#9
P R S Santos, F D Oliveira, M A M Arroyo, M F Oliveira, P Castelucci, A J Conley, A C Assis Neto
The androgen/estrogen balance is essential for normal sexual development and reproduction in mammals. Studies performed herein investigated the potential for estrogen synthesis in cells of the testes of a hystricomorph rodent, Galea spixii The study characterized the expression of the key enzymes responsible for estrogen and androgen synthesis, cytochromes P450 aromatase (P450arom), 17α-hydroxylase/17,20-lyase (P450c17) respectively, as well as the redox partner NADPH cytochrome P450 oxido-reductase (CPR) required to support electron transfer and catalysis of these P450s, by immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) analysis, throughout postnatal sexual development...
November 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28980890/macronutrient-intakes-and-serum-oestrogen-and-interaction-with-polymorphisms-in-cyp19a1-and-hsd17b1-genes-a-cross-sectional-study-in-postmenopausal-japanese-women
#10
Sahoko Takagi, Mariko Naito, Sayo Kawai, Rieko Okada, Chisato Nagata, Satoyo Hosono, Yuichiro Nishida, Naoyuki Takashima, Sadao Suzuki, Ippei Shimoshikiryo, Haruo Mikami, Hirokazu Uemura, Nagato Kuriyama, Keizo Ohnaka, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai
Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28977593/carbon-black-nanoparticles-inhibit-aromatase-expression-and-estradiol-secretion-in-human-granulosa-cells-through-the-erk1-2-pathway
#11
Violaine Simon, Charlotte Avet, Valérie Grange-Messent, Richard Wargnier, Chantal Denoyelle, Alice Pierre, Julien Dairou, Jean-Marie Dupret, Joëlle Cohen-Tannoudji
Secretion of 17-β-estradiol (E2) by human granulosa cells can be disrupted by various environmental toxicants. In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect the steroidogenic activity of cultured human granulosa cells. The human granulosa cell line KGN and granulosa cells from patients undergoing in vitro fertilization were treated with increasing concentrations of CB NPs (1 to 100 µg/mL) together or not with follicle-stimulating hormone (FSH). We observed that CB NPs are internalized in KGN cells without affecting cell viability...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28977209/the-use-of-aromatase-inhibitors-in-boys-with-short-stature-what-to-know-before-prescribing
#12
REVIEW
Alessandra Linardi, Durval Damiani, Carlos A Longui
Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to improve the predicted final height. Anastrozole (ANZ) and letrozole (LTZ) are nonsteroidal inhibitors able to bind reversibly to the heme group of cytochrome P450. In this review, we describe the pharmacokinetic profile of both drugs, discussing possible drug interactions between ANZ and LTZ with other drugs...
July 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28970799/altered-cyp19a1-and-cyp3a4-activities-due-to-mutations-a115v-t142a-q153r-and-p284l-in-the-human-p450-oxidoreductase
#13
Sameer S Udhane, Shaheena Parween, Norio Kagawa, Amit V Pandey
All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders of steroid hormone biosynthesis and affect certain drug metabolizing P450 activities. We studied mutations A115V, T142A, Q153R identified in the flavin mononucleotide (FMN) binding domain of POR that interacts with partner proteins and P284L located in the hinge region that is required for flexibility and domain movements in POR. Human wild-type (WT) and mutant POR as well as CYP3A4 and CYP19A1 proteins in recombinant form were expressed in bacteria, and purified proteins were reconstituted in liposomes for enzyme kinetic assays...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28969048/rna-seq-based-gene-expression-analysis-of-ovarian-granulosa-cells-exposed-to-zearalenone-in-vitro-significance-to-steroidogenesis
#14
Guo-Liang Zhang, Rui-Qian Zhang, Xiao-Feng Sun, Shun-Feng Cheng, Yu-Feng Wang, Chuan-Liang Ji, Yan-Zhong Feng, Jie Yu, Wei Ge, Yong Zhao, Shi-Duo Sun, Wei Shen, Lan Li
Zearalenone (ZEA) is a natural contaminant of various food and feed products representing a significant problem worldwide. Since the occurrence of ZEA in grains and feeds is frequent, the present study was carried out to evaluate the possible effects of ZEA on steroid production and gene expression of porcine granulosa cells, using RNA-seq analysis. Porcine granulosa cells were administered 10 μM and 30 μM ZEA during 72 h of culture in vitro. Following ZEA treatment the gene expression profile of control and exposed granulosa cells was compared using RNA-seq analysis...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28964809/continuous-soy-isoflavones-exposure-from-weaning-to-maturity-induces-downregulation-of-ovarian-steroidogenic-factor-1-gene-expression-and-corresponding-changes-in-dna-methylation-pattern
#15
Wenxiang Wang, Yan Sun, Yiwei Guo, Ping Cai, Yuchen Li, Jin Liu, Guoxi Cai, Aoyagi Kiyoshi, Wenchang Zhang
Female Wistar rats were treated with orally administered soy isoflavones at concentrations of 0, 25, 50, or 100mg/kg body weight from weaning until sexual maturity (3 mo.), and ovarian steroidogenesis was evaluated. After soy isoflavones were administered, a significant (P<0.05) decrease (44%) in the serum estrodial levels of the high-dose (HD) group were observed. Cultured granulosa cells from the middle- (MD) and HD groups showed significantly (P<0.05) reduced (31%, 45%, respectively) in vitro estradiol secretion, and those from the HD group showed significantly (P<0...
