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Prehypertension

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https://www.readbyqxmd.com/read/28106664/ethnic-differences-regarding-arterial-stiffness-of-6-8-year-old-black-and-white-boys
#1
Gontse G Mokwatsi, Aletta E Schutte, Ruan Kruger
OBJECTIVES: Vascular deterioration is suggested to occur earlier in black than white populations, thereby increasing their risk for developing hypertension. To establish whether this is the case, we compared different estimates of arterial stiffness in black and white children and investigated the links with body composition and advanced glycation end products (AGEs) as potential contributors. METHODS: We included 40 black and 41 white boys (aged 6-8 years) from similar schools and measured arterial stiffness [pulse wave velocity (PWV) in different arterial sections, systemic arterial compliance and carotid stiffness estimates], anthropometry as well as urinary pentosidine as a marker of AGEs...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28100465/prevalence-of-masked-hypertension-among-us-adults-with-nonelevated-clinic-blood-pressure
#2
Y Claire Wang, Daichi Shimbo, Paul Muntner, Andrew E Moran, Lawrence R Krakoff, Joseph E Schwartz
Masked hypertension (MHT), defined as nonelevated blood pressure (BP) in the clinic setting and elevated BP assessed by ambulatory monitoring, is associated with increased risk of target organ damage, cardiovascular disease, and mortality. Currently, no estimate of MHT prevalence exists for the general US population. After pooling data from the Masked Hypertension Study (n = 811), a cross-sectional clinical investigation of systematic differences between clinic BP and ambulatory BP (ABP) in a community sample of employed adults in the New York City metropolitan area (2005-2012), and the National Health and Nutrition Examination Survey (NHANES; 2005-2010; n = 9,316), an ongoing nationally representative US survey, we used multiple imputation to impute ABP-defined hypertension status for NHANES participants and estimate MHT prevalence among the 139 million US adults with nonelevated clinic BP, no history of overt cardiovascular disease, and no use of antihypertensive medication...
January 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28095471/prevalence-and-risk-factors-of-prehypertension-and-hypertension-in-southern-china
#3
Lihua Hu, Xiao Huang, Chunjiao You, Juxiang Li, Kui Hong, Ping Li, Yanqing Wu, Qinhua Wu, Huihui Bao, Xiaoshu Cheng
BACKGROUND: This study aimed to describe the prevalence and risk factors of prehypertension and hypertension in Jiangxi Province, China. Individuals with prehypertension frequently progress into hypertension and are at high risk of developing cardiovascular disease and stroke. METHODS: A cross-sectional survey of 15,296 participants (15 years or older) was conducted in Jiangxi Province, China, in 2013, using questionnaire forms and physical measurements. RESULTS: The prevalence of prehypertension and hypertension was 32...
2017: PloS One
https://www.readbyqxmd.com/read/28074637/moderately-elevated-blood-pressure-during-pregnancy-and-odds-of-hypertension-later-in-life-the-pouchmoms-longitudinal-study
#4
Galit Levi Dunietz, Kelly L Strutz, Claudia Holzman, Yan Tian, David Todem, Bertha L Bullen, Janet M Catov
OBJECTIVE: Hypertensive disorders in pregnancy signal an increased risk of cardiovascular disease for women. However, future hypertension risk among pregnant women with moderately elevated blood pressure (BP) is unknown. We examined associations among moderately elevated BP or hypertensive disorders during pregnancy and later prehypertension or hypertension. DESIGN: Longitudinal cohort study. SETTING: Five communities in Michigan, USA. SAMPLE: Data are from pregnant women enrolled in the Pregnancy Outcomes and Community Health Study...
