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https://www.readbyqxmd.com/read/28811831/potent-phosphodiesterase-inhibition-and-nitric-oxide-release-stimulation-of-anti-impotence-thai-medicinal-plants-from-manosroi-iii-database
#1
Aranya Manosroi, Theeraphong Tangjai, Charinya Chankhampan, Worapaka Manosroi, Yaravee Najarut, Worapong Kitdamrongtham, Jiradej Manosroi
Seven plants in the top rank were selected from the "MANOSROI III" database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildenafil, a standard anti-impotence drug. Plumbago indica Linn. extract [EDP2-001(1)] exhibited the highest NO release stimulation activity of 666.85% which was 1.50-fold acetylcholine, a standard drug. Most selected plant extracts were nontoxic to EA.hy926 cells at 1...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28810937/tweets-gangs-and-guns-a-snapshot-of-gang-communications-in-detroit
#2
Desmond Patton, Sadiq Patel, Jun Sung Hong, Megan Ranney, Marie Crandall, Lyle Dungy
The aim of this study is to determine the frequency of violent and criminal Twitter communications among gang-affiliated individuals in Detroit, Michigan. We analyzed 8.5 million Detroit gang members' tweets from January 2013 to March 2014 to assess whether they contained Internet banging-related keywords. We found that 4.7% of gangaffiliated user tweets consisted of terms related to violence and crime. Violence and crime-related communications fell into 4 main categories: (a) beefing (267,221 tweets), (b) grief (79,971 tweets), (c) guns (3,551 tweets), and (d) substance use and distribution (47,638 tweets)...
August 15, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28809453/a-meta-analysis-micrornas-prognostic-function-in-patients-with-nonsmall-cell-lung-cancer
#3
REVIEW
Na Yu, Qingjun Zhang, Qing Liu, Jiayu Yang, Sheng Zhang
Accumulating papers have demonstrated that microRNAs play an important role in the progression of lung cancer, mainly as oncogenic and tumor suppressive. Therefore, microRNAs may influence the survival of lung cancer patients. In this meta-analysis, we evaluated the role of microRNAs in affecting the overall survival in nonsmall cell lung cancer (NSCLC) patients, which may provide valuable information for the treatment of nonsmall cell lung cancer. We used keywords to retrieve literatures from online databases PUBMED, EMBASE and Web of Science and included 12 studies into our investigation according to pre-set criteria...
August 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28809371/the-role-of-micrornas-in-oral-lichenoid-disorders-systematic-review
#4
A Setién-Olarra, M-L Gainza-Cirauqui, J-M Aguirre-Urizar, X Marichalar-Mendia
BACKGROUND: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD). MATERIAL AND METHODS: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28808876/changes-of-cerebrospinal-fluid-a%C3%AE-42-t-tau-and-p-tau-in-parkinson-s-disease-patients-with-cognitive-impairment-relative-to-those-with-normal-cognition-a-meta-analysis
#5
Xiaohui Hu, Yan Yang, Daokai Gong
The cerebrospinal fluid (CSF) signature of reduced amyloid beta 1-42 (Aβ42), elevated total tau (t-tau), and phosphorylated tau181 (p-tau) is important for the early diagnosis of Alzheimer's disease (AD). Aβ42, t-tau, and p-tau have been reported in numerous studies to contribute to predicting cognitive impairment in Parkinson's disease (PDCI). However, no consistent conclusion can be drawn so far. Literatures regarding Aβ42, t-tau, and p-tau in CSF were systematically reviewed, and a meta-analysis was thus performed to evaluate the changes of these biomarkers in PDCI patients, including PD with mild cognitive impairment (PDMCI) and PD dementia (PDD) patients, relative to PD with normal cognition (PDNC) patients...
August 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28808792/using-natural-language-processing-of-free-text-radiology-reports-to-identify-type-1-modic-endplate-changes
#6
Hannu T Huhdanpaa, W Katherine Tan, Sean D Rundell, Pradeep Suri, Falgun H Chokshi, Bryan A Comstock, Patrick J Heagerty, Kathryn T James, Andrew L Avins, Srdjan S Nedeljkovic, David R Nerenz, David F Kallmes, Patrick H Luetmer, Karen J Sherman, Nancy L Organ, Brent Griffith, Curtis P Langlotz, David Carrell, Saeed Hassanpour, Jeffrey G Jarvik
Electronic medical record (EMR) systems provide easy access to radiology reports and offer great potential to support quality improvement efforts and clinical research. Harnessing the full potential of the EMR requires scalable approaches such as natural language processing (NLP) to convert text into variables used for evaluation or analysis. Our goal was to determine the feasibility of using NLP to identify patients with Type 1 Modic endplate changes using clinical reports of magnetic resonance (MR) imaging examinations of the spine...
