Christina Karantanou, Valentina R Minciacchi, Rahul Kumar, Costanza Zanetti, Jimena Bravo, Raquel S Pereira, Georg Tascher, Tobias Tertel, Adriana Covarrubias-Pinto, Katrin Bankov, Lisa-Marie Pfeffermann, Halvard Bonig, Paola Divieti-Pajevic, David G McEwan, Bernd Giebel, Christian Münch, Ivan Dikic, Daniela S Krause
Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment (BMM), rendering it hospitable to leukemia cell survival, for instance by release of small extracellular vesicles (sEV). In converse, we show here, that BMM-deficiency of pleckstrin homology domain family M member 1 (PLEKHM1), which serves as a hub between fusion and secretion of intracellular vesicles and is important for vesicular secretion in osteoclasts, accelerates murine BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL) via regulation of the cargo of sEV released by BMM-derived mesenchymal stromal cells (MSC)...
August 31, 2022: Blood Advances