January 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28055286/elevated-serum-complement-c3-levels-are-associated-with-prehypertension-in-an-adult-population
#5
Xue Bao, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Huanmin Du, Hongbin Shi, Yang Xia, Xiaoyan Guo, Xing Liu, Peipei Han, Renwei Dong, Xiuyang Wang, Chunlei Li, Qian Su, Yeqing Gu, Liyun Fang, Fei Yu, Huijun Yang, Li Kang, Yixuan Ma, Bin Yu, Xinyu Ma, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Qi Guo, Kun Song, GuoLin Wang, Guowei Huang, Kaijun Niu
Prehypertension is a public health epidemic associated with various adverse outcomes, but can be reversed by timely intervention. However, little attention has been paid to prehypertension. Complement C3 is a central hub of complement-related immune system. We examined the association between C3 and prehypertension in an adult population for the first time, aiming to investigate whether pro-inflammatory immune response is involved in the prehypertensive state. About 7820 Tianjin residents without hypertension were categorized into sex-specific quintiles based on their serum concentration of complement C3...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28008265/prevalence-of-cardiovascular-risk-factors-among-workers-at-a-private-tertiary-center-in-angola
#6
Feliciano Chanana Paquissi, Valdano Manuel, Ana Manuel, Guiomar Lote Mateus, Bruna David, Gertrudes Béu, Anselmo Castela
BACKGROUND: The burden of cardiovascular diseases (CVD) is increasing in most countries of sub-Saharan Africa. However, as there is a scarcity of data, little is known about CVD in Angola. This study aimed to determine the prevalence of prehypertension, hypertension, prediabetes, diabetes, overweight, and obesity among workers at a private tertiary center in Angola. METHODS: A cross-sectional study was conducted among 781 workers of Clínica Girassol, a tertiary health care center in Angola, during the month of November 2013...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28000857/hypomethylation-of-agtrap-is-associated-with-long-term-inhibition-of-left-ventricular-hypertrophy-in-prehypertensive-losartan-treated-spontaneously-hypertensive-rats
#7
Ting-Jun Wang, Gui-Li Lian, Xu Lin, Hong-Bin Zhong, Chang-Sheng Xu, Hua-Jun Wang, Liang-Di Xie
Prehypertensive losartan treatment may lead to long‑term inhibition of the development of left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs). However, the underlying mechanism has yet to be fully elucidated. The aim of the present study was to investigate the expression of angiotensin type 1 receptor-associated protein (ATRAP/Agtrap) and methylation of the Agtrap gene in the myocardium following the withdrawal of treatment. Four‑week‑old SHRs were randomly divided into three groups, and were treated with saline, amlodipine or losartan, respectively, for 6 weeks...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27965209/effectiveness-of-chlorthalidone-plus-amiloride-for-the-prevention-of-hypertension-the-prever-prevention-randomized-clinical-trial
#8
Sandra Costa Fuchs, Carlos E Poli-de-Figueiredo, José A Figueiredo Neto, Luiz César N Scala, Paul K Whelton, Francisca Mosele, Renato Bandeira de Mello, José F Vilela-Martin, Leila B Moreira, Hilton Chaves, Marco Mota Gomes, Marcos R de Sousa, Ricardo Pereira E Silva, Iran Castro, Evandro José Cesarino, Paulo Cesar Jardim, João Guilherme Alves, André Avelino Steffens, Andréa Araujo Brandão, Fernanda M Consolim-Colombo, Paulo Ricardo de Alencastro, Abrahão Afiune Neto, Antônio C Nóbrega, Roberto Silva Franco, Dario C Sobral Filho, Alexandro Bordignon, Fernando Nobre, Rosane Schlatter, Miguel Gus, Felipe C Fuchs, Otávio Berwanger, Flávio D Fuchs
BACKGROUND: Prehypertension is associated with higher cardiovascular risk, target organ damage, and incidence of hypertension. The Prevention of Hypertension in Patients with PreHypertension (PREVER-Prevention) trial aimed to evaluate the efficacy and safety of a low-dose diuretic for the prevention of hypertension and end-organ damage. METHODS AND RESULTS: This randomized, parallel, double-blind, placebo-controlled trial was conducted in 21 Brazilian academic medical centers...
December 13, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27959909/former-very-preterm-infants-show-an-unfavorable-cardiovascular-risk-profile-at-a-preschool-age
#9
Anna Posod, Irena Odri Komazec, Katrin Kager, Ulrike Pupp Peglow, Elke Griesmaier, Elisabeth Schermer, Philipp Würtinger, Daniela Baumgartner, Ursula Kiechl-Kohlendorfer
Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile of former preterm infants in adolescence and adulthood. The aim of this study was to determine whether cardiovascular risk predictors are detectable in former very preterm infants at a preschool age. Five- to seven-year-old children born at <32 weeks' gestational age were included in the study. Same-aged children born at term served as controls. Basic data of study participants were collected by means of follow-up databases and standardized questionnaires...
