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https://www.readbyqxmd.com/read/28642034/cyclooxygenase-2-promotes-pulmonary-intravascular-macrophage-accumulation-by-exacerbating-bmp-signaling-in-rat-experimental-hepatopulmonary-syndrome
#1
Chang Liu, Jing Gao, Bing Chen, Lin Chen, Karine Belguise, Weifeng Yu, Kaizhi Lu, Xiaobo Wang, Bin Yi
BACKGROUND AND AIMS: One central factor in hepatopulmonary syndrome (HPS) pathogenesis is intravascular accumulation of activated macrophages in small pulmonary arteries. However, molecular mechanism underlyingthe macrophage accumulation in HPS is unknown. In this study, we aimed to explore whether elevated COX-2 induces the Bone morphogenicprotein-2 (BMP-2)/Crossveinless-2(CV-2) imbalance and then activation of BMP signaling pathway promotes the macrophage accumulation in Common Bile Duct Ligation (CBDL) rat lung...
June 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28640947/clinico-molecular-analysis-of-eleven-patients-with-hermansky-pudlak-type-5-syndrome-a-mild-form-of-hps
#2
Vincent Michaud, Eulalie Lasseaux, Claudio Plaisant, Alain Verloes, Yaumara Perdomo-Trujillo, Christian Hamel, Nursel H Elcioglu, Bart Leroy, Josseline Kaplan, Pierre-Simon Jouk, Didier Lacombe, Patricia Fergelot, Fanny Morice-Picard, Benoit Arveiler
Hermansky-Pudlak syndrome (HPS), first described in 1959, is a rare form of syndromic oculocutaneous albinism associated with bleeding diathesis and in some cases pulmonary fibrosis and granulomatous colitis. All 10 HPS types are caused by defects in vesicle trafficking of lysosomes-related organelles (LRO) proteins. The HPS5 protein associates with HPS3 and HPS6 to form the Biogenesis of Lysosome-related Organelles Complex-2 (BLOC-2). Here we report the clinical and genetic data of 11 HPS-5 patients analyzed in our laboratory...
June 22, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28639982/transforming-the-nursing-classroom-into-a-clinical-setting
#3
Leslie G Cole, B Ann Graves, Stephanie Turner
Providing clinical opportunities for students to gain experience in managing cardiac dysrhythmias is a challenge for nursing faculty. High-risk experiences are often not available for all students or are too life-threatening to entrust to students. Faculty shortages and increasing enrollments add to declines in clinical opportunities. The use of human patient simulation (HPS) has added opportunities to experience high-risk, low-frequency clinical situations. HPS may be employed in the classroom setting to teach content related to dysrhythmia treatments...
June 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28639219/signature-pattern-analysis-for-the-full-length-env-gene-of-the-earliest-korean-subclade-b-of-hiv-1-outbreak-among-korean-hemophiliacs
#4
Young-Keol Cho, Jung-Eun Kim, Daeun Jeong, Brian T Foley
The epidemiological link in the hypervariable env gene between viruses infecting HIV-positive hemophiliacs (HPs) and plasma donors was not studied. We determined full-length env gene sequences in 20 HPs, 3 plasma donors whose plasma was used for domestic clotting factor (DCF) production, and 54 local controls (LCs). Env genes from viruses in frozen stored sera obtained 1-3 years after diagnosis and from samples collected several years after infection were amplified via RT-PCR and subjected to direct sequencing...
June 21, 2017: Virus Genes
https://www.readbyqxmd.com/read/28637517/priorities-for-african-youth-for-engaging-in-dohad
#5
A J Macnab, R Mukisa
A challenge for implementing DOHaD-defined health promotion is how to engage the at-risk population. The WHO Health Promoting School (HPS) model has proven success engaging youth and improving health behaviors. Hence, we introduced DOHaD concepts to 151 pupils aged 12-15 years in three HPS programs in rural Uganda, inquired what factors would make DOHaD-related health promotion resonate with them, and discussed how they recommended making learning about DOHaD acceptable to youth. Economic factors were judged the most compelling; with nutrition and responsive care elements next in importance...
June 22, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28633292/ahp2-ahp3-and-ahp5-act-downstream-of-cki1-in-arabidopsis-female-gametophyte-development
#6
Zhenning Liu, Li Yuan, Xiaoya Song, Xiaolin Yu, Venkatesan Sundaresan
Histidine phosphotransfer proteins (HPs) are key elements of the two-component signaling system, which act as a shuttle to transfer phosphorylation signals from histidine kinases (HKs) to response regulators (RRs). CYTOKININ INDEPENDENT 1 (CKI1), a key regulator of central cell specification in the Arabidopsis female gametophyte, activates the cytokinin signaling pathway through the Arabidopsis histidine phosphotransfer proteins (AHPs). There are five HP genes in Arabidopsis, AHP1-AHP5, but it remains unknown which AHP genes act downstream of CKI1 in Arabidopsis female gametophyte development...
