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signet cell

Vivian E Strong, Sepideh Gholami, Manish A Shah, Laura H Tang, Yelena Y Janjigian, Mark Schattner, Luke V Selby, Sam S Yoon, Erin Salo-Mullen, Zsofia K Stadler, David Kelsen, Murray F Brennan, Daniel G Coit
OBJECTIVE: The aim of this study was to describe postoperative outcomes of total gastrectomy at our institution for patients with hereditary diffuse gastric cancer (HDGC). BACKGROUND: HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. METHODS: A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015...
October 17, 2016: Annals of Surgery
G W Wang, D H Shen, W Y Zhang, K X Xu, T Xu, H Hu
OBJECTIVE: To assess the changing trends in Gleason score (GS) of Chinese prostate carcinoma (PCa) from January 1995 to December 2014. METHODS: In the study, 875 patients admitted to hospital from January 1995 to December 2004 (1995-2004) and from January 2005 to December 2014 (2005-2014) were divided into two groups. The mean levels and proportions of GS, primary and secondary grades were studied. The patients were divided into four groups according to age: <60, 60-69, 70-79 and ≥80 years...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Mohamed Fetohi, Sanaa Errarhay, Aziz Bazine, Tarikq Namad
BACKGROUND: Krukenberg tumor is a well-known ovarian metastasis, usually of signet ring cell carcinoma in female patients. In the literature, there are a few documented cases of ocular metastasis in patients with Krukenberg tumor. CASE PRESENTATION: We report the case of a 35-year-old single Moroccan woman. She presented chronic pelvic pain, hematemesis and blurring of vision in the left eye. Clinical examination showed a pelvic mass and an exophthalmos with a divergent strabismus in the left eye...
May 2016: Case Reports in Oncology
Jing Zhao, Jing Zheng, Mei Kong, Jianya Zhou, Wei Ding, Jianying Zhou
Defining distinctive histologic characteristics of ROS1-rearranged non-small-cell lung carcinomas (NSCLCs) may help identify cases that merit molecular testing. However, the majority of previous reports have focused on surgical specimens but only limited studies assessed histomorphology of advanced NSCLCs. In order to identify the clinical and histological characteristics of ROS1-rearranged advanced NSCLCs, we examined five hundred sixteen Chinese patients with advanced NSCLCs using ROS1 fluorescence in situ hybridization and real-time polymerase chain reaction and then analyzed for clinical and pathological features...
September 30, 2016: Oncotarget
Koji Morita, Takahiko Sakamoto, Shuji Ota, Hideo Masugi, Ikumi Chikuta, Yamato Mashimo, Naoki Edo, Takuo Tokairin, Nobuhiko Seki, Toshio Ishikawa
It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, or may involve the whole thyroid gland diffusely. However, diffuse metastasis of gastric cancer to the thyroid is extremely rare. Here, we report a case of a 74-year-old woman with diffuse infiltration of gastric adenocarcinoma (signet-ring-cell carcinoma/poorly differentiated adenocarcinoma) cells in the thyroid. The pathological diagnosis was made based on upper gastrointestinal endoscopy with biopsy and fine-needle aspiration cytology of the thyroid...
October 1, 2016: Journal of Medical Ultrasonics
Alexandra Grosse
Amebiasis is uncommon in developed countries. Several case reports in the literature emphasize that both the presenting symptoms and the radiological findings of colonic amebiasis closely resemble more common conditions, such as idiopathic inflammatory bowel disease and gastro-intestinal malignancy. We describe a unique case of colonic amebiasis (amebomas) coexisting with signet-ring cell carcinoma of the ileocecal valve, the cecum and the appendix. Endoscopically, the ulcerated tumor was indistinguishable from the ulcerations and pseudotumors (amebomas) detected in the ascending colon...
September 28, 2016: World Journal of Gastroenterology: WJG
Dimitrios Pantelis, Robert Hüneburg, Ronja Adam, Stefanie Holzapfel, Heidrun Gevensleben, Jacob Nattermann, Christian P Strassburg, Stefan Aretz, Jörg C Kalff
PURPOSE: Germline mutations in several genes confer a relevant lifetime risk of gastric cancer. In this context, an increasing involvement of a surgeon can be seen, mainly with the question of performing a prophylactic operation. METHODS: Patients with hereditary tumor syndromes predisposing for gastric cancer who received care leading to prophylactic total gastrectomy in our Center for Hereditary Tumor Syndromes were analyzed. For each patient, the multidisciplinary decision-making process, the perioperative course, and the histopathologic findings were assessed...
