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https://www.readbyqxmd.com/read/28430350/1st-evidence-based-italian-consensus-conference-on-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-carcinosis-from-ovarian-cancer
#1
Davide Cavaliere, Roberto Cirocchi, Federico Coccolini, Anna Fagotti, Massimiliano Fambrini, Orietta Federici, Domenica Lorusso, Marco Vaira, Marco Ceresoli, Paolo Delrio, Alfredo Garofalo, Sandro Pignata, Paolo Scollo, Vito Trojano, Andrea Amadori, Luca Ansaloni, Giuseppe Cariti, Franco De Cian, Pierandrea De Iaco, Michele De Simone, Marcello Deraco, Annibale Donini, Giammaria Fiorentini, Luigi Frigerio, Stefano Greggi, Antonio Macrì, Enrico Maria Pasqual, Franco Roviello, Paolo Sammartino, Cinzia Sassaroli, Giovanni Scambia, Carlo Staudacher, Patrizia Vici, Enrico Vizza, Mario Valle
Ovarian cancer (OC) remains relatively rare, although it is among the top 4 causes of cancer death for women younger than 50. The aggressive nature of the disease and its often late diagnosis with peritoneal involvement have an impact on prognosis. The current scientific literature presents ambiguous or uncertain indications for management of peritoneal carcinosis (PC) from OC, both owing to the lack of sufficient scientific data and their heterogeneity or lack of consistency. Therefore, the Italian Society of Surgical Oncology (SICO), the Italian Society of Obstetrics and Gynaecology, the Italian Association of Hospital Obstetricians and Gynaecologists, and the Italian Association of Medical Oncology conducted a multidisciplinary consensus conference (CC) on management of advanced OC presenting with PC during the SICO annual meeting in Naples, Italy, on September 10-11, 2015...
April 20, 2017: Tumori
https://www.readbyqxmd.com/read/28419679/assessing-the-survival-impact-of-perioperative-opioid-consumption-in-children-and-adolescents-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#2
Pascal Owusu-Agyemang, Andrea Hayes-Jordan, Antoinette Van Meter, Uduak U Williams, Acsa M Zavala, Ravish Kapoor, Shannon M Popovich, Elizabeth Rebello, Lei Feng, Juan P Cata
BACKGROUND: Several studies in adult patients have suggested an unfavorable association between opioid consumption and cancer progression. AIMS: This study investigated the impact of opioid consumption on the survival of children and adolescents undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. METHODS: A retrospective study of patients <19 years who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy was performed...
April 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28415645/peritoneal-carcinomatosis-limits-of-diagnosis-and-the-case-for-liquid-biopsy
#3
REVIEW
James R W McMullen, Matthew Selleck, Nathan R Wall, Maheswari Senthil
Peritoneal Carcinomatosis (PC) is a late stage manifestation of several gastrointestinal malignancies including appendiceal, colorectal, and gastric cancer. In PC, tumors metastasize to and deposit on the peritoneal surface and often leave patients with only palliative treatment options. For colorectal PC, median survival is approximately five months, and palliative systemic therapy is able to extend this to approximately 12 months. However, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) with a curative intent is possible in some patients with limited tumor burden...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413381/delayed-cytoreductive-nephrectomy-following-three-years-of-targeted-therapy-for-metastatic-renal-cell-carcinoma
#4
Ariel Schulman, Mathew Fakhoury, Jean P Wuilleumier, Kevin Becker, Bernadine Donahue, Ruoqing Huang, James Butler, Howard Goodman, Ervin Teper, David Silver
We present a 55-year-old male, with good performance status who was diagnosed with a case of metastatic renal cell carcinoma following a pathologic femur fracture. Despite good performance status, multifocal metastases and poor-prognostic features portended a grim prognosis with predicted overall survival of less than nine months. On initial presentation, he was excluded from cytoreductive nephrectomy based on brain metastasis and interleukin-2 was not pursued as the primary tumor was to be left in situ. The patient was reconsidered for cytoreductive nephrectomy after sustained response to fifth line targeted therapies with shrinkage of tumor burden...