June 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28632747/selective-cyclooxygenase-inhibition-by-sc-560-improves-hepatopulmonary-syndrome-in-cirrhotic-rats
#7
Ching-Chih Chang, Wen-Shin Lee, Hsian-Guey Hsieh, Chiao-Lin Chuang, Hui-Chun Huang, Fa-Yauh Lee, Shou-Dong Lee
OBJECTIVE: Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammation and angiogenesis, which can be modulated by COX inhibitors. We therefore evaluated the impact of COX inhibition in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS...
2017: PloS One
https://www.readbyqxmd.com/read/28631264/targeted-use-of-leds-in-improvement-of-production-efficiency-through-phytochemical-enrichment
#8
REVIEW
E Taulavuori, K Taulavuori, J K Holopainen, R Julkunen-Tiitto, C Acar, I Dincer
Based on available literature, ecology and economy of LED (light emitting diode) lights in plant foods production were assessed and compared to HPS (high pressure sodium) and CFL (compact fluorescent light) lamps. The assessment summarises that LEDs are superior compared to other lamp types. LEDs are ideal in luminous efficiency, life span and electricity usage. Mercury, carbon dioxide and heat emissions are also lowest in comparison to HPS and CFL lamps. This indicates that LEDs are indeed economic and eco-friendly lighting devices...
June 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28627675/distinctive-crypt-shape-in-a-sessile-serrated-adenoma-polyp-distribution-of-ki67-p16ink4a-wnt5a-positive-cells-and-intraepithelial-lymphocytes
#9
Kenji Hisamatsu, Kei Noguchi, Hiroyuki Tomita, Aoi Muto, Natsumi Yamada, Kazuhiro Kobayashi, Akihiro Hirata, Tomohiro Kanayama, Ayumi Niwa, Kazuhisa Ishida, Takayuki Nakashima, Yuichiro Hatano, Natsuko Suzui, Tatsuhiko Miyazaki, Akira Hara
Serrated lesions in the colorectum are currently predominantly classified as hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs) according to their morphology. However, the histological morphology and the molecular changes in the serrated lesions are still unclear. We performed immunohistochemistry for Ki67, p16INK4a, and WNT5A in human HPs (n=22), SSA/Ps (n=41), and TSAs (n=19). The distribution of Ki67 and p16INK4a positive cells in TSAs was different from that in HPs and SSA/Ps...
June 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28626190/miliary-tuberculosis-in-a-young-woman-with-hemophagocytic-syndrome-a-case-report-and-literature-review
#10
Mina Asaji, Kazunori Tobino, Koujin Murakami, Yuki Goto, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Miyuki Munechika, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Hiroyuki Miyajima, Noriyuki Ebi
We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28626188/discoid-lupus-erythematosus-complicated-with-pregnancy-induced-hemophagocytic-syndrome
#11
Hideto Takada, Naoki Kimura, Yoko Yoshihashi-Nakazato, Kimito Kawahata, Hitoshi Kohsaka
A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). She had no findings of infection or active systemic lupus erythematosus. The administration of high-dose corticosteroids resolved the clinical and laboratory findings. She delivered a healthy baby at 35 weeks' gestation. This case suggests that DLE can be a predisposing factor for pregnancy-induced HPS...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28622015/the-first-whole-genome-sequence-and-pathogenicity-characterization-of-a-fowl-adenovirus-4-isolated-from-ducks-associated-with-inclusion-body-hepatitis-and-hydropericardium-syndrome
#12
Qing Pan, Linlin Liu, Yongqiang Wang, Yanping Zhang, Xiaole Qi, Changjun Liu, Yulong Gao, Xiaomei Wang, Hongyu Cui
In June 2015, an infectious disease with high prevalence causing severe hydropericardium syndrome (HPS) first appeared in duck farms of northeast China. The disease showed high morbidity of 35% and mortality of 15% in a commercial duck farm with 200,000 45-day-old ducks. One strain of hypervirulent fowl adenovirus serotype 4 was identified and designated as HLJDAd15. The whole genome of the duck isolate was sequenced and found to contain the same large deletions as a genotype that has become prevalent in chickens in China recently, indicating that this disease might be transmitted from chickens to ducks...
