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https://www.readbyqxmd.com/read/28732081/il-6-variant-is-associated-with-metastasis-in-breast-cancer-patients
#1
Chike O Abana, Brian S Bingham, Ju Hwan Cho, Amy J Graves, Tatsuki Koyama, Robert T Pilarski, A Bapsi Chakravarthy, Fen Xia
INTRODUCTION: Although tumor metastases remain significant drivers of mortality, the genetic factors that increase the risks of metastases are not fully identified. Interleukin 6 (IL-6) has emerged as an important factor in breast cancer progression with IL-6 single nucleotide polymorphism (SNP) variants shown to affect survival. We hypothesized that SNPs of the IL-6 promoter at rs1800795 in breast cancer patients are associated with distant metastases. METHODS: We performed an initial case-control study using Vanderbilt University Medical Center's BioVU, a genomic biobank linked to de-identified electronic medical records in the Synthetic Derivative database, to identify germline SNPs that may predict the development of metastatic disease to any site from any solid tumor including breast cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28727931/pumping-milk-without-ever-feeding-at-the-breast-in-the-moms2moms-study
#2
Sarah A Keim, Kelly M Boone, Reena Oza-Frank, Sheela R Geraghty
BACKGROUND: More than 85% of contemporary lactating women in the United States express their milk at least sometimes. Some produce milk exclusively through pumping. We characterized women who pumped but never fed at the breast and compared their infant feeding practices with those of women who fed at the breast with or without pumping. SUBJECTS AND METHODS: Study participants were those delivered at Ohio State University Wexner Medical Center in 2011 and completed a questionnaire at 12 months postpartum (n = 478)...
July 20, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28709519/racial-discrimination-and-perinatal-sleep-quality
#3
Brittney Francis, Mark Klebanoff, Reena Oza-Frank
OBJECTIVE: This research examined the association between perceived everyday racial discrimination, as a psychosocial stressor, and perinatal sleep quality. DESIGN: Cross-sectional (N=640) and longitudinal associations (N=133) between everyday experiences of discrimination and sleep quality were examined using a pregnancy and postpartum data registry. PARTICIPANTS: We studied a sample of 640 unique women from the Perinatal Research Repository (PRR), a longitudinal study of mothers, fathers, and babies recruited from Nationwide Children's Hospital and The Ohio State University in Columbus, Ohio...
August 2017: Sleep Health
https://www.readbyqxmd.com/read/28705744/the-relationship-between-ocular-trauma-and-substance-abuse-in-emergency-department-patients
#4
Sylvia L Chang, Vaama Patel, John Giltner, Richard Lee, Catherine A Marco
INTRODUCTION: Eye injury is the second most common cause of visual impairment and a leading cause of monocular blindness in the United States. There are approximately 6 million ED visits related to drug use annually, including misuse or abuse of pharmaceuticals and illicit drug use. The purpose of this study was to assess the relationship between ocular trauma and substance abuse among emergency department patients and to assess that relationship with demographic factors, including age and gender...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28704290/developing-a-conversational-virtual-standardized-patient-to-enable-students-to-practice-history-taking-skills
#5
Kellen Maicher, Douglas Danforth, Alan Price, Laura Zimmerman, Bruce Wilcox, Beth Liston, Holly Cronau, Laurie Belknap, Cynthia Ledford, David Way, Doug Post, Allison Macerollo, Milisa Rizer
INTRODUCTION: Although traditional virtual patient simulations are designed to teach and assess clinical reasoning skills, few employ conversational dialogue with the patients. The virtual standardized patients (VSPs) described herein represent standardized patients that students interview using natural language. Students take histories and develop differential diagnoses of the VSPs as much as they would with standardized or actual patients. The student-VSP interactions are recorded, creating a comprehensive record of questions and the order in which they were asked, which can be analyzed to assess information-gathering skills...
