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https://www.readbyqxmd.com/read/29032804/-clinical-relevance-of-esr1-circulating-mutations-detection-in-hormone-receptor-positive-metastatic-breast-cancer
#1
REVIEW
Florian Clatot, Anne Perdrix, David Sefrioui, Nasrin Sarafan-Vasseur, Frédéric Di Fiore
If hormone therapy is a key treatment for hormone receptor positive advanced breast cancers, secondary resistance occurs as a rule. Recently, acquired alterations of the ESR1 gene have been identified as a mechanism of resistance on aromatase inhibitor (AI) treatment. The selective pressure by AI exposure during the metastatic setting triggers the emergence of ESR1 activating mutations. In that context, the "liquid biopsy" concept has been used to detect this molecular resistance before progression. Thus, the ESR1 circulating mutation detection will soon be used in daily practice to help monitoring patients on AI treatment and provide an early change for specific therapies that still have to be determined in prospective clinical trials...
October 9, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#2
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29032291/impact-of-an-osteoporosis-specialized-unit-on-bone-health-in-breast-cancer-survivals-treated-with-aromatase-inhibitors
#3
Purificación Martínez, Elena Galve, Virginia Arrazubi, M Ángeles Sala, Seila Fernández, Clara E Pérez, Juan F Arango, Iñaki Torre
OBJECTIVE: Considering the increased fracture risk in early breast cancer patients treated with aromatase inhibitors (AI), we assessed the impact of a preventive intervention conducted by a specialized osteoporosis unit on bone health at AI treatment start. MATERIAL AND METHODS: Retrospective cohort of postmenopausal women who started treatment with AI after breast cancer surgical/chemotherapy treatment and were referred to the osteoporosis unit for a comprehensive assessment of bone health...
October 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29032032/enzyme-inhibitory-activities-an-insight-into-the-structure-activity-relationship-of-biscoumarin-derivatives
#4
Muhammad Faisal, Aamer Saeed, Danish Shahzad, Tanzeela Abdul Fattah, Bhajan Lal, Pervaiz Ali Channar, Jamaluddin Mahar, Shomaila Saeed, Parvez Ali Mahesar, Fayaz Ali Larik
Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occurred in the bioactive metabolites of marine and terrestrial organisms. On account of pharmacological and biological applications, biscoumarins have long been the subject of innumerable enzyme inhibition studies. In this review the pros and cons of enzyme inhibition studies of biscoumarins as urease inhibitors, aromatase inhibitors, NPPs, α-glucosidase inhibitors, α-amylase inhibitors, HIV-1 integrase inhibition, steroid sulfatase inhibitors and c-Met inhibitors are discussed in a systematic way...
October 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031778/extended-adjuvant-aromatase-inhibition-after-sequential-endocrine-therapy-data-a-randomised-phase-3-trial
#5
Vivianne C G Tjan-Heijnen, Irene E G van Hellemond, Petronella G M Peer, Astrid C P Swinkels, Carolien H Smorenburg, Maurice J C van der Sangen, Judith R Kroep, Hiltje De Graaf, Aafke H Honkoop, Frans L G Erdkamp, Franchette W P J van den Berkmortel, Maaike de Boer, Wilfred K de Roos, Sabine C Linn, Alexander L T Imholz, Caroline M Seynaeve
BACKGROUND: The effect of extended adjuvant aromatase inhibition in hormone receptor-positive breast cancer after sequential endocrine therapy of tamoxifen followed by an aromatase inhibitor for a 5-year treatment period still needs clarification. To address this issue, we began the DATA study to assess different durations of anastrozole therapy after tamoxifen. METHODS: DATA was a prospective, randomised, open-label, multicentre, phase 3 study done in 79 hospitals in the Netherlands...
October 11, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29031477/acute-developmental-exposure-to-4-hydroxyandrostenedione-has-a-long-term-effect-on-visually-guided-behaviors
#6
Cassie J Gould, Jenna L Wiegand, Victoria P Connaughton
Estrogenic and anti-estrogenic endocrine disrupting compounds (EDCs) are recognized as critical modulators of neural development, including sensory system development. Using the zebrafish model, we tested the effect of transient developmental exposure to a known anti-estrogenic EDC on adult visually-guided behavior. In particular, we exposed zebrafish aged 24-hour post-fertilization (hpf), 72 hpf, or 7-days post-fertilization (dpf) to the aromatase inhibitor 4-hydroxyandrostenedione (4-OH-A) for 24h. After this time, the fish were removed from treatment, placed into control conditions, and reared until adulthood (3-4months) when visually-guided optomotor responses (OMR) were assessed...
