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https://www.readbyqxmd.com/read/29212656/the-relevance-and-implications-of-signet-ring-cell-adenocarcinoma-of-the-oesophagus
#1
REVIEW
Christopher William Bleaney, Mickhaiel Barrow, Stephen Hayes, Yeng Ang
AIM: To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis. METHODS: We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised...
December 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29203984/ovarian-metastases-of-colorectal-origin-treatment-patterns-and-factors-affecting-outcomes
#2
Praveen S Kammar, Reena Engineer, Prachi S Patil, Vikas Ostwal, T S Shylasree, Avanish P Saklani
The purpose of this study is to evaluate the patterns of treatment and factors affecting outcomes in ovarian metastases of colorectal origins treated at our institution and to assess the response of ovarian metastases to chemotherapy. Survival in R0 and R+ resections and patients receiving only chemotherapy is also analyzed. This is a retrospective study of 25 patients registered between January 2012 and December 2015. Patient's age, disease status, mode of presentation, disease spread, mode of treatment, response to chemotherapy, completeness of resection, histology, and outcomes were considered as variables for analysis...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202657/a-case-of-gastric-cancer-metastasis-to-the-breast-in-a-female-with-brca2-germline-mutation-and-literature-review
#3
Audrius Dulskas, Mahdi Al Bandar, Yoon Young Choi, Su-Jin Shin, Seung-Hoon Beom, Taeil Son, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
INTRODUCTION: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. PATIENTS AND METHODS: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast...
December 5, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29199692/anaplastic-lymphoma-kinase-immunohistochemistry-in-lung-adenocarcinomas-evaluation-of-performance-of-standard-manual-method-using-d5f3-antibody
#4
D Jain, K Jangra, P S Malik, S Arulselvi, K Madan, S Mathur, M C Sharma
OBJECTIVE: Immunohistochemistry (IHC) with anaplastic lymphoma kinase (ALK) antibodies is considered as an economical screening method in lung adenocarcinomas. Automated Ventana D5F3-IHC is approved by US Food and Drug Administration for targeted therapy; however, the automated IHC apparatus are not widely used in most laboratories. We evaluated the performance of ALK IHC using the manual semiquantitative method to assess the concordance with Ventana ALK IHC assay. MATERIALS AND METHODS: We tested 156 cases of primary lung adenocarcinomas for ALK protein expression by D5F3-IHC...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29192740/bilateral-parotid-gland-metastases-from-gastric-signet-ring-cell-carcinoma
#5
Federico Nichetti, Federica Morano, Alessandra Fabbri, Filippo de Braud, Maria Di Bartolomeo
INTRODUCTION: Signet-ring cell (SRC) carcinoma is a common subtype of gastric adenocarcinoma associated with poor prognosis. Metastatic involvement of the parotid gland has been reported in gastric cancer patients, but never bilaterally nor in association with the SRC histotype. Here, we report the first case and a brief review of the literature. CASE DESCRIPTION: A 47-year-old woman was referred to our center for a signet-ring gastric carcinoma with synchronous hepatic and peritoneal metastases...
November 22, 2017: Tumori
https://www.readbyqxmd.com/read/29192642/importance-of-optical-diagnosis-in-early-gastric-cancer-a-case-report-of-early-gastric-signet-ring-cell-carcinoma
#6
P S Akabah, S Mocan, C Molnar, D Dobru
Gastric signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma. It is an epithelial malignancy characterized by the histologic appearance of more than 50% of cells as signet ring cells filled with mucin. The incidence of SRCC is rising,[1],[2] therefore, the diagnosis of these cancers in the early stage is important as it is the only stage that curative measures can be done. A 49-year-old female was hospitalized due to epigastric pain, postprandial bloating for 3 months. Upper gastrointestinal endoscopy with narrow band imaging (NBI) showed 1...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29187442/updated-histologic-classification-of-adenomas-and-carcinomas-in-the-colon-of-carcinogen-treated-sprague-dawley-rats
#7
Carlos A Rubio
