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First trimester ultrasound

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https://www.readbyqxmd.com/read/29439729/application-of-neural-networks-for-classification-of-patau-edwards-down-turner-and-klinefelter-syndrome-based-on-first-trimester-maternal-serum-screening-data-ultrasonographic-findings-and-patient-demographics
#1
Aida Catic, Lejla Gurbeta, Amina Kurtovic-Kozaric, Senad Mehmedbasic, Almir Badnjevic
BACKGROUND: The usage of Artificial Neural Networks (ANNs) for genome-enabled classifications and establishing genome-phenotype correlations have been investigated more extensively over the past few years. The reason for this is that ANNs are good approximates of complex functions, so classification can be performed without the need for explicitly defined input-output model. This engineering tool can be applied for optimization of existing methods for disease/syndrome classification. Cytogenetic and molecular analyses are the most frequent tests used in prenatal diagnostic for the early detection of Turner, Klinefelter, Patau, Edwards and Down syndrome...
February 13, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29436713/when-ultrasound-anomalies-are-present-an-estimation-of-the-frequency-of-chromosome-abnormalities-not-detected-by-cell-free-dna-aneuploidy-screens
#2
Rebecca M Reimers, Heather Mason-Suares, Sarah E Little, Bryann Bromley, Emily S Reiff, Lori J Dobson, Louise Wilkins-Haug
OBJECTIVES: This study characterizes cytogenetic abnormalities with ultrasound findings to refine counseling following negative cell-free DNA (cfDNA). METHODS: A retrospective cohort of pregnancies with chromosome abnormalities and ultrasound findings was examined to determine the residual risk following negative cfDNA. Cytogenetic data was categorized as cfDNA detectable for aneuploidies of chromosomes 13, 18, 21, X, or Y or non-cfDNA detectable for other chromosome abnormalities...
February 13, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29435580/association-of-prenatal-ultrasonography-and-autism-spectrum-disorder
#3
N Paul Rosman, Rachel Vassar, Gheorghe Doros, James DeRosa, Allison Froman, Audrey DiMauro, Sherry Santiago, Jodi Abbott
Importance: The prevalence of autism spectrum disorder (ASD) has been increasing rapidly, with current estimates of 1 in 68 children affected. Simultaneously, use of prenatal ultrasonography has increased substantially, with limited investigation into its safety and effects on brain development. Animal studies have demonstrated that prenatal ultrasonography can adversely affect neuronal migration. Objective: To quantify prenatal ultrasound exposure by the frequency, timing, duration, and strength of ultrasonographic scans in children with later ASD, developmental delay, and typical development...
February 12, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29435489/the-use-of-ultrasound-as-a-potential-adjunct-to-cell-free-fetal-dna-screening-for-aneuploidy-at-weill-cornell-medical-college-new-york-usa
#4
Jessica Scholl, Stephen Chasen
Objective  To evaluate the utility of ultrasound in identifying fetuses with uncommon chromosomal abnormalities that would be considered not detectable by cell-free fetal deoxyribonucleic acid (cfDNA). Study Design  We performed a retrospective study of fetuses with chromosomal abnormalities that would be undetectable by cfDNA, who underwent an 11- to 14-week ultrasound from 2006 to 2016. Results  There were 43 pregnancies included. First-trimester ultrasound revealed a fetal abnormality in 19 (44.2%) cases, of which 13 (30...
