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Svetlana Filatova, Heli Koivumaa-Honkanen, Golam M Khandaker, Estelle Lowry, Tanja Nordström, Tuula Hurtig, Kristiina Moilanen, Jouko Miettunen
Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557-4674)...
December 9, 2017: Schizophrenia Bulletin
Renata Pereira da Silva-Marques, Joanis Tilemahos Zervoudakis, Luciana Keiko Hatamoto-Zervoudakis, Pedro Ivo José Lopes da Rosa E Silva, Núbia Bezerra do Nascimento Matos, Andresa Lazzarotto Feliciano, Rones Goulart de Paula Júnior, Luciano da Silva Cabral
Supplementation of animals in the rainy season is essential to maximise weight gain. Thus, the objective was to evaluate the effects of supplementation with low-, medium- and high-protein levels on nutritional parameters of grazing beef cattle in the rainy season. Eight rumen-cannulated Nellore bulls (437 kg body weight) were used in a 4 × 4 double Latin square design with four supplements and four experimental periods. The treatments were mineral supplement (ad libitum) and supplements with low-protein (LPSU), medium-protein (MPS) and high-protein (HPS) levels, providing 106, 408 and 601 g/day of crude protein (CP), respectively...
December 12, 2017: Tropical Animal Health and Production
Cheng-Cheng Shen, Bing Chen, Jian-Teng Gu, Jiao-Lin Ning, Jing Zeng, Bin Yi, Kai-Zhi Lu
Recent studies have shown that pulmonary angiogenesis is an important pathological process in the development of hepatopulmonary syndrome (HPS), and growing evidence has indicated that Stromal cell-derived factor 1/C-X-C chemokine receptor type 4 (SDF-1/CXCR4) axis is involved in pulmonary vascular disease by mediating the accumulation of c-kit+cells. This study aimed to test the effect of AMD3100, an antagonist of CXCR4, in HPS pulmonary angiogenesis. Common bile duct ligation (CBDL) rats were used as experimental HPS model and were treated with AMD3100 (1...
December 9, 2017: Biochimica et Biophysica Acta
Daisuke Tsukamoto, Michihiko Ito, Nobuhiko Takamatsu
The chipmunk hibernation-related proteins (HPs) HP-20 and HP-27 are components of a 140-kDa complex that dramatically decreases in the blood during hibernation. The HP-20 and HP-27 genes are expressed specifically in the liver and are downregulated in hibernating chipmunks. Hibernation-associated physiological changes are assumed to be under genetic control. Therefore, to elucidate the molecular mechanisms of hibernation, here we examined the mechanisms behind the altered HP-20 and HP-27 gene expression in nonhibernating versus hibernating chipmunks...
December 9, 2017: Biochemical and Biophysical Research Communications
Karin L Collins, Ann Zweber, Adriane N Irwin
OBJECTIVE: Determine the impact of a short longitudinal literary fiction intervention on empathy development in student pharmacists as measured by the Jefferson Scale of Empathy - Health Profession Students (JSE-HPS) version. METHODS: Twenty-one student pharmacists were randomized to an intervention consisting of reading short excerpts of literary fiction over eight weeks (n=11) or a control group not participating in the intervention (n=10). Both groups completed the JSE-HPS at baseline and completion of the literary intervention...
May 2017: Currents in Pharmacy Teaching & Learning
Grzegorz Piotrowicz, Tomasz Syryło, Rafał Jedynak, Henryk Zieliński
OBJECTIVE: The objective of this study was to evaluate the safety and effectiveness of photoselective vaporization of the prostate (PVP) in the treatment of patients with benign prostatic hyperplasia (BPH) on anticoagulant or antiplatelet therapy. BACKGROUND: The "gold standard" of surgical treatment of BPH is transurethral resection of the prostate (TURP). Since the risk of complications associated with TURP is still significant, there is a continuous search for safer and equally effective procedures...
December 11, 2017: Photomedicine and Laser Surgery
Sukanya Horpaopan, Jutta Kirfel, Sophia Peters, Michael Kloth, Robert Hüneburg, Janine Altmüller, Dmitriy Drichel, Margarete Odenthal, Glen Kristiansen, Christian Strassburg, Jacob Nattermann, Per Hoffmann, Peter Nürnberg, Reinhard Büttner, Holger Thiele, Philip Kahl, Isabel Spier, Stefan Aretz
Background: Serrated or Hyperplastic Polyposis Syndrome (SPS, HPS) is a yet poorly defined colorectal cancer (CRC) predisposition characterised by the occurrence of multiple and/or large serrated polyps throughout the colon. A serrated polyp-CRC sequence (serrated pathway) of CRC formation has been postulated, however, to date only few molecular signatures of serrated neoplasia (BRAF, KRAS, RNF43 mutations, CpG Island Methylation, MSI) have been described in a subset of SPS patients and neither the etiology of the syndrome nor the distinct genetic alterations during tumorigenesis have been identified...