April 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28684146/physiologically-based-pharmacokinetic-modeling-of-human-exposure-to-perfluorooctanoic-acid-suggests-historical-non-drinking-water-exposures-are-important-for-predicting-current-serum-concentrations
#6
Rachel Rogers Worley, Xiaoxia Yang, Jeffrey Fisher
Manufacturing of perfluorooctanoic acid (PFOA), a synthetic chemical with a long half-life in humans, peaked between 1970 and 2002, and has since diminished. In the United States, PFOA is detected in the blood of >99% of people tested, but serum concentrations have decreased since 1999. Much is known about exposure to PFOA in drinking water; however, the impact of non-drinking water PFOA exposure on serum PFOA concentrations is not well characterized. The objective of this research is to apply physiologically based pharmacokinetic (PBPK) modeling and Monte Carlo analysis to evaluate the impact of historic non-drinking water PFOA exposure on serum PFOA concentrations...
July 3, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28678637/transitioning-illicit-drug-preferences-and-emerging-user-identities-in-ohio-the-proliferation-of-methamphetamine-use-among-african-americans
#7
Karen Coen Flynn, Lee D Hoffer
Understanding the social dynamics of local methamphetamine markets is critical to improving community health and reducing social costs associated with illicit drug use. We examine a local drug market in Summit County, Ohio, wherein methamphetamine users ascribe themselves different ethnic identities from those long associated with the drug elsewhere in the United States. Qualitative interviews with 52 study participants demonstrate that very poor and homeless White males and females are now using methamphetamine; however, even more surprising is that 31 of the participants identified themselves as poor or homeless, male or female African, Native, biracial, or multiracial Americans...
July 5, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28668233/incidence-and-demographics-of-pediatric-intracranial-hypertension
#8
Natalie Gillson, Charlotte Jones, Rachel E Reem, David L Rogers, Nicholas Zumberge, Shawn C Aylward
OBJECTIVE: We analyzed the incidence and demographic features of pediatric intracranial hypertension. METHODS: Inpatient and outpatient encounters of children aged 18 years or younger who were diagnosed with primary (idiopathic) or secondary intracranial hypertension between January 2010 and December 2013 were identified. Data were collected from a subspecialty clinic devoted to intracranial hypertension and the sole children's hospital in a large Midwestern city of the United States...
August 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28661300/maximizing-community-voices-to-address-health-inequities-how-the-law-hinders-and-helps
#9
Julie Ralston Aoki, Christina Peters, Laura Platero, Carter Headrick
This paper highlights the need to apply an equity lens when assessing the impact of preemption and related legal doctrines on community health. Community autonomy to set and pursue public health priorities is an essential part of achieving health equity. Unfortunately, the priorities of organized industry interest groups often conflict with health equity goals. These groups have a history of successfully using law to limit community autonomy to pursue public health measures, most notably through preemption and related legal doctrines...
March 2017: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28640576/the-effect-of-aromatherapy-on-insomnia-and-other-common-symptoms-among-patients-with-acute-leukemia
#10
Lisa Blackburn, Sara Achor, Betty Allen, Nicole Bauchmire, Danielle Dunnington, Rebecca Klisovic, Steven Naber, Kirsten Roblee, Angela Samczak, Kelly Tomlinson-Pinkham, Esther Chipps
Purpose/Objectives: To determine if the use of aromatherapy improves insomnia and other common symptoms in hospitalized patients with newly diagnosed acute leukemia. Design: A randomized, crossover, washout trial. Setting: An inpatient acute leukemia unit at the Arthur G. James Cancer Hospital and Richard L. Solove Research Institute of the Wexner Medical Center at Ohio State University in Columbus. Sample: 50 patients who were newly diagnosed with acute leukemia and hospitalized to receive their initial four weeks of intensive induction chemotherapy...