October 11, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29017436/role-of-markov-modeling-approaches-to-understand-the-impact-of-infertility-treatments
#7
Arni S R Srinivasa Rao, Michael P Diamond
We are proposing to use Markov modeling type of analysis to understand data generated by treatments for infertility in women receiving ovarian stimulations. We describe the conceptual novelties, need for such an analysis, basics of the proposed methods, and theoretical constructions of various probabilities associated with practical level implementation of the Markov modeling procedures. This method can be adopted to infertility-related data visualizations whenever progression of outcome stages in infertility treatment is recorded...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29016690/expression-profile-of-amh-amh-during-bi-directional-sex-change-in-the-protogynous-orange-spotted-grouper-epinephelus-coioides
#8
Guan-Chung Wu, Hau-Wen Li, Wei-Guan Tey, Chien-Ju Lin, Ching-Fong Chang
Gonadal differentiation is tightly regulated by the initial sex determining gene and the downstream sex-related genes in vertebrates. However, sex change in fish can alter the sexual fate from one sex to the other. Chemical-induced maleness in the protogynous orange-spotted grouper is transient, and a reversible sex change occurs after the chemical treatment is withdrawn. We used these characteristics to study Amh signaling during bi-directional sex change in the grouper. We successfully induced the female-to-male sex change by chemical (aromatase inhibitor, AI, or methyltestosterone, MT) treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28992264/proteasome-26s-subunit-psmd1-regulates-breast-cancer-cell-growth-through-p53-protein-degradation
#9
Toshiyuki Okumura, Kazuhiro Ikeda, Takafumi Ujihira, Koji Okamoto, Kuniko Horie-Inoue, Satoru Takeda, Satoshi Inoue
Endocrine therapy using antiestrogens and aromatase inhibitors is usually efficient to treat patients with hormone-sensitive breast cancer. Many patients with endocrine therapy, however, often acquire resistance. In the present study, we performed functional screening using short hairpin RNA library to dissect genes involved in antiestrogen tamoxifen resistance in MCF-7 breast cancer cells. We identified seven candidate genes that are associated with poor prognosis of breast cancer patients based on clinical dataset...
August 3, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28984380/knotting-nets-molecular-junctions-of-interconnecting-endocrine-axes-identified-by-application-of-the-adverse-outcome-pathway-aop-concept
#10
REVIEW
Maria Brüggemann, Oliver Licht, Éva Fetter, Matthias Teigeler, Christoph Schäfers, Elke Eilebrecht
In order to be defined as endocrine disruptor, a substance has to meet several criteria, including the induction of specific adverse effects, specific endocrine mode-of-action and a plausible link between both. Especially the latter criterion might not always be unequivocally determined, particularly as the endocrine system consists of diverse endocrine axes. The axes closely interact with each other, and manipulation of one triggers effects on the other. This review aimed at identifying some of the many interconnections between these axes...
October 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28983985/zenk-induction-in-the-zebra-finch-brain-by-song-relationship-to-hemisphere-rhythm-estradiol-and-sex
#11
Jennifer Lampen, Devin J McAuley, Soo-Eun Chang, Juli Wade
Estradiol is abundant in the zebra finch auditory forebrain and has the capacity to modulate neural responses to auditory stimuli with specificity due to both hemisphere and sex. Arrhythmic song induces greater ZENK expression than rhythmic song in the caudomedial nidopallium (NCM), caudomedial mesopallium (CMM), and nucleus taeniae (Tn) of adult zebra finches. The increases in the auditory regions, NCM and CMM, may result from detection of errors in the arrhythmic song relative to the learned template. In the present study, zebra finches were treated with estradiol, the aromatase inhibitor fadrozole, or a control, and exposed to rhythmic or arrhythmic song to assess the effect of estradiol availability on neural responses to auditory rhythms...
October 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28980224/circulating-micrornas-in-patients-with-hormone-receptor-positive-metastatic-breast-cancer-treated-with-dovitinib
#12
Narayan Shivapurkar, Eveline E Vietsch, Erin Carney, Claudine Isaacs, Anton Wellstein
BACKGROUND: Serial analysis of biomarkers in the circulation of patients undergoing treatment ("liquid biopsies") can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic acids such as microRNAs (miRs) can reveal altered expression patterns indicative of mechanism of drug action, cancer growth, and tumor-stroma interactions. RESULTS: Here we analyzed plasma miRs in patients with hormone receptor positive, metastatic breast cancer with prior disease progression during aromatase inhibitor therapy (n = 8) in a phase I/II trial with the multiple tyrosine kinase inhibitor dovitinib (TKI258)...
October 4, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28977209/the-use-of-aromatase-inhibitors-in-boys-with-short-stature-what-to-know-before-prescribing
#13
REVIEW
Alessandra Linardi, Durval Damiani, Carlos A Longui
Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to improve the predicted final height. Anastrozole (ANZ) and letrozole (LTZ) are nonsteroidal inhibitors able to bind reversibly to the heme group of cytochrome P450. In this review, we describe the pharmacokinetic profile of both drugs, discussing possible drug interactions between ANZ and LTZ with other drugs...