January 2017: Current Urology
https://www.readbyqxmd.com/read/28411306/is-fecal-diversion-needed-in-pelvic-anastomoses-during-hyperthermic-intraperitoneal-chemotherapy-hipec
#5
Matthew D Whealon, John V Gahagan, Sarath Sujatha-Baskar, Michael P O'Leary, Matthew Selleck, Sinziana Dumitra, Byrne Lee, Maheswari Senthil, Alessio Pigazzi
BACKGROUND: The role of fecal diversion with pelvic anastomosis during cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is not well defined. METHODS: A retrospective review of patients who underwent CRS and HIPEC between 2009 and 2016 was performed to identify those with a pelvic anastomosis (colorectal, ileorectal, or coloanal anastomosis). RESULTS: The study identified 73 patients who underwent CRS and HIPEC at three different institutions between July 2009 and June of 2016...
April 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28409831/postoperative-complications-affect-long-term-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-peritoneal-carcinomatosis
#6
Lawrence Lee, Fanny Alie-Cusson, Pierre Dubé, Lucas Sideris
BACKGROUND AND OBJECTIVES: Morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for colorectal peritoneal carcinomatosis (PC) may negatively affect survival. The objective was to determine the impact of postoperative complications (CX) on survival in patients undergoing CRS + HIPEC for colorectal PC. METHODS: All patients undergoing laparotomy for planned CRS + HIPEC for colorectal PC at a single institution from 1999 to 2014 were included...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28406930/eutopic-ectopic-endometrial-apoptosis-initiated-by-bilateral-uterine-artery-occlusion-a-new-therapeutic-mechanism-for-uterus-sparing-surgery-in-adenomyosis
#7
Li Chen, Caixia Li, Jing Guo, Ning Luo, Xiaoyan Qu, Le Kang, Mingmin Liu, Zhongping Cheng
The objective of the present study was to investigate differences in the expression of apoptosis-related factors in the eutopic and ectopic endometrium (EuE/EE) in women with adenomyosis before and after laparoscopic bilateral uterine artery occlusion (LUAO). Ten patients with uterine adenomyosis who received LUAO were selected as the research subjects, from whom EuE and EE tissues were obtained before and after LUAO and detected for the expression of apoptosis-related molecules in EuE and EE by PT-PCR and Western blot, and changes in the mitochondrial structure by electron microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28406844/the-role-of-he4-a-novel-biomarker-in-predicting-optimal-cytoreduction-after-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#8
Francesco Plotti, Giuseppe Scaletta, Stella Capriglione, Roberto Montera, Daniela Luvero, Salvatore Lopez, Alessandra Gatti, Carlo De Cicco Nardone, Corrado Terranova, Roberto Angioli
OBJECTIVES: This study aimed to evaluate serum human epididymis protein 4 (HE4) changes during neoadjuvant chemotherapy (NACT) to establish HE4 predebulking surgery cutoff values and to demonstrate that CA125, HE4, and computed tomography (CT) taken together are better able to predict complete cytoreduction after NACT in advanced ovarian cancer patients. METHODS: From January 2006 to November 2015, patients affected by epithelial advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage III-IV), considered not optimally resectable, were included in this prospective study...