September 28, 2016: International Journal of Colorectal Disease
Srijan Mazumdar, Sridhar Sundaram, Prachi Patil, Shaesta Mehta, Mukta Ramadwar
Adenocarcinomas are the most common cancers affecting stomach. However gastrointestinal stromal tumors (GIST), lymphomas and neuroendocrine tumors (NETs) can also affect the stomach. But stomach is relatively rare site of involvement by metastasis. In this case report a rare metastasis of germ cell tumor (GCT) into stomach is described which clinically and endoscopically masquerade as primary gastric cancers. But detailed clinical examination and vigilant histopathological reporting proves the origin of tumor distant from stomach and thereby change the whole approach of management...
August 2016: Annals of Translational Medicine
Deniz Tuncel, Juan Carlos Roa, Juan Carlos Araya, Enrique Bellolio, Miguel Villaseca, Oscar Tapia, Kee-Taek Jang, Brian Quigley, Burcu Saka, Olca Basturk, Juan Sarmiento, Hector F Losada, Samip Patel, Michelle D Reid, Bahar Memis, Volkan Adsay
Signet-ring cell carcinoma is an extremely rare type of gallbladder carcinoma. In the gastrointestinal system, carcinomas with single-cell or cord-like infiltration, previously called "diffuse-infiltrative" type or "signet-ring cell", are now designated as "poorly cohesive cell" (PCC) type (regardless of with/without signet-ring cells) in the WHO-2010 classification. 628 primary invasive gallbladder carcinomas were reviewed for the PCC pattern. 24 cases in which classical poorly cohesive cell pattern constituted >50% of the tumor were included in the study...
September 22, 2016: Human Pathology
Yon Hee Kim, Ji Hye Park, Cheol Keun Park, Jie-Hyun Kim, Sang Kil Lee, Yong Chan Lee, Sung Hoon Noh, Hyunki Kim
BACKGROUND: The prediction of biologic behavior of poorly cohesive early gastric carcinoma (EGC) is an important issue in the selection of the treatment modality. To elucidate the risk factors for lymph node metastasis (LNM) of poorly cohesive EGC, we focused on the histologic purity of the poorly cohesive component and evaluated the impact of this factor on LNM. METHODS: We divided poorly cohesive EGC into (1) pure signet ring cell (SRC) carcinoma, which was defined as composed only of signet ring cells or poorly cohesive cells and (2) mixed SRC carcinoma, defined as poorly cohesive carcinoma with minor tubular components...
September 23, 2016: Gastric Cancer
Y J Zhang, J Wang, X L Zhang, Q Liu, S W Jing, Y Wang, F Cao, W P Jiao
Objective: To explore the patterns and influencing factors of lymph node metastasis of adenocarcinoma of the esophagogastric junction (AEG). Methods: Clinicopathological data of 393 AEG patients who underwent radical resection and lymphadenectomy in the thoracic or abdominal cavity were collected. We analyzed the metastatic patterns of 5 119 excised lymph nodes with an average of 13 nodes per patient according to Siewert classification, and the associations between lymphatic metastasis and clinicopathological factors, such as tumor invasion, differentiation, maximum diameter, or pathological type were analyzed...
September 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Yakup Bozkaya, Gökmen Umut Erdem, Nuriye Yıldırın Ozdemir, Nebi Serkan Demirci, Cemil Hocazade, Ozan Yazıcı, Nurullah Zengin
AIM: To determine whether there are any clinicopathological or prognostic differences between mucinous gastric carcinoma (MGC) and signet ring cell carcinoma (SRCC). METHODS: Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with MGC and SRCC. RESULTS: In total, 193 patients (51 with MGC and 142 with SRCC) were included in this study. Patients with SRCC in particular had notably higher lymphovascular invasion, perineural invasion, rate of Borrmann types III and IV, and stage III-IV cancer (according to its TNM stage) compared with patients with MGC...