2016: PloS One
https://www.readbyqxmd.com/read/27940711/diagnosis-and-medication-treatment-of-pediatric-hypertension-a-retrospective-cohort-study
#10
David C Kaelber, Weiwei Liu, Michelle Ross, A Russell Localio, Janeen B Leon, Wilson D Pace, Richard C Wasserman, Alexander G Fiks
BACKGROUND AND OBJECTIVES: Pediatric hypertension predisposes children to adult hypertension and early markers of cardiovascular disease. No large-scale studies have examined diagnosis and initial medication management of pediatric hypertension and prehypertension. The objective of this study was to evaluate diagnosis and initial medication management of pediatric hypertension and prehypertension in primary care. METHODS: Retrospective cohort study aggregating electronic health record data on >1...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27912212/knockdown-of-inhibitory-guanine-nucleotide-binding-protein-gi%C3%AE-2-by-antisense-oligodeoxynucleotides-attenuates-the-development-of-hypertension-and-tachycardia-in-spontaneously-hypertensive-rats
#11
Yousra Ali El-Basyuni, Yuan Li, Madhu B Anand-Srivastava
BACKGROUND: We previously showed that the levels of both Giα-2 and Giα-3 proteins were augmented in spontaneously hypertensive rats (SHRs) before the onset of hypertension. In addition, intraperitoneal injection of pertussis toxin, which inactivates both Giα proteins, prevented the development of hypertension in SHRs. The aim of the present study was to determine the specific contributions of Giα-2 and Giα-3 proteins to the development of hypertension. METHODS AND RESULTS: Antisense oligodeoxynucleotide of Giα-2 and Giα-3 encapsulated in PEG/DOTAP/DOPE cationic liposomes were administrated intravenously into 3-week-old prehypertensive SHRs and Wistar Kyoto rats, whereas the control Wistar Kyoto rats and SHRs received PBS, empty liposomes, or sense...
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27903995/prevalence-of-hypertension-and-obesity-related-hypertension-in-urban-school-aged-children-in-rasht
#12
Hamidreza Badeli, Amir Hassankhani, Zahra Naeemi, Sahar Hosseinzadeh, Shima Mehrabi, Motahhareh Pourkarimi, Sajjad Hosseini, Pourya Rahbar Nikoukar, Reza Nezamdoust, Alireza Rahimi, Asemeh Pourrajabi
INTRODUCTION: Hypertension is a worldwide health concern. Complications of hypertension not only affect adult patients, but also involve children. Given the importance of assessing children with hypertension in order to decrease adulthood complications, we aimed to assess the prevalence of hypertension in urban school-aged children in Rasht, Iran. MATERIALS AND METHODS: This cross-sectional study was conducted on 2072 school-aged children in Rasht, Iran, from January 2013 to December 2015...
November 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27863831/therapy-of-treatment-related-hypertension-in-metastatic-renal-cell-cancer-patients-receiving-sunitinib
#13
Philipp Ivanyi, Gernot Beutel, Nicole Drewes, Jens Pirr, Jan T Kielstein, Michael Morgan, Arnold Ganser, Viktor Grünwald
INTRODUCTION: Treatment-related hypertension (tHTN) is frequent during sunitinib treatment. However, data on risk factors and treatment of tHTN remain scarce. PATIENTS AND METHODS: Patients with metastatic renal-cell carcinoma treated with sunitinib from June 2004 to December 2011 were included. Medical records were retrospectively analyzed for tHTN risk factors and antihypertensive treatments (AHT). Descriptive statistics, Cox regression, and competitive risk models were applied...