June 16, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28633999/characteristics-of-a-mild-traumatic-brain-injury-sample-recruited-using-amazon-s-mechanical-turk
#11
John Bernstein, Matthew Calamia
BACKGROUND: Several barriers exist in the recruitment of individuals with a history of mild traumatic brain injury (mTBI). The current study is the first to examine whether crowdsourcing, which has been used in other clinical populations, is useful in the recruitment of those with mTBI. OBJECTIVE: To examine whether Amazon's Mechanical Turk (MTurk), an online crowdsourcing platform, is a useful tool in the recruitment of individuals with a history of mTBI and to examine the injury and psychological characteristics of individuals who report a history of mTBI...
June 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28632239/feasibility-of-mind-body-movement-programs-for-cancer-survivors
#12
Kristine K Browning, Jennifer Kue, Felisha Lyons, Janine Overcash
PURPOSE/OBJECTIVES: To evaluate mind-body movement exercise (MBME) classes (yoga, tai chi, and Qigong) for cancer survivors. 
. DESIGN: A single-group, repeated-measures design.
. SETTING: The Ohio State University Wexner Medical Center-Arthur G. James Cancer Hospital in Columbus.
. SAMPLE: 33 adult cancer survivors, with any cancer diagnosis, participating in MBME classes.
. METHODS: The researchers sought to examine feasibility of multiple data collection time points and data collection measures; acceptability; and changes to physical, emotional, and biometric measures over time, as a result of participation in MBME classes...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28624057/surveillance-strategies-in-the-follow-up-of-melanoma-patients-too-much-or-not-enough
#13
James Kurtz, Georgia M Beasley, Doreen Agnese, Kari Kendra, Thomas E Olencki, Alicia Terando, J Harrison Howard
BACKGROUND: After appropriate initial therapy for patients with stage II-III melanoma, there is no consensus regarding surveillance. Thus, follow-up is highly variable among institutions and individual providers. The National Comprehensive Cancer Network recommends routine clinical examination and consideration of imaging for stage IIB-IIIC every 3-12 mo with no distinction between stages. Detection of recurrence is important as novel systemic therapies and surgical resection of recurrence may provide survival benefits...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28616442/human-coronavirus-hku1-infection-among-adults-in-cleveland-ohio
#14
Anubhav Kanwar, Suresh Selvaraju, Frank Esper
BACKGROUND: Human coronaviruses (CoV) have been long recognized as a common cause of respiratory tract disease including severe respiratory tract illness. Coronavirus-HKU1 has been described predominantly among children less than 5 years of age in the United States with few studies characterizing the disease spectrum among adults. METHODS: Nasopharyngeal specimens of patients with respiratory symptoms were analyzed for CoV-HKU1 by NxTAG Respiratory Pathogen Panel multiplex assay from February 7, 2016 to April 30, 2016...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28611072/decoupled-leaf-and-root-carbon-economics-is-a-key-component-in-the-ecological-diversity-and-evolutionary-divergence-of-deciduous-and-evergreen-lineages-of-genus-rhododendron
#15
Juliana S Medeiros, Jean H Burns, Jaynell Nicholson, Louisa Rogers, Oscar Valverde-Barrantes
PREMISE: We explored trait-trait and trait-climate relationships for 27 Rhododendron species while accounting for phylogenetic relationships and within-species variation to investigate whether leaf and root traits are coordinated across environments and over evolutionary time, as part of a whole-plant economics spectrum. METHODS: We examined specific leaf area (SLA) and four root traits: specific root length (SRL), specific root tip abundance (SRTA), first order diameter, and link average length, for plants growing in a cold, seasonal climate (Kirtland, Ohio) and a warmer, less seasonal climate (Federal Way, Washington) in the United States...