November 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28963671/dimorphic-expression-of-sex-related-genes-in-different-gonadal-development-stages-of-sterlet-acipenser-ruthenus-a-primitive-fish-species
#16
Wei Wang, Hua Zhu, Ying Dong, ZhaoHui Tian, Tian Dong, HongXia Hu, CuiJuan Niu
Molecular mechanism of sex determination and differentiation of sturgeon, a primitive fish species, is extraordinarily important due to the valuable caviar; however, it is still poorly known. The present work aimed to identify the major genes involved in regulating gonadal development of sterlet, a small species of sturgeon, from 13 candidate genes which have been shown to relate to gonadal differentiation and development in other teleost fish. The sex and gonadal development of sterlets were determined by histological observation and levels of sex steroids testosterone (T), 11-ketotestosterone (11-KT), and 17β-estradiol (E2) in serum...
December 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28919451/biphasic-modulation-of-neuro-and-interrenal-steroidogenesis-in-juvenile-african-sharptooth-catfish-clarias-gariepinus-exposed-to-waterborne-di-2-ethylhexyl-phthalate
#17
Augustine Arukwe, Oju R Ibor, Aina O Adeogun
Receptor (i.e. genomic) and non-receptor (or non-genomic) effects of endocrine toxicology have received limited or almost non-existent attention for tropical species and regions. In the present study, we have evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) on neuro- and interrenal steroidogenesis of the African catfish (Clarias gariepinus) using molecular, immunochemical and physiological approaches. Juvenile fish (mean weight and length: 5.6±0.6g and 8.2±1.2cm, respectively), were randomly distributed into ten 120L rectangular glass tanks containing 60L of dechlorinated tap water, at 50 fish per exposure group...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28888137/independent-self-construal-mediates-the-association-between-cyp19a1-gene-variant-and-subjective-well-being
#18
Xing Yang, Yafang Yang, Mengying Xue, Pengpeng Fang, Guomin Shen, Kejin Zhang, Xiaocai Gao, Rongjun Yu, Pingyuan Gong
Testosterone and estrogen are involved in self-related behavioral dispositions and experiences of subjective well-being. In this study, we investigated to what extent the aromatase (CYP19A1) gene, which encodes an enzyme in converting testosterone into estrogen, contributes to subjective well-being and in another self-related disposition: independent and interdependent self-construal. In study 1, a meta-analysis showed that the GG genotype of CYP19A1 (a G/A substitution at Val80, rs700518) was associated with higher testosterone and lower estradiol...
October 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28866654/hydroxylation-and-sulfation-of-sex-steroid-hormones-in-inflammatory-liver
#19
Sang R Lee, Seung-Yeon Lee, Sang-Yun Kim, Si-Yun Ryu, Bae-Kuen Park, Eui-Ju Hong
Sex steroids, also known as gonadal steroids, are oxidized with hydroxylation by cytochrome P450, glucuronidation by UDP-glucuronosyltransferase, sulfation by sulfotransferase, andO-methylation by catechol O-methyltransferase. Thus, it is important to determine the process by which inflammation influences metabolism of gonadal hormones. Therefore, we investigated the mechanism of metabolic enzymes against high physiologic inflammatory responsein vivo to study their biochemical properties in liver diseases. In this study, C57BL/6N mice were induced with hepatic inflammation by diethylnitrosamine (DEN) exposure...
September 26, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28863349/effect-of-bovine-somatotropin-injection-in-late-pregnant-holstein-heifers-on-metabolic-parameters-and-steroidogenic-potential-of-the-first-postpartum-dominant-follicle
#20
Diego Andres Velasco Acosta, Augusto Schneider, Carolina Bespalhok Jacometo, Joao Alvarado Rincon, Felipe Cardoso, Marcio Nunes Corrêa
The aim of this study was to determine the effect of pre-partum injections of bovine somatotropin (bST) in dairy heifers on metabolic markers and the steroidogenic potential of the first postpartum dominant follicle. Heifers were assigned to two groups: bST (ST; n = 29), that received two doses of bST (500 mg/dose) at -28 and -14 days relative to calving; and control (CTL; n = 30), that did not received bST. Follicular development was monitored via ultrasound every 3 days starting at 8 days in milk (DIM) in a subset of 20 heifers until the day the first large follicle reached a diameter of 16 mm...
August 26, 2017: Theriogenology
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