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Qingfu Ban, Wen Sun, Jie Kong, Si Wu
Hyperbranched polymers (HPs) have been widely used for drug delivery due to their highly branched topology, which endows the HPs with a large amount of intramolecular cavities for drug encapsulation and terminal groups for drug conjugation. Additionally, the one-pot and large-scale preparation features enable the easy fabrication of HPs for biomedical applications. This review provides an overview of the synthesis of HPs and their application for drug delivery. First, we introduce the diversity of synthesis of HPs with controllable topologies...
June 17, 2018: Chemistry, An Asian Journal
Ahmet Imerci, Nevres Hurriyet Aydogan, Kursad Tosun
Background: The aim of this study was to evaluate the agreement between the fracture-risk assessment tool (FRAX®)-based intervention strategy in Turkey and the recommendations published in the Healthcare Practices Statement (HPS). Methods: This descriptive cross-sectional study included individuals aged 40 to 90 years who were previously diagnosed as having osteoporosis but had not received any treatment. The intervention thresholds recommended by the National Osteoporosis Foundation for treatment were used...
May 2018: Journal of Bone Metabolism
Ibrahim Azboy, Michael M Kheir, Ronald Huang, Javad Parvizi
There are no clear guidelines regarding optimal venous thromboembolism (VTE) prophylaxis for patients undergoing hip preservation surgery (HPS), in particular pelvic osteotomy, which is considered to be a major orthopaedic procedure. The aim of this study was to determine the efficacy of aspirin for VTE prophylaxis in a large cohort of patients undergoing femoroacetabular osteoplasty (FAO) and periacetabular osteotomy (PAO). This was a retrospective study of prospectively collected data on patients undergoing HPS...
July 2018: Journal of Hip Preservation Surgery
Ashley Cameron, Kyla Hudson, Emma Finch, Jennifer Fleming, Jennifer Lethlean, Steven McPhail
BACKGROUND: Communication partner training (CPT) has been used to support communication partners to interact successfully with people with aphasia (PWA). Through successful CPT interaction PWA's accessibility to healthcare is notably improved. The present study sought to build on prior studies by investigating the experiences of individuals with aphasia and healthcare providers to ascertain what they deemed to be beneficial from CPT and what could be refined or improved, dependent on the setting and skill set of those participating...
June 5, 2018: International Journal of Language & Communication Disorders
Takanori Nakajima
 Hospital preparations (HPs) prepared by hospital pharmacists have contributed to advanced medical care which is custom tailored to various and individual medical needs. Advanced pharmaceutical knowledge and skills are needed to properly prepare HPs. Hospital pharmacists have inherited formulations and the skills to prepare them from their predecessors. However, there has been an ongoing decrease in the number of HPs prepared in hospitals due to an increase in the availability of commercial formulations. Despite this trend, it is not acceptable for hospital pharmacists to lack experience when a doctor requests an original HP...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Daniel J Van Dussen, John Cagle, Amy J Plant, Seokho Hong, Krystal L Culler, Iraida V Carrion
The Hospice Philosophy Scale (HPS) is the only scaled instrument that measures health professionals' attitudes about end-of-life care consistent with the hospice philosophy. This study tested the properties of a modified version of the HPS to provide preliminary validation data on internal consistency, convergent validity, and factorability in a broad population of adults. A cross-sectional telephone survey designed to assess the general population's attitudes regarding hospice use was administered. exploratory factor analysis elicited an eight-item instrument (HPS-8)...
June 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
Filiz Mercantepe, Tolga Mercantepe, Atilla Topcu, Adnan Yılmaz, Levent Tumkaya
Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This study investigated the effects of cisplatin on the kidney, the damage mechanism involved, and the potential capacity of agents such as amifostine, curcumin, and melatonin to elicit a future therapeutic protocol in cisplatin-induced nephrotoxicity at the ultrastructural and molecular levels. Our study consisted of five groups: control (saline solution only; group 1), cisplatin (cisplatin only; group 2), cisplatin + amifostine (group 3), cisplatin + curcumin (group 4), and cisplatin + melatonin (group 5)...
