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https://www.readbyqxmd.com/read/29159742/validation-of-the-recent-psogi-pathological-classification-of-pseudomyxoma-peritonei-in-a-single-center-series-of-265-patients-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#1
Dario Baratti, Shigeki Kusamura, Massimo Milione, Federica Bruno, Marcello Guaglio, Marcello Deraco
BACKGROUND: Controversies still persist regarding the terminology and pathologic classification of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei (PMP). We assessed reproducibility and prognostic significance of the classification recently proposed by the Peritoneal Surface Oncology Group International (PSOGI). METHODS: A prospective database of 265 PMP patients uniformly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) from 1995 to 2017 was reviewed...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29149865/cytoreductive-surgery-and-hyperthermic-intra-operative-peritoneal-chemotherapy-with-cisplatin-for-gastric-peritoneal-carcinomatosis-monocentric-phase-2-nonrandomized-prospective-clinical-trial
#2
Baki Topal, Karel Demey, Halit Topal, Joris Jaekers, Eric Van Cutsem, Vincent Vandecaveye, Xavier Sagaert, Hans Prenen
BACKGROUND: Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking. METHODS: Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%)...
November 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29143892/update-in-the-therapy-of-advanced-neuroendocrine-tumors
#3
REVIEW
Inbal Uri, Shani Avniel-Polak, David J Gross, Simona Grozinsky-Glasberg
Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from endocrine cells of the gastrointestinal tract and the pancreas, thus being referred to as gastroenteropancreatic NETs (GEP-NETs). The only treatment that offers a cure is surgery; however, most patients are diagnosed with metastatic disease, and curative surgery is usually not an option. These patients can be offered long-term systemic treatment, for both symptomatic relief and tumor growth suppression...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143144/carcinosarcoma-of-the-ovary-compared-to-ovarian-high-grade-serous-carcinoma-impact-of-optimal-cytoreduction-and-standard-adjuvant-treatment
#4
Ibrahim Yalcin, Mehmet Mutlu Meydanli, Ahmet Taner Turan, Salih Taskin, Mustafa Erkan Sari, Tayfun Gungor, Ozgur Akbayir, Ali Ayhan
OBJECTIVE: The purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner. METHODS: A multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey...
November 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29137079/treatment-of-hypermyoglobinemia-after-crs-hipec-for-patients-with-peritoneal-carcinomatosis-a-retrospective-comparative-study
#5
Gang Liu, Zhong-He Ji, Yang Yu, Xin-Bao Li, Yan-Bin Zhang, Kai-Wen Peng, Yan Li
This retrospective comparative study aims to explore the time courses of serum myoglobin (Mb) changes, and summarize our experience in treating patients with hypermyoglobinemia after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).This study covered 60 patients with peritoneal carcinomatosis treated with CRS + HIPEC as the study group, and another 25 cancer patients treated with conventional extensive surgery without HIPEC as the control group from February to October 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135123/hepatobiliary-and-pancreatic-procedures-during-cytoreductive-surgery-and-hipec
#6
Ioannis Kyriazanos, Nikolaos Kopanakis, Vasileios Kalles, Alexios Tzivanakis, Georgios Nikolaou, Elias Efstathiou, John Spiliotis
PURPOSE: The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been used as locoregional treatment in selected patients with peritoneal malignancy. The purpose of this study was to report on the outcomes of patients undergoing hepatobiliary and pancreatic procedures during CRS and HIPEC. METHODS: A prospectively maintained database was used to identify patients that underwent hepatobilliary and/or pancreatic procedures during CRS and HIPEC...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135095/does-upfront-therapy-with-cytoreductive-surgery-and-hipec-confer-a-survival-benefit-in-patients-with-synchronous-gastric-peritoneal-carcinomatosis-when-compared-with-patients-with-metachronous-gastric-peritoneal-carcinomatosis
#7
Nikolaos Kopanakis, Elias Efstathiou, Dimitrios Sarris, John Spiliotis
Gastric cancer (GC) remains the second leading cause of cancer death worldwide, accounting for 8% of the total cases and 10% of total deaths in 2008. Surgery remains the curative treatment option for GC and the main reason for treatment failure is peritoneal recurrence which, according to the literature, occurs in 40-60% of the cases, despite extensive surgery including D2 lymph node dissection. The hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the treatment of primary and digestive peritoneal carcinomatosis (PC), in association with cytoreductive surgery (CRS)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134372/systematic-review-of-cytoreductive-surgery-and-bevacizumab-containing-chemotherapy-in-advanced-ovarian-cancer-focus-on-safety
#8
REVIEW
Marco Petrillo, Camilla Nero, Vittoria Carbone, Matteo Bruno, Giovanni Scambia, Anna Fagotti
BACKGROUND: Initial experiences reported increased surgical morbidities in patients receiving cytoreductive surgery for colorectal cancer after bevacizumab-containing chemotherapy; however, more recent literature suggests a favorable toxicity profile in patients with advanced ovarian cancer (AOC). With the aim of providing a more objective point of view on this controversial issue, we present here a systematic literature review. METHODS: Systematic revision of the available literature was conducted using the PubMed, MEDLINE, and EMBASE electronic databases...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29132061/synchronous-peritoneal-metastases-of-small-bowel-adenocarcinoma-insights-into-an-underexposed-clinical-phenomenon
#9
Laura M Legué, Geert A Simkens, Geert-Jan M Creemers, Valery E P P Lemmens, Ignace H J T de Hingh
BACKGROUND: The aim of this population-based study was to provide insight into the incidence, risk factors and treatment-related survival of patients with peritoneal metastases (PM) of small bowel adenocarcinoma (SBA). METHODS: Data from the Netherlands Cancer Registry were used. All patients diagnosed with SBA between 2005 and 2014 were included. The influence of patient and tumour characteristics on the odds of developing PM was analysed. Subsequently, for all further analyses, patients without synchronous PM of SBA were excluded...
