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Flávio D Fuchs, Sandra C Fuchs, Carlos E Poli-de-Figueiredo, José A Figueiredo Neto, Luiz César N Scala, José F Vilela-Martin, Leila B Moreira, Hilton Chaves, Marco Mota Gomes, Marcos R de Sousa, Ricardo Pereira E Silva, Iran Castro, Evandro José Cesarino, Ana Luiza Lima Sousa, João Guilherme Alves, André Avelino Steffens, Andréa Araujo Brandão, Luiz Aparecido Bortolotto, Abrahão Afiune Neto, Antônio C Nóbrega, Roberto Silva Franco, Dario C Sobral Filho, Fernando Nobre, Rosane Schlatter, Miguel Gus, Caroline Nespolo De David, Leticia Rafaelli, Guilhermo Prates Sesin, Otávio Berwanger, Paul K Whelton
BACKGROUND: To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension. METHODS: The PREVER-prevention trial was a randomized, parallel, double-blinded, placebo-controlled trial, with 18 months of follow-up, conducted at 21 academic medical centers in Brazil. Of 1772 individuals evaluated for eligibility, 730 volunteers with prehypertension who were aged 30-70 years, and who did not reach optimal blood pressure after 3 months of lifestyle intervention, were randomized to a fixed association of chlorthalidone 12...
December 7, 2017: Journal of Hypertension
D Rose Ewald, Sarah Howle Bond, Lauren A Haldeman
Disadvantaged adolescents are at higher risk for undiagnosed and untreated obesity and hypertension. Using nurse-measured weight, height, and blood pressure (BP) as well as self-reported age and activity/lifestyle behaviors, we assessed the prevalence of obesity and hypertension in 573 adolescent patients aged 13.0 to 17.9 years (females: n = 267, 46.6%; males: n = 306, 53.4%) from a clinic serving low-income, ethnically diverse pediatric patients. Body mass index distribution was as follows: 11, underweight (1...
2017: Global Pediatric Health
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels...
December 4, 2017: Hypertension
Yi-Bang Cheng, Yan Li
No abstract text is available yet for this article.
December 4, 2017: Hypertension
Mandeep Singh, Atul Kotwal, Chetan Mittal, S Ram Babu, Sahul Bharti, C Venkata S Ram
While elevated blood pressure is a recognized risk factor for cardiovascular disease, the prevalence of hypertension still remains unclear for most populations. A door-to-door survey was conducted using modified WHO STEPS questionnaire in a group of villages under the Thavanampalle Mandal of Chittoor District in the state of Andhra Pradesh of South India. Data were collated and analyzed for 16,636 individuals (62.3% females and 37.7% males) above 15 years of age. Overall, prevalence of hypertension (as per JNC-7 classification) was found to be 27...
November 27, 2017: Journal of Human Hypertension
Dian He, Shaowen Wu, Haiping Zhao, Zihe Zheng, Weiyuan Zhang
OBJECTIVE: This study was to evaluate effects of high normal blood pressure (HNBP) in early pregnancy on total preeclampsia, early preeclampsia, and severe preeclampsia. METHODS: We conducted a multicenter, national representative retrospective cohort study. HNBP was defined as systolic blood pressure between 130 and 140 mmHg or diastolic blood pressure between 85 and 90 mmHg. We used multivariable logistic regression to examine the associations of HNBP and the risks of above three types of preeclampsia...
November 27, 2017: Clinical and Experimental Hypertension: CHE
F Kristek, M Drobna, S Cacanyiova
Structural changes of thoracic aorta (TA), carotid (CA) and iliac artery (IA) were assessed in Wistar and spontaneously hypertensive rats (SHR) aged 3, 17, and 52 weeks. Systolic blood pressure (sBP) was measured by plethysmography weekly. After perfusion fixation the arteries were processed for electron microscopy. The wall thickness (WT), cross-sectional area (CSA), inner diameter (ID), and WT/ID in all arteries and volume densities of endothelial cells (ECs), muscle cells (SMCs), and extracellular matrix (ECM) in TA were measured and their CSAs were calculated...
