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https://www.readbyqxmd.com/read/27933364/behavioral-alterations-of-zebrafish-larvae-after-early-embryonic-exposure-to-ketamine
#1
Luís M Félix, Luís M Antunes, Ana M Coimbra, Ana M Valentim
RATIONALE: Ketamine has been associated with pediatric risks that include neurocognitive impairment and long-term behavioral disorders. However, the neurobehavioral effects of ketamine exposure in early development remain uncertain. OBJECTIVES: This study aimed to test stage- and dose-dependent effects of ketamine exposure on certain brain functions by evaluating alterations in locomotion, anxiety-like and avoidance behaviors, as well as socialization. METHODS: Embryos were exposed to different concentrations of ketamine (0, 0...
December 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27933002/gender-differences-in-demographic-and-clinical-features-of-physicians-admitted-to-a-program-for-medical-professionals-with-mental-disorders
#2
María Dolores Braquehais, Pilar Arrizabalaga, Pilar Lusilla, Sergi Valero, Miquel Jordi Bel, Eugeni Bruguera, Leo Sher, Miquel Casas
OBJECTIVE: To examine the demographic and clinical differences between men and women admitted to a Physicians' Health Programme (PHP). METHOD: Retrospective chart review of 778 medical records of physicians admitted to the Barcelona PHP from February 1, 1998 until December 31, 2015. RESULTS: Women admitted to the Barcelona PHP were younger than men, were more likely to be self-referred and to be admitted for a non-addictive mental disorder...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27932983/cannabidiol-regulation-of-learned-fear-implications-for-treating-anxiety-related-disorders
#3
Regimantas Jurkus, Harriet L L Day, Francisco S Guimarães, Jonathan L C Lee, Leandro J Bertoglio, Carl W Stevenson
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effects of psychological treatments such as exposure therapy are often only temporary and medications can be ineffective and have adverse side effects. Growing evidence from human and animal studies indicates that cannabidiol, the main non-psychotomimetic phytocannabinoid present in Cannabis sativa, alleviates anxiety in paradigms assessing innate fear...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932864/efficacy-and-tolerability-of-vilazodone-for-major-depressive-disorder-evidence-from-phase-iii-iv-randomized-controlled-trials
#4
Ligen Shi, Jingyi Wang, Shenbin Xu, Yunrong Lu
Vilazodone is a new molecule approved for major depressive disorder (MDD). This report focuses on the efficacy and tolerability of vilazodone for MDD. MEDLINE, EMBASE, and Cochrane Library were searched. A total of 1,930 patients from four trials were included. A significant improvement in the Montgomery-Asberg Depression Rating Scale (MADRS) total score was seen as early as week 2 (P<0.01) in vilazodone-treated patients. The results showed a higher rate of MADRS response with vilazodone compared with placebo (P<0...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932627/next-steps-toward-understanding-the-relationship-between-cigarette-smoking-and-depression-anxiety-disorders-a-lifecourse-perspective
#5
EDITORIAL
Renee D Goodwin
No abstract text is available yet for this article.
December 7, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27931891/a-systematic-review-of-anxiety-prevalence-in-adults-within-primary-care-and-community-settings-in-malaysia
#6
Chin Hoong Wong, Zia U Bakt Sultan Shah, Cheong Lieng Teng, Tzi Quen Lin, Zainab Abdul Majeed, Chun Wai Chan
BACKGROUND: Anxiety disorders are common mental health disorders with significant impact on the individual as well as burden on the country as a whole. METHODS: A systematic review of databases, reference lists, internet sources, and input from content experts revealed 42 studies that documented the prevalence of anxiety symptoms or disorders. 12 of these studies specifically evaluated anxiety disorders. RESULTS: 4 studies looked at the prevalence of anxiety disorders in the general population, whilst the remainder focused on selected population groups: university students (4 studies); substance abuse (3 studies); and victims of abuse (1 study)...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931890/inpatients-with-major-depressive-disorder-psychometric-properties-of-the-new-multidimensional-depression-scale
#7
Mohammad Darharaj, Mojtaba Habibi, Michael J Power, Farzaneh Farzadian, Maesoumeh Rahimi, Habibeh Kholghi, Maryam Kazemitabar
The New Multi-dimensional Depression Scale (NMDS) is one of the most comprehensive scales that measures depression symptoms in four domains, including emotional, cognitive, somatic, and interpersonal. This study aimed to evaluate the factor structure and psychometric properties of the NMDS in a group of Iranian inpatients with Major Depressive Disorder (MDD). At first, the scale was translated into Persian and used as part of a battery consisting of the Beck Depression Inventory-II (BDI-II), Oxford Happiness Inventory (OHI), Beck Anxiety Inventory (BAI), and Short Form Health Survey (SF-36)...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931887/medial-prefrontal-cortex-stimulation-accelerates-therapy-response-of-exposure-therapy-in-acrophobia
#8
Martin J Herrmann, Andrea Katzorke, Yasmin Busch, Daniel Gromer, Thomas Polak, Paul Pauli, Jürgen Deckert
BACKGROUND: Animal as well as human research indicated that the ventral medial prefrontal cortex (vmPFC) is highly relevant for fear extinction learning. Recently, we showed that targeting the vmPFC with high-frequency repetitive transcranial magnetic stimulation (rTMS) in a placebo-controlled study with 45 healthy controls induced higher prefrontal activity during extinction of conditioned stimuli (CS+) in the active compared to the sham stimulated group and better extinction learning as indicated by ratings, fear potentiated startles and skin conductance responses...
