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https://www.readbyqxmd.com/read/28535407/a-prospective-study-of-bipolar-disorder-vulnerability-in-relation-to-behavioural-activation-behavioural-inhibition-and-dysregulation-of-the-behavioural-activation-system
#1
R C Dempsey, P A Gooding, S H Jones
BACKGROUND: The weak regulation, or "dysregulation", of the Behavioural Activation System (BAS) is implicated in the development and recurrence of bipolar disorder. However, there has been a lack of prospective studies investigating the predictive role of BAS dysregulation in relation to bipolar-vulnerability. Furthermore, no studies have tested the prospective predictive utility of the DYS self-report measure of BAS dysregulation in an analogue sample. The goal of the current study was to redress this gap...
March 31, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28534409/dimensionality-and-interface-engineering-of-2d-homologous-perovskites-for-boosted-charge-carrier-transport-and-photodetection-performances
#2
Dejian Yu, Fei Cao, Yalong Shen, Xuhai Liu, Ying Zhu, Haibo Zeng
Two dimensional (2D) homologous halide perovskites (HPs) microcrystallines have emerged as promising alternative light-sensitive materials, however, the undesirable quantum confinement effect and severe interfacial charge carrier scattering still hamper their applications in photodetectors (PDs). Here we propose a novel post-synthetic treatment to simultaneously solve both problems. 2D (OA)2FAn-1PbnBr3n+1 (OA and FA represent octadecylamine and formamidine) microplatelets film was immersed into solution containing FA+, leading to improvements in two aspects...
May 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28532803/secondary-haemophilus-parasuis-infection-enhances-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus-hp-prrsv-infection-mediated-inflammatory-responses
#3
Jiangnan Li, Shengnan Wang, Changyao Li, Chunlai Wang, Yonggang Liu, Gang Wang, Xijun He, Liang Hu, Yuanyuan Liu, Mengmeng Cui, Caihong Bi, Zengyu Shao, Xiaojie Wang, Tao Xiong, Xuehui Cai, Li Huang, Changjiang Weng
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection often predisposes pigs to secondary bacterial infection, which induces robust inflammatory responses. However, whether the secondary bacterial infection synergizes HP-PRRSV infection and enhances inflammatory responses is not fully understood. Here, we characterized HP-PRRSV infection-mediated secondary bacterial infection and robust inflammatory responses. HP-PRRSV infection induced higher levels of cytokines (IL-1β, IL-18, IL-6 and TNF-α) in the sera in piglets and bacterial loads of 11 bacterial species in the lung were increased after HP-PRRSV infection, including Mycoplasma hyorhinis, Haemophilus parasuis and Escherichia coli...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28523579/primary-care-and-hepatology-provider-perceived-barriers-to-and-facilitators-of-hepatitis-c-treatment-candidacy-and-adherence
#4
Shari S Rogal, Rory McCarthy, Andrea Reid, Keri L Rodriguez, Linda Calgaro, Krupa Patel, Molly Daley, Naudia L Jonassaint, Susan L Zickmund
BACKGROUND: Provider perceptions regarding barriers to and facilitators of hepatitis C (HCV) treatment initiation and adherence have not been fully evaluated in the interferon-free treatment era. New treatments have provided opportunities for non-specialists to treat HCV, underscoring the importance of understanding primary care provider (PCP) and specialist perspectives. METHODS: Based on qualitative sampling principles, 12 PCPs and 12 hepatology providers (HPs) from the VA Pittsburgh Healthcare System completed audio-recorded semi-structured interviews...