January 2018: Surgery Journal
https://www.readbyqxmd.com/read/29422212/diagnosis-and-surveillance-of-late-onset-fetal-growth-restriction
#5
REVIEW
Francesc Figueras, Javier Caradeux, Fatima Crispi, Elisenda Eixarch, Anna Peguero, Eduard Gratacos
By consensus, late fetal growth restriction is that diagnosed >32 weeks. This condition is mildly associated with a higher risk of perinatal hypoxic events and suboptimal neurodevelopment. Histologically, it is characterized by the presence of uteroplacental vascular lesions (especially infarcts), although the incidence of such lesions is lower than in preterm fetal growth restriction. Screening procedures for fetal growth restriction need to identify small babies and then differentiate between those who are healthy and those who are pathologically small...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29415594/maternal-obesity-is-not-associated-with-increased-crown-rump-length-in-first-trimester-ultrasounds-of-singleton-gestations
#6
Geoffrey H Gordon, Kathleen M Antony, Emmanuel Sampene, Jesus Igor Iruretagoyena
OBJECTIVE: To evaluate whether or not obesity affects fetal growth in the first trimester of pregnancy. STUDY DESIGN: A retrospective cohort study of obese versus nonobese women in our ultrasound database was performed to compare crown-rump length (CRL), a surrogate of fetal growth, at the first-trimester genetic screening. RESULTS: A total of 50 obese and 50 nonobese women were included. CRL for both groups was performed at an average of 12wk5d ± 3 d...
February 7, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29405964/new-insights-in-the-pathophysiology-of-complete-hydatidiform-mole
#7
Eric Jauniaux, Maria Memtsa, Jemma Johns, Jackie A Ross, Davor Jurkovic
OBJECTIVE: The majority of complete hydatidiform moles (CHM) are detected on ultrasound examination by the end of the first trimester when they present as multiple sonolucent cysts. To better understand the pathophysiology of this unique placental pathology and improve its prenatal diagnosis and management we have reviewed the ultrasound features of CHM before the appearance of cystic changes. STUDY DESIGN: We searched our database to identify all women diagnosed with a complete hydatidiform mole confirmed by histopathology who had an ultrasound examination before 9 weeks' gestation...
February 2018: Placenta
https://www.readbyqxmd.com/read/29396076/-what-are-the-real-purpose-and-scope-of-screening-for-aneuploidy
#8
T Quibel, P Rozenberg
In France, the recommended method for Down syndrome screening is the first trimester combined test, the risk assessment, based on maternal age, ultrasound measurement of fetal nuchal translucency and maternal serum markers (free β-hCG and PAPP-A). The Down syndrome detection rate is 78.7% at a screen positive rate of 5%. However, the best screening test is the integrated test using a combination of first trimester combined test and second trimester quadruple test (serum α-fetoprotein, human chorionic gonadotropin, unconjugated E3, and dimeric inhibin-A) and being able to achieve a detection rate for Down syndrome of approximately 96% at a screen-positive rate of 5%...
January 27, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29386348/first-trimester-fetal-size-and-prescribed-asthma-medication-at-15%C3%A2-years-of-age
#9
Steve Turner, Shona Fielding, Graham Devereux
There is increasing evidence that antenatal factors predispose to childhood asthma. We tested the hypothesis that reduced first trimester fetal size is associated with increased risk for asthma at 15 years of age.Fetal size in the first and second trimester was ascertained by ultrasound scan. The primary outcome of being dispensed one or more asthma medications by the family doctor in the year before the 15th birthday was determined from routinely acquired dispensing data.Dispensing data were available for 1699 (88% of the original cohort) participants at 15 years of age and questionnaire data for 750 (39%)...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29381790/adherence-to-a-healthy-eating-index-for-pregnant-women-is-associated-with-lower-neonatal-adiposity-in-a-multiethnic-asian-cohort-the-growing-up-in-singapore-towards-healthy-outcomes-gusto-study
#10
Ai-Ru Chia, Mya-Thway Tint, Chad Yixian Han, Ling-Wei Chen, Marjorelee Colega, Izzuddin M Aris, Mei-Chien Chua, Kok-Hian Tan, Fabian Yap, Lynette Pei-Chi Shek, Yap-Seng Chong, Keith M Godfrey, Marielle V Fortier, Yung Seng Lee, Mary Foong-Fong Chong
Background: Evidence linking maternal diet quality during pregnancy with infant birth outcomes is limited in Asia. Objective: We investigated the association of maternal diet quality with the risk of preterm birth, offspring birth size, and adiposity in a multiethnic Asian birth cohort. Design: Dietary intakes of 1051 pregnant women were ascertained at 26-28 wk of gestation with the use of 24-h recalls and 3-d food diaries, from which diet quality (score range: 0-100) was measured by the Healthy Eating Index for pregnant women in Singapore (HEI-SGP)...