November 14, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27930990/cigarette-smoke-and-related-risk-factors-in-neurological-disorders-an-update
#9
REVIEW
Smilin Bell Aseervatham G, Sangdun Choi, Jayalakshmi Krishnan, Ruckmani K
Cigarette smoking is known to be harmful to health, and is considered the main cause of death worldwide, especially in India. Among the well-distinguished diseases related to smoking are, chronic obstructive pulmonary disease, oral and peripheral cancers, and cardiovascular complications. However, the impact of cigarette smoking on neurocognitive and neuropathological effects, including anxiety, Alzheimer's disease, Parkinson's disease, ischemic stroke, and blood-brain barrier dysfunction, still remains unclear...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930953/adolescent-binge-alcohol-exposure-increases-risk-assessment-behaviors-in-male-wistar-rats-after-exposure-to-an-acute-psychological-stressor-in-adulthood
#10
Audrey Torcaso, AnnaDorothea Asimes, Margaret Meagher, Toni R Pak
Teenage binge drinking is a common practice that has been shown to increase the risk for developing mood disorders in adulthood. The hypothalamo-pituitary-adrenal (HPA) axis is often dysfunctional in mood disorder patients, and animal models of adolescent binge alcohol exposure similarly show disordered HPA axis function, even after long periods of alcohol abstinence. Here, we sought to investigate the anxiety-like behavioral consequences of binge alcohol exposure in a Wistar rat model. Male rats were administered alcohol in a binge pattern during peri-puberty, and one month later, anxiety-like behaviors were measured using the elevated plus maze...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27930951/symptom-correspondence-between-clinicians-and-patients-on-the-yale-brown-obsessive-compulsive-scale
#11
Eric A Storch, Joshua M Nadeau, Alessandro S De Nadai, Sandra L Cepeda, Bradley C Riemann, Philip Seibell, Brian Kay
The present study examined concordance between the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and its self-report version (Y-BOCS-SR), as well as theoretically derived moderators. Sixty-seven adults (ages 18-67) with obsessive-compulsive disorder (OCD) were administered the Y-BOCS prior to completing self-report measures. The Y-BOCS-SR generated lower scores relative to the clinician-administered Y-BOCS (5.3 points lower). Strong correspondence was shown between the Y-BOCS and Y-BOCS-SR; however, many items exhibited fair to moderate agreement, particularly the resistance and control against obsessions/compulsions items...
November 30, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27930939/guided-parent-delivered-cognitive-behavioral-therapy-for-childhood-anxiety-predictors-of-treatment-response
#12
Kerstin Thirlwall, Peter Cooper, Cathy Creswell
BACKGROUND: Guided Parent-delivered Cognitive Behaviour Therapy (GPD-CBT) is a brief, effective treatment for childhood anxiety disorders, however not all children respond favourably. AIMS: To examine predictors of response to GPD-CBT. METHODS: Parents of 125 children (7-12 years) with an anxiety disorder received GPD-CBT over 2.6 or 5.3h. Recovery was measured post treatment and six months later. RESULTS: Younger children and those with primary Generalised Anxiety Disorder (GAD) improved more post treatment, but older children and those without primary GAD had better outcomes at six month follow up...
November 10, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27930513/percutaneous-trigeminal-ganglion-radiofrequency-thermocoagulation-alleviates-anxiety-and-depression-disorders-in-patients-with-classic-trigeminal-neuralgia-a-cohort-study
#13
YuanZhang Tang, Ling Ma, Na Li, Yuna Guo, Liqiang Yang, Baishan Wu, Jianning Yue, Qi Wang, Jingjie Liu, Jia-Xiang Ni
Trigeminal neuralgia (TN) is a neurological condition that presents as excruciating facial pain. Depression and anxiety are commonly associated with TN; however, anxiety and depression disorders in patients with TN and the effects of the various therapeutic strategies for TN on these disorders are not well studied.To evaluate depression and anxiety in patients with trigeminal neuralgia (TN), identify factors that predict their occurrence and study the effect of the percutaneous trigeminal ganglion radiofrequency thermocoagulation (PRT) procedure for alleviating pain on depression and anxiety...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929608/an-open-trial-of-mindfulness-based-stress-reduction-for-young-adults-with%C3%A2-social-anxiety-disorder
#14
Aslak Hjeltnes, Helge Molde, Elisabeth Schanche, Jon Vøllestad, Julie Lillebostad Svendsen, Christian Moltu, Per-Einar Binder
The present study investigated mindfulness-based stress reduction (MBSR) for young adults with a social anxiety disorder (SAD) in an open trial. Fifty-three young adults in a higher education setting underwent a standard eight-week MBSR program. Eight participants (15%) did not complete the program. Participants reported significant reductions in SAD symptoms and global psychological distress, as well as increases in mindfulness, self-compassion, and self-esteem. Using intention-to-treat (ITT) analyses, effect sizes ranged from large to moderate for SAD symptoms (Cohen's d = 0...