November 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29129391/centralization-of-ovarian-cancer-in-the-netherlands-hospital-of-diagnosis-no-longer-determines-patients-probability-of-undergoing-surgery
#10
Maite Timmermans, Melinda S Schuurman, Vincent K Y Ho, Leon F Massuger, Hans W Nijman, Toon van Gorp, Gabe S Sonke, Roy F P M Kruitwagen, Maaike A van der Aa
OBJECTIVE: Surgical care for advanced stage epithelial ovarian cancer (EOC) patients has been centralized in the Netherlands since 2012. We evaluated whether the likelihood for patients to undergo surgery depends on the hospital of initial diagnosis before and after centralization of surgical care. METHODS: Patients with EOC FIGO stage IIB-IV, diagnosed in the Netherlands between 2000 and 2015, were identified from the Netherlands Cancer Registry. Multilevel multivariate logistic regression was used to study the association between hospital of diagnosis and patients' likelihood of undergoing surgery in subsequent time periods...
November 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128106/who-are-the-long-term-survivors-of-high-grade-serous-ovarian-cancer
#11
REVIEW
Claire Hoppenot, Mark A Eckert, Samantha M Tienda, Ernst Lengyel
Although the median survival for epithelial ovarian cancer (EOC) is <5years, approximately 15% of patients will survive for >10years. A better understanding of these exceptional responders could reveal opportunities to improve the dismal prognosis of most EOC patients. In this review, we examine the clinical and genomic features that have been associated with long-term survival, which is generally defined as survival of >7-10years after initial diagnosis. Clinical features influencing long-term survival have been best reported in large retrospective population-based studies...
November 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128105/factors-associated-with-delivery-of-neoadjuvant-chemotherapy-in-women-with-advanced-stage-ovarian-cancer
#12
Emily Hinchcliff, Alexander Melamed, Amy Bregar, Elisabeth Diver, Joel Clemmer, Marcela Del Carmen, John O Schorge, J Alejandro Rauh-Hain
PURPOSE: To identify clinical and non-clinical factors associated with utilization of primary cytoreductive surgery (PCS) or neoadjuvant chemotherapy (NACT) in women with advanced stage epithelial ovarian cancer (EOC). METHODS: Using the National Cancer Database, we identified women with stage IIIC and IV EOC diagnosed from 2012 to 2014. The primary outcome was receipt of NACT, defined in the primary analysis as utilization of chemotherapy as the first cancer-directed therapy, irrespective of whether interval surgery was performed...
November 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29122377/the-role-of-surgery-in-metastatic-bladder-cancer-a-systematic-review
#13
REVIEW
Mohammad Abufaraj, Guido Dalbagni, Siamak Daneshmand, Simon Horenblas, Ashish M Kamat, Ryu Kanzaki, Alexandre R Zlotta, Shahrokh F Shariat
CONTEXT: The role of surgery in metastatic bladder cancer (BCa) is unclear. OBJECTIVE: In this collaborative review article, we reviewed the contemporary literature on the surgical management of metastatic BCa and factors associated with outcomes to support the development of clinical guidelines as well as informed clinical decision-making. EVIDENCE ACQUISITION: A systematic search of English language literature using PubMed-Medline and Scopus from 1999 to 2016 was performed...
November 6, 2017: European Urology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#14
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29120491/clinical-studies-in-crs-and-hipec-trials-tribulations-and-future-directions-a-systematic-review
#15
William F Morano, Marian Khalili, Dennis S Chi, Wilbur B Bowne, Jesus Esquivel
BACKGROUND: The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. OBJECTIVE: To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. METHODS: Systematic review by PubMed search was performed using terms "Clinical trial," "intraperitoneal chemotherapy," and "HIPEC...