October 18, 2016: Current Medical Research and Opinion
Amit Verma, Vinay Tomar
Signet ring cell carcinoma of urachus is a very rare tumour. It generally presents as a high grade, high stage tumour and in most of the cases it has regional or distant metastasis at the time of presentation. It is known to have a uniformly poor prognosis. We present here a very interesting and rare case report of signet ring cell carcinoma of urachus in a 61-year-old male who presented with irritative lower urinary tract symptoms and pain abdomen. High index of suspicion led to the early diagnosis and timely surgical intervention...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Diana Murro Lin, Ji-Weon Park, Paolo Gattuso
Primary bladder signet-ring cell carcinoma (SRCC) is extremely rare and associated with an aggressive course. To our knowledge, we describe the first metastatic bladder SRCC identified in cerebrospinal fluid (CSF). A 68-year-old male with 1 year history of primary bladder SRCC with spinal metastasis presented with multiple falls and loss of consciousness. Brain imaging showed high signal in the frontoparietal sulci and superior cerebellum. CSF analysis was significant for increased leukocytes with monocyte predominance while protein and glucose values were within normal range...
September 15, 2016: Diagnostic Cytopathology
Takao Hara, Tsuyoshi Etoh, Yoshitake Ueda, Yuki Shitomi, Hidefumi Shiroshita, Norio Shiraishi, Tsutomu Daa, Masafumi Inomata
BACKGROUND: Endoscopic resection is accepted as the standard treatment for early mucosal gastric cancer, and its indications have recently been expanded while its long-term outcomes are still unclear. Herein, we present a didactic case of undifferentiated-type mucosal gastric cancer fulfilling the expanded indication and curative criteria for endoscopic submucosal dissection (ESD), having synchronous multiple lymph node metastases. CASE PRESENTATION: A 40-year-old woman was found to have a Helicobacter pylori infection at a standard health check with no abdominal symptoms...
December 2016: Surgical Case Reports
X Cai, W-X Qi, L Wang, Z Zhang
OBJECTIVE: Primary colorectal cancer (CRC) with signet-ring cell (SRC) component is a distinct tumor of colon and rectum, and its prognosis is very poor. Reliable markers to predict the poor clinical outcome of this subgroup cancer remains undetermined. Therefore, we perform this study to investigate the prognosis value of seven proteins in CRC with SRC component . PATIENTS AND METHODS: This study involved 117 patients diagnosed with CRC with SRC component between January 2008 and August 2015 at Fudan University Shanghai Cancer Center...
August 2016: European Review for Medical and Pharmacological Sciences
Rakul Nambiar, Sunil Prasobh Prabhakaran, Padmakumar Rajasekharan Pillai, D Dalus
We report a case of gastric signet cell carcinoma, presenting as cardiac tamponade, in a young male patient. The diagnosis of gastric signet cell carcinoma was confirmed by immunohistochemistry of the lymph node specimen in our patient.
October 2015: Journal of the Association of Physicians of India
Chaoqun Han, Rong Lin, Huiying Shi, Jun Liu, Wei Qian, Zhen Ding, Xiaohua Hou
Endoscopic ultrasonography (EUS) is used for preoperative assessment of gastric cancer. However, recent studies suggested that EUS staging accuracy is lower than previously thought. We aimed to assess EUS efficacy and image characteristics in preoperative gastric cancer T staging.A retrospective review of clinical and imaging features of 232 gastric carcinoma patients who underwent preoperative EUS assessment of T stage was performed. Only cases with tumor-free resection margin status and no metastases were enrolled...
September 2016: Medicine (Baltimore)
I A Kazantseva, S V Lishchuk, Yu P Gribunov, I N Shestakova, K A Pavlov
The paper presents the data available in the literature on IgG4-related disease (IgG4-RD) concurrent with malignancies at different sites, as well as possible common pathogenetic mechanisms of their development and morphological diagnostic criteria for IgG4-RD. The authors give their own observation of gastric signet ring cell carcinoma concurrent with morphologically verified IgG4-RD.
July 2016: Arkhiv Patologii
Ji Fu Lai, Wen Na Xu, Sung Hoon Noh, Wei Qin Lu
BACKGROUND The World Health Organization (WHO) histological classification for gastric cancer is widely accepted and used. However, its impact on predicting lymph node metastasis and recurrence in early gastric cancer (EGC) is not well studied. MATERIAL AND METHODS From 1987 to 2005, 2873 EGC patients with known WHO histological type who had undergone curative resection were enrolled in this study. In all, 637 well-differentiated adenocarcinomas (WD), 802 moderately-differentiated adenocarcinomas (MD), 689 poorly-differentiated adenocarcinomas (PD), and 745 signet-ring cell adenocarcinomas (SRC) were identified...
September 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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