May 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28515440/a-highly-potent-class-of-halogenated-phenazine-antibacterial-and-biofilm-eradicating-agents-accessed-through-a-modular-wohl-aue-synthesis
#5
Hongfen Yang, Yasmeen Abouelhassan, Gena M Burch, Dimitris Kallifidas, Guangtao Huang, Hussain Yousaf, Shouguang Jin, Hendrik Luesch, Robert W Huigens
Unlike individual, free-floating planktonic bacteria, biofilms are surface-attached communities of slow- or non-replicating bacteria encased within a protective extracellular polymeric matrix enabling persistent bacterial populations to tolerate high concentrations of antimicrobials. Our current antibacterial arsenal is composed of growth-inhibiting agents that target rapidly-dividing planktonic bacteria but not metabolically dormant biofilm cells. We report the first modular synthesis of a library of 20 halogenated phenazines (HP), utilizing the Wohl-Aue reaction, that targets both planktonic and biofilm cells...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28505281/application-of-partially-substituted-3-5-dimethylphenylcarbamate-3-2-o-%C3%AE-cyclodextrin-2-hydroxypropoxy-propylsilyl-appended-silica-particles-as-chiral-stationary-phase-for-multi-mode-high-performance-liquid-chromatography
#6
Mingxuan Ma, Qunli Wei, Min Meng, Jiale Yin, Lei Du, Xia Zhu, Mengjun Min, Xueyan Zhou, Xiaoxing Yin, Yinhan Gong
A new type of partially substituted 3,5-dimethylphenylcarbamate-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles (MP-CD-HPS) have been prepared by a convenient post-immobilization derivazition procedure. The MP-CD-HPS has been successfully used as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC) under normal phase, reversed phase and polar organic mobile phase conditions. The chromatographic evaluation results show that the MP-CD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of some chiral compounds...
May 13, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28504062/the-health-promoting-schools-framework-known-unknowns-and-an-agenda-for-future-research
#7
Rebecca Langford, Christopher Bonell, Kelli Komro, Simon Murphy, Daniel Magnus, Elizabeth Waters, Lisa Gibbs, Rona Campbell
The World Health Organization's Health Promoting Schools (HPS) framework is a whole-school approach to promoting health that recognizes the intrinsic relationship between health and education. Our recent Cochrane systematic review found HPS interventions produced improvements in a number of student health outcomes. Here we reflect on what this review was not able to tell us: in other words, what evidence is missing with regard to the HPS approach. Few HPS interventions engage with schools' "core business" by examining impacts on educational outcomes...
June 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28501592/endoscopic-and-molecular-characterization-of-colorectal-sessile-serrated-adenoma-polyps-with-cytological-dysplasia
#8
Yoshihito Tanaka, Hiro-O Yamano, Eiichiro Yamamoto, Hiro-O Matushita, Hironori Aoki, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Yuko Yoshida, Makoto Eizuka, Tamotsu Sugai, Hiromu Suzuki, Hiroshi Nakase
BACKGROUND AND AIMS: Sessile serrated adenoma/polyps (SSA/Ps), which are precursor lesions of colorectal cancer (CRC) with BRAF mutation and the CpG island methylator phenotype (CIMP), develop cytological dysplasia (CD) during the progression of colorectal tumorigenesis. In the present study, we aimed to clarify the endoscopic and molecular signatures of SSA/Ps, with and without CD. METHODS: A series of 208 serrated lesions, including 41 hyperplastic polyps (HPs), 90 SSA/Ps, 33 SSA/Ps with CD and 44 traditional serrated adenomas (TSAs), were observed and resected using magnifying endoscopy...
May 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28498060/correlation-between-reduction-in-microvascular-transit-time-after-superficial-temporal-artery-middle-cerebral-artery-bypass-surgery-for-moyamoya-disease-and-the-development-of-postoperative-hyperperfusion-syndrome
#9
Tao Yang, Yoshifumi Higashino, Hiroharu Kataoka, Eika Hamano, Daisuke Maruyama, Koji Iihara, Jun C Takahashi
OBJECTIVE Hyperperfusion syndrome (HPS) is a notable complication that causes various neurological symptoms after superficial temporal artery (STA)-middle cerebral artery (MCA) bypass surgery for moyamoya disease (MMD). The authors used intraoperative indocyanine green (ICG) videoangiography to measure the change in microvascular transit time (MVTT) after bypass surgery. An analysis was then conducted to identify the correlation between change in MVTT and presence of postoperative HPS. METHODS This study included 105 hemispheres of 81 patients with MMD who underwent STA-MCA single bypass surgery between January 2010 and January 2015...
