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Crohn' disease

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https://www.readbyqxmd.com/read/29912762/oral-and-otorhinolaryngological-findings-in-adults-who-were-diagnosed-with-pediatric-onset-crohn-s-disease-a-controlled-study
#1
Anu Haaramo, Heikki Alapulli, Liisa Aine, Jetta Tuokkola, Ulla Saarnisto, Risto P Roine, Anne Pitkäranta, Kaija-Leena Kolho
BACKGROUND: Up to 50% of pediatric patients with Crohn's disease (CD) report oral manifestations, but less is known about their oral health when they become adults. GOALS: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls. STUDY: Adult patients diagnosed with CD in childhood at the Children's Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912413/higher-postinduction-infliximab-serum-trough-levels-are-associated-with-healing-of-fistulizing-perianal-crohn-s-disease-in-children
#2
Wael El-Matary, Thomas D Walters, Hien Q Huynh, Jennifer deBruyn, David R Mack, Kevan Jacobson, Mary E Sherlock, Peter Church, Eytan Wine, Matthew W Carroll, Eric I Benchimol, Sally Lawrence, Anne M Griffiths
Background: There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24. Methods: In a multicenter inception cohort study, consecutive children younger than age 17 years with fistulizing perianal CD treated with IFX between April 2014 and June 2017 who had serum trough IFX titers measured before the fourth infusion were included...
June 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29912405/alphae-integrin-expression-is-increased-in-the-ileum-relative-to-the-colon-and-unaffected-by-inflammation
#3
Ryan Ichikawa, Christopher A Lamb, Jeff Eastham-Anderson, Alexis Scherl, Laura Raffals, William A Faubion, Miriam R Bennett, Anna K Long, John C Mansfield, John A Kirby, Mary E Keir
Background: Recent findings suggest that αE expression is enriched on effector T cells and that intestinal αE+ T cells have increased expression of inflammatory cytokines. αE integrin expression is a potential predictive biomarker for response to etrolizumab, a monoclonal antibody against β7 integrin that targets both α4β7 and αEβ7. We evaluated the prevalence and localisation of αE+ cells as well as total αE gene expression in healthy subjects and inflammatory bowel disease patients...
June 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29912382/postoperative-interleukin-6-predicts-intra-abdominal-septic-complications-at-an-early-stage-after-elective-intestinal-operation-for-crohn-s-disease-patients
#4
Tingbin Xie, Chenyan Zhao, Chao Ding, Liang Zhang, Minhua Cheng, Cao Chun, Wenkui Yu, Jianfeng Gong, Weiming Zhu
Background: The role of interleukin-6 (IL-6) in the prediction of intra-abdominal septic complications (IASCs) in patients with Crohn's disease (CD) remains unclear. We assessed the serum IL-6 time course and its association with postoperative IASCs in patients undergoing elective intestinal operations for CD. Methods: In total, 118 patients who underwent intestinal operations for CD were prospectively evaluated. They were divided into an IASC group and non-IASC group...
June 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29912317/microrna-590-5p-inhibits-intestinal-inflammation-by-targeting-yap
#5
Minhao Yu, Yang Luo, Zhijie Cong, Yifei Mu, Yier Qiu, Ming Zhong
Background/Aims: Hippo signaling is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, survival, apoptosis, and stem cell self-renewal. In addition, Hippo signaling is profoundly implicated in intestinal regeneration and cancer. However, its roles in the pathogenesis of Crohn's disease (CD) remain largely unexplored. Methods: Quantitative real-time PCR was performed to identify the deregulated molecules in Hippo signaling...
April 18, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29911450/inflammatory-bowel-disease-new-therapies-from-antisense-oligonucleotides
#6
Irene Marafini, Giovanni Monteleone
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal manifestations. The cause of IBD remains unknown but accumulating evidence indicates that both CD and UC arise in genetically-predisposed individuals as a result of the action of multiple environmental factors, which ultimately trigger excessive and poorly-controlled immune response against antigens of the luminal flora...
June 16, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29911021/-mycobacterium-avium-subspecies-paratuberculosis-a-possible-causative-agent-in-human-morbidity-and-risk-to-public-health-safety
#7
REVIEW
Mary Garvey
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. Infection with this microorganism results in substantial farming economic losses and animal morbidity. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29910803/expression-of-programmed-death-ligand-1-by-human-colonic-cd90-stromal-cells-differs-between-ulcerative-colitis-and-crohn-s-disease-and-determines-their-capacity-to-suppress-th1-cells
#8
Ellen J Beswick, Carl Grim, Abinav Singh, Jose E Aguirre, Marissa Tafoya, Suimin Qiu, Gerhard Rogler, Rohini McKee, Von Samedi, Thomas Y Ma, Victor E Reyes, Don W Powell, Irina V Pinchuk
Background and Aims: The role of programmed cell death protein 1 (PD-1) and its ligands in the dysregulation of T helper immune responses observed in the inflammatory bowel disease (IBD) is unclear. Recently, a novel concept emerged that CD90+ colonic (myo)fibroblasts (CMFs), also known as stromal cells, act as immunosuppressors, and are among the key regulators of acute and chronic inflammation. The objective of this study was to determine if the level of the PD-1 ligands is changed in the IBD inflamed colonic mucosa and to test the hypothesis that changes in IBD-CMF-mediated PD-1 ligand-linked immunosuppression is a mechanism promoting the dysregulation of Th1 cell responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909694/crucial-genes-of-inflammatory-bowel-diseases-explored-by-gene-expression-profiling-analysis
#9
Dehong Xie, Yudong Zhang, Hao Qu
OBJECTIVES: This study aimed to uncover new potential genes associated with the inflammatory bowel diseases (IBDs). MATERIALS AND METHODS: The datasets GSE36807 and GSE9686 were obtained from Gene Expression Omnibus (GEO). Totally, 24 Crohn's disease (CD) samples, 20 ulcerative colitis (UC) samples and 15 healthy controls in the two datasets were used for our analysis. The differentially expressed genes (DEGs) were identified by limma package. Then, co-expression network was constructed by weighted gene correlation network analysis (WGCNA) package, and co-expression network modules were obtained via clustering method...