August 14, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28808632/survival-rates-against-fracture-of-endodontically-treated-posterior-teeth-restored-with-full-coverage-crowns-or-resin-composite-restorations-a-systematic-review
#7
REVIEW
Warattama Suksaphar, Danuchit Banomyong, Titalee Jirathanyanatt, Yaowaluk Ngoenwiwatkul
This systematic review aims to summarize the current clinical studies that investigated survival rates against fracture of endodontically treated posterior teeth restored with crowns or resin composite restorations. Literature search were performed using keywords. Publications from 1980 to 2016 were searched in PubMed, ScienceDirect, Web of Science, MEDLINE, and SCOPUS. Included studies were selected based on inclusion and exclusion criteria. Three clinical studies were included: 1 randomized controlled trial and 1 prospective and 1 retrospective cohort studies...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28808629/return-to-sport-following-tibial-plateau-fractures-a-systematic-review
#8
Greg A J Robertson, Seng J Wong, Alexander M Wood
AIM: To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods. METHODS: A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords "tibial", "plateau", "fractures", "knee", "athletes", "sports", "non-operative", "conservative", "operative", "return to sport"...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28808609/optimizing-peripheral-blood-stem-cells-transplantation-outcome-through-amend-relapse-and-graft-failure-a-review-of-current-literature
#9
REVIEW
Saeed Mohammadi, Amir Hossein Norooznezhad, Ashraf Malek Mohammadi, Hajar Nasiri, Mohsen Nikbakht, Najmaldin Saki, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been considered as a valuable approach in treatment of numerous malignant and none malignant hematologic disorders. However, relapse and poor graft function (PGF) after allo-SCT remain to be controversial issues which may affect the transplantation outcome. Relevant articles were searched in MEDLINE database (2000-2016) using keywords and phrases: donor lymphocyte infusions, allogeneic stem cells transplantation, relapsed hematologic malignancies, booster schedules, cell dose, laboratory monitoring protocols and technical aspects of apheresis...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28808449/efficacy-of-enamel-matrix-derivative-in-vital-pulp-therapy-a-review-of-literature
#10
REVIEW
Shariq Najeeb, Zohaib Khurshid, Muhammad Sohail Zafar, Sana Zohaib, Fahad Siddiqui
INTRODUCTION: Vital pulp therapy (VPT) aims to preserve the health and maintain life of the tooth pulp which has been compromised by caries, trauma or restorative procedures. Recently, enamel matrix derivative (EMD) has been introduced as a material for vital pulp therapy. The aim of this review is to critically analyze and summarize the available literature on EMD for VPT. METHODS AND MATERIALS: Online databases (PubMED/MEDLINE, Google Scholar, ISI Web of Science, and Wiley-Online) were searched by using the following keywords in various combinations: Enamel Matrix Derivative, Emdogain, 'Vital Pulp Therapy, 'Apexogenisis', Apexification, Pulp Capping, Endodontics, Dentine and Pulpotomy for studies indexed from January 1949 to April 2016...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28806822/-multiple-myeloma-current-status-in-diagnostic-testing-and-therapy
#11
Michael Kehrer, Sebastian Koob, Andreas Strauss, Dieter Christian Wirtz, Jan Schmolders
Background Multiple myeloma is a haematological blood cancer of the bone marrow and is classified by the World Health Organisation (WHO) as a plasma cell neoplasm. In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of an abnormal immunoglobulin called monoclonal protein or M protein. This ultimately causes multiple myeloma symptoms such as bone damage or kidney problems. The annual worldwide incidence of multiple myeloma is estimated to be 6 - 7/100,000 and accounts for 1% of all cancer...
August 14, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28806618/public-sentiment-and-discourse-about-zika-virus-on-instagram
#12
E K Seltzer, E Horst-Martz, M Lu, R M Merchant
OBJECTIVE: Social media have strongly influenced the awareness and perceptions of public health emergencies, and a considerable amount of social media content is now shared through images, rather than text alone. This content can impact preparedness and response due to the popularity and real-time nature of social media platforms. We sought to explore how the image-sharing platform Instagram is used for information dissemination and conversation during the current Zika outbreak. STUDY DESIGN: This was a retrospective review of publicly posted images about Zika on Instagram...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28804860/temperature-drop-and-the-risk-of-asthma-a-systematic-review-and-meta-analysis
#13
Xiaowei Cong, Xijin Xu, Yuling Zhang, Qihua Wang, Long Xu, Xia Huo
The relationship between asthma and temperature changes remains controversial. The aim of this study was to investigate the association between temperature changes and the risk of asthma. A total of 26 studies (combined total number of subjects N > 26 million), covering 13 countries and Costa Rica, were identified by using a series of keywords in different combinations and searching the papers in PubMed, EMBSEA, Web of Science, MEDLINE, AIM, LILACS, and WPRIM before February 2016. Most of the papers were published in English...