2017: Hereditary Cancer in Clinical Practice
Antje Aarthun, Knut A Øymar, Kristin Akerjordet
In many western countries, parents have a legal right to influence and be involved in decision-making (DM) surrounding their children's healthcare. This ensures that the healthcare is customized as far as possible to meet the children's and families' needs and preferences. However, parental involvement in such DM is not sufficiently implemented and the parental role during hospitalizations has become demanding. More knowledge is required to inform health professionals (HPs) about how to improve parental involvement in DM from a health-promoting perspective...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
Shun Yamashita, Naoko E Furukawa, Tomoyo Matsunaga, Yuka Hirakawa, Masaki Tago, Shu-Ichi Yamashita
BACKGROUND Adult-onset Still's disease (AOSD) is a rare multi-systemic inflammatory disorder of unknown etiology characterized by spiking fever, characteristic rash, and arthritis. It often associates with high serum ferritin levels. CASE REPORT An 88-year-old woman had fever of over 39°C without response to extended-spectrum antibiotics for 6 days. She had non-specific erythema with infiltration on her trunk. She had leukocytosis with neutrophilia of 80%, mild hepatic dysfunction, normal level of rheumatoid factor and antinuclear antibody, thrombocytopenia, elevated d-dimer and soluble interleukin2 receptor, extremely high serum ferritin (78 662 ng/mL), and splenomegaly...
December 6, 2017: American Journal of Case Reports
Małgorzata Pomorska-Mól, Arkadiusz Dors, Krzysztof Kwit, Ewelina Czyżewska-Dors, Zygmunt Pejsak
BACKGROUND: Respiratory co-infections are important factor affecting the profitability of pigs production. Swine influenza virus (SIV) may predispose to secondary infection. Haemophilus parasuis (Hps) can be a primary pathogen or be associated with other pathogens such as SIV. To date, little is known about the effect of coinfection with SIV and Hps on the disease severity and inflammatory response and the role of Hps in the induction of pneumonia in the absence of other respiratory pathogens...
December 4, 2017: BMC Veterinary Research
Eric M Mafuta, Marjolein A Dieleman, Leon Essink, Paul N Khomba, François M Zioko, Thérèse N M Mambu, Patrick K Kayembe, Tjard de Cock Buning
Background: Social accountability (SA) comprises a set of mechanisms aiming to, on the one hand, enable users to raise their concerns about the health services provided to them (voice), and to hold health providers (HPs) accountable for actions and decisions related to the health service provision. On the other hand, they aim to facilitate HPs to take into account users' needs and expectations in providing care. This article describes the development of a SA intervention that aims to improve health services responsiveness in two health zones in the Democratic Republic of the Congo...
2017: Global Health Research and Policy
Yoji Komiya, Tetsuya Saito, Fumitaka Mizoguchi, Hitoshi Kohsaka
A 57-year-old woman was admitted to our hospital because of a high fever, anemia, and hyperferritinemia. Since a bone marrow examination revealed hemophagocytosis, she was diagnosed with hemophagocytic syndrome (HPS). During treatment of HPS, a heliotrope rash and Gottron's sign appeared with elevated levels of serum aldolase. She also developed heart failure. She was diagnosed with dermatomyositis (DM) and associated myocarditis. Although the administration of glucocorticoids, calcineurin inhibitors, intravenous immunoglobulins, and etoposide ameliorated the clinical findings of DM and cytopenia, the fever and hyperferritinemia remained...
2017: Internal Medicine
Gunnar Schalasta, Anna Börner, Andrea Speicher, Martin Enders
BACKGROUND: Proper management of patients with chronic hepatitis B virus (HBV) infection requires monitoring of plasma or serum HBV DNA levels using a highly sensitive nucleic acid amplification test. Because commercially available assays differ in performance, we compared herein the performance of the Hologic Aptima HBV Quant assay (Aptima) to that of the Roche Cobas TaqMan HBV test for use with the high pure system (HPS/CTM). METHODS: Assay performance was assessed using HBV reference panels as well as plasma and serum samples from chronically HBV-infected patients...
December 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
Jingqiu Jiang, Hongxia Zhao, Shibin Sun, Yuntao Wang, Sisi Liu, Qing Xie, Xiangkun Li
Halogenated organic pollutants (HOPs), as ubiquitous environment contaminants, have attracted increasing concerns due to the potential adverse health impacts on organisms and even humans. Waste water treatment plants (WWTPs) are one source of HOPs to the environment through their discharge of treated effluent. In this study, the presence and profiles of 6 halogenated phenols (HP), 17 polybrominated diphenyl ethers (PBDE) and 11 hydroxylated polybrominated diphenyl ethers (OH-PBDE) were investigated in 12 WWTP effluent samples collected near Huang-Bo Sea in Dalian, China...