June 13, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28610942/evaluation-of-a-pharmacist-managed-electrolyte-protocol-in-outpatients-on-antiarrhythmic-medications
#16
Victor P Long Iii, Cynthia A Carnes, Jonathan Vecchiet, Mahmoud Houmsse, Andrea Hirsch, Melissa J Snider
OBJECTIVE: To evaluate the effectiveness of a pharmacist-managed treatment protocol in achieving and maintaining serum potassium level ([K(+)]) in the desired range. SETTING: Antiarrhythmic Medications Clinic, The Ohio State University Wexner Medical Center, Columbus, Ohio, from 2009 to 2013. PRACTICE DESCRIPTION: Patients are referred for antiarrhythmic monitoring at this pharmacist-run, electrophysiologist-supervised clinic. Each visit includes medication reconciliation for drug interaction identification, patient interview for potential adverse effects or arrhythmia symptoms, patient education, and drug therapy monitoring through ordering and review of objective testing...
June 10, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28609223/the-influence-of-multiple-chemical-and-non-chemical-stressors-on-benthic-communities-in-a-mid-west-agricultural-stream
#17
Lenwood W Hall, Willian D Killen, Ronald D Anderson, Raymond W Alden
The objective of this 3-year study was to characterize benthic communities and physical habitat in an agricultural stream in the mid-west area of the United States (Big Bureau Creek, Illinois). Concurrent basic water quality parameters and seven nutrients were measured in the water column. Sediment measurements from depositional areas were conducted for bifenthrin, Total Organic Carbon, grain size, polychlorinated biphenyls (PCBs) and eight metals. All parameters were measured at 12 sites annually during the late summer for a 3-year period (2014, 2015 and 2016)...
June 13, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28602249/ten-year-survey-of-cyanobacterial-blooms-in-ohio-s-waterbodies-using-satellite-remote-sensing
#18
Tyler Gorham, Yuanyuan Jia, C K Shum, Jiyoung Lee
Cyanobacterial blooms are on the rise globally and are capable of adversely impacting human, animal, and ecosystem health. Blooms dominated by cyanobacteria species capable of toxin-production are commonly observed in eutrophic freshwater. The presence of cyanobacterial blooms in selected Ohio lakes, such as Lake Erie and Grand Lake St. Marys, has been well studied, but much less is known about the geographic distribution of these blooms across all of Ohio's waterbodies. We examined the geographic distribution of cyanobacterial blooms in Ohio's waterbodies from 2002 to 2011, using a nested semi-empirical algorithm and remotely sensed data from the Medium Resolution Imaging Spectrometer (MERIS) onboard the European Space Agency's Envisat...
June 2017: Harmful Algae
https://www.readbyqxmd.com/read/28602120/breastfeeding-support-a-geographic-perspective-on-access-and-equity
#19
Tony H Grubesic, Kelly M Durbin
BACKGROUND: Clinical lactation professionals, breastfeeding peer counseling, and mother-to-mother support are important sources of information and guidance for helping mothers initiate and maintain breastfeeding in the early weeks, months, and years postpartum. However, there is limited information concerning the geographic barriers that mothers face when seeking this support. Research aim: This study aimed to identify the geographic barriers to breastfeeding support, delineate gaps in access, assess inequities in the distribution of local support, and highlight the underlying differences in access and equity for different demographic and socioeconomic groups...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28594193/examination-of-traumatic-brain-injury-exposure-among-veterans-with-spinal-cord-injury
#20
Maggi A Budd, Thomas M Dixon, Scott D Barnett, Eni Njoh, Lance L Goetz, Lisa Ottomanelli
OBJECTIVE: The authors investigated lifetime exposure to traumatic brain injury (TBI) among veterans with spinal cord injury (SCI) in order to describe outcome differences as a function of self-reported TBI history. DESIGN: Cross sectional study, veterans with SCI (N = 857) completed the Ohio State University TBI Identification interview method (OSU-TBI); Veterans RAND 36-Item Health Survey (VR-36); Quick Inventory for Depressive Symptomatology, Self-Report (QIDS-SR); Patient Health Questionnaire-9; Satisfaction with Life Scale; Craig Handicap Assessment and Reporting Technique (CHART; along with clinician-rated Functional Independence Measure (FIM) Total, Motor, and Cognitive scores...
June 8, 2017: Rehabilitation Psychology
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