April 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28404198/molecular-fluorescence-guided-surgery-of-peritoneal-carcinomatosis-of-colorectal-origin-a-single-centre-feasibility-study
#9
Niels J Harlaar, Marjory Koller, Steven J de Jongh, Barbara L van Leeuwen, Patrick H Hemmer, Schelto Kruijff, Robert J van Ginkel, Lukas B Been, Johannes S de Jong, Gursah Kats-Ugurlu, Matthijs D Linssen, Annelies Jorritsma-Smit, Marleen van Oosten, Wouter B Nagengast, Vasilis Ntziachristos, Gooitzen M van Dam
BACKGROUND: Optimum cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is essential for the curative treatment of peritoneal carcinomatosis of colorectal origin. At present, surgeons depend on visual inspection and palpation for tumour detection. Improved detection of tumour tissue using molecular fluorescence-guided surgery could not only help attain a complete cytoreduction of metastatic lesions, but might also prevent overtreatment by avoiding resection of benign lesions...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28400138/influence-of-simultaneous-liver-and-peritoneal-resection-on-postoperative-morbi-mortality-and-survival-in-patients-with-colon-cancer-treated-with-surgical-cytoreduction-and-intraperitoneal-hyperthermic-chemotherapy
#10
Rafael Morales Soriano, José Miguel Morón Canis, Xavier Molina Romero, Judit Pérez Celada, Silvia Tejada Gavela, Juan José Segura Sampedro, Patricia Jiménez Morillas, Paula Díaz Jover, José María García Pérez, Fátima Sena Ruiz, Xavier González Argente
INTRODUCTION: Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy (HIPEC) has recently been established as the treatment of choice for selected patients with peritoneal carcinomatosis of colonic origin. Until recently, the simultaneous presence of peritoneal and hepatic dissemination has been considered a contraindication for surgery. The aim of this paper is to analyze the morbidity, mortality and survival of patients with simultaneous peritoneal and hepatic resection with HIPEC for peritoneal carcinomatosis secondary to colon cancer...
April 9, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28399919/long-term-survival-of-high-grade-primary-peritoneal-papillary-serous-adenocarcinoma-a-case-report-and-literature-review
#11
Jingping Yuan, Liang He, Bing Han, Yan Li
BACKGROUND: Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon disease which has a high malignancy and a poor prognosis. CASE PRESENTATION: We report here a long-term survival case of PPPSC with postoperative lung metastasis. A 62-year-old female patient with PPPSC was administered two cycles of neoadjuvant chemotherapy (NAC) followed by cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and six cycles of platinum-based (docetaxel + carboplatin) intraperitoneal chemotherapy postoperatively...
April 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28393331/role-of-crs-and-hipec-in-appendiceal-and-colorectal-malignancies-indian-experience
#12
Nikhil Gupta, Syed Asif, Jatin Gandhi, Sajjan Rajpurohit, Shivendra Singh
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are recently being considered as standard of treatment for patients with peritoneal carcinomatosis of appendiceal or colorectal origin. It is an extensive procedure with high morbidity. Being a newer treatment modality, not much experience has been published from an Indian center about it. METHODS: All patients of colorectal and appendiceal cancer with peritoneal metastasis from January 2012 to March 2015 who were planned for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) were analyzed with respect to morbidity, mortality, and survival...
April 10, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28389144/clear-cell-carcinomas-of-the-ovary-have-poorer-outcomes-compared-with-serous-carcinomas-results-from-a-single-center-taiwanese-study
#13
Fei-Chun Ku, Ren-Chin Wu, Lan-Yan Yang, Yun-Hsin Tang, Wei-Yang Chang, Jung-Erh Yang, Chun-Chieh Wang, Shih-Ming Jung, Cheng-Tao Lin, Ting-Chang Chang, Angel Chao, Chyong-Huey Lai
BACKGROUND/PURPOSE: To compare the clinical outcomes of Taiwanese patients with ovarian clear cell carcinomas (CCCs) and serous carcinomas (SCs). METHODS: We retrieved the clinical records of women with epithelial ovarian cancer (Stage I-IV) who received primary surgeries between 2000 and 2013. Cancer-specific survival (CSS), progression-free survival, and survival after recurrence (SAR) of CCC and SC patients were retrospectively compared. Multivariate analysis was used to identify the independent predictors of survival...
April 4, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28383447/timing-of-systemic-chemotherapy-in-patients-with-colorectal-peritoneal-carcinomatosis-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Wijntje J van Eden, Niels F Kok, Katarzyna Jóźwiak, Max L Lahaye, Geerard L Beets, Monique E van Leerdam, Henk Boot, Arend G Aalbers
BACKGROUND: Timing of systemic chemotherapy in patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is controversial. Preoperative systemic chemotherapy may offer benefits. OBJECTIVE: The purpose of this study was to evaluate the effect of timing of systemic chemotherapy on survival. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a tertiary referral center...
