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BCG disemination

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https://www.readbyqxmd.com/read/178234/immunotherapy-of-malignancies-current-status
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F R Eilber, E C Holmes, D L Morton, K P Ramming, F C Sparks
The results of various in vitro analyses indicate there is an active immune response against antigens associated with human malignancies. This immune response apparently can be augmented by nonspecific immunologic stimulates such as BCG. These agents are effective for destroying tumor when injected locally into intracutaneous disease but are not as effective for subcutaneous disease. Preliminary clinical trials indicated that immune stimulants are effective when administered systemically. The effect is only minimal for diseminated disease, but the therapeutic benefit is clearly augmented for patients with a minimal residual tumor burden, such as those patients with metastases to regional lymph nodes...
May 1976: AJR. American Journal of Roentgenology
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