BACKGROUND: Recent studies have disclosed novel histological phenotypes of colon tumours in carcinogen-treated rats. The aim of this study was to update the current histological classification of colonic neoplasias in Sprague-Dawley (SD) rats. MATERIALS AND METHODS: Archival sections from 398 SD rats having 408 neoplasias in previous experiments were re-evaluated. RESULTS: Of the 408 colonic neoplasias, 11% (44/408) were adenomas without invasive growth and 89% (364/408) invasive carcinomas...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29178101/-clinicopathologic-characteristics-and-prognosis-analysis-of-90-young-patients-with-gastric-cancer
#8
Rongjian Zhou, Junjie Zhao, Ping Shu, Hongshan Wang, Jing Qin, Yihong Sun
OBJECTIVE: To investigate the features of clinicopathology and prognosis in young gastric cancer patients. METHODS: Clinicopathological data of 90 young gastric cancer patients (≤40 years old) who received radical gastrectomy in the Department of General Surgery of Zhongshan Hospital, Fudan University from January 2013 to December 2014 were retrospectively analyzed. Survival data were obtained by follow-up and the last follow-up time was October 2016. Log-rank test and Cox regression model were used to analyze the risk factors of prognosis and these factors included gender, age, tumor size, degree of differentiation, histological type, Lauren pattern, T stage, N stage, vessel carcinoma embolus, clinical symptom, anemic condition, CA19-9 level, et al...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29178100/-lymph-node-metastasis-regularity-and-risk-factors-in-768-cardiac-carcinoma-patients
#9
Jie Yue, Xiaofeng Duan, Lei Gong, Jianguo Zhang, Zhentao Yu
OBJECTIVE: To investigate the regularity of lymph node metastasis in cardiac carcinoma and its risk factors. METHOD: Complete clinicopathological data of 768 cardiac carcinoma patients undergoing radical resection and lymph node dissection were collected. A retrospective cohort study was performed to analyze the distribution of lymph node metastasis (lymph node metastasis rate=number of patients with lymph node metastasis/number of patients with lymph node dissection; lymph node metastasis frequency=number of metastatic lymph node/number of total resected lymph node) and the influence of clinicopathological factors on lymph node metastasis...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29172819/arias-stella-reaction-with-signet-ring-like-cell-histomorphology
#10
Andrea Hernandez, Jeanine Chiaffarano, Khushbakhat Mittal, Alan Marcus
Cells with their nucleus pushed to the periphery in a crescent-like fashion by intracytoplasmic vacuole(s) are referred to as signet ring cells when the vacuole(s) contain mucin and signet ring-like cells when they are empty or contain a material other than mucin. Signet ring cells are commonly associated with adenocarcinomas. These cells are uncommon in the endometrium and have been found to be associated with both malignant and benign processes. We report the first case of signet ring-like cells within endometrial glands with Arias-Stella reaction...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29166862/gastric-stump-carcinoma-as-a-long-term-complication-of-pancreaticoduodenectomy-report-of-two-cases-and-review-of-the-english-literature
#11
Morgane Bouquot, Safi Dokmak, Louise Barbier, Jérôme Cros, Philippe Levy, Alain Sauvanet
BACKGROUND: Gastric stump carcinoma is an exceptional and poorly known long-term complication after pancreaticoduodenectomy. CASES PRESENTATION: Two patients developed gastric stump carcinoma 19 and 10 years after pancreaticoduodenectomy for malignant ampulloma and total pancreaticoduodenectomy for pancreatic adenocarcinoma, respectively. Both patients had pT4 signet-ring cell carcinoma involving the gastrojejunostomy site that was revealed by bleeding or obstruction...
November 22, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29164283/gastric-cancer-metastatic-to-neck-lipoma-a-case-report-with-imaging-consideration
#12
Shuko Nomura, Noriko Kurihara, Tomohiko Ishikawa, Masaru Tateda, Junko Sakurada
A 71-year-old man visited our hospital for examination of a soft neck mass. Computed tomography and magnetic resonance imaging scans showed a well-circumscribed large lipomatous tumor with multiple nodules inside. Atypical lipomatous tumor or lipoma involving the lymph nodes was considered. Pathological examination of the surgical specimen suggested typical lipoma including multiple metastatic foci from gastric cancer. Subsequent endoscopy revealed a gastric tumor, which was histologically proven to be signet-ring cell carcinoma...