November 24, 2017: Physiological Research
Todd M Gibson, Zhenghong Li, Daniel M Green, Gregory T Armstrong, Daniel A Mulrooney, DeoKumar Srivastava, Nickhill Bhakta, Kirsten K Ness, Melissa M Hudson, Leslie L Robison
Background: Hypertension potentiates cardiovascular risk in survivors of childhood cancer previously exposed to cardiotoxic therapies, so it is important to determine the prevalence and risk factors for hypertensive blood pressure in this high-risk group.Methods: Participants included 3,016 adult 10-year survivors of childhood cancer who had resting blood pressure measurements performed at St. Jude Children's Research Hospital (Memphis, TN). We characterized the blood pressure status of participants, calculated standardized prevalence ratios based on U...
November 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
Yang Shen, Chun Chang, Jingru Zhang, Ying Jiang, Bingying Ni, Yanling Wang
BACKGROUND: Little information is available on the epidemiology of hypertension and prehypertension at high altitude in China, the aim of this study was to determine the prevalence of hypertension, prehypertension and their risk factors among Chinese working population at high altitude regions. METHODS: A cross-sectional survey was performed in an occupational sample of 4198 employees aged 20-59 years on Qinghai-Tibet Plateau between May to July 2013. Information from a self-administered questionnaire, physical examinations and laboratory measurements were obtained from each participant...
April 4, 2017: Environmental Health and Preventive Medicine
Edna Magaly Gamboa Delgado, Yully Andrea Rangel-Díaz, Yareni Yunuen Gutiérrez-Gómez
BACKGROUND: Birth weight could be a medium-term risk factor in the development of overweight and obesity and a long-term risk factor of cardio-metabolic diseases. OBJECTIVE: To evaluate the association between birth weight and cardio-metabolic risk factors in children from Bucaramanga, Colombia. METHODS: This cross-sectional study included 1,282 children between five and eleven years of age in Bucaramanga. Dependent variables: arterial hypertension, arterial prehypertension, overweight/obesity, glucose intolerance, insulin resistance, dyslipidemia...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Meenakshi Shukla, Rakesh Pandey, Dharmendra Jain, Jennifer Y F Lau
Psychological factors are known to play an important part in the origin of many medical conditions including hypertension. Recent studies have reported elevated blood pressure (even in the normal range of variation) to be associated with a reduced responsiveness to emotions or 'emotional dampening'. Our aim was to assess emotional dampening in individuals with more extreme blood pressure levels including prehypertensives (N=58) and hypertensives (N=60) by comparing their emotion recognition ability with normotensives (N=57)...
November 12, 2017: Psychology & Health
Yingshui Yao, Lijun Zhu, Zhengmei Fang, Song Yang, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Hailong Zhao, Qian Zhuang, Xiaotian Chen, Chong Shen
BACKGROUND: Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) have been suggested to mediate the pathophysiological response to elevated blood pressure. This study aims to evaluate the association of IGF-1 and IGF-1R with hypertension. METHODS: Overall, 2012 hypertensive cases and 2210 controls were included in a case-control study, and ten tagSNPs were selected. The association of these SNPs with hypertension was further evaluated in a follow-up analysis and in an adolescent population...
November 6, 2017: American Journal of Hypertension
Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza
BACKGROUND: Vascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND RESULTS: Forty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo...
November 9, 2017: Journal of the American Heart Association
Guilherme F Fonseca, Paulo T V Farinatti, Adrian W Midgley, Arthur Ferreira, Tainah de Paula, Walace D Monteiro, Felipe A Cunha
Fonseca, GF, Farinatti, PTV, Midgley, AW, Ferreira, A, de Paula, T, Monteiro, WD, and Cunha, FA. Continuous and accumulated bouts of cycling matched by intensity and energy expenditure elicit similar acute blood pressure reductions in prehypertensive men. J Strength Cond Res XX(X): 000-000, 2017-This study investigated differences in postexercise hypotension (PEH) after continuous vs. accumulated isocaloric bouts of cycling. Ten prehypertensive men, aged 23-34 years, performed 2 bouts of cycling at 75% oxygen uptake reserve, with total energy expenditures of 400 kcal per bout...