December 8, 2016: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/27929311/different-types-of-combat-experiences-and-associated-symptoms-in-oef-and-oif-national-guard-and-reserve-veterans
#15
M Tracie Shea, Candice Presseau, Shauna L Finley, Madhavi K Reddy, Christopher Spofford
OBJECTIVE: It is well established that exposure to combat is a risk factor for posttraumatic stress disorder (PTSD). The experiences of military personnel serving in combat zones vary widely however, leading to increased attention to the impact of different types of combat trauma. The present study examined the relationships among 3 conceptually based categories of combat exposure with 4 PTSD symptom clusters (reexperiencing, avoidance, numbing, and hyperarousal) and symptoms of guilt, depression, and anxiety...
December 8, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27928978/oxidative-stress-in-major-depressive-and-anxiety-disorders-and-the-association-with-antidepressant-use-results-from-a-large-adult-cohort
#16
C N Black, M Bot, P G Scheffer, B W J H Penninx
BACKGROUND: Oxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD) and anxiety disorders and may be influenced by antidepressant use. This study investigated the association of oxidative stress, measured by plasma levels of F2-isoprostanes and 8-hydroxy-2'-deoxyguanosine (8-OHdG) reflecting oxidative lipid and DNA damage respectively, with MDD, anxiety disorders and antidepressant use in a large cohort. METHOD: Data was derived from the Netherlands Study of Depression and Anxiety including patients with current (N = 1619) or remitted (N = 610) MDD and/or anxiety disorder(s) (of which N = 704 antidepressant users) and 612 controls...
December 8, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27928696/affective-disorders-and-health-related-quality-of-life-hrqol-in-adolescents-and-young-adults-with-multiple-sclerosis-ms-the-moderating-role-of-resilience
#17
Nunzia Rainone, Alessandro Chiodi, Roberta Lanzillo, Valeria Magri, Anna Napolitano, Vincenzo Brescia Morra, Paolo Valerio, Maria Francesca Freda
PURPOSE: To investigate the moderating role of resilience in the relationship between affective disorders and Health-Related Quality of Life (HRQoL) for adolescents and young adults with multiple sclerosis (MS). METHODS: A quantitative methodology was adopted. Fifty-three adolescents and young adults were interviewed to assess resilience as a personality trait (Ego-Resiliency Scale) and resilience as an interactive competence (CYRM-28), Health-Related Quality of Life (PedsQL 4...
December 7, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27928477/health-related-quality-of-life-and-health-utility-values-in-beta-thalassemia-major-patients-receiving-different-types-of-iron-chelators-in-iran
#18
Meysam Seyedifar, Farid Abedin Dorkoosh, Amir Ali Hamidieh, Majid Naderi, Hossein Karami, Mehran Karimi, Masoomeh Fadaiyrayeny, Masoumeh Musavi, Sanaz Safaei, Mohammad Mahdi Ahmadian-Attari, Molouk Hadjibabaie, Abdol Majid Cheraghali, Ali Akbari Sari
Background: Thalassemia is a chronic, inherited blood disorder, which in its most severe form, causes life-threatening anemia. Thalassemia patients not only engage with difficulties of blood transfusion and iron chelating therapy but also have some social challenges and health threatening factors. There are some reports on quality of life in thalassemia patients around the world from southeast of Asia to Italy in Europe and United States. In this study, we tried to evaluate and compare Health Related Quality of life (HRQoL) and the health utility in beta thalassemia major patients receiving different types of iron chelators and living in different socio-economical situations...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27928252/effects-of-passion-flower-extract-as-an-add-on-treatment-to-sertraline-on-reaction-time-in-patients-%C3%A2-with-generalized-anxiety-disorder-a-double-blind-placebo-controlled-study
#19
Mandana Nojoumi, Padideh Ghaeli, Samrand Salimi, Ali Sharifi, Firoozeh Raisi
Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software...
July 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/27928245/%C3%A2-anxiety-sensitivity-dimensions-and-generalized-anxiety%C3%A2-%C3%A2-severity-the-%C3%A2-mediating-role-of-experiential-avoidance-and-repetitive%C3%A2-%C3%A2-negative-thinking%C3%A2-%C3%A2
#20
Parvaneh Mohammadkhani, Abbas Pourshahbaz, Maryam Kami, Mahdi Mazidi, Imaneh Abasi
Objective: Generalized anxiety disorder is one of the most common anxiety disorders in the general ‎population. Several studies suggest that anxiety sensitivity is a vulnerability factor in generalized ‎anxiety severity. However, some other studies suggest that negative repetitive thinking and ‎experiential avoidance as response factors can explain this relationship. Therefore, this study ‎aimed to investigate the mediating role of experiential avoidance and negative repetitive thinking ‎in the relationship between anxiety sensitivity and generalized anxiety severity...
July 2016: Iranian Journal of Psychiatry
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