June 2, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Norelee M Kennedy, Sean G McKenna, Aoife O'Neill, Bente Appel Esbensen, Thijs Willem Swinnen, Birgitta Nordgren, Sara Willemijns, Nanna Maria Hammer, Nina Brodin
OBJECTIVES: The objectives of this study were to determine rheumatology health professionals' (HPs)' awareness of and confidence in using physical activity (PA) measures in people with inflammatory joint diseases (IJDs), their own self-reported PA levels and to identify HP-related educational needs. METHODS: Rheumatology HPs in Denmark, Sweden, Ireland and Belgium participated in an on-line survey. Descriptive statistics and latent class analysis (LCA) were undertaken SPSS (v21and SASv9...
May 31, 2018: BMJ Open
N D B Ehelepola, B M L S Basnayake, S M B Y Sathkumara, K L R Kaluphana
There are two categories of hantaviruses resulting in two distinct illnesses. The Old World (Asia and Europe) viruses give rise to hemorrhagic fever with renal syndrome (HFRS), and the New World (Americas) viruses cause hantavirus pulmonary syndrome (HPS). Hantavirus infections have very similar clinical pictures and epidemiology to leptospirosis. Here, we present two cases of hantavirus infections from Sri Lanka (in South Asia) initially misdiagnosed as leptospirosis and later further investigated and diagnosed as hantavirus infections with serological confirmation of the diagnosis...
2018: Case Reports in Infectious Diseases
Caroline Phillips, Clare Harris, Nathaniel Broughton, Thomas Pulimood, Liam Ring
We present the case of a 68-year-old gentleman who presented with breathlessness and was found to have NSTEMI, pulmonary oedema, and hypoxia. He remained hypoxic despite appropriate treatment and was found to have preserved LV function and raised cardiac output. CT pulmonary angiogram was negative but a cirrhotic liver was incidentally noted and later confirmed via ultrasound. Bedside examination was positive for orthodeoxia, suggesting a diagnosis of hepatopulmonary syndrome (HPS). The finding of significant intrapulmonary shunting on "bubble" echocardiography confirmed the diagnosis...
2018: Case Reports in Critical Care
Nicole Dorinzi, Justine Pagenhardt, Melinda Sharon, Kristine Robinson, Erin Setzer, Nicolas Denne, Joseph Minardi
A 15-day-old male who was born at term presented with non-bilious projectile vomiting. He was nontoxic and his abdomen was benign without masses. Point-of-care ultrasound (POCUS) showed hypertrophic pyloric stenosis (HPS). Typical findings include target sign; pyloric muscle thickness greater than three millimeters (mm); channel length greater than 15-18 mm; and lack of gastric emptying. The patient was admitted; consultative ultrasound (US) was negative, but repeated 48 hours later for persistent vomiting...
November 2017: Clinical practice and cases in emergency medicine
Jaeho Choi, Ji Su Han, Kootak Hong, Soo Young Kim, Ho Won Jang
Fascinating characteristics of halide perovskites (HPs), which cannot be seen in conventional semiconductors and metal oxides, have boosted the application of HPs in electronic devices beyond optoelectronics such as solar cells, photodetectors, and light-emitting diodes. Here, recent advances in HP-based memory and logic devices such as resistive-switching memories (i.e., resistive random access memory (RRAM) or memristors), transistors, and artificial synapses are reviewed, focusing on inherently exotic properties of HPs: i) tunable bandgap, ii) facile majority carrier control, iii) fast ion migration, and iv) superflexibility...
May 30, 2018: Advanced Materials
Christophe Attencourt, Charles Sabbagh, Jonathan Meynier, Lucien Grados, Jean-Marc Regimbeau, Denis Chatelain
The aim of our study was to assess the value of Elastic stain in the diagnosis of venous invasion (VI) in colonic adenocarcinoma. MATERIAL AND METHODS: All patients who undergone surgery for colonic adenocarcinoma at the University Hospital of Amiens, between 2004 and 2007, were included. Hematein-phloxin-saffron (HPS) stained slides of colectomy specimens were reviewed by two pathologists. Tumor blocks were stained with Elastic Stain (Roche - Ventana® ). The presence or absence of VI, their number and localization were correlated with overall survival...
May 26, 2018: Annales de Pathologie
Shuichiro Nagata, Keiichi Mitsuyama, Hiroshi Kawano, Tetsuhiro Noda, Yasuhiko Maeyama, Michita Mukasa, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Jun Akiba, Osamu Tsuruta, Takuji Torimura
Serrated lesions, including hyperplastic polyps (HPs), traditional serrated adenomas (TSAs) and sessile serrated adenomas/polyps (SSA/Ps), are important contributors to colorectal carcinogenesis. The aim of the present study was to analyze the potential of conventional endoscopy and advanced endoscopic imaging techniques to delineate the characteristic features of serrated lesions with cancer. The present study was a retrospective analysis of the data of 168 patients who had undergone colonoscopy, and a total of 228 serrated lesions (77 HPs, 58 TSAs, 84 SSA/Ps, 9 SSA/P plus TSAs) have been identified in these patients...