November 30, 2017: Science of the Total Environment
Line R Knudsen, Annette de Thurah, Kirsten Lomborg
OBJECTIVE: The aim was to explore the experiences of a patient-reported outcome (PRO)-based tele-health follow-up from the perspective of patients with rheumatoid arthritis (RA) and their experiences of increasing their active role and responsibility for disease control in particular. METHODS: Adopting a strategy of interpretive description, we conducted individual, semi-structured interviews with 15 RA patients participating in a tele-health follow-up. Participants were selected purposively and consecutive from both genders and with various ages, disease durations and disease severity...
December 1, 2017: Arthritis Care & Research
Ki Tae Suk, Moon Young Kim, Soung Won Jeong, Jae Young Jang, Yoon Ok Jang, Soon Koo Baik
BACKGROUND/AIMS: Hepatopulmonary syndrome (HPS) is characterized by a defect in oxygenation induced by pulmonary vascular dilatation in cirrhosis. While severe HPS is responsible for a high rate of mortality, the prevalence and pathophysiology of HPS are not fully elucidated. We evaluated the prevalence and pathophysiology of HPS in patients with cirrhosis. METHODS: A total of 142 patients with cirrhosis who underwent saline-agitated contrast echocardiography were enrolled in this prospective observational study...
December 1, 2017: Digestive Diseases and Sciences
Khalil Eslamloo, Sabrina M Inkpen, Matthew L Rise, Rune Andreassen
MicroRNAs (miRNAs) are known to play important immunoregulatory roles in teleosts, although miRNAs involved in the antiviral immune response of Atlantic cod (Gadus morhua) were previously uncharacterised. Using deep sequencing and qPCR, the present study was conducted to identify miRNAs responsive to the viral mimic, polyriboinosinic polyribocytidylic acid (pIC) in Atlantic cod macrophages. Macrophage samples isolated from Atlantic cod (n=3) and treated with pIC or phosphate buffered saline (PBS control) for 24 and 72h were used for miRNA profiling...
November 27, 2017: Molecular Immunology
Seunghyi Kook, Aidong Qi, Ping Wang, Shufang Meng, Peter Gulleman, Lisa R Young, Susan H Guttentag
Defining the mechanisms of cellular pathogenesis for rare lung diseases such as Hermansky Pudlak syndrome (HPS) is often complicated by loss of the differentiated phenotype of cultured primary alveolar type 2 (AT2) cells, and by a lack of durable cell lines that are faithful to both AT2 cell and rare disease phenotypes. We used CRISPR/Cas9 gene editing to generate a series of HPS-specific mutations in the MLE-15 cell line. The resulting MLE-15/HPS cell lines exhibit preservation of AT2 cellular functions, including formation of lamellar body-like organelles, complete processing of Surfactant protein B (SP-B), and known features of HPS specific to each trafficking complex, including loss of protein targeting to lamellar bodies...
November 30, 2017: American Journal of Respiratory Cell and Molecular Biology
Satoshi Koizumi, Yumiko Yamaoka, Takeshi Matsuo, Toshikazu Kimura, Tomohiro Inoue
BACKGROUND: Hyperperfusion syndrome (HPS) is a well-known complication of carotid endarterectomy (CEA) warranting repeatable inexpensive monitoring. Transcranial color-coded sonography (TCCS) may provide a potential modality for such monitoring, but little is known about TCCS trends after CEA. METHODS: Between January 2016 and February 2017, we prospectively included patients with CEA at our institute in this study. TCCS was performed preoperatively and repeated daily from the operation day until postoperative day (POD) 7...
November 24, 2017: World Neurosurgery
Yong Hu, XiaoYong Wu, Xu JinRui
The supramolecular hydrogel based on inclusion complexation between PLA/CS diblock copolymer and β-CD has been demonstrated. The PLA/CS diblock copolymer confirmed by FIIR and 1HNMR were synthesized by in situ polymerization. The supramolecular hydrogel formed due to the complexation of PLA/CS with β-cyclodextrin was demonstrated by XRD and FIIR analysis. These results indicate that the carbonyl groups of PLA can form hydrogen bonds with the hydroxyl groups of β-CD and CS in the complexes. The supramolecular hydrogel presented a porous network structure observed by positive fluorescence microscopy (PFM) was found to be thixotropic and reversibl...
November 24, 2017: International Journal of Biological Macromolecules
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