January 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29380893/emergency-department-patient-perceptions-of-transvaginal-ultrasound-for-complications-of-first-trimester-pregnancy
#11
Nova Panebianco, Frances Shofer, Katie O'Conor, Tristan Wihbey, Lakeisha Mulugeta, Evan Suzuki, Adel Alghamdi, Anthony Dean
OBJECTIVES: Emergency department (ED) transvaginal ultrasound (US) is underused in clinical practice. This study assessed pregnant women's perceptions of ED transvaginal US in terms of pain, embarrassment, anxiety, and willingness to receive the procedure. Secondary variables include physicians' perceptions of patients' experiences. METHODS: Women undergoing US examinations for complications of first-trimester pregnancy were prospectively surveyed before any US and after ED and/or radiology transvaginal US...
January 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29380277/first-trimester-pregnancy-ultrasound-findings-as-a-function-of-method-of-conception-in-an-infertile-population
#12
Frauke von Versen-Höynck, Jenna S Petersen, Yueh-Yun Chi, Jing Liu, Valerie L Baker
PURPOSE: The aim of this study was to determine whether first trimester ultrasound measurements of crown rump length (CRL) and gestational sac diameter (GSD) differ depending on the method of conception among infertile women. METHOD: Infertile women, ages 21-50 years old, who conceived viable, singleton pregnancies via fresh embryo transfer (ET), frozen ET, non-in vitro fertilization (IVF) fertility treatment, or spontaneously were included in this observational cohort study at an academic fertility practice...
January 29, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29375147/letrozole-vs-placebo-pretreatment-in-the-medical-management-of-first-trimester-missed-miscarriage-a-randomized-controlled-trial
#13
Haitham A Torky, Heba Marie, ElSayed ElDesouky, Samy Gebreel, Osama Raslan, Asem A Moussa, Ali M Ahmad, Eman Zain, Mohamed N Mohsen
Introduction: Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim: The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed miscarriage. Design: This was a prospective randomized case-control study...
January 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29369818/early-fetal-megacystis-is-it-possible-to-predict-the-prognosis-in-the-first-trimester
#14
Ambra Iuculano, Cristina Peddes, Giovanni Monni
OBJECTIVE: To evaluate the best management of fetal megacystis diagnosed in the first trimester and define the prognosis and the most appropriate follow-up as early as possible. METHODS: This is a retrospective study of first-trimester fetal megacystis diagnosed in pregnant women who performed a combined screening for fetal aneuploidy. Megacystis was defined as a longitudinal bladder diameter (LBD) greater than 7 mm. All fetuses were divided into two groups according to the LBD: Group A with LBD > 15 mm and Group B with LBD < 15 mm...
January 24, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29352716/-echographic-diagnosis-of-missed-early-miscarriage-assessment-of-image-quality
#15
C Barthes, C Mezan De Malartic, C Baumann, H Rousseaux, O Morel
OBJECTIVE: Ultrasound examination plays a central role in case of suspected non-viable pregnancy. A wrong diagnosis might have major consequence in terms of inadequate care, especially in cases of false positive non-viable pregnancy diagnosis. Ultrasound criterions are today well defined. Our objective was to evaluate the feasibility and reproducibility of a novel image-quoting method of first-trimester non-viable pregnancy. METHODS: Thirty images of non-viable pregnancy were twice evaluated with blinded proofreading...