June 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909470/risk-of-fracture-and-low-bone-mineral-density-in-adults-with-inflammatory-bowel-diseases-a-systematic-literature-review-with-meta-analysis
#10
REVIEW
P Szafors, H Che, T Barnetche, J Morel, C Gaujoux-Viala, B Combe, C Lukas
Inflammatory bowel diseases (IBDs) are associated with a decreased bone mineral density, but the impact on fractures is unknown. In our study, global risk of fracture is increased for patients with IBDs versus controls. This result will help to determine the appropriate assessment with early screening and management of osteoporosis. Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density (BMD). However, the impact on fracture risk is unknown and data are contradictory across studies...
June 16, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29909019/efficacy-of-ustekinumab-in-inducing-endoscopic-healing-in-patients-with-crohn-s-disease
#11
Paul Rutgeerts, Christopher Gasink, Daphne Chan, Yinghua Lang, Paul Pollack, Jean-Frederic Colombel, Douglas C Wolf, Douglas Jacobstein, Jewel Johanns, Philippe Szapary, Omoniyi J Adedokun, Brian G Feagan, William J Sandborn
BACKGROUND & AIMS: We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn's disease (CD). METHODS: We performed an endoscopy sub-study of 334 patients with moderate to severe CD participating in 3 randomized, controlled, phase 3 studies to determine the safety and efficacy of ustekinumab induction and maintenance therapy. All patients underwent colonoscopy at baseline and week 8 of the induction studies and at week 44 of the maintenance study; all colonoscopies were assessed by a blinded central reader...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29906405/dermatologic-manifestations-of-inflammatory-bowel-disease-a-review
#12
Uma Keyal, Yeqiang Liu, Anil Kumar Bhatta
Inflammatory bowel disease (IBD) is a chronic relapsing disease of the gastrointestinal tract with unknown etiology and pathogenesis. It includes Crohn's disease (CD) and ulcerative colitis (UC). Approximately one-third of the patients with IBD are seen to develop extraintestinal manifestations, among which cutaneous manifestations are the most common and should be managed in close collaboration with a dermatologist. Depending upon the nature of the association, skin conditions associated with IBD can be listed under 4 categories: specific, reactive, secondary to malnutrition or malabsorption, and secondary to drug therapy...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29903546/meta-analysis-comparing-the-efficacy-and-adverse-events-of-biologics-and-thiopurines-for-crohn-s-disease-after-surgery-for-ulcerative-colitis
#13
REVIEW
Abhijeet Yadav, Satya Kurada, Joshua Foromera, Kenneth R Falchuk, Joseph D Feuerstein
BACKGROUND: Long-term inflammatory complications of IPAA include Crohn's Disease (CD) or "CD-like" (CDL) condition. We performed a meta-analysis to evaluate the efficacy of anti-tumor necrosis factor (anti-TNF) with or without immunomodulator (IM) therapy in this group of patients. METHODS: Literature databases were searched from inception to October 4, 2017. Further searches using references from papers of interest were conducted and, abstracts from major GI conferences were searched...
May 30, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29901557/association-between-infliximab-drug-and-antibody-levels-and-therapy-outcome-in-pediatric-inflammatory-bowel-diseases
#14
Bella Ungar, Yoav Glidai, Miri Yavzori, Orit Picard, Ella Fudim, Avishay Lahad, Yael Haberman, Dror S Shouval, Ilana Weintraub, Rami Eliakim, Shomron Ben-Horin, Batia Weiss
OBJECTIVES: While infliximab pharmacokinetics are associated with therapy outcome in adult IBD population, limited data is available in pediatric patients. We aimed to define the relationship between Infliximab trough and antibodies' levels (IFX-TL, ATI) and clinical, biomarker remission. METHODS: IFX-TL and ATI were routinely obtained between 2011-2017. Associations with clinical and inflammatory (C-reactive protein, CRP) end-points were studied throughout the first year of infliximab therapy...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29900741/sweet-syndrome-after-treatment-with-vedolizumab-in-a-patient-with-crohn-s-disease
#15
Blanca Martínez Andrés, Violeta Sastre Lozano, José Francisco Sánchez Melgarejo
Sweet syndrome is a common extraintestinal manifestation in inflammatory bowel disease (IBD). In this research, a 42-year-old man case with colon Crohn's disease is been described. After failure with two anti-TNF therapies, in treatment with azathioprim, it was decided to start a therapeutic target change to Vedolizumab due to a severe outbreak refractory to corticosteroids. 24 hours after the infusion of the new drug, skin lesions appear along with leukocytes with neutrophilia, all suggestive of sweet syndrome later confirmed by histology...