October 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27861249/the-antihypertensive-effects-of-aerobic-versus-isometric-handgrip-resistance-exercise
#14
Garrett I Ash, Beth A Taylor, Paul D Thompson, Hayley V MacDonald, Lauren Lamberti, Ming-Hui Chen, Paulo Farinatti, William J Kraemer, Gregory A Panza, Amanda L Zaleski, Ved Deshpande, Kevin D Ballard, Mohammadtokir Mujtaba, C Michael White, Linda S Pescatello
BACKGROUND: Aerobic exercise reduces blood pressure (BP) on average 5-7 mmHg among those with hypertension; limited evidence suggests similar or even greater BP benefits may result from isometric handgrip (IHG) resistance exercise. METHOD: We conducted a randomized controlled trial investigating the antihypertensive effects of an acute bout of aerobic compared with IHG exercise in the same individuals. Middle-aged adults (n = 27) with prehypertension and obesity randomly completed three experiments: aerobic (60% peak oxygen uptake, 30 min); IHG (30% maximum voluntary contraction, 4 × 2 min bilateral); and nonexercise control...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27843840/blood-pressure-reduction-following-accumulated-physical-activity-in-prehypertensive
#15
Yogesh Saxena, Rani Gupta, Arsalan Moinuddin, Ravinder Narwal
CONTEXT: Accumulated moderate physical activity (PA) for 30 min in a day is the only recommended treatment of prehypertension. OBJECTIVE: We investigated autonomic modulation as a possible mechanism for the decrease in blood pressure (BP) during the rest periods in each 10 min session of PA. DESIGN SETTING AND PARTICIPANTS: We conducted a single-blind randomized multi-arm control trial on 40 prehypertensive (pre-HT) young male adults. METHODS: Participants were randomly divided by using random number table into four groups...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843053/prehypertension-is-associated-with-early-complications-of-atherosclerosis-but-not-with-exercise-capacity
#16
Mi-Hyang Jung, Sang-Hyun Ihm, Dong-Hyeon Lee, Woo-Baek Chung, Hae Ok Jung, Ho-Joong Youn
BACKGROUND: Prehypertension has a high risk of progression to hypertension, and intensive lifestyle modification including regular exercise is recommended for the management of prehypertensive individuals. However, data on the association between exercise capacity and hypertension status are limited. Therefore, we aimed 1) to define the characteristics of prehypertension, focusing on metabolic aspects and exercise capacity, and 2) to elucidate determinants of exercise capacity in healthy individuals without hypertension...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27836914/masked-hypertension-understanding-its-complexity
#17
REVIEW
Stanley S Franklin, Eoin O'Brien, Jan A Staessen
Masked hypertension, which is present when in-office normotension translates to out-of-office hypertension, is present in a surprisingly high percentage of untreated persons and an even higher percentage of patients after beginning antihypertensive medication. Not only are persons with prehypertension more likely to have masked hypertension than those with optimal blood pressure (BP), but also they frequently develop target organ damage prior to transitioning to sustained hypertension. Furthermore, the frequency of masked hypertension is high in individuals of African inheritance and in the presence of increased cardiovascular risk factors and disease states, such as diabetes and chronic renal failure...
November 10, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27824679/blood-pressure-and-left-ventricular-mass-index-in-healthy-adolescents
#18
Usama A Daimee, Marc B Lande, Wan Tang, Xin M Tu, Peter Veazie, John D Bisognano, Robert Block, John C Teeters
Primary hypertension among children and adolescents is increasing in prevalence and has been associated with the sequela of left ventricular hypertrophy (LVH), defined by increased left ventricular mass index (LVMI). The association between high blood pressure (BP) and LVMI in an otherwise healthy pediatric population is not well understood. We evaluated the relationship between measures of BP and LVMI in a group of healthy adolescents. We conducted a retrospective review of 55 high school athletes who participated in a community health screen, which included collecting BP readings and limited echocardiograms...
November 7, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27804962/alcohol-consumption-and-the-risk-for-renal-hyperfiltration-in-the-general-chinese-population
#19
M Lin, Q Su, H Huang, Y Zheng, J Wen, J Yao, J Liang, L Li, W Lin, L Lin, J Lu, Y Bi, W Wang, G Ning, G Chen
BACKGROUND/OBJECTIVES: Glomerular hyperfiltration has been considered an early marker of kidney injury in prediabetes and prehypertension. Heavy alcohol consumption remains highly prevalent and is considered a major public health problem worldwide. The degree of glomerular hyperfiltration associated with alcohol consumption remains unclear. SUBJECTS/METHODS: This study was conducted in three communities in China. A total of 15 390 participants (5396 males and 9994 females) aged 40-65 years were included in the study...
November 2, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27804179/pre-eclampsia-an-important-risk-factor-for-asymptomatic-heart-failure
#20
C Ghossein-Doha, J van Neer, B Wissink, N M Breetveld, L J de Windt, A P J van Dijk, M J van der Vlugt, M C H Janssen, W M Heidema, R R Scholten, M E A Spaanderman
OBJECTIVES: Pre-eclampsia (PE) is associated with both postpartum structural asymptomatic heart disease (i.e. heart failure Stage B (HF-B)) and conventional cardiovascular (CV) risk factors. We aimed to evaluate the extent to which PE, adjusted for conventional CV risk factors, is associated independently with asymptomatic cardiac abnormalities postpartum. METHODS: In this cross-sectional cohort study, 107 formerly pre-eclamptic women and 41 women with uneventful previous pregnancy (controls) were invited for CV risk assessment 4-10 years postpartum...
January 2017: Ultrasound in Obstetrics & Gynecology
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