July 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28975114/activation-of-phosphoinositide-3-kinase-akt-mechanistic-target-of-rapamycin-pathway-and-response-to-everolimus-in-endocrine-receptor-positive-metastatic-breast-cancer-a-retrospective-pilot-analysis-and-viewpoint
#14
Jyoti Bajpai, Anant Ramaswamy, Arun Chandrasekharan, Surya Mishra, Tanuja Shet, Sudeep Gupta, R A Badwe
INTRODUCTION: Biomarkers predictive of response to mechanistic target of rapamycin (mTOR) inhibitor, everolimus, in endocrine receptor (ER)-positive metastatic breast cancer (MBC) are a work in progress. We evaluated the feasibility of directly measuring mTOR activity and phosphatase and tensin homolog (PTEN) expression and correlating their expression with response and survival. MATERIALS AND METHODS: MBC patients who received everolimus with endocrine therapy (ET) after progression on an aromatase inhibitor and had adequate tissue preservation for estimation of mTOR activity and PTEN expression were selected for analysis from a prospectively maintained database...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28973704/neoadjuvant-and-adjuvant-therapies-for-breast-cancer
#15
REVIEW
Susmitha Apuri
Breast cancer remains the most common cancer in women in the United States, the second most common cause of cancer death, and the main cause of death in women ages 45 to 55 years. Molecular analyses have shown that breast cancer is divided into several subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] enriched, and basal-like), based on microarray techniques. Patients diagnosed as having breast cancer may undergo adjuvant or neoadjuvant chemotherapy, depending on the tumor size, hormone receptor, HER2/neu status, and desire for breast preservation...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28971776/recent-progress-of-novel-steroid-derivatives-and-their-potential-biological-properties
#16
Shaoyong Ke
Steroid and its derivatives have been proved to have important and diverse biological functions, which present the wide spectrum of biological activities such as antitumor, antiviral, antibacterial, antimicrobial, antifungal, antioxidant, insecticidal, aromatase inhibitors, 5α-reductase inhibitors and neuromuscular blocking agents et c. Versatile features of steroid-derived compounds have emerged, so the aim of the present paper was to review the recent advances of steroid-based derivatives mainly focused on their structures and biological properties...
October 3, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28971759/steroidal-oximes-useful-compounds-with-antitumor-activities
#17
Catarina Canário, Samuel Silvestre, Amílcar Falcão, Gilberto Alves
BACKGROUND: Steroids play an important role in life because they can regulate a variety of biological processes and have been widely used in medicine namely as anti-inflammatory, anabolic, contraceptives and anticancer drugs. In recent years, there has been an increasing interest in the introduction of the oxime group in a large variety of molecules in order to increase their biological effects. This review highlights steroidal oximes with anticancer properties and their potential mechanisms of action, as well as data on their relative potencies reported in literature in the last few years...
October 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28969562/ovarian-stimulation-in-poor-responders-have-we-made-progress
#18
Robert Roman, Naiha Mussarat, Laura Detti
BACKGROUND: Poor ovarian responders (POR) pose a challenge to a physicians' ability to choose a stimulation protocol that maximizes the number of oocytes harvested and their chances of conception with multiple protocols aimed at improving pregnancy rates in this poor prognosis population. The Bologna criteria standardized the diagnosis of POR and allows for a more homogenous patient population in clinical trials. METHODS: A structured review of the literature, which encompasses research on Bologna-defined POR, identified several proposed protocols to optimize pregnancy rates in poor responders...
October 2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28969348/grip-strength-in-women-being-treated-for-breast-cancer-and-receiving-adjuvant-endocrine-therapy-systematic-review
#19
REVIEW
E M Van der Weijden-Van Doornik, Dagmar E Slot, Chris Burtin, G A van der Weijden
Background: Adjuvant endocrine therapy in breast cancer has increased survival rates; however, it is not without musculoskeletal side effects. Purpose: The purpose of this review was to systematically and critically appraise the available scientific evidence concerning the effect of adjuvant endocrine treatment on grip strength in women being treated for breast cancer. Data sources and study selection: The National Library of Medicine (MEDLINE-PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), Excerpta Medical Database by Elsevier (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Physiotherapy Evidence Database (PEDro) were searched from inception to February 2017 for appropriate papers that could answer the focused question...
September 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28968163/monarch-3-abemaciclib-as-initial-therapy-for-advanced-breast-cancer
#20
Matthew P Goetz, Masakazu Toi, Mario Campone, Joohyuk Sohn, Shani Paluch-Shimon, Jens Huober, In Hae Park, Olivier Trédan, Shin-Cheh Chen, Luis Manso, Orit C Freedman, Georgina Garnica Jaliffe, Tammy Forrester, Martin Frenzel, Susana Barriga, Ian C Smith, Nawel Bourayou, Angelo Di Leo
Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as monotherapy and in combination with fulvestrant in women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer previously treated with endocrine therapy. Methods MONARCH 3 is a double-blind, randomized phase III study of abemaciclib or placebo plus a nonsteroidal aromatase inhibitor in 493 postmenopausal women with HR-positive, HER2-negative advanced breast cancer who had no prior systemic therapy in the advanced setting...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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