June 14, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29899757/different-clinical-outcomes-in-crohn-s-disease-patients-with-esophagogastroduodenal-jejunal-and-proximal-ileal-disease-involvement-is-l4-truly-a-single-phenotype
#16
Ren Mao, Rui-Han Tang, Yun Qiu, Bai-Li Chen, Jing Guo, Sheng-Hong Zhang, Xue-Hua Li, Rui Feng, Yao He, Zi-Ping Li, Zhi-Rong Zeng, Rami Eliakim, Shomron Ben-Horin, Min-Hu Chen
Background: The Montreal classification defines L4 Crohn's disease (CD) as any disease location proximal to the terminal ileum, which anatomically includes L4-esophagogastroduodenal (EGD), L4-jejunal, and L4-proximal ileal involvement. L4-jejunal disease was established to be associated with poor prognosis. However, the outcome of patients with L4-proximal ileal disease or L4-EGD remains to be clarified. Our study aimed to investigate whether the outcome differs among CD patients with L4-EGD, L4-jejunal, and L4-proximal ileal disease...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29899737/dysbiosis-and-ecotypes-of-the-salivary-microbiome-associated-with-inflammatory-bowel-diseases-and-the-assistance-in-diagnosis-of-diseases-using-oral-bacterial-profiles
#17
Zhe Xun, Qian Zhang, Tao Xu, Ning Chen, Feng Chen
Inflammatory bowel diseases (IBDs) are chronic, idiopathic, relapsing disorders of unclear etiology affecting millions of people worldwide. Aberrant interactions between the human microbiota and immune system in genetically susceptible populations underlie IBD pathogenesis. Despite extensive studies examining the involvement of the gut microbiota in IBD using culture-independent techniques, information is lacking regarding other human microbiome components relevant to IBD. Since accumulated knowledge has underscored the role of the oral microbiota in various systemic diseases, we hypothesized that dissonant oral microbial structure, composition, and function, and different community ecotypes are associated with IBD; and we explored potentially available oral indicators for predicting diseases...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29899181/anti-mouse-cd52-treatment-ameliorates-colitis-through-suppressing-th1-17-mediated-inflammation-and-promoting-tregs-differentiation-in-il-10-deficient-mice
#18
Jianhui Liu, Honggang Wang, Yi Li, Peiliang Shi, Jianfeng Gong, Lili Gu, Weiming Zhu, Jieshou Li
Recent studies suggested that excessive Th1/17 cells concomitant with regulatory T cell deficiency might play important roles in Crohn's disease. Anti-CD52 mAb, which aims on CD52 antigen on mature immunocytes, has both T cell depletion and immunosuppressive activities. In this study, we evaluated the therapeutic effects and possible mechanisms of anti-CD52 treatment on interleukin-10 deficient mouse. Anti-mouse CD52 mAb was administered to C3H.IL-10-/- mice intraperitoneally 20μg per week for 2 weeks. The disease activity index, body weight, the histological grading of colitis, and levels of TNF-α, IFN-γ, IL-17 and IL-6 in colon were quantified after treatment...
June 13, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29899011/proteus-spp-as-putative-gastrointestinal-pathogens
#19
REVIEW
Amy L Hamilton, Michael A Kamm, Siew C Ng, Mark Morrison
Proteus species, members of the Enterobacteriaceae family, are usually considered commensals in the gut and are most commonly recognized clinically as a cause of urinary tract infections. However, the recent identification of Proteus spp. as potential pathogens in Crohn's disease recurrence after intestinal resection serves as a stimulus to examine their potential role as gut pathogens. Proteus species possess many virulence factors potentially relevant to gastrointestinal pathogenicity, including motility; adherence; the production of urease, hemolysins, and IgA proteases; and the ability to acquire antibiotic resistance...
July 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29897134/clinical-disease-activity-is-associated-with-anxiety-and-depressive-symptoms-in-adolescents-and-young-adults-with-inflammatory-bowel-disease
#20
G van den Brink, L Stapersma, L E Vlug, D Rizopolous, A G Bodelier, H van Wering, P C W M Hurkmans, R J L Stuyt, D M Hendriks, J A T van der Burg, E M W J Utens, J C Escher
BACKGROUND: Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%-50% prevalence rate. AIMS: This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression. METHODS: IBD patients (n = 374; 10-25 years) were screened for anxiety, depression and quality of life using validated age-specific questionnaires...
June 13, 2018: Alimentary Pharmacology & Therapeutics
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