May 12, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28497365/clinical-utility-of-soluble-interleukin-2-receptor-in-hemophagocytic-syndromes-a-systematic-scoping-review
#10
REVIEW
Molly Lin, Sujin Park, Anna Hayden, Dean Giustini, Martina Trinkaus, Morris Pudek, Andre Mattman, Marion Schneider, Luke Y C Chen
The serum-soluble interleukin-2 receptor (sIL-2r) level is considered an important diagnostic test and disease marker in hemophagocytic syndromes/hemophagocytic lymphohistiocytosis (HPS/HLH). However, this cytokine receptor is rarely measured in clinical practice and has been excluded from recent diagnostic/classification criteria such as the HScore and macrophage activation syndrome (MAS) 16. We performed a systematic scoping review of 64 articles (1975-2016) examining the clinical utility of sIL-2r in HPS/HLH...
May 12, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28494714/is-the-hepatic-factor-a-mirna-that-maintains-the-integrity-of-pulmonary-microvasculature-by-inhibiting-the-vascular-endothelial-growth-factor
#11
Joseph John Vettukattil
The "hepatic factor," a molecule or group of molecules present in the hepatic venous blood, essential for the prevention of the development of pulmonary arteriovenous malformations (PAVMs) and right-to-left shunting has been a conceptual enigma in the understanding of many related conditions. Patients with various forms of liver diseases including acute hepatic failure, and others with normal hepatic function like hereditary hemorrhagic telangiectasia (HHT), inflammatory and parasitic disorders, cardiogenic hepatopulmonary syndrome (cHPS) and skin disorders like Dyskeratosis congenita are all known to cause PAVMs...
May 9, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28490412/improving-community-access-to-terminal-phase-medicines-in-australia-identification-of-the-key-considerations-for-the-implementation-of-a-core-medicines-list
#12
Paul A Tait, Weng Hou Cheung, Michael Wiese, Kirsten Staff
During the terminal phase, access to medicines is critical for people wishing to spend their last days of life at home. Yet, access to medicines can be problematic. The aim of this study was to report the perspectives of specialist and generalist health professionals (HPs) on the issues of community access to medicines for this vulnerable group. A qualitative descriptive study design investigated the views of HPs working in palliative care roles in South Australia. Nurses, doctors and pharmacists described their experiences of accessing medicines for management of terminal phase symptoms during semi-structured focus group discussions...
May 11, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28489830/-clinical-and-laboratory-characteristics-of-patients-with-pulmonary-hypertension-and-pulmonary-vascular-complications-hospitalized-at-the-instituto-nacional-de-salud-del-ni%C3%A3-o
#13
Alexis Jose Ormeño Julca, Carlos Melchor Alvarez Murillo, Pedro Miguel Amoretti Alvino, Angel Aladino Florian Florian, Rosa Aurora Castro Johanson, Maria Danisa Celi Perez, Olga Rocío Huamán Prado
The hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPHN) are distinct pulmonary vascular complications of portal hypertension (PHT) and are associated with increased morbidity and mortality. OBJECTIVES: To describe the clinical and laboratory characteristics of patients with pulmonary hypertension and pulmonary vascular complications hospitalized at the Instituto Nacional de Salud del Niño. MATERIALS AND METHODS: We included patients with HTP hospitalized from January 2012 to June 2013 and that during its evolution progressed with SHP or HTPP...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28489771/chronic-active-epstein-barr-virus-infection-associated-with-hemophagocytic-syndrome-and-extra-nodal-natural-killer-t-cell-lymphoma-in-an-18-year-old-girl-a-case-report
#14
Yawei Xing, Junwen Yang, Guanghui Lian, Shuijiao Chen, Linlin Chen, Fujun Li
RATIONALE: Chronic active Epstein-Barr virus infection (CAEBV) associated with hemophagocytic syndrome (HPS) and extra-nodal natural killer (NK)/T-cell lymphoma (ENKL) is a rare life-threatening disorder. This disease is easily misdiagnosed because of its varied presentations. PATIENT CONCERNS: An 18-year-old girl was admitted to our hospital with a history of edema in the lower limbs and intermittent fever lasting for more than 1 month. At admission, she had severe liver injury of unknown etiology...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28480722/hepatopulmonary-syndrome-with-large-pulmonary-arteriovenous-malformations-ct-findings-with-emphasis-on-its-association-with-a-mosaic-pattern-of-the-lung-parenchyma
#15
Luis Gorospe Sarasúa, Andreína Olavarría-Delgado, Frank Eric Farfán-Leal, Josefa Pérez-Templado Ladrón de Guevara
We present a case of a 54-year-old patient with cirrhosis, progressive dyspnea, and platypnea. Thoracic computed tomography (CT) showed multiple pulmonary arteriovenous malformations (PAVM), confirming the diagnosis of hepatopulmonary syndrome (HPS). Besides precisely identifying the number and location of PAVM, CT also demonstrated a striking mosaic pattern of the lung parenchyma, characterized by the presence of alternating geographic areas of low attenuation (showing pulmonary vessels with a decreased diameter) with regions of relatively increased attenuation (showing pulmonary vessels with a normal diameter)...
