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heated intraperitoneal chemotherapy

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https://www.readbyqxmd.com/read/28772202/the-role-of-surgical-excision-for-the-krukenberg-tumour-a-case-report
#1
David Lam, Eugene Ong
INTRODUCTION: Krukenberg tumour (KT), which represents carcinoma in the ovary, is an uncommon manifestation of metastatic colorectal cancer. It is associated with poor prognosis and a high incidence of peritoneal metastatic disease. PRESENTATION OF CASE: The authors present a case of a 51-year-old female who had a symptomatic, metachronous right ovarian KT diagnosed 12 months after her initial resection. Surgery was performed to excise the 23cm tumour as well as the contralateral ovary and isolated peritoneal disease, with an R0 resection achieved...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28727692/short-term-outcomes-following-cytoreductive-surgery-and-heated-intra-peritoneal-chemotherapy-at-waikato
#2
Ngov Jasen Ly, Linus Wu, Ralph Van Dalen, Simione Lolohea
AIM: Pseudomyxoma peritonei is a rare disease that affects 1-2 per million population per year. Treatment with cytoreductive surgery with heated intraperitoneal chemotherapy (CRS with IPC) has been well described. The purpose of this study was to look at the short-term outcomes following CRS with IPC for all such patients treated in Waikato. METHOD: Records for all patients presenting to surgery for CRS with IPC were retrospectively reviewed. CRS with IPC was performed in accordance with the techniques described by Sugarbaker...
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28706904/malignant-peritoneal-mesothelioma-a-review
#3
REVIEW
Joseph Kim, Shanel Bhagwandin, Daniel M Labow
Mesothelioma is a malignancy of serosal membranes. It is most commonly encountered in the visceral pleura with the second most common location in the peritoneum. The diagnosis is very rare and has been linked to toxic exposure to industrial pollutants, especially asbestos. Malignant peritoneal mesothelioma (MPM) commonly presents with diffuse, extensive spread throughout the abdomen with rare metastatic spread beyond the abdominal cavity. Due to its rarity and nonspecific symptoms, it is usually diagnosed late when the disease burden is extensive...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28701862/protective-effect-of-ginsenosides-rk3-and-rh4-on-cisplatin-induced-acute-kidney-injury-in%C3%A2-vitro-and-in%C3%A2-vivo
#4
Seung-Hoon Baek, Byong-Kyu Shin, Nam Jae Kim, Sun-Young Chang, Jeong Hill Park
BACKGROUND: Nephrotoxicity is the major side effect in cisplatin chemotherapy. Previously, we reported that the ginsenosides Rk3 and Rh4 reduced cisplatin toxicity on porcine renal proximal epithelial tubular cells (LLC-PK1). Here, we aimed to evaluate the protective effect of ginsenosides Rk3 and Rh4 on kidney function and elucidate their antioxidant effect using in vitro and in vivo models of cisplatin-induced acute renal failure. METHODS: An enriched mixture of ginsenosides Rk3 and Rh4 (KG-KH; 49...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28540833/registries-on-peritoneal-surface-malignancies-throughout-the-world-their-use-and-their-options
#5
Victor J Verwaal, Beate Rau, Faek Jamali, François Noël Gilly, Ignace de Hingh, Heikki Takala, Ingvar Syk, Jorg Pelz, Jurgen Mulsow, Kurt van der Speeten, Kusamura Shigeki, Lene H Iversen, Faheez Mohamed, Olivier Glehen, Rami Younan, Roman Yarema, Santiago Gonzalez-Moreno, Sarah O'Dwyer, Yukata Yonemura, Paul Sugarbaker
AIM: The treatment of peritoneal surface malignancies ranges from palliative care to full cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy, HIPEC. Ongoing monitoring of patient recruitment and volume is usually carried out through dedicated registries. With multiple registries available worldwide, we sought to investigate the nature, extent and value of existing worldwide CRS and HIPEC registries. METHODS: A questionnaire was sent out to all known major treatment centres...
August 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28501254/cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-colorectal-peritoneal-metastasis
#6
REVIEW
Bradley Hall, James Padussis, Jason M Foster
Historically, patients with peritoneal carcinomatosis secondary to colorectal cancer have a poor overall prognosis. Recent data support the use of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS + HIPEC) to specifically address the peritoneal disease. Retrospective studies on CRS + HIPEC have been promising, showing significant improvements in OS compared with systemic chemotherapy alone. However, CRS + HIPEC carries morbidity similar to other advance oncology procedures such as liver resection and pancreatoduonectomy...
June 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28291907/the-effects-of-hyperthermic-intraperitoneal-chemoperfusion-on-colonic-anastomosis-an-experimental-study-in-a-rat-model
#7
Afag Aghayeva, Cigdem Benlice, Ismail Ahmet Bilgin, Pinar Atukeren, Gulen Dogusoy, Figen Demir, Deniz Atasoy, Bilgi Baca
INTRODUCTION: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model...