June 16, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28618783/pulsed-light-emitting-diodes-for-higher-phytochemical-level-in-microgreens
#13
Viktorija Vaštakaitė, Akvilė Viršilė, Aušra Brazaitytė, Giedrė Samuolienė, Julė Jankauskienė, Algirdas Novičkovas, Pavelas Duchovskis
A novel research of pulsed LED lighting versus continuous lighting was conducted by analyzing phytochemicals levels in microgreens. Red pak choi (Brassica rapa var. chinensis), mustard (Brassica juncea L.) and tatsoi (Brassica rapa var. rosularis) were grown indoors under HPS lamps supplemented with monochromatic (455 nm, 470 nm, 505 nm, 590 nm and 627 nm) LEDs (total PPFD 200±10 µmol m(-2) s(-1); 16 h day(-1)). For pulsed light treatments, the frequencies at 2 Hz, 32 Hz, 256 Hz, and 1024 Hz with a duty cycle of 50% of monochromatic LEDs were applied...
June 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28618698/re-greenlight-high-performance-system-hps-120-w-laser-vaporization-versus-transurethral-resection-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-meta-analysis-of-the-published-results-of-randomized-controlled-trials
#14
https://www.readbyqxmd.com/read/28611257/isolated-intrapulmonary-vascular-dilatations-and-the-risk-of-developing-hepatopulmonary-syndrome-in-liver-transplant-candidates
#15
Manuel Mendizabal, David Goldberg, Federico Piñero, Diego Arufe, María José de la Fuente, Pablo Testa, Matías Coronel, Sergio Baratta, Luis Podestá, Michael Fallon, Marcelo Silva
BACKGROUND: The natural history of intrapulmonary vascular dilations (IPVD) and their impact on patient outcomes in the setting of portal hypertension has only been described in small series. AIMS: To assess the development of hepatopulmonary síndrome (HPS) in patients with isolated IPVD and to evaluate outcomes of IPVD and HPS among patients evaluated for liver transplantation (LT). MATERIAL AND METHODS: Data from a prospective cohort of patients evaluated for LT with standardized screening for HPS were analyzed...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28606083/the-spiritual-history-in-outpatient-practice-attitudes-and-practices-of-health-professionals-in-the-adventist-health-system
#16
Harold G Koenig, Kathleen Perno, Ted Hamilton
BACKGROUND: A screening spiritual history (SSH) is how health professionals (HP) identify patients' spiritual values, beliefs and preferences (VBPs) in the outpatient setting. We report on attitudes and practices of HPs in the largest Protestant health system in the U.S., the Adventist Health System (AHS). METHOD: Physicians or mid-level practitioners (N = 1082) in AHS-affiliated practices were approached and 513 (47%) agreed to participate. Participants were asked to identify a "spiritual care coordinator" (nurse/staff) and complete a questionnaire that assessed demographics, practice characteristics, religious involvement, and attitudes/practices concerning the SSH...
June 12, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28604596/optimized-photodynamic-therapy-with-multifunctional-cobalt-magnetic-nanoparticles
#17
Kyong-Hoon Choi, Ki Chang Nam, Un-Ho Kim, Guangsup Cho, Jin-Seung Jung, Bong Joo Park
Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy...
June 10, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28599039/manikin-human-patient-simulator-training
#18
Gregory T Horn
BACKGROUND: Human-patient simulators (HPSs) may help enhance medical education. Manikin HPS devices respond to common field medical interventions, such as cricothyroidotomy, and have realistic feedback features, such as respirations and pulses. This study surveys Special Operations Medics for evaluations of HPS features. METHODS: Of 518 subjects, 376 completed testing and surveys with valid responses. A total of 102 variables were divided into three categories-general characteristics, procedures, and injuries-and assessed on a fivepoint Likert scale...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28598556/can-preoperative-detrusor-underactivity-influence-surgical-outcomes-of-120%C3%A2-w-hps-vaporization-of-the-prostate-pvp-or-holmium-laser-enucleation-of-the-prostate-holep-a-serial-3-year-follow-up-study
#19
Min Chul Cho, Juhyun Park, Jung Kwon Kim, Sung Yong Cho, Hyeon Jeong, Seung-June Oh, Jae-Seung Paick, Hwancheol Son
AIMS: To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. METHODS: A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88)...
June 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28595116/the-unique-spliceosome-signature-of-human-pluripotent-stem-cells-is-mediated-by-snrpa1-snrpd1-and-pnn
#20
Young-Dae Kim, Jungwoon Lee, Han-Seop Kim, Mi-Ok Lee, Mi-Young Son, Chae Hwa Yoo, Jung-Kyun Choi, Sang Chul Lee, Yee Sook Cho
Spliceosomes are the core host of pre-mRNA splicing, allowing multiple protein isoforms to be produced from a single gene. Herein, we reveal that spliceosomes are more abundant in human pluripotent stem cells (hPSs), including human embryonic stem cells (hESs) and human induced pluripotent stem cells (hiPSs), than non-hPSs, and their presence is associated with high transcriptional activity. Supportively, spliceosomal components involved in the catalytically active pre-mRNA splicing step were mainly co-localized with hPS spliceosomes...
May 30, 2017: Stem Cell Research
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