May 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28471015/5-hetero-aryl-substituted-9-hydroxyphenalenones-synthesis-and-electronic-properties-of-multifunctional-donor-acceptor-conjugates
#16
Thomas J J Müller, Lisa Bensch, Irina Gruber, Christoph Janiak
5-(Hetero)aryl substituted 9-hydroxyphenalenones (9-HP) can be readily synthesized by Suzuki coupling of 5-bromo 9-HP with (hetero)aryl boronic acid (derivatives) void of protection of the hydroxyl functionality with moderate to excellent yields (57-94%). A library of 5-(hetero)aryl substituted 9-HP with broad substituent variation was studied with respect to their electronic properties (absorption and emission spectroscopy, cyclic voltammetry) and their computed electronic structure. All compounds show reversible reductive potentials between -1230 and -1110 mV and the donor-substituted representatives possess irreversible oxidation potentials around 600 mV...
May 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28469575/honokiol-alleviates-hypertrophic-scar-by-targeting-transforming-growth-factor-%C3%AE-smad2-3-signaling-pathway
#17
Danyang Zhao, Yu Wang, Chao Du, Shengzhou Shan, Yifan Zhang, Zijing Du, Dong Han
Hypertrophic scar (HPS) presents as excessive extracellular matrix deposition and abnormal function of fibroblasts. However, there is no single satisfactory method to prevent HPS formation so far. Here, we found that honokiol (HKL), a natural compound isolated from Magnolia tree, had an inhibitory effect on HPS both in vitro and in vivo. Firstly, HKL could dose-dependently down-regulate the mRNA and protein levels of type I collagen, type III collagen, and α-smooth muscle actin (α-SMA) in hypertrophic scar-derived fibroblasts (HSFs)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28457061/association-between-fatty-liver-disease-and-hyperplastic-colonic-polyp
#18
Mahmud Mahamid, Tarik Yassin, Omar Abu Elheja, William Nseir
BACKGROUND: Hyperplastic polyps (HPs) of the colon are the most common colorectal polyps. Metabolic syndrome components such as obesity and hyperlipidemia are considered the most common etiological factors for HPs as well contributing to the pathogenesis of fatty liver disease. OBJECTIVES: To determine the possible association between biopsy-proven steatohepatitis and hyperplastic colonic polyps. METHODS: This retrospective cohort observational study conducted at the Holy Family Hospital in Nazareth, Israel, included subjects who underwent screening colonoscopy over a 2 year period...
February 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28457018/modulation-of-the-n400-component-in-relation-to-hypomanic-personality-traits-in-a-word-meaning-ambiguity-resolution-task
#19
Delphine Raucher-Chéné, Sarah Terrien, Pamela Gobin, Fabien Gierski, Arthur Kaladjian, Chrystel Besche-Richard
AIM: High levels of hypomanic personality traits have been associated with an increased risk of developing bipolar disorder (BD). Changes in semantic content, impaired verbal associations, abnormal prosody and abnormal speed of language are core features of BD, and are thought to be related to semantic processing abnormalities. In the present study, we used event-related potentials to investigate the relationship between semantic processing (N400 component) and hypomanic personality traits...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28445466/human-pluripotent-stem-cells-recurrently-acquire-and-expand-dominant-negative-p53-mutations
#20
Florian T Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A McCarroll, Kevin Eggan
Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with a growth advantage in culture. The nature, extent and functional effects of other acquired genome sequence mutations in cultured hPS cells are not known. Here we sequence the protein-coding genes (exomes) of 140 independent human embryonic stem cell (hES cell) lines, including 26 lines prepared for potential clinical use...
May 11, 2017: Nature
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