August 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28804704/hypoxia-in-cervical-cancer-from-biology-to-imaging
#14
REVIEW
Heidi Lyng, Eirik Malinen
PURPOSE: Hypoxia imaging may improve identification of cervical cancer patients at risk of treatment failure and be utilized in treatment planning and monitoring, but its clinical potential is far from fully realized. Here, we briefly describe the biology of hypoxia in cervix tumors of relevance for imaging, and evaluate positron emission tomography (PET) and magnetic resonance imaging (MRI) techniques that have shown promise for assessing hypoxia in a clinical setting. We further discuss emerging imaging approaches, and how imaging can play a role in future treatment strategies to target hypoxia...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28803679/systematic-review-of-the-methods-predictive-of-the-functionality-of-kidney-transplantation
#15
E Miret Alomar, E Trilla Herrera, D Lorente Garcia, L Regis Placido, R López Del Campo, M Cuadras Solé, T Pont Castellana, F Moreso Mateos, D Serón Micas, J Morote Robles
CONTEXT: Kidney transplantation from donors with expanded criteria has increased the pool of kidneys at the cost of a higher risk of short and long-term graft dysfunction. The main issue lies in determining which kidneys will offer acceptable function and survival compared with the risk represented by surgery and subsequent immunosuppression. OBJECTIVE: The objective of our article is to review the current evidence on the tools for predicting the functionality of kidney transplantation from cadaveric donors with expanded criteria and determining the validity for their use in standard practice...
August 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28801178/impact-of-head-and-neck-radiotherapy-on-the-mechanical-behavior-of-composite-resins-and-adhesive-systems-a-systematic-review
#16
REVIEW
Cristhian Camilo Madrid Troconis, Alan Roger Santos-Silva, Thaís Bianca Brandão, Marcio Ajudarte Lopes, Mario Fernando de Goes
OBJECTIVES: To analyze the evidence regarding the impact of head and neck radiotherapy (HNRT) on the mechanical behavior of composite resins and adhesive systems. METHODS: Searches were conducted on PubMed, Embase, Scopus and ISI Web of Science databases using "Radiotherapy", "Composite resins" and "Adhesive systems" as keywords. Selected studies were written in English and assessed the mechanical behavior of composite resins and/or adhesive systems when bonding procedure was conducted before and/or after a maximum radiation dose ≥50Gy, applied under in vitro or in vivo conditions...
August 8, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28800058/effectiveness-of-mifamurtide-in-addition-to-standard-chemotherapy-for-high-grade-osteosarcoma-a-systematic-review
#17
Rincy Jimmy, Cindy Stern, Karolina Lisy, Sarahlouise White
BACKGROUND: Osteosarcoma mostly occurs during the period of rapid bone growth in children and adolescents as high-grade osteosarcomas. Current treatment recommended for high-grade non-metastatic and metastatic and/or relapsed osteosarcoma involves neoadjuvant multiagent conventional chemotherapy, followed by surgical resection of macroscopically detected tumor and postoperative adjuvant chemotherapy. However, residual micrometastatic deposits that develop following surgery have shown resistance to postoperative/adjuvant chemotherapy...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28800057/experiences-of-gynecological-cancer-patients-receiving-care-from-specialist-nurses-a-qualitative-systematic-review
#18
Olivia Cook, Meredith McIntyre, Katrina Recoche, Susan Lee
BACKGROUND: The care needs of women with gynecological cancer are complex and change over the course of their cancer journey. Specialist nurses are well positioned to play a role in meeting the needs of women with gynecological cancer although their role and scope of practice have not been well defined. As patients are a key stakeholder, understanding their experience of care is an important step in better defining the role and scope of practice of specialist nurses in gynecological oncology in Australia and New Zealand...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28799854/proteomic-studies-in-the-discovery-of-cerebrospinal-fluid-biomarkers-for-amyotrophic-lateral-sclerosis
#19
Peggy Barschke, Patrick Oeckl, Petra Steinacker, Albert Ludolph, Markus Otto
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative motor neuron disease, which usually leads to death within a few years. The diagnosis is mainly based on clinical symptoms and there is a need for ALS-specific biomarkers to make an early and precise diagnosis, for development of disease-modifying drugs and to gain new insights into pathophysiology. Areas covered: In the present review, we summarize studies using mass spectrometric (MS) approaches to identify protein alterations in the cerebrospinal fluid (CSF) of ALS patients...
August 14, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28799496/anti-inflammatory-natural-prenylated-phenolic-compounds-potential-lead-substances
#20
Viliam Brezáni, Karel Šmejkal, Jan Hošek, Veronika Tomášová
BACKGROUND: Natural phenolics are secondary plant metabolites, which can be divided into several categories with the common structural feature of phenolic hydroxyl. The biological activity of phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of prenyl connection and modification affects their biological activity. OBJECTIVE: This review summarizes information about prenylated phenols and some of their potential sources, and provides an overview of their anti-inflammatory potential in vitro and in vivo...
August 10, 2017: Current Medicinal Chemistry
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