June 2018: Oncology Letters
Scott D Nelson, Taylor Woodroof, Wing Liu, Christoph U Lehmann
PURPOSE: The extent to which medication prescriptions had a reason for the medication use documented in form of a potential indication within the electronic health record (EHR) problem lists using a MEDication Indication (MEDI) resource was evaluated. METHODS: Prescriptions from January 1 to June 30, 2015, comparing them to patients' problem lists using MEDI and the MEDI High Precision Subset (MEDI-HPS) were analyzed. RxNorm generic ingredient name codes in MEDI were used to map prescriptions to problems using codes from the International Classification of Diseases, 9th edition ...
June 1, 2018: American Journal of Health-system Pharmacy: AJHP
Liang Ma, Min Zhang, Shuyong Zhao
BACKGROUND: Cordyceps militaris is a medicine and food dual-purpose mushroom extensively cultivated and consumed in East and Southeast Asia for centuries. However, it has an extremely short shelf life of 3-4 days at room temperature. Cordyceps militaris was pasteurized for 10, 20 and 30 min by radio frequency (RF) at the electrode gap of 20 mm. The effect of radio frequency heating on the microbial load, color, texture and flavor attributes of Cordyceps militaris was evaluated and compared with those sterilized by conventional high pressure steam (HPS)...
May 24, 2018: Journal of the Science of Food and Agriculture
Dena Javadi, Nhan Tran, Abdul Ghaffar
INTRODUCTION: The era of the Sustainable Development Goals calls for multidisciplinary research and intersectoral approaches to addressing health challenges. This presents a unique opportunity for multidisciplinary fields concerned with complex systems. Those working in system-oriented fields such as health policy and systems research (HPSR) and health services research must be forward-thinking in optimizing their collective ability to address these global challenges. OBJECTIVES: The objective of this commentary was to share reflections on challenges and strategies in managing the HPSR workforce in order to stimulate dialogue and cross-learning across similar fields...
May 24, 2018: Health Services Research
Yang Liu, Xiao-Yue Wang, Xue-Min Wei, Zi-Tong Gao, Jian-Ping Han
Species adulteration in herbal products (HPs) exposes consumers to health risks. Chemical and morphological methods have their own deficiencies when dealing with the detection of species containing the same active compounds in HPs. In this study, we developed a rapid identification method using the recombinase polymerase amplification (RPA) assay to detect two species, Ginkgo biloba and Sophora japonica (as adulteration), in Ginkgo biloba HPs. Among 36 Ginkgo biloba HP samples, 34 were found to have Ginkgo biloba sequences, and 9 were found to have Sophora japonica sequences...
May 22, 2018: Scientific Reports
Xufeng Xue, Yubing Sun, Agnes M Resto-Irizarry, Ye Yuan, Koh Meng Aw Yong, Yi Zheng, Shinuo Weng, Yue Shao, Yimin Chai, Lorenz Studer, Jianping Fu
Classic embryological studies have successfully applied genetics and cell biology principles to understand embryonic development. However, it remains unresolved how mechanics, as an integral driver of development, is involved in controlling tissue-scale cell fate patterning. Here we report a micropatterned human pluripotent stem (hPS)-cell-based neuroectoderm developmental model, in which pre-patterned geometrical confinement induces emergent patterning of neuroepithelial and neural plate border cells, mimicking neuroectoderm regionalization during early neurulation in vivo...
May 21, 2018: Nature Materials
Fabio M Leonelli, Giuseppe Bagliani, Roberto De Ponti, Luigi Padeletti
From the atrioventricular node, electrical activation is propagated to both ventricles by a system of specialized conducting fibers, His Purkinje System (HPS), guaranteeing a fast, synchronous depolarization of both ventricles. From the predivisional common stem, a right and left branch separate, subdividing further in a fairly predictable fashion. Synchronous ventricular activation results in a QRS with specific characteristics and duration of less than 110 milliseconds. Block or delay in any part of the HPS changes the electrocardiographic (ECG) morphology...
June 2018: Cardiac Electrophysiology Clinics
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