May 12, 2017: Tumori
https://www.readbyqxmd.com/read/28187769/gastric-perforation-following-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-a-case-series-of-six
#8
Lee S Kyang, Nayef A Alzahrani, Jing Zhao, David L Morris
BACKGROUND: Incidence of gastric perforation following cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) is not widely reported. METHODS: Suitable patients were identified from our database of 1028 procedures. Relevant information was then gathered via medical records and operation reports for these patients. RESULTS: Six patients suffered early postoperative gastric perforation following the procedure (0.58%), all of whom received heated intraoperative intraperitoneal chemotherapy (HIPEC)...
February 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28058545/the-role-of-neoadjuvant-and-adjuvant-systemic-chemotherapy-with-cytoreductive-surgery-and-heated-intraperitoneal-chemotherapy-for-colorectal-peritoneal-metastases-a-systematic-review
#9
Kathryn Waite, Haney Youssef
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for colorectal peritoneal metastases (CPM), increasing overall survival in selected patients. The aim of this systematic review was to assess the effect of neoadjuvant and adjuvant systemic chemotherapy on overall survival in patients with CPM undergoing CRS and HIPEC, compared with those who receive CRS and HIPEC alone. METHODS: A systematic literature review was performed using the PubMed database, and the preferred reporting items for systematic reviews and meta-analyses guidelines formed the structure of the review...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28029523/cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-cs-hipec-in-colorectal-cancer-evidence-based-review-of-patient-selection-and-treatment-algorithms
#10
REVIEW
A H Maciver, N Lee, J J Skitzki, P M Boland, V Francescutti
Cytoreduction and heated intraperitoneal chemotherapy (CS/HIPEC) is increasingly utilized as a treatment strategy for patients with peritoneal metastases from various primary tumor sites. For this heterogenous procedure, related to patient characteristics, patient selection, and the extent of surgical completeness of cytoreduction, high level evidence (ex: multiple randomized controlled trials) is not available to support efficacy. This review of the available literature supporting application of the procedure, focusing on colorectal cancer, provides a summary of current evidence for patient selection and treatment algorithms based on patient presentation...
June 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27995450/prognostic-factors-and-significance-of-gastrointestinal-leak-after-cytoreductive-surgery-crs-with-heated-intraperitoneal-chemotherapy-hipec
#11
Konstantinos Chouliaras, Edward A Levine, Nora Fino, Perry Shen, Konstantinos I Votanopoulos
BACKGROUND: Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. METHODS: A retrospective analysis of a prospectively maintained database comprising 1270 CRS/HIPEC procedures was performed. Type of GIL, functional and resection status, morbidity, mortality, and survival were reviewed...
April 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27900630/current-delivery-of-hyperthermic-intraperitoneal-chemotherapy-with-cytoreductive-surgery-cs-hipec-and-perioperative-practices-an-international-survey-of-high-volume-surgeons
#12
Allison H Maciver, Eisar Al-Sukhni, Jesus Esquivel, Joseph J Skitzki, John M Kane, Valerie A Francescutti
BACKGROUND: Cytoreductive surgery and heated intraperitoneal chemotherapy (CS/HIPEC) is performed for selected indications at a limited number of specialized centers worldwide. Currently there is no standardized approach to the perioperative care process. We sought to capture current practices in the perioperative management of patients who undergo CS/HIPEC at high-volume centers. METHODS: Surgeon members of the American Society of Peritoneal Surface Malignancies working at high-volume CS/HIPEC centers (>10 cases/year) were invited to complete an online survey...
April 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27896510/standard-clinical-protocol-for-bidirectional-hyperthermic-intraperitoneal-chemotherapy-hipec-systemic-leucovorin-5-fluorouracil-and-heated-intraperitoneal-oxaliplatin-in-a-chloride-containing-carrier-solution
#13
Akash M Mehta, Alwin D R Huitema, Jacobus W A Burger, Alexandra R M Brandt-Kerkhof, Sander F van den Heuvel, Victor J Verwaal
BACKGROUND: Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC), but its use to date has been limited because of the morbidity caused by severe electrolyte and glycemic imbalances associated with 5% glucose as its carrier solution. This report provides an overview of the development, rationale, and application of intraperitoneal chemotherapy and the use of various drugs and carrier solutions...