November 9, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29117194/a-pre-operative-predictive-score-to-evaluate-the-feasibility-of-complete-cytoreductive-surgery-in-patients-with-epithelial-ovarian-cancer
#16
Marion Chesnais, Fabrice Lecuru, Myriam Mimouni, Charlotte Ngo, Arnaud Fauconnier, Cyrille Huchon
OBJECTIVE: Postoperative residual tumor is the major prognostic factor in ovarian cancer. The feasibility of complete cytoreductive surgery is assessed by laparoscopy. Our goal was to develop a predictive score prior to laparoscopy to evaluate the feasibility of complete cytoreductive surgery in patients with epithelial ovarian cancer. METHODS: We developed a score to predict incomplete cytoreductive surgery by performing multiple logistic regressions after bootstrap procedures on data from a retrospective cohort of 247 patients with advanced ovarian cancer...
2017: PloS One
https://www.readbyqxmd.com/read/29113651/the-role-of-f18-fdg-pet-ct-in-predicting-secondary-optimal-de-bulking-in-patients-with-recurrent-ovarian-cancer
#17
Amnon Amit, Adina Hodes, Ofer Lavie, Zohar Keidar, Emad Matanes, Lior Lowenstein
BACKGROUND AND OBJECTIVES: The decision to perform secondary cytoreductive surgery for recurrent ovarian cancer is generally determined by clinical criteria. The aim of this study was to assess the predictive capability of FDG-PET/CT in identifying patients for whom secondary optimal debulking can be obtained. METHODS: We reviewed the records of all women with suspected recurrent ovarian cancer (CA-125 levels >35 U/ml and/or clinical symptoms), at two medical centers, between January 2004 and December 2013...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29111390/treatment-of-peritoneal-carcinomatosis-with-photodynamic-therapy-systematic-review-of-current-evidence
#18
REVIEW
Muhammad Qutayba Almerie, Gemma Gossedge, Kathleen E Wright, David G Jayne
BACKGROUND: Peritoneal carcinomatosis results when tumour cells implant and grow within the peritoneal cavity. Treatment and prognosis vary based on the primary cancer. Although therapy with intention-to-cure is offered to selective patients using cytoreductive surgery with chemotherapy, the prognosis remains poor for most of the patients. Photodynamic therapy (PDT) is a cancer-therapeutic modality where a photosensitiser is administered to patients and exerts a cytotoxic effect on cancer cells when excited by light of a specific wavelength...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29110275/impact-of-cellularity-on-oncologic-outcomes-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemoperfusion-for-pseudomyxoma-peritonei
#19
Haroon A Choudry, Reetesh K Pai, Yongli Shuai, Lekshmi Ramalingam, Heather L Jones, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Amer H Zureikat, Herbert J Zeh, David L Bartlett
BACKGROUND: The Peritoneal Surface Oncology Group International (PSOGI) recommends pathologic reporting of tumor cellularity in patients with pseudomyxoma peritonei (PMP) undergoing cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC). We investigated the prognostic significance of PMP cellularity, or lack thereof (acellular mucin), following CRS-HIPEC. METHODS: We reviewed clinical data for 310 CRS-HIPEC procedures in low-grade (American Joint Committee on Cancer grade G1) PMP with acellular mucin (n = 19), scant cellularity (n = 30), or moderate cellularity (n = 242)...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29100461/nanoparticle-as-a-novel-tool-in-hyperthermic-intraperitoneal-and-pressurized-intraperitoneal-aerosol-chemotheprapy-to-treat-patients-with-peritoneal-carcinomatosis
#20
REVIEW
Maciej Nowacki, Margarita Peterson, Tomasz Kloskowski, Eleanor McCabe, Delia Cortes Guiral, Karol Polom, Katarzyna Pietkun, Barbara Zegarska, Marta Pokrywczynska, Tomasz Drewa, Franco Roviello, Edward A Medina, Samy L Habib, Wojciech Zegarski
The treatment of peritoneal surface malignances has changed considerably over the last thirty years. Unfortunately, the palliative is the only current treatment for peritoneal carcinomatosis (PC). Two primary intraperitoneal chemotherapeutic methods are used. The first is combination of cytoreductive surgery (CRS) and Hyperthermic IntraPEritoneal Chemotherapy (HIPEC), which has become the gold standard for many cases of PC. The second is Pressurized IntraPeritoneal Aerosol Chemotheprapy (PIPAC), which is promising direction to minimally invasive as safedrug delivery...
September 29, 2017: Oncotarget
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