November 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29159742/validation-of-the-recent-psogi-pathological-classification-of-pseudomyxoma-peritonei-in-a-single-center-series-of-265-patients-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#13
Dario Baratti, Shigeki Kusamura, Massimo Milione, Federica Bruno, Marcello Guaglio, Marcello Deraco
BACKGROUND: Controversies still persist regarding the terminology and pathologic classification of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei (PMP). We assessed reproducibility and prognostic significance of the classification recently proposed by the Peritoneal Surface Oncology Group International (PSOGI). METHODS: A prospective database of 265 PMP patients uniformly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) from 1995 to 2017 was reviewed...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29151922/clinicopathological-characteristics-and-prognostic-value-of-signet-ring-cells-in-gastric-carcinoma-a-meta-analysis
#14
Run-Cong Nie, Shu-Qiang Yuan, Yuan-Fang Li, Yong-Ming Chen, Xiao-Jiang Chen, Bao-Yan Zhu, Li-Pu Xu, Zhi-Wei Zhou, Shi Chen, Ying-Bo Chen
Background and Objectives: Previous studies of the prognostic value of the signet ring cell (SRC) type have yielded inconsistent results. Therefore, the aim of the present meta-analysis is to explore the clinicopathological characteristics and prognostic value of SRCs. Methods: Relevant articles that compared SRC and non-SRC type in PubMed and Web of Science were comprehensively searched. Then, a meta-analysis was performed. Results: A total of 19 studies including 35947 cases were analyzed. Compared with non-SRC patients, SRC patients tended to be younger (WMD: -3...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29143897/anaplastic-lymphoma-kinase-testing-ihc-vs-fish-vs-ngs
#15
REVIEW
Xiaomin Niu, Jody C Chuang, Gerald J Berry, Heather A Wakelee
Personalized targeted therapy has emerged as a promising strategy in lung cancer treatment, with current attention focused on elucidation and detection of oncogenic drivers responsible for tumor initiation and maintenance and development of drug resistance. In lung cancer, several oncogenic drivers have been reported, triggering the application of tyrosine kinase inhibitors (TKIs) to target these dysfunctional genes. The anaplastic lymphoma kinase (ALK) rearrangement is responsible for about 4-7% of all non-small cell lung cancers (NSCLCs) and perhaps as high as a third in specific patient populations such as younger, male, non-smokers with advanced stage, epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) wild type, and signet ring cell adenocarcinoma with abundant intracytoplasmic mucin...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29138597/characteristics-and-prognostic-factors-of-colorectal-mucinous-adenocarcinoma-with-signet-ring-cells
#16
Xiangquan Kong, Xueqing Zhang, Yunxia Huang, Lirui Tang, Qingqin Peng, Jinluan Li
Background: Colorectal signet ring cell (SRC) carcinoma occurs rarely with a poor prognosis. The present study assessed the prognostic factors and predictive value of SRC ratio in colorectal mucinous adenocarcinoma (MAC) with SRCs (MAC-SRC). Patients and methods: A total of 95 consecutive colorectal MAC-SRC patients, confirmed pathologically from February 1987 to December 2015, were analyzed retrospectively in our institute. Clinical characteristics, pathological grade, TNM staging, and SRC ratio were assessed to identify the prognostic factors related to progression-free survival (PFS) and overall survival (OS)...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#17
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29131691/a-new-mutation-of-the-cdh1-gene-in-a-patient-with-an-aggressive-signet-ring-cell-carcinoma-of-the-stomach
#18
Laura Caggiari, Gianmaria Miolo, Vincenzo Canzonieri, Mariangela De Zorzi, Lara Alessandrini, Giuseppe Corona, Renato Cannizzaro, Davide Adriano Santeufemia, Antonio Cossu, Angela Buonadonna, Valli De Re
Germline mutations in CDH1, the gene coding for the E-cadherin adhesion protein, are known to cause hereditary diffuse gastric cancer. We identified a new truncating germline mutation (p.Asp538Thrfs*19) in exon 11 of the CDH1 gene in a 41-year-old male with a diffuse gastric cancer. Although he had no parental history of gastric cancer, the co-segregation study in the family detected the same mutation in his healthy 31-year-old brother. The mutation affects one of the extracellular repeat (CAD repeats) domains which is essential for the homophilic binding specificity that directs "E-cadherin" to bind with itself each others...
November 13, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29129333/pitfalls-in-the-interpretation-of-specimens-from-patients-with-testicular-tumours-with-an-emphasis-on-variant-morphologies
#19
REVIEW
Thomas M Ulbright
Accurate diagnosis of primary and metastatic tumours is essential in testicular cancer. While many cases are straightforward, some pose difficulties, especially when variant morphologies occur. Seminoma with 'atypical' features, including increased nuclear pleomorphism and crowding and greater cytoplasmic density with loss of membrane definition, mimics embryonal carcinoma, although ancillary features (fibrous septa, lymphocytes) and immunohistochemistry are of great help. Other deceptive seminoma features include prominent to exclusive intertubular growth, microcystic/tubular patterns, and signet-ring tumour cells...
November 9, 2017: Pathology
https://www.readbyqxmd.com/read/29119740/breast-metastasis-of-gastric-signet-ring-cell-carcinoma
#20
Li-Yuan Wei, Mei Kong, Zhen Zhang, Xiao-Chen Zhang
Metastatic breast involvement from extra-mammary neoplasms is unusual with a low incidence of 0.5% to 1.2% in clinical practice, 2.7% in cytological series, and 1.7% to 6.6% in autopsy series of all breast malignancies. Nearly 500 cases have been reported in small series and case reports. Gastric carcinoma rarely metastasizes to the breast. There are only 38 cases reported in PubMed. In this study, we present a case report of a 49-year-old woman who was diagnosed with right breast metastasis from a gastric carcinoma and undertake a literature review to pay attention to the diagnosis, treatment, and the prognosis of the disease...
2017: Journal of Zhejiang University. Science. B
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