January 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29341510/maternity-ultrasound-in-the-republic-of-ireland-2016-a-review
#16
D Hayes-Ryan, K McNamara, N Russell, L Kenny, K O'Donoghue
Antenatal ultrasound, comprising of a dating ultrasound in the late first trimester followed by a fetal anomaly scan, is a recognised and necessary component of good antenatal care. We conducted a telephone survey of all 19 obstetric units to ascertain the status of maternity ultrasound provision in Ireland. Fetal anomaly ultrasound is offered universally to all women in 7/19 (37%) units, selectively to some women in 7/19 (37%) units and not offered at all in the remaining 5/19 (26%) units. Overall ? 41,700 (64%) women receive a fetal anomaly ultrasound nationally...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341210/subchorionic-hematoma-correlation-of-grading-techniques-with-first-trimester-pregnancy-outcome
#17
Howard T Heller, Elizabeth A Asch, Sara M Durfee, Robin P Goldenson, Hope E Peters, Elizabeth S Ginsburg, Peter M Doubilet, Carol B Benson
OBJECTIVES: To evaluate and compare grading systems of subchorionic hematoma (SCH) on first-trimester ultrasound examinations with live embryos to assess which best correlates with early pregnancy outcome and to assess the effect of gestational age at the time of diagnosis on outcome. METHODS: First-trimester live singleton pregnancies between 6 and 11 weeks' gestational age with SCH were identified by an institutional database search. First-trimester outcome was categorized as "live" or "demise" based on ultrasound or medical record documentation...
January 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29336851/clinical-utility-of-fetal-short-lag-spatial-coherence-imaging
#18
Will Long, Dongwoon Hyun, Kingshuk Roy Choudhury, David Bradway, Patricia McNally, Brita Boyd, Sarah Ellestad, Gregg E Trahey
In this study, we evaluate the clinical utility of fetal short-lag spatial coherence (SLSC) imaging. Previous work has documented significant improvements in image quality with fetal SLSC imaging as quantified by measurements of contrast and contrast-to-noise ratio (CNR). The objective of this study was to examine whether this improved technical efficacy is indicative of the clinical utility of SLSC imaging. Eighteen healthy volunteers in their first and second trimesters of pregnancy were scanned using a modified Siemens SC2000 clinical scanner...
January 11, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29319201/comparative-study-of-abdominal-versus-transvaginal-ultrasound-for-uterine-artery-doppler-velocimetry-at-11-to-13-weeks
#19
Marie-Elaine Demers, Samuel Dubé, Mélodie Bourdages, Cedric Gasse, Amélie Boutin, Mario Girard, Emmanuel Bujold, Suzanne Demers
OBJECTIVES: To compare the first-trimester uterine artery pulsatility index (PI) measured by abdominal and transvaginal ultrasound (US). METHODS: We performed a prospective study of singleton pregnant women recruited at 11 to 13 weeks' gestation. The mean uterine artery PI was obtained by abdominal followed by transvaginal US. The mean of the left and right uterine artery PIs was used, and differences between approaches were computed. The intraclass correlation coefficient and a Bland-Altman plot were used to compare the two approaches...
January 10, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29317419/cohort-profile-effect-of-malaria-in-early-pregnancy-on-fetal-growth-in-benin-recipal-preconceptional-cohort
#20
Manfred Accrombessi, Emmanuel Yovo, Gilles Cottrell, Gino Agbota, Agnès Gartner, Yves Martin-Prevel, Nadia Fanou-Fogny, Diane Djossinou, Jennifer Zeitlin, Nicaise Tuikue-Ndam, Florence Bodeau-Livinec, Sandrine Houzé, Nicola Jackson, Paul Ayemonna, Achille Massougbodji, Michel Cot, Nadine Fievet, Valérie Briand
PURPOSE: REtard de Croissance Intra-uterin et PALudisme (RECIPAL) is an original preconceptional cohort designed to assess the consequences of malaria during the first trimester of pregnancy, which is a poorly investigated period in Africa and during which malaria may be detrimental to the fetus. PARTICIPANTS: For this purpose, a total of 1214 women of reproductive age living in Sô-Ava and Akassato districts (south Benin) were followed up monthly from June 2014 to December 2016 until 411 of them became pregnant...
January 8, 2018: BMJ Open
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