November 6, 2017: Journal of Strength and Conditioning Research
Emer R McGrath, Alexa S Beiser, Charles DeCarli, Kendra L Plourde, Ramachandran S Vasan, Steven M Greenberg, Sudha Seshadri
OBJECTIVE: To determine the association between blood pressure during midlife (40-64 years) to late life (≥65 years) and risk of incident dementia. METHODS: This study included 1,440 (758 women, mean age 69 ± 6 years) Framingham Offspring participants who were free of dementia and attended 5 consecutive examinations at 4-year intervals starting at midlife (1983-1987, mean age 55 years) until late life (1998-2001, mean 69 years) and subsequently were followed up for incident dementia (mean 8 years)...
November 8, 2017: Neurology
Piyanuch Thitiwuthikiat, Duangduan Siriwittayawan, Teonchit Nuamchit
Prehypertension and serum uric acid are emerging as independent risk factors for arterial stiffness and may also predict cardiovascular diseases. Previous studies have demonstrated the association between serum uric acid and arterial stiffness in hypertensive adults, but there are limited studies in prehypertensive adults. We compared the serum uric acid (SUA) and cardio-ankle vascular index (CAVI) between normotensive and prehypertensive participants. The association between SUA, prehypertension and CAVI were investigated...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
Chukwunonso E C C Ejike, Patricia O Ukegbu
Obesity is known to correlate with measures of blood pressure (BP). The nature of the correlations has, however, remained a subject of scientific enquiry, especially when BP phenotypes are disaggregated and obesity is determined by a variety of methods. This study examined the relationship between obesity and BP in young-adult Nigerians. A total of 1610 subjects (53.9% females) were recruited from five universities in the Igbo-speaking part of Nigeria. Relevant BP and anthropometric data were obtained following standard protocols...
May 12, 2017: Medical Sciences: Open Access Journal
Vanessa Moraes Bezerra, Amanda Cristina de Souza Andrade, Danielle Souto de Medeiros, Waleska Teixeira Caiaffa
Arterial prehypertension is a precursor of arterial hypertension and a risk factor for cardiovascular diseases. Vulnerable populations are more prone to this condition due to difficulties in access to health services. A previous study in quilombola communities (descendants of African slaves) reported a high prevalence of arterial hypertension. The current study aimed to estimate the prevalence of arterial prehypertension in quilombolas and to assess associated factors. This was a cross-sectional population-based study in individuals 18 years and older...
October 26, 2017: Cadernos de Saúde Pública
Dongdong Sun, Jielin Liu, Lei Xiao, Ya Liu, Zuoguang Wang, Chuang Li, Yongxin Jin, Qiong Zhao, Shaojun Wen
BACKGROUND: Hypertension is a leading global health threat and a major cardiovascular disease. Since clinical interventions are effective in delaying the disease progression from prehypertension to hypertension, diagnostic prediction models to identify patient populations at high risk for hypertension are imperative. METHODS: Both PubMed and Embase databases were searched for eligible reports of either prediction models or risk scores of hypertension. The study data were collected, including risk factors, statistic methods, characteristics of study design and participants, performance measurement, etc...
2017: PloS One
Cindy George, Amelie Mogueo, Ikechi Okpechi, Justin B Echouffo-Tcheugui, Andre Pascal Kengne
Chronic kidney disease (CKD) is fast becoming a major public health issue, disproportionately burdening low-income to middle-income countries, where detection rates remain low. We critically assessed the extant literature on CKD screening in low-income to middle-income countries. We performed a PubMed search, up to September 2016, for studies on CKD screening in low-income to middle-income countries. Relevant studies were summarised through key questions derived from the Wilson and Jungner criteria. We found that low-income to middle-income countries are ill-equipped to deal with the devastating consequences of CKD, particularly the late stages of the disease...
2017: BMJ Global Health
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