May 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28373757/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-treatment-of-gastric-cancer-with-peritoneal-carcinomatosis
#15
Lynne M Ellison, Yangao Man, Alexander Stojadinovic, Hongwu Xin, Itzhak Avital
Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28373041/-intraperitoneal-photodynamic-therapy-for-peritoneal-metastasis-of-epithelial-ovarian-cancer-limits-and-future-prospects
#16
H Azaïs, S Mordon, P Collinet
High peritoneal recurrence rate in advanced epithelial ovarian cancer after complete macroscopic cytoreductive surgery and platinum-based chemotherapy, raises the issue of peritoneal microscopic disease management and requires the development of additional locoregional treatment strategies. Photodynamic therapy is an effective treatment already applied in other medical and surgical indications. After administration of a photosensitizer which accumulates in cancer cells, illumination with a light of adequate wavelength may induce photochemical reaction between photosensitizer and tissue oxygen which lead to reactive oxygen species production and cytotoxic phenomenon...
March 31, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28368547/the-survival-advantage-of-supratotal-resection-of-glioblastoma-using-selective-cortical-mapping-and-the-subpial-technique
#17
Yoshua Esquenazi, Elliott Friedman, Zheyu Liu, Jay-Jiguang Zhu, Sigmund Hsu, Nitin Tandon
BACKGROUND: A substantial body of evidence suggests that cytoreductive surgery is a prerequisite to prolonging survival in patients with glioblastoma (GBM). OBJECTIVE: To evaluate the safety and impact of "supratotal" resections beyond the zone of enhancement seen on magnetic resonance imaging scans, using a subpial technique. METHODS: We retrospectively evaluated 86 consecutive patients with primary GBM, managed by the senior author, using a subpial resection technique with or without carmustine (BCNU) wafer implantation...
March 23, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28366546/trends-and-factors-associated-with-radical-cytoreductive-surgery-in-the-united-states-a-case-for-centralized-care
#18
A K Sinno, X Li, R E Thompson, E J Tanner, K L Levinson, R L Stone, S M Temkin, A N Fader, D S Chi, K Long Roche
OBJECTIVES: To describe the US national trends and factors associated with cytoreductive surgical radicality in women with advanced ovarian cancer (OC). METHODS: An analysis of the National Inpatient Sample database was performed. All admissions from 1993 to 2011 for advanced OC cytoreductive surgery (CRS) were identified and categorized as simple pelvic (SP), extensive pelvic (EP), and extensive upper abdominal (EUA) surgery. Annual trends in CRS were analyzed...
March 30, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28365962/outcomes-of-cytoreductive-surgery-and-hipec-for-pseudomyxoma-peritonei-of-appendiceal-origin-from-two-indian-centers-a-preliminary-five-year-experience
#19
Aditi Bhatt, Deepak Sheshadri, Garud Chandan, Veena Ramaswamy, Jeegeshwar Pandey, Nitin Bhorkar, Deepesh Agrawal, Sanket Mehta
PURPOSE: To evaluate the short-term outcomes of patients of pseudomyxoma peritonei (PMP) of appendiceal origin treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at two tertiary Indian centers. METHODS: Data was prospectively collected from January 2011 to January 2016. Palliative procedures were excluded. HIPEC was performed by the coliseum technique using either a mitomycin or oxaliplatin-based regimen. RESULTS: 77 procedures were performed on 71 patients...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28365932/usefulness-of-human-epididymis-protein-4-in-predicting-optimal-cytoreductive-therapy-in-patients-with-advanced-ovarian-cancer
#20
Vesna Paunovic, Zoran Protrka, Daniela Ardalic, Tomislav Paunovic
PURPOSE: Human Epididymis Protein 4 (HE4) is a novel promising serum biomarker of high sensitivity and specificity for ovarian cancer (OC). We investigated the usefulness of HE4 in predicting the outcome of surgery of advanced OC. METHODS: Fifty patients with OC (FIGO stage III and IV) entered the study. Serum concentrations of HE4 and CA125 were evaluated preoperatively. All patients had been operated between January 2014 - January 2016. RESULTS: Preoperatively, the mean concentration of HE4 was 628pmol/L...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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