Wenke Shi, Jiaojiao Chen, Nan Zhao, Yun Xing, Shiqiang Liu, Mengya Chen, Wenxi Fang, Tong Zhang, Lanlan Li, Heng Zhang, Min Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Saiyang Xie, Wei Deng
AIM: Doxorubicin-induced cardiotoxicity (DIC) is an increasing problem, occurring in many cancer patients receiving anthracycline chemotherapy, ultimately leading to heart failure (HF). Unfortunately, DIC remains difficult to manage due to an ignorance regarding pathophysiological mechanisms. Our work aimed to evaluate the role of HSP47 in doxorubicin-induced HF, and to explore the molecular mechanisms. METHODS AND RESULTS: Mice were exposed to multi-intraperitoneal injection of doxorubicin (DOX, 4mg/kg/week, for 6 weeks continuously) to produce DIC...
November 22, 2023: Journal of Molecular and Cellular Cardiology