April 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27830037/goblet-cell-carcinoids-of-the-appendix-tumor-biology-mutations-and-management-strategies
#14
REVIEW
Santosh Shenoy
Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers. Goblet cell carcinoids (GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. This review focuses on the current diagnostic procedures, pathogenesis, possible signaling mechanisms and treatment options for GCC. Perspectives for future research are discussed. The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27802196/prognostic-factors-for-survival-in-advanced-appendiceal-cancers
#15
Fatima Khan, Rachel I Vogel, Gustave K Diep, Todd M Tuttle, Emil Lou
BACKGROUND: Appendiceal cancer is a rare malignancy. The optimal pathologic classification and prognostic factors for survival and treatment strategies remain poorly understood. OBJECTIVE: The aim of this retrospective cohort study was to determine prognostic factors, including markers of systemic inflammation, for survival in a cohort of patients with advanced appendiceal adenocarcinomas. METHODS: The study included patients with advanced appendiceal carcinoma that were treated between January 2006 and June 2012...
2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27797810/prevention-of-vincristine-induced-peripheral-neuropathy-by-genetic-deletion-of-sarm1-in-mice
#16
Stefanie Geisler, Ryan A Doan, Amy Strickland, Xin Huang, Jeffrey Milbrandt, Aaron DiAntonio
Peripheral polyneuropathy is a common and dose-limiting side effect of many important chemotherapeutic agents. Most such neuropathies are characterized by early axonal degeneration, yet therapies that inhibit this axonal destruction process do not currently exist. Recently, we and others discovered that genetic deletion of SARM1 (sterile alpha and TIR motif containing protein 1) dramatically protects axons from degeneration after axotomy in mice. This finding fuels hope that inhibition of SARM1 or its downstream components can be used therapeutically in patients threatened by axonal loss...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27780675/oxaliplatin-versus-mitomycin-c-for-hipec-in-colorectal-cancer-peritoneal-carcinomatosis
#17
V Leung, Y R Huo, W Liauw, D L Morris
OBJECTIVE: Compare long-term outcomes in colorectal cancer (CRC) patients with peritoneal carcinomatosis (PC) treated with peritonectomy/HIPEC using oxaliplatin versus MMC. BACKGROUND: Peritonectomy and heated intraperitoneal chemotherapy (HIPEC) greatly improves patient survival in CRC PC. This procedure is not uniform across centres and the optimal choice of HIPEC chemotherapeutic is unclear. Oxaliplatin and Mitomycin C (MMC) are the most commonly used agents and comparative studies have reported varying results...
January 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27705085/the-onset-of-intra-abdominal-adhesions-during-closed-abdomen-hyperthermic-intraperitoneal-chemotherapy
#18
Marco Lotti, Michela Giulii Capponi, Luca Campanati, Elia Poiasina, Luca Ansaloni, Eugenio Poletti, Luigi Frigerio
INTRODUCTION: Hyperthermic intraperitoneal chemotherapy (HIPEC) is delivered after cytoreductive surgery (CRS) in selected patients with peritoneal carcinomatosis. The closed-abdomen technique, preferred by many centers, prevents heat loss and drug spillage, but does not warrant homogeneous distribution of the perfusion fluid (PF). The hypothesized formation of intra-abdominal adhesions during the closed-abdomen perfusion period has never been described. MATERIALS AND METHODS: From March 2014 to April 2016, 10 consecutive patients with peritoneal carcinomatosis, selected for CRS, underwent the Laparoscopy-Enhanced HIPEC technique to explore the abdominal cavity during the perfusion...
December 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27338748/adverse-events-postoperatively-had-no-impact-on-long-term-survival-of-patients-treated-with-cytoreductive-surgery-with-heated-intraperitoneal-chemotherapy-for-appendiceal-cancer-with-peritoneal-metastases
#19
Chukwuemeka Ihemelandu, Michael N Mavros, Paul Sugarbaker
BACKGROUND: Appendiceal cancer most commonly metastasizes to the peritoneum. Cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC) is the standard of care for appendiceal cancer with peritoneal metastases. Adverse events postoperatively have been associated with reduced survival. We analyzed clinical outcomes, including complications after CRS and HIPEC in patients with appendiceal cancer, in a recent cohort of patients to identify prognostic factors. METHODS: Patients undergoing CRS with HIPEC for appendix cancer with peritoneal metastases between January 2007 and December 2009 were identified...
December 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27251757/pharmacokinetics-and-the-effect-of-heat-on-intraperitoneal-pemetrexed-using-a-murine-model
#20
David Badrudin, Camille Perrault-Mercier, Antoine Bouchard-Fortier, Julien Hubert, François A Leblond, Lucas Sideris, Pierre Dubé
BACKGROUND: Pemetrexed is a systemic chemotherapeutic agent used in the treatment of malignant mesothelioma. This drug represents a potentially promising intraperitoneal (IP) agent to use for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal mesothelioma. However, this has yet to be supported by preclinical studies. Therefore, we aimed to study the effect of pemetrexed dose and perfusion temperature on the resultant pemetrexed concentration in 3 different compartments (systemic circulation, portal circulation and peritoneal tissues) using a murine model...
December 2016: Surgical Oncology
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